evans blue

Summary

Summary: An azo dye used in blood volume and cardiac output measurement by the dye dilution method. It is very soluble, strongly bound to plasma albumin, and disappears very slowly.

Top Publications

  1. Kozler P, Pokorny J. Altered blood-brain barrier permeability and its effect on the distribution of Evans blue and sodium fluorescein in the rat brain applied by intracarotid injection. Physiol Res. 2003;52:607-14 pubmed
    The aim was to study the blood-brain permeability according to the distribution in the rat brain of Evans blue (EB) and sodium fluorescein (NaFl) administered by an intracarotid injection...
  2. Rogers D, Boschetto P, Barnes P. Plasma exudation. Correlation between Evans blue dye and radiolabeled albumin in guinea pig airways in vivo. J Pharmacol Methods. 1989;21:309-15 pubmed
    We quantified the tissue exudation and luminal transudation of two plasma markers, Evans blue (EB) dye and [125I]-human serum albumin (HSA), into the airways of the anesthetized guinea pig in response to platelet activating factor (PAF)...
  3. Schumacher J, Binkowski K, Dendorfer A, Klotz K. Organ-specific extravasation of albumin-bound Evans blue during nonresuscitated hemorrhagic shock in rats. Shock. 2003;20:565-8 pubmed
    ..After 30 min of shock 50 mg/kg b.w. Evans blue (EB) was injected intravenously followed by an incubation period of 20 min...
  4. Sharma R, Otsuka M, Pande V, Inoue J, João Ramos M. Evans Blue is an inhibitor of nuclear factor-kappa B (NF-kappaB)-DNA binding. Bioorg Med Chem Lett. 2004;14:6123-7 pubmed
    ..In this context, we report Evans Blue as a novel inhibitor of NF-kappaB-DNA binding...
  5. Liu D, Ander B, Xu H, Shen Y, Kaur P, Deng W, et al. Blood-brain barrier breakdown and repair by Src after thrombin-induced injury. Ann Neurol. 2010;67:526-33 pubmed publisher
    ..Thrombin mediates the life-threatening cerebral edema that occurs after intracerebral hemorrhage. Therefore, we examined the mechanisms of thrombin-induced injury to the blood-brain barrier (BBB) and subsequent mechanisms of BBB repair...
  6. Yang F, Horng S, Lin Y, Kao Y. Association between contrast-enhanced MR images and blood-brain barrier disruption following transcranial focused ultrasound. J Magn Reson Imaging. 2010;32:593-9 pubmed publisher
    ..To investigate the correlation between the contrast-enhanced magnetic resonance imaging (MRI) signal and the duration of blood-brain barrier (BBB) disruption induced by focused ultrasound (FUS)...
  7. Chen K, Kuo E, Poon K, Cheng K, Chang C, Liu Y, et al. Increase in Evans blue dye extravasation into the brain in the late developmental stage. Neuroreport. 2012;23:699-701 pubmed publisher
    The development of the blood-brain barrier (BBB) against permeability to inert tracers, such as Evans blue dye (EBD), occurs quite early on at embryonic stages (before E13-E15), and the BBB remains resistant to EBD between E15 and early ..
  8. Carmichael N, Dostrovsky J, Charlton M. Enhanced vascular permeability in rat skin induced by sensory nerve stimulation: evaluation of the time course and appropriate stimulation parameters. Neuroscience. 2008;153:832-41 pubmed publisher
    ..measured the time course and extent of PE by digital imaging of changes in skin reflectance caused by leakage of Evans Blue (EB) dye infused in the circulatory system before stimulation...
  9. Ay I, Francis J, Brown R. VEGF increases blood-brain barrier permeability to Evans blue dye and tetanus toxin fragment C but not adeno-associated virus in ALS mice. Brain Res. 2008;1234:198-205 pubmed publisher
    ..We examined the effect of VEGF on the CNS distribution of three different agents: a small molecule (Evans blue dye) that is known to bind plasma proteins, an exogenous protein (tetanus toxin fragment C; TTC), and a viral ..

More Information

Publications76

  1. Zhang X, Xie Y, Jin Y, Hou X, Ye L, Lou J. The effect of RMP-7 and its derivative on transporting Evans blue liposomes into the brain. Drug Deliv. 2004;11:301-9 pubmed
    ..quot; Horse radish peroxide (HRP), liposome (HRP-L-PEG), and Evans blue (EB) liposome (EB-L-PEG) were prepared using the reverse-phase evaporation method...
