diphenhydramine

Summary

Summary: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.

Top Publications

  1. Jangi S, Asumendi A, Arlucea J, Nieto N, Perez Yarza G, Morales M, et al. Apoptosis of human T-cell acute lymphoblastic leukemia cells by diphenhydramine, an H1 histamine receptor antagonist. Oncol Res. 2004;14:363-72 pubmed
    ..We have examined the effects of histamine, diphenhydramine, and cimetidine (H1 and H2 histamine receptor antagonists, respectively) on the in vitro proliferation of two ..
  2. Tu R, Grewall P, Leung J, Suryaprasad A, Sheykhzadeh P, Doan C, et al. Diphenhydramine as an adjunct to sedation for colonoscopy: a double-blind randomized, placebo-controlled study. Gastrointest Endosc. 2006;63:87-94 pubmed
    ..b>Diphenhydramine hydrochloride possesses central nervous system depressant effects that theoretically could provide a ..
  3. Adachi N, Liu K, Ninomiya K, Matsuoka E, Motoki A, Irisawa Y, et al. Reduction of the infarct size by simultaneous administration of L-histidine and diphenhydramine in ischaemic rat brains. Resuscitation. 2011;82:219-21 pubmed publisher
    While diphenhydramine is a histamine H(1) receptor antagonist, the agent has been shown to inhibit histamine-N-methyltransferase, a histamine inactivating enzyme in the brain...
  4. Bender B, Berning S, Dudden R, Milgrom H, Tran Z. Sedation and performance impairment of diphenhydramine and second-generation antihistamines: a meta-analysis. J Allergy Clin Immunol. 2003;111:770-6 pubmed
    ..Despite dramatically higher cost, second-generation antihistamines are replacing diphenhydramine because of the perception that they are not constrained by its sedating effects.
  5. Bower E, Moore J, Moss M, Selby K, Austin M, Meeves S. The effects of single-dose fexofenadine, diphenhydramine, and placebo on cognitive performance in flight personnel. Aviat Space Environ Med. 2003;74:145-52 pubmed
    ..Selected second-generation antihistamines do not have such side effects and have been proposed for use in aircrew...
  6. Hou R, Scaife J, Freeman C, Langley R, Szabadi E, Bradshaw C. Relationship between sedation and pupillary function: comparison of diazepam and diphenhydramine. Br J Clin Pharmacol. 2006;61:752-60 pubmed
    To examine the relationship between sedation and pupillary function by comparing the effects of diazepam and diphenhydramine on arousal and pupillary activity.
  7. Sharma A, Pibarot P, Pilote S, Dumesnil J, Arsenault M, Bélanger P, et al. Modulation of metoprolol pharmacokinetics and hemodynamics by diphenhydramine coadministration during exercise testing in healthy premenopausal women. J Pharmacol Exp Ther. 2005;313:1172-81 pubmed
    ..Furthermore, the over-the-counter antihistamine diphenhydramine inhibited the metabolism of the CYP2D6 substrate metoprolol in healthy, young men with pharmacokinetic and ..
  8. Vuurman E, Rikken G, Muntjewerff N, de Halleux F, Ramaekers J. Effects of desloratadine, diphenhydramine, and placebo on driving performance and psychomotor performance measurements. Eur J Clin Pharmacol. 2004;60:307-13 pubmed
    ..Desloratadine is a potent, selective, histamine H(1)-receptor antagonist that does not easily cross the blood-brain barrier. It is nonsedating at therapeutic doses and should not affect driving or psychomotor performance...
  9. Mansfield L, Mendoza C, Flores J, Meeves S. Effects of fexofenadine, diphenhydramine, and placebo on performance of the test of variables of attention (TOVA). Ann Allergy Asthma Immunol. 2003;90:554-9 pubmed
    To determine the effects of diphenhydramine 50 mg and fexofenadine 180 mg on cognitive performance using the Test of Variables of Attention (TOVA), and to ascertain whether the TOVA was sufficiently sensitive to differentiate between the ..

Scientific Experts

More Information

Publications62

  1. Scharman E, Erdman A, Wax P, Chyka P, Caravati E, Nelson L, et al. Diphenhydramine and dimenhydrinate poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol (Phila). 2006;44:205-23 pubmed
    In 2003, there were 28,092 human exposures to diphenhydramine reported to poison centers in the US. A related drug, dimenhydrinate, is a less frequent cause of poisonings...
