clorgyline

Summary

Summary: An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.

Top Publications

  1. Seymour C, Mothersill C, Mooney R, Moriarty M, Tipton K. Monoamine oxidase inhibitors l-deprenyl and clorgyline protect nonmalignant human cells from ionising radiation and chemotherapy toxicity. Br J Cancer. 2003;89:1979-86 pubmed
    ..obtained were compared with the effects of the less-selective MAO-B inhibitor pargyline and the MAO-A inhibitor clorgyline. l-Deprenyl at a concentration of 10(-9) M protected the nontumorigenic cell line (HaCaT) and normal human ..
  2. Alia Klein N, Goldstein R, Kriplani A, Logan J, Tomasi D, Williams B, et al. Brain monoamine oxidase A activity predicts trait aggression. J Neurosci. 2008;28:5099-104 pubmed publisher
    ..in vivo in healthy nonsmoking men with positron emission tomography using a radioligand specific for MAO A (clorgyline labeled with carbon 11). Trait aggression was measured with the multidimensional personality questionnaire (MPQ)...
  3. Maragos W, Young K, Altman C, Pocernich C, Drake J, Butterfield D, et al. Striatal damage and oxidative stress induced by the mitochondrial toxin malonate are reduced in clorgyline-treated rats and MAO-A deficient mice. Neurochem Res. 2004;29:741-6 pubmed
    ..In rats treated with either of the specific MAO-A or -B inhibitors, clorgyline or deprenyl, respectively, malonate lesion volumes were reduced by 30% compared to controls...
  4. Kitanaka N, Kitanaka J, Takemura M. Repeated clorgyline treatment inhibits methamphetamine-induced behavioral sensitization in mice. Neurochem Res. 2005;30:445-51 pubmed
    ..p.), once per day for five consecutive days), male ICR mice were treated with clorgyline (1 mg/kg, subcutaneous, once per day for five consecutive days), a monoamine oxidase-A inhibitor...
  5. Dvorkin A, Culver K, Szechtman H. Differential effects of clorgyline on sensitization to quinpirole in rats tested in small and large environments. Psychopharmacology (Berl). 2006;186:534-43 pubmed
    Cotreatment with clorgyline shifts the development of sensitization to the D2/D3 dopamine receptor agonist quinpirole from locomotion to mouthing, an effect apparently unrelated to the monoamine oxidase inhibition property of clorgyline...
  6. Kitanaka N, Kitanaka J, Watabe K, Takemura M. Low-dose pretreatment with clorgyline decreases the levels of 3-methoxy-4-hydroxyphenylglycol in the striatum and nucleus accumbens and attenuates methamphetamine-induced conditioned place preference in rats. Neuroscience. 2010;165:1370-6 pubmed publisher
    The effect of treating rats with clorgyline, an irreversible monoamine oxidase-A (MAO-A) inhibitor, on methamphetamine (METH)-induced conditioned place preference (CPP) was investigated. Administering rats with METH (1.0 mg/kg i.p...
  7. Fowler J, Ding Y, Logan J, MacGregor R, Shea C, Garza V, et al. Species differences in [11C]clorgyline binding in brain. Nucl Med Biol. 2001;28:779-85 pubmed
    11C]Clorgyline selectively binds to MAO A in the human brain. This contrasts with a recent report that [11C]clorgyline (in contrast to other labeled MAO A inhibitors) is not retained in the rhesus monkey brain [4]...
  8. Culver K, Szechtman H. Clorgyline-induced switch from locomotion to mouthing in sensitization to the dopamine D2/D3 agonist quinpirole in rats: role of sigma and imidazoline I2 receptors. Psychopharmacology (Berl). 2003;167:211-8 pubmed
    The monoamine oxidase inhibitor (MAOI) clorgyline, blocks locomotor sensitization to the D(2)/D(3) dopamine agonist quinpirole and sensitizes self-directed mouthing behavior in rats by a mechanism independent of MAO inhibition...
  9. Ma J, Kubota F, Yoshimura M, Yamashita E, Nakagawa A, Ito A, et al. Crystallization and preliminary crystallographic analysis of rat monoamine oxidase A complexed with clorgyline. Acta Crystallogr D Biol Crystallogr. 2004;60:317-9 pubmed
    ..to treat MAO-related neurological disorders, rat MAOA was crystallized in a complex with the specific inhibitor clorgyline. Diffraction data were collected to 3.2 A resolution...

More Information

Publications103 found, 100 shown here

  1. Kitanaka N, Kitanaka J, Takemura M. Inhibition of methamphetamine-induced hyperlocomotion in mice by clorgyline, a monoamine oxidase-a inhibitor, through alteration of the 5-hydroxytriptamine turnover in the striatum. Neuroscience. 2005;130:295-308 pubmed
    ..Pretreatment of repeated s.c. administration of clorgyline (1 mg/kg, once per day for 5 consecutive days), a monoamine oxidase (MAO)-A inhibitor, blocked hyperlocomotion ..
  2. Kitanaka N, Kitanaka J, Tatsuta T, Watabe K, Morita Y, Takemura M. Methamphetamine reward in mice as assessed by conditioned place preference test with Supermex sensors: effect of subchronic clorgyline pretreatment. Neurochem Res. 2006;31:805-13 pubmed
    ..shown that methamphetamine (METH)-induced hyperlocomotion and behavioral sensitization in mice were inhibited by clorgyline, an irreversible monoamine oxidase inhibitor...
