diamines

Summary

Summary: Organic chemicals which have two amino groups in an aliphatic chain.

Top Publications

  1. Bandyopadhyay D, Mukherjee S, Rodriguez R, Banik B. An effective microwave-induced iodine-catalyzed method for the synthesis of quinoxalines via condensation of 1,2-diamines with 1,2-dicarbonyl compounds. Molecules. 2010;15:4207-12 pubmed publisher
    A microwave-induced iodine-catalyzed simple, rapid and convenient synthesis of different types of quinoxalines via condensation of 1,2-diamines with 1,2-dicarbonyl compounds has been accomplished with an excellent yield.
  2. Martin J, Garcia Estrada C, Kosalkova K, Ullan R, Albillos S, Martín J. The inducers 1,3-diaminopropane and spermidine produce a drastic increase in the expression of the penicillin biosynthetic genes for prolonged time, mediated by the laeA regulator. Fungal Genet Biol. 2012;49:1004-13 pubmed publisher
  3. Caminos A, Panozzo Zénere E, Wilkinson S, Tekwani B, Labadie G. Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines. Bioorg Med Chem Lett. 2012;22:1712-5 pubmed publisher
    A series of 25 N,N'-substituted diamines were prepared by controlled reductive amination of free aliphatic diamines with different substituted benzaldehydes...
  4. Clifford Nunn B, Showalter H, Andrews P. Quaternary diamines as mass spectrometry cleavable crosslinkers for protein interactions. J Am Soc Mass Spectrom. 2012;23:201-12 pubmed publisher
    ..The DC4 crosslinking reagent is stable to storage, highly reactive, highly soluble (1 M solutions), quite labile to CID, and MS(3) results in productive backbone fragmentation...
  5. Pinheiro A, Rocha M, Nogueira P, Nogueira T, Jasmim L, De Souza M, et al. Synthesis, cytotoxicity, and in vitro antileishmanial activity of mono-t-butyloxycarbonyl-protected diamines. Diagn Microbiol Infect Dis. 2011;71:273-8 pubmed publisher
    ..A higher lipophilicity is likely to improve the chances of reaching this intracellular parasite...
  6. Kagliwal L, Survase S, Singhal R. A novel medium for the production of cephamycin C by Nocardia lactamdurans using solid-state fermentation. Bioresour Technol. 2009;100:2600-6 pubmed publisher
    ..75+/-0.27 mg/gds of cephamycin C as compared to 8.37+/-0.23 mg/gds before optimization. Effect of 1,3-diaminopropane on cephamycin C production was further studied, which further increased the yield to 27.64+/-0.33 mg/gds...
  7. Gastaminza P, Pitram S, Dreux M, Krasnova L, Whitten Bauer C, Dong J, et al. Antiviral stilbene 1,2-diamines prevent initiation of hepatitis C virus RNA replication at the outset of infection. J Virol. 2011;85:5513-23 pubmed publisher
    ..assay to interrogate a 1,200-compound chemical library for anti-HCV activity, we identified a family of 1,2-diamines derived from trans-stilbene oxide that prevent HCV infection at nontoxic, low micromolar concentrations in cell ..
  8. Chouyyok W, Shin Y, Davidson J, Samuels W, LaFemina N, Rutledge R, et al. Selective removal of copper(II) from natural waters by nanoporous sorbents functionalized with chelating diamines. Environ Sci Technol. 2010;44:6390-5 pubmed publisher
    ..g., Ca(2+), Fe(2+), Ni(2+), and Zn(2+)) and was able to achieve Cu below the EPA recommended levels for river and sea waters...
  9. Therrien E, Larouche G, Manku S, Allan M, Nguyen N, Styhler S, et al. 1,2-Diamines as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1). Bioorg Med Chem Lett. 2009;19:6725-32 pubmed publisher
    ..The potency of these inhibitors is in the same order of magnitude as their predecessors and their clearance, volume of distribution, and half lives were greatly improved...

More Information

Publications77

  1. Sen A, Sahu D, Ganguly B. In silico studies toward understanding the interactions of DNA base pairs with protonated linear/cyclic diamines. J Phys Chem B. 2013;117:9840-50 pubmed publisher
    ..we have performed DFT calculations on the interactions of some simple cyclic and constrained protonated diamines with the DNA base pairs and compared the results with those obtained for the corresponding interactions involving ..
