moxisylyte

Summary

Summary: An alpha-adrenergic blocking agent that is used in Raynaud's disease. It is also used locally in the eye to reverse the mydriasis caused by phenylephrine and other sympathomimetic agents. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1312)

Top Publications

  1. Buvat J, Lemaire A, Herbaut Buvat M. Intracavernous pharmacotherapy: comparison of Moxisylyte and prostaglandin E1. Int J Impot Res. 1996;8:41-6 pubmed
    ..e. the alpha-blocking agent Moxisylyte (Mox), and prostaglandin E1 (PGE1)...
  2. Izumi H, Kudo S, Fuino A, Yokoyama E, Ishibashi A. [The effect of moxisylyte hydrochloride in the symptomatic treatment of benign prostatic hyperplasia]. Hinyokika Kiyo. 1989;35:541-9 pubmed
    The clinical effectiveness of moxisylyte hydrochloride (Moxyl, Fuji Rebio), a selective alpha 1-adrenoceptor blocking agent, was investigated in patients with symptomatic benign prostatic hyperplasia...
  3. Doughty M, Lyle W. A review of the clinical pharmacokinetics of pilocarpine, moxisylyte (thymoxamine), and dapiprazole in the reversal of diagnostic pupillary dilation. Optom Vis Sci. 1992;69:358-68 pubmed
    ..The mechanism of action of dapiprazole is thought to be the same as that of moxisylyte (thymoxamine). The human pharmacokinetics for these drugs are reviewed and compared to pilocarpine...
  4. Suzuki R, Sugihara I, Kurimoto S. Effect of moxisylyte hydrochloride (alpha 1-blocker) on the retinal circulation of patients with diabetes mellitus. Ophthalmic Res. 1992;24:274-9 pubmed
    b>Moxisylyte hydrochloride (alpha 1-blocker) selectively vasodilates cerebral vessels without reducing blood pressure...
  5. Neau B, Roux J, Marty J. Metabolism of 14C-moxisylyte after percutaneous application in hairless rat. Arzneimittelforschung. 1998;48:34-8 pubmed
    ..pharmacokinetics of 14C-thymoxamine (4-(2-dimethylaminoethoxy)-5-isopropyl-2-methyl phenyl acetate, CAS 54-32-0, moxisylyte, Carlytène) were studied in female hairless rats following different administration routes: oral, intravenous ..
  6. Zetterstrom C. The effects of thymoxamine, phenylephrine and cyclopentolate on the accommodative process in man. Acta Ophthalmol (Copenh). 1987;65:699-704 pubmed
    ..We conclude from these data that alpha-stimulation by phenylephrine decreases and alpha-inhibition by thymoxamine increases the accommodative amplitude in man.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  7. Buckley C, Curtin D, Docherty J, Eustace P. Ageing and alpha 1 adrenoceptors in the iris. Eye (Lond). 1987;1 ( Pt 2):211-6 pubmed
    ..Therefore age related miosis is not caused by an alteration in alpha 1 receptors with age. ..
  8. Neau B, Lozano P, Gomond P, Roux J, Grislain L, Lambrey B. Comparison of thymoxamine permeation between hairless rat and horse penile mucous membrane using an in vitro diffusion model. Skin Pharmacol. 1994;7:121-9 pubmed
    b>Moxisylyte (or thymoxamine) administered intracavernously is known to improve erection in organically impotent patients...
  9. Sugihara I, Ishibashi T, Furutani S, Kurimoto S. [Acute and chronic effect of moxisylyte hydrochloride on the retinal circulation in diabetes mellitus]. Nippon Ganka Gakkai Zasshi. 1991;95:1135-41 pubmed
    The effect of moxisylyte hydrochloride, a new type alpha 1-blocking vasodilator, on the retinal circulation was investigated in 14 diabetics, using the video-densitometric image analysis of fluorescein angiography...

