diamide

Summary

Summary: A sulfhydryl reagent which oxidizes sulfhydryl groups to the disulfide form. It is a radiation-sensitizing agent of anoxic bacterial and mammalian cells.

Top Publications

  1. Rochat T, Nicolas P, Delumeau O, Rabatinov A, Korelusov J, Leduc A, et al. Genome-wide identification of genes directly regulated by the pleiotropic transcription factor Spx in Bacillus subtilis. Nucleic Acids Res. 2012;40:9571-83 pubmed publisher
    ..Three quarters of these sites were located near Sigma(A)-dependent promoters, and upon diamide treatment, the fraction of the Spx-RNAP complex increased in parallel with the number and occupancy of DNA sites...
  2. Leelakriangsak M, Huyen N, Töwe S, Van Duy N, Becher D, Hecker M, et al. Regulation of quinone detoxification by the thiol stress sensing DUF24/MarR-like repressor, YodB in Bacillus subtilis. Mol Microbiol. 2008;67:1108-24 pubmed publisher
    ..and the azoreductase encoding yvaB (azoR2) gene in response to thiol-specific stress conditions, such as diamide, catechol and 2-methylhydroquinone (MHQ)...
  3. Kallifidas D, Thomas D, Doughty P, Paget M. The sigmaR regulon of Streptomyces coelicolor A32 reveals a key role in protein quality control during disulphide stress. Microbiology. 2010;156:1661-72 pubmed publisher
    b>Diamide is an artificial disulphide-generating electrophile that mimics an oxidative shift in the cellular thiol-disulphide redox state (disulphide stress)...
  4. Tao Y, Gutteridge S, Benner E, Wu L, Rhoades D, Sacher M, et al. Identification of a critical region in the Drosophila ryanodine receptor that confers sensitivity to diamide insecticides. Insect Biochem Mol Biol. 2013;43:820-8 pubmed publisher
    ..of the Drosophila C-terminus with that from Meloidogyne results in a functional RyR which lack sensitivity to diamide insecticides...
  5. Mano J, Babiychuk E, Belles Boix E, Hiratake J, Kimura A, Inze D, et al. A novel NADPH:diamide oxidoreductase activity in arabidopsis thaliana P1 zeta-crystallin. Eur J Biochem. 2000;267:3661-71 pubmed
    ..of Arabidopsis thaliana, known to confer tolerance toward the oxidizing drug 1,1'-azobis(N, N-dimethylformamide) (diamide) to yeast [Babiychuk, E., Kushnir, S., Belles-Boix, E., Van Montagu, M. & Inzé, D. (1995) J. Biol. Chem...
  6. Nakunst D, Larisch C, Hüser A, Tauch A, Pühler A, Kalinowski J. The extracytoplasmic function-type sigma factor SigM of Corynebacterium glutamicum ATCC 13032 is involved in transcription of disulfide stress-related genes. J Bacteriol. 2007;189:4696-707 pubmed
    ..glutamicum cells more sensitive to heat, cold, and the presence of the thiol oxidant diamide. Transcription of the sigM gene increased under different stress conditions, including heat shock, cold shock, ..
  7. Kaneko T, Whittingham D, Overstreet J, Yanagimachi R. Tolerance of the mouse sperm nuclei to freeze-drying depends on their disulfide status. Biol Reprod. 2003;69:1859-62 pubmed
    ..However, immature spermatozoa became resistant to freeze-drying after their treatment with diamide, which oxidizes free -SH groups...
  8. Sun L, Cui L, Rui C, Yan X, Yang D, Yuan H. Modulation of the expression of ryanodine receptor mRNA from Plutella xylostella as a result of diamide insecticide application. Gene. 2012;511:265-73 pubmed publisher
    ..With the development of diamide insecticides that exhibit a novel mode of action on the RyRs from Lepidoptera, research on insect RyRs has become ..