  2. Giordani R, De Almeida M, Fernandes E, França da Costa C, De Carli G, Tasca T, et al. Anti-Trichomonas vaginalis activity of synthetic lipophilic diamine and amino alcohol derivatives. Biomed Pharmacother. 2009;63:613-7 pubmed publisher
    ..We report in this work the preparation and the in vitro anti-trichomonads activity of two diamines 1 and 2, and three different lipophilic amino alcohol derivatives 3, 4 and 5...
  3. Kendra P, Epsky N, Montgomery W, Heath R. Response of Anastrepha suspensa (Diptera: Tephritidae) to terminal diamines in a food-based synthetic attractant. Environ Entomol. 2008;37:1119-25 pubmed
    ..response of the Caribbean fruit fly, Anastrepha suspensa (Loew), to putrescine and four homologous terminal diamines, differing only in carbon chain length...
  4. Bregier Jarzebowska R, Gasowska A, Jastrzab R, Lomozik L. Noncovalent interactions and coordination reactions in the systems consisting of copper(II) ions, aspartic acid and diamines. J Inorg Biochem. 2009;103:1228-35 pubmed publisher
    ..In the adducts the protonated diamine is in the outer coordination sphere and is involved in noncovalent interactions with the anchoring CuH(Asp) or Cu(Asp) complexes...
  5. Malagu K, Duggan H, Menear K, Hummersone M, Gomez S, Bailey C, et al. The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase. Bioorg Med Chem Lett. 2009;19:5950-3 pubmed publisher
    ..The compounds display good selectivity relative to other PI3K-related kinase family members and, in cellular assays, inhibit both mTORC1 and mTORC2 complexes and exhibit good antiproliferative activity...
  6. Júnior C, Le Hyaric M, Costa C, Corrêa T, Taveira A, Araújo D, et al. Preparation and antitubercular activity of lipophilic diamines and amino alcohols. Mem Inst Oswaldo Cruz. 2009;104:703-5 pubmed
    A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity...
  7. Júnior C, Alves R, Rezende C, da Costa C, Silva H, Le Hyaric M, et al. Trypanocidal activity of lipophilic diamines and amino alcohols. Biomed Pharmacother. 2010;64:624-6 pubmed publisher
    Trypanocidal activity of a number of lipophilic diamines and amino alcohols was evaluated in vitro against Trypanosoma cruzi blood stream forms. Several of the studied compounds showed inhibition of T. cruzi growth...
  8. Mazzoccoli L, Cadoso S, Amarante G, De Souza M, Domingues R, Machado M, et al. Novel thalidomide analogues from diamines inhibit pro-inflammatory cytokine production and CD80 expression while enhancing IL-10. Biomed Pharmacother. 2012;66:323-9 pubmed publisher
    ..Our results indicate that the novel diamine compounds 3, 6 and 9 inhibit critical pro-inflammatory cytokines and stimulate IL-10, which make them attractive candidate drugs for the treatment of certain inflammatory conditions and cancer...
  9. Giordani R, Araújo D, Duarte M, Zuanazzi J, Tasca T, de Almeida M. Anti-protozoal activity of diamine derivatives. Biomed Pharmacother. 2011;65:60-2 pubmed publisher
    Ten N-monoalkylated diamines were synthesized and evaluated for in vitro activities against Trichomonas vaginalis and Giardia lamblia. Several compounds displayed a good inhibition of parasite growth, with MIC less or equal to 20?g/mL...
  10. Kessler A, Faure H, Petrel C, Ruat M, Dauban P, Dodd R. N2-benzyl-N1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1,2-diamines and conformationally restrained indole analogues: development of calindol as a new calcimimetic acting at the calcium sensing receptor. Bioorg Med Chem Lett. 2004;14:3345-9 pubmed
    ..0+/-0.1 or 0.31+/-0.05 microM in cells expressing the rat or the human CaSR, respectively. The calcimimetic activities of these novel compounds were shown to be due to a specific interaction with the CaSR...
  11. Del Olmo E, Plaza A, Muro A, Martínez Fernández A, Nogal Ruiz J, López Pérez J, et al. Synthesis and evaluation of some lipidic aminoalcohols and diamines as immunomodulators. Bioorg Med Chem Lett. 2006;16:6091-5 pubmed
    Lymphoproliferation inhibition and cytotoxicity of a number of lipidic aminoacids, aminoalcohols and diamines were evaluated as a preliminary screening to select potential immunomodulators...