More Information

Publications75

  1. Hermabessiere J, Costa P, Andro M. [Efficacy and tolerance of intracavernous injection of moxisylyte in patients with erectile dysfunction: double-blind placebo-controlled study]. Prog Urol. 1995;5:985-91 pubmed
    ..To assess the local tolerance and systemic safety of moxisylyte by self-administered injection...
  2. Watanabe K, Hayashi Y, Ikeda K, Ohnishi H. [Effect of moxisylyte on the lower urinary tracts (2). Effect on the urethra in anesthetized dogs]. Nihon Yakurigaku Zasshi. 1991;97:153-65 pubmed
    Effect of moxisylyte on the lower urinary tracts was studied with the urethral pressure profile (UPP) and balloon method in anesthetized female dogs. In the UPP, moxisylyte produced relaxation in both the proximal and distal urethras...
  3. Valcavi R, Dieguez C, Azzarito C, Artioli C, Portioli I, Scanlon M. Alpha-adrenoreceptor blockade with thymoxamine reduces basal thyrotrophin levels but does not influence circadian thyrotrophin changes in man. J Endocrinol. 1987;115:187-91 pubmed
    ..02). Overall TSH secretion was significantly decreased by thymoxamine (mean +/- S.E.M. area 106 +/- 2.45 mU/l per h vs 123.32 +/- 3.68 in the control study; P less than 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS) ..
  4. Liao J, Ting H, Lee S, Yang C, Liou Y, Peng M, et al. Electroacupuncture-induced pressor and chronotropic effects in anesthetized rats. Auton Neurosci. 2006;124:18-25 pubmed
    ..the LFEa induced effects were completely blocked by an intravenous infusion of an alpha-adrenergic blocker (moxisylyte 0.2 mg/min/kg, i.v., for 20 min). A co-infusion with alpha-and beta-adrenergic blockers (propanolol 0...
  5. Poirier M, Riffaud J, Lacolle J, Dupont C. Effects of five alpha-blockers on the hypogastric nerve stimulation of the canine lower urinary tract. J Urol. 1988;140:165-7 pubmed
  6. Bressolle F, Costa P, Rouzier Panis R, Marquer C. Pharmacokinetics of moxisylyte in healthy volunteers after intracavernous injection of increasing doses. Eur J Clin Pharmacol. 1996;49:411-5 pubmed
    The concentration-time profiles of specific metabolites of moxisylyte, an alpha-adrenoceptor blocking agent, in the plasma and urine from 18 healthy volunteers were investigated after intracavernous (IC) administrations at three dose ..
  7. Eyeson Annan M, Hirst L, Battistutta D, Green A. Comparative pupil dilation using phenylephrine alone or in combination with tropicamide. Ophthalmology. 1998;105:726-32 pubmed
    ..This validation study was undertaken to measure the possible underestimation of cataract prevalence in this community study, which may have occurred because of inadequate dilation from phenylephrine alone...
  8. Neau B, Roux J, Lambrey B, Courtiol C, Marty J, Grislain L. Metabolism of 14C-moxisylyte in hairless rat. Comparison between intravenous and oral route. Arzneimittelforschung. 1995;45:10-4 pubmed
    ..of 14C-thymoxamine (4-(2-dimethylaminoethoxy)-5- isopropyl-2-methyl phenyl acetate hydrochloride) (moxisylyte, Carlytène) was studied on female hairless rats...
  9. Pfister C, Cappele O, Dunet F, Bugel H, Grise P. Assessment of the intrinsic urethral sphincter component function in postprostatectomy urinary incontinence. Neurourol Urodyn. 2002;21:194-7 pubmed
    ..5 mg/kg moxisylyte chlorhydrate, an alpha adrenergic blocker...
  10. Patel K. Alpha-adrenoceptor blocking drugs in asthma. Br J Clin Pharmacol. 1976;3:601-5 pubmed
    ..It is suggested that the potentiation of isoprenaline induced bronchodilatation by thymoxamine is mediated by increased cyclic AMP formation in the bronchial smooth muscle...
