azoxymethane

Summary

Summary: A potent carcinogen and neurotoxic compound. It is particularly effective in inducing colon carcinomas.

Top Publications

  1. Velmurugan B, Singh R, Agarwal R, Agarwal C. Dietary-feeding of grape seed extract prevents azoxymethane-induced colonic aberrant crypt foci formation in fischer 344 rats. Mol Carcinog. 2010;49:641-52 pubmed publisher
    ..This study assessed dietary grape seed extract (GSE) effectiveness in preventing azoxymethane (AOM)-induced aberrant crypt foci (ACF) formation and associated mechanisms in Fischer 344 rats...
  2. Meunier C, Cai J, Fortin A, Kwan T, Marquis J, Turbide C, et al. Characterization of a major colon cancer susceptibility locus (Ccs3) on mouse chromosome 3. Oncogene. 2010;29:647-61 pubmed publisher
    Treatment of mice with the carcinogen azoxymethane (AOM) induces a number of lesions in the colon, including hyperplastic lesions, as well adenomas and carcinomas in situ...
  3. Ju J, Hao X, Lee M, Lambert J, Lu G, Xiao H, et al. A gamma-tocopherol-rich mixture of tocopherols inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sulfate sodium-treated mice. Cancer Prev Res (Phila). 2009;2:143-52 pubmed publisher
    ..of tocopherols (gamma-TmT, containing 57% gamma-T, 24% delta-T, and 13% alpha-T) on colon carcinogenesis in azoxymethane (AOM)/dextran sulfate sodium (DSS)-treated mice...
  4. Raju J. Azoxymethane-induced rat aberrant crypt foci: relevance in studying chemoprevention of colon cancer. World J Gastroenterol. 2008;14:6632-5 pubmed
    ..For over two decades, since its first discovery, azoxymethane (AOM)-induced rodent ACF have served as surrogate biomarkers in the screening of various anticarcinogens and ..
  5. Kim H, Kundu J, Lee J, Oh T, Na H, Surh Y. Chemopreventive effects of the standardized extract (DA-9601) of Artemisia asiatica on azoxymethane-initiated and dextran sulfate sodium-promoted mouse colon carcinogenesis. Nutr Cancer. 2008;60 Suppl 1:90-7 pubmed publisher
    ..When male ICR mice were treated with a single intraperitoneal dose (10 mg/kg body weight) of azoxymethane (AOM) followed by 2...
  6. Fichera A, Little N, Jagadeeswaran S, Dougherty U, Sehdev A, Mustafi R, et al. Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis. Cancer Res. 2007;67:827-35 pubmed
    ..the current study, we used a specific EGFR antagonist, gefitinib, to investigate this role of the receptor in azoxymethane colonic premalignancy...
  7. Paulsen J, Knutsen H, Ølstørn H, Løberg E, Alexander J. Identification of flat dysplastic aberrant crypt foci in the colon of azoxymethane-treated A/J mice. Int J Cancer. 2006;118:540-6 pubmed
    ..In Min/+ mice and their wild-type littermates treated with azoxymethane (AOM), we previously identified a subgroup of flat ACF that seem more immediate precursors of tumors than the ..
  8. Ghafar S, Yazan L, Tahir P, Ismail M. Kenaf seed supercritical fluid extract reduces aberrant crypt foci formation in azoxymethane-induced rats. Exp Toxicol Pathol. 2012;64:247-51 pubmed publisher
    ..goal, 60 male rats were randomly assigned to 5 groups which were (1) negative control group [not induced with azoxymethane (AOM)]; (2) positive control group (induced with AOM but received no treatment); (3) group treated with 500 mg/..
  9. Lu Q, Jiang B, Lin C, Shan T. Dark Aberrant Crypt Foci with activated Wnt pathway are related to tumorigenesis in the colon of AOM-treated rat. J Exp Clin Cancer Res. 2008;27:26 pubmed publisher
    ..Crypt Foci (ACF) and tumorigenesis, we observed the sequential development from ACF to tumor in the colon of azoxymethane-exposed wistar rats...

More Information

Publications93

  1. Miyoshi N, Nagasawa T, Mabuchi R, Yasui Y, Wakabayashi K, Tanaka T, et al. Chemoprevention of azoxymethane/dextran sodium sulfate-induced mouse colon carcinogenesis by freeze-dried yam sanyaku and its constituent diosgenin. Cancer Prev Res (Phila). 2011;4:924-34 pubmed publisher
    ..Male ICR mice were subjected to a single intraperitoneal injection of azoxymethane (AOM; 10 mg/kg body weight) followed by administration of 1...
  2. Le Leu R, Brown I, Hu Y, Esterman A, Young G. Suppression of azoxymethane-induced colon cancer development in rats by dietary resistant starch. Cancer Biol Ther. 2007;6:1621-6 pubmed
    ..the hypothesis that feeding dietary resistant starch (as high amylose maize starch) would protect against azoxymethane (AOM)-colon carcinogenesis and favourably influence the colonic luminal environment...