  3. Holmes A, Keniya M, Ivnitski Steele I, Monk B, Lamping E, Sklar L, et al. The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates. Antimicrob Agents Chemother. 2012;56:1508-15 pubmed publisher
    ..Nine compounds were identified as hits, and the monoamine oxidase A inhibitor (MAOI) clorgyline was identified as an inhibitor of two C. albicans ABC efflux pumps, CaCdr1p and CaCdr2p...
  4. Glynn D, Gibson H, Harte M, Reim K, Jones S, Reynolds G, et al. Clorgyline-mediated reversal of neurological deficits in a Complexin 2 knockout mouse. Hum Mol Genet. 2010;19:3402-12 pubmed publisher
    ..Chronic treatment with clorgyline, an irreversible inhibitor of monoamine oxidase A, restored hippocampal noradrenaline to normal levels (from 60 ..
  5. Logan J, Fowler J. Evidence for reduced arterial plasma input, prolonged lung retention and reduced lung monoamine oxidase in smokers. Nucl Med Biol. 2005;32:521-9 pubmed
    ..and B using positron emission tomography (PET) and the irreversible mechanism-based radiotracers [(11)C]-labeled clorgyline (CLG) and deprenyl (DEP) and their deuterated analogs (D CLG, D DEP)...
  6. Katayama S, Shigemi K, Cline M, Furuse M. Clorgyline inhibits orexin-A-induced arousal in layer-type chicks. J Vet Med Sci. 2011;73:471-4 pubmed
    ..Therefore, we simultaneously injected clorgyline, a specific inhibitor of MAO-A, with orexin-A and examined behavior of chicks...
  7. Banchelli G, Buffoni F, Raimondi L. On the presence of a clorgyline resistant benzylamine oxidase activity in mouse kidney. Pharmacol Res Commun. 1988;20:465-83 pubmed
    ..of three different strains (C3H, Swiss, C57b) of mouse kidney the exposure to a millimolar concentration of clorgyline reveals a benzylamine oxidative deaminating activity that is due to a clorgyline resistant amine oxidase (CRAO)...
  8. Duncan W, Johnson K, Wehr T. 5-HT agonist-induced phase-advances of the circadian pacemaker are diminished by chronic antidepressant drug treatment. Brain Res. 1999;815:126-30 pubmed
    ..Hamsters were treated chronically with the monoamine oxidase inhibitor (MAOI), clorgyline, and then injected with 8-OH-DPAT or vehicle (VEH) either 4 h before or after the onset of wheel-running...
  9. Hubalek F, Pohl J, Edmondson D. Structural comparison of human monoamine oxidases A and B: mass spectrometry monitoring of cysteine reactivities. J Biol Chem. 2003;278:28612-8 pubmed
    ..Cys5 and Cys266 were identified as the only residues modified by biotin-derivatized NEM in clorgyline-inactivated MAO A and pargyline-inactivated MAO B, respectively. The x-ray structure of MAO B (Binda, C...
  10. Ayala Lopez N, Thompson J, Watts S. Perivascular Adipose Tissue's Impact on Norepinephrine-Induced Contraction of Mesenteric Resistance Arteries. Front Physiol. 2017;8:37 pubmed publisher
    ..no reduction in oxidase activity in all sample types was observed with use of the monoamine oxidase inhibitors clorgyline (1 ?M) or pargyline (1 ?M). Inhibition of MAO-A/B or SSAO individually did not alter contraction to NE...
  11. Aulakh C, Cohen R, Dauphin M, McLellan C, Murphy D. Role of serotonergic input in the down-regulation of beta-adrenoceptors following long-term clorgyline treatment. Eur J Pharmacol. 1988;156:63-70 pubmed
    Administration of the selective monoamine oxidase (MAO) type A-inhibiting antidepressant clorgyline (1 mg/kg per day) to rats for 21 days caused a significant decrease in cortical [3H]dihydroalprenolol binding...
  12. Tadano T, Satoh S, Satoh N, Kisara K, Arai Y, Kim S, et al. Potentiation of para-hydroxyamphetamine-induced head-twitch response by inhibition of monoamine oxidase type A in the brain. J Pharmacol Exp Ther. 1989;250:254-60 pubmed
    After pretreatment with either clorgyline, a monoamine oxidase (MAO)-A-selective inhibitor, or pargyline, an MAO-B-selective inhibitor with less selectivity than l-deprenyl, i.c.v...
  13. Upadhyay A, Wang J, Edmondson D. Comparison of the structural properties of the active site cavities of human and rat monoamine oxidase A and B in their soluble and membrane-bound forms. Biochemistry. 2008;47:526-36 pubmed
  14. Zoccarato F, Cappellotto M, Alexandre A. Clorgyline and other propargylamine derivatives as inhibitors of succinate-dependent H(2)O(2) release at NADH:UBIQUINONE oxidoreductase (Complex I) in brain mitochondria. J Bioenerg Biomembr. 2008;40:289-96 pubmed publisher
    ..dependent O(2)(-) production (measured as H(2)O(2) release) is inhibited by propargylamine containing compounds (clorgyline, CGP 3466B, rasagiline and TVP-1012)...
  15. Mihalik J, Mašlanková J, Špakovská T, Mareková M, Hodorová I, Kušnír J, et al. Impact of 2 doses of clorgyline on the rat preimplantation embryo development and the monoamine levels in urine. Reprod Sci. 2010;17:734-41 pubmed publisher
    We have evaluated the impact of chronic administration of clorgyline, a potent monoamine oxidase A inhibitor and a former antidepressant, on the preimplantation embryo development in Wistar rats...