  11. Bondil P. [The combination of oral trazodone-moxisylyte: diagnostic and therapeutic value in impotence. Report of 110 cases]. Prog Urol. 1992;2:671-4 pubmed
    ..In conclusion, this oral drug test should be used because of its simplicity, safety and real efficacy. The current objectives of this test are to improve the efficacy of oral treatment as a result of pharmacological progress...
  12. Isambert J, Egon G, Colombel P. Adjuvant drug therapy: a review of 30 cases of sacral anterior root stimulator. Neurourol Urodyn. 1993;12:513-5 pubmed
    ..Eighty percent of our patients who required adjuvant therapies have been improved significantly. This confirms the efficiency of adjuvant therapy and speaks for patience...
  13. Wood J, Wild J, Bullimore M, Gilmartin B. Factors affecting the normal perimetric profile derived by automated static threshold LED perimetry. I. Pupil size. Ophthalmic Physiol Opt. 1988;8:26-31 pubmed
    ..The effect was greatest for peripheral locations for both bowl luminances. The fluctuations in perimetric sensitivity increased with peripheral angle and with decrease in pupil size for both bowl luminances...
  14. Schwenn O, Schellein O, Pfeiffer N, Grehn F. [Reduction of endothelial cell number by cataract operation with intraocular thymoxamine administration. A randomized, double-blind study]. Ophthalmologe. 1997;94:136-40 pubmed
    ..Thymoxamine, an alpha-1-receptor blocker, considerably enhances miosis when given intraocularly in combination with acetylcholine. We investigated whether intraocular use of thymoxamine 0.02% reduced the number of endothelial cells...
  15. Nobata K, Fujimura M, Ishiura Y, Hirose T, Furusyou S, Myou S, et al. Alpha(1L)-, but not alpha(1H)-, adrenoceptor antagonist prevents allergic bronchoconstriction in guinea pigs in vivo. Eur J Pharmacol. 2002;452:97-104 pubmed
    ..of specific antagonists of alpha(1)- and alpha(2)-, alpha(1H)-, alpha(1L)-, and alpha(2)-adrenoceptors, namely moxisylyte, prazosin, 3-[N-[2-(4-hydroxy-2-isopropyl-5-methylphenoxy) ethyl]-N-methylaminomethyl]-4-methoxy-2, 5, 6-..
  16. Green K, Chapman J, Cheeks L, Crosby V, Hull D. Morphologic and physiologic effects of thymoxamine on corneal endothelium and ciliary processes. Lens Eye Toxic Res. 1990;7:403-11 pubmed
    ..02%. Replacement of the aqueous humor with 0.02% thymoxamine caused no effect on either the corneal endothelium or ciliary process, whereas 0.2% caused small, but significant, changes in both tissues...
  17. Neau B, Roux J, Courtiol C, Lambrey B, Marty J. Pharmacokinetics study of 14C-moxisylyte after percutaneous application to hairless rat. Arzneimittelforschung. 1995;45:1161-5 pubmed
    ..pharmacokinetic parameters of 14C-thymoxamine (4-(2-dimethylaminoethoxy)-5-isopropyl-2-methyl phenyl acetate, moxisylyte, Carlytène) were studied on female hairless rats. Animals received 30...
  18. Soldati L, Gianesello V, Galbiati I, Gazzaniga A, Virno M. Ocular pharmacokinetics and pharmacodynamics in rabbits of ibopamine, a new mydriatic agent. Exp Eye Res. 1993;56:247-54 pubmed
    ..Pretreatment with reserpine has no effect on the extent of the mydriasis induced by ibopamine...
  19. Bonuso S, Di Stasio E, Marano E, Covelli V, Testa N, Tetto A, et al. The antimigraine effect of ergotamine: a role for alpha-adrenergic blockade?. Acta Neurol (Napoli). 1994;16:1-10 pubmed
    ..Ergotamine target structure could be the trigeminal innervation of the extracranial and/or dural vessels...
