bethanechol compounds

Summary

Summary: Quaternary ammonium compounds that include BETHANECHOL.

Top Publications

  1. Wein A, English W, Whitmore K. Office urodynamics. Urol Clin North Am. 1988;15:609-23 pubmed
    ..The practicing urologist should at least have access to filling cystometry, flowmetry, residual urine determination, and voiding cystourethrography. All but the last named are certainly compatible with any office practice...
  2. Saito M, Longhurst P, Tammela T, Wein A, Levin R. Effects of partial outlet obstruction of the rat urinary bladder on micturition characteristics, DNA synthesis and the contractile response to field stimulation and pharmacological agents. J Urol. 1993;150:1045-51 pubmed
  3. Thor P, Laskiewcz J, Maczka M, Konturek S. Role of cholecystokinin in postprandial and vagally stimulated duodenal and gallbladder motility in dogs. J Physiol Pharmacol. 1991;42:381-8 pubmed
    ..We conclude that CCK contributes to the MMC related alterations in the GB motor activity and is essential in cholinergic stimulation induced of the GB emptying but not in vagally induced duodenal and GB motility...
  4. McKinney M, Miller J, Gibson V, Nickelson L, Aksoy S. Interactions of agonists with M2 and M4 muscarinic receptor subtypes mediating cyclic AMP inhibition. Mol Pharmacol. 1991;40:1014-22 pubmed
    ..However, the rat striatal and N1E-115 M4 receptor differed in their binding of oxotremorine and pilocarpine, indicating that these two M4 systems were not pharmacologically identical.(ABSTRACT TRUNCATED AT 400 WORDS)..
  5. Spessert R, Vollrath L. Muscarinic agonists have no measurable effect on cGMP formation of rat pinealocytes. Brain Res Bull. 1993;32:589-92 pubmed
    ..Because muscarinic agonists are known to stimulate pineal inositol phosphate (Ip) formation we suspect that muscarine-related Ip formation does not affect cGMP formation in rat pineal gland...
  6. Azpiroz F, Malagelada J. Importance of vagal input in maintaining gastric tone in the dog. J Physiol. 1987;384:511-24 pubmed
    ..6. We conclude that gastric tone during fasting is maintained by a cholinergic input, which is vagally mediated at both the cervical and the supradiaphragmatic levels...
  7. Greenberg G. Influence of vagal integrity on gastrin and somatostatin release in dogs. Gastroenterology. 1987;93:994-1001 pubmed
  8. Pazo J, Vaccaro M, Tumilasci O, Murer G, Calvo E. Changes in pancreatic exocrine secretion after repeated haloperidol administration. J Auton Nerv Syst. 1989;28:189-92 pubmed
    ..From these findings it is concluded that repeated haloperidol treatment produces an increase of basal pancreatic secretion, which is probably the result of changes in the sensitivity of dopamine receptors of the gland...
  9. Stallard D, Edes T. Muscarinic poisoning from medications and mushrooms. A puzzling symptom complex. Postgrad Med. 1989;85:341-5 pubmed
    ..Muscarinic toxicity due to medications necessitates an adjustment in drug dosage. In mushroom poisoning that produces primarily muscarinic effects, atropine is the treatment of choice...

More Information

Publications62

  1. Hong S, Ko L, Ho L, Fong J. Somatostatin modulation of neurally mediated pepsinogen secretion from frog esophageal mucosa. Biochim Biophys Acta. 1988;968:401-7 pubmed
    ..These results seem to indicate that somatostatin or somatostatin-like immunoreactivity may play a modulatory role in neurally mediated pepsinogen secretion in the frog esophagus...
  2. Khurana R. Cholinergic dysfunction in Shy-Drager syndrome: effect of the parasympathomimetic agent, bethanechol. Clin Auton Res. 1994;4:5-13 pubmed
    ..It is suggested that the Shy-Drager syndrome is primarily a preganglionic cholinergic disorder with transsynaptic degeneration accounting for the development of postganglionic cholinergic as well as adrenergic dysfunction...
  3. Levin R, Hypolite J, Longhurst P, Wein A. Comparison of the contractile and metabolic effects of muscarinic stimulation with those of KCl. Pharmacology. 1991;42:142-50 pubmed
    ..1) Both bethanechol and KCl stimulate a sharp decrease in the NADH/NAD ratio, a rapid increase in intracellular-free calcium, and a slower increase in contractile force.(ABSTRACT TRUNCATED AT 250 WORDS)..