  9. Yang L, Zhu X, Zhao X, Deng Z. Expression of macrophage inflammatory protein 1 alpha in the endothelial cells exposed to diamide. J Huazhong Univ Sci Technolog Med Sci. 2003;23:219-22, 233 pubmed
    In order to study whether the endothelial cells (ECs) with lipid peroxidation induced by diamide can express and secrete macrophage inflammatory protein 1 alpha (MIP-1 alpha), the expression of MIP-1 alpha protein in the cells was ..

More Information

Publications91

  1. Leichert L, Scharf C, Hecker M. Global characterization of disulfide stress in Bacillus subtilis. J Bacteriol. 2003;185:1967-75 pubmed
    ..To induce disulfide stress, we used the specific thiol oxidant diamide. After addition of 1 mM diamide to an exponentially growing culture, cell growth stopped until the medium was ..
  2. Tiwari S, Stelinski L. Effects of cyantraniliprole, a novel anthranilic diamide insecticide, against Asian citrus psyllid under laboratory and field conditions. Pest Manag Sci. 2013;69:1066-72 pubmed publisher
    ..citri has been documented. There is an urgent need to develop and integrate novel tools for the successful management of D. citri and also to prevent the development of insecticide resistance...
  3. Gu H, Iwanowicz E, Guo J, Watterson S, Shen Z, Pitts W, et al. Novel diamide-based inhibitors of IMPDH. Bioorg Med Chem Lett. 2002;12:1323-6 pubmed
    ..A series of novel amide-based small molecule inhibitors of inosine monophosphate dehydrogenase is described. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are presented...
  4. Gasch A, Spellman P, Kao C, Carmel Harel O, Eisen M, Storz G, et al. Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell. 2000;11:4241-57 pubmed
    ..temperature shocks, hydrogen peroxide, the superoxide-generating drug menadione, the sulfhydryl-oxidizing agent diamide, the disulfide-reducing agent dithiothreitol, hyper- and hypo-osmotic shock, amino acid starvation, nitrogen ..
  5. Leelakriangsak M, Kobayashi K, Zuber P. Dual negative control of spx transcription initiation from the P3 promoter by repressors PerR and YodB in Bacillus subtilis. J Bacteriol. 2007;189:1736-44 pubmed
    ..Induction of spx transcription in response to treatment with the thiol-specific oxidant diamide is the result of transcription initiation at the P(3) promoter located upstream of the spx coding sequence...
  6. Babiychuk E, Kushnir S, Belles Boix E, Van Montagu M, Inze D. Arabidopsis thaliana NADPH oxidoreductase homologs confer tolerance of yeasts toward the thiol-oxidizing drug diamide. J Biol Chem. 1995;270:26224-31 pubmed
    ..approximately 10(5) primary transformants were subjected to a tolerance screen toward the thiol-oxidizing drug diamide, which depletes the reduced glutathione in the cell. Four types of Arabidopsis cDNAs were isolated...
  7. Kim T, Kim H, Park J, Kim Y, Kim P, Lee H. Functional analysis of sigH expression in Corynebacterium glutamicum. Biochem Biophys Res Commun. 2005;331:1542-7 pubmed
    ..glutamicum cells sensitive to the thiol-specific oxidant diamide. In the sigH mutant strain, the activity of thioredoxin reductase markedly decreased, suggesting that the trxB ..
  8. Palm G, Khanh Chi B, Waack P, Gronau K, Becher D, Albrecht D, et al. Structural insights into the redox-switch mechanism of the MarR/DUF24-type regulator HypR. Nucleic Acids Res. 2012;40:4178-92 pubmed publisher
    ..encodes redox-sensing MarR-type regulators of the OhrR and DUF24-families that sense organic hydroperoxides, diamide, quinones or aldehydes via thiol-based redox-switches...
  9. LaPlante S, Gillard J, Jakalian A, Aubry N, Coulombe R, Brochu C, et al. Importance of ligand bioactive conformation in the discovery of potent indole-diamide inhibitors of the hepatitis C virus NS5B. J Am Chem Soc. 2010;132:15204-12 pubmed publisher
  10. Kim T, Liu C, Yassour M, Holik J, Friedman N, Buratowski S, et al. RNA polymerase mapping during stress responses reveals widespread nonproductive transcription in yeast. Genome Biol. 2010;11:R75 pubmed publisher
    ..However, changes in mRNA abundance reflect the combined effect of changes in RNA production, processing, and degradation, and thus, mRNA levels provide an occluded view of transcriptional regulation...