  2. Thormann M, Amthauer H, Adolf D, Wollrab A, Ricke J, Speck O. Efficacy of diphenhydramine in the prevention of vertigo and nausea at 7 T MRI. Eur J Radiol. 2013;82:768-72 pubmed publisher
    In this study the potential of diphenhydramine in reducing respectively preventing vertigo and nausea induced by the ultra-high static magnetic field at 7 T was evaluated.
  3. Liao C, Chang C, Tseng C, Sheen M, Tsai S, Chang Y, et al. Efficacy of intramuscular nalbuphine versus diphenhydramine for the prevention of epidural morphine-induced pruritus after cesarean delivery. Chang Gung Med J. 2011;34:172-8 pubmed
    Pruritus is the most common side effect of epidural morphine analgesia. Diphenhydramine is a widely used agent for the treatment of urticarial pruritus...
  4. Eschler D, Klein P. An evidence-based review of the efficacy of topical antihistamines in the relief of pruritus. J Drugs Dermatol. 2010;9:992-7 pubmed
    ..To critically review the body of clinical trials refuting or supporting the efficacy of topical antihistamines in the relief of pruritus...
  5. Glass J, Sproule B, Herrmann N, Streiner D, Busto U. Acute pharmacological effects of temazepam, diphenhydramine, and valerian in healthy elderly subjects. J Clin Psychopharmacol. 2003;23:260-8 pubmed
    ..study was performed to assess the comparative pharmacodynamics of single doses of temazepam (15 and 30 mg), diphenhydramine (50 and 75 mg), and valerian (400 and 800 mg) in 14 healthy elderly volunteers (mean age, 71...
  6. Baas J, Mol N, Kenemans J, Prinssen E, Niklson I, Xia Chen C, et al. Validating a human model for anxiety using startle potentiated by cue and context: the effects of alprazolam, pregabalin, and diphenhydramine. Psychopharmacology (Berl). 2009;205:73-84 pubmed publisher
  7. Dong Y, Chen X, Chen Y, Chen X, Hu Z. Separation and determination of pseudoephedrine, dextromethorphan, diphenhydramine and chlorpheniramine in cold medicines by nonaqueous capillary electrophoresis. J Pharm Biomed Anal. 2005;39:285-9 pubmed
    ..e. pseudoephedrine (PE), dextromethorphan (DXM), diphenhydramine (DHM) and chlorpheniramine (CLP)...
  8. Sanders R, Maddirala S, Geiger T, Pounds S, Sandlund J, Ribeiro R, et al. Premedication with acetaminophen or diphenhydramine for transfusion with leucoreduced blood products in children. Br J Haematol. 2005;130:781-7 pubmed
    ..1-30% of transfusions; physicians often premedicate patients with acetaminophen or diphenhydramine to prevent these reactions. The effectiveness of this practice has not been demonstrated...
  9. Sharma A, Pibarot P, Pilote S, Dumesnil J, Arsenault M, Bélanger P, et al. Toward optimal treatment in women: the effect of sex on metoprolol-diphenhydramine interaction. J Clin Pharmacol. 2010;50:214-25 pubmed publisher
    ..influences the pharmacokinetics and hemodynamics of the CYP2D6 substrate metoprolol and its interaction with diphenhydramine (CYP2D6 inhibitor) in healthy young participants with high (extensive metabolizer [EM]) or low (poor ..
  10. Weigert G, Zawinka C, Resch H, Schmetterer L, Garhofer G. Intravenous administration of diphenhydramine reduces histamine-induced vasodilator effects in the retina and choroid. Invest Ophthalmol Vis Sci. 2006;47:1096-100 pubmed
    ..The receptor mediating this response has not yet been identified. The present study was undertaken to clarify whether H1 receptor blockade with diphenhydramine affects the hemodynamic response of histamine in the choroid and the retina.
  11. Hasala H, Moilanen E, Janka Junttila M, Giembycz M, Kankaanranta H. First-generation antihistamines diphenhydramine and chlorpheniramine reverse cytokine-afforded eosinophil survival by enhancing apoptosis. Allergy Asthma Proc. 2007;28:79-86 pubmed
    ..The aim of this study was to investigate the effects of two first-generation antihistamines diphenhydramine and chlorpheniramine on constitutive eosinophil apoptosis and on interleukin (IL)-5-afforded eosinophil ..
