polyamines

Summary

Summary: Amine compounds that consist of carbon chains or rings containing two or more primary amino groups.

Top Publications

  1. Lewandowski N, Ju S, Verbitsky M, Ross B, Geddie M, Rockenstein E, et al. Polyamine pathway contributes to the pathogenesis of Parkinson disease. Proc Natl Acad Sci U S A. 2010;107:16970-5 pubmed publisher
    ..First, to test for a causal link between polyamines and α-synuclein toxicity, we investigated a yeast model expressing α-synuclein...
  2. Di Iorio B, MOLONY D, Bell C, Cucciniello E, Bellizzi V, Russo D, et al. Sevelamer versus calcium carbonate in incident hemodialysis patients: results of an open-label 24-month randomized clinical trial. Am J Kidney Dis. 2013;62:771-8 pubmed publisher
    ..Whether the use of sevelamer rather than a calcium-containing phosphate binder improves cardiovascular (CV) survival in patients receiving dialysis remains to be elucidated...
  3. Thurlow L, Joshi G, Clark J, Spontak J, Neely C, Maile R, et al. Functional modularity of the arginine catabolic mobile element contributes to the success of USA300 methicillin-resistant Staphylococcus aureus. Cell Host Microbe. 2013;13:100-7 pubmed publisher
    ..Consequently, the ACME-Arc system drives excessive production of host polyamines, compounds uniquely toxic to S. aureus...
  4. Bridoux M, Ingalls A. Diatom microfossils from cretaceous and eocene sediments contain native silica precipitating long-chain polyamines. Geobiology. 2013;11:215-23 pubmed publisher
    ..Here, we report that nitrogen-rich aliphatic long-chain polyamines (LCPAs), biosynthesized by diatoms in species-specific assemblages for the precipitation of nanopatterned ..
  5. Luo J, Yu C, Yu H, Borštnar R, Kamerlin S, Gräslund A, et al. Cellular polyamines promote amyloid-beta (A?) peptide fibrillation and modulate the aggregation pathways. ACS Chem Neurosci. 2013;4:454-62 pubmed publisher
    The cellular polyamines spermine, spermidine, and their metabolic precursor putrescine, have long been associated with cell-growth, tumor-related gene regulations, and Alzheimer's disease...
  6. Li M, Sun Y, Tomiya N, Hsu Y, Chai T. Elevated polyamines in urothelial cells from OAB subjects mediate oxotremorine-evoked rapid intracellular calcium rise and delayed acetylcholine release. Am J Physiol Renal Physiol. 2013;305:F445-50 pubmed publisher
    ..We assessed whether polyamines modulated rapid intracellular calcium ([Ca(2+)]i) changes and delayed acetylcholine (ACh) release evoked by ..
  7. Liu R, Li Q, Ma R, Lin X, Xu H, Bi K. Determination of polyamine metabolome in plasma and urine by ultrahigh performance liquid chromatography-tandem mass spectrometry method: application to identify potential markers for human hepatic cancer. Anal Chim Acta. 2013;791:36-45 pubmed publisher
    ..a UHPLC-MS/MS method has been developed and validated for simultaneous determination of polyamine precursors, polyamines, polyamine catabolite in human plasma and urine...
  8. Gupta V, Scheunemann L, Eisenberg T, Mertel S, Bhukel A, Koemans T, et al. Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner. Nat Neurosci. 2013;16:1453-60 pubmed publisher
    ..b>Polyamines are among the substances found to decrease with age in the human brain...
  9. Liew L, Pearce A, Kaiser M, Copp B. Synthesis and in vitro and in vivo evaluation of antimalarial polyamines. Eur J Med Chem. 2013;69:22-31 pubmed publisher
    ..and biologically tested a library that includes benzamide and 3-phenylpropanamide 'capping acid' groups, and polyamines that include spermine (PA3-4-3) and chain extended analogues PA3-8-3 and PA3-12-3...

More Information

Publications88

  1. Kaddour H, Vergne J, Herve G, Maurel M. Inhibition by polyamines of the hammerhead ribozyme from a Chrysanthemum chlorotic mottle viroid. Biochim Biophys Acta. 2014;1840:1670-5 pubmed publisher
    ..They infect plants and cause considerable economic losses. The members of the Avsunviroidae family are known for their capability to form hammerhead ribozymes (HHR) that catalyze self-cleavage during their rolling circle replication...