  2. Kaya M, Ahishali B. Assessment of permeability in barrier type of endothelium in brain using tracers: Evans blue, sodium fluorescein, and horseradish peroxidase. Methods Mol Biol. 2011;763:369-82 pubmed publisher
    ..chapter, we aimed to highlight the basic knowledge on the use of three most commonly performed tracers, namely Evans blue dye, sodium fluorescein, and horseradish peroxidase...
  3. Manaenko A, CHEN H, Kammer J, Zhang J, Tang J. Comparison Evans Blue injection routes: Intravenous versus intraperitoneal, for measurement of blood-brain barrier in a mice hemorrhage model. J Neurosci Methods. 2011;195:206-10 pubmed publisher
    ..The Evans Blue assay is a popular method for the quantification of BBB disruption...
  4. Yang F, Lin Y, Kang K, Chao T. Reversible blood-brain barrier disruption by repeated transcranial focused ultrasound allows enhanced extravasation. J Control Release. 2011;150:111-6 pubmed publisher
    ..In this study, we demonstrate that, using this noninvasive treatment, Evans Blue (EB) extravasation can be enhanced by repeated sonication...
  5. Yen L, Wei V, Kuo E, Lai T. Distinct patterns of cerebral extravasation by Evans blue and sodium fluorescein in rats. PLoS ONE. 2013;8:e68595 pubmed publisher
    The Evans blue dye (EBD; 961 Da) and the sodium fluorescein dye (NaF; 376 Da) are commonly used inert tracers in blood-brain barrier (BBB) research...
  6. Tsopelas C, Bellon M, Bevington E, Kollias J, Shibli S, Chatterton B. Lymphatic mapping with 99mTc-Evans Blue dye in sheep. Ann Nucl Med. 2008;22:777-85 pubmed publisher
    99mTc-Evans Blue (EB) is an agent that contains both radioactive and color signals in a single dose...
  7. Winklmaier U, Wust K, Plinkert P, Wallner F. The accuracy of the modified Evans blue dye test in detecting aspiration in head and neck cancer patients. Eur Arch Otorhinolaryngol. 2007;264:1059-64 pubmed
    The purpose of this study was to determine sensitivity and specificity of the modified Evans blue dye test (MEBDT) in tracheostomised patients after treatment of head and neck squamous cell carcinoma (HNSCC)...
  8. Moitra J, Sammani S, Garcia J. Re-evaluation of Evans Blue dye as a marker of albumin clearance in murine models of acute lung injury. Transl Res. 2007;150:253-65 pubmed
    Quantifying the amount of albumin conjugated to Evans Blue dye (EBA) fluxing across organ-specific vascular barriers is a popular technique to measure endothelial monolayer integrity in rodent and murine models of human diseases...
  9. Alves da Silva J, Oliveira K, Camillo M. Gyroxin increases blood-brain barrier permeability to Evans blue dye in mice. Toxicon. 2011;57:162-7 pubmed publisher
    ..Mice treated with gyroxin showed an increase in the concentration of albumin-Evans blue in brain extracts, indicating an increase in the blood-brain barrier (BBB) permeability...
  10. Yao J, Maslov K, Hu S, Wang L. Evans blue dye-enhanced capillary-resolution photoacoustic microscopy in vivo. J Biomed Opt. 2009;14:054049 pubmed publisher
    ..To overcome this problem, we use Evans blue (EB) dye as a contrast agent for in vivo photoacoustic imaging...
  11. Bekeredjian R, Kroll R, Fein E, Tinkov S, Coester C, Winter G, et al. Ultrasound targeted microbubble destruction increases capillary permeability in hepatomas. Ultrasound Med Biol. 2007;33:1592-8 pubmed
    ..Only one tumor per rat was treated by ultrasound. The first group received injection of Evans blue, followed by UTMD...
  12. Wooddell C, Zhang G, Griffin J, Hegge J, Huss T, Wolff J. Use of Evans blue dye to compare limb muscles in exercised young and old mdx mice. Muscle Nerve. 2010;41:487-99 pubmed publisher
    b>Evans blue dye (EBD) is used to mark damaged and permeable muscle fibers in mouse models of muscular dystrophy and as an endpoint in therapeutic trials...
