technetium tc 99m exametazime


Summary: A gamma-emitting RADIONUCLIDE IMAGING agent used in the evaluation of regional cerebral blood flow and in non-invasive dynamic biodistribution studies and MYOCARDIAL PERFUSION IMAGING. It has also been used to label leukocytes in the investigation of INFLAMMATORY BOWEL DISEASES.

Top Publications

  1. Colloby S, Fenwick J, Williams E, Paling S, Lobotesis K, Ballard C, et al. A comparison of (99m)Tc-HMPAO SPET changes in dementia with Lewy bodies and Alzheimer's disease using statistical parametric mapping. Eur J Nucl Med Mol Imaging. 2002;29:615-22 pubmed
    ..In conclusion, we found evidence of frontal and parietal hypoperfusion in both AD and DLB, while temporal perfusion deficits were observed exclusively in AD and parieto-occipital deficits in DLB...
  2. Seedat S, Warwick J, van Heerden B, Hugo C, Zungu Dirwayi N, Van Kradenburg J, et al. Single photon emission computed tomography in posttraumatic stress disorder before and after treatment with a selective serotonin reuptake inhibitor. J Affect Disord. 2004;80:45-53 pubmed
    ..However, the neural substrates of PTSD remain poorly understood and the effect of selective serotonin reuptake inhibition on regional cerebral activity is deserving of further investigation...
  3. Kaya G, Ertay T, Tuna B, Bekis R, Tasci C, Sayit E, et al. Technetium-99m hexamethylpropylene amine oxime lung scintigraphy findings in low-dose amiodarone therapy. Lung. 2006;184:57-61 pubmed
    ..Both scintigraphic studies and histopathologic examinations showed nonspecific changes. Longitudinal studies investigating Tc-99m HMPAO lung uptake may be planned in patients carrying risk factors for AD-induced lung toxicity...
  4. de Vries E, Roca M, Jamar F, Israel O, Signore A. Guidelines for the labelling of leucocytes with (99m)Tc-HMPAO. Inflammation/Infection Taskgroup of the European Association of Nuclear Medicine. Eur J Nucl Med Mol Imaging. 2010;37:842-8 pubmed publisher
    ..This protocol includes quality control and safety procedures and is in accordance with current European Union regulations and International Atomic Energy Agency recommendations...
  5. Akkaş B, Gokcora N, Atasever T, Yetkin I. The use of technetium-99m hexamethylpropylene amine oxime lung scintigraphy in the detection of subclinical lung injury in patients with noninsulin-dependent diabetes mellitus. Nucl Med Commun. 2011;32:1179-84 pubmed publisher
  6. Durak H, Kilinc O, Ertay T, Ucan E, Kargi A, Kaya G, et al. Tc-99m-HMPAO uptake by bronchoalveolar cells. Ann Nucl Med. 2003;17:107-13 pubmed
    ..Glutathione concentration and oxido-reductive state of the epithelial lining fluid and BAL cells may influence the lung uptake of Tc-99m-HMPAO...
  7. Hang L, Hsu W, Tsai J, Jim Y, Lin C, Kao A. A pilot trial of quantitative Tc-99m HMPAO and Ga-67 citrate lung scans to detect pulmonary vascular endothelial damage and lung inflammation in patients of collagen vascular diseases with active diffuse infiltrative lung disease. Rheumatol Int. 2004;24:153-6 pubmed
    ..However, the relationships between HRCT scoring, GUI, and L/L ratio in patients with collagen vascular diseases and active ILD are not significant...
  8. Chang C, Liu F, Hsu W, Lin C, Lee C, Kao A. Usefulness of quantitative Tc-99m HMPAO and Ga-67 citrate lung scans in detecting pulmonary vascular endothelium damage and lung inflammation in patients with systemic lupus erythematosus: a preliminary report. Rheumatol Int. 2003;23:178-81 pubmed
    ..In conclusion, the change in pulmonary vascular endothelium damage in SLE may be unrelated to the clinical presentation or chest X-ray findings, and its degree is not related to the severity of pulmonary inflammation...
  9. Chang C, Wu H, Tsai J, Lin C, Lee C, Kao A. Usefulness of technetium-99m hexamethylpropylene amine oxime lung scan to detect subclinical lung injury in patients with chronic renal failure. Lung. 2003;181:97-101 pubmed
    ..In addition, Tc-99m HMPAO lung scan has the potential to be a sensitive, objective and noninvasive method to detect subclinical lung injury of CRF patients on HD, which is different from the traditional studies such as CXR or PFT...

More Information

Publications101 found, 100 shown here

  1. Shiau Y, Liu F, Tsai J, Wang J, Ho S, Kao A. Usefulness of technetium-99m hexamethylpropylene amine oxime lung scan to detect inhalation lung injury of patients with pulmonary symptoms/signs but negative chest radiograph and pulmonary function test findings after a fire accident--a preliminary . Ann Nucl Med. 2003;17:435-8 pubmed
    ..In this study, we employed technetium-99m hexamethylpropylene amine oxime (99mTc HMPAO) lung scan to detect inhalation lung injury of patients after a fire accident...