  11. Moriceau S, Lenoir G, Witko Sarsat V. In cystic fibrosis homozygotes and heterozygotes, neutrophil apoptosis is delayed and modulated by diamide or roscovitine: evidence for an innate neutrophil disturbance. J Innate Immun. 2010;2:260-6 pubmed publisher
    ..b>Diamide, a direct thiol-oxidizing agent, potentiated PMN apoptosis in controls and CF patients, resulting in similar ..
  12. Katayose H, Yanagida K, Hashimoto S, Yamada H, Sato A. Use of diamide-acridine orange fluorescence staining to detect aberrant protamination of human-ejaculated sperm nuclei. Fertil Steril. 2003;79 Suppl 1:670-6 pubmed
    ..To investigate the influence of human sperm nuclear chromatin on fertilization...
  13. Ho H, Cheng M, Shiao M, Chiu D. Characterization of global metabolic responses of glucose-6-phosphate dehydrogenase-deficient hepatoma cells to diamide-induced oxidative stress. Free Radic Biol Med. 2013;54:71-84 pubmed publisher
    ..In this study, we examined the effects of diamide on global metabolite profiles of SK-Hep1-derived SK-i-Gi and SK-i-Sc cells, which could inducibly express short ..
  14. Gao L, Cheng M, Chou H, Yang Y, Ho H, Chiu D. Ineffective GSH regeneration enhances G6PD-knockdown Hep G2 cell sensitivity to diamide-induced oxidative damage. Free Radic Biol Med. 2009;47:529-35 pubmed publisher
    ..Hep G2 cells expressing shRNA against G6PD (Gi) were more susceptible to diamide-induced cytotoxicity than control cells expressing scrambled control shRNA (Sc)...
  15. Mawatari K, Yasui S, Morizumi R, Hamamoto A, Furukawa H, Koyama K, et al. Reactive oxygen species induced by diamide inhibit insulin-induced ATP-sensitive potassium channel activation in cultured vascular smooth muscle cells. Asia Pac J Clin Nutr. 2008;17 Suppl 1:162-6 pubmed
    ..Here we examined the effects of ROS induced by a thol-oxidizing agent, diamide, on the insulin signalling pathway and KATP channel activities in cultured VSMCs (A10 cells)...
  16. Fratelli M, Demol H, Puype M, Casagrande S, Eberini I, Salmona M, et al. Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes. Proc Natl Acad Sci U S A. 2002;99:3505-10 pubmed
    ..To this purpose, we radiolabeled cellular glutathione with (35)S, exposed T cells to oxidants (diamide or hydrogen peroxide), and performed nonreducing, two-dimensional electrophoresis followed by detection of ..
  17. Streker K, Freiberg C, Labischinski H, Hacker J, Ohlsen K. Staphylococcus aureus NfrA (SA0367) is a flavin mononucleotide-dependent NADPH oxidase involved in oxidative stress response. J Bacteriol. 2005;187:2249-56 pubmed publisher
    ..Transcription was strongly induced by ethanol, diamide, and nitrofurantoin. Hydrogen peroxide induced nfrA transcription only at high concentrations...
  18. Zhang Y, Zuber P. Requirement of the zinc-binding domain of ClpX for Spx proteolysis in Bacillus subtilis and effects of disulfide stress on ClpXP activity. J Bacteriol. 2007;189:7669-80 pubmed
    ..The effect of disulfide stress on ClpXP activity was examined using the thiol-specific oxidant diamide. ClpXP-catalyzed degradation of either Spx or a green fluorescent protein derivative bearing an SsrA tag ..