  2. Di Martino M, Campilongo R, Casalino M, Micheli G, Colonna B, Prosseda G. Polyamines: emerging players in bacteria-host interactions. Int J Med Microbiol. 2013;303:484-91 pubmed publisher
    b>Polyamines are small polycationic molecules found in almost all cells and associated with a wide variety of physiological processes...
  3. Shi H, Ye T, Chan Z. Comparative proteomic and physiological analyses reveal the protective effect of exogenous polyamines in the bermudagrass (Cynodon dactylon) response to salt and drought stresses. J Proteome Res. 2013;12:4951-64 pubmed publisher
    b>Polyamines conferred enhanced abiotic stress tolerance in multiple plant species. However, the effect of polyamines on abiotic stress and physiological change in bermudagrass, the most widely used warm-season turfgrasses, are unknown...
  4. North M, Grasemann H, Khanna N, Inman M, Gauvreau G, Scott J. Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma. Am J Respir Cell Mol Biol. 2013;48:694-702 pubmed publisher
    ..The product of arginase activity, L-ornithine, can be metabolized into polyamines by ornithine decarboxylase...
  5. Willert E, Phillips M. Regulation and function of polyamines in African trypanosomes. Trends Parasitol. 2012;28:66-72 pubmed publisher
    ..In Trypanosoma brucei, AdoMetDC activity appears to be controlled by regulation of prozyme protein levels, potentially at the translational level. ..
  6. Chaturvedi R, Asim M, Hoge S, Lewis N, Singh K, Barry D, et al. Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production. Gastroenterology. 2010;139:1686-98, 1698.e1-6 pubmed publisher
    ..Up-regulation of ODC in gastric macrophages impairs host defense against H pylori by suppressing iNOS-derived NO production. ..
  7. García Faroldi G, Rodriguez C, Urdiales J, Pérez Pomares J, Dávila J, Pejler G, et al. Polyamines are present in mast cell secretory granules and are important for granule homeostasis. PLoS ONE. 2010;5:e15071 pubmed publisher
    ..b>Polyamines (putrescine, spermidine and spermine) are absolutely required for the survival of the vast majority of living ..
  8. Tummala R, Diegelman P, Hector S, Kramer D, Clark K, Zagst P, et al. Combination effects of platinum drugs and N1, N11 diethylnorspermine on spermidine/spermine N1-acetyltransferase, polyamines and growth inhibition in A2780 human ovarian carcinoma cells and their oxaliplatin and cisplatin-resistant variants. Cancer Chemother Pharmacol. 2011;67:401-14 pubmed publisher
    ..the effects of oxaliplatin and cisplatin when combined with DENSPM on the induction of SSAT mRNA, activity, polyamines and cell growth in A2780 human ovarian carcinoma cells and their oxaliplatin- and cisplatin-resistant variants ..
  9. Ramos J, Rege K. Transgene delivery using poly(amino ether)-gold nanorod assemblies. Biotechnol Bioeng. 2012;109:1336-46 pubmed publisher
    ..PAE-GNRs also have the potential to be used simultaneously for photothermal ablation, photothermally enhanced drug and gene delivery, and biological imaging, thus making them a powerful theranostic platform. ..
  10. Choudhary S, Kanwar M, Bhardwaj R, Yu J, Tran L. Chromium stress mitigation by polyamine-brassinosteroid application involves phytohormonal and physiological strategies in Raphanus sativus L. PLoS ONE. 2012;7:e33210 pubmed publisher
    Brassinosteroids (BRs) and polyamines (PAs) are well-established growth regulators playing key roles in stress management among plants...
  11. Choudhary S, Kanwar M, Bhardwaj R, Gupta B, Gupta R. Epibrassinolide ameliorates Cr (VI) stress via influencing the levels of indole-3-acetic acid, abscisic acid, polyamines and antioxidant system of radish seedlings. Chemosphere. 2011;84:592-600 pubmed publisher
  12. Hamdani S, Yaakoubi H, Carpentier R. Polyamines interaction with thylakoid proteins during stress. J Photochem Photobiol B. 2011;104:314-9 pubmed publisher
    The involvement of polyamines in plant responses to abiotic stresses is well investigated, while there has been few reports on the specific mode of action of polyamines on the photosynthetic apparatus...
  13. Zou T, Rao J, Liu L, Xiao L, Cui Y, Jiang Z, et al. Polyamines inhibit the assembly of stress granules in normal intestinal epithelial cells regulating apoptosis. Am J Physiol Cell Physiol. 2012;303:C102-11 pubmed publisher
    b>Polyamines regulate multiple signaling pathways and are implicated in many aspects of cellular functions, but the exact molecular processes governed by polyamines remain largely unknown...
