p methoxy n methylphenethylamine

Summary

Summary: A potent mast cell degranulator. It is involved in histamine release.

Top Publications

  1. Liu S, Hiedayati N, Shudou M, Maeyama K. Activation of connective tissue-type and mucosal-type mast cells in compound 48/80-induced airway response. Eur J Pharmacol. 2006;530:128-35 pubmed
    ..Mast cell degranulation is responsible for the early phase of airway response, which subsequently triggers the late phase of airway response...
  2. Boros M, Ordögh B, Kaszaki J, Nagy S. The role of mast cell degranulation in ischaemia-reperfusion-induced mucosal injury in the small intestine. Ann Acad Med Singapore. 1999;28:79-84 pubmed
    ..Depletion of mast cells prior to ischaemia decreases the severity of mucosal damage, probably in consequence of the stimulation of mucosal histidine decarboxylase activity...
  3. Jernejc K, Legisa M. Activation of plasma membrane H+-ATPase by ammonium ions in Aspergillus niger. Appl Microbiol Biotechnol. 2001;57:368-73 pubmed
    ..niger is mediated via the phosphatidyl-inositol signalling pathway, involving Ca2+/calmoduline-dependent protein kinase but not protein kinase C...
  4. Esquisatto L, Costa S, Camargo E, Ribela M, Brain S, de Nucci G, et al. The plasma protein extravasation induced by adenosine and its analogues in the rat dorsal skin: evidence for the involvement of capsaicin sensitive primary afferent neurones and mast cells. Br J Pharmacol. 2001;134:108-15 pubmed
  5. Lim K. Inhibitory effect of glycoprotein isolated from Opuntia ficus-indica var. saboten MAKINO on activities of allergy-mediators in compound 48/80-stimulated mast cells. Cell Immunol. 2010;264:78-85 pubmed publisher
    ..Thus, we speculate that the OFI glycoprotein is an example of natural compound that blocks anti-allergic signal transduction pathways...
  6. Lee H, Ota Setlik A, Xu H, D Agati V, Jacobson M, Emala C. A3 adenosine receptor knockout mice are protected against ischemia- and myoglobinuria-induced renal failure. Am J Physiol Renal Physiol. 2003;284:F267-73 pubmed
    ..125 mg/kg IB-MECA) exacerbated renal I/R injury in mice. Mice lacking A(3) ARs or blocking A(3) ARs in wild-type mice resulted in significant renal protection from ischemic or myoglobinuric renal failure...
  7. Palomäki V, Laitinen J. The basic secretagogue compound 48/80 activates G proteins indirectly via stimulation of phospholipase D-lysophosphatidic acid receptor axis and 5-HT1A receptors in rat brain sections. Br J Pharmacol. 2006;147:596-606 pubmed
    ..This property may also contribute to the compound's ability to release histamine from mast cells...
  8. Jesse C, Savegnago L, Nogueira C. Role of nitric oxide/cyclic GMP/K(+) channel pathways in the antinociceptive effect caused by 2,3-bis(mesitylseleno)propenol. Life Sci. 2007;81:1694-702 pubmed
    ..Taken together, these results suggest that the antinociceptive effect of selenide on the formalin test involves the participation of nitric oxide/cyclic GMP/K(+) channel pathways in rats...
  9. Shi T, Kim H. Inhibition of immediate-type allergic reactions by the aqueous extract of Salvia plebeia. Immunopharmacol Immunotoxicol. 2002;24:303-14 pubmed
    ..These results indicate that SPAE may possess strong antiallergic activity and suggest that differences in bioavailability may cause differential activity following different administration routes...

More Information

Publications62

  1. Trinh H, Bae E, Lee J, Kim D. Inhibitory effects of curcuminoids on passive cutaneous anaphylaxis reaction and scratching behavior in mice. Arch Pharm Res. 2009;32:1783-7 pubmed publisher
    ..These findings suggest that curcuminoids, particularly curcumin, can improve the symptoms of allergic diseases, such as anaphylaxis and itching...