  19. Pöther D, Liebeke M, Hochgräfe F, Antelmann H, Becher D, Lalk M, et al. Diamide triggers mainly S Thiolations in the cytoplasmic proteomes of Bacillus subtilis and Staphylococcus aureus. J Bacteriol. 2009;191:7520-30 pubmed publisher
    ..subtilis after treatment of cells with the disulfide-generating electrophile diamide. S cysteinylation is thought to protect protein thiols against irreversible oxidation to sulfinic and sulfonic ..
  20. Bordin L, Ion Popa F, Brunati A, Clari G, Low P. Effector-induced Syk-mediated phosphorylation in human erythrocytes. Biochim Biophys Acta. 2005;1745:20-8 pubmed
    ..tyrosine phosphorylated following treatment of intact cells with protein tyrosine phosphatase inhibitors such as diamide, pervanadate, vanadate, or N-ethylmaleimide (NEM)...
  21. Pocsi I, Miskei M, Karanyi Z, Emri T, Ayoubi P, Pusztahelyi T, et al. Comparison of gene expression signatures of diamide, H2O2 and menadione exposed Aspergillus nidulans cultures--linking genome-wide transcriptional changes to cellular physiology. BMC Genomics. 2005;6:182 pubmed
  22. Chi B, Albrecht D, Gronau K, Becher D, Hecker M, Antelmann H. The redox-sensing regulator YodB senses quinones and diamide via a thiol-disulfide switch in Bacillus subtilis. Proteomics. 2010;10:3155-64 pubmed publisher
    ..the azoreductase AzoR1, the nitroreductase YodC and the redox-sensing regulator Spx in response to quinones and diamide in Bacillus subtilis...
  23. Antelmann H, Hecker M, Zuber P. Proteomic signatures uncover thiol-specific electrophile resistance mechanisms in Bacillus subtilis. Expert Rev Proteomics. 2008;5:77-90 pubmed publisher
    ..Catechol, 2-MHQ and diamide displayed a common mode of action, as revealed by the induction of the thiol-specific oxidative stress response...
  24. Nojiri M, Uekita K, Ohnuki M, Taoka N, Yasohara Y. Microbial asymmetric hydrolysis of 3-substituted glutaric acid diamides. J Appl Microbiol. 2013;115:1127-33 pubmed publisher
    ..screened for their ability to produce (R)-3-(4-chlorophenyl) glutaric acid monoamide (CGM) from 3-(4-chlorophenyl) glutaric acid diamide (CGD) through stereoselective hydrolysis. (R)-CGM is a useful synthetic intermediate for arbaclofen.
  25. Cumpstey I, Salomonsson E, Sundin A, Leffler H, Nilsson U. Double affinity amplification of galectin-ligand interactions through arginine-arene interactions: synthetic, thermodynamic, and computational studies with aromatic diamido thiodigalactosides. Chemistry. 2008;14:4233-45 pubmed publisher
    ..Furthermore, the arginine mutants revealed distinct differences between free, flexible, and solvent-exposed arginine side chains and tightly ion-paired arginine side chains in interactions with aromatic systems. ..
  26. Wu M, Murphy P, O Doherty P, Mieruszynski S, Jones M, Kersaitis C, et al. Delineation of the molecular mechanism for disulfide stress-induced aluminium toxicity. Biometals. 2012;25:553-61 pubmed publisher
    Following our previous finding that the sulfhydryl-oxidising chemical diamide induced a marked elevation of cellular Al(3+) (Wu et al...
  27. Humphries K, Juliano C, Taylor S. Regulation of cAMP-dependent protein kinase activity by glutathionylation. J Biol Chem. 2002;277:43505-11 pubmed
    ..In vitro studies demonstrated the susceptibility of kinase activity to the sulfhydryl oxidant diamide, which inhibited by promoting an intramolecular disulfide bond between cysteines 199 and 343...