  16. Herraiz T. Evaluation of the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to toxic pyridinium cations by monoamine oxidase (MAO) enzymes and its use to search for new MAO inhibitors and protective agents. J Enzyme Inhib Med Chem. 2012;27:810-7 pubmed publisher
    ..b>Clorgyline and the ?-carbolines, harman and norharman, inhibited the oxidation of MPTP by MAO-A...
  17. Fredriksson A, Palomo T, Archer T. Effects of MAO inhibitors upon MPTP mice chronically treated with suprathreshold doses of L-dopa. Behav Pharmacol. 2000;11:571-81 pubmed
    ..c.). On the other hand, neither the irreversible MAO-A inhibitor, clorgyline, nor the mixed MAO inhibitor, phenelzine, produced any directly effective restorative increments...
  18. Jeong S, Han X, Hong S, Hwang J, Hwang J, Lee D, et al. Monoamine oxidase inhibitory coumarins from the aerial parts of Dictamnus albus. Arch Pharm Res. 2006;29:1119-24 pubmed
    ..5 and 0.6 microM, respectively) compared to MAO-A (IC50 1.3 and 34.6 microM, respectively). According to kinetic analyses derived by Lineweaver-Burk reciprocal plots, compounds 1 and 2 exhibited a competitive inhibition to MAO-B...
  19. Villarinho J, Oliveira S, Silva C, Cabreira T, Ferreira J. Involvement of monoamine oxidase B on models of postoperative and neuropathic pain in mice. Eur J Pharmacol. 2012;690:107-14 pubmed publisher
    ..Taken together, our results showed that MAO-B seems to exert a critical role in the development of postoperative and neuropathic pain. ..
  20. Phillips O, D Silva R, Bahta T, Sharaf L, Udo E, Benov L, et al. Synthesis and biological evaluation of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives. Eur J Med Chem. 2015;106:120-31 pubmed publisher
    ..were also less active as MAO-A and -B inhibitors compared with linezolid and the selective inhibitors clorgyline and pargyline...
  21. Goldstein D, Jinsmaa Y, Sullivan P, Holmes C, Kopin I, Sharabi Y. Comparison of Monoamine Oxidase Inhibitors in Decreasing Production of the Autotoxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde in PC12 Cells. J Pharmacol Exp Ther. 2016;356:483-92 pubmed publisher
    ..Catechol concentrations were measured in cells and medium after incubation with the irreversible MAO-A inhibitor clorgyline, three reversible MAO-A inhibitors, or the MAO-B inhibitors selegiline or rasagiline for 180 minutes...
  22. Ro J, Lee S, Lee K, Lee M. Inhibition of type A monoamine oxidase by coptisine in mouse brain. Life Sci. 2001;70:639-45 pubmed
    ..These results suggest that coptisine is a potent reversible inhibitor of MAO-A, and that coptisine functions to regulate the catecholamine content. ..
  23. Mihalik J, Maslankova J, Hodorova I, Ferenc P, Rybarova S, Marekova M. Relationship between serotonin and norepinephrine levels and the preimplantation embryo development in rat. Bratisl Lek Listy. 2011;112:52-7 pubmed
    We have evaluated the impact of chronic administration of clorgyline, a potent monoamine oxidase A inhibitor and a former antidepressant, on the preimplantation embryo development in Wistar rats...
  24. Fowler J, Wang G, Volkow N, Logan J, Franceschi D, Franceschi M, et al. Evidence that gingko biloba extract does not inhibit MAO A and B in living human brain. Life Sci. 2000;66:PL141-6 pubmed
    ..MAO A and B in 10 subjects treated for 1 month with 120 mg/day of the Ginkgo biloba extract EGb 761, using [11C]clorgyline and [11C]L-deprenyl-D2 to measure MAO A and B respectively...
  25. Shioda K, Nisijima K, Kasai M, Yoshino T, Kato S. Risperidone attenuates the increase of extracellular nitric oxide and glutamate levels in serotonin syndrome animal models. Neurosci Lett. 2012;528:22-6 pubmed publisher
    ..The second model was induced by the administration of clorgyline, an MAO-A inhibitor, and 5-hydroxy-l-tryptophan, a precursor of 5-HT...
  26. Halberstadt A. Behavioral and pharmacokinetic interactions between monoamine oxidase inhibitors and the hallucinogen 5-methoxy-N,N-dimethyltryptamine. Pharmacol Biochem Behav. 2016;143:1-10 pubmed publisher
    ..effect on PPI when tested 45-min post-injection but disrupted PPI in animals pretreated with the MAO-A inhibitor clorgyline or the MAO-A/B inhibitor pargyline...
  27. Honda M, Imaida K, Tanabe M, Ono H. Endogenously released 5-hydroxytryptamine depresses the spinal monosynaptic reflex via 5-HT1D receptors. Eur J Pharmacol. 2004;503:55-61 pubmed
    ..These results suggest that 5-HT released from serotonergic terminals depresses monosynaptic reflex transmission via 5-HT1D receptors...
  28. Popova D, Forsblad A, Hashemian S, Jacobsson S. Non-Serotonergic Neurotoxicity by MDMA (Ecstasy) in Neurons Derived from Mouse P19 Embryonal Carcinoma Cells. PLoS ONE. 2016;11:e0166750 pubmed publisher
    ..The MAO inhibitors clorgyline and deprenyl, and the SERT inhibitor fluoxetine, per se or in combination, were not able to mimic the toxic ..