  13. Kaptanoglu E, Okutan O, Akbiyik F, Solaroglu I, Kilinc A, Beskonakli E. Correlation of injury severity and tissue Evans blue content, lipid peroxidation and clinical evaluation in acute spinal cord injury in rats. J Clin Neurosci. 2004;11:879-85 pubmed
    ..permeability occurring in association with graded acute spinal cord injury and to determine whether tissue Evans blue content is a useful indicator of the severity of spinal cord injury...
  14. Rakos G, Kis Z, Nagy D, Lur G, Farkas T, Hortobagyi T, et al. Evans Blue fluorescence permits the rapid visualization of non-intact cells in the perilesional rim of cold-injured rat brain. Acta Neurobiol Exp (Wars). 2007;67:149-54 pubmed
    ..which can be readily visualized if the plasma albumin was previously bound to fluorescent tracers, such as Evans Blue (EB)...
  15. Yang F, Liu S, Ho F, Chang C. Effect of ultrasound contrast agent dose on the duration of focused-ultrasound-induced blood-brain barrier disruption. J Acoust Soc Am. 2009;126:3344-9 pubmed publisher
    ..BBB integrity was evaluated via femoral vein injection of Evans Blue (EB) while the rats were anesthetized...
  16. Miller D, Li P, Dou C, Armstrong W, Gordon D. Evans blue staining of cardiomyocytes induced by myocardial contrast echocardiography in rats: evidence for necrosis instead of apoptosis. Ultrasound Med Biol. 2007;33:1988-96 pubmed
    High mechanical index (MI) echocardiography with contrast agent has been shown to induce Evans blue staining of cardiomyocytes, seen 1 d after exposure, in addition to contraction band necrosis, seen immediately after exposure...
  17. Kamath A, Chauhan A, Kisucka J, Dole V, Loscalzo J, Handy D, et al. Elevated levels of homocysteine compromise blood-brain barrier integrity in mice. Blood. 2006;107:591-3 pubmed
    ..This was due at least in part to increased expression of P-selectin. BBB permeability was measured by Evans blue dye permeation and was found to be 25% greater in the Cbs(+/-) cortex compared with wild-type controls...
  18. Yang F, Wang H, Lin G, Lin H, Wong T. Evaluation of the increase in permeability of the blood-brain barrier during tumor progression after pulsed focused ultrasound. Int J Nanomedicine. 2012;7:723-30 pubmed publisher
  19. Mei J, Cheng Y, Song Y, Yang Y, Wang F, Liu Y, et al. Experimental study on targeted methotrexate delivery to the rabbit brain via magnetic resonance imaging-guided focused ultrasound. J Ultrasound Med. 2009;28:871-80 pubmed
  20. Chen K, Wei V, Yen L, Poon K, Liu Y, Cheng K, et al. Intravenous mannitol does not increase blood-brain barrier permeability to inert dyes in the adult rat forebrain. Neuroreport. 2013;24:303-7 pubmed publisher
    ..mannitol (ICA-M) is known to potently open the blood-brain barrier (BBB) to serum protein tracers such as the Evans blue dye (EBD)...
  21. Ujiie M, Dickstein D, Carlow D, Jefferies W. Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model. Microcirculation. 2003;10:463-70 pubmed
  22. Donzelli J, Brady S, Wesling M, Craney M. Simultaneous modified Evans blue dye procedure and video nasal endoscopic evaluation of the swallow. Laryngoscope. 2001;111:1746-50 pubmed
    To investigate the results of the modified Evans blue dye test (MEBD) aspiration detection rate to the video nasal endoscopic examination of the swallow (VEES) during simultaneous studies with direct viewing of the subglottis through the ..
  23. Esposito P, Gheorghe D, Kandere K, Pang X, Connolly R, Jacobson S, et al. Acute stress increases permeability of the blood-brain-barrier through activation of brain mast cells. Brain Res. 2001;888:117-127 pubmed
    ..These results expand the pathophysiology of mast cells and implicate them in CNS disorders, that may possibly be induced or exacerbated by stress...
  24. Straub V, Rafael J, Chamberlain J, Campbell K. Animal models for muscular dystrophy show different patterns of sarcolemmal disruption. J Cell Biol. 1997;139:375-85 pubmed
    ..b>Evans blue, a low molecular weight diazo dye, does not cross into skeletal muscle fibers in normal mice...