  28. Cheng C, Dong Z, Han X, Wang H, Jiang L, Sun J, et al. Thioredoxin A Is Essential for Motility and Contributes to Host Infection of Listeria monocytogenes via Redox Interactions. Front Cell Infect Microbiol. 2017;7:287 pubmed publisher
    ..monocytogenes TrxA is significantly induced in bacteria treated with the thiol-specific oxidizing agent, diamide. Deletion of trxA markedly compromised tolerance of the pathogen to diamide, and mainly impaired early ..
  29. Mariano A, Valente C, Cadena S, Rocha M, de Oliveira M, Carnieri E. Sensitivities of the alternative respiratory components of potato tuber mitochondria to thiol reagents and Ca2+. Plant Physiol Biochem. 2005;43:61-7 pubmed
    ..When the cytochrome pathway was functional, Ca(2+) stimulated the external NADH dehydrogenase. Diamide was a potent AOX inhibitor and this effect was only now observed when the cytochrome pathway was inactive, as was ..
  30. Nakao T, Banba S. Broflanilide: A meta-diamide insecticide with a novel mode of action. Bioorg Med Chem. 2016;24:372-7 pubmed publisher
    Broflanilide is a meta-diamide [3-benzamido-N-(4-(perfluoropropan-2-yl)phenyl)benzamide] that exhibits high larvicidal activity against Spodoptera litura...
  31. Montibus M, Khosravi C, Zehraoui E, Verdal Bonnin M, Richard Forget F, Barreau C. Is the Fgap1 mediated response to oxidative stress chemotype dependent in Fusarium graminearum?. FEMS Microbiol Lett. 2016;363:fnv232 pubmed publisher
    ..While the response to H2O2 was shown to be chemotype dependent, an opposite result was observed for diamide: whatever the chemotype, the global level of TCTB (i.e...
  32. Mazzei L, Cianci M, Contaldo U, Musiani F, Ciurli S. Urease Inhibition in the Presence of N-(n-Butyl)thiophosphoric Triamide, a Suicide Substrate: Structure and Kinetics. Biochemistry. 2017;56:5391-5404 pubmed publisher
    ..reveals the presence of the monoamidothiophosphoric acid (MATP) moiety, obtained upon enzymatic hydrolysis of the diamide derivative of NBPT (NBPD) to yield n-butyl amine...
  33. Li W, More S, Wang C, Jen Y, Yao C, Wang T, et al. Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents. Bioorg Med Chem Lett. 2010;20:1148-52 pubmed publisher
    This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs...
  34. Yamauchi K, Ebihara Y, Kawakami Y. Redox status of serum apolipoprotein E and its impact on HDL cholesterol levels. Clin Biochem. 2017;50:777-783 pubmed publisher
    ..001). The redox status of serum apoE might be related to the synthesis of HDL. The information concerning the redox status of serum apoE provided by the present method may be a potent indicator to evaluate various apoE-related diseases. ..
  35. Tan Z, Jia X, Ma F, Feng Y, Lu H, Jin J, et al. Increased MMAB level in mitochondria as a novel biomarker of hepatotoxicity induced by Efavirenz. PLoS ONE. 2017;12:e0188366 pubmed publisher
    ..We also detected the expression of mitochondrial precursor Cob(I)yrinic acid a,c-diamide adenosyltransferase (MMAB) by immunohistochemistry analysis in clinical samples...
  36. Hashemy S, Holmgren A. Regulation of the catalytic activity and structure of human thioredoxin 1 via oxidation and S-nitrosylation of cysteine residues. J Biol Chem. 2008;283:21890-8 pubmed publisher
    ..Human Trx1 has also three structural Cys residues in positions 62, 69, and 73 that upon diamide oxidation induce a second Cys(62)-Cys(69) disulfide as well as dimers and multimers...
  37. Rocha E, Tzianabos A, Smith C. Thioredoxin reductase is essential for thiol/disulfide redox control and oxidative stress survival of the anaerobe Bacteroides fragilis. J Bacteriol. 2007;189:8015-23 pubmed
    ..Expression of the B. fragilis trxB gene was induced following treatment with diamide or H(2)O(2) or exposure to oxygen. This inducible trxB expression was OxyR independent...