  14. Bassard J, Ullmann P, Bernier F, Werck Reichhart D. Phenolamides: bridging polyamines to the phenolic metabolism. Phytochemistry. 2010;71:1808-24 pubmed publisher
    ..and quantitatively major group of secondary metabolites resulting from the conjugation of a phenolic moiety with polyamines or with deaminated aromatic aminoacids...
  15. Gomez Jimenez M, Paredes M, Gallardo M, Sanchez Calle I. Mature fruit abscission is associated with up-regulation of polyamine metabolism in the olive abscission zone. J Plant Physiol. 2010;167:1432-41 pubmed publisher
    This study investigates whether, and how, polyamines (PAs) are involved in mature fruit abscission of olive (Olea europaea L.)...
  16. Fortes A, Costa J, Santos F, Segui Simarro J, Palme K, Altabella T, et al. Arginine Decarboxylase expression, polyamines biosynthesis and reactive oxygen species during organogenic nodule formation in hop. Plant Signal Behav. 2011;6:258-69 pubmed
    ..b>Polyamines are involved in plant development and stress responses. Arginine decarboxylase (ADC; EC 4·1...
  17. Boaz M, Katzir Z, Schwartz D, Gafter U, Biro A, Shtendik L, et al. Effect of sevelamer hydrochloride exposure on carotid intima media thickness in hemodialysis patients. Nephron Clin Pract. 2011;117:c83-8 pubmed publisher
    ..Sevelamer hydrochloride was associated with lower carotid IMT. This association may be mediated through reduction in Ca load, low-density lipoprotein cholesterol lowering or some other pleiotropic effect. ..
  18. Vlassara H, Cai W, Chen X, Serrano E, Shobha M, Uribarri J, et al. Managing chronic inflammation in the aging diabetic patient with CKD by diet or sevelamer carbonate: a modern paradigm shift. J Gerontol A Biol Sci Med Sci. 2012;67:1410-6 pubmed publisher
    ..If larger and longer studies confirm the hypothesis that one or both of these interventions reduce progression of CKD, it could represent a new paradigm in the management of complications in the type 2 diabetes patient with CKD. ..
  19. Iwashita Y, Sakiyama T, Musch M, Ropeleski M, Tsubouchi H, Chang E. Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response. Am J Physiol Gastrointest Liver Physiol. 2011;301:G181-7 pubmed publisher
    ..Thus we investigated whether polyamines (putrescine, spermidine, or spermine) and their precursor ornithine mediate the induction of Hsp expression in ..
  20. Kronek J, Paulovicova E, Paulovicová L, Kronekova Z, Lustoň J. Immunomodulatory efficiency of poly(2-oxazolines). J Mater Sci Mater Med. 2012;23:1457-64 pubmed publisher
    ..The present study revealed effective structure-immunomodulating associations of AEOX10 and PETOX100, which are desirable in biomedical and pharmaceutical applications of aliphatic and aromatic poly (2-oxazolines) in vivo. ..
  21. Takahashi Y, Cong R, Sagor G, Niitsu M, Berberich T, Kusano T. Characterization of five polyamine oxidase isoforms in Arabidopsis thaliana. Plant Cell Rep. 2010;29:955-65 pubmed publisher
    ..AtPAO4 seemed to be spermine (Spm)-specific. More interestingly, AtPAO1 preferred thermospermine (T-Spm) and norspermine (NorSpm) to Spm, but did not recognize Spd. Based on the results, the individual function of AtPAOs is discussed. ..
  22. Ikee R, Tsunoda M, Sasaki N, Sato N, Hashimoto N. Potential influence of sevelamer hydrochloride on responsiveness to erythropoiesis-stimulating agents in haemodialysis patients. Nephrology (Carlton). 2012;17:225-9 pubmed publisher
    ..Further studies are required to investigate the causal relationship between sevelamer and ESA responsiveness. ..
  23. Vlassara H, Uribarri J, Cai W, Goodman S, Pyzik R, Post J, et al. Effects of sevelamer on HbA1c, inflammation, and advanced glycation end products in diabetic kidney disease. Clin J Am Soc Nephrol. 2012;7:934-42 pubmed publisher
    ..These novel actions of sevelamer carbonate on metabolic and inflammatory abnormalities in type 2 diabetes mellitus may affect progression of early diabetic CKD. ..
