ethylenediamines

Summary

Summary: Derivatives of ethylenediamine (the structural formula NH2CH2CH2NH2).

Top Publications

  1. Meeusen J, Nowakowski A, Petering D. Reaction of metal-binding ligands with the zinc proteome: zinc sensors and N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine. Inorg Chem. 2012;51:3625-32 pubmed publisher
    ..TPEN also removed one of the two Zn(2+) ions per monomer from zinc-alcohol dehydrogenase and zinc-alkaline phosphatase, consistent with its ligand substitution reactivity with the zinc proteome...
  2. Shin J, Jung H, An Y, Cho Y, Cha S, Roe J. Graded expression of zinc-responsive genes through two regulatory zinc-binding sites in Zur. Proc Natl Acad Sci U S A. 2011;108:5045-50 pubmed publisher
    ..It enables bacteria to detect metal depletion with improved sensitivity and optimize gene-expression pattern...
  3. Nikonenko B, Protopopova M, Samala R, Einck L, Nacy C. Drug therapy of experimental tuberculosis (TB): improved outcome by combining SQ109, a new diamine antibiotic, with existing TB drugs. Antimicrob Agents Chemother. 2007;51:1563-5 pubmed
    ..5 log10 lower in SQ109-containing regimens...
  4. Marini M, Frabetti F, Canaider S, Dini L, Falcieri E, Poirier G. Modulation of caspase-3 activity by zinc ions and by the cell redox state. Exp Cell Res. 2001;266:323-32 pubmed
    ..Caspase-3 activity was found to resume upon mild Zn(2+) chelation. These results provide as well an experimental model from which apoptotic events upstream and downstream of caspase-3 activity can be examined...
  5. Lee J, Kim Y, Ra H, Kang S, Han S, Koh J, et al. The involvement of caspase-11 in TPEN-induced apoptosis. FEBS Lett. 2008;582:1871-6 pubmed publisher
    ..Although mitochondria-mediated caspase-9/-3 activation also contributed to TPEN-induced apoptosis, caspase-11 is likely a key inducible apoptosis-inducing protein...
  6. Jia L, Noker P, Coward L, Gorman G, Protopopova M, Tomaszewski J. Interspecies pharmacokinetics and in vitro metabolism of SQ109. Br J Pharmacol. 2006;147:476-85 pubmed
    ..P450 reaction phenotyping using recombinant cDNA-expressed human CYPs in conjunction with specific CYP inhibitors indicated that CYP2D6 and CYP2C19 were the predominant CYPs involved in SQ109 metabolism...
  7. Kurenova E, Hunt D, He D, Magis A, Ostrov D, Cance W. Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo. J Med Chem. 2009;52:4716-24 pubmed publisher
    ..Our data demonstrate that the FAK-VEGFR-3 interaction can be targeted by small druglike molecules and this interaction can provide the basis for highly specific novel cancer therapeutics...
  8. Donadelli M, Dalla Pozza E, Costanzo C, Scupoli M, Scarpa A, Palmieri M. Zinc depletion efficiently inhibits pancreatic cancer cell growth by increasing the ratio of antiproliferative/proliferative genes. J Cell Biochem. 2008;104:202-12 pubmed
    ..In this study, we suggest that zinc depletion may be an efficient strategy in the treatment of pancreatic cancer because of its reduced antiproliferative effect on normal cells...
  9. ELSAS S, Hazany S, Gregory W, Mody I. Hippocampal zinc infusion delays the development of afterdischarges and seizures in a kindling model of epilepsy. Epilepsia. 2009;50:870-9 pubmed publisher
    ..By blocking NMDA excitation or GABA inhibition, an excess of zinc may alter the excitability of hippocampal circuits, which contribute to the development of seizures...

More Information

Publications95

  1. Protopopova M, Hanrahan C, Nikonenko B, Samala R, Chen P, Gearhart J, et al. Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines. J Antimicrob Chemother. 2005;56:968-74 pubmed
    ..The aim of this study was to identify a candidate drug for clinical development from a previously synthesized combinatorial library based on the 1,2-ethylenediamine structure of ethambutol...