  2. Bytautiene E, Vedernikov Y, Saade G, Romero R, Garfield R. Endogenous mast cell degranulation modulates cervical contractility in the guinea pig. Am J Obstet Gynecol. 2002;186:438-45 pubmed
    ..The purpose of this study was to investigate the effect of endogenous mast cell degranulation on the contractility of isolated cervical strips from nonpregnant and pregnant guinea pigs...
  3. Segawa S, Takata Y, Kaneda H, Watari J. Effects of a hop water extract on the compound 48/80-stimulated vascular permeability in ICR mice and histamine release from OVA-sensitized BALB/c mice. Biosci Biotechnol Biochem. 2007;71:1577-81 pubmed
    ..These results indicate that HWE exerted an antiallergic effect by inhibiting the release of chemical mediators from mast cells and basophiles...
  4. Li G, Chai O, Song C. Inhibitory effects of epigallocatechin gallate on compound 48/80-induced mast cell activation and passive cutaneous anaphylaxis. Exp Mol Med. 2005;37:290-6 pubmed
  5. Piovezan A, D Orléans Juste P, Frighetto M, Souza G, Henriques M, Rae G. Endothelins contribute towards nociception induced by antigen in ovalbumin-sensitised mice. Br J Pharmacol. 2004;141:755-63 pubmed
    ..The apparently distinct roles played by ET(B) receptors in this phenomenon at local and other sites remain to be characterised...
  6. Furukawa Y, Furuno T, Teshima R, Nakanishi M. Calcium signals in rat basophilic leukemia (RBL-2H3) cells primed with the neuropeptide substance P. Biol Pharm Bull. 2001;24:1060-3 pubmed
    ..5 microM) for one week. The present results provide a foundation to study the neuroimmune cross-talk in a co-culture system...
  7. Zancan P, Rosas A, Marcondes M, Marinho Carvalho M, Sola Penna M. Clotrimazole inhibits and modulates heterologous association of the key glycolytic enzyme 6-phosphofructo-1-kinase. Biochem Pharmacol. 2007;73:1520-7 pubmed
    ..Altogether, our data support a hitherto unrecognized action of clotrimazole as a negative modulator of glycolytic flux through direct inhibition of the key enzyme PFK...
  8. Lee B, Bae E, Trinh H, Shin Y, Phuong T, Bae K, et al. Inhibitory effect of schizandrin on passive cutaneous anaphylaxis reaction and scratching behaviors in mice. Biol Pharm Bull. 2007;30:1153-6 pubmed
    ..Schizandrin reduced the protein expressions of TNF-alpha and IL-4 in IgE-induced RBL 2H3 cells. These findings suggest that schizandrin can improve IgE-induced anaphylaxis and scratching behaviors...
  9. Lee J, Lim K. Inhibitory effect of phytoglycoprotein (24kDa) on allergy-related factors in compound 48/80-induced mast cells in vivo and in vitro. Int Immunopharmacol. 2010;10:591-9 pubmed publisher
    ..Taken together, we speculate that the ZPDC glycoprotein might be one component found in natural products that has the ability to prevent dysfunction in the immune system caused by several different allergens...
  10. Kim S, Kwon Y, Park W, Jeon H, Shin T. Effect of leaves of Eriobotrya japonica on anaphylactic allergic reaction and production of tumor necrosis factor-alpha. Immunopharmacol Immunotoxicol. 2009;31:314-9 pubmed publisher
    ..These findings provide evidence that LEJL could be a candidate as an anti-allergic agent...
  11. Yillar D, Kucukhuseyin C. The effects of compound 48/80, morphine, and mast cell depletion on electroshock seizure in mice. J Basic Clin Physiol Pharmacol. 2008;19:1-14 pubmed
    ..The effects of compound 48/80 (C48/80), morphine, and mast cell depletion on maximal electroshock seizure (MES) were studied in Swiss albino mice...
  12. Mathew J, Srinivasan K, Dinakaran V, Joseph A. Mast cell stabilizing effects of Sphaeranthus indicus. J Ethnopharmacol. 2009;122:394-6 pubmed
    ..These results suggest that S. indicus has potent mast cell stabilizing effects thereby inhibiting mediator release from mast cells. ..