  29. Oxenkrug G, McIntyre I, McCauley R, Yuwiler A. Effect of selective monoamine oxidase inhibitors on rat pineal melatonin synthesis in vitro. J Pineal Res. 1988;5:99-109 pubmed
    Freshly cultured pineal glands respond to the monoamine oxidase A (MAO A) inhibitor clorgyline and to high concentrations of the MAO B inhibitor, deprenyl, with an increase in serotonin N-acetyltransferase activity and N-acetylated ..
  30. Esteban G, Allan J, Samadi A, Mattevi A, Unzeta M, Marco Contelles J, et al. Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease. Biochim Biophys Acta. 2014;1844:1104-10 pubmed publisher
    ..ASS234 was almost as effective as clorgyline (kinact/KI=3×10(6) min(-1)M(-1)) and was shown by structural studies to form the same N5 covalent adduct with ..
  31. Kushal S, Wang W, Vaikari V, Kota R, Chen K, Yeh T, et al. Monoamine oxidase A (MAO A) inhibitors decrease glioma progression. Oncotarget. 2016;7:13842-53 pubmed publisher
    ..This study shows that MAO A expression is increased in human glioma tissues and cell lines. MAO A inhibitors, clorgyline or the near-infrared-dye MHI-148 conjugated to clorgyline (NMI), were cytotoxic for glioma and decreased ..
  32. Fonseca A, Reis J, Silva T, Matos M, Bagetta D, Ortuso F, et al. Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis?. J Med Chem. 2017;60:7206-7212 pubmed publisher
    ..The benzopyrone sp2 oxygen atom was found to be position independent and a productive contributor for the ligand-enzyme complex stability. ..
  33. Youdim M, Banerjee D, Kelner K, Offutt L, Pollard H. Steroid regulation of monoamine oxidase activity in the adrenal medulla. FASEB J. 1989;3:1753-9 pubmed
    ..Therefore we suggest that the action of these steroid hormones on the intact adrenal medulla may be restricted to the endothelial cell component of this tissue. ..
  34. Clarke R, Harris J, Ogilvie J. Imidazoline I(2)-receptors and spinal reflexes in the decerebrated rabbit. Neuropharmacology. 2000;39:1904-12 pubmed
    ..and, as I(2)-receptors are closely associated with monoamine oxidase (MAO), the MAO inhibitors pargyline and clorgyline. In decerebrated rabbits with an intact spinal cord, intrathecal doses of 5-365 microg (cumulative) of the I(2)-..
  35. Nisijima K, Yoshino T, Yui K, Katoh S. Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome. Brain Res. 2001;890:23-31 pubmed
    ..When 2 mg/kg of clorgyline, a type-A monoamine oxidase inhibiting antidepressant, and 100 mg/kg of 5-hydroxy-L-tryptophan, a precursor of 5-..
  36. Olmos G, Gabilondo A, Miralles A, Escriba P, García Sevilla J. Chronic treatment with the monoamine oxidase inhibitors clorgyline and pargyline down-regulates non-adrenoceptor [3H]-idazoxan binding sites in the rat brain. Br J Pharmacol. 1993;108:597-603 pubmed
    ..2. Chronic treatment (14 days) with the monoamine oxidase (MAO) inhibitors clorgyline (0.3-10 mg kg-1, i.p.) and pargyline (10 mg kg-1, i.p.), but not with Ro 41-1049 (1 mg kg-1, i.p...
  37. Seth P, Fei Y, Li H, Huang W, Leibach F, Ganapathy V. Cloning and functional characterization of a sigma receptor from rat brain. J Neurochem. 1998;70:922-31 pubmed
    ..characterization of the cloned rat brain sigma receptor reveals that it exhibits severalfold higher affinity for clorgyline than for 1 ,3-di(2-tolyl)guanidine, it interacts with progesterone and testosterone, and its interaction with ..
  38. Wild M, McKillop D, Butters C. Determination of the human cytochrome P450 isoforms involved in the metabolism of zolmitriptan. Xenobiotica. 1999;29:847-57 pubmed
    ..b>Clorgyline, a selective inhibitor of monoamine oxidase A (MAO-A), markedly inhibited the microsomal formation of the indole ..
  39. Lane R, Rizk T, Chiaia N, Mooney R, Rhoades R. Effects of alterations of the vibrissae-related organization of thalamocortical axons upon the organization and outgrowth of intracortical connections in the barrelfield of the rat. Somatosens Mot Res. 2002;19:125-9 pubmed
    ..Cortical 5-HT was elevated in neonatal rats via chronic injections of clorgyline from birth until P-6...
  40. Nishizawa K, Torii K, Kawasaki A, Katada M, Ito M, Terashita K, et al. Antidepressant-like effect of Cordyceps sinensis in the mouse tail suspension test. Biol Pharm Bull. 2007;30:1758-62 pubmed
    ..Taken altogether, these results suggest that SCCS may elicit an antidepressant-like effect by affecting the adrenergic and dopaminergic systems, but not by affecting the serotonergic system...
  41. Drigues N, Poltyrev T, Bejar C, Weinstock M, Youdim M. cDNA gene expression profile of rat hippocampus after chronic treatment with antidepressant drugs. J Neural Transm (Vienna). 2003;110:1413-36 pubmed
    ..Animals were treated for 2 weeks with moclobemide, clorgyline and amitriptyline...
  42. Drukarch B, Flier J, Jongenelen C, Andringa G, Schoffelmeer A. The antioxidant anethole dithiolethione inhibits monoamine oxidase-B but not monoamine oxidase A activity in extracts of cultured astrocytes. J Neural Transm (Vienna). 2006;113:593-8 pubmed
    ..Considering the alleged contribution of MAO activity in general, and MAO-B in particular, to oxidative stress and neurodegeneration in PD, our data further support the neuroprotective potential of ADT. ..
  43. Guang H, Du G. High-throughput screening for monoamine oxidase-A and monoamine oxidase-B inhibitors using one-step fluorescence assay. Acta Pharmacol Sin. 2006;27:760-6 pubmed
    ..66 micromol/L, while that of benzylamine to MAO-B was 0.80 micromol/L. The IC(50) value of clorgyline to MAO-A was 2.99 nmol/L, and that of deprenyl to MAO-B was 7...
  44. Squires L, Rubakhin S, Wadhams A, Talbot K, Nakano H, Moroz L, et al. Serotonin and its metabolism in basal deuterostomes: insights from Strongylocentrotus purpuratus and Xenoturbella bocki. J Exp Biol. 2010;213:2647-54 pubmed publisher
    ..In contrast, 5-HT metabolism in X. bocki appears more similar to common protostome 5-HT catabolic pathways. ..
  45. Lundquist P, Blomquist G, Hartvig P, Hagberg G, Torstenson R, Hammarlund Udenaes M, et al. Validation studies on the 5-hydroxy-L-[beta-11C]-tryptophan/PET method for probing the decarboxylase step in serotonin synthesis. Synapse. 2006;59:521-31 pubmed
    ..by inhibition of the enzyme responsible for formation of the tissue metabolite, monoamine oxidase A, using clorgyline (2 mg/kg)...
  46. Mukherjee J, Yang Z. Monoamine oxidase A inhibition by fluoxetine: an in vitro and in vivo study. Synapse. 1999;31:285-9 pubmed
    ..In vitro binding affinities of six compounds, clorgyline, Ro 41-1049, deprenyl, fluoxetine, norfluoxetine and citalopram, were studied...
  47. Gerardy J, Dresse A. Comparative effects of dehydropirlindole and other compounds on rat brain monoamine oxidase type A. Prog Neuropsychopharmacol Biol Psychiatry. 2002;26:75-9 pubmed
    ..this work is to compare the inhibitory potency of DHP with three reference compounds: harmaline, befloxatone and clorgyline; the two former are reversible inhibitors and the later is an irreversible inhibitor of MAO-A...
  48. Logan J, Fowler J, Ding Y, Franceschi D, Wang G, Volkow N, et al. Strategy for the formation of parametric images under conditions of low injected radioactivity applied to PET studies with the irreversible monoamine oxidase A tracers [11C]clorgyline and deuterium-substituted [11C]clorgyline. J Cereb Blood Flow Metab. 2002;22:1367-76 pubmed
    ..A comparison was recently reported of the irreversible monoamine oxidase A (MAO A) radiotracers [11C]clorgyline (CLG) and deuterium-substituted [11C]clorgyline (CLG-D) in the human brain using region of interest (ROI) ..
  49. Nielsen D, Carey G, Gold L. Antidepressant-like activity of corticotropin-releasing factor type-1 receptor antagonists in mice. Eur J Pharmacol. 2004;499:135-46 pubmed
  50. He S, Grasing K. L-methamphetamine and selective MAO inhibitors decrease morphine-reinforced and non-reinforced behavior in rats; Insights towards selegiline's mechanism of action. Pharmacol Biochem Behav. 2006;85:675-88 pubmed
    ..under a progressive ratio schedule, chronic treatment was initiated with vehicle, L-methamphetamine, clorgyline (a selective inhibitor of MAO-A), or rasagiline (a selective inhibitor of MAO-B); with both MAO inhibitors ..
  51. Shumay E, Logan J, Volkow N, Fowler J. Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men. Epigenetics. 2012;7:1151-60 pubmed publisher
    ..DNA and subsequent sequencing of cloned DNA products) and measured brain MAO A levels (using PET and [(11)C]clorgyline, a radiotracer with specificity for MAO A) in 34 healthy non-smoking male volunteers...
  52. Datla K, Mitra S, Bhattacharya S. Serotonergic modulation of footshock induced aggression in paired rats. Indian J Exp Biol. 1991;29:631-5 pubmed
    ..show that centrally administered serotonin, the serotonin precursor, 5-hydroxytryptophan administered with clorgyline, a selective MAO A inhibitor, quipazine, a serotonin receptor agonist, and fluoxetine, a selective inhibitor of ..
  53. Indra B, Tadano T, Nakagawasai O, Arai Y, Yasuhara H, Ohizumi Y, et al. Suppressive effect of nantenine, isolated from Nandina domestica Thunberg, on the 5-hydroxy-L-tryptophan plus clorgyline-induced head-twitch response in mice. Life Sci. 2002;70:2647-56 pubmed
    ..25 and 1 mg/kg) inhibited the 5-hydroxy-L-tryptophan (l-5-HTP; 75 mg/kg, i.p.) plus monoamine oxidase inhibitor, clorgyline (1 mg/kg, i.p.)-induced HTR in a dose-dependent manner...
  54. Miklya I, Knoll J. Analysis of the effect of (-)-BPAP, a selective enhancer of the impulse propagation mediated release of catecholamines and serotonin in the brain. Life Sci. 2003;72:2915-21 pubmed
    ..Neither 250 ng/ml clorgyline, a selective inhibitor of MAO-A, nor 250 ng/ml lazabemide, a selective inhibitor MAO-B, was capable to ..
  55. Toda T, Hayakawa I, Matsubayashi Y, Tanaka K, Ikenaka K, Lu Q, et al. Termination of lesion-induced plasticity in the mouse barrel cortex in the absence of oligodendrocytes. Mol Cell Neurosci. 2008;39:40-9 pubmed publisher
    ..Our findings underscore a mechanistic distinction between the termination of thalamocortical axonal plasticity in the barrel cortex and that in the visual cortex, in which OL-derived Nogo-A/B was recently suggested to be essential...
  56. Zitova A, Hynes J, Kollar J, Borisov S, Klimant I, Papkovsky D. Analysis of activity and inhibition of oxygen-dependent enzymes by optical respirometry on the LightCycler system. Anal Biochem. 2010;397:144-51 pubmed publisher
    ..The panel included the MAO-A/B inhibitors clorgyline, toloxatone, deprenyl, and the COX-1/2 inhibitors niflumic acid, nimesulide, SC-560, ketoprofen, and ..
  57. Flamand V, Zhao H, Peehl D. Targeting monoamine oxidase A in advanced prostate cancer. J Cancer Res Clin Oncol. 2010;136:1761-71 pubmed publisher
    ..An irreversible inhibitor of MAOA, clorgyline, induced secretory differentiation in primary cultures of normal basal epithelial cells and high-grade PCa...
  58. Hovevey Sion D, Kopin I, Stull R, Goldstein D. Effects of monoamine oxidase inhibitors on levels of catechols and homovanillic acid in striatum and plasma. Neuropharmacology. 1989;28:791-7 pubmed
    ..DHPG) in plasma and the striatium were measured after inhibition of monoamine oxidase type A (MAO-A) by clorgyline (4 mg/kg i.p.), MAO-B by (-)deprenyl (1 mg/kg i.p.), both MAO-A and MAO-B by nialamide (75 mg/kg i.p...
  59. Fowler J, Volkow N, Wang G, Pappas N, Logan J, Shea C, et al. Brain monoamine oxidase A inhibition in cigarette smokers. Proc Natl Acad Sci U S A. 1996;93:14065-9 pubmed
    ..We compared brain MAO A in 15 nonsmokers and 16 current smokers with [11C]clorgyline and positron emission tomography (PET)...
  60. Boylan C, Bennett Clarke C, Crissman R, Mooney R, Rhoades R. Clorgyline treatment elevates cortical serotonin and temporarily disrupts the vibrissae-related pattern in rat somatosensory cortex. J Comp Neurol. 2000;427:139-49 pubmed
    ..Littermates were injected with either clorgyline (5 mg/kg) or sterile saline five times daily...
  61. Trejo F, Nekrassov V, Sitges M. Characterization of vinpocetine effects on DA and DOPAC release in striatal isolated nerve endings. Brain Res. 2001;909:59-67 pubmed
    ..In contrast to vinpocetine, the selective MAO-A inhibitor, clorgyline, increases DA and decreases DOPAC formation...
  62. Fowler J, Logan J, Ding Y, Franceschi D, Wang G, Volkow N, et al. Non-MAO A binding of clorgyline in white matter in human brain. J Neurochem. 2001;79:1039-46 pubmed
    b>Clorgyline is an irreversible inhibitor of monoamine oxidase (MAO A) which has been labeled with carbon-11 (C-11) and used to measure human brain MAO A with positron emission tomography (PET)...
  63. Fitzgerald D, Tipton K. Inhibition of monoamine oxidase modulates the behaviour of semicarbazide-sensitive amine oxidase (SSAO). J Neural Transm (Vienna). 2002;109:251-65 pubmed
    ..monoamine oxidase (MAO) inhibitor tranylcypromine, but not by the selective MAO-A and -B inhibitors, clorgyline and lazabemide...
  64. Csaba G, Kovacs P. Perinuclear localization of biogenic amines (serotonin and histamine) in rat immune cells. Cell Biol Int. 2006;30:861-5 pubmed
    EDAC fixation, which polymerizes biogenic amines, and clorgyline, which blocks monoamine oxydase, were used to demonstrate the perinuclear and nuclear localization of histamine and serotonin (5-HT) of immune cells in rat peritoneal fluid ..
  65. Nocito A, Dahm F, Jochum W, Jang J, Georgiev P, Bader M, et al. Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis. Gastroenterology. 2007;133:608-18 pubmed
    ..Serotonin degradation by monoamine oxidase A (MAO-A) was recently implicated as an important source of reactive oxygen species. We therefore tested the pathogenetic role of serotonin in a murine model of diet-induced steatohepatitis...
  66. Tang S, Chichester C, Kagan H. Comparative sensitivities of purified preparations of lysyl oxidase and other amine oxidases to active site-directed enzyme inhibitors. Connect Tissue Res. 1989;19:93-103 pubmed
    ..to warrant its consideration as an antifibrotic agent in vivo, while also revealing that aminoguanidine, clorgyline and deprenyl are sufficiently selective for diamine oxidase, monoamine oxidase A and monoamide oxidase B, ..
  67. Kitaichi Y, Inoue T, Nakagawa S, Izumi T, Koyama T. Effect of co-administration of subchronic lithium pretreatment and acute MAO inhibitors on extracellular monoamine levels and the expression of contextual conditioned fear in rats. Eur J Pharmacol. 2006;532:236-45 pubmed
    We investigated the effects of clorgyline [a selective MAO (monoamine oxidase inhibitor)-A inhibitor] and lazabemide (a selective MAO-B inhibitor) on extracellular serotonin, dopamine and noradrenaline concentrations in the medial ..
  68. Erickson D, Hollfelder S, Tenge J, Gohdes M, Burkhardt J, Krieter P. In vitro metabolism of the analgesic bicifadine in the mouse, rat, monkey, and human. Drug Metab Dispos. 2007;35:2232-41 pubmed
    ..b>Clorgyline, a specific inhibitor of MAO-A, was less effective in inhibiting M12 formation...
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    ..is normal in binocularly enucleated animals and in mice treated with the monoamine oxidase A (MAOA) inhibitor, clorgyline. In addition, our experiments using LGN slice cultures show that the expression of PCP4 and TCF7L2 in LGN slices ..
  70. Vavilova T, Ostrovskaya I, Axenova L, Buneeva O, Medvedev A. Monoamine oxidase and semicarbazide sensitive amine oxidase activities in normal and inflamed human dental pulp. Med Sci Monit. 2009;15:BR289-292 pubmed
    ..In other tissues SSAO is involved in oxidative stress and inflammation, but the role of MAO and SSAO in human pulp and changes of their activities in reversible pulpitis still remains poorly understood...
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    ..1 mM clorgyline, suggesting that MA is a substrate for the semicarbazide-sensitive amino oxidase (SSAO) activities which also ..
  72. Pepper J, Baumann M, Ayestas M, Rothman R. Inhibition of MAO-A fails to alter cocaine-induced increases in extracellular dopamine and norepinephrine in rat nucleus accumbens. Brain Res Mol Brain Res. 2001;87:184-9 pubmed
    ..present study, we tested the hypothesis that inhibition of catecholamine metabolism with the MAO-A inhibitor, clorgyline, might enhance cocaine-induced increases in extracellular dopamine and norepinephrine in rat nucleus accumbens...
  73. Sturza A, Mirica S, Duicu O, Gheorgheosu D, Noveanu L, Fira Mladinescu O, et al. Monoamine oxidase--a inhibition reverses endothelial dysfunction in hypertensive rat aortic rings. Rev Med Chir Soc Med Nat Iasi. 2013;117:165-71 pubmed
  74. Mukherjee J, Yang Z. Development of N-[3-(2',4'-dichlorophenoxy)-2-18F-fluoropropyl]-N-methylpropargylamine (18F-fluoroclorgyline) as a potential PET radiotracer for monoamine oxidase-A. Nucl Med Biol. 1999;26:619-25 pubmed
    ..Selectivity for MAO-A was demonstrated by the high affinity of clorgyline (IC50 = 39 nM) and lower affinity of (R)-deprenyl (IC50 > or = 100 microM) for the inhibition of 18F-..
  75. Barbelivien A, Nyman L, Haapalinna A, Sirvio J. Inhibition of MAO-A activity enhances behavioural activity of rats assessed using water maze and open arena tasks. Pharmacol Toxicol. 2001;88:304-12 pubmed
    ..MAO-B activities can influence cognitive processes in adult rats, we analysed whether chronic treatment with clorgyline, 1-deprenyl and pargyline could modify the performance of adult rats in a modified version of the water maze ..
  76. Fowler J, Logan J, Azzaro A, Fielding R, Zhu W, Poshusta A, et al. Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157. Neuropsychopharmacology. 2010;35:623-31 pubmed publisher
    ..Brain MAO-A levels were measured with positron emission tomography (PET) imaging and [(11)C]clorgyline in 15 normal men after oral dosing of CX157 (20-80 mg)...
  77. Manni M, De Siena G, Saba A, Marchini M, Dicembrini I, Bigagli E, et al. 3-Iodothyronamine: a modulator of the hypothalamus-pancreas-thyroid axes in mice. Br J Pharmacol. 2012;166:650-8 pubmed publisher
    ..in overnight fasted mice, under control conditions and after pretreatment with the MAO inhibitor clorgyline. T1AM (1.3, 6.6, 13, 20 and 26?µg·kg(-1) ) or vehicle were injected i.c.v...
  78. Marquez C, Poirier G, Cordero M, Larsen M, Groner A, Marquis J, et al. Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression. Transl Psychiatry. 2013;3:e216 pubmed publisher
    ..Our data emphasize the impact of biological factors triggered by peripubertal adverse experiences on the emergence of violent behaviors...
  79. Faradji Prevautel H, Cespuglio R, Jouvet M. Circadian rest-activity rhythms in the anophthalmic, monocular and binocular ZRDCT/An mice. Retinal and serotoninergic (raphe) influences. Brain Res. 1990;526:207-16 pubmed
    ..Further, a circadian variation of this signal is superimposed to that of the waking state amount. Such circadian variations are synchronized to the L/D cycle in C57 Black/6 animals and free running in the AN mice...
  80. Geha R, Rebrin I, Chen K, Shih J. Substrate and inhibitor specificities for human monoamine oxidase A and B are influenced by a single amino acid. J Biol Chem. 2001;276:9877-82 pubmed
    ..serotonin (5-hydroxytryptamine), and became more sensitive to deprenyl (MAO B-specific inhibitor) than to clorgyline (MAO A-specific inhibitor)...
  81. Dong W, Ni X. Norepinephrine metabolism in neuron: dissociation between 3,4-dihydroxyphenylglycol and 3,4-dihydroxymandelic acid pathways. Acta Pharmacol Sin. 2002;23:59-65 pubmed
    ..To investigate the pre-synaptic metabolism of norepinephrine (NE), judged by variations in plasma concentration of 3,4-dihydroxyphenylglycol (DHPG) and 3,4-dihydroxymandelic acid (DOMA)...
  82. Tranquilli Leali F, Artico M, Potenza S, Cavallotti C. Age-related changes of monoaminooxidases in rat cerebellar cortex. Eur J Histochem. 2003;47:81-6 pubmed
    ..The possibility that age-related changes in monoaminooxidase levels may be due to impaired energy production mechanisms and/or represent the consequence of reduced energetic needs is discussed...
  83. Dell Antone P, Ibnlkayat M, Drago D, Zatta P. Acidic vesicles of the endo-exocytic pathways as targets for some anti-monoamine oxidase drugs. Metab Brain Dis. 2009;24:713-22 pubmed
    ..In this paper, some anti-monoamine oxidase drugs (clorgyline, pargyline, amantadine and deprenyl), utilized as pharmacological treatment in some neurological disorders (e.g...
  84. Li P, Siddiqi I, Mottok A, Loo E, Wu C, Cozen W, et al. Monoamine oxidase A is highly expressed in classical Hodgkin lymphoma. J Pathol. 2017;243:220-229 pubmed publisher
    ..The MAOA inhibitor clorgyline reduced the growth of L1236 cells and U-HO1 cells, and shRNA knockdown of MAOA reduced the growth of L1236 cells...
  85. Duncan W, Johnson K, Wehr T. Increase of 5HT and VIP immunoreactivity within the hamster (Mesocricetus auratus) SCN during chronic MAOI treatment. Neurosci Lett. 1997;236:159-62 pubmed
    The effects of chronic treatment with the monoamine oxidase inhibitor (MAOI), clorgyline (CLG; 2 mg/kg per day) on serotonin (5HT) and vasoactive intestinal peptide (VIP) immunoreactivity (IR) within the hamster suprachiasmatic nucleus (..
  86. Adachi Y, Watanabe K, Higuchi H, Satoh T, Vizi E. Oxygen inhalation enhances striatal dopamine metabolism and monoamineoxidase enzyme inhibition prevents it: a microdialysis study. Eur J Pharmacol. 2001;422:61-8 pubmed
    ..1 or 1 mg kg(-1) of clorgyline, 1 or 10 mg kg(-1) of selegiline and 75 mg kg(-1) pargyline) or control solution...
  87. Richards T, Pazdernik T, Levant B. Clorgyline-induced modification of behavioral sensitization to quinpirole: effects on local cerebral glucose utilization. Brain Res. 2007;1160:124-33 pubmed
    ..after a sensitizing course of quinpirole, a D(2)/D(3) dopamine agonist, can be modified by the MAO(A) inhibitor clorgyline, by a mechanism apparently unrelated to its actions on MAO(A)...
  88. Wooters T, Bardo M. The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats. Behav Pharmacol. 2007;18:601-8 pubmed
    ..This study examined the effects of three MAOIs (phenelzine, clorgyline and pargyline) with varying selectivity for MAOA and MAOB in the nicotine drug discrimination procedure in rats...
  89. Sitges M, Aldana B, Chiu L, Nekrassov V. Characterization of phenytoin, carbamazepine, vinpocetine and clorgyline simultaneous effects on sodium channels and catecholamine metabolism in rat striatal nerve endings. Neurochem Res. 2009;34:470-9 pubmed publisher
    ..drugs (carbamazepine and phenytoin), a potential antiepileptic (vinpocetine) and a monoamine-oxidase inhibitor (clorgyline) on the simultaneous changes (detected by HPLC) on Glu, Asp, dopamine and DOPAC inside and outside striatal ..
  90. Schildhaus H, Riegel R, Hartmann W, Steiner S, Wardelmann E, Merkelbach Bruse S, et al. Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors, and malignant peripheral nerve sheath tumors. Hum Pathol. 2011;42:1667-75 pubmed publisher
    ..Our results suggest that dysregulation of lysine-specific demethylase 1 is associated with highly malignant sarcomas proposing them as molecular tumor markers as well as targets for the treatment of these tumor types...
  91. Tanabe M, Ono H, Fukuda H. Spinal alpha 1- and alpha 2-adrenoceptors mediate facilitation and inhibition of spinal motor transmission, respectively. Jpn J Pharmacol. 1990;54:69-77 pubmed
    ..In rats pretreated with the MAO inhibitor clorgyline-HCl (1 mg/kg, i.v.), L-3,4-dihydroxyphenylalanine (L-dopa) (5 mg/kg, i.v...
  92. Ikemoto K, Kitahama K, Maeda T, Jouvet M, Nagatsu I. Cholinergic neurons with monoamine oxidase type B (MAOB)-activity in the laterodorsal tegmental nucleus of the mouse. Neurosci Lett. 1999;271:53-6 pubmed
    ..revealed LDTg neurons with MAO-activity even after pharmacological suppression of MAOA-activity with clorgyline, a specific MAOA inhibitor, but not after pharmacological suppression of MAOB-activity with deprenyl, a specific ..