  2. Doctrow S, Huffman K, Marcus C, Tocco G, Malfroy E, Adinolfi C, et al. Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: structure-activity relationship studies. J Med Chem. 2002;45:4549-58 pubmed
    ..This supports the concept that salen-manganese complexes represent a class of SOD and, in particular, catalase mimetics potentially useful against ROS-associated diseases...
  3. Outten C, O Halloran T. Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis. Science. 2001;292:2488-92 pubmed
    ..Thus, cells exert tight control over cytosolic metal concentrations, even for relatively low-toxicity metals such as zinc...
  4. Sztretye M, Almassy J, Deli T, Szentesi P, Jung C, Dienes B, et al. Altered sarcoplasmic reticulum calcium transport in the presence of the heavy metal chelator TPEN. Cell Calcium. 2009;46:347-55 pubmed publisher
    ..88 +/- 0.10. These findings provide experimental evidence that TPEN directly modifies both the release of Ca2+ from and its reuptake into the SR...
  5. Lopez J, Redondo P, Salido G, Pariente J, Rosado J. N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine induces apoptosis through the activation of caspases-3 and -8 in human platelets. A role for endoplasmic reticulum stress. J Thromb Haemost. 2009;7:992-9 pubmed publisher
    ..Alternatively, apoptosis has been reported to be induced by endoplasmic reticulum (ER) stress, which is mainly induced by a reduction in intraluminal free Ca(2+) concentration ([Ca(2+)](ER))...
  6. Chen P, Gearhart J, Protopopova M, Einck L, Nacy C. Synergistic interactions of SQ109, a new ethylene diamine, with front-line antitubercular drugs in vitro. J Antimicrob Chemother. 2006;58:332-7 pubmed
  7. Ra H, Kim H, Lee H, Kim Y. Essential role of p53 in TPEN-induced neuronal apoptosis. FEBS Lett. 2009;583:1516-20 pubmed publisher
    ..Inhibition of p53 blocked cytochrome C release from mitochondria to cytosol and prevented caspase-3 activation. Therefore, p53 may be an essential regulatory factor for TPEN-induced neuronal apoptosis...
  8. Reddy V, Einck L, Andries K, Nacy C. In vitro interactions between new antitubercular drug candidates SQ109 and TMC207. Antimicrob Agents Chemother. 2010;54:2840-6 pubmed publisher
    ..SQ109 was active by itself, and both its activity was improved by and it improved the in vitro activities of both RIF and TMC207...
  9. Hashemi M, Ghavami S, Eshraghi M, Booy E, Los M. Cytotoxic effects of intra and extracellular zinc chelation on human breast cancer cells. Eur J Pharmacol. 2007;557:9-19 pubmed
    ..Interestingly, addition of Ca(2+), or Mg(2+) had no effect. The antioxidant N-Acetyl-L-Cysteine inhibited the cytotoxic effect of DTPA and TPEN, indicating that oxidative stress is the likely mediator of Zn-deficiency-related cell death...
  10. Jung C, Zima A, Szentesi P, Jona I, Blatter L, Niggli E. Ca2+ release from the sarcoplasmic reticulum activated by the low affinity Ca2+ chelator TPEN in ventricular myocytes. Cell Calcium. 2007;41:187-94 pubmed
    ..This in turn results in an increased Ca2+ leak from the SR leading to its Ca2+ depletion. Lowering of SR Ca2+ content may be a mechanism underlying the recently reported cardioprotective and antiarrhythmic features of TPEN...
  11. Jia L, Coward L, Gorman G, Noker P, Tomaszewski J. Pharmacoproteomic effects of isoniazid, ethambutol, and N-geranyl-N'-(2-adamantyl)ethane-1,2-diamine (SQ109) on Mycobacterium tuberculosis H37Rv. J Pharmacol Exp Ther. 2005;315:905-11 pubmed
    ..The present study identified proteins directly modulated by the actions of INH, EMB, and SQ109 and distinguished INH activity from the diamine antitubercular compounds that inhibit M. tuberculosis H37Rv...
  12. Caroppo R, Colella M, Colasuonno A, DeLuisi A, Debellis L, Curci S, et al. A reassessment of the effects of luminal [Ca2+] on inositol 1,4,5-trisphosphate-induced Ca2+ release from internal stores. J Biol Chem. 2003;278:39503-8 pubmed
    ..These results demonstrate that the filling state of stores modulates the magnitude of InsP3-induced Ca2+release by additional mechanism(s) that are independent of regulation by cytoplasmic [Ca2+] or effects on SERCA pumps...