  3. Suh N, Paul S, Hao X, Simi B, Xiao H, Rimando A, et al. Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats. Clin Cancer Res. 2007;13:350-5 pubmed
    ..Experiments were designed to study the inhibitory effect of pterostilbene against the formation of azoxymethane-induced colonic aberrant crypt foci (ACF) preneoplastic lesions in male F344 rats...
  4. Lai C, Li S, Liu C, Miyauchi Y, Suzawa M, Ho C, et al. Effective suppression of azoxymethane-induced aberrant crypt foci formation in mice with citrus peel flavonoids. Mol Nutr Food Res. 2013;57:551-5 pubmed publisher
    ..investigation of inhibitory effects of a formulated product from citrus peel extract, gold lotion (GL), on azoxymethane-induced colonic tumorigenesis...
  5. Ealey K, Archer M. Elevated circulating adiponectin and elevated insulin sensitivity in adiponectin transgenic mice are not associated with reduced susceptibility to colon carcinogenesis. Int J Cancer. 2009;124:2226-30 pubmed publisher
    ..old male and female AdTg and WT mice were treated with 4 weekly injections of the colon-specific carcinogen azoxymethane (AOM)...
  6. Ashokkumar P, Sudhandiran G. Luteolin inhibits cell proliferation during Azoxymethane-induced experimental colon carcinogenesis via Wnt/ ?-catenin pathway. Invest New Drugs. 2011;29:273-84 pubmed publisher
    The protective role of Luteolin (LUT) against Azoxymethane (AOM)-induced mouse colon carcinogenesis has been documented earlier...
  7. Perse M, Cerar A. Morphological and molecular alterations in 1,2 dimethylhydrazine and azoxymethane induced colon carcinogenesis in rats. J Biomed Biotechnol. 2011;2011:473964 pubmed publisher
    The dimethyhydrazine (DMH) or azoxymethane (AOM) model is a well-established, well-appreciated, and widely used model of experimental colon carcinogenesis...
  8. Shitashige M, Satow R, Honda K, Ono M, Hirohashi S, Yamada T. Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis. Cancer Sci. 2007;98:1862-7 pubmed
    ..5, whereas heterozygous (Sf1(+/-)) mice were born alive and developed normally. Azoxymethane (AOM) was given at a dose of 10 mg/kg body weight once a week for 6 weeks to 7-week-old Sf1(+/-) and Sf1(+/+) ..
  9. McIntosh G, Royle P, Lesno S, Scherer B. Selenised casein protects against AOM-induced colon tumors in Sprague Dawley rats. Nutr Cancer. 2006;54:209-15 pubmed
    ..Se as selenised yeast (Sel-Plex) Their influence on colon tumor expression was examined in rats induced with azoxymethane, the diets being introduced post-induction...
  10. Alain T, Wong J, Endersby R, Urbanski S, Lee P, Muruve D, et al. Reovirus decreases azoxymethane-induced aberrant crypt foci and colon cancer in a rodent model. Cancer Gene Ther. 2007;14:867-72 pubmed
    ..the effectiveness of reovirus against aberrant crypt foci (ACF) and colon cancer induced by the carcinogen azoxymethane (AOM) in an immunocompetent rat model...
  11. Chen J, Huang X. The signal pathways in azoxymethane-induced colon cancer and preventive implications. Cancer Biol Ther. 2009;8:1313-7 pubmed
    ..Thus, it is necessary to further understand its biology and search for effective therapy. Azoxymethane (AOM) is a common model for colon cancer...
  12. Kohno H, Suzuki R, Sugie S, Tanaka T. Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate. Cancer Sci. 2005;96:69-76 pubmed
    ..previous study, we developed a novel mouse model for colitis-related carcinogenesis, utilizing a single dose of azoxymethane (AOM) followed by dextran sodium sulfate (DSS) in drinking water...
  13. Jacobsen H, Poulsen M, Dragsted L, Ravn Haren G, Meyer O, Lindecrona R. Carbohydrate digestibility predicts colon carcinogenesis in azoxymethane-treated rats. Nutr Cancer. 2006;55:163-70 pubmed
    The purpose of this study was to compare the effect of carbohydrate structure and digestibility on azoxymethane (AOM)-induced colon carcinogenesis...
  14. Watanabe H, Kashimoto N, Ushijima M, Tamura K. Effects of a water-soluble extract of Ganoderma lucidum mycelia on aberrant crypt foci induced by azoxymethane and small-intestinal injury by 5-FU in F344 rats. Med Mol Morphol. 2013;46:97-103 pubmed publisher
    ..Mannentake) (designated as MAK) exerted a protective effect against induction of aberrant crypt foci (ACF) by azoxymethane (AOM) and small-intestinal damage induced by the anticancer drug 5-FU...
  15. Ishikawa T, Herschman H. Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expression. Carcinogenesis. 2010;31:729-36 pubmed publisher
    ..mice to a well-known mouse model of colitis-associated cancer in which animals are treated with a single-azoxymethane (AOM) injection followed by dextran sulfate sodium (DSS) administration...
