o aminoazotoluene

Summary

Summary: An azo dye with carcinogenic properties.

Top Publications

  1. Jacobs J, Sinclair P, Bement W, Lambrecht R, Sinclair J, Goldstein J. Oxidation of uroporphyrinogen by methylcholanthrene-induced cytochrome P-450. Essential role of cytochrome P-450d. Biochem J. 1989;258:247-53 pubmed
    ..These data indicate that hepatic P-450d catalyses uroporphyrinogen oxidation. We suggest that the P-450d-catalysed oxidation of uroporphyrinogen has a role in the uroporphyria caused by hexachlorobenzene and other compounds...
  2. Smith D, Barker I, Allen O. The effect of certain topical medications on healing of cutaneous wounds in the common garter snake (Thamnophis sirtalis). Can J Vet Res. 1988;52:129-33 pubmed
    ..Wounds treated with an antibacterial spray powder and an antibacterial ointment healed more slowly than controls and had scores of -6 and -12 respectively...
  3. Timofeeva O, Eremeev A, Goloshchapov A, Kalashnikova E, Ilnitskaya S, Setkov N, et al. Effects of o-aminoazotoluene on liver regeneration and p53 activation in mice susceptible and resistant to hepatocarcinogenesis. Toxicology. 2008;254:91-6 pubmed publisher
    ..These results may have relevance to clinical observations of HCCs and implications for HCC chemoprevention and treatment...
  4. Eremeev A, Timofeeva O, Kaledin V, Setkov N. [Different sensitivity of inbred mice to hepatocarcinogen ortho-aminoazotoluene may be due to differences in the negative control mechanisms of hepatocyte proliferation]. Tsitologiia. 2004;46:301-11 pubmed
    ..These results enable us to conclude that OAT administrations break negative endogenous mechanisms of hepatocyte proliferation control in the liver of mice sensitive to carcinogenes...
  5. Algermissen B, Bauer F, Schadendorf D, Kropp J, Czarnetzki B. Analysis of mast cell subpopulations (MCT, MCTC) in cutaneous inflammation using novel enzyme-histochemical staining techniques. Exp Dermatol. 1994;3:290-7 pubmed
    ..These data suggest that disease-dependent mast cell dynamics involve only MCT in cutaneous inflammation and that MCT numbers are controlled by distinct, disease-specific local tissue factors...
  6. Popova N. Transgenerational effect of orthoaminoasotoluol in mice. Cancer Lett. 1989;46:203-6 pubmed
    ..The liver tumor incidence in males of the F2 (20.6%) and F3 (17.8%) generations was lower than in the control group (40.5%). The liver tumor incidence in the controls was similar to that observed in F3 females (4.05%)...
  7. Timofeeva O, Filipenko M, Rychkova N, Gulyaeva L, Lyakhovich V. Expression of CYP1A in liver of A/Sn and CC57BR mice differing in sensitivity to hepatocarcinogenesis induced by o-aminoazotoluene. Biochemistry (Mosc). 2000;65:718-22 pubmed
    ..Interstrain variation in Cyp1a1 and Cyp1a2 activities was also shown at the enzyme activity level. We suppose that quantitative differences in the Cyp1a2 mRNA level play a key role in OAT-induced hepatocarcinogenesis...
  8. Pakharukova M, Smetanina M, Kaledin V, Kobzev V, Romanova I, Merkulova T. Activation of constitutive androstane receptor under the effect of hepatocarcinogenic aminoazo dyes in mouse and rat liver. Bull Exp Biol Med. 2007;144:338-41 pubmed
    ..Ortho-aminoazotoluene and 3'-methyl-4-dimethylaminobenzene were better competitors for cytosol proteins from mouse and rat liver, respectively...
  9. Kropachev K, Kaledin V, Kobzev V, Plisov S, Levashova Z, Merkulova T. Involvement of transcription factor HNF3gamma in the effect of o-aminoazotoluene on glucocorticoid induction of tyrosine aminotransferase in mice sensitive to its hepatocarcinogenic action. Mol Carcinog. 2001;31:10-5 pubmed
    ..These results suggested that the inhibitory effect of OAT on the glucocorticoid induction of TAT is mediated by reduced HNF3gamma DNA-binding activity...