  13. Kolenko V, Uzzo R, Dulin N, Hauzman E, Bukowski R, Finke J. Mechanism of apoptosis induced by zinc deficiency in peripheral blood T lymphocytes. Apoptosis. 2001;6:419-29 pubmed
    ..The release of cytochrome c and activation of downstream caspases precedes changes in the mitochondrial transmembrane potential (Delta Psim). Therefore, cytoplasmic and mitochondrial events are critical to this process...
  14. Adler M, Shafer H, Hamilton T, Petrali J. Cytotoxic actions of the heavy metal chelator TPEN on NG108-15 neuroblastoma-glioma cells. Neurotoxicology. 1999;20:571-82 pubmed
    ..Addition of an equimolar concentration of Zn2+ or Cu2+ but not Fe2+ or Mn2+ prevented morphological abnormalities and cell death...
  15. Baker K, Marcus C, Huffman K, Kruk H, Malfroy B, Doctrow S. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury. J Pharmacol Exp Ther. 1998;284:215-21 pubmed
    ..Overall, this study suggests that synthetic SOD/catalase mimetics might serve as novel, multifunctional therapeutic agents for stroke...
  16. Corniola R, Tassabehji N, Hare J, Sharma G, Levenson C. Zinc deficiency impairs neuronal precursor cell proliferation and induces apoptosis via p53-mediated mechanisms. Brain Res. 2008;1237:52-61 pubmed publisher
    ..These data suggest that zinc plays a role in neurogenesis by regulating p53-dependent molecular mechanisms that control neuronal precursor cell proliferation and survival...
  17. Kawakami S, Matsuda A, Sunagawa T, Noda Y, Kaneko T, Tahara S, et al. Antioxidant, EUK-8, prevents murine dilated cardiomyopathy. Circ J. 2009;73:2125-34 pubmed
    ..Mice lacking manganese-superoxide dismutase (Mn-SOD) activity exhibit the typical pathology of dilated cardiomyopathy (DCM). In the present study, presymptomatic and symptomatic mutant mice were treated with the SOD/catalase mimetic, EUK-8...
  18. Eberius C, Schild D. Local photolysis using tapered quartz fibres. Pflugers Arch. 2001;443:323-30 pubmed
    ..Site and timing of photolysis can be chosen independently from other experimental parameters. As an application example we show the spatially heterogeneous distribution of Ca2+-dependent Cl- channels in olfactory receptor neurons...
  19. Liu X, Ambudkar I. Characteristics of a store-operated calcium-permeable channel: sarcoendoplasmic reticulum calcium pump function controls channel gating. J Biol Chem. 2001;276:29891-8 pubmed
    ..These novel findings reveal that SERCA plays a major role in the gating of SOCC by (i) refilling the internal Ca(2+) store(s) and (ii) decreasing the [Ca(2+)](i)-dependent inhibition...
  20. Pratt R, Lyons C, Wasinger E, Stack T. Electrochemical and spectroscopic effects of mixed substituents in bis(phenolate)-copper(II) galactose oxidase model complexes. J Am Chem Soc. 2012;134:7367-77 pubmed publisher
    ..Application of the modified Marcus-Hush analysis to GO using parameters determined for [2(R(1),R(2))](+) predicts a ?(max) of ?13600 cm(-1), well within the energy range of the broad Vis-NIR band displayed by the enzyme. ..
  21. Ellison M, Farrow J, Farrow J, Parrish W, Danell A, Pesci E. The transcriptional regulator Np20 is the zinc uptake regulator in Pseudomonas aeruginosa. PLoS ONE. 2013;8:e75389 pubmed publisher
    ..Taken together, these data support the notion that Np20 is the P. aeruginosa Zur, which regulates the transcription of the genes encoding the high affinity ZnuABC zinc transport system...