  38. Sarkar S, Roy S. Monitoring the effects of a lepidopteran insecticide, Flubendiamide, on the biology of a non-target dipteran insect, Drosophila melanogaster. Environ Monit Assess. 2017;189:557 pubmed publisher
    ..In the present study, Drosophila melanogaster is treated with sub-lethal concentrations of a diamide insecticide formulation, Flubendiamide. Chronic exposure to the diamide (0...
  39. Suzuki H, Sakabe T, Hirose Y, Eki T. Development and evaluation of yeast-based GFP and luciferase reporter assays for chemical-induced genotoxicity and oxidative damage. Appl Microbiol Biotechnol. 2017;101:659-671 pubmed publisher
    ..luc2CP reporter strain treated with tert-butyl hydroperoxide and menadione and weakly induced with diamide and diethyl maleate...
  40. Sebban M, Guillard J, Palmas P, Poullain D. Tautomerism and 1H, 13C and 15N NMR spectral assignments of some nitro derivatives of malonic acid diamide. Magn Reson Chem. 2005;43:563-6 pubmed
    Because of its reactivity, malonic acid diamide (1) was initially identified as an alternative precursor for the development of a new class of high-density insensitive energetic materials possessing low sensitivity to thermal ..
  41. McStay G, Clarke S, Halestrap A. Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore. Biochem J. 2002;367:541-8 pubmed
    Opening of the mitochondrial permeability transition pore (MPTP) is sensitized to [Ca(2+)] by oxidative stress (diamide) and phenylarsine oxide (PAO)...
  42. Kocabas E, Durmaz M, Alpaydin S, Sirit A, Yilmaz M. Chiral mono and diamide derivatives of calix[4]arene for enantiomeric recognition of chiral amines. Chirality. 2008;20:26-34 pubmed
    Novel chiral mono and diamide derivatives of calix[4]arene have been prepared from the aminolysis reaction of 5,11,17,23-tetra-tert-butyl-25,27-diethoxycarbonyl-methoxy-26,28-dihydroxycalix[4]arene 1 and 25,27-diethoxycarbonyl-methoxy-26,..
  43. Chalmers K, Botta M, Parker D. Strategies to enhance signal intensity with paramagnetic fluorine-labelled lanthanide complexes as probes for 19F magnetic resonance. Dalton Trans. 2011;40:904-13 pubmed publisher
    ..properties are reported for three series of CF(3)-labelled lanthanide(III) complexes, based on mono- and diamide cyclen ligands...
  44. Jeanguenat A, Durieux P, Edmunds A, Hall R, Hughes D, Loiseleur O, et al. Bicyclic heterocyclic anthranilic diamides as ryanodine receptor modulators with insecticidal activity. Bioorg Med Chem. 2016;24:403-27 pubmed publisher
    The diamide insecticides act on the ryanodine receptor (RyR). The synthesis of various bicyclic anthranilic derivatives is reported...
  45. Huang T, Vanden Eynde J, Mayence A, Collins M, Cushion M, Rattendi D, et al. Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity. Bioorg Med Chem Lett. 2009;19:5884-6 pubmed publisher
    ..carinii, and was non-cytotoxic in the A549 human lung carcinoma cell line. The inhibitory bioactivity was significantly reduced when the amidine groups in 4 were moved from the para to the meta positions or replaced with amides. ..
  46. Hartman M, Figueroa C, Arias D, Iglesias A. Inhibition of Recombinant Aldose-6-Phosphate Reductase from Peach Leaves by Hexose-Phosphates, Inorganic Phosphate and Oxidants. Plant Cell Physiol. 2017;58:145-155 pubmed publisher
    ..Enzyme thiolation with oxidized glutathione protected the enzyme from insolubilization caused by diamide, while incubation with NADP+ (one of the substrates) completely prevented enzyme precipitation...
  47. Sarkar S, Khatun S, Dutta M, Roy S. Trans-generational transmission of altered phenotype resulting from flubendiamide-induced changes in apoptosis in larval imaginal discs of Drosophila melanogaster. Environ Toxicol Pharmacol. 2017;56:350-360 pubmed publisher
    ..Thus, the diamide insecticide, flubendiamide, expected to be environmentally safe at sub-lethal concentrations was found to ..