  12. Lee R, Protopopova M, Crooks E, Slayden R, Terrot M, Barry C. Combinatorial lead optimization of [1,2]-diamines based on ethambutol as potential antituberculosis preclinical candidates. J Comb Chem. 2003;5:172-87 pubmed
    ..N-Geranyl-N'-(2-adamantyl)ethane-1,2-diamine (109), the most active of these diamines, displayed a 14-35-fold improvement in activity in vitro against Mycobacterium tuberculosis, as compared to EMB.
  13. Li X, Tanasova M, Vasileiou C, Borhan B. Fluorinated porphyrin tweezer: a powerful reporter of absolute configuration for erythro and threo diols, amino alcohols, and diamines. J Am Chem Soc. 2008;130:1885-93 pubmed publisher
    ..nonempirical protocol to determine the absolute configurations of erythro and threo diols, amino alcohols, and diamines is reported...
  14. Khim S, Bauman J, Evans J, Freeman B, King B, Kirkland T, et al. Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors. Bioorg Med Chem Lett. 2008;18:3895-8 pubmed publisher
    The synthesis and biological evaluation of a series of aryl diamines as inhibitors of LTA(4)-h inhibitors are described...
  15. Kamio Y. Structural specificity of diamines covalently linked to peptidoglycan for cell growth of Veillonella alcalescens and Selenomonas ruminantium. J Bacteriol. 1987;169:4837-40 pubmed
    ..specificity of the diamine requirement for normal cell growth of these bacteria was examined by using a series of diamines with a general structure of NH3+ X (CH2)n X NH3+...
  16. Momo F, Fabris S, Stevanato R. Interaction of linear mono- and diamines with dimyristoylphosphatidylcholine and dimyristoylphosphatidylglycerol multilamellar liposomes. Arch Biochem Biophys. 2000;382:224-31 pubmed
    ..The study was extended to linear alpha,omega-diamines to investigate the amphipathic character of long diamines and to investigate the role of bridging bonds ..
  17. Burns M, LaTurner S, Ziemer J, McVean M, Devens B, Carlson C, et al. Induction of apoptosis by aryl-substituted diamines: role of aromatic group substituents and distance between nitrogens. Bioorg Med Chem Lett. 2002;12:1263-7 pubmed
    A series of aromatic substituted diamines was synthesized and characterized for their cytotoxic profiles against human breast and prostate tumor cell lines...
  18. Labadie G, Choi S, Avery M. Diamine derivatives with antiparasitic activities. Bioorg Med Chem Lett. 2004;14:615-9 pubmed
    ..In the present study, different libraries of substituted diamines totalling 78 compounds have been synthesized on solid support and their activities against malaria and leishmania ..
  19. Giordanetto F, Karlsson O, Lindberg J, Larsson L, Linusson A, Evertsson E, et al. Discovery of cyclopentane- and cyclohexane-trans-1,3-diamines as potent melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett. 2007;17:4232-41 pubmed
  20. Higashi K, Yoshida K, Nishimura K, Momiyama E, Kashiwagi K, Matsufuji S, et al. Structural and functional relationship among diamines in terms of inhibition of cell growth. J Biochem. 2004;136:533-9 pubmed
    ..1998) J. Biol. Chem. 273, 15313-15316], we examined the effects of 16 different diamines on cell growth...
  21. Sebela M, Frebort I, Lemr K, Brauner F, Pec P. A study on the reactions of plant copper amine oxidase with C3 and C4 aliphatic diamines. Arch Biochem Biophys. 2000;384:88-99 pubmed
    ..reports a study on the reactions of grass pea (Lathyrus sativus) amine oxidase (GPAO) with several aliphatic diamines. The influence of the chain length and of unsaturations in the molecules was examined...
  22. Varoli L, Andreani A, Burnelli S, Granaiola M, Leoni A, Locatelli A, et al. Diphenidol-related diamines as novel muscarinic M4 receptor antagonists. Bioorg Med Chem Lett. 2008;18:2972-6 pubmed publisher
    ..Taken together, these data suggest that 8b might open new avenues to the discovery of novel multivalent antagonists for the muscarinic receptors...
  23. Demain A, Vaishnav P. Involvement of nitrogen-containing compounds in beta-lactam biosynthesis and its control. Crit Rev Biotechnol. 2006;26:67-82 pubmed
    ..Surprisingly, diamines such as diaminopropane, putrescine and cadaverine induce cephamycin production by actinomycetes...
