dithizone

Summary

Summary: Chelating agent used for heavy metal poisoning and assay. It causes diabetes.

Top Publications

  1. Khan H, Ahmed M, Bhanger M. A simple spectrophotometric determination of trace level mercury using 1,5-diphenylthiocarbazone solubilized in micelle. Anal Sci. 2005;21:507-12 pubmed
    ..is presented for the rapid determination of mercury(II) at ultra-trace level using 1,5-diphenylthiocarbazone (dithizone) as a new micellar spectrophotometric reagent (lambdamax = 490 nm) in a slightly acidic (0.07 - 0...
  2. Shiroi A, Yoshikawa M, Yokota H, Fukui H, Ishizaka S, Tatsumi K, et al. Identification of insulin-producing cells derived from embryonic stem cells by zinc-chelating dithizone. Stem Cells. 2002;20:284-92 pubmed
    ..recently identified the emergence of cellular clusters within differentiated ES cell cultures by staining with dithizone (DTZ)...
  3. Kihara T, Ishihara T, Baba A, Iwata H. Effect of diphenylthiocarbazone (dithizone) on glutamate level in hippocampus preparation in vitro and in vivo. J Pharmacobiodyn. 1990;13:225-30 pubmed
    To assess the functional interaction between Zn2+ and glutamate in hippocampus, diphenylthiocarbazone (dithizone), a Zn2+ chelator, was used to alter the glutamate level in hippocampus in vitro and in vivo...
  4. Hansen W, Christie M, Kahn R, Norgaard A, Abel I, Petersen A, et al. Supravital dithizone staining in the isolation of human and rat pancreatic islets. Diabetes Res. 1989;10:53-7 pubmed
    b>Dithizone, a zinc chelating agent, is known to selectively stain the islets of Langerhans in the pancreas...
  5. Cestari A, Vieira E, Lopes E, da Silva R. Kinetics and equilibrium parameters of Hg(II) adsorption on silica-dithizone. J Colloid Interface Sci. 2004;272:271-6 pubmed
    Sílica-dithizone (Sil-dtz) was synthesized and used to adsorb Hg(II) in solution at pH 6.0. Increasing the temperature accelerates the mass transfer of Hg(II) to the silica surface...
  6. Garnuszek P, Licinska I, Fiedor P, Mazurek A. The synthesis, radioiodination and preliminary biological study of the new carboxylic derivatives of dithizone. Appl Radiat Isot. 1998;49:1563-71 pubmed
    Synthesis, characteristics and radioiodination of the new carboxylic derivatives of dithizone are described in this paper. We have applied the carboxy dithizones for preparation of radioactive compounds by coupling with [131I]-histamine...
  7. Sawada M, Takahashi K, Sawada S, Midorikawa O. Selective killing of Paneth cells by intravenous administration of dithizone in rats. Int J Exp Pathol. 1991;72:407-21 pubmed
    ..v.) injection of diphenylthiocarbazone (dithizone), a chelator forming a zinc dithizonate complex, in the rat. As soon as 5 min after the i.v...
  8. Mitchell C, Barnes M, Grimes L. Diethyldithiocarbamate and dithizone augment the toxicity of kainic acid. Brain Res. 1990;506:327-30 pubmed
    Male Fischer-344 rats were injected i.p. with diethyldithiocarbamate or dithizone 15 min after kainic acid (KA), s.c...
  9. Kohroki J, Muto N, Tanaka T, Itoh N, Inada A, Tanaka K. Induction of differentiation and apoptosis by dithizone in human myeloid leukemia cell lines. Leuk Res. 1998;22:405-12 pubmed
    We investigated the effect of diphenylthiocarbazone (dithizone) and its structurally related compounds on the differentiation and apoptosis of two human myeloid leukemia cell lines...

More Information

Publications93

  1. Sherman M, Bennett S, Hwang F, Sherman J, Bevins C. Paneth cells and antibacterial host defense in neonatal small intestine. Infect Immun. 2005;73:6143-6 pubmed
    ..b>Dithizone selectively damages Paneth cells, and when dithizone-treated newborn rats are infected enterally with ..
  2. Seno H, Sawada M, Fukuzawa H, Morita Y, Takaishi S, Hiai H, et al. Enhanced expression of transforming growth factor (TGF) -alpha precursor and TGF-beta1 during Paneth cell regeneration. Dig Dis Sci. 2001;46:1004-10 pubmed
    An intravenous injection of diphenylthiocarbazone (dithizone), a zinc chelator, induces selective killing and rapid regeneration of Paneth cells, which have a large amount of zinc in their cytoplasmic granules...