  4. Uchida K, Mitsuma T, Morise K, Kaneko H, Nagai H, Furusawa A, et al. The role of thyrotropin-releasing hormone (TRH) in the pathogenesis of water-immersion stress in rats--inhibition of TRH release from the stomach by atropine, ranitidine or omeprazole. Gastroenterol Jpn. 1993;28:1-9 pubmed
    ..Furthermore, omeprazole has an inhibitory effect on TRH release under stress ulcer...
  5. Levin R, Hayes L, Zhao Y, Wein A. Effect of pinacidil on spontaneous and evoked contractile activity. Pharmacology. 1992;45:1-8 pubmed
    ..7) Pinacidil was a noncompetitive or mixed inhibitor of both methoxamine and bethanechol stimulation, whereas it was a competitive inhibitor of KCl stimulation.(ABSTRACT TRUNCATED AT 250 WORDS)..
  6. Kudlacz E, Gerald M, Wallace L. Effects of diabetes and diuresis on contraction and relaxation mechanisms in rat urinary bladder. Diabetes. 1989;38:278-84 pubmed
    ..In contrast, we found no evidence for loss of sensory nerve function in the diabetic bladder, at least at the organ level, because no diabetes- or diuresis-induced changes were observed in responsiveness to substance P or capsaicin...
  7. Armstead W, Mirro R, Leffler C, Busija D. Acetylcholine produces cerebrovascular constriction through activation of muscarinic-1 receptors in the newborn pig. J Pharmacol Exp Ther. 1988;247:926-33 pubmed
  8. Witkin J. Central and peripheral muscarinic actions of physostigmine and oxotremorine on avoidance responding of squirrel monkeys. Psychopharmacology (Berl). 1989;97:376-82 pubmed
    ..Response rate increases after administration of oxotremorine or physostigmine in monkeys treated with atropine may reflect a non-muscarinic action of atropine, unmasked by the presence of cholinomimetics...
  9. Janssen L, Daniel E. Pre- and postjunctional muscarinic receptors in canine bronchi. Am J Physiol. 1990;259:L304-14 pubmed
    ..The non-M1 agonists and antagonists had no such effects. These findings indicate that the postjunctional receptors are of the M3 subtype, and that the inhibitory receptors on the cholinergic nerve endings are of the M1 subtype...
  10. Fukudo S, Virnelli S, Kuhn C, Cochrane C, Feinglos M, Surwit R. Muscarinic stimulation and antagonism and glucoregulation in nondiabetic and obese hyperglycemic mice. Diabetes. 1989;38:1433-8 pubmed
  11. Wheeler J, Culkin D, Walter J, Flanigan R. Female urinary retention. Urology. 1990;35:428-32 pubmed
    ..Although no one test can accurately differentiate neurogenic from nonneurogenic female urinary retention, careful neurourologic evaluation will help guide us to more appropriate management...
  12. Imamura K, Kasamatsu T. Interaction of noradrenergic and cholinergic systems in regulation of ocular dominance plasticity. Neurosci Res. 1989;6:519-36 pubmed
    ..We thus conclude that the involvement of the muscarinic ACh system in ocular dominance plasticity is secondary to that of the NA-beta-adrenoreceptor system...
  13. Glavin G, Brandes L. Antiulcerogenic and antisecretory effects of a novel diphenylmethane derivative and antiestrogen binding site ligand. Can J Physiol Pharmacol. 1988;66:1139-43 pubmed
    ..These findings support the likelihood that the site of action of DPPE is different from that of verapamil, and that an effect on prostaglandins may, at least in part, contribute to its antiulcer and apparent cytoprotective effects...
  14. Wright R, Blair West J, Gibson A, Shulkes A. Evidence against the involvement of vasoactive intestinal peptide in ovine parotid secretion and blood flow. Clin Exp Pharmacol Physiol. 1991;18:469-74 pubmed
    ..5. The results indicate that exogenous VIP can affect the flow and composition of ovine parotid secretion but was not involved in the response to secretomotor nerve stimulation...
  15. Soejima O, Katsuragi T, Furukawa T. Opposite modulation by muscarinic M1 and M3 receptors of acetylcholine release from guinea pig ileum as measured directly. Eur J Pharmacol. 1993;249:1-6 pubmed
  16. Mitchell M, Markovitz D, Killen P, Braun D. Bilateral renal parenchymal malacoplakia presenting as fever of unknown origin: case report and review. Clin Infect Dis. 1994;18:704-18 pubmed
    ..Malacoplakia should be considered in the evaluation of fever of unknown origin or of relapsing or refractory urinary tract infection. Therapy with antimicrobial agents capable of intracellular penetration is recommended...