More Information

Publications23

  1. Lake B, Edwards A, Price R, Phillips B, Renwick A, Beamand J, et al. Lack of effect of furfural on unscheduled DNA synthesis in the in vivo rat and mouse hepatocyte DNA repair assays and in precision-cut human liver slices. Food Chem Toxicol. 2001;39:999-1011 pubmed
    ..Moreover, human liver slice studies suggest that furfural is also not a genotoxic agent in human liver...
  2. Zacharova L, Gulyaeva L, Lyakhovich V, Mikhailova O, Timofeeva O, Filipenko M, et al. Cytochrome P4501A1 and 1A2 gene expression in the liver of 3-methylcholanthrene- and o-aminoazotoluene-treated mice: a comparison between PAH-responsive and PAH-nonresponsive strains. Toxicol Sci. 2003;73:108-13 pubmed
    ..This comparison between aromatic hydrocarbon-responsive and -nonresponsive strains could contribute to understanding of cytochrome P4501A gene regulation in the liver under the influence of environmental factors...
  3. Il nitskaya S, Vasil Eva E, Kropachev K, Kaledin V. Relationship between high sensitivity of suckling mice to hepatocarcinogenic and antiglucocorticoid effects of o-aminoazotoluene and diethylnitrosamine. Bull Exp Biol Med. 2004;137:548-50 pubmed
    ..After treatment with o-aminoazotoluene and diethylnitrosamine HNF3-DNA-binding capacity and glucocorticoid-induced liver tyrosine aminotransferase activity in suckling mice decreased more significantly than in adult animals...
  4. Kropachev K, Pakharukova M, Bryzgalov L, Kaledin V, Kobzev V, Merkulova T. The unknown nuclear protein that decreases HNF3 activity ensures species specificity of action of hepatocarcinogenic amino azo dyes. Dokl Biochem Biophys. 2004;397:251-3 pubmed
  5. Baginskaya N, Il nitskaya S, Nikitenko E, Kaledin V. Promoting effect of o-aminoazotoluene on hepatocarcinogenesis is accompanied by the increase in inflammatory and proliferative processes in liver tissue and decrease in the concentration of free thyroxin in the blood. Bull Exp Biol Med. 2007;144:821-4 pubmed
    ..The concentration of free thyroxin decreased in the blood. Our results supplement published data that promoters of hepatocarcinogenesis inhibit thyroid function...
  6. Merkulova T, Kropachev K, Timofeeva O, Vasiliev G, Levashova Z, Ilnitskaya S, et al. Species-specific effects of the hepatocarcinogens 3'-methyl-4-dimethyl-aminoazobenzene and ortho-aminoazotoluene in mouse and rat liver. Mol Carcinog. 2005;44:223-32 pubmed
    ..32-0.47 g/mL interval of ammonium sulfate concentration. In contrast, non-specific hepatocarcinogen DENA was effective upon being added directly to Fraction I, implying a different mechanism of its action...
  7. Mikhailova O, Vasyunina E, Ovchinnikova L, Gulyaeva L, Timofeeva O, Filipenko M, et al. o-Aminoazotoluene does induce the enzymes of its own mutagenic activation in mouse liver. Toxicology. 2005;211:132-8 pubmed
    ..Thus, OAT does induce the enzymes of its own mutagenic activation in mouse liver...
  8. Mikhailova O, Filipenko M, Timofeeva O, Kaledin V, Guliaeva L, Liakhovich V. [mRNA level and cytochrome P450 1A activity in the liver of C57BL mice induced by various xenobiotics]. Biomed Khim. 2003;49:388-93 pubmed
    ..Thus, on the basis of the data obtained, the mRNA level can be considered as more accurate estimation of Cypla1 and Cypla2 inducibility, than the determination of the enzyme activity...
  9. Kohara A, Suzuki T, Honma M, Hirano N, Ohsawa K, Ohwada T, et al. Mutation spectrum of o-aminoazotoluene in the cII gene of lambda/lacZ transgenic mice (MutaMouse). Mutat Res. 2001;491:211-20 pubmed
    ..Sequence analysis revealed that AAT induced G:C to T:A transversions, whereas spontaneous mutations consisted primarily of G:C to A:T transitions at CpG sites...
  10. Ohsawa K, Hirano N, Sugiura M, Nakagawa S, Kimura M. Genotoxicity of o-aminoazotoluene (AAT) determined by the Ames test, the in vitro chromosomal aberration test, and the transgenic mouse gene mutation assay. Mutat Res. 2000;471:113-26 pubmed
  11. Hanigan M, Winkler M, Drinkwater N. Induction of three histochemically distinct populations of hepatic foci in C57BL/6J mice. Carcinogenesis. 1993;14:1035-40 pubmed
    ..Further studies of the molecular events giving rise to these distinct lesions will provide insights into the multiple pathways that result in hepatocarcinogenesis...
  12. Mishra A, Bajpai M. Flocculation behaviour of model textile wastewater treated with a food grade polysaccharide. J Hazard Mater. 2005;118:213-7 pubmed
    ..The experimental results show that the mucilage is more effective for removal of solubilised vat dye than for reactive black...
  13. Bryzgalov L, Ershov N, Oshchepkov D, Kaledin V, Merkulova T. Detection of target genes of FOXA transcription factors involved in proliferation control. Biochemistry (Mosc). 2008;73:70-5 pubmed
    ..The effect of hepatocarcinogen orthoaminoazotoluene (OAT), which lowers the FOXA activity, on expression of these genes was studied by the real-time PCR. OAT was shown to increase sharply the level of mRNA of the Cul2 and Cdc73 genes...
  14. Bryzgalov L, Ershov N, Ilnitskaya S. FOXA transcription factors determine the amplitude of glucocorticoid induction of tyrosine aminotransferase in mice. Bull Exp Biol Med. 2007;144:722-4 pubmed
    ..Our results suggest that FOXA proteins determine glucocorticoid induction of tyrosine aminotransferase in mice (similarly to rats)...