  3. Goldberg E, Eshchenko V, Bovt V. The diabetogenic and acidotropic effects of chelators. Exp Pathol. 1991;42:59-64 pubmed
    Diabetogenic and acidotropic effects of dithizone, 8-(p-toluenesulfonylamino)-quinoline and 8-(benzenesulfonylamino)-quinoline were studied in experiments on cats, rabbits, golden hamsters and mice...
  4. Bai H, Zhou Q, Xie G, Xiao J. Temperature-controlled ionic liquid-liquid-phase microextraction for the pre-concentration of lead from environmental samples prior to flame atomic absorption spectrometry. Talanta. 2010;80:1638-42 pubmed publisher
    ..In this experiment, lead was transferred into its complex using dithizone as chelating agent, and then entered into the infinite ionic liquid drops at high temperature...
  5. Nizamani S, Kazi T, Afridi H. Ultrasonic-energy enhance the ionic liquid-based dual microextraction to preconcentrate the lead in ground and stored rain water samples as compared to conventional shaking method. Ultrason Sonochem. 2018;40:265-270 pubmed publisher
    ..In the current proposed method, Pb+2 was complexed with a chelating agent (dithizone), whereas an ionic liquid (1-butyl-3-methylimidazolium hexafluorophosphate) was used for extraction purpose...
  6. Sawada M, Nishikawa M, Adachi T, Midorikawa O, Hiai H. A Paneth cell specific zinc-binding protein in the rat. Purification and immunohistochemical localization. Lab Invest. 1993;68:338-44 pubmed
    ..Our previous study showed that a single intravenous injection of diphenylthiocarbazone (dithizone), a zinc chelator, forms zinc-dithizonate complexes in the cytoplasm of Paneth cells to ensure rapid and ..
  7. Jafarian A, Taghikani M, Abroun S, Allahverdi A, Lamei M, Lakpour N, et al. The Generation of Insulin Producing Cells from Human Mesenchymal Stem Cells by MiR-375 and Anti-MiR-9. PLoS ONE. 2015;10:e0128650 pubmed publisher
    ..After 21 days of induction, islet-like clusters containing insulin producing cells (IPCs) were confirmed by dithizone (DTZ) staining...
  8. Loennecken I, Muller W, Firsching R. Topochemical demonstration of zinc in meningiomas. Acta Neuropathol. 1987;74:81-3 pubmed
    In agreement with the atomic absorption tests, histochemical demonstration of zinc in meningiomas using the dithizone method revealed a higher level of zinc in fibromatous meningiomas than in its meningiotheliomatous variant...
  9. Xie Q, Huang H, Xu B, Dong X, Gao S, Zhang B, et al. Human bone marrow mesenchymal stem cells differentiate into insulin-producing cells upon microenvironmental manipulation in vitro. Differentiation. 2009;77:483-91 pubmed publisher
    ..induction human BM-MSCs formed spheroid islet-like clusters containing IPCs, which was further confirmed by dithizone (DTZ) staining and electron microscopy...
  10. Hashemi Moghaddam H, Saber Tehrani M. Sensitive mercury speciation by reversed-phase column high-performance liquid chromatography with UV-visible detection after solid-phase extraction using 6-mercaptopurine and dithizone. J AOAC Int. 2008;91:1453-8 pubmed
    ..The complex was then treated with ammoniacal dithizone solution, and the complexes of inorganic and organic mercury with dithizone were eluted by methanol...
  11. Şuşman S, Rus Ciucă D, Soriţău O, Ciortea R, Gîrlovanu M, Mihu D, et al. Human placenta - stem cell source for obtaining pancreatic progenitors. Rom J Morphol Embryol. 2015;56:505-10 pubmed
    ..They were positively for dithizone staining and expressed insulin as shown by immunocytochemistry...
  12. Kis M, Sipka G, Maroti P. Stoichiometry and kinetics of mercury uptake by photosynthetic bacteria. Photosynth Res. 2017;132:197-209 pubmed publisher
    ..of mercury bioaccumulation are studied in intact cells of photosynthetic bacteria by use of analytical (dithizone) assay and physiological photosynthetic markers (pigment content, fluorescence induction, and membrane potential)..
  13. Yu Y, Bian J, Gu D. Transplantation of insulin-producing cells to treat diabetic rats after 90% pancreatectomy. World J Gastroenterol. 2015;21:6582-90 pubmed publisher
    ..Differentiated cells were examined by dithizone (DTZ) staining, reverse transcription-polymerase chain reaction (RT-PCR), and real-time RT-PCR...
  14. Deng J, Kang X, Chen L, Wang Y, Gu Z, Lu Z. A nanofiber functionalized with dithizone by co-electrospinning for lead (II) adsorption from aqueous media. J Hazard Mater. 2011;196:187-93 pubmed publisher
    ..The nanofiber had a polystyrene (PS) backbone, which was functionalized with dithizone (DZ) by co-electrospinning of a PS solution containing DZ...