  12. Au Yeung S, Rurak D, Gruber N, Riggs K. A pharmacokinetic study of diphenhydramine transport across the blood-brain barrier in adult sheep: potential involvement of a carrier-mediated mechanism. Drug Metab Dispos. 2006;34:955-60 pubmed
    The purpose of this study was to examine the disposition of diphenhydramine (DPHM) across the ovine blood-brain barrier (BBB)...
  13. Tashiro M, Duan X, Kato M, Miyake M, Watanuki S, Ishikawa Y, et al. Brain histamine H1 receptor occupancy of orally administered antihistamines, bepotastine and diphenhydramine, measured by PET with 11C-doxepin. Br J Clin Pharmacol. 2008;65:811-21 pubmed publisher
    ..However, only a few clinical studies regarding its sedative property are available. In addition, histamine H(1) receptor occupancy (H(1)RO) of this new antihistamine has never been measured by positron emission tomography (PET)...
  14. Merenstein D, Diener West M, Halbower A, Krist A, Rubin H. The trial of infant response to diphenhydramine: the TIRED study--a randomized, controlled, patient-oriented trial. Arch Pediatr Adolesc Med. 2006;160:707-12 pubmed
    To determine if infants aged 6 to 15 months with frequent parent-reported nighttime awakenings require reduced parental aid during a week of diphenhydramine hydrochloride treatment and 2 and 4 weeks after its discontinuation.
  15. Raphael G, Angello J, Wu M, Druce H. Efficacy of diphenhydramine vs desloratadine and placebo in patients with moderate-to-severe seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2006;96:606-14 pubmed
    Previous studies have shown that diphenhydramine and desloratadine effectively relieve symptoms of seasonal allergic rhinitis (SAR).
  16. Cole J, Stellpflug S, Gross E, Smith S. Wide complex tachycardia in a pediatric diphenhydramine overdose treated with sodium bicarbonate. Pediatr Emerg Care. 2011;27:1175-7 pubmed publisher
    b>Diphenhydramine is an antihistamine commonly implicated in overdose. It has many pharmacologic effects, including sodium channel blockade...
  17. Friedman B, Hochberg M, Esses D, Bijur P, Corbo J, Paternoster J, et al. A clinical trial of trimethobenzamide/diphenhydramine versus sumatriptan for acute migraines. Headache. 2006;46:934-41 pubmed
    ..Open-label studies suggest that the combination of trimethobenzamide and diphenhydramine (TMB/DPH) may provide effective relief in a high proportion of migraineurs.
  18. Thomas A, Nallur D, Jones N, Deslandes P. Diphenhydramine abuse and detoxification: a brief review and case report. J Psychopharmacol. 2009;23:101-5 pubmed publisher
    Many medicines available over the counter from pharmacies are known to have abuse potential, including diphenhydramine (DPH), an antihistamine with antimuscarinic properties used for the treatment of insomnia...
  19. Yoder K, Shaffer M, La Tournous S, Paul I. Child assessment of dextromethorphan, diphenhydramine, and placebo for nocturnal cough due to upper respiratory infection. Clin Pediatr (Phila). 2006;45:633-40 pubmed
    This study sought to investigate the efficacy of dextromethorphan (DM), diphenhydramine (DPH), and placebo (PL) for symptoms attributed to upper respiratory infections as determined by children, and to evaluate the concordance of ..
  20. Verster J, Volkerts E, van Oosterwijck A, Aarab M, Bijtjes S, de Weert A, et al. Acute and subchronic effects of levocetirizine and diphenhydramine on memory functioning, psychomotor performance, and mood. J Allergy Clin Immunol. 2003;111:623-7 pubmed
    ..These effects might interfere with memory functioning and psychomotor performance. Levocetirizine was recently introduced as a new antihistamine said to be free from sedative effects...
  21. Sadiq M, Borgs A, Okura T, Shimomura K, Kato S, Deguchi Y, et al. Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodone in vitro and in vivo. J Pharm Sci. 2011;100:3912-23 pubmed publisher
    b>Diphenhydramine (DPHM) and oxycodone are weak bases that are able to form cations. Both drugs show active uptake at the blood-brain barrier (BBB)...