  13. Penissi A, Vera M, Mariani M, Rudolph M, Ceñal J, de Rosas J, et al. Novel anti-ulcer alpha,beta-unsaturated lactones inhibit compound 48/80-induced mast cell degranulation. Eur J Pharmacol. 2009;612:122-30 pubmed publisher
    ..Our findings may provide an insight into the design of novel pharmacological agents which may be used to regulate the mast cell response...
  14. Lidegran M, Domeij S, Forsgren S, Dahlqvist A. Mast cells in the laryngeal mucosa of the rat. Effect of compound 48/80 and dexamethasone: a quantitative and immunohistochemical study at the light- and electron-microscopic levels. Acta Anat (Basel). 1996;157:135-43 pubmed
    ..This study shows that MMCs in the epiglottic and subglottic regions may be of two subtypes, differing in number and size of the granules as well as in chemical content...
  15. Dib M, Zhao X, Wang X, Andersson R. Mast cells contribute to early pancreatitis-induced systemic endothelial barrier dysfunction. Pancreatology. 2002;2:396-401 pubmed
    ..The aim of the study was to evaluate the effect of mast cell stimulation on the early development of multiple organ dysfunction (MODS) in acute pancreatitis (AP)...
  16. Lakshmana M, Rafiq M, Sridhar B. Evaluation of E-721B, an indigenous herbal combination in experimental models of immediate hypersensitivity. Indian J Physiol Pharmacol. 2001;45:319-28 pubmed
    ..All the above results indicate the inhibitory effect of E-721B on immediate hypersensitive reactions such as asthma...
  17. Shin T, Kim D, Chae B, Lee E. Antiallergic action of Magnolia officinalis on immediate hypersensitivity reaction. Arch Pharm Res. 2001;24:249-55 pubmed
    ..01 to 1 mg/ml) had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-alpha production from RPMC. These results indicate that MOAE inhibits immediate hypersensitivity reaction in vivo and in vitro...
  18. Kim H, Kim Y, Moon H, Lee E, Moon S, An N. Inhibitory effect of anaphylactic reaction of Sosiho-Tang. Immunopharmacol Immunotoxicol. 1998;20:567-78 pubmed
    ..These results indicate that SS-Tang may contain compounds with actions that inhibit mast cell degranulation...
  19. Zhang Q, Andoh T, Konno M, Lee J, Hattori M, Kuraishi Y. Inhibitory effect of methanol extract of Ganoderma lucidum on acute itch-associated responses in mice. Biol Pharm Bull. 2010;33:909-11 pubmed
    ..These results raise the possibility that MEGL is effective against pruritus mediated by proteinases and 5-HT and that primary afferents expressing PAR(2) and 5-HT(2A) receptors are the sites of its action...
  20. Sawynok J, Reid A, Liu X. Involvement of mast cells, sensory afferents and sympathetic mechanisms in paw oedema induced by adenosine A(1) and A(2B/3) receptor agonists. Eur J Pharmacol. 2000;395:47-50 pubmed
    ..The nature of the involvement of the sympathetic nervous system in the action of N(6)-B-NECA is not entirely clear...
  21. Ahluwalia A, Giuliani S, Maggi C. Demonstration of a 'septide-sensitive' inflammatory response in rat skin. Br J Pharmacol. 1995;116:2170-4 pubmed
    ..These data support the existence of a distinct 'septide-sensitive' receptor/binding site and suggest that this site is involved in tachykinin-induced oedema formation in rat skin...
  22. Kim S, Choi C, Kim S, Eun J, Shin T. Anti-allergic effects of Artemisia iwayomogi on mast cell-mediated allergy model. Exp Biol Med (Maywood). 2005;230:82-8 pubmed
    ..Our findings provide evidence that AIE inhibits mast cell-derived immediate-type allergic reactions and involvement of intracellular Ca(2+), proinflammatory cytokines, p38 MAPK, and NF-kappaB in these effects...