  15. Santos I, Mesquita R, Rangel A. Screening of cadmium and lead in potentially contaminated waters using a spectrophotometric sequential injection lab-on-valve methodology. Talanta. 2015;143:359-365 pubmed publisher
    ..To attain the biparametric determination, dithizone was chosen as the spectrophotometric reagent as it forms a colored complex with both metal ions, at different pH ..
  16. Cui W, Gu Y, Miyamoto M, Tanaka M, Xu B, Imamura M, et al. Novel method for isolation of adult porcine pancreatic islets with two-stage digestion procedure. Cell Transplant. 1999;8:391-8 pubmed
    ..This two-stage APII method with its new enzyme solution may facilitate the future use of porcine islets in clinical xenotransplantation trials. ..
  17. Brandão I, Zini E, Reusch C, Lutz T, Osto M. Establishment of a protocol for the isolation of feline pancreatic islets. Physiol Behav. 2018;186:79-81 pubmed publisher
    ..The enzymatic digestion was combined with mechanical disruption and controlled by dithizone staining. Purification was performed by filtration and handpicking...
  18. Huang K, Chen Y, Zhou F, Zhao X, Liu J, Mei S, et al. Integrated ion imprinted polymers-paper composites for selective and sensitive detection of Cd(II) ions. J Hazard Mater. 2017;333:137-143 pubmed publisher
    ..without complex sample pretreatment and expensive instrument, due to the selective recognition, formation of dithizone-cadmium complexes and light transmission ability...
  19. Ali J, Tuzen M, Kazi T. Evaluation of Mercury in Environmental Samples by a Supramolecular Solvent-Based Dispersive Liquid-Liquid Microextraction Method Before Analysis by a Cold Vapor Generation Technique. J AOAC Int. 2017;100:782-788 pubmed publisher
    ..The HgII in acidic media forms a complex with dithizone (DTz) in the presence of supramolecular solvent (tetrahydrofuran and 1-undecanol), forming reverse micelles...
  20. Shayesteh T, Khajavi F, Khosroshahi A, Mahjub R. Development and validation of a novel, simple, and accurate spectrophotometric method for the determination of lead in human serum. Environ Monit Assess. 2016;188:7 pubmed publisher
    ..The lead content was extracted into the organic phase containing dithizone as a complexion reagent and the dithizone-Pb(II) complex was formed and approved by visible spectrophotometry at ..
  21. Rajesh N, Gurulakshmanan G. Solid phase extraction and spectrophotometric determination of mercury by adsorption of its diphenylthiocarbazone complex on an alumina column. Spectrochim Acta A Mol Biomol Spectrosc. 2008;69:391-5 pubmed
    ..The preconcentration factor attainable for quantitative recovery (>95%) of mercury(II) was 100 for a 1000mL sample volume. ..
  22. Deshpande P, Dapkekar A, Oak M, Paknikar K, Rajwade J. Zinc complexed chitosan/TPP nanoparticles: A promising micronutrient nanocarrier suited for foliar application. Carbohydr Polym. 2017;165:394-401 pubmed publisher
    ..of zinc ions from foliar applied Zn-CNP into the leaf and seed tissue was demonstrated using zinquin and dithizone stains, respectively...
  23. Howell G, Frederickson C, Danscher G. Evidence from dithizone and selenium zinc histochemistry that perivascular mossy fiber boutons stain preferentially "in vivo". Histochemistry. 1989;92:121-5 pubmed
    This paper describes a perivascular staining pattern that is obtained when dithizone or sodium selenite are used to label zinc intravitally...
  24. Dionisio G, Uddin M, Vincze E. Enrichment and Identification of the Most Abundant Zinc Binding Proteins in Developing Barley Grains by Zinc-IMAC Capture and Nano LC-MS/MS. Proteomes. 2018;6: pubmed publisher
    ..Polyacrylamide Gel Electrophoresis (SDS-PAGE) followed by polyvinylidene fluoride (PVDF) membrane blotting and dithizone staining...
  25. Montereali M, Pinto V, Schiavella F, Armiento G, Angelone M, Crovato C, et al. A field screening test for the assessment of concentrations and mobility of potentially toxic elements in soils: a case study on urban soils from Rome and Novi Sad. Environ Monit Assess. 2017;189:466 pubmed publisher
    ..extraction of the soil sample with a buffer solution, followed by the titration of the extracted solution with dithizone to determine the contents of bi-valent heavy metals (such as Pb, Cu, Zn, and Cd)...
  26. Xiao S, Chen J, Shen Y. [Determination of lead in water samples by graphite furnace atomic absorption spectrometry after cloud point extraction with dithizone]. Guang Pu Xue Yu Guang Pu Fen Xi. 2006;26:955-8 pubmed
    Cloud point extraction was used for the preconcentration of lead after the formation of a complex with dithizone in the presence of surfactant Triton X-114, and then the lead was determined by graphite furnace atomic absorption ..