  22. Morin C, Koetter U, Bastien C, Ware J, Wooten V. Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. Sleep. 2005;28:1465-71 pubmed
    ..Although it is often self-treated with herbal and dietary supplements or with over-the-counter sleep aids, there is still little evidence on the efficacy and safety of those products...
  23. Grillon C, Baas J, Pine D, Lissek S, Lawley M, Ellis V, et al. The benzodiazepine alprazolam dissociates contextual fear from cued fear in humans as assessed by fear-potentiated startle. Biol Psychiatry. 2006;60:760-6 pubmed
    ..The present study tested the hypothesis that alprazolam would reduce the sustained startle potentiation to contextual threats but not the startle potentiation to a threat cue...
  24. Correa C, Sudo G, Sudo R. Hemodynamic effects of atracurium and cisatracurium and the use of diphenhydramine and cimetidine. Rev Bras Anestesiol. 2010;60:52-63 pubmed
    Since atracurium can cause hypotension in humans, the hemodynamic effects of atracurium and cisatracurium as well as the hemodynamic protection of diphenhydramine and cimetidine were investigated in rats.
  25. Wang H, Bolognese J, Calder N, Baxendale J, Kehler A, Cummings C, et al. Effect of morphine and pregabalin compared with diphenhydramine hydrochloride and placebo on hyperalgesia and allodynia induced by intradermal capsaicin in healthy male subjects. J Pain. 2008;9:1088-95 pubmed publisher
    ..Compared with active placebo diphenhydramine (50 mg oral dose), pregabalin and morphine significantly reduced the area of secondary hyperalgesia over 15 ..
  26. Hou R, Langley R, Szabadi E, Bradshaw C. Comparison of diphenhydramine and modafinil on arousal and autonomic functions in healthy volunteers. J Psychopharmacol. 2007;21:567-78 pubmed
    ..First generation antihistamines, such as diphenhydramine, are likely to cause sedation by blocking excitatory H1 histamine receptors in the cerebral cortex, and the ..
  27. Sharma A, Hexdall A, Chang E, Nelson L, Hoffman R. Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate. Am J Emerg Med. 2003;21:212-5 pubmed
    b>Diphenhydramine, a common ingredient in over-the-counter medications, is often taken in overdose. Toxicity is usually limited to anticholinergic symptoms...
  28. Zhang D, Tashiro M, Shibuya K, Okamura N, Funaki Y, Yoshikawa T, et al. Next-day residual sedative effect after nighttime administration of an over-the-counter antihistamine sleep aid, diphenhydramine, measured by positron emission tomography. J Clin Psychopharmacol. 2010;30:694-701 pubmed
    ..crossover study in which we evaluated the residual effect the next day after nighttime administration of diphenhydramine, a commonly used OTC sleep aid, in terms of brain H? receptor occupancy (H?RO) measured using ¹¹C-doxepin-..
  29. Shadkam M, Mozaffari Khosravi H, Mozayan M. A comparison of the effect of honey, dextromethorphan, and diphenhydramine on nightly cough and sleep quality in children and their parents. J Altern Complement Med. 2010;16:787-93 pubmed publisher
    ..reliable treatment to control URIs and their related cough; however, drugs such as dextromethorphan (DM) and diphenhydramine (DPH) are now mainly used in the world...
  30. Ramachandran K, Sirop P. Rare complications of diphenhydramine toxicity. Conn Med. 2008;72:79-82 pubmed
    ..We present the case of a 33-year-old female who attempted suicide by ingesting diphenhydramine pills and had a course complicated by two rarely observed adverse effects of antihistamines: rhabdomyolysis ..
  31. Banerji A, Long A, Camargo C. Diphenhydramine versus nonsedating antihistamines for acute allergic reactions: a literature review. Allergy Asthma Proc. 2007;28:418-26 pubmed
    ..b>Diphenhydramine impairs psychomotor performance and cognitive function...
  32. Apiliogullari S, Keles B, Apiliogullari B, Balasar M, Yilmaz H, Duman A. Comparison of diphenhydramine and lidocaine for prevention of pain after injection of propofol: a double-blind, placebo-controlled, randomized study. Eur J Anaesthesiol. 2007;24:235-8 pubmed
    Pain on injection is still a problem with propofol. The purpose of the study was to compare the effectiveness of diphenhydramine and lidocaine on pain caused by propofol at the site of injection.