  24. Lin Y, Chen Y, Hung K, Chu T, Kan W, Huang C, et al. Benefits of sevelamer on markers of bone turnover in Taiwanese hemodialysis patients. J Formos Med Assoc. 2010;109:663-72 pubmed publisher
    ..Sevelamer is an effective means of treatment for chronic hyperphosphatemic HD patients, especially those with hypoparathyroidism. ..
  25. Kang H, Kang H, Bae Y. A reducible polycationic gene vector derived from thiolated low molecular weight branched polyethyleneimine linked by 2-iminothiolane. Biomaterials. 2011;32:1193-203 pubmed publisher
    ..8 kDa)/pDNA. Thus, the results of the present study suggest that RPC-bPEI(0.8 kDa) has the potential to effectively deliver genetic materials with lower levels of toxicity. ..
  26. Kronek J, Kronekova Z, Lustoň J, Paulovicova E, Paulovicová L, Mendrek B. In vitro bio-immunological and cytotoxicity studies of poly(2-oxazolines). J Mater Sci Mater Med. 2011;22:1725-34 pubmed publisher
    ..Overall, the tested polymers demonstrated no significant influences on the cellular immunological parameters. ..
  27. Reyes Becerril M, Ascencio Valle F, Tovar Ramirez D, Meseguer J, Esteban M. Effects of polyamines on cellular innate immune response and the expression of immune-relevant genes in gilthead seabream leucocytes. Fish Shellfish Immunol. 2011;30:248-54 pubmed publisher
    It is well known that the polyamines spermidine and spermine, along with the diamine putrescine, are involved in many cellular processes and they are known to play an important role in the control of the innate immune response in higher ..
  28. Michael A. Exploring polyamine biosynthetic diversity through comparative and functional genomics. Methods Mol Biol. 2011;720:39-50 pubmed publisher
    ..the presence of alternative polyamine structural analogs, is an indication of the physiological importance of polyamines and their long evolutionary history...
  29. Tsiavos T, Ioannidis N, Kotzabasis K. Polyamines induce aggregation of LHC II and quenching of fluorescence in vitro. Biochim Biophys Acta. 2012;1817:735-43 pubmed publisher
    ..We showed in previous works that polyamines stimulate qE in higher plants in vivo and in eukaryotic algae in vitro...
  30. Cancela A, Oliveira R, Graciolli F, dos Reis L, Barreto F, Barreto D, et al. Fibroblast growth factor 23 in hemodialysis patients: effects of phosphate binder, calcitriol and calcium concentration in the dialysate. Nephron Clin Pract. 2011;117:c74-82 pubmed publisher
    ..Fibroblast growth factor 23 (FGF23) concentrations increase early in chronic kidney disease (CKD), and the influence of current CKD-mineral and bone disorder (MBD) therapies on serum FGF23 levels is still under investigation...
  31. Rao J, Rathor N, Zhuang R, Zou T, Liu L, Xiao L, et al. Polyamines regulate intestinal epithelial restitution through TRPC1-mediated Ca²+ signaling by differentially modulating STIM1 and STIM2. Am J Physiol Cell Physiol. 2012;303:C308-17 pubmed publisher
    ..b>Polyamines stimulate intestinal epithelial restitution, but their exact mechanism remains unclear...
  32. Nikolov I, Joki N, Nguyen Khoa T, Guerrera I, Maizel J, Benchitrit J, et al. Lanthanum carbonate, like sevelamer-HCl, retards the progression of vascular calcification and atherosclerosis in uremic apolipoprotein E-deficient mice. Nephrol Dial Transplant. 2012;27:505-13 pubmed publisher
    ..We compared the effect of phosphate binder lanthanum (La) carbonate with sevelamer-HCl on atherosclerosis, VC and bone structure and function in mice with chronic renal failure (CRF)...
  33. Choudhary S, Bhardwaj R, Gupta B, Dutt P, Gupta R, Biondi S, et al. Epibrassinolide induces changes in indole-3-acetic acid, abscisic acid and polyamine concentrations and enhances antioxidant potential of radish seedlings under copper stress. Physiol Plant. 2010;140:280-96 pubmed publisher
  34. Ramot Y, Pietilä M, Giuliani G, Rinaldi F, Alhonen L, Paus R. Polyamines and hair: a couple in search of perfection. Exp Dermatol. 2010;19:784-90 pubmed publisher
    b>Polyamines (spermidine, putrescine and spermine) are multifunctional cationic amines that are indispensable for cellular proliferation; of key significance in the growth of rapidly regenerating tissues and tumors...