  27. Ntoi L, Buitendach B, von Eschwege K. Seven Chromisms Associated with Dithizone. J Phys Chem A. 2017;: pubmed publisher
    ..b>Dithizone and its derivatives and complexes are, to our knowledge, probably the most "colorful" compound, being responsive ..
  28. Yin C, Iqbal J, Hu H, Liu B, Zhang L, Zhu B, et al. Sensitive determination of trace mercury by UV-visible diffuse reflectance spectroscopy after complexation and membrane filtration-enrichment. J Hazard Mater. 2012;233-234:207-12 pubmed publisher
    ..The complexation reagent dithizone was firstly injected into the properly buffered solution with vigorous stirring, which started a simultaneous ..
  29. Słomka A, Kuta E, Szarek Łukaszewska G, Godzik B, Kapusta P, Tylko G, et al. Violets of the section Melanium, their colonization by arbuscular mycorrhizal fungi and their occurrence on heavy metal heaps. J Plant Physiol. 2011;168:1191-9 pubmed publisher
    ..AMF might prevent the uptake of toxic levels of heavy metals into the plant organs. Dithizone staining indicated a differential deposition of heavy metals in tissues of heartsease...
  30. Santos I, Mesquita R, Rangel A. Micro solid phase spectrophotometry in a sequential injection lab-on-valve platform for cadmium, zinc, and copper determination in freshwaters. Anal Chim Acta. 2015;891:171-8 pubmed publisher
    ..The spectrophotometric determination is based on the colourimetric reaction between dithizone and the target metals, previously retained on NTA resin...
  31. Kawamura C, Kizaki M, Fukuchi Y, Ikeda Y. A metal chelator, diphenylthiocarbazone, induces apoptosis in acute promyelocytic leukemia (APL) cells mediated by a caspase-dependent pathway without a modulation of retinoic acid signaling pathways. Leuk Res. 2002;26:661-8 pubmed
    A metal chelator, diphenylthiocarbazone (dithizone), has been reported to induce differentiation and apoptosis of the human myeloid leukemia cell line HL-60, however, very little is known about the mechanism of dithizone-induced ..
  32. Sunitha M, Srikanth L, Santhosh Kumar P, Chandrasekhar C, Sarma P. In vitro differentiation potential of human haematopoietic CD34(+) cells towards pancreatic ?-cells. Cell Biol Int. 2016;40:1084-93 pubmed publisher
    ..Distinct morphological changes of differentiated cells were observed on staining with dithizone (DTZ) and expression of PDX1, insulin and synaptophysin was confirmed by immunocytochemistry...
  33. Noguchi H, Naziruddin B, Shimoda M, Fujita Y, Chujo D, Takita M, et al. Induction of insulin-producing cells from human pancreatic progenitor cells. Transplant Proc. 2010;42:2081-3 pubmed publisher
    ..We also tested whether growth factors and protein transduction of pancreatic and duodenal homeobox factor-1 (PDX-1) and BETA2/NeuroD into human pancreatic stem/progenitor cells induced insulin or pancreas-related gene expressions...
  34. Tavallali H, Deilamy Rad G, Parhami A, Mousavi S. A novel development of dithizone as a dual-analyte colorimetric chemosensor: detection and determination of cyanide and cobalt (II) ions in dimethyl sulfoxide/water media with biological applications. J Photochem Photobiol B. 2013;125:121-30 pubmed publisher
    The behavior of dithizone (DTZ), an easily available dye has been studied for the first time in chromogenic sensing of CN(-) as an anionic species and for Co(2+) as a cationic species in DMSO/H2O media...
  35. Patai K, Balogh I, Szarvas Z. Clinicopathological problems of the local tissue effect of IUDs containing copper. III. Cytochemical study of the endometrial scrapings. Acta Chir Hung. 1989;30:139-44 pubmed
    ..For the investigations, dithizone, salicylaldoxime, rubeanic acid as well as dimethylglyoxime were used...
  36. Fiedor P, Rowinski W, Licinska I, Mazurek A, Hardy M. The survival identification of pancreatic islets of Langerhans. In vitro and in vivo effects of two dithizone preparations on staining of rat and human islets of Langerhans-preliminary study (Part I). Acta Pol Pharm. 1995;52:431-6 pubmed
    b>Dithizone (DTZ) which selectively stains islets of Langerhans in vitro has a diagnostic potential in the in vivo identification of viable transplanted pancreatic islets...
  37. Kuo C, Herrod H, Burghen G. Formation of pseudoislets from human pancreatic cultures. Pancreas. 1992;7:320-5 pubmed
    ..Scattered within these monolayers were insulin-positive cells, as detected by immunocytochemical and dithizone staining...