  22. Seok S, Cho W, Park J, Na Y, Jang A, Kim H, et al. Rat pancreatitis produced by 13-week administration of zinc oxide nanoparticles: biopersistence of nanoparticles and possible solutions. J Appl Toxicol. 2013;33:1089-96 pubmed publisher
    ..These results indicate that the bio-persistence of ZnO NPs after ingestion is key to their toxicity; the no-observed-adverse effect level (NOAEL) of ZnO NPs was found to be 268.4?mg?kg(-1) per day for both sexes. ..
  23. Moon J, Roh D, Yoon S, Kang S, Choi S, Kwon S, et al. Sigma-1 receptor-mediated increase in spinal p38 MAPK phosphorylation leads to the induction of mechanical allodynia in mice and neuropathic rats. Exp Neurol. 2013;247:383-91 pubmed publisher
    ..Sigma-1 receptor modulation of p-p38 MAPK also plays an important role in the induction, but not the maintenance, of MA in neuropathic pain. ..
  24. Das L, Park S, Cho S, Ghosh A. An unprecedented "linear-bent" isomerism in tri-nuclear Cu2(II)Zn(II) complexes with a salen type di-Schiff base ligand. Dalton Trans. 2012;41:11009-17 pubmed publisher
    ..06 kcal mol(-1) higher than that of 1B. The existence of both isomers in the solid state suggests that crystal packing interactions in are more efficient and probably compensate for the difference in energy. ..
  25. Qiu L, Ding X, Zhang Z, Kang Y. Copper is required for cobalt-induced transcriptional activity of hypoxia-inducible factor-1. J Pharmacol Exp Ther. 2012;342:561-7 pubmed publisher
    ..The present study thus demonstrates that copper was required for cobalt-activated transcriptional activity of HIF-1, although copper did not affect cobalt-induced accumulation of HIF-1? in the cells...
  26. Race M. Applicability of alkaline precipitation for the recovery of EDDS spent solution. J Environ Manage. 2017;203:358-363 pubmed publisher
    ..At the same time, they were more biodegradable compared to non-treated solutions, confirming that EDDS-metal chelates may represent a threat for biological wastewater processes. ..
  27. Reid N, Jariwala S, Hudes G, Fodeman J, Jerschow E, Rosenstreich D. Worsening of contact dermatitis by oral hydroxyzine: a case report. Dermatol Online J. 2013;19:4 pubmed
    ..can sometimes be linked to worsening dermatitis in patients who have sensitivities to phenothiazines and/or ethylenediamines. Herein we describe a patient who developed papulovesicular eruptions following the use of topical neomycin...
  28. Aranda P, Lajoie D, Jorcyk C. Bleach gel: a simple agarose gel for analyzing RNA quality. Electrophoresis. 2012;33:366-9 pubmed publisher
    ..Because of this, the 'bleach gel' is a functional approach that addresses the need for an inexpensive and safe way to evaluate RNA integrity and will improve the ability of researchers to rapidly analyze RNA quality. ..
  29. Pappalardo A, Amato M, Ballistreri F, Tomaselli G, Toscano R, Trusso Sfrazzetto G. Pair of diastereomeric uranyl salen cavitands displaying opposite enantiodiscrimination of ?-amino acid ammonium salts. J Org Chem. 2012;77:7684-7 pubmed publisher
    ..Whereas the free ligands show a preference for the same enantiomer of an ?-amino acid pair, the corresponding UO(2) complexes display opposite enantiodiscrimination and exceptionally high enantioselectivities (K(D)/K(L) = 26.4). ..
  30. Hu J, Wu Q, Li W, Ma L, Su F, Guo Y, et al. Epoxidation of alkenes catalyzed by phenyl group-modified, periodic mesoporous organosilica-entrapped, dimeric manganese-salen complexes. ChemSusChem. 2011;4:1813-22 pubmed publisher
    ..Finally, the reusability of the supported dimeric Mn(salen) complexes was evaluated over three catalytic runs. ..