  25. Dallal M, Chang S. Evans blue dye in the assessment of permeability-surface area product in perfused rat lungs. J Appl Physiol (1985). 1994;77:1030-5 pubmed
    b>Evans blue dye (EBD) has been used extensively as a marker of extravascular protein leakage...
  26. Schols D, Pauwels R, Desmyter J, De Clercq E. Dextran sulfate and other polyanionic anti-HIV compounds specifically interact with the viral gp120 glycoprotein expressed by T-cells persistently infected with HIV-1. Virology. 1990;175:556-61 pubmed
    ..e., dextran sulfate, pentosan polysulfate, heparin, aurintricarboxylic acid (ATA), suramin, and Evans blue, which are known to inhibit the adsorption of HIV particles to CD4+ cells, prevented the binding of anti-gp120 ..
  27. Grond S, Demopulos G, Herz J, Pierce Palmer P. Inhibition of synovial plasma extravasation by preemptive administration of an antiinflammatory irrigation solution in the rat knee. Anesth Analg. 2001;92:1301-6 pubmed
    ..We conclude that acute synovial inflammation, which is induced and maintained by multiple mediators, can be substantially inhibited only by the preemptive administration of a drug combination that targets multiple inflammatory mediators...
  28. Murphy C, Lever M. A ratiometric method of autofluorescence correction used for the quantification of Evans blue dye fluorescence in rabbit arterial tissues. Exp Physiol. 2002;87:163-70 pubmed
    b>Evans blue dye (EBD) conjugates with albumin in the circulation and is frequently used to measure vascular protein leakage...
  29. Hellal F, Bonnefont Rousselot D, Croci N, Palmier B, Plotkine M, Marchand Verrecchia C. Pattern of cerebral edema and hemorrhage in a mice model of diffuse brain injury. Neurosci Lett. 2004;357:21-4 pubmed
    ..This event was associated with electrolyte imbalance such as Na(+) increase within 24 h. Prominent Evans blue extravasation was also observed from 1 to 6 h post-injury...
  30. Hamer P, McGeachie J, Davies M, Grounds M. Evans Blue Dye as an in vivo marker of myofibre damage: optimising parameters for detecting initial myofibre membrane permeability. J Anat. 2002;200:69-79 pubmed
    b>Evans Blue Dye (EBD) is widely used to study cellular membrane permeability and has recently been utilised in mdx mice to identify permeable skeletal myofibres that have become damaged as a result of muscular dystrophy...
  31. Nyberg F, Sharma H. Repeated topical application of growth hormone attenuates blood-spinal cord barrier permeability and edema formation following spinal cord injury: an experimental study in the rat using Evans blue, ([125])I-sodium and lanthanum tracers. Amino Acids. 2002;23:231-9 pubmed
    ..Traumatised rats treated with saline exhibited marked edema formation and extravasation of Evans blue and ([125])Iodine tracers in the spinal cord...
  32. Wang Y, Mitchell J, Sharma M, Gabriel A, Moriyama K, Palmer P. Leukotrienes mediate 5-hydroxytryptamine-induced plasma extravasation in the rat knee joint via CysLT-type receptors. Inflamm Res. 2004;53:66-71 pubmed
    ..The aim of this study was to investigate whether leukotrienes synthesized by 5-lipoxygenase (5-LO) and acting via leukotriene (LT) receptors contribute to 5-hydroxytryptamine (5-HT)-induced knee joint plasma extravasation (PE)...
  33. Verbrugge S, Vazquez de Anda G, Gommers D, Neggers S, Sorm V, Böhm S, et al. Exogenous surfactant preserves lung function and reduces alveolar Evans blue dye influx in a rat model of ventilation-induced lung injury. Anesthesiology. 1998;89:467-74 pubmed
    ..To further elucidate the role of surfactant changes, the authors tested the effect of different doses of exogenous surfactant preceding high peak inspiratory lung volumes on lung function and lung permeability...
  34. Xu Q, Qaum T, Adamis A. Sensitive blood-retinal barrier breakdown quantitation using Evans blue. Invest Ophthalmol Vis Sci. 2001;42:789-94 pubmed
    This study investigated whether a nonradioactive dye, Evans blue, can be adapted as a safe alternative to the isotope-dilution method for quantitating blood-retinal barrier breakdown.