  38. Attiyat A, Matkovich C, Christian G. Flame atomic absorption determination of manganese in whole blood using solvent extraction into acetone. Am Ind Hyg Assoc J. 1988;49:244-7 pubmed
    ..Iron is removed first by solvent extraction from the acid solution with 100 ppm dithizone in acetone. The pH of the aqueous phase is adjusted to 8.0 with 0.2 mL of 0...
  39. Liu Z, Zhu Z, Zheng H, Hu S. Plasma jet desorption atomization-atomic fluorescence spectrometry and its application to mercury speciation by coupling with thin layer chromatography. Anal Chem. 2012;84:10170-4 pubmed publisher
    ..7 pg. The combination of TLC with PJDA-AFS provides a simple, cost-effective, relatively high-throughput way for mercury speciation...
  40. Moghadam Zadeh H, Ahmadvand P, Behbahani A, Amini M, Sayar O. Dithizone-modified graphene oxide nano-sheet as a sorbent for pre-concentration and determination of cadmium and lead ions in food. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32:1851-7 pubmed publisher
    Graphene oxide nano-sheet was modified with dithizone as a novel sorbent for selective pre-concentration and determination of Cd(II) and Pb(II) in food...
  41. Zhang C, Sherman M, Prince L, Bader D, Weitkamp J, Slaughter J, et al. Paneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like injury in the small intestine of immature mice. Dis Model Mech. 2012;5:522-32 pubmed publisher
    ..this loss in the intestine of postnatal day (P)14-P16 (immature) mice by treating them with the zinc chelator dithizone. Intestines from dithizone-treated animals retained approximately half the number of Paneth cells compared with ..
  42. Anesini C, Genaro A, Cremaschi G, Sterin Borda L, Borda E. Antimitogenic effect of Larrea divaricata Cav.: participation in arachidonate metabolism. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1999;122:245-52 pubmed
    ..Inhibitor studies of arachidonate pathway suggest that the proliferative effect of the extract is due to the activation of lipoxygenase metabolism, while the inhibitory action could be a direct effect...
  43. Shrivastaw K, Singh S. A new method for spectrophotometric determination of thiomersal in biologicals. Biologicals. 1995;23:65-9 pubmed
    A coloured complex formed with thiomersal by the action of dithizone, acetone, water and sodium hydroxide has been described and developed to quantitate even less than a microgram of thiomersal in biologicals...
  44. Ishii K, Sato M, Akita M, Tomita H. Localization of zinc in the rat submandibular gland and the effect of its deficiency on salivary secretion. Ann Otol Rhinol Laryngol. 1999;108:300-8 pubmed
    ..a zinc-deficient diet, and a rat model of acute zinc deficiency, prepared by administration of a zinc chelator, dithizone. In rats with chronic zinc deficiency, the granule production in the granular duct cells was decreased, but the ..
  45. Grabarić Z, Iveković D, Sipos L, Grabarić B. Improved signals ratio resolution method by optimization of resolution function--simultaneous determination of Cu(II) and Cd(II) in water samples. J AOAC Int. 1999;82:1185-96 pubmed
    ..Copper was determined in the mixture with ca 20-fold excess of cadmium, and cadmium was determined in ca 10-fold excess of copper at submicromolar concentration levels...
  46. Lukasiewicz A, Wozniak I, Fiedor P, Rowinski W, Mazurek A, Licinska I. Iodo-derivatives of dithizone with potential diagnostic application. Acta Pol Pharm. 1994;51:513-5 pubmed
    The mono and diiodo-derivatives of dithizone labelled with radioactive 131I isotope were obtained. Those compounds can be used for diagnostic of pancreas and other organs to monitor pathological states.
  47. Rajesh N, Hari M. Spectrophotometric determination of inorganic mercury (II) after preconcentration of its diphenylthiocarbazone complex on a cellulose column. Spectrochim Acta A Mol Biomol Spectrosc. 2008;70:1104-8 pubmed
    ..The method was also applied to the analysis of mercury content in city waste incineration ash (CRM176). The relative standard deviation of the method was found to be 3.5%...
  48. Dzhafarov A, Kasimov E, Mamedov S. Regulation of lipid peroxidation in the retina under the effect of bright light. Bull Exp Biol Med. 2011;150:700-1 pubmed
    ..A complex of natural and synthetic antioxidants was most efficient in correcting LPO under conditions of exposure to bright light...
  49. Macias P, Zamora R, Pinto M, Gutierrez Merino C. Comparative fluorescence properties of lipoxygenases. Comp Biochem Physiol B. 1988;89:531-7 pubmed
    ..5. It is suggested that the fluorescence above 600 nm reveals the presence of aromatic amino acids located near or at the catalytic center...