  24. Kiviranta P, Leppänen J, Kyrylenko S, Salo H, Lahtela Kakkonen M, Tervo A, et al. N,N'-Bisbenzylidenebenzene-1,4-diamines and N,N'-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors. J Med Chem. 2006;49:7907-11 pubmed
    ..The most potent compound was N,N'-bis(2-hydroxybenzylidene)benzene-1,4-diamine, which was equipotent with the most potent hit compound and well-known SIRT2 inhibitor sirtinol...
  25. Wess J, Angeli P, Melchiorre C, Moser U, Mutschler E, Lambrecht G. Methoctramine selectively blocks cardiac muscarinic M2 receptors in vivo. Naunyn Schmiedebergs Arch Pharmacol. 1988;338:246-9 pubmed
    ..This in vivo study thus provides further evidence to support the view that methoctramine is a potent and highly selective antagonist of cardiac M2 alpha receptors...
  26. Mellor I, Ogilvie J, Pluteanu F, Clothier R, Parker T, Rosini M, et al. Methoctramine analogues inhibit responses to capsaicin and protons in rat dorsal root ganglion neurons. Eur J Pharmacol. 2004;505:37-50 pubmed
    ..Similar data were obtained with adult rat dorsal root ganglion neurons. These data indicate that methoctramine analogues bind to vanilloid receptors to inhibit their function...
  27. Gasowska B, Kafarski P, Wojtasek H. Interaction of mushroom tyrosinase with aromatic amines, o-diamines and o-aminophenols. Biochim Biophys Acta. 2004;1673:170-7 pubmed
    ..These results show that the relative positioning of the amino group and the hydroxy group in o-aminophenols with respect to the side chain is important both for binding to the dicopper center and for catalysis...
  28. de Almeida M, Le Hyaric M, Amarante G, Silva Lourenço M, Lima Brandão M. Synthesis of amphiphilic galactopyranosyl diamines and amino alcohols as antitubercular agents. Eur J Med Chem. 2007;42:1076-83 pubmed
    ..Monoacylated derivatives displayed antitubercular activity...
  29. Bunnelle W, Daanen J, Ryther K, Schrimpf M, Dart M, Gelain A, et al. Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors. J Med Chem. 2007;50:3627-44 pubmed
    ..Several N-(3-pyridinyl) derivatives of bridged bicyclic diamines exhibit double-digit-picomolar binding affinities for the alpha 4 beta 2 subtype, placing them with epibatidine ..
  30. Kopecky D, Hao X, Chen Y, Fu J, Jiao X, Jaen J, et al. Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors. Bioorg Med Chem Lett. 2008;18:6352-6 pubmed publisher
    A new series of pyrazolo[3,4-d]pyrimidine-3,6-diamines was designed and synthesized as potent and selective inhibitors of the nonreceptor tyrosine kinase, ACK1...
  31. Li X, Huang M, Duan W, Yang Y. Novel multifunctional polymers from aromatic diamines by oxidative polymerizations. Chem Rev. 2002;102:2925-3030 pubmed
  32. da Costa C, Coimbra E, Braga F, Dos Reis R, Da Silva A, De Almeida M. Preparation and antileishmanial activity of lipophilic N-alkyl diamines. Biomed Pharmacother. 2009;63:40-2 pubmed publisher
    ..in this work the preparation and the in vitro antileishmanial activity of a series of long chains N-monoalkylated diamines and two pyridinediamine derivatives...
  33. Tiwari V, Tewari N, Katiyar D, Tripathi R, Arora K, Gupta S, et al. Synthesis and antifilarial evaluation of N1,Nn- xylofuranosylated diaminoalkanes. Bioorg Med Chem. 2003;11:1789-800 pubmed
    ..Compounds 6, 16 and 17 were evaluated also for in vivo activity...
  34. Young T, Hung C. Change in electrophoretic mobility of PC12 cells after culturing on PVA membranes modified with different diamines. J Biomed Mater Res A. 2003;67:1238-44 pubmed
    ..PC12) cells after they were cultured on the poly (vinyl alcohol) membranes modified with different diamines. Variations in cellular activity and electrophoretic mobility of cultured cells were compared...