  2. Sundström T, Elgh E, Larsson A, Nasman B, Nyberg L, Riklund K. Memory-provoked rCBF-SPECT as a diagnostic tool in Alzheimer's disease?. Eur J Nucl Med Mol Imaging. 2006;33:73-80 pubmed
    ..e. memory-provoked rCBF-SPECT (MP-SPECT)...
  3. Kemp P, Hoffmann S, Holmes C, Bolt L, Ward T, Holmes R, et al. The contribution of statistical parametric mapping in the assessment of precuneal and medial temporal lobe perfusion by 99mTc-HMPAO SPECT in mild Alzheimer's and Lewy body dementia. Nucl Med Commun. 2005;26:1099-106 pubmed
  4. Slosman D, Ludwig C, Zerarka S, Pellerin L, Chicherio C, De Ribaupierre A, et al. Brain energy metabolism in Alzheimer's disease: 99mTc-HMPAO SPECT imaging during verbal fluency and role of astrocytes in the cellular mechanism of 99mTc-HMPAO retention. Brain Res Brain Res Rev. 2001;36:230-40 pubmed
    ..In particular, these observations suggest a key role of astrocytes in the signal detected with the imaging procedure, which is altered in the Alzheimer's cohort subjected to the verbal fluency activation task...
  5. Capa Kaya G, Bekis R, Kirimca F, Ertay T, Kargi A, Gure A, et al. Use of technetium-99m HMPAO scintigraphy for the detection of amiodarone lung toxicity in a rabbit model. Eur J Nucl Med. 2001;28:346-50 pubmed
    ..According to our findings, 99mTc-HMPAO lung uptake is correlated with AD dose. 99mTc-HMPAO lung imaging can demonstrate AD-induced lung injury...
  6. Zerarka S, Pellerin L, Slosman D, Magistretti P. Astrocytes as a predominant cellular site of (99m)Tc-HMPAO retention. J Cereb Blood Flow Metab. 2001;21:456-68 pubmed
    ..In addition, the data also suggest that specific alterations in glial cell metabolism could explain flow-independent changes in (99m)Tc-HMPAO retention in the brain as observed by SPECT in some pathologies...
  7. Ak I, Vardereli E, Durak B, Gulbas Z, Basaran N, Stokkel M, et al. Labeling of mixed leukocytes with (99m)Tc-HMPAO causes severe chromosomal aberrations in lymphocytes. J Nucl Med. 2002;43:203-6 pubmed
    ..Cytotoxicity studies have indicated that intracellular labeling of leukocytes with (111)In compounds may have severe detrimental effects on the cells...
  8. Uzuner N, Ak I, Gücüyener D, Asil T, Vardareli E, Ozdemir G. Cerebral hemodynamic patterns with technetium Tc 99m exametazime single photon emission computed tomography and transcranial Doppler sonography: a validation study using visual stimulation. J Ultrasound Med. 2002;21:955-9 pubmed
    ..To assess whether a correlation between perfusion changes to visual stimulus on the bilateral occipital areas and blood flow velocity changes to visual stimulus in both posterior cerebral arteries is present...
  9. Piera C, Vazquez A, Hernandez M, Plancha M, Ruiz A, Mateos J, et al. [Fast method of labelling leukocytes with 99mTc HM PAO]. Rev Esp Med Nucl. 2002;21:343-8 pubmed
    ..To modify the method of labelling leukocytes with 99mTc HM-PAO by centrifuging 15 minutes at low gravity (g) instead of sedimentation at a variable time (30-90 minutes) to obtain leukocytic rich plasma (LRP)...
  10. Lucey J, Costa D, Busatto G, Pilowsky L, Marks I, Ell P, et al. Caudate regional cerebral blood flow in obsessive-compulsive disorder, panic disorder and healthy controls on single photon emission computerised tomography. Psychiatry Res. 1997;74:25-33 pubmed
    ..The data suggest functional involvement of the right caudate nucleus is present in OCD...
  11. Elgh E, Sundström T, Nasman B, Ahlström R, Nyberg L. Memory functions and rCBF (99m)Tc-HMPAO SPET: developing diagnostics in Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2002;29:1140-8 pubmed
    ..The correlation between rCBF ratio and level of episodic memory performance suggests that abnormalities in rCBF pattern underlie impaired episodic memory functioning in AD...
  12. Varrone A, Pappata S, Caracò C, Soricelli A, Milan G, Quarantelli M, et al. Voxel-based comparison of rCBF SPET images in frontotemporal dementia and Alzheimer's disease highlights the involvement of different cortical networks. Eur J Nucl Med Mol Imaging. 2002;29:1447-54 pubmed
    ..Furthermore, they highlight the networks that are more specifically impaired in these disorders and that could be implicated in the emotional-behavioural and cognitive disturbances that characterise FTD and AD respectively...
  13. Akhmedov S, Babokin V, Riabov V, Suslova T, Chernov V, Sazonova S, et al. [Clinical experience of the use of autologous mononuclear bone marrow cells in patients with ischemic heart disease and dilated cardiomyopathy]. Kardiologiia. 2006;46:10-4 pubmed
    ..Accumulation of labeled cells after 24 hours was 1.6+/-0.001%. After 6 months parameters of intracardiac hemodynamics and transitory myocardial perfusion defects improved significantly in all patients with ischemic heart disease. ..