  33. Basu R, Dodge H, Stoehr G, Ganguli M. Sedative-hypnotic use of diphenhydramine in a rural, older adult, community-based cohort: effects on cognition. Am J Geriatr Psychiatry. 2003;11:205-13 pubmed
    ..The authors sought to identify patterns and associations of prescription and over-the-counter sedative-hypnotic use in an older, rural, blue-collar, community-based cohort in southwestern Pennsylvania over 10 years...
  34. Yonemitsu K, Koreeda A, Kohmatsu H, Ohtsu Y, Mimasaka S, Tsunenari S. [Two cases of diphenhydramine related suicide]. Chudoku Kenkyu. 2007;20:137-40 pubmed
    Two suicidal cases associated with ingestion of diphenhydramine (DPH) were reported. Case 1 is a typical DPH overdose case of a young man with the blood DPH concentration of 12.2 microg/ mL...
  35. Kennedy L, Case L, Hurd D, Cruz J, Pomper G. A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine pretransfusion medication versus placebo for the prevention of transfusion reactions. Transfusion. 2008;48:2285-91 pubmed publisher
    Acetaminophen and diphenhydramine are commonly used as pretransfusion medications to prevent transfusion reactions...
  36. Avsar A, Avsar F, Sahin M, Topaloglu S, Vatansev H, Belviranli M. Diphenhydramine and hyaluronic acid derivatives reduce adnexal adhesions and prevent tubal obstructions in rats. Eur J Obstet Gynecol Reprod Biol. 2003;106:50-4 pubmed
    The purpose of this study is to investigate the effects of diphenhydramine-HCl and Na-hyaluronate derivatives on the development of postoperative peritoneal adhesion and tubal obstruction.
  37. Paul I, Yoder K, Crowell K, Shaffer M, McMillan H, Carlson L, et al. Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. Pediatrics. 2004;114:e85-90 pubmed
    To determine whether the commonly used over-the-counter medications dextromethorphan and diphenhydramine are superior to placebo for the treatment of nocturnal cough and sleep difficulty associated with upper respiratory infections and ..
  38. Thomas R, Quinn M, Schuler B, Grem J. Hypersensitivity and idiosyncratic reactions to oxaliplatin. Cancer. 2003;97:2301-7 pubmed
    ..Oxaliplatin is a third-generation platinum analog that is used to treat a variety of solid tumors, particularly colorectal carcinoma. Patients may develop hypersensitivity reactions, although this complication occurs infrequently...
  39. Verster J, de Weert A, Bijtjes S, Aarab M, van Oosterwijck A, Eijken E, et al. Driving ability after acute and sub-chronic administration of levocetirizine and diphenhydramine: a randomized, double-blind, placebo-controlled trial. Psychopharmacology (Berl). 2003;169:84-90 pubmed
    ..Sedation following antihistamine use poses a danger to ambulant patients involved in daily activities such as driving...
  40. Agostini J, Leo Summers L, Inouye S. Cognitive and other adverse effects of diphenhydramine use in hospitalized older patients. Arch Intern Med. 2001;161:2091-7 pubmed
    b>Diphenhydramine hydrochloride is a commonly prescribed medicine in hospitalized patients, but its adverse effects on older patients remain unclear.
  41. Hamelin B, Bouayad A, Methot J, Jobin J, Desgagnés P, Poirier P, et al. Significant interaction between the nonprescription antihistamine diphenhydramine and the CYP2D6 substrate metoprolol in healthy men with high or low CYP2D6 activity. Clin Pharmacol Ther. 2000;67:466-77 pubmed
    The prototype "classic" over-the-counter antihistamine diphenhydramine was shown to interact with the polymorphic P450 enzyme CYP2D6...
  42. Lessard E, Yessine M, Hamelin B, Gauvin C, Labbe L, O Hara G, et al. Diphenhydramine alters the disposition of venlafaxine through inhibition of CYP2D6 activity in humans. J Clin Psychopharmacol. 2001;21:175-84 pubmed
    ..In vitro and in vivo studies showed that diphenhydramine, a nonprescription antihistamine, can inhibit CYP2D6 activity...
  43. Gomez M, Olsina R, Martinez L, Silva M. Simultaneous determination of dextromethorphan, diphenhydramine and phenylephrine in expectorant and decongestant syrups by capillary electrophoresis. J Pharm Biomed Anal. 2002;30:791-9 pubmed
    ..0 was found to be optimal. Dextromethorphan hydrobhromide, diphenhydramine hydrochloride and phenylephrine hydrochloride were baseline-separated in less than 11 min, giving separation ..