  35. Del Olmo E, Alves M, Lopez J, Inchaustti A, Yaluff G, Rojas de Arias A, et al. Leishmanicidal activity of some aliphatic diamines and amino-alcohols. Bioorg Med Chem Lett. 2002;12:659-62 pubmed
    A number of aliphatic diamines and amino-alcohols and several of their alkyl, acyl and carbamoyl derivatives, have been synthesised and evaluated in vitro on cultures of Leishmania spp...
  36. Li F, Zhao G, Wu H, Lin H, Wu X, Zhu S, et al. Synthesis, characterization and biological activity of lanthanum(III) complexes containing 2-methylene-1,10-phenanthroline units bridged by aliphatic diamines. J Inorg Biochem. 2006;100:36-43 pubmed
    Two novel lanthanum(III) complexes containing 2-methylene-1,10-phenanthroline units bridged by aliphatic diamines were synthesized and characterized by elemental analysis, IR, NMR, thermal analysis and conductance measurements...
  37. Dibenedetto A, Pastore C, Fragale C, Aresta M. Hybrid materials for CO2 uptake from simulated flue gases: xerogels containing diamines. ChemSusChem. 2008;1:742-5 pubmed publisher
  38. Olson D, Du Bois J. Catalytic C-H amination for the preparation of substituted 1,2-diamines. J Am Chem Soc. 2008;130:11248-9 pubmed publisher
    ..This highly chemo- and diastereoselective transformation underscores the power of catalytic C-H functionalization as a general approach to C-N bond construction...
  39. Coulibaly W, Paquin L, Bénie A, Bekro Y, Durieu E, Meijer L, et al. Synthesis of N,N'-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines bearing various linkers and biological evaluation as potential inhibitors of kinases. Eur J Med Chem. 2012;58:581-90 pubmed publisher
    The synthesis in 4 steps of new N,N'-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines issued from various symmetric primary diamines as linkers was reported...
  40. Li Y, Qin S, Guo Y, Gu Y, van Soest R. 9'-Epi-3?,3'?-dimethylxestospongin C, a new macrocyclic diamine alkaloid from the Hainan sponge Neopetrosia exigua. Planta Med. 2011;77:179-81 pubmed publisher
    ..A new BIS-1-oxaquinolizidine alkaloid, 9'- EPI-3 ?,3' ?-dimethylxestospongin C (2), and three known related analogues have been isolated from the Hainan sponge Neopetrosia exigua. ..
  41. Abdel Azeem S, Bader N, Kuss H, El Shahat M. Determination of total iron in food samples after flow injection preconcentration on polyurethane foam functionalized with N,N-bis(salicylidene)-1,3-propanediamine. Food Chem. 2013;138:1641-7 pubmed publisher
    ..The precision (RSD) was found to be 5.7% and 3.1% at concentration levels 0.1 and 5.0 ?g mL(-1) iron (II), respectively. Finally, the method was successfully applied to determination of total iron in reference material and food samples. ..
  42. Chen H, Di Tommaso D, Hogarth G, Catlow C. trans-Fe(II)(H)2(diphosphine)(diamine) complexes as alternative catalysts for the asymmetric hydrogenation of ketones? A DFT study. Dalton Trans. 2011;40:402-12 pubmed publisher
    ..Thus the high enantiomeric excess in the hydrogenation of acetophenone could, in principle, be achieved using Fe catalysts. ..
  43. Pichler V, Göschl S, Meier S, Roller A, Jakupec M, Galanski M, et al. Bulky N(,N)-(di)alkylethane-1,2-diamineplatinum(II) compounds as precursors for generating unsymmetrically substituted platinum(IV) complexes. Inorg Chem. 2013;52:8151-62 pubmed publisher
  44. Aki C, Chao J, Ferreira J, Dwyer M, Yu Y, Chao J, et al. Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region. Bioorg Med Chem Lett. 2009;19:4446-9 pubmed publisher
  45. Lerchner A, Jarasch A, Skerra A. Engineering of alanine dehydrogenase from Bacillus subtilis for novel cofactor specificity. Biotechnol Appl Biochem. 2016;63:616-624 pubmed publisher
    ..was applied in a coupled oxidation/transamination reaction of the chiral dicyclic dialcohol isosorbide to its diamines, catalyzed by Ralstonia sp...