  14. Kim H, Na S, Oh S, Jung B, Lee S, Chang J, et al. Usefulness of adding SPECT/CT to 99mTc-hexamethylpropylene amine oxime (HMPAO)-labeled leukocyte imaging for diagnosing prosthetic joint infections. J Comput Assist Tomogr. 2014;38:313-9 pubmed publisher
  15. Soriani Lefèvre M, Hannequin D, Bakchine S, Menard J, Manrique A, Hitzel A, et al. Evidence of bilateral temporal lobe involvement in primary progressive aphasia: a SPECT study. J Nucl Med. 2003;44:1013-22 pubmed
    ..Moreover, in these regions, morphologic abnormalities are preceded by perfusion abnormalities. Finally, our results show that large left temporal dysfunction occurs in patients with LS disorders. ..
  16. Takasawa M, Murase K, Oku N, Kawamata M, Nagayoshi M, Imaizumi M, et al. Spectral analysis of 99mTc-HMPAO for estimating cerebral blood flow: a comparison with H2(15)O PET. Ann Nucl Med. 2004;18:243-9 pubmed
    ..The SA method should be especially useful for activation studies involving pharmacological intervention and/or clinical cases with an increased CBF. ..
  17. Llorens V, Gabilondo I, Gomez Esteban J, Agundez M, Mendibe M, Bergara J, et al. Abnormal multifocal cerebral blood flow on Tc-99m HMPAO SPECT in a patient with anti-NMDA-receptor encephalitis. J Neurol. 2010;257:1568-9 pubmed publisher
  18. Nagao M, Sugawara Y, Ikeda M, Fukuhara R, Hokoishi K, Murase K, et al. Heterogeneity of cerebral blood flow in frontotemporal lobar degeneration and Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2004;31:162-8 pubmed
    ..7% and a specificity of 93.8%. Anterior FD and the ratio of anterior to posterior FD may be useful in distinguishing FTLD from AD. ..
  19. Kim W, Jeong M, Kim S, Park W, Park O, Kim J, et al. A novel method of brachytherapy using local delivery of 99mTc-HMPAO for coronary stent restenosis. Korean J Intern Med. 2004;19:179-88 pubmed
    ..2%). Local delivery of 99mTc-HMPAO, a novel radiotherapy, can be used safely and effectively for coronary stent restenosis. ..
  20. Poullis A, Irwin A, Dearing M, Gordon C, Britten A, Heenan S, et al. Repeat planar white cell scanning to monitor short-term therapy of active inflammatory bowel disease: a methodological study and comparison with clinical scores and novel inflammatory markers. Eur J Gastroenterol Hepatol. 2006;18:607-14 pubmed
    ..45, P=0.05). Non-invasive white cell scanning is a feasible and objective method to monitor the anti-inflammatory efficacy of treatments for active inflammatory bowel disease. ..
  21. de Boorder M, van der Grond J, van Dongen A, Klijn C, Jaap Kappelle L, van Rijk P, et al. Spect measurements of regional cerebral perfusion and carbondioxide reactivity: correlation with cerebral collaterals in internal carotid artery occlusive disease. J Neurol. 2006;253:1285-91 pubmed
    ..Regional assessment of cerebral perfusion and VMR with SPECT demonstrated the heterogeneity of cerebral hemodynamics and the importance of collateral flow via the anterior circle of Willis. ..
  22. Beato Fernandez L, Rodriguez Cano T, Garcia Vilches I, Garcia Vicente A, Poblete Garcia V, Castrejon A, et al. Changes in regional cerebral blood flow after body image exposure in eating disorders. Psychiatry Res. 2009;171:129-37 pubmed publisher
    ..Functional abnormalities in AN might be related to the storage of a distorted prototypical image of the body in the left parietal lobe. ..
  23. Hsu H, Fu Y, Tsai S, Yen R, Hwang B. Usefulness of Tc-99m HMPAO-labeled WBC heart scan to predict impaired ventricular function and coronary artery dilation in children with Kawasaki disease. Int J Cardiol. 2003;92:65-9 pubmed
    ..9%, respectively. Our findings suggest that significant carditis determined by Tc-99m HMPAO-labeled WBC heart scan can accurately predict impaired ventricular function and coronary artery dilation. ..
  24. Kuo P, Cheng D, Sadar R. Diagnosis of septic joint in an immunosuppressed patient by twenty-four hour delayed imaging with Tc-99m HMPAO labeled white blood cell scan. Clin Nucl Med. 2005;30:808-9 pubmed
  25. Kang J, Lee J, Kang H, Lee H, Kim Y, Jeon H, et al. Regional cerebral blood flow abnormalities associated with apathy and depression in Alzheimer disease. Alzheimer Dis Assoc Disord. 2012;26:217-24 pubmed publisher
    ..We suggest that this finding may indicate that apathy and depression in AD patients involve distinct functional circuits. ..
  26. Leonhardt G, de Greiff A, Weber J, Ludwig T, Wiedemayer H, Forsting M, et al. Brain perfusion following single seizures. Epilepsia. 2005;46:1943-9 pubmed
  27. Pavel D, Jobe T, Devore Best S, Davis G, Epstein P, Sinha S, et al. Viewing the functional consequences of traumatic brain injury by using brain SPECT. Brain Cogn. 2006;60:211-3 pubmed
    ..The critical factor for Brain SPECT's clinical relevance is a carefully designed technical protocol, including displays which should enable a comprehensive description of the patterns found, in a user friendly mode. ..