  35. Becker J, Mtwisha L, Crampton B, Stoychev S, van Brummelen A, Reeksting S, et al. Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels. BMC Genomics. 2010;11:235 pubmed publisher
    ..falciparum spermidine synthase (PfSpdSyn) were examined on a morphological, transcriptomic, proteomic and metabolic level...
  36. van Kuringen H, Lenoir J, Adriaens E, Bender J, De Geest B, Hoogenboom R. Partial hydrolysis of poly(2-ethyl-2-oxazoline) and potential implications for biomedical applications?. Macromol Biosci. 2012;12:1114-23 pubmed publisher
    ..Mucosal irritation and cytotoxicity is also absent up to 10% hydrolysis levels. In conclusion, PEtOx will not decompose at physiological conditions, and partial hydrolysis will not limit its biomedical applications...
  37. Goto S, Yoshiya K, Kita T, Fujii H, Fukagawa M. Uremic toxins and oral adsorbents. Ther Apher Dial. 2011;15:132-4 pubmed publisher
    ..Oral adsorbents are thus one of the important modalities in the treatment of uremic syndrome...
  38. Zhou Q, Yu B. Changes in content of free, conjugated and bound polyamines and osmotic adjustment in adaptation of vetiver grass to water deficit. Plant Physiol Biochem. 2010;48:417-25 pubmed publisher
    Osmotic adjustment and alteration of polyamines (PAs) have been suggested to play roles in plant adaptation to water deficit/drought stress...
  39. Morimoto N, Fukuda W, Nakajima N, Masuda T, Terui Y, Kanai T, et al. Dual biosynthesis pathway for longer-chain polyamines in the hyperthermophilic archaeon Thermococcus kodakarensis. J Bacteriol. 2010;192:4991-5001 pubmed publisher
    Long-chain and/or branched-chain polyamines are unique polycations found in thermophiles. Cytoplasmic polyamines were analyzed for cells cultivated at various growth temperatures in the hyperthermophilic archaeon Thermococcus kodakarensis...
  40. Zou T, Rao J, Liu L, Xiao L, Yu T, Jiang P, et al. Polyamines regulate the stability of JunD mRNA by modulating the competitive binding of its 3' untranslated region to HuR and AUF1. Mol Cell Biol. 2010;30:5021-32 pubmed publisher
    b>Polyamines critically regulate all mammalian cell growth and proliferation by mechanisms such as the repression of growth-inhibitory proteins, including JunD...
  41. Arenas M, Rebollo P, Malek T, Moledous A, Gil M, Alvarez Ude F, et al. A comparative study of 2 new phosphate binders (sevelamer and lanthanum carbonate) in routine clinical practice. J Nephrol. 2010;23:683-92 pubmed
    ..The aim of this study was to compare the cost-consequences of changing from S to LC...
  42. Zhou J, Zhang H, Wu J, Liu Q, Xi P, Lee J, et al. A novel multidomain polyketide synthase is essential for zeamine production and the virulence of Dickeya zeae. Mol Plant Microbe Interact. 2011;24:1156-64 pubmed publisher
    ..e., zeamine and zeamine II, that were phytotoxins and potent antibiotics. These results have established the essential role of ZmsA in zeamine biosynthesis and presented a new insight on the molecular mechanisms of D. zeae pathogenicity...
  43. Lefèvre P, Palin M, Murphy B. Polyamines on the reproductive landscape. Endocr Rev. 2011;32:694-712 pubmed publisher
    The polyamines are ubiquitous polycationic compounds...
  44. Navarro González J, Mora Fernández C, Muros de Fuentes M, Donate Correa J, Cazaña Pérez V, Garcia Perez J. Effect of phosphate binders on serum inflammatory profile, soluble CD14, and endotoxin levels in hemodialysis patients. Clin J Am Soc Nephrol. 2011;6:2272-9 pubmed publisher
    ..We evaluated the effects of calcium acetate and sevelamer hydrochloride on serum inflammatory profile, endotoxin concentrations, and sCD14 levels in HD patients...
  45. Iacomino G, Picariello G, D Agostino L. DNA and nuclear aggregates of polyamines. Biochim Biophys Acta. 2012;1823:1745-55 pubmed publisher
    b>Polyamines (PAs) are linear polycations that are involved in many biological functions...
  46. Bernier S, Létoffé S, Delepierre M, Ghigo J. Biogenic ammonia modifies antibiotic resistance at a distance in physically separated bacteria. Mol Microbiol. 2011;81:705-16 pubmed publisher
    ..that exposure to ammonia generated by the catabolism of l-aspartate increases the level of intracellular polyamines, in turn leading to modifications in membrane permeability to different antibiotics as well as increased ..