  23. Kim E, Kim E, Moon P, Um J, Kim H, Lee H, et al. Lithospermi radix extract inhibits histamine release and production of inflammatory cytokine in mast cells. Biosci Biotechnol Biochem. 2007;71:2886-92 pubmed
    ..Furthermore, the in vivo and in vitro anti-allergic effect of LR suggests possible therapeutic applications of this agent for inflammatory allergic diseases...
  24. Jiang S, Nakano Y, Yatsuzuka R, Ono R, Kamei C. Inhibitory effects of Moutan cortex on immediate allergic reactions. Biol Pharm Bull. 2007;30:1707-10 pubmed
    ..The main active component of Moutan Cortex is considered to be contained in extract (B). In conclusion, Moutan Cortex may be useful for the relief of symptoms of atopic dermatitis and other allergy-related diseases...
  25. Martins M, Pasquale C, e Silva P, Pires A, Ruffie C, Rihoux J, et al. Interference of cetirizine with the late eosinophil accumulation induced by either PAF or compound 48/80. Br J Pharmacol. 1992;105:176-80 pubmed
    ..The mechanism is neither related to its recognized ability to antagonize histamine H,-receptors nor to a direct action upon circulating eosinophils...
  26. Marcondes S, Bau E, Antunes E, Dietrich C, Nader H, De Nucci G. Inhibition of heparin synthesis by methotrexate in rats in vivo. Biochem Pharmacol. 2002;64:169-75 pubmed
  27. Grosman N. Ether phospholipids affect mast cell histamine release with relative potency similar to that with leukocyte membrane Ca2+-ATPase activity. Inflamm Res. 2002;51 Suppl 1:S05-6 pubmed
  28. Ikarashi Y, Yuzurihara M, Sakakibara I, Takahashi A, Ishimaru H, Maruyama Y. Effects of an oriental herbal medicine, "Saiboku-to", and its constituent herbs on Compound 48/80-induced histamine release from peritoneal mast cells in rats. Phytomedicine. 2001;8:8-15 pubmed
    ..15% inhibition). From these results, it is suggested that the anti-histamine release effect of Saiboku-to, which contains 10 herbs, may be due mainly to the effect of Magnoliae Cortex and the synergism of the 3 other herbs...
  29. McGowen A, Hale L, Shelburne C, Abraham S, Staats H. The mast cell activator compound 48/80 is safe and effective when used as an adjuvant for intradermal immunization with Bacillus anthracis protective antigen. Vaccine. 2009;27:3544-52 pubmed publisher
    ..Our data demonstrate that C48/80 is a safe and effective adjuvant, when used by the intradermal route, to induce protective antibody and balanced Th1/Th2/Th17 responses...
  30. Yeung C, Law J, Sam S, Ingebrandt S, Lau H, Rudd J, et al. Modulatory action of potassium channel openers on field potential and histamine release from rat peritoneal mast cells. Can J Physiol Pharmacol. 2009;87:624-32 pubmed publisher
    ..It is possible that KCO hyperpolarizes the cell membrane, enhances Ca2+ influx, and thus increases histamine release. As such, selective blockers of K+ channels may be useful for the treatment of immunological disorders...
  31. Kaur R, O Shaughnessy C, Jarvie E, Winchester W, McLean P. Characterization of a calcitonin gene-related peptide release assay in rat isolated distal colon. Arch Pharm Res. 2009;32:1775-81 pubmed publisher
    ..We conclude that CGRP release in the rat distal colon occurs in response to mast cell degranulation, inflammatory mediators, low pH and capsaicin and describe a role for TRPV1 receptors in mediating the response...
  32. Yatsuzuka R, Nakano Y, Jiang S, Ueda Y, Kishi Y, Suzuki Y, et al. Effect of Usuhiratake (Pleurotus pulmonarius) on sneezing and nasal rubbing in BALB/c mice. Biol Pharm Bull. 2007;30:1557-60 pubmed
    ..These results demonstrated that Pleurotus pulmonarius may be effective in the relief of symptoms of allergic rhinitis through inhibition of histamine release...