  20. Lebib Ben Achour S, Laffont I, Boyer F, Boiteau F, Dizien O. [Intracavernous injections in the treatment of erectile dysfunction in spinal cord injured patients: experience with 36 patients]. Ann Readapt Med Phys. 2001;44:35-40 pubmed
    ..To confirm the efficiency of intracavernous injections in the treatment of erectile dysfunction in spinal cord injured (SCI) patients and to determine the mean necessary dose to obtain functional erection...
  21. Sakakibara R, Hattori T, Uchiyama T, Suenaga T, Takahashi H, Yamanishi T, et al. Are alpha-blockers involved in lower urinary tract dysfunction in multiple system atrophy? A comparison of prazosin and moxisylyte. J Auton Nerv Syst. 2000;79:191-5 pubmed
    ..was designed to evaluate whether the blockade of these receptors by prazosin (a nonselective alpha1 blocker) and moxisylyte (an alpha1A-selective blocker) would improve bladder emptying in patients with MSA...
  22. Imagawa A, Kimura K, Kawanishi Y, Tamura M. Effect of moxisylyte hydrochloride on isolated human penile corpus cavernosum tissue. Life Sci. 1989;44:619-23 pubmed
    The effect of moxisylyte hydrochloride on isolated human penile corpus cavernosum tissue was investigated and compared with other a-adrenergic antagonists...
  23. Bitker M, Veaux Renault V, Pichon J, Perrigot M, Chatelain C. [The uretheral syndrome in men or prostatodynia]. Ann Urol (Paris). 1988;22:373-5 pubmed
    ..They stress the importance of the clinical history and of static sphincterometry in this type of patient...
  24. Costa P, Bressolle F, Bromet Petit M, Mosser J, Sarrazin B. Pharmacokinetics of moxisylyte in healthy volunteers after intravenous and oral administration. J Pharm Sci. 1992;81:1223-6 pubmed
    The concentration-time profiles of metabolites of moxisylyte, an alpha-blocking agent, in the plasma and urine of 12 healthy volunteers were investigated after intravenous (iv) and oral (two formulations) administration...
  25. Watanabe K, Hayashi Y, Ikeda K, Ohnishi H. [Effect of moxisylyte on the lower urinary tracts (1). Effect on the isolated rabbit urethra and bladder]. Nihon Yakurigaku Zasshi. 1991;97:145-51 pubmed
    Effect of moxisylyte on the lower urinary tracts was studied in comparison with those of prazosin and bunazosin in the isolated rabbit bladder and urethra...
  26. Diehl D, Robin A, Wand M. The influence of iris pigmentation on the miotic effect of thymoxamine. Am J Ophthalmol. 1991;111:351-5 pubmed
    ..Thymoxamine appears similar to other adrenergic agents that bind to melanin, delaying onset and strength of action. Its efficacy as presently formulated may be limited, in part, by iris color...
  27. Costa P, Sarrazin B, Bressolle F, Colson M, Bondil P, Saudubray F. Efficiency and side effects of intracavernous injections of moxisylyte in impotent patients: a dose-finding study versus placebo. J Urol. 1993;149:301-5 pubmed
    We assessed the efficiency and tolerance of the alpha-blocking agent moxisylyte in 2 double-blind studies versus placebo performed in 12 neurogenic patients with spinal cord lesions and in 61 patients presenting with either psychogenic ..
  28. Heller P, Perry F, Jewett D, Levine J. Autonomic components of the human pupillary light reflex. Invest Ophthalmol Vis Sci. 1990;31:156-62 pubmed
    ..We propose that redilation primarily involves parasympathetic relaxation, modulated by cholinergic inhibition of the dilator muscle and central sympathetic inhibition of the Edinger-Westphal nucleus...