  16. Teraoka N, Mutoh M, Takasu S, Ueno T, Nakano K, Takahashi M, et al. High susceptibility to azoxymethane-induced colorectal carcinogenesis in obese KK-Ay mice. Int J Cancer. 2011;129:528-35 pubmed publisher
    ..Treatment with azoxymethane (AOM; 200 ?g/mouse injected once a week for 3 times) resulted in markedly increased colon aberrant crypt foci (..
  17. Bobe G, Barrett K, Mentor Marcel R, Saffiotti U, Young M, Colburn N, et al. Dietary cooked navy beans and their fractions attenuate colon carcinogenesis in azoxymethane-induced ob/ob mice. Nutr Cancer. 2008;60:373-81 pubmed publisher
    ..6% fat including 12.9% lard) as control diet were fed to 160 male obese ob/ob mice after 2 azoxymethane injections...
  18. Clapper M, Gary M, Coudry R, Litwin S, Chang W, Devarajan K, et al. 5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis. Inflamm Bowel Dis. 2008;14:1341-7 pubmed publisher
    ..The chemopreventive activity of 5-ASA was evaluated in the Swiss Webster model of azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colitis-associated neoplasia. Mice were injected with AOM (7...
  19. Shaker A, Swietlicki E, Wang L, Jiang S, Onal B, Bala S, et al. Epimorphin deletion protects mice from inflammation-induced colon carcinogenesis and alters stem cell niche myofibroblast secretion. J Clin Invest. 2010;120:2081-93 pubmed publisher
    ..examining the effects of epimorphin deletion on chronic inflammation-associated colon carcinogenesis using the azoxymethane/dextran sodium sulfate (AOM/DSS) model...
  20. Bemeur C, Qu H, Desjardins P, Butterworth R. IL-1 or TNF receptor gene deletion delays onset of encephalopathy and attenuates brain edema in experimental acute liver failure. Neurochem Int. 2010;56:213-5 pubmed publisher
    ..IFN-gamma) mRNAs were measured in the brains of mice with acute liver failure resulting from exposure to azoxymethane. In addition, time to severe encephalopathy (coma) was assessed in mice lacking genes coding for interferon-..
  21. Bemeur C, Vaquero J, Desjardins P, Butterworth R. N-acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms. Metab Brain Dis. 2010;25:241-9 pubmed publisher
    ..of encephalopathy, cerebral edema, and plasma proinflammatory cytokines in mice with ALF resulting from azoxymethane (AOM) hepatotoxicity, a well characterized model of toxic liver injury...
  22. Xiao H, Hao X, Simi B, Ju J, Jiang H, Reddy B, et al. Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats. Carcinogenesis. 2008;29:113-9 pubmed
    ..of colon carcinogenesis, we conducted a study with green tea polyphenols as the preventive agent in an azoxymethane (AOM)-induced rat colon cancer model using aberrant crypt foci (ACF) as an end point...
  23. Yasui Y, Suzuki R, Kohno H, Miyamoto S, Beppu F, Hosokawa M, et al. 9trans,11trans conjugated linoleic acid inhibits the development of azoxymethane-induced colonic aberrant crypt foci in rats. Nutr Cancer. 2007;59:82-91 pubmed
    We investigated the effects of 9trans,11trans (9t,11t)-conjugated linoleic acid (CLA) isomer on azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) in rats...
  24. Shiozaki K, Yamaguchi K, Sato I, Miyagi T. Plasma membrane-associated sialidase (NEU3) promotes formation of colonic aberrant crypt foci in azoxymethane-treated transgenic mice. Cancer Sci. 2009;100:588-94 pubmed publisher
    ..we examined the susceptibility of NEU3 transgenic mice to induction of colonic aberrant crypt foci (ACF) by azoxymethane. Mice were injected with azoxymethane (i.p...
  25. Pierre F, Santarelli R, Allam O, Tache S, Naud N, Gueraud F, et al. Freeze-dried ham promotes azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colon. Nutr Cancer. 2010;62:567-73 pubmed publisher
    ..Freeze-dried cooked ham can promote colon carcinogenesis in a rodent model. Hemin, but not hemoglobin, mimicked ham effect on early biochemical markers associated with carcinogenesis. ..
  26. Volate S, Muga S, Issa A, Nitcheva D, Smith T, Wargovich M. Epigenetic modulation of the retinoid X receptor alpha by green tea in the azoxymethane-Apc Min/+ mouse model of intestinal cancer. Mol Carcinog. 2009;48:920-33 pubmed publisher
    We investigated the possible mechanisms of inhibition of colorectal carcinogenesis by green tea (GT) in azoxymethane-treated (AOM) Apc(Min/+) mice. Mice received water or a 0.6% (w/v) solution of GT as the only source of beverage...
  27. Cheung K, Khor T, Huang M, Kong A. Differential in vivo mechanism of chemoprevention of tumor formation in azoxymethane/dextran sodium sulfate mice by PEITC and DBM. Carcinogenesis. 2010;31:880-5 pubmed publisher
    ..In this study, we investigated the chemopreventive efficacy of PEITC and DBM in the azoxymethane (AOM)-initiated and dextran sodium sulfate (DSS)-promoted colon cancer mouse model and to compare their ..