  31. Bahramikia S, Yazdanparast R. Inhibition of human islet amyloid polypeptide or amylin aggregation by two manganese-salen derivatives. Eur J Pharmacol. 2013;707:17-25 pubmed publisher
  32. Yoon H, Lee Y, Wu X, Cho K, Sarangi R, Nam W, et al. Enhanced electron-transfer reactivity of nonheme manganese(IV)-oxo complexes by binding scandium ions. J Am Chem Soc. 2013;135:9186-94 pubmed publisher
  33. Corona Martínez D, Gómez Tagle P, Yatsimirsky A. Electrophilic assistance to the cleavage of an RNA model phopshodiester via specific and general base-catalyzed mechanisms. J Org Chem. 2012;77:9110-9 pubmed publisher
    ..It appears from results of this study that Mg(2+) is unique in its ability to assist efficiently the general base-catalyzed transesterification often occurring in active sites of nuclease enzymes and ribozymes. ..
  34. Fundueanu G, Constantin M, Oanea I, Harabagiu V, Ascenzi P, Simionescu B. Prediction of the appropriate size of drug molecules that could be released by a pulsatile mechanism from pH/thermoresponsive microspheres obtained from preformed polymers. Acta Biomater. 2012;8:1281-9 pubmed publisher
  35. Rodríguez Muñoz M, de la Torre Madrid E, Sánchez Blázquez P, Garzón J. NO-released zinc supports the simultaneous binding of Raf-1 and PKC? cysteine-rich domains to HINT1 protein at the mu-opioid receptor. Antioxid Redox Signal. 2011;14:2413-25 pubmed publisher
    ..This study reveals new aspects of ERK1/2 regulation by the MOR without requiring the transactivation of a receptor tyrosine kinase. ..
  36. Wallis R, Jakubiec W, Mitton Fry M, Ladutko L, Campbell S, Paige D, et al. Rapid evaluation in whole blood culture of regimens for XDR-TB containing PNU-100480 (sutezolid), TMC207, PA-824, SQ109, and pyrazinamide. PLoS ONE. 2012;7:e30479 pubmed publisher
    ..Further testing of regimens including these compounds is warranted. Measurement of whole blood bactericidal activity can accelerate the development of novel TB regimens. ..
  37. Li Z, Xue Z, Wu Z, Han J, Han S. Chromo-fluorogenic detection of aldehydes with a rhodamine based sensor featuring an intramolecular deoxylactam. Org Biomol Chem. 2011;9:7652-4 pubmed publisher
    ..The utility of the sensor was demonstrated by fluorescent labeling of aldehyde-displaying sialoproteins on cell surfaces. ..
  38. Sathiyaraj E, Thirumaran S. Synthesis and spectral studies on Pb(II) dithiocarbamate complexes containing benzyl and furfuryl groups and their use as precursors for PbS nanoparticles. Spectrochim Acta A Mol Biomol Spectrosc. 2012;97:575-81 pubmed publisher
    ..The PXRD measurements suggest that PbS nanoparticles are single phase with face-centered-cubic structure. ..
  39. Silva A, Adade C, Shoyama F, Neto C, Padrón T, De Almeida M, et al. In vitro leishmanicidal activity of N-dodecyl-1,2-ethanediamine. Biomed Pharmacother. 2012;66:180-6 pubmed publisher
  40. Tahlan K, Wilson R, Kastrinsky D, Arora K, Nair V, Fischer E, et al. SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2012;56:1797-809 pubmed publisher
    ..Our results suggest that MmpL3 is the target of SQ109 and that MmpL3 is a transporter of mycobacterial TMM. ..
  41. van der Aa L, Vader P, Storm G, Schiffelers R, Engbersen J. Optimization of poly(amido amine)s as vectors for siRNA delivery. J Control Release. 2011;150:177-86 pubmed publisher
    ..Copolymers with 20% EDA showed excellent gene silencing properties in vitro (70% luciferase knockdown in H1299 cells) with negligible cytotoxicity. ..
  42. Yan L, Li C, Zhang J, Moodley O, Liu S, Lan C, et al. Enhanced Phytoextraction of Lead from Artificially Contaminated Soil by Mirabilis jalapa with Chelating Agents. Bull Environ Contam Toxicol. 2017;99:208-212 pubmed publisher
    ..Given the potential environmental risks of EDTA, we recommend NTA be used as a suitable chelating agent to increase the phytoremediation of Pb-contaminated soil with M. jalapa. ..