  48. Bisaccia F, Zara V, Capobianco L, Iacobazzi V, Mazzeo M, Palmieri F. The formation of a disulfide cross-link between the two subunits demonstrates the dimeric structure of the mitochondrial oxoglutarate carrier. Biochim Biophys Acta. 1996;1292:281-88 pubmed
    ..carrier (OGC) can be cross-linked to dimers by disulfide-forming reagents such as Cu2+-phenanthroline and diamide. Acetone and other solvents increase the extent of Cu2+ -phenanthroline-induced cross-linking of OGC...
  49. Hansen R, Roth D, Winther J. Quantifying the global cellular thiol-disulfide status. Proc Natl Acad Sci U S A. 2009;106:422-7 pubmed publisher
    ..However, when cells are exposed to a sublethal dose of the thiol-specific oxidant diamide, PSSG levels increase to >15% of all protein cysteine...
  50. Cui L, Rui C, Yang D, Wang Z, Yuan H. De novo transcriptome and expression profile analyses of the Asian corn borer (Ostrinia furnacalis) reveals relevant flubendiamide response genes. BMC Genomics. 2017;18:20 pubmed publisher
    ..The differentially expressed gene data will elucidate the molecular mechanisms of ACB in response to the novel diamide insecticide, flubendiamide...
  51. Sahai M, Kehoe T, Koo J, Setiadi D, Chass G, Viskolcz B, et al. First principle computational study on the full conformational space of L-proline diamides. J Phys Chem A. 2005;109:2660-79 pubmed
  52. Petronilli V, Costantini P, Scorrano L, Colonna R, Passamonti S, Bernardi P. The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents. J Biol Chem. 1994;269:16638-42 pubmed
    ..We have investigated the mechanism by which the pore is induced by menadione, diamide, arsenite, and tert-butylhydroperoxide...
  53. Wu Y, Chen X, Gier L, Almarsson O, Ostovic D, Loper A. Identification of oxidative degradates of the thrombin inhibitor, 3-(2-phenethylamino)-6-methyl-1-(2-amino-6-methyl-5-methyleneca rboxamidomethylpyridinyl)pyrazinone, using liquid chromatography/mass spectrometry and liquid chromatography/tandem mass. J Pharm Biomed Anal. 1999;20:471-85 pubmed
    ..The structural assignments for these two products were alpha-amidinoamide and alpha-diamide compounds, respectively...
  54. Ergun Y, Ogulener N. Selective modifiers of glutathione prevent restoration of photorelaxations in mouse gastric fundus. Fundam Clin Pharmacol. 2005;19:503-9 pubmed
    ..Ethacrynic acid (1 microm), diamide (1 microm) and glutathione (1 microm) had no effect on the photorelaxations occurred in the second series of ..
  55. Donà V, Rodrigue S, Dainese E, Palu G, Gaudreau L, Manganelli R, et al. Evidence of complex transcriptional, translational, and posttranslational regulation of the extracytoplasmic function sigma factor sigmaE in Mycobacterium tuberculosis. J Bacteriol. 2008;190:5963-71 pubmed publisher
    ..Taken together, our data demonstrate that sigma(E) not only is subjected to complex transcriptional regulation but is also controlled at the translational and posttranslational levels...
  56. Ahuja G, Mathur P. Fe (III) complexes of a bis-benzimidazolyl diamide ligand: spectral and catalytic studies. Spectrochim Acta A Mol Biomol Spectrosc. 2011;83:180-6 pubmed publisher
    A new tetradentate bis benzimidaozlyl diamide ligand N,N'-Bis (benzimidazol-2-yl-methyl)-hexane-1,6-dicarboxamide (GBSA) has been synthesized and utilized to prepare new Fe(III) complexes with exogenous anionic ligand X=Cl(-) and NO(3)(-)..