  28. Xiao R, Su Y, Simmen R, Simmen F. Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase. Am J Physiol Gastrointest Liver Physiol. 2008;294:G868-76 pubmed publisher
    ..SPI), compared with a control casein diet, in male Sprague-Dawley rats administered the colon carcinogen azoxymethane. SPI consumption resulted in decreased serum insulin levels and decreased azoxymethane-induced tumor suppressor ..
  29. Nagamine C, Rogers A, Fox J, Schauer D. Helicobacter hepaticus promotes azoxymethane-initiated colon tumorigenesis in BALB/c-IL10-deficient mice. Int J Cancer. 2008;122:832-8 pubmed
    ..We tested the hypotheses that (i) azoxymethane (AOM), a carcinogen that targets the colon, synergizes with the colonic inflammation inherent in the BALB/c-..
  30. Khurana S, Shah N, Cheng K, Shiu B, Samimi R, Belo A, et al. Scopolamine treatment and muscarinic receptor subtype-3 gene ablation augment azoxymethane-induced murine liver injury. J Pharmacol Exp Ther. 2010;333:639-49 pubmed publisher
    ..antagonist, and specific genetic ablation of a key cholinergic receptor, muscarinic subtype-3 (Chrm3), on azoxymethane (AOM)-induced liver injury in mice...
  31. Yasuda Y, Shimizu M, Shirakami Y, Sakai H, Kubota M, Hata K, et al. Pitavastatin inhibits azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice. Cancer Sci. 2010;101:1701-7 pubmed publisher
    ..study examined the effects of pitavastatin, a recently developed lipophilic statin, on the development of azoxymethane (AOM)-initiated colonic premalignant lesions in C57BL/KsJ-db/db (db/db) obese mice...
  32. Rao C, Reddy B, Steele V, Wang C, Liu X, Ouyang N, et al. Nitric oxide-releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets. Mol Cancer Ther. 2006;5:1530-8 pubmed
    ..We assessed the chemopreventive properties of NO-indomethacin (NCX 530) and NO-aspirin (NCX 4016) against azoxymethane-induced colon cancer...
  33. Mentor Marcel R, Bobe G, Barrett K, Young M, Albert P, Bennink M, et al. Inflammation-associated serum and colon markers as indicators of dietary attenuation of colon carcinogenesis in ob/ob mice. Cancer Prev Res (Phila). 2009;2:60-9 pubmed publisher
    ..ob/ob mice (n = 160) were injected with the carcinogen azoxymethane (AOM) to induce colon cancer and randomly placed on one of four diets (control, whole navy bean, bean residue ..
  34. Gierut J, Zheng Y, Bie W, Carroll R, Ball Kell S, Haegebarth A, et al. Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane. Gastroenterology. 2011;141:1371-80, 1380.e1-2 pubmed publisher
    ..Signal transducer and activator of transcription 3 (STAT3) mediates pathogenesis of colon cancer and is a substrate of PTK6. We investigated the role of PTK6 in colon tumorigenesis...
  35. Dougherty U, Sehdev A, Cerda S, Mustafi R, Little N, Yuan W, et al. Epidermal growth factor receptor controls flat dysplastic aberrant crypt foci development and colon cancer progression in the rat azoxymethane model. Clin Cancer Res. 2008;14:2253-62 pubmed publisher
    ..The azoxymethane model of colon cancer recapitulates many aspects of human colonic tumors...
  36. Ogawa K, Hara T, Shimizu M, Ninomiya S, Nagano J, Sakai H, et al. Suppression of azoxymethane-induced colonic preneoplastic lesions in rats by 1-methyltryptophan, an inhibitor of indoleamine 2,3-dioxygenase. Cancer Sci. 2012;103:951-8 pubmed publisher
    ..IDO inhibitor, and (-)-epigallocatechin gallate (EGCG), the major catechin in green tea, on the development of azoxymethane (AOM)-induced colonic preneoplastic lesions by focusing on the inhibition of IDO...
  37. Macleod R. Extracellular calcium-sensing receptor/PTH knockout mice colons have increased Wnt/?-catenin signaling, reduced non-canonical Wnt signaling, and increased susceptibility to azoxymethane-induced aberrant crypt foci. Lab Invest. 2013;93:520-7 pubmed publisher
    ..calcium-mediated chemoprevention of colon cancer, we induced formation of aberrant crypt foci (ACF) caused by azoxymethane (AOM) injection in 'rescued' CaSR-/PTH- (C-/P-) double knockout colons compared with colons from control CaSR+/..
  38. Al Johar D, Shinwari N, Arif J, Al Sanea N, Jabbar A, El Sayed R, et al. Role of Nigella sativa and a number of its antioxidant constituents towards azoxymethane-induced genotoxic effects and colon cancer in rats. Phytother Res. 2008;22:1311-23 pubmed publisher
    ..sativa and some of its antioxidant constituents on a number of colon cancer biomarkers in rats induced with azoxymethane (AOM)...