  28. Tae W, Joo E, Han S, Lee K, Hong S. CBF changes in drug naive juvenile myoclonic epilepsy patients. J Neurol. 2007;254:1073-80 pubmed
    ..Our results suggest that abnormal neural networks in the thalamus, hippocampus, brainstem and cerebellum are associated with JME. ..
  29. Sole A, Spriet M, Padgett K, Vaughan B, Galuppo L, Borjesson D, et al. Distribution and persistence of technetium-99 hexamethyl propylene amine oxime-labelled bone marrow-derived mesenchymal stem cells in experimentally induced tendon lesions after intratendinous injection and regional perfusion of the equine distal lim. Equine Vet J. 2013;45:726-31 pubmed publisher
    ..a. RLP. The i.a. RLP appears more advantageous than the i.v. RLP in terms of distribution and uptake. However, the described i.a. technique produced arterial thrombosis and thus cannot currently be recommended for clinical use. ..
  30. Adinoff B, Devous M, Cooper D, Best S, Chandler P, Harris T, et al. Resting regional cerebral blood flow and gambling task performance in cocaine-dependent subjects and healthy comparison subjects. Am J Psychiatry. 2003;160:1892-4 pubmed
    ..Resting anterior cingulate and dorsolateral prefrontal cortex rCBF is significantly related to decision making, as assessed by the Gambling Task. ..
  31. Ozkiris A, Evereklioglu C, Kula M, Somdaş M, Erkilic K, Coskun A. Tc-99m HMPAO brain SPECT in linear nevus sebaceous syndrome. Ann Nucl Med. 2003;17:703-6 pubmed
    ..Tc-99m HMPAO brain SPECT may be more useful for revealing absent or decreased perfusion areas of brain lesions than MRI in LNSS. ..
  32. Tabuenca Dopico O, Gutiérrez Mendiguchía C, Lorenzo González J, Cimas Hernando I. [Does brain blood flow HMPAO SPECT withhold the vascular etiopathogenic theory of transient global amnesia?]. Rev Neurol. 2004;39:719-23 pubmed
    ..Several precipitating factors have been reported. Conventional neuroimaging scans usually are negative. Different etiopathogenic theories have been postulated but the vascular etiology is the most commonly accepted...
  33. Almer S, Granerus G, Ström M, Olaison G, Bonnet J, Lemann M, et al. Leukocyte scintigraphy compared to intraoperative small bowel enteroscopy and laparotomy findings in Crohn's disease. Inflamm Bowel Dis. 2007;13:164-74 pubmed
    ..Leukocyte scintigraphy reliably detects small bowel inflammation in Crohn's disease. It gives additional information on the presence of inflammatory lesions in a fraction of patients planned for surgery. ..
  34. Spieth M, Gauger B. Gallium uptake in complicated pancreatitis. AJR Am J Roentgenol. 2003;180:1177; author reply 1177-8 pubmed
  35. Gardner A, Pagani M, Beier H, Jacobsson H, Larsson S, Hällström T. 99mTc-HMPAO distribution at SPECT is associated with succinate-cytochrome c reductase (SCR) activity in subjects with psychiatric disorders. Nucl Med Biol. 2004;31:277-82 pubmed
    ..The negative relationship between (99m)Tc-HMPAO uptake and SCR activity may be due to redox state alterations influencing fixation of the radiopharmaceutical. ..
  36. Mirahmadi N, Babaei M, Vali A, Daha F, Kobarfard F, Dadashzadeh S. 99mTc-HMPAO-labeled liposomes: an investigation into the effects of some formulation factors on labeling efficiency and in vitro stability. Nucl Med Biol. 2008;35:387-92 pubmed publisher
  37. Kohn Y, Freedman N, Lester H, Krausz Y, Chisin R, Lerer B, et al. Cerebral perfusion after a 2-year remission in major depression. Int J Neuropsychopharmacol. 2008;11:837-43 pubmed publisher
    ..These findings suggest that perfusion increases in parieto/cerebellar regions may be involved in acute response to treatment whereas increases in frontal regions may be related to its consolidation. ..
  38. Nagamachi S, Wakamatsu H, Kiyohara S, Fujita S, Futami S, Tamura S, et al. Usefulness of rCBF analysis in diagnosing Parkinson's disease: supplemental role with MIBG myocardial scintigraphy. Ann Nucl Med. 2008;22:557-64 pubmed publisher
    ..In the differential diagnosis between PD and PS, although its usefulness might be limited, analysis of rCBF in the occipital lobe added to (123)I-MIBG myocardial imaging can be recommended. ..
  39. Yoon H, Cheon S, Jeong Y, Kang D. Correlated regions of cerebral blood flow with clinical parameters in Parkinson's disease; comparison using 'Anatomy' and 'Talairach Daemon' software. Ann Nucl Med. 2012;26:164-74 pubmed publisher
    ..7 of SPM8 toolbox, using the cyto-architectonic probability maps, assigned the anatomical name by percentage value of the probability. ..
  40. Björkstén K, Ekberg S, Säfström P, Dige N, Granerus G. A computerized human reference brain for rCBF/SPET technetium-99m exametazime (HMPAO) investigation of elderly. Clin Physiol Funct Imaging. 2004;24:196-204 pubmed
    ..Statistical multifactorial analysis of parameters used for acquisition and data processing is possible. ..