  46. Zhang F, Liu Z, Liu J. Asymmetric aza-Henry reaction of chiral fluoroalkyl ?,?-unsaturated N-tert-butanesulfinyl ketoimines: an efficient approach to enantiopure fluoroalkylated ?,?-diamines and ?,?-diamino acids. Org Biomol Chem. 2011;9:3625-8 pubmed publisher
    ..2 equivalent of anhydrous potassium carbonate to give the corresponding adducts diastereoselectively in high yields. Transformations which highlighted the synthetic potential of these aza-Henry adducts were also performed. ..
  47. Pippig F, Holländer A. Hydrogel nanofilms for biomedical applications: synthesis via polycondensation reactions. Macromol Biosci. 2010;10:1093-105 pubmed publisher
    ..PEG diamines were used as branch molecules in the network which were linked by either a trifunctional epoxide or a ..
  48. Zischinsky G, Stragies R, Schaudt M, Pfeifer J, Gibson C, Locardi E, et al. Novel small molecule bradykinin B1 receptor antagonists. Part 2: 5-membered diaminoheterocycles. Bioorg Med Chem Lett. 2010;20:1229-32 pubmed publisher
    ..Subsequent transformation into five-membered diaminoheterocycle derivatives and their synthesis and SAR is described. This resulted in compounds with low nanomolar activity. ..
  49. Kim M, Kim H, Kim H, Chin J. Synthesis of Enantiopure Mixed Alkyl-Aryl Vicinal Diamines by the Diaza-Cope Rearrangement: A Synthesis of (+)-CP-99,994. J Org Chem. 2017;: pubmed publisher
    The stereoselective synthesis of mixed alkyl-aryl vicinal diamines was demonstrated by the use of 1,2-bis(2-hydroxyphenyl)-1,2-diaminoethene (hpen)...
  50. Jeyakkumar P, Liu H, Gopala L, Cheng Y, Peng X, Geng R, et al. Novel benzimidazolyl tetrahydroprotoberberines: Design, synthesis, antimicrobial evaluation and multi-targeting exploration. Bioorg Med Chem Lett. 2017;27:1737-1743 pubmed publisher
    ..synthesized from berberine via direct cyclization of tetrahydroprotoberberine aldehyde and o-phenylene diamines under metal-free aerobic oxidation...
  51. Zhou J, Mei Y, Pan Z, Zhou H. Structure, DNA binding and cleavage of a new Zn(II)Mn(II) macrocyclic complex. Spectrochim Acta A Mol Biomol Spectrosc. 2012;99:329-34 pubmed publisher
    ..37 × 10(3)M(-1). The agarose gel electrophoresis studies show that pBR322 plasmid DNA can be transformed to nicked form and linear form in air by the complex. ..
  52. Nielsen S, Pedersen C, Hansen S, Petersen M, Sinning S, Wiborg O, et al. An extended study of dimeric phenyl tropanes. Bioorg Med Chem. 2009;17:4900-9 pubmed publisher
    ..The diamines used were a variety of linear, cyclic and aromatic diamines, while the diol tethered compounds were prepared by '..
  53. López Galindo C, Vargas Chacoff L, Nebot E, Casanueva J, Rubio D, Mancera J, et al. Sublethal responses of the common mussel (Mytilus galloprovincialis) exposed to sodium hypochlorite and Mexel432 used as antifoulants. Ecotoxicol Environ Saf. 2010;73:825-34 pubmed publisher
    ..Exposure to NaClO caused a greater toxicological response than Mexel432. In both treatments, gills appeared to be the most affected tissue, although Mexel432 also significantly affected digestive gland parameters. ..
  54. Meng J, Cheng X, Liu J, Zhang W, Li X, Kong H, et al. Effects of long and short carboxylated or aminated multiwalled carbon nanotubes on blood coagulation. PLoS ONE. 2012;7:e38995 pubmed publisher
    ..The effects of MWCNTs depended on the size and chemistry of the nanotubes and the type of cells they contacted...
  55. Stolic I, Baric D, Kazazić S, Bratos I, Bajic M. Mechanistic investigation of charge-remote and charge-driven fragmentation processes in 2,5-diphenyl-3,4-ethylenedioxythiophene diamidines. Rapid Commun Mass Spectrom. 2016;30:933-43 pubmed publisher
  56. Faller R, Eversole S, Saunders Burkhardt K. Protective benefits of a stabilised stannous-containing fluoride dentifrice against erosive acid damage. Int Dent J. 2014;64 Suppl 1:29-34 pubmed publisher
  57. McClymont D, Harris J, Mellor I. Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors. Eur J Pharmacol. 2012;686:22-31 pubmed publisher
    ..We conclude that GluN3B-containing receptors provide increased resistance to channel block compared to GluN3A-containing receptors and this must be due to differences outside the deep pore region (N site and deeper)...