  57. Kim J, Livinghouse T. Chelating diamide based rate enhancement of intramolecular alkene hydroaminations catalyzed by a neutral Sc(III) complex. Org Lett. 2005;7:4391-3 pubmed
    ..activity is strongly coupled to the electronic character of the Sc(III) ligand environment with chelating diamide coordination providing a precatalyst possessing substantially improved activity and superb distereoselectivity in ..
  58. Demir A, Koc A. Assessment of chronological lifespan dependent molecular damages in yeast lacking mitochondrial antioxidant genes. Biochem Biophys Res Commun. 2010;400:106-10 pubmed publisher
    ..Among these mutants, ccp1?, trx3?, grx5?, prx1?, mutants were sensitive to diamide, and ccs1? and sod2? were sensitive to both diamide and menadione...
  59. Li Y, Zhu H, Chen K, Liu R, Khallaf A, Zhang X, et al. Synthesis, insecticidal activity, and structure-activity relationship (SAR) of anthranilic diamides analogs containing oxadiazole rings. Org Biomol Chem. 2013;11:3979-88 pubmed publisher
    ..This work provides some hints for further structure modification and the enhancement of insecticidal activity...
  60. Carroll J, Raththagala M, Subasinghe W, Baguzis S, D amico Oblak T, Root P, et al. An altered oxidant defense system in red blood cells affects their ability to release nitric oxide-stimulating ATP. Mol Biosyst. 2006;2:305-11 pubmed
    ..These data suggest that the antioxidant status of erythrocytes is a critical determinant in the ability of these cells to release ATP, a known nitric oxide stimulus...
  61. Chen Y, Cherry K, Corman M, Ebbinghaus C, Gamlath C, Liston D, et al. Thiazole-diamides as potent gamma-secretase inhibitors. Bioorg Med Chem Lett. 2007;17:5518-22 pubmed
    The thiazole-diamide series (1) has been identified as highly potent gamma-secretase inhibitors. Several representative compounds showed IC(50) values of <0.3 nM...
  62. Jarmuszkiewicz W, Wagner A, Wagner M, Hryniewiecka L. Immunological identification of the alternative oxidase of Acanthamoeba castellanii mitochondria. FEBS Lett. 1997;411:110-4 pubmed
    ..Immunologically detectable protein levels change with the age of amoeba cell culture. Increased amounts of the 35 kDa protein are accompanied by an increase in the activity of cyanide-resistant respiration...
  63. Di Simplicio P, Cacace M, Lusini L, Giannerini F, Giustarini D, Rossi R. Role of protein -SH groups in redox homeostasis--the erythrocyte as a model system. Arch Biochem Biophys. 1998;355:145-52 pubmed
    ..Blood samples of the four species were also treated with 0.5-1.5 mM tert-butyl hydroperoxide (t-BOOH) or diamide, and levels of glutathione-derived species [GSH, GSSG, and glutathione-protein mixed disulfides (GS-SP)] were ..
  64. Li X, Degain B, Harpold V, Marçon P, Nichols R, Fournier A, et al. Baseline susceptibilities of B- and Q-biotype Bemisia tabaci to anthranilic diamides in Arizona. Pest Manag Sci. 2012;68:83-91 pubmed publisher
  65. Allan L, Clarkson G, Fox D, Gott A, Scott P. Mechanism of catalytic cyclohydroamination by zirconium salicyloxazoline complexes. J Am Chem Soc. 2010;132:15308-20 pubmed publisher
    ..The fate of the catalyst in the absence of excess amine (at the end of the catalytic reaction) is conversion to a metallacyclic species arising from CH activation of a peripheral substituent...
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    ..by testing cells in solution of different osmolarities (239-392 mosmol I(-1)), and cells at different stages of diamide treatment (0.5-5.0 mmol I(-1)). The calculated membrane bending modulus of 1...
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    The mechanism of increase in the inner membrane permeability induced by Ca2+ plus Pi, diamide and hydroperoxides has been analyzed. (1) The permeability increase is antagonized by oligomycin and favoured by atractyloside...
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