  41. Silva S, Sousa A, Haddad A, Azevedo J, Soares V, Peixoto C, et al. Autologous bone-marrow mononuclear cell transplantation after acute myocardial infarction: comparison of two delivery techniques. Cell Transplant. 2009;18:343-52 pubmed publisher
    ..BMMNC retention by damaged heart tissue was apparently higher when the anterograde approach was used. Further studies are required to confirm these initial data. ..
  42. Kollaros N, Theodorakos A, Manginas A, Kitziri E, Katsikis A, Cokkinos D, et al. Bone marrow stem cell adherence into old anterior myocardial infarction: a scintigraphic study using Tl-201 and Tc-99m-HMPAO. Ann Nucl Med. 2012;26:228-33 pubmed publisher
    ..Tc-99m-HMPAO labeling of SCs is a reliable method for cell monitoring after ICI in nonviable myocardium after an anterior MI. ..
  43. Liu F, Shian Y, Huang W, Kao C. Usefulness of technetium-99m hexamethylpropylene amine oxime lung scan to detect sub-clinical lung injury of patients with breast cancer after chemotherapy. Anticancer Res. 2003;23:3505-7 pubmed
  44. Lee J, Kang W, Lee D, Lee J, Hwang H, Kim K, et al. Diagnostic performance of 18F-FDG PET and ictal 99mTc-HMPAO SPET in pediatric temporal lobe epilepsy: quantitative analysis by statistical parametric mapping, statistical probabilistic anatomical map, and subtraction ictal SPET. Seizure. 2005;14:213-20 pubmed
    ..SPM analysis of PET or ictal SPET could be used as an aid to visual assessment. Moreover, SISCOM was equal visual assessment of ictal SPET images in terms of lesion localizations. ..
  45. Kamiya R, Ogawa K. Aperture correction with an asymmetrically trimmed Gaussian weight in SPECT with a fan-beam collimator. Ann Nucl Med. 2013;27:661-8 pubmed publisher
    ..Our proposed aperture correction method with the asymmetrically trimmed Gaussian weighting function was effective in improving the spatial resolution of SPECT images acquired with the fan-beam collimator. ..
  46. Vasanawala M, Goris M. Positively labeled white blood cell scan with eosinophilia and absence of infection. Clin Nucl Med. 2003;28:389-91 pubmed
    ..9% lymphocytes, and 22.2% eosinophils). In the labeling of the leukocyte moiety, a higher presence of any leukocyte subpopulation will modify the biodistribution and thus the image interpretation. ..
  47. Vanninen E, Kuikka J, Äikiä M, Kononen M, Vanninen R. Heterogeneity of cerebral blood flow in symptomatic patients undergoing carotid endarterectomy. Nucl Med Commun. 2003;24:893-900 pubmed
    ..The CBF heterogeneity index after acetazolamide injection is a sensitive marker of the haemodynamic consequences of carotid artery stenosis and its operative treatment. ..
  48. Igarashi H, Hamamoto M, Yamaguchi H, Ookubo S, Nagashima J, Nagayama H, et al. Cerebral blood flow index image as a simple indicator for the fate of acute ischemic lesion. Acta Neurochir Suppl. 2003;86:241-6 pubmed
    ..CBF index well correlated to SPECT delivered CBF. CBF index images can accurately predict final infarct volume. Evaluating CBF index images together with DWI can guide the initial assessment in the acute stage of cerebral ischemia. ..
  49. Banzo I, Quirce R, Martinez Rodriguez I, Jimenez Bonilla J, Portilla Quattrociocchi H, Medina Quiroz P, et al. [Molecular neuroimaging in the study of cognitive impairment: contribution of the cerebral blood flow SPECT with 99mTc-HMPAO and 18F-FDG PET/CT scan]. Rev Esp Med Nucl. 2011;30:301-6 pubmed publisher
    ..In patients with a normal cerebral blood flow SPECT, brain glucose cerebral hypometabolism can be detected. In some patients, the extension of FDG hypometabolism is more pronounced than that corresponding to the hypoperfusion area. ..
  50. Duran F, Zampieri F, Bottino C, Buchpiguel C, Busatto G. Voxel-based investigations of regional cerebral blood flow abnormalities in Alzheimer's disease using a single-detector SPECT system. Clinics (Sao Paulo). 2007;62:377-84 pubmed
    ..This suggests the potential usefulness of using SPM for the analysis of data acquired with single-detector SPECT systems, despite the limited sensitivity and spatial resolution of such equipment. ..
  51. Kobayashi M, Matsunari I, Nishi K, Mizutani A, Miyazaki Y, Ogai K, et al. Simultaneous acquisition of (99m)Tc- and (123)I-labeled radiotracers using a preclinical SPECT scanner with CZT detectors. Ann Nucl Med. 2016;30:263-71 pubmed publisher
  52. Murase K, Nagayoshi M, Uenishi Y, Kawamata M, Yamazaki Y, Takasawa M, et al. Extraction of arterial input function for measurement of brain perfusion index with 99mTc compounds using fuzzy clustering. Nucl Med Commun. 2004;25:299-303 pubmed
    ..These results suggest that the FCM clustering method appears to be useful for the measurement of BPI, because it allows a reliable and objective determination of AIF...