  43. Lopes R, Reyes R, Romero González R, Frenich A, Vidal J. Development and validation of a multiclass method for the determination of veterinary drug residues in chicken by ultra high performance liquid chromatography-tandem mass spectrometry. Talanta. 2012;89:201-8 pubmed publisher
    ..1 ?g kg(-1) (mebendazole) to 423.6 ?g kg(-1) (flumequine). Finally, the method was applied to real samples and traces of some compounds were found in eight samples of chicken and benzathine was detected in one sample at 29.9 ?g kg(-1). ..
  44. Brun E, Puchades R, Maquieira A. Gold, carbon, and aluminum low-reflectivity compact discs as microassaying platforms. Anal Chem. 2013;85:4178-86 pubmed publisher
    ..The results show the possibility of doing assays on this new supports with good analytical performances while maintaining discs' optical and mechanical properties to be read by a CD player. ..
  45. Brown L, Seaton K, Mohseni R, Vasiliev A. Immobilization of heavy metals on pillared montmorillonite with a grafted chelate ligand. J Hazard Mater. 2013;261:181-7 pubmed publisher
    ..As a result, the adsorbent can be used for reduction of heavy metal leaching from contaminated sites. ..
  46. Zhuo F, Xie W, Yang Y, Zhang L, Wang P, Yuan R, et al. TMEDA-assisted effective direct ortho arylation of electron-deficient N-heteroarenes with aromatic Grignard reagents. J Org Chem. 2013;78:3243-9 pubmed publisher
  47. Jin Z, Sha W, Zhang Y, Zhao J, Ji H. Isolation of Burkholderia cepacia JB12 from lead- and cadmium-contaminated soil and its potential in promoting phytoremediation with tall fescue and red clover. Can J Microbiol. 2013;59:449-55 pubmed publisher
    ..The potential for viable phytoremediation of lead- and cadmium-polluted soils with tall fescue and red clover combined with JB12 was further enhanced by the addition of EDDS. ..
  48. Narawane S, Budnjo A, Grauffel C, Haug B, Reuter N. In silico design, synthesis, and assays of specific substrates for proteinase 3: influence of fluorogenic and charged groups. J Med Chem. 2014;57:1111-5 pubmed publisher
    ..Using in silico design followed by enzymatic assays, we show that Abz and EDDnp significantly contribute to substrate hydrolysis by PR3. We also propose a new substrate specific for PR3. ..
  49. Enyedy Ã, Mészáros J, Dömötör O, Hackl C, Roller A, Keppler B, et al. Comparative solution equilibrium studies on pentamethylcyclopentadienyl rhodium complexes of 2,2'-bipyridine and ethylenediamine and their interaction with human serum albumin. J Inorg Biochem. 2015;152:93-103 pubmed publisher
    ..In the case of the deferiprone complex, the RhCp* fragment is cleaved off when HSA is loaded with low equivalents of the compound. ..
  50. Pitarresi G, Fiorica C, Licciardi M, Palumbo F, Giammona G. New hyaluronic acid based brush copolymers synthesized by atom transfer radical polymerization. Carbohydr Polym. 2013;92:1054-63 pubmed publisher
  51. Chen J, Zhang Y, Lou X. One-pot synthesis of uniform Fe?O? nanospheres with carbon matrix support for improved lithium storage capabilities. ACS Appl Mater Interfaces. 2011;3:3276-9 pubmed publisher
    ..However, the carbon-free counterpart can only deliver a much lower capacity of 328 mA h g(-1). ..
  52. Dudkin V, Rickert K, Kreatsoulas C, Wang C, Arrington K, Fraley M, et al. Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates. Bioorg Med Chem Lett. 2012;22:2609-12 pubmed publisher
  53. Zhang Y, Pan S, Shen H, Hu M. Amino-functionalized nano-size composite materials for dispersive solid-phase extraction of phosphate in water samples. Anal Sci. 2012;28:887-92 pubmed
    ..The present method was successfully applied to the determination of phosphate at trace levels in real water samples, and it was confirmed that the TEPA-NCMs are highly effective dSPE materials...
  54. Flor S, Lucangioli S, Contin M, Tripodi V. Simultaneous determination of nine endogenous steroids in human urine by polymeric-mixed micelle capillary electrophoresis. Electrophoresis. 2010;31:3305-13 pubmed publisher
    ..The recoveries ranged between 82.4 and 101.5%. Due to its simplicity, speed, accuracy and reliability, the proposed method could be a potential alternative to the traditional methodologies used with clinical purposes...