  50. Lembert N, Wesche J, Petersen P, Doser M, Becker H, Ammon H. Areal density measurement is a convenient method for the determination of porcine islet equivalents without counting and sizing individual islets. Cell Transplant. 2003;12:33-41 pubmed
    ..Purified islets were stained with dithizone and were repeatedly pictured under the microscope with random area selection...
  51. Lu Y, Taverna F, Tu R, Ackerley C, Wang Y, Roder J. Endogenous Zn(2+) is required for the induction of long-term potentiation at rat hippocampal mossy fiber-CA3 synapses. Synapse. 2000;38:187-97 pubmed
    ..The acute depletion of bouton Zn(2+) in the hippocampal slice with membrane-permeable Zn(2+) chelators, dithizone, or diethyldithiocarbamic acid (DEDTC) blocked the induction of mossy fiber LTP...
  52. Ruengsitagoon W, Chisvert A, Liawruangrath S. Flow injection spectrophotometric determination of lead using 1,5-diphenylthiocarbazone in aqueous micellar. Talanta. 2010;81:709-13 pubmed publisher
    ..0 and 8.0 microg ml(-1) of lead was 0.42% and 0.38%, respectively. The sample throughput was 80 h(-1). The proposed method has been satisfactorily applied to the determination of lead in water samples...
  53. Clark S, Borland K, Sherman S, Rusack T, Chick W. Staining and in vitro toxicity of dithizone with canine, porcine, and bovine islets. Cell Transplant. 1994;3:299-306 pubmed
    b>Dithizone (DTZ) is a recognized diabetogenic agent in vivo, and a supravital stain commonly used for identification of islets to be used for transplantation...
  54. Takahashi Y, Danwittayakul S, Suzuki T. Dithizone nanofiber-coated membrane for filtration-enrichment and colorimetric detection of trace Hg(II) ion. Analyst. 2009;134:1380-5 pubmed publisher
    b>Dithizone nanofiber-coated membranes (dithizone membranes), which are useful for sensitive and selective determination of Hg(II), were fabricated...
  55. Odani T, Kohroki J, Nakanishi T, Itoh N, Muto N, Tanaka K. Enhancement by dimethyl sulfoxide of 1,25-dihydroxyvitamin D3-induced differentiation in human promyelocytic HL-60 leukemia cells requires dimethyl sulfoxide-induced G0/G1 arrest. Res Commun Mol Pathol Pharmacol. 2000;108:381-91 pubmed
    ..Our study indicates that the synergistic effect of DMSO and 1,25(OH)2D3 on the induction of differentiation in HL-60 cells requires DMSO-induced G0/G1 arrest...
  56. Cui J, An M, Wang L. Nanocomposite-based rapid, visual, and selective luminescence turn-on assay for Hg2+ sensing in aqueous media. Talanta. 2013;115:512-7 pubmed publisher
    Composite nanospheres containing dithizone, luminescent LaVO4:Eu(3+) nanoparticles (NPs), and amphiphilic polymer have been composed for the rapid, selective, and visual luminescence turn-on detection of mercury ions (Hg(2+)) in water...
  57. Chandio Z, Talpur F, Khan H, Afridi H, Khaskheli G. Determination of cadmium and zinc in vegetables with online FAAS after simultaneous pre-concentration with 1,5-diphenylthiocarbazone immobilised on naphthalene. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30:110-5 pubmed publisher
    ..9914 and 0.9989 for Cd and Zn, respectively. The detection limits were calculated as three times the standard deviation of nine replicates of blanks: 0.00123 µg ml(-1) for Cd and 0.00176 µg ml(-1) for Zn...
  58. Wen X, Kong L, Chen M, Deng Q, Zhao X, Guo J. A new coupling of spectrophotometric determination with ultrasound-assisted emulsification dispersive liquid-liquid microextraction of trace silver. Spectrochim Acta A Mol Biomol Spectrosc. 2012;97:782-7 pubmed publisher
    ..45 ?g L(-1), with sensitivity enhancement factor (EF) of 35. The established method was applied to the determination of trace silver in real and certified reference samples with satisfactory analytical results...
  59. Vázquez M, Tascón M, Debán L. Determination of Pb(II) with a dithizone-modified carbon paste electrode. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2006;41:2735-46 pubmed
    A dithizone (DTZ) modified carbon paste electrode was developed for the sensitive and selective determination of Pb(II) using differential pulse anodic stripping voltammetry as well in batch as in FIA system...
  60. Ghanbari A, Khazaei M, Hashemi Tabar M, Rabzia A, Fathi F, Bayat P. Sonic hedgehog inhibition induces mouse embryonic stem cells to differentiate toward definitive endoderm. Indian J Exp Biol. 2013;51:201-7 pubmed
    ..In experimental group, the amount of GSC positive cells was somehow lower but it seems that there was no difference for Sox17. Shh inhibition induces ESCs to differentiate toward definitive endoderm by committing mesendodermal lineages...