  53. Fulgenzi A, Casati R, Colombo F, Gasparini M, Ferrero E, Bondanza A, et al. Distribution of 99mTc-labeled lymphocytes in control and inflamed rats. Nucl Med Biol. 2004;31:631-8 pubmed
    ..The same method was also successfully used to in vivo study the homing of total blood lymphocytes obtained from inflamed rats...
  54. Benabarre A, Vieta E, Martin F, Lomena F, Martinez Aran A, Colom F, et al. Clinical value of 99mTc-HMPAO SPECT in depressed bipolar I patients. Psychiatry Res. 2004;132:285-9 pubmed
    ..The patients with visible SPECT abnormalities had significantly higher scores on the Hamilton Rating Scale for Depression (HDRS)...
  55. Alves T, Rays J, Fraguas R, Wajngarten M, Meneghetti J, Prando S, et al. Localized cerebral blood flow reductions in patients with heart failure: a study using 99mTc-HMPAO SPECT. J Neuroimaging. 2005;15:150-6 pubmed
  56. Caroli A, Testa C, Geroldi C, Nobili F, Barnden L, Guerra U, et al. Cerebral perfusion correlates of conversion to Alzheimer's disease in amnestic mild cognitive impairment. J Neurol. 2007;254:1698-707 pubmed
    ..Aim of this study was to find cerebral perfusion correlates of conversion to dementia in patients with amnestic MCI...
  57. Cavallin L, Axelsson R, Wahlund L, Oksengard A, Svensson L, Juhlin P, et al. Voxel-based correlation between coregistered single-photon emission computed tomography and dynamic susceptibility contrast magnetic resonance imaging in subjects with suspected Alzheimer disease. Acta Radiol. 2008;49:1154-61 pubmed publisher
    ..Neuroimaging techniques such as magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT) could be valuable in the differential diagnosis of Alzheimer disease, as well as in assessing prognosis...
  58. Kreisler A, Defebvre L, Lecouffe P, Duhamel A, Charpentier P, Steinling M, et al. Corticobasal degeneration and Parkinson's disease assessed by HmPaO SPECT: the utility of factorial discriminant analysis. Mov Disord. 2005;20:1431-8 pubmed
    ..We believe that this semiautomatic classification may be a precious tool for reinforcing the current clinical differential diagnosis of CBD and PD...
  59. Kmiec T, Kaminska A, Jozwiak S, Kuczyński D. [Usefulness of cerebral SPECT in the children with migraine]. Neurol Neurochir Pol. 2005;39:S36-41 pubmed
    ..In all these 19 cases we observed localization of hypoperfused foci in SPECT imaging matched with the side of migraine pain...
  60. Stathaki M, Koutroubakis I, Koukouraki S, Karmiris K, Moschandreas J, Kouroumalis E, et al. Active inflammatory bowel disease: head-to-head comparison between 99mTc-hexamethylpropylene amine oxime white blood cells and 99mTc(V)-dimercaptosuccinic acid scintigraphy. Nucl Med Commun. 2008;29:27-32 pubmed
  61. Kato H, Yoshikawa T, Oku N, Imaizumi M, Takasawa M, Kimura Y, et al. Statistical parametric analysis of cerebral blood flow in vascular dementia with small-vessel disease using Tc-HMPAO SPECT. Cerebrovasc Dis. 2008;26:556-62 pubmed publisher
    ..It still remains unclear, however, whether SVD may present with localized regional cerebral blood flow (rCBF) changes. We aimed to clarify the local rCBF changes associated with dementia in patients with early-stage SVD...
  62. Song Y, Oh S, Kim Y, Kim S, Wang K, Lee D. Hemodynamic improvement of anterior cerebral artery territory perfusion induced by bifrontal encephalo(periosteal) synangiosis in pediatric patients with moyamoya disease: a study with brain perfusion SPECT. Ann Nucl Med. 2012;26:47-57 pubmed publisher
  63. Fountoulakis K, Iacovides A, Gerasimou G, Fotiou F, Ioannidou C, Bascialla F, et al. The relationship of regional cerebral blood flow with subtypes of major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28:537-46 pubmed
    ..The aim of the present study was to search for differences between subtypes of major depression with the use of single photon emission tomography...
  64. Browndyke J, Tucker K, Woods S, Beauvals J, Cohen R, Gottschalk P, et al. Examining the effect of cerebral perfusion abnormality magnitude on cognitive performance in recently abstinent chronic cocaine abusers. J Neuroimaging. 2004;14:162-9 pubmed
    ..While perfusion abnormalities have been shown to relate to cognitive deficits in this substance abuse population, the relationship between cognitive performance and the magnitude of perfusion abnormality has yet to be fully determined...
  65. Döbert N, Pantel J, Frolich L, Hamscho N, Menzel C, Grünwald F. Diagnostic value of FDG-PET and HMPAO-SPET in patients with mild dementia and mild cognitive impairment: metabolic index and perfusion index. Dement Geriatr Cogn Disord. 2005;20:63-70 pubmed
  66. Ortapamuk H, Naldoken S. Brain perfusion abnormalities in chronic obstructive pulmonary disease: comparison with cognitive impairment. Ann Nucl Med. 2006;20:99-106 pubmed
  67. McNeill R, Sare G, Manoharan M, Testa H, Mann D, Neary D, et al. Accuracy of single-photon emission computed tomography in differentiating frontotemporal dementia from Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2007;78:350-5 pubmed
    ..Confirmation is often sought from neuroimaging, including single-photon emission computed tomography (SPECT). Most previous SPECT studies lack pathological validation...