  17. Goerg K, Diener C, Diener M, Rummel W. Antisecretory effect of prostaglandin D2 in rat colon in vitro: action sites. Am J Physiol. 1991;260:G904-10 pubmed
    ..Consequently, PGD2 exerts an indirect antisecretory effect caused by an inhibition of enteric secretomotor neurons of both the submucosal and the mucosal plexus...
  18. Ramirez B, Richter J. Review article: promotility drugs in the treatment of gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 1993;7:5-20 pubmed
    ..Its most important role may be in the maintenance treatment of GERD either as a single agent or in combination therapy with an H2-antagonist after oesophagitis healing...
  19. Rikihisa Y, Johnson G, Wang Y, Reed S, Fertel R, Cooke H. Loss of absorptive capacity for sodium and chloride in the colon causes diarrhoea in Potomac horse fever. Res Vet Sci. 1992;52:353-62 pubmed
    ..These alterations are associated with malabsorption of sodium and chloride and could cause diarrhoea...
  20. O Donnell P, Hawkins W. Effects of subcutaneous bethanechol on bladder sensation during cystometry. Urology. 1993;41:452-4 pubmed
    ..Subcutaneous bethanechol appears to alter the bladder pressure and capacity at which the perception of desire to void and the sensation of maximum fullness occurs...
  21. Oosterbosch L, von der Ohe M, Valdovinos M, Kost L, Phillips S, Camilleri M. Effects of serotonin on rat ileocolonic transit and fluid transfer in vivo: possible mechanisms of action. Gut. 1993;34:794-8 pubmed
    ..In conclusion, 5HT is a potent pharmacological stimulant of transit across the rat ICJ in vivo; the action of 5HT is mediated partly through muscarinic neurones and several 5HT receptor subtypes...
  22. Brodish R, Kuvshinoff B, Fink A, McFadden D. Peptide YY inhibits pancreatic secretion via cholinergic pathways. J Surg Res. 1993;55:103-8 pubmed
    ..We conclude that extrapancreatic nerves do not mediate the inhibitory effects of PYY. The results suggest that PYY inhibits secretin/cholecystokinin-induced pancreatic response by an intrapancreatic cholinergic mechanism...
  23. Pohl R, Pandey G, Yeragani V, Balon R, Davis J, Berchou R. Beta-receptor responsiveness after desipramine treatment. Psychopharmacology (Berl). 1993;110:37-44 pubmed
    ..These findings suggest a decrease in the functional response of beta 1, but not beta 2, receptors after treatment with desipramine...
  24. Willenbucher R, Xie Y, Eysselein V, Snape W. Mechanisms of cAMP-mediated relaxation of distal circular muscle in rabbit colon. Am J Physiol. 1992;262:G159-64 pubmed
  25. Mastrapasqua G, Bonavina L, Anselmino M, Madia D, De Vido L, Baessato M, et al. [Pharmacologic effects and safety profile of bethanechol in the differential diagnosis of pseudo-anginal thoracic pain]. Minerva Cardioangiol. 1990;38:227-30 pubmed
    ..The Holter electrocardiographic study showed an isolated case of transient atrioventricular block...
  26. Wong W, Rahwan R, Stephens R. Examination of the potential antiulcer activity of the calcium antagonist propyl-methylenedioxyindene. III. Lack of effect on cysteamine-induced duodenal ulcers in rats. Pharmacology. 1990;41:215-23 pubmed
    ..The failure of pr-MDI to protect against duodenal ulceration is discussed in relation to its pharmacological mechanism of action and the pathogenetic mechanism of action of cysteamine...
  27. Young A, Levin R. The rat distal ileum has a reduced absorptive and secretory capacity compared with proximal ileum--is it to facilitate its chemosensing function?. Q J Exp Physiol. 1989;74:561-3 pubmed
  28. Keshavarzian A, Gordon J, Willson C, Urban G, Fields J. Chronic ethanol feeding produces a muscarinic receptor upregulation, but not a muscarinic supersensitivity in lower esophageal sphincter muscle. J Pharmacol Exp Ther. 1992;260:601-7 pubmed
  29. Hashimoto Y, Motoyoshi S, Maruyama H, Sakakida M, Yano T, Yamaguchi K, et al. The treatment of pheochromocytoma associated with pseudo-obstruction and perforation of the colon, hepatic failure, and DIC. Jpn J Med. 1990;29:341-6 pubmed
    ..The significant role of catecholamines in causing these symptoms is discussed, and the management of this relatively rare complication is reviewed...