  58. Wang J, Liu X, Dong S, Lin L, Feng X. Asymmetric organocatalytic cyclopropanation of cinnamone derivatives with stabilized sulfonium ylides. J Org Chem. 2013;78:6322-7 pubmed publisher
    ..The desired cyclopropanation adducts were obtained in moderate yields (up to 68%) with good enantioselectivities (67-93% ee) and excellent diastereoselectivities (>95:5) under mild conditions. ..
  59. Hayat A, Haider W, Rolland M, Marty J. Electrochemical grafting of long spacer arms of hexamethyldiamine on a screen printed carbon electrode surface: application in target induced ochratoxin A electrochemical aptasensor. Analyst. 2013;138:2951-7 pubmed publisher
    ..The aptamer gates were closed due to change in conformation of aptamer upon target analyte binding, decreasing the electrochemical signal. The decrease in electrochemical signal was used for the detection of target molecule...
  60. Kurokawa T, Kim M, Du Bois J. Synthesis of 1,3-diamines through rhodium-catalyzed C-H insertion. Angew Chem Int Ed Engl. 2009;48:2777-9 pubmed publisher
    ..With the advent of new protocols that facilitate ring opening of the six-membered-ring heterocyclic products, access to differentially protected 1,3-diamines has been made possible (see scheme).
  61. Wu J, Wang D, Wu F, Wan B. Cu(OTf)2-catalyzed asymmetric Friedel-Crafts alkylation reaction of indoles with arylidene malonates using bis(sulfonamide)-diamine ligands. J Org Chem. 2013;78:5611-7 pubmed publisher
    ..The desired products were obtained in up to 99% yield with 96% ee...
  62. Hannig C, Gaeding A, Basche S, Richter G, Helbig R, Hannig M. Effect of conventional mouthrinses on initial bioadhesion to enamel and dentin in situ. Caries Res. 2013;47:150-61 pubmed publisher
    ..The study aimed to investigate the effect of a customary fluoride solution, containing sodium fluoride and amine fluoride, on initial biofilm formation on enamel and dentin in situ compared directly to chlorhexidine...
  63. Akita M, Seto H, Aoyama R, Kimura J, Kobayashi K. Novel rearrangements in the reactions directed toward preparation of spiro-N,N-ketals: reactions of naphthalene-1,8-diamine with ninhydrin and isatin. Molecules. 2012;17:13879-90 pubmed publisher
    ..Compound 8 was revealed to undergo a fast dynamic prototropic tautomerization in solution. Plausible mechanisms of the formation of the products are proposed...
  64. Wang R, Jiang H. 1,6-Hexanediamine methanesulfonate: a mild and efficient catalyst for the tetrahydropyranylation of alcohols under solvent-free conditions. Prep Biochem Biotechnol. 2010;40:171-6 pubmed publisher
    ..It affords the corresponding tetrahydropyranyl ethers in good yields at a faster rate in the absence of solvent...
  65. Lavrado J, Mackey Z, Hansell E, McKerrow J, Paulo A, Moreira R. Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives. Bioorg Med Chem Lett. 2012;22:6256-60 pubmed publisher
    ..Overall, these compounds with good antitrypanosomal activity and selectivity provide an encouraging starting point for the rational design of new and effective antitrypanosomal agents...
  66. Li X, Huang J, Yang L. Iron(III)-promoted oxidative coupling of naphthylamines: synthetic and mechanistic investigations. Org Lett. 2011;13:4950-3 pubmed publisher
    A facile route to the synthesis of 1,1'-binaphthyl-4,4'-diamines (naphthidines) and 1,1'-binaphthyl-2,2'-diamines (BINAMs) was developed by the oxidative homocoupling of 1- and 2-naphthylamines, respectively, using FeCl(3) as oxidant and ..
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    ..Only the compound BA1,2-DAE, showed significant antifungal activity against Microsporum canis (80%)...
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    ..The activity, stability, low cost of starting materials, and straightforward synthesis make amino squaramides appropriate molecules for the development of an affordable anti-Chagasic agent. ..