  35. Beery R, Haimsohn M, Wertheim N, Hemi R, Nir U, Karasik A, et al. Activation of the insulin-like growth factor 1 signaling pathway by the antiapoptotic agents aurintricarboxylic acid and evans blue. Endocrinology. 2001;142:3098-107 pubmed
    ..Here we show that ATA and a polysulfonated aromatic compound, Evans blue (EB), similar to IGF-I, promote survival and increase proliferation of MCF-7 cells in serum-free culture medium...
  36. Lam F, Wong H, Ng E. Time course and substance P effects on the vascular and morphological changes in adjuvant-induced monoarthritic rats. Int Immunopharmacol. 2004;4:299-310 pubmed
    ..These findings confirm that intra-articular injection of a low dose of FCA could elicit discrete monoarthritis in rat knees, and substance P could exacerbate and spread the early signs of this disease to the contralateral knees...
  37. Sharma H, Westman J, Navarro J, Dey P, Nyberg F. Probable involvement of serotonin in the increased permeability of the blood-brain barrier by forced swimming. An experimental study using Evans blue and 131I-sodium tracers in the rat. Behav Brain Res. 1995;72:189-96 pubmed
    ..FS (at a water temperature of 30 +/- 1 degrees C) for 30 min, increased the permeability of the BBB to Evans blue albumin (EBA) and 131I-sodium in six and nine brain regions, respectively...
  38. Sahin D, Ilbay G, Ates N. Changes in the blood-brain barrier permeability and in the brain tissue trace element concentrations after single and repeated pentylenetetrazole-induced seizures in rats. Pharmacol Res. 2003;48:69-73 pubmed
    ..As a marker of blood-brain barrier (B-BB) permeability changes, Evans Blue (EB) dye was used. Seizure activity was observed and seizure patterns and convulsion times were recorded...
  39. Ning R, Chopp M, Yan T, Zacharek A, Zhang C, Roberts C, et al. Tissue plasminogen activator treatment of stroke in type-1 diabetes rats. Neuroscience. 2012;222:326-32 pubmed publisher
    ..The increased inflammatory response may contribute to the failed neuroprotective effects of tPA treatment in T1DM rats. ..
  40. Ferrero M. In vivo vascular leakage assay. Methods Mol Med. 2004;98:191-8 pubmed
    ..the portal vein or the renal artery, respectively, by intravascular injection of a blue dye (trypan blue or Evans blue) combined with albumin...
  41. Ahmadi Eslamloo H, Dehghani G, Moosavi S. Long-term treatment of diabetic rats with vanadyl sulfate or insulin attenuate acute focal cerebral ischemia/reperfusion injury via their antiglycemic effect. Metab Brain Dis. 2018;33:225-235 pubmed publisher
    ..However, they caused similar decrements in levels of Evans blue dye extravastion, edema, infarct volume and malondialdehyde in ischemic/reperfused cerebral hemisphere...
  42. Moxley M, Baird T, Corbett J. Adoptive transfer of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2000;279:L985-93 pubmed
    ..This lung injury is characterized by increased alveolar-arterial oxygen difference and extravasation of Evans blue dye (EBD) into lungs of recipient rats...
  43. Zhang M, Cui Z, Cui H, Cao Y, Zhong C, Wang Y. Astaxanthin alleviates cerebral edema by modulating NKCC1 and AQP4 expression after traumatic brain injury in mice. BMC Neurosci. 2016;17:60 pubmed publisher
    ..compared to vehicle ameliorated neurologic dysfunctions after day 3 and alleviated cerebral edema and Evans blue extravasation at 24 h (p < 0.05)...
  44. Gao X, Wu Q, Kiriazis H, Su Y, Han L, Pearson J, et al. Microvascular leakage in acute myocardial infarction: characterization by histology, biochemistry, and magnetic resonance imaging. Am J Physiol Heart Circ Physiol. 2017;312:H1068-H1075 pubmed publisher
    ..I/R was induced surgically in mice. MVL was determined by administrating the microvascular permeability tracer Evans blue (EB) and/or gadolinium-diethylenetriaminepentaacetic acid contrast...
  45. Kim T, Chae S, Kim H, Jung H. Effect of recombinant vascular endothelial growth factor on experimental otitis media with effusion. Acta Otolaryngol. 2005;125:256-9 pubmed
    ..ear fluid was aspirated and the vascular permeability of the middle ear mucosa was measured by means of the Evans Blue vital dye technique...