  47. Stinghen A, Gonçalves S, Bucharles S, Branco F, Gruber B, Hauser A, et al. Sevelamer decreases systemic inflammation in parallel to a reduction in endotoxemia. Blood Purif. 2010;29:352-6 pubmed publisher
    ..In the present study, we investigated the impact of sevelamer hydrochloride treatment in reducing endotoxemia and inflammation in a group of hemodialysis (HD) patients...
  48. Silva M, Klafke J, Rossato M, Gewehr C, Guerra G, Rubin M, et al. Role of peripheral polyamines in the development of inflammatory pain. Biochem Pharmacol. 2011;82:269-77 pubmed publisher
    b>Polyamines (putrescine, spermidine and spermine) are aliphatic amines that are produced by the action of ornithine decarboxylase (ODC) in a rate-limiting and protein kinase C (PKC)-regulated step...
  49. Jelsbak L, Thomsen L, Wallrodt I, Jensen P, Olsen J. Polyamines are required for virulence in Salmonella enterica serovar Typhimurium. PLoS ONE. 2012;7:e36149 pubmed publisher
    ..Here we identify polyamines as novel environmental signals essential for virulence of Salmonella enterica serovar Typhimurium, a major ..
  50. Lin H, Lien Y, Hsu C. A high-throughput colorimetric assay to characterize the enzyme kinetic and cellular activity of spermidine/spermine N1-acetyltransferase 1. Anal Biochem. 2010;407:226-32 pubmed publisher
    Spermidine/spermine N(1)-acetyltransferase 1 (SSAT1) is a key enzyme that catalyzes the catabolism of polyamines. SSAT1 is a very important enzyme because it not only maintains the homeostasis of polyamines but also is involved in many ..
  51. Hussain S, Ali M, Ahmad M, Siddique K. Polyamines: natural and engineered abiotic and biotic stress tolerance in plants. Biotechnol Adv. 2011;29:300-11 pubmed publisher
    b>Polyamines (PAs) are ubiquitous biogenic amines that have been implicated in diverse cellular functions in widely distributed organisms...
  52. Terui Y, Akiyama M, Sakamoto A, Tomitori H, Yamamoto K, Ishihama A, et al. Increase in cell viability by polyamines through stimulation of the synthesis of ppGpp regulatory protein and ? protein of RNA polymerase in Escherichia coli. Int J Biochem Cell Biol. 2012;44:412-22 pubmed publisher
    It is known that polyamines increase cell growth through stimulation of the synthesis of several kinds of proteins encoded by the so-called "polyamine modulon"...
  53. Cerrada Gimenez M, Pietilä M, Loimas S, Pirinen E, Hyvonen M, Keinänen T, et al. Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults. Transgenic Res. 2011;20:387-96 pubmed publisher
    ..In the transgenic mice, the age-related repression of the different antioxidant enzymes served as a protection against the hepatotoxic effects of carbon tetrachloride and thioacetamide...
  54. Schneider J, Wendisch V. Biotechnological production of polyamines by bacteria: recent achievements and future perspectives. Appl Microbiol Biotechnol. 2011;91:17-30 pubmed publisher
    ..Some of these polyamines are of special interest due to their use in the production of engineering plastics (e.g...
  55. Xiao L, Wang J. Posttranscriptional regulation of gene expression in epithelial cells by polyamines. Methods Mol Biol. 2011;720:67-79 pubmed publisher
    In addition to regulating gene transcription, polyamines also potently modulate gene expression posttranscriptionally...
  56. Zepeda Jazo I, Velarde Buendía A, Enríquez Figueroa R, Bose J, Shabala S, Muñiz Murguía J, et al. Polyamines interact with hydroxyl radicals in activating Ca(2+) and K(+) transport across the root epidermal plasma membranes. Plant Physiol. 2011;157:2167-80 pubmed publisher
    ..Contrary to expectations, polyamines (PAs) did not inhibit the OH(•)-induced cation fluxes...
  57. Piron J, Choveau F, Amarouch M, Rodriguez N, Charpentier F, Merot J, et al. KCNE1-KCNQ1 osmoregulation by interaction of phosphatidylinositol-4,5-bisphosphate with Mg2+ and polyamines. J Physiol. 2010;588:3471-83 pubmed publisher
    ..Furthermore, we showed that polyamines and Mg(2+), already known to tonically inhibit KCNQ channels by screening PIP(2) negative charges, are involved ..