  30. Wood J, Cheung L. Gastric contractions produce phasic changes in perfusion pressure. Am J Physiol. 1991;261:G158-65 pubmed
    ..Our results demonstrate that cholinergic-dependent contractions produce marked, phasic changes in gastric perfusion pressure...
  31. Lloris J, Bolant B, Gimeno L, Cejalvo D, Gimeno L, Calvo M, et al. Gastric juice and analysis of basal and stimulated secretion following treatment with rice-bran oil. Res Commun Chem Pathol Pharmacol. 1991;74:245-8 pubmed
    ..RBO also contains antioxidants such as alpha-tocopherol, which may likewise stimulate the synthesis of prostaglandins. RBO likely acts by increasing prostaglandin output, thus interfering with gastric HCl production...
  32. Lorinc Z, Derr J, Snider M, Lydic R. Defining origin of positive slope in hypercapnic ventilatory response curve. Am J Physiol. 1991;261:R747-51 pubmed
  33. Wallace J, Cucala M, Mugridge K, Parente L. Secretagogue-specific effects of interleukin-1 on gastric acid secretion. Am J Physiol. 1991;261:G559-64 pubmed
  34. Plummer M, Rittenhouse A, Kanevsky M, Hess P. Neurotransmitter modulation of calcium channels in rat sympathetic neurons. J Neurosci. 1991;11:2339-48 pubmed
  35. Levin R, Haugaard N, Levin S, Wein A. Creatine kinase activity in normal and hypertrophied rabbit urinary bladder tissue (following partial outlet obstruction). Mol Cell Biochem. 1991;106:143-9 pubmed
    ..4) Creatine kinase activity of control bladders showed linear kinetics with a Vmax = 1120 nmoles/mg protein/4 min and Km = 147 microM CP.(ABSTRACT TRUNCATED AT 250 WORDS)..
  36. Ciancio M, Vitiritti L, Dhar A, Chang E. Endotoxin-induced alterations in rat colonic water and electrolyte transport. Gastroenterology. 1992;103:1437-43 pubmed
    ..It was concluded that endotoxin significantly affects colonic transport function and may contribute to the development of diarrhea in inflammatory bowel diseases...
  37. Samadzadeh S, Tong Y, Wein A, Levin R. Influence of the bathing medium on the contractile responses of the rabbit urinary bladder. Pharmacology. 1992;45:99-106 pubmed
    ..It is speculated that the increases in contractile responsiveness of bladders incubated in MEM are related to the combination of amino acids, vitamins and other constituents of the cell culture medium...
  38. Hypolite J, Broderick G, Levin R. Correlation of contractile function of the rabbit corpus cavernosum with NADH fluorescence. Pharmacology. 1993;46:353-61 pubmed
    ..Methoxamine stimulated a substantial contraction of corporal smooth muscle which correlated with a rapid and significant decrease in NADH fluorescence.(ABSTRACT TRUNCATED AT 250 WORDS)..
  39. Andre P, Pompeiano O, White S. Activation of muscarinic receptors induces a long-lasting enhancement of Purkinje cell responses to glutamate. Brain Res. 1993;617:28-36 pubmed
    ..These data indicate that the cerebellar cholinergic system exerts a prominent modulatory influence on Purkinje cell excitability by acting through muscarinic receptors...
  40. Oleszczyńska Prost E. [Experimental studies on the influence of selected preparations on secretion of tear fluid. II: Light and transmission electron microscopy]. Klin Oczna. 1994;96:8-11 pubmed
    ..The greatest stimulation of the production of tear fluid was observed after treatment with mesna. Nearly similar results were obtained after bethanechol and slightly worse after ambroxol. The least potent drug was bromhexine...
  41. Bilgen A, Wein A, Zhao Y, Levin R. Effects of anoxia on the biphasic response of isolated strips of rabbit bladder to field stimulation, bethanechol, methoxamine and KCl. Pharmacology. 1992;44:283-9 pubmed
    ..3) Similarly, anoxia inhibited the plateau phase of the bladder body's response to bethanechol to a significantly and substantially greater degree than anoxia inhibited the peak contraction.(ABSTRACT TRUNCATED AT 250 WORDS)..