  46. Kaminski A, Kasch C, Zhang L, Kumar S, Sponholz C, Choi Y, et al. Endothelial nitric oxide synthase mediates protective effects of hypoxic preconditioning in lungs. Respir Physiol Neurobiol. 2007;155:280-5 pubmed
    ..assessed by myeloperoxidase (MPO) activity, associated with a mild further increase in endothelial permeability (Evans Blue extravasation)...
  47. Ye J, Piao H, Jiang J, Jin G, Zheng M, Yang J, et al. Polydatin inhibits mast cell-mediated allergic inflammation by targeting PI3K/Akt, MAPK, NF-?B and Nrf2/HO-1 pathways. Sci Rep. 2017;7:11895 pubmed publisher
    ..PD dose-dependently reduced the pigmentation of Evans blue in the PCA model and decreased the concentration of serum histamine in PSA model, and attenuated the ..
  48. Li Y, Xu L, Zeng K, Xu Z, Suo D, Peng L, et al. Propane-2-sulfonic acid octadec-9-enyl-amide, a novel PPAR?/? dual agonist, protects against ischemia-induced brain damage in mice by inhibiting inflammatory responses. Brain Behav Immun. 2017;66:289-301 pubmed publisher
    ..Blood brain barrier (BBB) disruption was evaluated by Evans blue (EB) and FITC-dextran leakages at 6h after reperfusion...
  49. Suzuki Y, Lyons J, Yeung A, Ikeno F. In vivo porcine model of reperfused myocardial infarction: in situ double staining to measure precise infarct area/area at risk. Catheter Cardiovasc Interv. 2008;71:100-7 pubmed
    ..Myocardial infarction was successfully induced in all 72 animals and in situ double-staining with Evans blue dye and 2,3,5-triphenyltetrazolium chloride was performed to delineate area at risk for ischemia and infarcted ..
  50. Gómez González B, Hurtado Alvarado G, Esqueda Leon E, Santana Miranda R, Rojas Zamorano J, Velazquez Moctezuma J. REM sleep loss and recovery regulates blood-brain barrier function. Curr Neurovasc Res. 2013;10:197-207 pubmed
    ..present report aimed to study the consequences of REM sleep restriction upon blood-brain barrier permeability to Evans blue. REM sleep restriction was induced by the multiple platform technique; male rats were REM sleep restricted 20h ..
  51. Greco T, Hovda D, Prins M. The effects of repeat traumatic brain injury on the pituitary in adolescent rats. J Neurotrauma. 2013;30:1983-90 pubmed publisher
    ..h, 72 h, 1 week, and 1 month after injury, and vascular permeability of the pituitary gland was quantified via Evans Blue dye extravasation...
  52. Martins A, Rodrigues L, Cesário F, de Oliveira M, Tintino C, Castro F, et al. Anti-edematogenic and anti-inflammatory activity of the essential oil from Croton rhamnifolioides leaves and its major constituent 1,8-cineole (eucalyptol). Biomed Pharmacother. 2017;96:384-395 pubmed publisher
    ..induced by: carrageenan, dextran, histamine and arachidonic acid, while vascular permeability was determined by Evans blue extravasation and chronic anti-inflammatory activity by granuloma induction using the implantation of cotton ..
  53. Tang C, Xue H, Bai C, Fu R, Wu A. The effects of Tanshinone IIA on blood-brain barrier and brain edema after transient middle cerebral artery occlusion in rats. Phytomedicine. 2010;17:1145-9 pubmed publisher
    ..Furthermore, Tan IIA significantly decreased BBB permeability to Evans blue, suppressed the expression of intercellular adhesion molecule-1 (ICAM-1), matrix metalloproteinase-9 (MMP-9), ..
  54. Liu H, Yang M, Qiu G, Zhuo F, Yu W, Sun S, et al. Aquaporin 9 in rat brain after severe traumatic brain injury. Arq Neuropsiquiatr. 2012;70:214-20 pubmed
    ..To reveal the expression and possible roles of aquaporin 9 (AQP9) in rat brain, after severe traumatic brain injury (TBI)...
  55. Lovering R, McMillan A, Gullapalli R. Location of myofiber damage in skeletal muscle after lengthening contractions. Muscle Nerve. 2009;40:589-94 pubmed publisher
    ..Results suggest that myofiber injury occurs primarily in the middle portion of the muscle, with interstitial edema in the middle and distal portions...