  58. Kucharzewska P, Welch J, Svensson K, Belting M. Ornithine decarboxylase and extracellular polyamines regulate microvascular sprouting and actin cytoskeleton dynamics in endothelial cells. Exp Cell Res. 2010;316:2683-91 pubmed publisher
    The polyamines are essential for cancer cell proliferation during tumorigenesis. Targeted inhibition of ornithine decarboxylase (ODC), i.e...
  59. Wimalasekera R, Tebartz F, Scherer G. Polyamines, polyamine oxidases and nitric oxide in development, abiotic and biotic stresses. Plant Sci. 2011;181:593-603 pubmed publisher
    Nitric oxide (NO), polyamines (PAs), diamine oxidases (DAO) and polyamine oxidases (PAO) play important roles in wide spectrum of physiological processes such as germination, root development, flowering and senescence and in defence ..
  60. Thompson P, Wertheim B, Zell J, Chen W, McLaren C, Lafleur B, et al. Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma. Gastroenterology. 2010;139:797-805, 805.e1 pubmed publisher
    ..We analyzed rectal mucosal levels of polyamines (spermidine, spermine, and putrescine) and PGE2, treatment regimens, and risk of CRA in 267 participants of a ..
  61. Nasrallah G, Riveroll A, Chong A, Murray L, Lewis P, Garduno R. Legionella pneumophila requires polyamines for optimal intracellular growth. J Bacteriol. 2011;193:4346-60 pubmed publisher
    ..pneumophila may require exogenous polyamines for growth. A pharmacological inhibitor of SAMDC significantly reduced L...
  62. Pegg A, Casero R. Current status of the polyamine research field. Methods Mol Biol. 2011;720:3-35 pubmed publisher
    ..These chapters provide a wide range of methods, advice, and background relevant to studies of the function of polyamines, the regulation of their content, their role in disease, and the therapeutic potential of drugs targeting ..
  63. Lee N, MacLean H. Polyamines, androgens, and skeletal muscle hypertrophy. J Cell Physiol. 2011;226:1453-60 pubmed publisher
    The naturally occurring polyamines, spermidine, spermine, and their precursor putrescine, play indispensible roles in both prokaryotic and eukaryotic cells, from basic DNA synthesis to regulation of cell proliferation and differentiation...
  64. Savarin P, Barbet A, Delga S, Joshi V, Hamon L, Lefevre J, et al. A central role for polyamines in microtubule assembly in cells. Biochem J. 2010;430:151-9 pubmed publisher
    ..to preferential electrostatic adsorption of multivalent cations on highly anionic surfaces, natural multivalent polyamines and especially quadrivalent spermine can be considered as potential regulators of the complex dynamical ..
  65. Choudhary S, Oral H, Bhardwaj R, Yu J, Tran L. Interaction of brassinosteroids and polyamines enhances copper stress tolerance in raphanus sativus. J Exp Bot. 2012;63:5659-75 pubmed publisher
    Brassinosteroids (BRs) and polyamines (PAs) regulate various responses to abiotic stress, but their involvement in the regulation of copper (Cu) homeostasis in plants exposed to toxic levels of Cu is poorly understood...
  66. Fischer W, Brissault B, Prévost S, Kopaczynska M, Andreou I, Janosch A, et al. Synthesis of linear polyamines with different amine spacings and their ability to form dsDNA/siRNA complexes suitable for transfection. Macromol Biosci. 2010;10:1073-83 pubmed publisher
    ..The polyplex formation between model nucleotide (dsDNA) and these linear polyamines has been determined at different nitrogen to phosphorus (N/P) ratios using small-angle neutron scattering (SANS) ..
  67. Ruhayel R, Langner J, Oke M, Berners Price S, Zgani I, Farrell N. Chimeric platinum-polyamines and DNA binding. Kinetics of DNA interstrand cross-link formation by dinuclear platinum complexes with polyamine linkers. J Am Chem Soc. 2012;134:7135-46 pubmed publisher
    ..Treated as a single final product, the rate of formation of the 5'-5' 1,4-GG IXL, k(CH), for 1 (k(CH) = 4.37 × 10(-5) s(-1)) is similar to that of 1,0,1/t,t,t, whereas the value for 1' is marginally higher (k(CH) = 5.4 × 10(-5) s(-1))...