  42. Yan Z, Wood J, Cheung L. Platelet activating factor-induced changes in gastric motility and vascular resistance. Am J Surg. 1992;163:23-7 pubmed
    ..Our results demonstrate that gastric contractions markedly increase vascular resistance and support the hypothesis that hypercontractility may contribute to the development of mucosal ischemia during ulceration...
  43. Berridge C, Foote S. Effects of locus coeruleus activation on electroencephalographic activity in neocortex and hippocampus. J Neurosci. 1991;11:3135-45 pubmed
  44. Jaworek J, Konturek S. Effects of prostaglandin of E, F and I series, leukotriene C and platelet activating factor on amylase release from isolated rat pancreatic acini. J Physiol Pharmacol. 1993;44:365-81 pubmed
    ..These results indicate that PG inhibit, while PAF and LTC4 stimulate pancreatic enzyme secretion and thus could be implicated in the control of this secretion...
  45. Levin R, Longhurst P, Kato K, McGuire E, Elbadawi A, Wein A. Comparative physiology and pharmacology of the cat and rabbit urinary bladder. J Urol. 1990;143:848-52 pubmed
    ..It is clear that the in-vitro pharmacological responses of the cat urinary bladder are qualitatively and quantitatively different from that of the rabbit bladder...
  46. Tomomasa T, Hyman P, Hsu C, Jing J, Snape W. Development of the muscarinic receptor in rabbit gastric smooth muscle. Am J Physiol. 1988;254:G680-6 pubmed
    ..These results suggest that well-differentiated M2-muscarinic receptors are functional on rabbit gastric smooth muscle during the perinatal period...
  47. Young A, Levin R. Diarrhoea of famine and malnutrition: investigations using a rat model. 1. Jejunal hypersecretion induced by starvation. Gut. 1990;31:43-53 pubmed
    ..These results obtained with the rat model give a new insight into possible mechanisms by which the diarrhoea of human famine and malnutrition may be expressed...
  48. Barocelli E, Morini G, Ballabeni V, Lavezzo A, Impicciatore M. Effects of two new pirenzepine analogs on the contractile response of the guinea-pig oesophageal muscularis mucosae to acetylcholine, bethanechol, histamine and high potassium. Eur J Pharmacol. 1990;179:89-96 pubmed
    ..None of the compounds exhibited calcium antagonist properties. DF 545 inhibited the contractile responses to histamine, but DF 594 and pirenzepine did not...
  49. Schapira M, Henrion J, Heller F. The current status of gastric prokinetic drugs. Acta Gastroenterol Belg. 1990;53:446-57 pubmed
    ..Erythromycin, which has a dramatic effect on hypomotility in diabetic gastroparesis, and opioid antagonists, may constitute new groups of efficient prokinetic drugs...
  50. el Newihi H, Dooley C, Saad C, Staples J, Zeidler A, Valenzuela J. Impaired exocrine pancreatic function in diabetics with diarrhea and peripheral neuropathy. Dig Dis Sci. 1988;33:705-10 pubmed
    ..We conclude that diabetics with diarrhea and peripheral neuropathy exhibit impairment of their exocrine pancreatic secretion and possible mechanisms for this are discussed...
  51. Qiu B, Cho C, Ogle C. The influence of chronic nicotine treatment on stress-induced gastric ulceration and emptying rate in rats. Experientia. 1992;48:389-91 pubmed
    ..It is suggested that chronic nicotine administration produces hypersensitivity of the gastric muscarinic receptors; stomach hypermotility contributes to the ulcer-worsening action of the alkaloid...
  52. Llamas Elvira J, Sopena R, Martínez Paredes M, Jimenez Heffernan A, Gonzalez F, Torres M, et al. Muscarinic control of gallbladder dynamics. A study using 99Tcm-HIDA and cholinergic agonists and antagonists. Nucl Med Commun. 1990;11:813-7 pubmed
    ..01) in relation to bethanechol values following the first 30 min of the examination. Gallbladder emptying was observed in the study with pirenzepine, but was significantly inferior to the bethanechol values after the first 30 min...
  53. Harbaugh R. Novel CNS-directed drug delivery systems in Alzheimer's disease and other neurological disorders. Neurobiol Aging. 1989;10:623-9 pubmed
    ..The problems encountered in drug delivery to the brain, present experience with the clinical use of some novel drug delivery systems and the advantages and disadvantages of these systems will be discussed...