  29. Relf S, Gharagozloo N, Skuta G, Alward W, Anderson D, Brubaker R. Thymoxamine reverses phenylephrine-induced mydriasis. Am J Ophthalmol. 1988;106:251-5 pubmed
    ..Thymoxamine was useful in individuals with narrow anterior chamber angles who were at risk of acute closed-angle glaucoma following dilation with an adrenergic agent...
  30. Thompson D, Drasdo N. The effect of 0.5% thymoxamine on the pattern-onset electroretinogram. Doc Ophthalmol. 1989;72:47-54 pubmed
    ..These results therefore support the theory and method used for the extraction of the pattern-specific response...
  31. Green K, Crosby V, Cheeks L. Toxicity of intracameral thymoxamine. Lens Eye Toxic Res. 1990;7:121-32 pubmed
    ..This data, together with an earlier report on in vitro studies of thymoxamine, allows the conclusion that 0.02% thymoxamine is a safe concentration for use in the anterior chamber and 0.2% yields adverse reactions...
  32. Bouloux P, Corsello S, Besser M, Grossman A. The acute cardiovascular actions of intravenous thyrotrophin releasing hormone (TRH) in man are mediated by non-catecholaminergic mechanisms. Br J Clin Pharmacol. 1996;42:225-32 pubmed
  33. Costa P, Bressolle F, Sarrazin B, Mosser J, Sabatier R. Dose-related effect of moxisylyte on maximal urethral closing pressure in patients with spinal cord injuries. Clin Pharmacol Ther. 1993;53:443-9 pubmed
    The effects of single intravenous doses of 0.25, 0.50, and 0.75 mg/kg moxisylyte on maximum urethral closure pressure were evaluated in a placebo-controlled double-blind experiment in 20 patients with spinal cord injuries...
  34. Felt D, Frueh B. A pharmacologic study of the sympathetic eyelid tarsal muscles. Ophthalmic Plast Reconstr Surg. 1988;4:15-24 pubmed
    ..5 mm of downward displacement from its tonic position. The inferior tarsal muscle had a mean maximum total excursion of 0.3 mm, with 0.1 mm downward displacement and 0.2 mm upward displacement from its tonic position...
  35. Costa P, Bressolle F, Jarroux E, Sarrazin B, Mosser J, Navratil H, et al. Multiple-dose pharmacokinetics of moxisylyte after oral administration to healthy volunteers. J Pharm Sci. 1993;82:968-71 pubmed
    The pharmacokinetics of moxisylyte in plasma and urine was investigated after oral administration...
  36. Pfeiffer N, Grehn F, Wellek S, Schwenn O. Intraocular thymoxamine or acetylcholine for the reversal of mydriasis. Ger J Ophthalmol. 1994;3:422-6 pubmed
    ..No drug-related side effect was detected. We conclude that thymoxamine can be useful during surgery as an intraocular miotic to reverse mydriasis and can considerably enhance miosis when given in combination with acetylcholine...
  37. Costa P, Bressolle F, Sarrazin B, Mosser J, Galtier M. Pharmacokinetics of moxisylyte in healthy volunteers after intravenous and intracavernous administration. J Pharm Sci. 1993;82:729-33 pubmed
    The concentration-time profiles of metabolites of moxisylyte, an alpha-adrenergic receptor blocking agent, in the plasma of 12 healthy volunteers were investigated after intravenous (iv) and intracavernous (ic) administrations...
  38. al Damluji S, Iveson T, Thomas J, Pendlebury D, Rees L, Besser G. Food-induced cortisol secretion is mediated by central alpha-1 adrenoceptor modulation of pituitary ACTH secretion. Clin Endocrinol (Oxf). 1987;26:629-36 pubmed
    ..We therefore conclude that postprandial cortisol secretion is mediated by central stimulant alpha-1 adrenoceptors modulating pituitary ACTH secretion...
  39. Chapuis N, Brühlmann C, Reist M, Carrupt P, Mayer J, Testa B. The esterase-like activity of serum albumin may be due to cholinesterase contamination. Pharm Res. 2001;18:1435-9 pubmed
    ..The purpose of the present work was to examine this hypothesis...