  55. Bhutada P, Mundhada Y, Ghodki Y, Chaware P, Dixit P, Jain K, et al. Influence of sigma-1 receptor modulators on ethanol-induced conditioned place preference in the extinction-reinstatement model. Behav Pharmacol. 2012;23:25-33 pubmed publisher
    ..The results add to the growing literature on sigma-1 receptor modulation in the pharmacotherapy of ethanol addiction...
  56. Hu Q, Zhou B, Ye Y, Jiang Z, Huang X, Li Y, et al. Cytotoxic deoxybenzoins and diphenylethylenes from Arundina graminifolia. J Nat Prod. 2013;76:1854-9 pubmed publisher
    ..Compounds 1-11 were evaluated for cytotoxicity against five human tumor cell lines. Compounds 4, 5, and 9-11 showed significant cytotoxicity against five cancer cell lines, with IC50 values ranging from 1.8 to 8.7 ?M. ..
  57. Mendil D, Bardak H, Tuzen M, Soylak M. Selective speciation of inorganic antimony on tetraethylenepentamine bonded silica gel column and its determination by graphite furnace atomic absorption spectrometry. Talanta. 2013;107:162-6 pubmed publisher
    ..Total antimony was determined in refined salt, unrefined salt, black tea, rice, tuna fish and soil samples after microwave digestion and presented enrichment method combination...
  58. Zhang Q, Wilson P, Li Z, McHale R, Godfrey J, Anastasaki A, et al. Aqueous copper-mediated living polymerization: exploiting rapid disproportionation of CuBr with Me6TREN. J Am Chem Soc. 2013;135:7355-63 pubmed publisher
    ..Finally, this robust technique was applied to polymerizations under biologically relevant conditions (PBS buffer) and a complex ethanol/water mixture (tequila)...
  59. Thomé I, Bolm C. Transition-metal-free intramolecular N-arylations. Org Lett. 2012;14:1892-5 pubmed publisher
    ..In the presence of a mixture of 10 mol % of N,N'-dimethylethylenediamine (DMEDA) and 2 equiv of K(2)CO(3) in toluene at 135 °C the products are obtained in high yields...
  60. Lo I, Tsang D, Yip T, Wang F, Zhang W. Influence of injection conditions on EDDS-flushing of metal-contaminated soil. J Hazard Mater. 2011;192:667-75 pubmed publisher
    ..These results suggest a slower and continuous injection for the best Ni or Cu removal, but a faster and step-gradient injection for Zn or Pb removal...
  61. Fuentes M, Ortuño M, Pérez Sarmiento F, Bacaicoa E, Baigorri R, Conejero W, et al. Efficiency of a new strategy involving a new class of natural hetero-ligand iron(III) chelates (Fe(III)-NHL) to improve fruit tree growth in alkaline/calcareous soils. J Sci Food Agric. 2012;92:3065-71 pubmed publisher
    ..These chelates involve the participation in the reaction system of a partially humified lignin-based natural polymer and citric acid...
  62. Ross A, Dreiocker F, Schäfer M, Oomens J, Meijer A, Pickup B, et al. Evidence for the role of tetramethylethylenediamine in aqueous Negishi cross-coupling: synthesis of nonproteinogenic phenylalanine derivatives on water. J Org Chem. 2011;76:1727-34 pubmed publisher
    ..In all cases, the product 5 of reductive dimerization of the iodide 1 is also isolated...
  63. Matias A, Manieri T, Cerchiaro G. Zinc Chelation Mediates the Lysosomal Disruption without Intracellular ROS Generation. Oxid Med Cell Longev. 2016;2016:6724585 pubmed publisher
    ..As a result, we suggest that TPEN causes intracellular zinc depletion which can influence the breakdown of lysosomes and cell death without ROS generation. ..