  68. Brauc S, De Vooght E, Claeys M, Geuns J, Hofte M, Angenon G. Overexpression of arginase in Arabidopsis thaliana influences defence responses against Botrytis cinerea. Plant Biol (Stuttg). 2012;14 Suppl 1:39-45 pubmed publisher
    ..cinerea, whereas silencing lines remained as susceptible as the wild type. We discuss how arginase might interact with plant defence mechanisms. These results provide new insights into amino acid metabolic changes under stress...
  69. Brooks W. Autoimmune diseases and polyamines. Clin Rev Allergy Immunol. 2012;42:58-70 pubmed publisher
    ..However, a group of small molecules called polyamines also require SAM for their synthesis...
  70. Codoñer Franch P, Tavárez Alonso S, Murria Estal R, Herrera Martín G, Alonso Iglesias E. Polyamines are increased in obese children and are related to markers of oxidative/nitrosative stress and angiogenesis. J Clin Endocrinol Metab. 2011;96:2821-5 pubmed publisher
    b>Polyamines (putrescine, spermidine, and spermine) are polycationic amines derived from arginine, which is the precursor of nitric oxide (NO)...
  71. Gutiérrez Moreno N, Medrano F, Yatsimirsky A. Schiff base formation and recognition of amino sugars, aminoglycosides and biological polyamines by 2-formyl phenylboronic acid in aqueous solution. Org Biomol Chem. 2012;10:6960-72 pubmed publisher
    ..K(imine) values were observed for 2-FPBA with aminoglycosides (kanamycin, amikacin, gentamicin, neomycin) and polyamines (spermine, spermidine)...
  72. Perez Leal O, Barrero C, Clarkson A, Casero R, Merali S. Polyamine-regulated translation of spermidine/spermine-N1-acetyltransferase. Mol Cell Biol. 2012;32:1453-67 pubmed publisher
    ..of the polyamine catabolic enzyme spermidine/spermine-N(1)-acetyltransferase (SSAT) in response to increased polyamines is an important polyamine homeostatic mechanism...
  73. Di Iorio B, Bellasi A, Russo D. Mortality in kidney disease patients treated with phosphate binders: a randomized study. Clin J Am Soc Nephrol. 2012;7:487-93 pubmed publisher
  74. Carta F, Temperini C, Innocenti A, Scozzafava A, Kaila K, Supuran C. Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010;53:5511-22 pubmed publisher
    Carbonic anhydrases (CAs, EC 4.2.1.1) are inhibited by sulfonamides, phenols, and coumarins. Polyamines such as spermine, spermidine, and many synthetic congeners are described to constitute a novel class of CA inhibitors (CAIs), ..
  75. Teixeira M, Cabrito T, Hanif Z, Vargas R, Tenreiro S, Sá Correia I. Yeast response and tolerance to polyamine toxicity involving the drug : H+ antiporter Qdr3 and the transcription factors Yap1 and Gcn4. Microbiology. 2011;157:945-56 pubmed publisher
    ..QDR3 is shown to confer resistance to the polyamines spermine and spermidine, but, unlike Qdr2, also a determinant of resistance to polyamines, Qdr3 has no apparent ..
  76. Minois N, Carmona Gutierrez D, Madeo F. Polyamines in aging and disease. Aging (Albany NY). 2011;3:716-32 pubmed
    b>Polyamines are polycations that interact with negatively charged molecules such as DNA, RNA and proteins. They play multiple roles in cell growth, survival and proliferation...
  77. Colotti G, Ilari A. Polyamine metabolism in Leishmania: from arginine to trypanothione. Amino Acids. 2011;40:269-85 pubmed publisher
    b>Polyamines (PAs) are essential metabolites in eukaryotes, participating in a variety of proliferative processes, and in trypanosomatid protozoa play an additional role in the synthesis of the critical thiol trypanothione...
  78. Ikeda M, Yoshii T, Matsui T, Tanida T, Komatsu H, Hamachi I. Montmorillonite-supramolecular hydrogel hybrid for fluorocolorimetric sensing of polyamines. J Am Chem Soc. 2011;133:1670-3 pubmed publisher
    Fluorescent sensor materials for rapidly and conveniently detecting polyamines in biological fluids are highly desirable for cancer diagnosis...
  79. Alcázar R, Cuevas J, Planas J, Zarza X, Bortolotti C, Carrasco P, et al. Integration of polyamines in the cold acclimation response. Plant Sci. 2011;180:31-8 pubmed publisher
    ..The obtained data support the previously held idea that polyamines (PAs) are involved in plant responses to cold, although their specific role is still not well understood...