  40. McKinna H, Stewart Jones J, Edgar D, Turner P. Reversal of tropicamide-induced mydriasis by thymoxamine eye drops. Curr Med Res Opin. 1988;11:1-3 pubmed
    ..5%), but only incompletely that by tropicamide (1.0%). The difference between these effects was statistically significant (p less than 0.025). The thymoxamine eye drops were well tolerated...
  41. Green K, Chapman J, Cheeks L, Hull D. Effects of thymoxamine on corneal endothelium. Lens Eye Toxic Res. 1991;8:1-8 pubmed
    ..1 vs 10.3 microns/h; P less than 0.05). The data suggests that the maximum recommended intracameral concentration of thymoxamine be 0.02% in order to allow a 10-fold safety factor for the corneal endothelium...
  42. Gordon Y, Romanowski E, Harwick J, Berman J, Olsakovsky L, Araullo Cruz T. The effect of alpha blockade on iontophoresis-induced ocular shedding of latent HSV-1 W in different host animals. Curr Eye Res. 1990;9:1007-14 pubmed
    ..We conclude that alpha blockade may alter the reactivation signal that is mediated via the adrenergic system, and that different host factors (as expressed in different species) may play an important role in this process...
  43. Yin N, Jin X, He J, Yin Z. Effects of adrenergic agents on the expression of zebrafish (Danio rerio) vitellogenin Ao1. Toxicol Appl Pharmacol. 2009;238:20-6 pubmed publisher
    ..Thus, our present data indicate that the production of teleost VTG in vivo can be regulated not only by estrogenic agents, but by adrenergic signals as well...
  44. Costa P, Soulie Vassal M, Sarrazin B, Rebillard X, Navratil H, Bali J. Adrenergic receptors on smooth muscle cells isolated from human penile corpus cavernosum. J Urol. 1993;150:859-63 pubmed
    The effect of the alpha-adrenergic blocker moxisylyte was examined on smooth muscle cells isolated from human corpus cavernosum, and compared with that of other adrenergic agents and papaverine...
  45. Costa P, Bressolle F, Mottet N, Rouzier Panis R, Navratil H, Marquer C. Pharmacokinetics of moxisylyte in healthy volunteers after intravenous infusion and intracavernous administration with and without a penile tourniquet. Ther Drug Monit. 1996;18:135-44 pubmed
    The concentration-time profiles of metabolites of moxisylyte (or thymoxamine), an alpha-blocking agent, were investigated in 18 healthy volunteers after intravenous (i.v.) and intracavernous (i.c...
  46. Buvat J, Buvat Herbaut M, Lemaire A, Marcolin G. [Treatment of impotence with intracavernous auto-injections: moxisylyte diminishes the risks compared to papaverine]. Contracept Fertil Sex. 1993;21:173-6 pubmed
    The alpha-blocking agent Moxisylyte was tested in auto-intracavernous injections (auto-ICI) in 72 impotent patients...
  47. Costa P, Bressolle F, Sarrazin B, Mosser J, Navratil H, Galtier M. Moxisylyte plasma kinetics in humans after intracavernous administration. Biopharm Drug Dispos. 1992;13:671-9 pubmed
    ..In this work, the use of an alpha-adrenergic blocking agent, moxisylyte, after intracavernous administration for complete paraplegic patients with erectile impotence is described...
  48. Marquer C, Bressolle F. High-performance liquid chromatographic determination of the conjugate metabolites of moxisylyte in human plasma and urine. J Chromatogr B Biomed Sci Appl. 1997;691:389-96 pubmed
    ..chromatographic methods with fluorescence detection are described for the determination of the metabolites of moxisylyte (4-(2-dimethylaminoethoxy)-5-isopropyl-2-methylphenyl acetate) in human plasma and urine...