  39. Wu B, Ootani A, Iwakiri R, Sakata Y, Fujise T, Amemori S, et al. T cell deficiency leads to liver carcinogenesis in azoxymethane-treated rats. Exp Biol Med (Maywood). 2006;231:91-8 pubmed
    ..Athymic F344/N Jcl-rnu/- (nu/nu) rats and euthymic F344/N Jcl-rnu/+(nu/+) rats were administered the carcinogen azoxymethane (AOM) at a dose of 15 mg/kg body wt once a week for 2 weeks...
  40. Reddy B, Wang C, Kong A, Khor T, Zheng X, Steele V, et al. Prevention of azoxymethane-induced colon cancer by combination of low doses of atorvastatin, aspirin, and celecoxib in F 344 rats. Cancer Res. 2006;66:4542-6 pubmed
    ..celecoxib, and aspirin, given individually at high dose levels and in combination at lower doses against azoxymethane-induced colon carcinogenesis, in male F 344 rats...
  41. Zhang Y, Li Q, Zhou D, Chen H. Genistein, a soya isoflavone, prevents azoxymethane-induced up-regulation of WNT/?-catenin signalling and reduces colon pre-neoplasia in rats. Br J Nutr. 2013;109:33-42 pubmed publisher
    ..Specifically, the effects on the WNT/?-catenin signalling pathway from GEN were examined by using an azoxymethane (AOM)-induced rat colon cancer model...
  42. Kwon Y, Magnuson B. Aging alters acute apoptotic response to azoxymethane in the colon of rats. Exp Gerontol. 2007;42:1154-61 pubmed
    ..We induced colonic apoptosis using azoxymethane (AOM) in three different aged (6 week, 12 month, and 22 month) F344 rats and assessed age-related differences ..
  43. Saiprasad G, Chitra P, Manikandan R, Sudhandiran G. Hesperidin alleviates oxidative stress and downregulates the expressions of proliferative and inflammatory markers in azoxymethane-induced experimental colon carcinogenesis in mice. Inflamm Res. 2013;62:425-40 pubmed publisher
    ..The present study was intended to elucidate the chemopreventive efficacy of hesperidin against azoxymethane (AOM)-induced mouse colon carcinogenesis.
  44. Davidson L, Wang N, Shah M, Lupton J, Ivanov I, Chapkin R. n-3 Polyunsaturated fatty acids modulate carcinogen-directed non-coding microRNA signatures in rat colon. Carcinogenesis. 2009;30:2077-84 pubmed publisher
    ..Sprague-Dawley rats were fed diets containing corn oil or fish oil with pectin or cellulose and injected with azoxymethane (AOM, a colon-specific carcinogen) or saline (control)...
  45. Paul S, DeCastro A, Lee H, Smolarek A, So J, Simi B, et al. Dietary intake of pterostilbene, a constituent of blueberries, inhibits the beta-catenin/p65 downstream signaling pathway and colon carcinogenesis in rats. Carcinogenesis. 2010;31:1272-8 pubmed publisher
    ..in reducing the incidence and multiplicity of aberrant crypt foci formation in the colon of rats injected with azoxymethane (AOM)...
  46. Suzuki R, Miyamoto S, Yasui Y, Sugie S, Tanaka T. Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate. BMC Cancer. 2007;7:84 pubmed
  47. Vergara Castañeda H, Guevara González R, Ramos Gomez M, Reynoso Camacho R, Guzmán Maldonado H, Feregrino Pérez A, et al. Non-digestible fraction of cooked bean (Phaseolus vulgaris L.) cultivar Bayo Madero suppresses colonic aberrant crypt foci in azoxymethane-induced rats. Food Funct. 2010;1:294-300 pubmed publisher
    ..cultivar Bayo Madero was evaluated for its chemopreventive effect on azoxymethane (AOM) induced aberrant crypt foci (ACF) in rats...
  48. Ravichandran K, Velmurugan B, Gu M, Singh R, Agarwal R. Inhibitory effect of silibinin against azoxymethane-induced colon tumorigenesis in A/J mice. Clin Cancer Res. 2010;16:4595-606 pubmed publisher
    ..Herein, for the first time, we investigate in vivo the efficacy of silibinin against azoxymethane-induced colon tumorigenesis in A/J mice.
  49. Puangpraphant S, Dia V, de Mejia E, Garcia G, Berhow M, Wallig M. Yerba mate tea and mate saponins prevented azoxymethane-induced inflammation of rat colon through suppression of NF-?B p65ser(311) signaling via I?B-? and GSK-3? reduced phosphorylation. Biofactors. 2013;39:430-40 pubmed publisher
    ..The objective was to determine the capability of YMT and mate saponins to prevent azoxymethane (AOM)-induced colonic inflammation in rats...
  50. Martin J, Le Leu R, Hu Y, Young G. R-flurbiprofen suppresses distal nonmucin-producing colorectal tumors in azoxymethane-treated rats, without suppressing eicosanoid production. Am J Physiol Gastrointest Liver Physiol. 2010;298:G860-4 pubmed publisher
    ..Using the azoxymethane (AOM)-rat model of carcinogenesis, we aimed to test the potency of a low-toxicity R-flurbiprofen and whether ..