  33. Kamei C, Akagi M, Mio M, Kitazumi K, Izushi K, Masaki S, et al. Antiallergic effect of epinastine (WAL 801 CL) on immediate hypersensitivity reactions: (I). Elucidation of the mechanism for histamine release inhibition. Immunopharmacol Immunotoxicol. 1992;14:191-205 pubmed
    ..The drug caused no visible changes in thermodynamic behavior of lipids, either in order parameter or in differential scanning calorimetry, indicating that the drug has no influence on membrane fluidity...
  34. Akhalaya M, Baizhumanov A, Graevskaya E. Effects of taurine, carnosine, and casomorphine on functional activity of rat peritoneal mast cells. Bull Exp Biol Med. 2006;141:328-30 pubmed
    ..Casomorphine inhibited histamine release induced by ionophore A23187, but potentiated the effect of compound 48/80. The mechanisms for these effects are discussed...
  35. Celuch S, Sloley B. Release of 5-hydroxytryptamine, dopamine and noradrenaline in the rat vas deferens in the presence of compound 48/80, veratridine or K+. Br J Pharmacol. 1989;96:77-82 pubmed
    ..It is suggested that 5-HT could be a neuromodulator or a neurotransmitter in this organ. Veratridine and K+ induce the release of dopamine in addition to NA...
  36. Kim H, Moon P, Chae H, Kim H, Chung J, Kim J, et al. The stem of sinomenium acutum inhibits mast cell-mediated anaphylactic reactions and tumor necrosis factor-alpha production from rat peritoneal mast cells. J Ethnopharmacol. 2000;70:135-41 pubmed
    ..These results indicate that SSAE inhibits mast cell-mediated anaphylactic reactions and TNF-alpha production from mast cells...
  37. Anderson C, Ponce A, Price R. Absence of OX-43 antigen expression in invasive capillary sprouts: identification of a capillary sprout-specific endothelial phenotype. Am J Physiol Heart Circ Physiol. 2004;286:H346-53 pubmed
    ..Endothelial cells of this phenotype are particularly abundant in capillary sprouts that invade avascular tissue during angiogenesis...
  38. Shin T, Park S, Yoo J, Kim I, Lee H, Kwon T, et al. Anti-allergic inflammatory activity of the fruit of Prunus persica: role of calcium and NF-kappaB. Food Chem Toxicol. 2010;48:2797-802 pubmed publisher
    ..Our findings provide evidence that FPP inhibits mast cell-derived allergic inflammation and involvement of calcium and NF-kappaB in these effects...
  39. Shin T, Kim S, Lee E, Eom D, Kim H. Action of Rubus coreanus extract on systemic and local anaphylaxis. Phytother Res. 2002;16:508-13 pubmed
    ..Moreover, RCAE (0.01-1 mg/mL) had a significant inhibitory effect on anti-DNP IgE-induced tumour necrosis factor-alpha production from RPMC. These results indicate that RCAE may possess antianaphylactic action...
  40. Costa R, Marotta D, Manjavachi M, Fernandes E, Lima Garcia J, Paszcuk A, et al. Evidence for the role of neurogenic inflammation components in trypsin-elicited scratching behaviour in mice. Br J Pharmacol. 2008;154:1094-103 pubmed publisher
    ..We investigated the mechanisms underlying the pruritogenic response induced by trypsin in mice, to assess the relevance of neurogenic inflammation components in this response...
  41. Oskeritzian C, Zhao W, Min H, Xia H, Pozez A, Kiev J, et al. Surface CD88 functionally distinguishes the MCTC from the MCT type of human lung mast cell. J Allergy Clin Immunol. 2005;115:1162-8 pubmed
    ..MC(T) and MC(TC) types of human mast cells (MCs) are distinguished from one another on the basis of the protease compositions of their secretory granules, but their functional and developmental relationships have been uncertain...