  49. Paradisi R, Venturoli S, Capelli M, Spada M, Giambiasi M, Magrini O, et al. Effects of alpha 1-adrenergic blockade on pulsatile luteinizing hormone, follicle-stimulating hormone, and prolactin secretion in polycystic ovary syndrome. J Clin Endocrinol Metab. 1987;65:841-6 pubmed
  50. de Tejada I, Garvey D, Schroeder J, Shelekhin T, Letts L, Fernandez A, et al. Design and evaluation of nitrosylated alpha-adrenergic receptor antagonists as potential agents for the treatment of impotence. J Pharmacol Exp Ther. 1999;290:121-8 pubmed
    ..and rabbit corpus cavernosum strips in organ chambers, the alpha-adrenergic receptor antagonists (alpha-ARAs) moxisylyte and yohimbine and their corresponding nitrosylated compounds, SNO-moxisylyte (NMI-221) and SNO-yohimbine (NMI-..
  51. Zhan G, Toris C, Meza J, Camras C. Unoprostone isopropyl ester darkens iris color in pigmented rabbits with sympathetic denervation. J Glaucoma. 2003;12:383-9 pubmed
    ..Unoprostone isopropyl ester (unoprostone) -induced iris color darkening was evaluated in a rabbit model using a cyclooxygenase inhibitor, an alpha(1)-adrenergic antagonist, and sympathetic denervation...
  52. McIntyre A, Thompson D, Burnham W, Walker E. The effect of alpha-1-adrenoreceptor agonist and antagonist administration on human upper gastrointestinal transit and motility. Aliment Pharmacol Ther. 1992;6:415-26 pubmed
    ..Failure of alpha-1-antagonist administration to alter oro-caecal transit suggests that this pathway is not tonically active, and it is therefore unlikely to play a major role in nutrient passage under normal circumstances...
  53. Duchene P, Bernouillet C, Bromet Petit M, Mosser J, Feniou C, Gaudin D, et al. Metabolism of 14C-thymoxamine in rat and man. Xenobiotica. 1988;18:919-28 pubmed
    ..4. These two major metabolites of thymoxamine in man and rat have been identified and characterized as the sulphate conjugates of desacetyl-thymoxamine and N-monodesmethyl-desacetyl-thymoxamine...
  54. Shah B, Hubbard B, Stewart Jones J, Edgar D, Turner P. Influence of thymoxamine eye-drops on the mydriatic effect of tropicamide and phenylephrine alone and in combination. Ophthalmic Physiol Opt. 1989;9:153-5 pubmed
    ..5% plus phenylephrine 2.5%, however, was not completely reversed by thymoxamine 0.5% over a period of 180 minutes. Phenylephrine, tropicamide and thymoxamine are freely available for use by registered optometrists...
  55. Drago F, Dal Bello A, Marino V, Pisati R, Lodola E, Barbieri P. Evaluation of the effect of thymoxamine solution 0.5% on mydriasis induced by ibopamine solution 1%. Eur J Clin Pharmacol. 1993;44:477-80 pubmed
    ..The pupillary response to thymoxamine was not influenced by the colour of the iris. The tolerability of ibopamine and of thymoxamine was good. No local or systemic adverse events were seen or reported...
  56. Wright M, Skuta G, Drake M, Chang L, Rabbani R, Musch D, et al. Time course of thymoxamine reversal of phenylephrine-induced mydriasis. Arch Ophthalmol. 1990;108:1729-32 pubmed
    ..6 vs 2.8 hours, respectively (P = .0046). After constriction to baseline pupillary diameter had been achieved, no patients experienced a rebound dilation...
  57. Aldana I, González Peñas E, Fos D, Bruseghini L, Esteras A, Ceppi Monti N, et al. Pharmacokinetics of thymoxamine in rabbits after ophthalmic and intravenous administration. Eur J Drug Metab Pharmacokinet. 1994;19:79-83 pubmed
    ..In fact, considering the detection limit of the method, the plasma levels of deacetylthymoxamine are certainly more than 100-times lower than those observed with intravenous treatment...