  56. Zhang Z, Xia C, Xue Y, Liu Y. Synergistic effect of low-frequency ultrasound and low-dose bradykinin on increasing permeability of the blood-tumor barrier by opening tight junction. J Neurosci Res. 2009;87:2282-9 pubmed publisher
    ..The BTB permeability was assessed by Evans blue extravasation...
  57. Shulyakov A, Benour M, Del Bigio M. Surface dialysis after experimental brain injury: modification of edema fluid flow in the rat model. J Neurosurg. 2008;109:670-7 pubmed publisher
    ..This study was undertaken to determine if dialysis of damaged brain surface can reduce cerebrospinal fluid (CSF) pressure and progressive brain edema. The authors secondarily determined if local brain cooling was simultaneously possible...
  58. Kawanishi M, Kawai N, Nakamura T, Luo C, Tamiya T, Nagao S. Effect of delayed mild brain hypothermia on edema formation after intracerebral hemorrhage in rats. J Stroke Cerebrovasc Dis. 2008;17:187-95 pubmed publisher
    ..To examine the protective mechanism of BH, blood-brain barrier (BBB) permeability to Evans blue, accumulation of polymorphonuclear leukocyte, and oxidative DNA damage in the lesion were compared between ..
  59. Wang G, Tang B, Traub R. Differential processing of noxious colonic input by thoracolumbar and lumbosacral dorsal horn neurons in the rat. J Neurophysiol. 2005;94:3788-94 pubmed
    ..These differences may contribute to the functional dichotomy between the TL and LS spinal segments in processing acute and inflammatory colorectal pain...
  60. Yee K, Soo K, Olivo M. Anti-angiogenic effects of Hypericin-photodynamic therapy in combination with Celebrex in the treatment of human nasopharyngeal carcinoma. Int J Mol Med. 2005;16:993-1002 pubmed
    ..Thus, suggesting that the time of initial administration of CX post-PDT is an important factor for effective tumor control...
  61. Kornfeld S, Goupille C, Vibet S, Chevalier S, Pinet A, Lebeau J, et al. Reducing endothelial NOS activation and interstitial fluid pressure with n-3 PUFA offset tumor chemoresistance. Carcinogenesis. 2012;33:260-7 pubmed publisher
    ..and during docetaxel treatment [every 2 h up to 1 week (W(+1)) for interstitial fluid pressure, at W(+1) for Evans blue extravasation and at W(+2) and W(+6) for ultrasounds]...
  62. Gu Y, Zheng G, Xu M, Li Y, Chen X, Zhu W, et al. Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury. J Neurochem. 2012;120:147-56 pubmed publisher
    ..The effects of L-NAME on MMPs activity and BBB permeability are partly mediated by preservation of cav-1...
  63. Hua X, Zhu L, Li R, Zhong H, Xue Y, Chen Z. Effects of diagnostic contrast-enhanced ultrasound on permeability of placental barrier: a primary study. Placenta. 2009;30:780-4 pubmed publisher
    ..To evaluate the effects of contrast-enhanced ultrasound (CEU) on the permeability of placental barrier primarily...
  64. Van Sluis G, Niers T, Esmon C, Tigchelaar W, Richel D, Buller H, et al. Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement. Blood. 2009;114:1968-73 pubmed publisher
    ..Moreover, endogenous APC prevents cancer cell-induced vascular leakage as assessed by the Evans Blue Dye assay, and SEW2871 treatment reversed MPC1609-dependent vascular leakage...
  65. Auais A, Wedde Beer K, Piedimonte G. Anti-inflammatory effect of albuterol enantiomers during respiratory syncytial virus infection in rats. Pediatr Pulmonol. 2005;40:228-34 pubmed
    ..Based on these data, we speculate that (R)-albuterol may be more effective than other adrenergic agents in the management of bronchiolitis...
  66. Miller D, Li P, Dou C, Gordon D, Edwards C, Armstrong W. Influence of contrast agent dose and ultrasound exposure on cardiomyocyte injury induced by myocardial contrast echocardiography in rats. Radiology. 2005;237:137-43 pubmed
  67. Green M, Farshid G, Kollias J, Chatterton B, Tsopelas C. The tissue distribution of Evans blue dye in a sheep model of sentinel node biopsy. Nucl Med Commun. 2006;27:695-700 pubmed
    Tc-Evans blue is a 'single dose' agent for lymphatic mapping combining radioactivity and blue dye for sentinel node identification. The mechanism and distribution of blue dye retention in the lymph node is not clearly understood.