  42. Carlos D, de Souza Júnior D, de Paula L, Jamur M, Oliver C, Ramos S, et al. Mast cells modulate pulmonary acute inflammation and host defense in a murine model of tuberculosis. J Infect Dis. 2007;196:1361-8 pubmed
    ..Mast cells (MCs) participate in host resistance to several pathogens, but little is known about the role played by MCs in Mycobacterium tuberculosis infection...
  43. Trentin P, Fernandes M, D Orléans Juste P, Rae G. Endothelin-1 causes pruritus in mice. Exp Biol Med (Maywood). 2006;231:1146-51 pubmed
    ..The findings with IRL-1620 and BQ-788 suggest that local ET(B) receptors exert an antipruritic role, but, for reasons still unknown, the results obtained using systemic A-192621 injection are at variance with this view...
  44. Penna S, Medeiros M, Aimbire F, Faria Neto H, Sertié J, Lopes Martins R. Anti-inflammatory effect of the hydralcoholic extract of Zingiber officinale rhizomes on rat paw and skin edema. Phytomedicine. 2003;10:381-5 pubmed
    ..The antiedematogenic activity seems to be related, at least partially, to an antagonism of the serotonin receptor...
  45. Kim C, Lee W, No K, Park S, Lee M, Lim S, et al. Anti-allergic action of buckwheat (Fagopyrum esculentum Moench) grain extract. Int Immunopharmacol. 2003;3:129-36 pubmed
    ..Taken together, these results suggest that anti-allergic action of BGE may be due to the inhibition of histamine release and cytokine gene expression in the mast cells...
  46. Ohta Y, Kobayashi T, Imai Y, Inui K, Yoshino J, Nakazawa S. Effect of oral vitamin E administration on acute gastric mucosal lesion progression in rats treated with compound 48/80, a mast cell degranulator. Biol Pharm Bull. 2006;29:675-83 pubmed
  47. Davani S, Muret P, Royer B, Kantelip B, Frances C, Millart H, et al. Ischaemic preconditioning and mast cell histamine release: microdialysis of isolated rat hearts. Pharmacol Res. 2002;45:383-90 pubmed
  48. Milosevic D, Janosevic L, Janosevic S. Intradermal tests with vasomotor agents in perennial non-allergic rhinitis. Acta Otorhinolaryngol Belg. 2000;54:465-71 pubmed
  49. Reggiani R, Laoreti P. Evidence for the involvement of phospholipase C in the anaerobic signal transduction. Plant Cell Physiol. 2000;41:1392-6 pubmed
    ..Stimulation of the anaerobic signal transduction pathway with aluminium fluoride (G protein activator) was attenuated by PLC inhibitors. These findings are consistent with the participation of PLC in the anaerobic response...
  50. Qin H, Shi Y, Liu Z, Li Z, Wang H, Wang H, et al. Effect of chlorogenic acid on mast cell-dependent anaphylactic reaction. Int Immunopharmacol. 2010;10:1135-41 pubmed publisher
    ..Decreased calcium uptake and increased cAMP level might be involved in the inhibitory effect of CGA on mast cell activation. These results suggest a possible therapeutic application of CGA in allergic diseases...
  51. Santos Rosa C, Garcia Gimenez M, Saenz Rodriguez M, De la Puerta Vazquez R. Antihistaminic and antieicosanoid effects of oleanolic and ursolic acid fraction from Helichrysum picardii. Pharmazie. 2007;62:459-62 pubmed
    ..From these data, it can be suggested that the triterpene isomers oleanolic and ursolic acids present in the medicinal plant Helichrysum picardii contribute to the anti-inflammatory profile of this vegetal species...
  52. Datti F, Datti M, Antunes E, Teixeira N. Influence of chronic unpredictable stress on the allergic responses in rats. Physiol Behav. 2002;77:79-83 pubmed
    ..Our results indicate that chronic unpredictable stress exacerbates the vascular and cellular inflammatory responses...
  53. Lau A, Chow S, Ng Y. Immunologically induced histamine release from rat peritoneal mast cells is enhanced by low levels of substance P. Eur J Pharmacol. 2001;414:295-303 pubmed