  58. Marquer C, Bressolle F. Moxisylyte: a review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in impotence. Fundam Clin Pharmacol. 1998;12:377-87 pubmed
    b>Moxisylyte is a competitive noradrenaline antagonist, acting preferentially on post-synaptic alpha-1 adrenoceptors...
  59. Buvat J, Costa P, Morlier D, Lecocq B, Stegmann B, Albrecht D. Double-blind multicenter study comparing alprostadil alpha-cyclodextrin with moxisylyte chlorhydrate in patients with chronic erectile dysfunction. J Urol. 1998;159:116-9 pubmed
    We compared the efficacy and safety of alprostadil alpha-cyclodextrin and moxisylyte chlorhydrate to induce erections adequate for sexual intercourse in a prospective, randomized, parallel double-blind study in patients with erectile ..
  60. Arvis G, Rivet G, Schwent B. [Prolonged use of moxisylyte chlorhydrate (Icavex) by intracavernous self-injections in the treatment of impotence. Evaluation of long-term tolerance]. J Urol (Paris). 1996;102:151-6 pubmed
    b>Moxisylyte chlorhydrate is a selective alpha-blocker of the post-synaptic alpha 1-adrenoreceptors. It has been used since 1992 for self-injections to induce erection...
  61. Navratil H, Costa P, Louis J, Andro M, Saur P. [Effectiveness of and tolerance to intracavernous injection of moxisylyte in patients with erectile dysfunction: effect/dose relationship versus placebo]. Prog Urol. 1995;5:690-6 pubmed
    The authors investigated the optima dose (efficacy and safety) of moxisylyte, an alpha-blocking agent, in a double-blind placebo-controlled crossover study in 30 patients...
  62. Gilmartin B, Amer A, Ingleby S. Reversal of tropicamide mydriasis with single instillations of pilocarpine can induce substantial pseudo-myopia in young adults. Ophthalmic Physiol Opt. 1995;15:475-9 pubmed
    ..Tropicamide induced a mean increase in pupil area from 25 to 50 mm2 after 22 min which was generally sustained over the 90 min period and was enhanced for the lower pigment groups.(ABSTRACT TRUNCATED AT 250 WORDS)..
  63. Rosenfield M, Gilmartin B, Cunningham E, Dattani N. The influence of alpha-adrenergic agents on tonic accommodation. Curr Eye Res. 1990;9:267-72 pubmed
    ..Furthermore in all conditions TA increased by approximately 0.25D while the subject sat passively in darkness. The data indicates that alpha-adrenergic innervation alters the closed-loop accommodative response independently of TA...
  64. Moussa C, Houziaux P, Danree B, Azerad R. Microbial models of mammalian metabolism. Fungal metabolism of phenolic and nonphenolic p-cymene-related drugs and prodrugs. I. Metabolites of thymoxamine. Drug Metab Dispos. 1997;25:301-10 pubmed
    ..A similar glucosylation reaction was observed when thymohydroquinone 10 was incubated with A. elegans. Several strains were able to produce transiently thymohydroquinone from DAT-N-oxide 5, possibly through a beta-elimination mechanism...
  65. Combes T, Beguin A, Coulomb Y, Barouti H, Costa P. [Changes in urethral pressure after intravenous injection of moxisylyte hydrochloride in urethral instability in women. Preliminary results]. Prog Urol. 1995;5:49-57 pubmed
    To study the action of an alpha blocker, Moxisylyte hydrochloride, during an intravenous test on the course of urethral pressure in women with urethral instability associated with urethral hypertonia.
  66. Grigg M, Nicolaides A, Papadakis K, Wolfe J. The efficacy of thymoxamine in primary Raynaud's phenomenon. Eur J Vasc Surg. 1989;3:309-13 pubmed
    ..01). Absolute digital temperatures and maximum rewarming rates were increased and the length of the latent period reduced (P less than 0.001). These effects were more pronounced with thymoxamine 80 mg than with thymoxamine 40 mg...