  68. Yao W, Pan H, Yang Y, Chou Y, Wang S, Yu C, et al. Reduced frontal perfusion in depressed postmenopausal women: a SPECT study with WCST. Maturitas. 2008;59:83-90 pubmed
    ..To investigate frontal cerebral blood flow (CBF) in depressed postmenopausal women and its relation to cognitive function and the severity of depressive symptoms...
  69. Yoshimura S, Kitajima H, Enomoto Y, Yamada K, Iwama T. Staged angioplasty for carotid artery stenosis to prevent postoperative hyperperfusion. Neurosurgery. 2009;64:ons122-8; discussion ons128-9 pubmed publisher
    ..This report describes the clinical efficacy of staged angioplasty (SAP) for carotid artery stenosis to prevent HP after carotid revascularization...
  70. Caobelli F, Panarotto M, Andreoli F, Ravelli A, De Agostini A, Giubbini R. Is 99mTc-HMPAO granulocyte scan an alternative to endoscopy in pediatric chronic inflammatory bowel disease (IBD)?. Eur J Pediatr. 2011;170:51-7 pubmed publisher
  71. van Eerd J, Laverman P, Oyen W, Harris T, Edwards D, Ellars C, et al. Imaging of experimental colitis with a radiolabeled leukotriene B4 antagonist. J Nucl Med. 2004;45:89-93 pubmed
    ..Imaging characteristics of the (111)In-labeled LTB(4) antagonist (DPC11870) were compared with those of (18)F-FDG and (99m)Tc-HMPAO-granulocytes in a rabbit model of experimental colitis...
  72. Schibli R, Dumas C, Petrig J, Spadola L, Scapozza L, Garcia Garayoa E, et al. Synthesis and in vitro characterization of organometallic rhenium and technetium glucose complexes against Glut 1 and hexokinase. Bioconjug Chem. 2005;16:105-12 pubmed
    ..The current results seem to preclude the use of these compounds as [18F]-FDG surrogates primarily due to the low cellular uptake via Glut1...
  73. Preul C, Lohmann G, Hund Georgiadis M, Guthke T, von Cramon D. Morphometry demonstrates loss of cortical thickness in cerebral microangiopathy. J Neurol. 2005;252:441-7 pubmed
    ..To evaluate the role of MR morphometry in the characterization of cerebral microangiopathy (CMA) in relation to clinical and neuropsychological impairment...
  74. Yin Y, Shuke N, Okizaki A, Sato J, Aburano T, Li Y, et al. Cerebral activation during withholding urine with full bladder in healthy men using 99mTc-HMPAO SPECT. J Nucl Med. 2006;47:1093-8 pubmed
    ..The aim of this study was to identify the brain areas that control urinary continence in healthy men by 99mTc-hexamethylpropyleneamine oxime (99mTc-HMPAO) SPECT...
  75. Nobili F, Koulibaly P, Rodriguez G, Benoit M, Girtler N, Robert P, et al. 99mTc-HMPAO and 99mTc-ECD brain uptake correlates of verbal memory in Alzheimer's disease. Q J Nucl Med Mol Imaging. 2007;51:357-63 pubmed
    ..We investigated the differences between the 2 compounds in research work by assessing correlation between performance on a verbal memory task and cerebral perfusion in 2 matched groups of AD patients...
  76. Nobili F, Frisoni G, Portet F, Verhey F, Rodriguez G, Caroli A, et al. Brain SPECT in subtypes of mild cognitive impairment. Findings from the DESCRIPA multicenter study. J Neurol. 2008;255:1344-53 pubmed publisher
    ..The aMCI group exhibited a pattern that is typical of early Alzheimer's disease, while the naMCI group showed a more anterior pattern of hypoperfusion. Instead, a homogeneous group effect was lacking in SUBJ...
  77. Del Carmen Plancha Mansanet M, Caballero Calabuig E, Félix Fontestad J, Reyes Ojeda M, Sopena Novales P, Abreu Sánchez P, et al. Stability of stabilized 99mTc-D,L-HMPAO stored in vials and syringes. J Nucl Med Technol. 2008;36:213-6 pubmed publisher
    ..Our objective was to determine the stability of stabilized (99m)Tc-hexamethylpropylene amine oxime ((99m)Tc-d,l-HMPAO) dispensed by vial and syringe, with the storage time and labeling activity varied...
  78. de Soras X, Brard P. [Algodystrophy versus postoperative infection: use of labelled white cell scans in differential diagnosis in the hand; a case report]. Chir Main. 2009;28:123-5 pubmed publisher
    ..However, the use of white blood cell scintigraphy should remain exceptional, because of its complexity and expense...
  79. Palmigiano A, Pastor J, Sola R, Ortega G. [Significance of complex analysis of electrical activity in temporal lobe epilepsy: electrocorticography]. Rev Neurol. 2012;55:207-16 pubmed
    ..Some patients, however, continue to suffer from attacks even after surgery. Therefore, new hypotheses must be formulated in order to account for the apparent shortcomings of correctly performed surgical procedures...