  61. Perez Leiros C, Sterin Borda L, Borda E. Lymphocytes infiltration induces dysfunction in autoimmune myocarditis: role of SRS-A. J Mol Cell Cardiol. 1988;20:149-58 pubmed
    ..The way suggested for these phenomena to take place is, at least in part, the harmful effect of SRS-A released by hearts when specific antigens of myocardial tissue are recognized by autoimmune cells...
  62. Sartini R, Vidotti E, Oliveira C. Bead-injection determination of total mercury in river water samples. Anal Sci. 2003;19:1653-7 pubmed
    ..The introduction of a spectrophotometric reagent in the flow system leads to the formation of a colored Hg-dithizone complex on the surface of the bead, which is spectrophotometricaly monitored...
  63. Sato S, Ohgawara H, Nakagawa Y, Katagiri N, Fuchinoue S, Teraoka S, et al. A simple method for cryopreservation of purified adult pig pancreatic cells. Cell Transplant. 1996;5:S49-50 pubmed
    ..Number of dithizone-stained precryo. and postcryo. cells were 1.71 +/- 0.5 x 10(5) and 1.75 +/- 0...
  64. Choudhary S, Morrow J. Ligand libraries for the extraction of metal ions. Dynamic combinatorial and high-throughput screening methods. Methods Mol Biol. 2002;201:215-25 pubmed
  65. Minami K, Okuno M, Miyawaki K, Okumachi A, Ishizaki K, Oyama K, et al. Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. Proc Natl Acad Sci U S A. 2005;102:15116-21 pubmed
  66. von Eschwege K, Conradie J, Kuhn A. Dithizone and its oxidation products: a DFT, spectroscopic, and X-ray structural study. J Phys Chem A. 2011;115:14637-46 pubmed publisher
    Air oxidation of ortho-fluorodithizone resulted in the first X-ray resolved structure of a disulfide of dithizone, validating the last outstanding X-ray structure in the oxidation of dithizone, H(2)Dz, which proceeds via the disulfide, (..
  67. Liang P, Peng L. Ionic liquid-modified silica as sorbent for preconcentration of cadmium prior to its determination by flame atomic absorption spectrometry in water samples. Talanta. 2010;81:673-7 pubmed publisher
    ..7% at the 100 microg L(-1) Cd level. The method has been applied for the determination of trace amount of Cd in water samples with satisfactory results...
  68. Leng Y, Li Y, Gong A, Shen Z, Chen L, Wu A. Colorimetric response of dithizone product and hexadecyl trimethyl ammonium bromide modified gold nanoparticle dispersion to 10 types of heavy metal ions: understanding the involved molecules from experiment to simulation. Langmuir. 2013;29:7591-9 pubmed publisher
    A new kind of analytical reagent, hexadecyl trimethyl ammonium bromide (CTAB), and dithizone product-modified gold nanoparticle dispersion, is developed for colorimetric response to 10 types of heavy metal ions (M(n+)), including Cr(VI), ..
  69. Koh J, Suh S, Gwag B, He Y, Hsu C, Choi D. The role of zinc in selective neuronal death after transient global cerebral ischemia. Science. 1996;272:1013-6 pubmed
    ..The toxic influx of zinc may be a key mechanism underlying selective neuronal death after transient global ischemic insults...
  70. Yuan D. Dithizone staining of intracellular zinc: an unexpected and versatile counterscreen for auxotrophic marker genes in Saccharomyces cerevisiae. PLoS ONE. 2011;6:e25830 pubmed publisher
    ..Only one of 93 strains with temperature-sensitive alleles of essential genes exhibited an increase in dithizone staining at its non-permissive temperature, indicating that staining is not simply a sign of growth-arrested or ..
  71. Yu H, Song H, Chen M. Dithizone immobilized silica gel on-line preconcentration of trace copper with detection by flame atomic absorption spectrometry. Talanta. 2011;85:625-30 pubmed publisher
    A novel adsorbent-silica gel bound dithizone (H(2)Dz-SG) was prepared and used as solid-phase extraction of copper from complex matrix...
  72. Fiedor P, Oluwole S, Hardy M. Localization of endocrine pancreatic islets. World J Surg. 1996;20:1016-22; discussion 1022-3 pubmed
    ..early diagnosis of pancreatic islet rejection or for disorders of pancreatic endocrine function, we examined if dithizone (DTZ) and a synthetic iodo-derivative of DTZ (I-DTZ) can be used as a potential radioactive marker for ..