  51. Hayashi K, Suzuki R, Miyamoto S, Shin Ichiroh Y, Kohno H, Sugie S, et al. Citrus auraptene suppresses azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db mice. Nutr Cancer. 2007;58:75-84 pubmed
    ..current study was designed to investigate whether dietary citrus auraptene (AUR) suppresses the development of azoxymethane (AOM)-induced colorectal preneoplastic lesions in C57BL/KsJ-db/db (db/db) mice with obese and diabetic ..
  52. Dougherty U, Cerasi D, Taylor I, Kocherginsky M, Tekin U, Badal S, et al. Epidermal growth factor receptor is required for colonic tumor promotion by dietary fat in the azoxymethane/dextran sulfate sodium model: roles of transforming growth factor-{alpha} and PTGS2. Clin Cancer Res. 2009;15:6780-9 pubmed publisher
    ..Western-style diets promote development of azoxymethane-induced colon cancer...
  53. Roy H, Karolski W, Wali R, Ratashak A, Hart J, Smyrk T. The nonsteroidal anti-inflammatory drug, nabumetone, differentially inhibits beta-catenin signaling in the MIN mouse and azoxymethane-treated rat models of colon carcinogenesis. Cancer Lett. 2005;217:161-9 pubmed
    ..However, in the azoxymethane-treated rat, where beta-catenin is frequently rendered GSK-3beta-insensitive, nabumetone failed to alter beta-..
  54. Janakiram N, Steele V, Rao C. Estrogen receptor-beta as a potential target for colon cancer prevention: chemoprevention of azoxymethane-induced colon carcinogenesis by raloxifene in F344 rats. Cancer Prev Res (Phila). 2009;2:52-9 pubmed publisher
    ..of ER-beta in colon tumorigenesis, and (c) assessed the chemopreventive efficacy of raloxifene against azoxymethane (AOM)-induced colon carcinogenesis using aberrant crypt foci (ACF) as surrogate end point marker...
  55. Muralikrishnan G, Dinda A, Shakeel F. Immunomodulatory effects of Withania somnifera on azoxymethane induced experimental colon cancer in mice. Immunol Invest. 2010;39:688-98 pubmed publisher
    The efficacy of Withania somnifera on immunomodulation was tested in experimental azoxymethane induced colon cancer in mice. Azoxymethane is a potential carcinogen to induce the colon cancer in Swiss albino mice...
  56. Alizadeh A, Khaniki M, Azizian S, Mohaghgheghi M, Sadeghizadeh M, Najafi F. Chemoprevention of azoxymethane-initiated colon cancer in rat by using a novel polymeric nanocarrier--curcumin. Eur J Pharmacol. 2012;689:226-32 pubmed publisher
    ..to investigate the preventive effects of polymeric nanocarrier-curcumin (PNCC) on colon carcinogenesis in an azoxymethane-induced rat tumor. Forty rats were divided into control, curcumin- and PNCC-treated groups...
  57. Kobaek Larsen M, Christensen L, Vach W, Ritskes Hoitinga J, Brandt K. Inhibitory effects of feeding with carrots or (-)-falcarinol on development of azoxymethane-induced preneoplastic lesions in the rat colon. J Agric Food Chem. 2005;53:1823-7 pubmed
    ..of dietary amounts of carrot or corresponding amounts of (-)-(3R)-falcarinol from carrots on development of azoxymethane (AOM)-induced colon preneoplastic lesions were examined in male BDIX rats...
  58. Ju J, Nolan B, Cheh M, Bose M, Lin Y, Wagner G, et al. Voluntary exercise inhibits intestinal tumorigenesis in Apc(Min/+) mice and azoxymethane/dextran sulfate sodium-treated mice. BMC Cancer. 2008;8:316 pubmed publisher
    ..The present study investigated the effects of voluntary exercise on intestinal tumor formation in two different animal models, Apc(Min/+) mice and azoxymethane (AOM)/dextran sulfate sodium (DSS)-treated mice.
  59. Olivo Marston S, Hursting S, Lavigne J, Perkins S, Maarouf R, Yakar S, et al. Genetic reduction of circulating insulin-like growth factor-1 inhibits azoxymethane-induced colon tumorigenesis in mice. Mol Carcinog. 2009;48:1071-6 pubmed publisher
    ..We conducted a pilot study to assess the impact of liver-specific IGF-1 deficiency on azoxymethane (AOM)-induced colon tumors...
  60. Borinstein S, Conerly M, Dzieciatkowski S, Biswas S, Washington M, Trobridge P, et al. Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model. Mol Carcinog. 2010;49:94-103 pubmed publisher
    ..Consequently, we assessed the role of aberrant DNA methylation in the azoxymethane (AOM) rodent model of colon cancer...
  61. Ashokkumar P, Sudhandiran G. Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis. Biomed Pharmacother. 2008;62:590-7 pubmed publisher
    The modifying effect of dietary exposure to a flavonoid, luteolin (LUT) during the azoxymethane (AOM)-induced colon carcinogenesis was investigated in this study...
