diethylpropion

Summary

Summary: A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)

Top Publications

  1. Cercato C, Roizenblatt V, Leança C, Segal A, