Summary: A polymeric amine that binds phosphate and is used to treat HYPERPHOSPHATEMIA in patients with kidney disease.
Moorthi R, Moe S. CKD-mineral and bone disorder: core curriculum 2011. Am J Kidney Dis. 2011;58:1022-36 pubmed publisher
Agarwal R. What can we learn from null randomized controlled trials?. J Am Soc Nephrol. 2013;24:691-3 pubmed publisher
Shan L, Siliciano R. Unraveling the relationship between microbial translocation and systemic immune activation in HIV infection. J Clin Invest. 2014;124:2368-71 pubmed publisher
..This study directly demonstrates that microbial translocation promotes the systemic immune activation associated with HIV-1/SIV infection. ..
Kristoff J, Haret Richter G, Ma D, Ribeiro R, Xu C, Cornell E, et al
. Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication. J Clin Invest. 2014;124:2802-6 pubmed publisher
..Here, we have demonstrated that treatment of acutely SIV-infected pigtailed macaques with the drug sevelamer, which binds microbial lipopolysaccharide in the gut, dramatically reduces immune activation and inflammation ..
Sandler N, Zhang X, Bosch R, Funderburg N, Choi A, Robinson J, et al
. Sevelamer does not decrease lipopolysaccharide or soluble CD14 levels but decreases soluble tissue factor, low-density lipoprotein (LDL) cholesterol, and oxidized LDL cholesterol levels in individuals with untreated HIV infection. J Infect Dis. 2014;210:1549-54 pubmed publisher
..Microbial translocation, which may cause inflammation, is decreased by sevelamer in patients undergoing hemodialysis...
St Peter W, Wazny L, Weinhandl E, Cardone K, Hudson J. A Review of Phosphate Binders in Chronic Kidney Disease: Incremental Progress or Just Higher Costs?. Drugs. 2017;77:1155-1186 pubmed publisher
..Recent meta-analyses suggest that sevelamer use results in lower mortality than use of calcium-containing phosphate binders...
Yaguchi A, Tatemichi S, Takeda H, Kobayashi M. PA21, a novel phosphate binder, improves renal osteodystrophy in rats with chronic renal failure. PLoS ONE. 2017;12:e0180430 pubmed publisher
..They were also freely fed a diet that contained PA21 (0.5, 1.5, and 5%), sevelamer hydrochloride (0.6 and 2%) or lanthanum carbonate hydrate (0.6 and 2%) for four weeks...