  62. Budda S, Butryee C, Tuntipopipat S, Rungsipipat A, Wangnaithum S, Lee J, et al. Suppressive effects of Moringa oleifera Lam pod against mouse colon carcinogenesis induced by azoxymethane and dextran sodium sulfate. Asian Pac J Cancer Prev. 2011;12:3221-8 pubmed
    ..The present study was conducted to investigate chemopreventive effects on azoxymethane (AOM)-initiated and dextran sodium sulfate (DSS)-promoted colon carcinogenesis in mice...
  63. Hata K, Kubota M, Shimizu M, Moriwaki H, Kuno T, Tanaka T, et al. Monosodium glutamate-induced diabetic mice are susceptible to azoxymethane-induced colon tumorigenesis. Carcinogenesis. 2012;33:702-7 pubmed publisher
    ..experimental obese and diabetic mice produced by monosodium glutamate (MSG) treatment are susceptible to azoxymethane (AOM)-induced colon tumorigenesis using early biomarkers, aberrant crypts foci (ACF) and ?-catenin-accumulated ..
  64. Velmurugan B, Singh R, Tyagi A, Agarwal R. Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats. Cancer Prev Res (Phila). 2008;1:376-84 pubmed publisher
    ..efficacy studies in human colorectal cancer cells, we investigated the effects of its dietary feeding on azoxymethane (AOM)-induced aberrant crypt foci (ACF) formation and associated biomarkers in male Fisher 344 rats...
  65. Ito K, Ishigamori R, Mutoh M, Ohta T, Imai T, Takahashi M. Ay allele promotes azoxymethane-induced colorectal carcinogenesis by macrophage migration in hyperlipidemic/diabetic KK mice. Cancer Sci. 2013;104:835-43 pubmed publisher
    ..that type 2 diabetes model KK-Ay/TaJcl (KK-Ay) mice develop tumors within a short period after treatment with azoxymethane (AOM). However, factors that contribute to the promotion of carcinogenesis have not been clarified...
  66. Kubota M, Shimizu M, Sakai H, Yasuda Y, Ohno T, Kochi T, et al. Renin-angiotensin system inhibitors suppress azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice. Biochem Biophys Res Commun. 2011;410:108-13 pubmed publisher
    ..and angiotensin-II type 1 receptor blocker (ARB), both of which inhibit the RAS, on the development of azoxymethane (AOM)-initiated colonic premalignant lesions in C57BL/KsJ-db/db (db/db) obese mice...
  67. Shimizu K, Das S, Baba M, Matsuura Y, Kanazawa K. Dietary artepillin C suppresses the formation of aberrant crypt foci induced by azoxymethane in mouse colon. Cancer Lett. 2006;240:135-42 pubmed
    ..In this study, artepillin C was tested for colon cancer-preventing activity using azoxymethane-challenged ddY mice...
  68. Lai C, Tsai M, Cheng A, Li S, Lo C, Wang Y, et al. Chemoprevention of colonic tumorigenesis by dietary hydroxylated polymethoxyflavones in azoxymethane-treated mice. Mol Nutr Food Res. 2011;55:278-90 pubmed publisher
    ..Here we investigated the chemopreventive effects and underlying molecular mechanisms of dietary administration of hydroxylated PMFs in an azoxymethane (AOM)-induced colonic tumorigenesis model.
  69. Suzuki R, Kohno H, Sugie S, Nakagama H, Tanaka T. Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice. Carcinogenesis. 2006;27:162-9 pubmed
    We have recently developed a mouse model for colitis-related colon carcinogenesis by a combined treatment with azoxymethane (AOM) and dextran sodium sulfate (DSS) in male ICR mice...
  70. Shimizu M, Shirakami Y, Iwasa J, Shiraki M, Yasuda Y, Hata K, et al. Supplementation with branched-chain amino acids inhibits azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice. Clin Cancer Res. 2009;15:3068-75 pubmed publisher
    ..The present study examined the effects of BCAA on the development of azoxymethane (AOM)-initiated colonic premalignant lesions in C57BL/KsJ-db/db (db/db) mice that were obese and had ..
  71. Fujise T, Iwakiri R, Kakimoto T, Shiraishi R, Sakata Y, Wu B, et al. Long-term feeding of various fat diets modulates azoxymethane-induced colon carcinogenesis through Wnt/beta-catenin signaling in rats. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1150-6 pubmed
    ..We investigated whether various dietary fats affected the Wnt signaling pathway of colon tumorigenesis in azoxymethane (AOM)-treated rats...
  72. Westley C, McIver C, Abbott C, Le Leu R, Benkendorff K. Enhanced acute apoptotic response to azoxymethane-induced DNA damage in the rodent colonic epithelium by Tyrian purple precursors: a potential colorectal cancer chemopreventative. Cancer Biol Ther. 2010;9:371-9 pubmed
    ..extract (ME), containing a mixture of the cytotoxins tyrindoleninone and 6-bromoisatin, was assessed in an azoxymethane (AOM) rodent model...
  73. Bousserouel S, Kauntz H, Gosse F, Bouhadjar M, Soler L, Marescaux J, et al. Identification of gene expression profiles correlated to tumor progression in a preclinical model of colon carcinogenesis. Int J Oncol. 2010;36:1485-90 pubmed
    The rat azoxymethane (AOM)-induced colon carcinogenesis model provides useful information for understanding human colorectal neoplasia...