  80. Liberatore M, Poscente M, Prosperi D, Mancini B, Iurilli A, Donnetti M, et al. The effects of 99mTc-HMPAO-labelled leucocyte scan on human karyotype. Eur J Nucl Med Mol Imaging. 2003;30:1365-70 pubmed
    ..The high-dose radiation administered to lymphocytes was almost certainly sufficient to kill these cells...
  81. Oner N, Cermik T, Alpay M, Turan C, Aladağ N, Karasalihoglu S. 99mTc-HMPAO single photon emission computed tomography (SPECT) in both asphyxiated and epileptic children with or without status epilepticus. J Child Neurol. 2005;20:560-5 pubmed
    ..These children might be candidates for refractory convulsive disease, and interictal SPECT can be a reliable method for the detection of brain lesions in these patients...
  82. Fernandez P, Monet A, Matei C, De Clermont H, Guyot M, Jeandot R, et al. 99mTc-HMPAO labelled white blood cell scintigraphy in patients with osteoarticular infection: the value of late images for diagnostic accuracy and interobserver reproducibility. Eur J Clin Microbiol Infect Dis. 2008;27:1239-44 pubmed publisher
    ..5) at 4 h and 80% (kappa = 0.74) at 24 h, respectively. WBCS with 24-h images improves specificity and interobserver reproducibility in patients with suspected osteoarticular sepsis...
  83. Davis M, Ravenel J. Paraneoplastic limbic encephalitis due to thymic carcinoid. J Thorac Oncol. 2008;3:1484-6 pubmed publisher
    ..We present a case of limbic encephalitis associated with a thymic carcinoid tumor. To our knowledge the association of thymic carcinoid tumor with paraneoplastic limbic encephalitis has not previously been reported...
  84. Brockmann H, Zobel A, Joe A, Biermann K, Scheef L, Schuhmacher A, et al. The value of HMPAO SPECT in predicting treatment response to citalopram in patients with major depression. Psychiatry Res. 2009;173:107-12 pubmed publisher
    ..This effect is highly significant and, most notably, independent of the initial HRSD score...
  85. Mitsumoto T, Ohya N, Ichimiya A, Sakaguchi Y, Kiyota A, Abe K, et al. Diagnostic performance of Tc-99m HMPAO SPECT for early and late onset Alzheimer's disease: a clinical evaluation of linearization correction. Ann Nucl Med. 2009;23:487-95 pubmed publisher
    ..This study examined the influence of linearization correction (LC) on brain perfusion single-photon emission computed tomography (SPECT) for the diagnosis of Alzheimer's disease (AD)...
  86. Blend M, Rohany M, Jones Martinez N, De Leon O. Case study of Tc-99m HMPAO brain SPECT imaging in a patient with hepatic encephalopathy and carotid artery stenosis. Clin Nucl Med. 2010;35:317-20 pubmed publisher
    ..The possible causes and significance for these image findings are discussed...
  87. Apostolova I, Wunder A, Dirnagl U, Michel R, Stemmer N, Lukas M, et al. Brain perfusion SPECT in the mouse: normal pattern according to gender and age. Neuroimage. 2012;63:1807-17 pubmed publisher
    ..ECD is not suitable as tracer for brain SPECT in the mouse because of its fast clearance from tissue indicating an interspecies difference in esterase activity between mice and humans...
  88. Mizobuchi M, Matsuda K, Inoue Y, Sako K, Sumi Y, Chitoku S, et al. Dystonic posturing associated with putaminal hyperperfusion depicted on subtraction SPECT. Epilepsia. 2004;45:948-53 pubmed
    ..We evaluated the ictal hyperperfusional areas in patients with DP by using ictal-interictal subtraction single-photon emission computed tomography (SPECT)...
  89. Okuyaz C, Gucuyener K, Karabacak N, Aydin K, Serdaroglu A, Cingi E. Tc-99m-HMPAO SPECT in the diagnosis of brain death in children. Pediatr Int. 2004;46:711-4 pubmed
  90. Pagani M, Salmaso D, Rodriguez G, Nardo D, Nobili F. Principal component analysis in mild and moderate Alzheimer's disease--a novel approach to clinical diagnosis. Psychiatry Res. 2009;173:8-14 pubmed publisher
    ..These findings may allow neurophysiological inferences to be drawn regarding brain functional connectivity in AD that might not be possible with univariate analysis...
  91. Massollo M, Podesta M, Marini C, Morbelli S, Cassanelli C, Pinto V, et al. Contact with the bone marrow microenvironment readdresses the fate of transplanted hematopoietic stem cells. Exp Hematol. 2010;38:968-77 pubmed publisher
    ..However, the mechanisms underlying the benefit provided by this procedure remain unknown. This study aims to evaluate the effect of IB on HSCs trafficking and homing features in the living rat...
  92. Erba P, Conti U, Lazzeri E, Sollini M, Doria R, De Tommasi S, et al. Added value of 99mTc-HMPAO-labeled leukocyte SPECT/CT in the characterization and management of patients with infectious endocarditis. J Nucl Med. 2012;53:1235-43 pubmed publisher