  44. Avsar F, Sahin M, Aksoy F, Avsar A, Akoz M, Hengirmen S, et al. Effects of diphenhydramine HCl and methylprednisolone in the prevention of abdominal adhesions. Am J Surg. 2001;181:512-5 pubmed
    The purpose of this study was to determine the effects of diphenhydramine hydrochloride and methylprednisolone in peritoneal adhesions.
  45. Tyler B, Groshan K, Cusack B, Richelson E. In vivo studies with low doses of levocabastine and diphenhydramine, but not pyrilamine, antagonize neurotensin-mediated antinociception. Brain Res. 1998;787:78-84 pubmed
    ..experiments in the rat addressing the role of levocabastine, and two other specific histamine H1 antagonists, diphenhydramine and pyrilamine, at neurotensin (NT)-mediated hypothermia and antinociception (hotplate)...
  46. Luna B, Scavone J, Greenblatt D. Doxylamine and diphenhydramine pharmacokinetics in women on low-dose estrogen oral contraceptives. J Clin Pharmacol. 1989;29:257-60 pubmed
    ..Ten women taking oral contraceptives and ten controls received a single 50 mg oral dose of diphenhydramine hydrochloride...
  47. Greene S, Reed C, Schroeter A. Double-blind crossover study comparing doxepin with diphenhydramine for the treatment of chronic urticaria. J Am Acad Dermatol. 1985;12:669-75 pubmed
    ..urticaria were studied to compare responses to treatment with doxepin (10 mg three times a day) and with diphenhydramine (25 mg three times a day). All patients had an evaluation that failed to disclose a cause for their disease...
  48. Koseoglu V, Kurekci A, Sarici U, Atay A, Ozcan O, Sorici U. Comparison of the efficacy and side-effects of ondansetron and metoclopramide-diphenhydramine administered to control nausea and vomiting in children treated with antineoplastic chemotherapy: a prospective randomized study. Eur J Pediatr. 1998;157:806-10 pubmed
    ..Ondansetron and the combination metoclopramide-diphenhydramine have been widely used in children...
  49. Weiler J, Bloomfield J, Woodworth G, Grant A, Layton T, Brown T, et al. Effects of fexofenadine, diphenhydramine, and alcohol on driving performance. A randomized, placebo-controlled trial in the Iowa driving simulator. Ann Intern Med. 2000;132:354-63 pubmed
    ..Sedating antihistamines may impair driving performance as seriously as alcohol...
  50. Barbas C, Garcia A, Saavedra L, Castro M. Optimization and validation of a method for the determination of caffeine, 8-chlorotheophylline and diphenhydramine by isocratic high-performance liquid chromatography. Stress test for stability evaluation. J Chromatogr A. 2000;870:97-103 pubmed
    The optimization of a HPLC method for caffeine, 8-chlorotheophylline and diphenhydramine separation with UV detection at 229 nm is described...
  51. Paine T, Jackman S, Olmstead M. Cocaine-induced anxiety: alleviation by diazepam, but not buspirone, dimenhydrinate or diphenhydramine. Behav Pharmacol. 2002;13:511-23 pubmed
    ..5 or 1.0 mg/kg buspirone), an antihistamine (50 mg/kg dimenhydrinate or 27 mg/kg diphenhydramine) or a saline injection. All drugs were administered intraperitoneally...
  52. Kuo C, Huang R, Lou B. Inhibition of Na(+) current by diphenhydramine and other diphenyl compounds: molecular determinants of selective binding to the inactivated channels. Mol Pharmacol. 2000;57:135-43 pubmed
    b>Diphenhydramine is an H1 histamine receptor antagonist, yet it also has a clinically useful local anesthetic effect...
  53. Ramaekers J, O Hanlon J. Acrivastine, terfenadine and diphenhydramine effects on driving performance as a function of dose and time after dosing. Eur J Clin Pharmacol. 1994;47:261-6 pubmed
    ..24 mg); the combination of acrivastine (8 mg) with pseudoephedrine (60 mg); terfenadine (60, 120 and 180 mg); diphenhydramine-HCl (50 mg); and placebo. The subjects were 18 healthy female volunteers...