  73. Wen X, Wu P, Chen L, Hou X. Determination of cadmium in rice and water by tungsten coil electrothermal vaporization-atomic fluorescence spectrometry and tungsten coil electrothermal atomic absorption spectrometry after cloud point extraction. Anal Chim Acta. 2009;650:33-8 pubmed publisher
    ..is higher than the cloud point temperature of the selected surfactant Triton X-114, the complex of cadmium with dithizone can be quantitatively extracted into the surfactant-rich phase and subsequently separated from the bulk aqueous ..
  74. Faquim E, Munita C. Determination of copper by isotopic dilution. Biol Trace Elem Res. 1994;43-45:669-77 pubmed
    ..method was used for the determination of copper by isotopic dilution employing substoichiometric extraction with dithizone in carbon tetrachloride. The appropriate pH range for the substoichiometric extraction was 2-7...
  75. Takaishi S, Sawada M, Seno H, Kayahara T, Morita Fujisawa Y, Fukuzawa H, et al. Growth promoting effect of thioredoxin on intestinal epithelial cells. Dig Dis Sci. 2003;48:379-85 pubmed
    ..We previously showed that administration of diphenylthiocarbazone (dithizone), a zinc chelater, to rats induced the selective death of Paneth cells...
  76. Conget J, Sarri Y, Gonzalez Clemente J, Casamitjana R, Vives M, Gomis R. Deleterious effect of dithizone-DMSO staining on insulin secretion in rat and human pancreatic islets. Pancreas. 1994;9:157-60 pubmed
    b>Dithizone (DTZ) is a selective stain for pancreatic islets which facilitates their identification, being of special interest in human islet isolation assessment...
  77. Marappagounder D, Somasundaram I, Dorairaj S, Sankaran R. Differentiation of mesenchymal stem cells derived from human bone marrow and subcutaneous adipose tissue into pancreatic islet-like clusters in vitro. Cell Mol Biol Lett. 2013;18:75-88 pubmed publisher
    ..can differentiate into pancreatic islet-like clusters, as evidenced by their islet-like morphology, positive dithizone staining and expression of genes such as Nestin, PDX1, Isl 1, Ngn 3, Pax 4 and Insulin...
  78. Wen X, Deng Q, Guo J, Yang S. Ultra-sensitive determination of cadmium in rice and water by UV-vis spectrophotometry after single drop microextraction. Spectrochim Acta A Mol Biomol Spectrosc. 2011;79:508-12 pubmed publisher
    ..The influence factors relevant to SDME, such as type and volume of extractant, stirring rate and time, dithizone concentration, pH, drop volume and instrumental conditions were studied systematically...
  79. Sun D, Ji F. [Determination of activator aluminum by catalytic kinetic spectrophotometry]. Guang Pu Xue Yu Guang Pu Fen Xi. 2003;23:351-3 pubmed
    ..20 mg.L-1, the detection limit of the method was 8.2 x 10(-7) g.L-1. Combined with separation of extraction of dithizone-carbon tetrachloride solution, the method was applied to the determination of aluminum in water and tea samples ..
  80. Karaoz E, Genç Z, Demircan P, Aksoy A, Duruksu G. Protection of rat pancreatic islet function and viability by coculture with rat bone marrow-derived mesenchymal stem cells. Cell Death Dis. 2010;1:e36 pubmed publisher
  81. Seno H, Sawada M, Fukuzawa H, Morita Fujisawa Y, Takaishi S, Hiai H, et al. Involvement of tumor necrosis factor alpha in intestinal epithelial cell proliferation following Paneth cell destruction. Scand J Gastroenterol. 2002;37:154-60 pubmed
    An intravenous injection of diphenylthiocarbazone (dithizone), a zinc chelator, induces selective killing of Paneth cells which have a large amount of zinc in their cytoplasmic granules...
  82. Gorbenko N, Poltorak V, Gladkikh A, Ivanova O. [Effect of phensuccinal on lipid metabolism, lipid peroxidation, and antioxidant system activity in rabbits with dithiazone-induced diabetes]. Eksp Klin Farmakol. 2003;66:39-42 pubmed
  83. Goldberg E, Eshchenko V, Bovt V. Diabetogenic activity of chelators in some mammalian species. Endocrinologie. 1990;28:51-5 pubmed
    The investigation of diabetogenic activity of chelators (dithizone and quinoline derivatives, was carried out in 6 mammalian species (dogs, cats, rabbits, rats, golden hamsters and mice)...
  84. Wang Y, Gao S, Zang X, Li J, Ma J. Graphene-based solid-phase extraction combined with flame atomic absorption spectrometry for a sensitive determination of trace amounts of lead in environmental water and vegetable samples. Anal Chim Acta. 2012;716:112-8 pubmed publisher
    ..packed with graphene as sorbent was developed for the preconcentration of trace amounts of lead (Pb) using dithizone as chelating reagent prior to its determination by flame atomic absorption spectrometry...