  74. Carroll R, Goodlad R, Poole A, Tyner A, Robey R, Swanson S, et al. Reduced susceptibility to azoxymethane-induced aberrant crypt foci formation and colon cancer in growth hormone deficient rats. Growth Horm IGF Res. 2009;19:447-56 pubmed publisher
    ..evaluate the role of GH in colon carcinogenesis, we examined the formation of aberrant crypt foci (ACFs) and tumor development in wild type (WT) and GH-deficient, spontaneous dwarf rats (SDRs) exposed to the carcinogen azoxymethane (AOM).
  75. Xiao R, Carter J, Linz A, Ferguson M, Badger T, Simmen F. Dietary whey protein lowers serum C-peptide concentration and duodenal SREBP-1c mRNA abundance, and reduces occurrence of duodenal tumors and colon aberrant crypt foci in azoxymethane-treated male rats. J Nutr Biochem. 2006;17:626-34 pubmed
    ..WPH) for inhibitory effects on the development of colon aberrant crypt foci (ACF) and intestinal tumors in azoxymethane (AOM)-treated rats...
  76. Borrelli F, Capasso R, Aviello G, Di Carlo G, Izzo A, Mascolo N, et al. Senna and the formation of aberrant crypt foci and tumors in rats treated with azoxymethane. Phytomedicine. 2005;12:501-5; discussion 505 pubmed
    ..senna pod extract (SE) treatment on either healthy rats or rats treated with an initiating tumor agent (azoxymethane--AOM) has been studied...
  77. Tammali R, Reddy A, Ramana K, Petrash J, Srivastava S. Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation. Carcinogenesis. 2009;30:799-807 pubmed publisher
    ..we investigated the mediation of AR in the formation of colonic preneoplastic aberrant crypt foci (ACF) using azoxymethane (AOM)-induced colon cancer mice model...
  78. Ohmori H, Luo Y, Fujii K, Sasahira T, Shimomoto T, Denda A, et al. Dietary linoleic acid and glucose enhances azoxymethane-induced colon cancer and metastases via the expression of high-mobility group box 1. Pathobiology. 2010;77:210-7 pubmed publisher
    ..High-mobility group box 1 (HMGB1) was closely associated with progression and metastasis of colorectal cancer...
  79. Plate A, Gallaher D. Effects of indole-3-carbinol and phenethyl isothiocyanate on colon carcinogenesis induced by azoxymethane in rats. Carcinogenesis. 2006;27:287-92 pubmed
    ..Diets were fed for 2 weeks before and 10 weeks after administration of the colon carcinogen azoxymethane. Precancerous lesion (aberrant crypt foci, ACF) number in the distal colon was significantly lower in both high-..
  80. Morioka T, Suzui M, Nabandith V, Inamine M, Aniya Y, Nakayama T, et al. Modifying effects of Terminalia catappa on azoxymethane-induced colon carcinogenesis in male F344 rats. Eur J Cancer Prev. 2005;14:101-5 pubmed
    ..of an herb, Terminalia catappa (TC), were investigated on rat colon carcinogenesis induced by a carcinogen azoxymethane (AOM)...
  81. Norazalina S, Norhaizan M, Hairuszah I, Norashareena M. Anticarcinogenic efficacy of phytic acid extracted from rice bran on azoxymethane-induced colon carcinogenesis in rats. Exp Toxicol Pathol. 2010;62:259-68 pubmed publisher
    ..the potential of phytic acid extracted from rice bran in the suppression of colon carcinogenesis induced by azoxymethane (AOM) in rats. Seventy-two male Sprague-Dawley rats were divided into 6 groups with 12 rats in each group...
  82. Feregrino Pérez A, Berumen L, García Alcocer G, Guevara Gonzalez R, Ramos Gomez M, Reynoso Camacho R, et al. Composition and chemopreventive effect of polysaccharides from common beans (Phaseolus vulgaris L.) on azoxymethane-induced colon cancer. J Agric Food Chem. 2008;56:8737-44 pubmed publisher
    ..vulgaris L) cv. Negro 8025 on azoxymethane (AOM) induced colon cancer in rats...
  83. Chiou Y, Tsai M, Nagabhushanam K, Wang Y, Wu C, Ho C, et al. Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway. J Agric Food Chem. 2011;59:2725-33 pubmed publisher
    ..In this study, we investigated whether RS and PS could prevent the azoxymethane (AOM)-induced colon tumorigenesis via antioxidant action and to explore possible molecular mechanisms...
  84. Anilakumar K, Sudarshanakrishna K, Chandramohan G, Ilaiyaraja N, Khanum F, Bawa A. Effect of Aloe vera gel extract on antioxidant enzymes and azoxymethane-induced oxidative stress in rats. Indian J Exp Biol. 2010;48:837-42 pubmed
    ..was undertaken with a view to study the effect of oral feeding of 2% Aloe vera gel extract (AGE) for 30 days on azoxymethane (AOM)-induced oxidative stress in rats...