  64. Li P, Liu H, Yang L, Liu J. Sensitive and selective SERS probe for Hg(II) detection using aminated ring-close structure of Rhodamine6G. Talanta. 2013;106:381-7 pubmed publisher
  65. Faas G, Mody I. Measuring the kinetics of calcium binding proteins with flash photolysis. Biochim Biophys Acta. 2012;1820:1195-204 pubmed publisher
    ..The CBPs compete for Ca2+ which plays a direct role in modulating Ca2+ transients and the resulting biochemical message. The kinetic properties of the CBPs have to be known to have a good understanding of Ca2+ signaling...
  66. Jeslin Kanaga Inba P, Annaraj B, Thalamuthu S, Neelakantan M. Salen, reduced salen and N-alkylated salen type compounds: spectral characterization, theoretical investigation and biological studies. Spectrochim Acta A Mol Biomol Spectrosc. 2013;104:300-9 pubmed publisher
    ..The N-alkylated compound has a higher DPPH free radical scavenging activity. The antimicrobial activity was investigated on various gram positive and gram negative bacteria...
  67. Kwon S, Roh D, Yoon S, Choi S, Choi H, Moon J, et al. Role of peripheral sigma-1 receptors in ischaemic pain: Potential interactions with ASIC and P2X receptors. Eur J Pain. 2016;20:594-606 pubmed publisher
    ..Peripheral Sig-1Rs contribute to the induction of ischaemia-induced MA via facilitation of ASICs and P2X receptors. Thus, peripheral Sig-1Rs represent a novel therapeutic target for the treatment of ischaemic pain. ..
  68. Sajan P, Jayasree R, Agouram S, Bushiri M. Synthesis of cubic ZnS microspheres exhibiting broad visible emission for bioimaging applications. Luminescence. 2016;31:544-50 pubmed publisher
    ..ZnS microspheres, along with biological cell lines, were giving visible light emission and could be used for bioimaging applications...
  69. Ma H, Forssell P, Partanen R, Buchert J, Boer H. Charge modifications to improve the emulsifying properties of whey protein isolate. J Agric Food Chem. 2011;59:13246-53 pubmed publisher
    ..As compared with the unmodified whey proteins, the modified ones were proven to cover the interface more efficiently with extensive surface charge at pH 5, although the interfacial layer was less resistant to the surfactant displacement...
  70. Feng S, Zhang M, Huang Y, Yuan D, Zhu Y. Simultaneous determination of nanomolar nitrite and nitrate in seawater using reverse flow injection analysis coupled with a long path length liquid waveguide capillary cell. Talanta. 2013;117:456-62 pubmed publisher
    ..Compared to normal flow injection analysis, the rFIA method is superior due to its lower reagent consumption, less dispersion of sample, as well as higher sensitivity...
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    ..The pyrene fluorescence and dynamic light scattering results revealed that the micelle size depends on the longer of the two alkyl chains in dissymmetric surfactants. ..
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    ..These findings regarding the capability of EDDS/goethite system to promote heterogeneous photo-Fenton oxidation have important practical implications for water treatment technologies...
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    ..Therefore, the pseudopeptidic cages sharing the same binding motif for chloride rendered very different interaction and transport properties depending on the peripheral substitution...
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    ..Moreover, the possible toxic effect of the chelate photodegradation products, elsewhere proposed, on soybean growth has been tested...
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    ..The catalyst 1 was successfully recycled for a number of times. ..
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    ..This means that the newly developed gel has the potential to measure K and plant-available P in soils simultaneously...
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    ..The latter can also be thought of as an ion pair formed from an alkali metal anion (M(-)) and solvated cation (M(en)(3)(+))...
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    ..54 for 1 and 0.72?h(-1) for 2. The nuclease activities of 1 and 2 are significant, giving rise to (2.03-2.88)×10(7) -fold rate enhancement compared to non-catalyzed DNA cleavage...
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    ..The present topographical study revealed reactive Zn throughout the CNS in adult zebrafish that should be considered in future investigation of Zn in the brain on a larger scale...
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    ..7 mg/g with a purity of 93.8%. It was observed that cytochrome c could be repeatedly adsorbed and eluted with the PHEMAH cryogel without significant loss in the adsorption capacity...
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    ..Moreover, the CFS appears to more reliably uncover a ?(1) pharmacological component in antidepressant screening...
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    ..The potential transfer of cephapirin from cows treated on-label at dry off to calves via colostrum may not be a significant source of cephapirin residues in veal tissues...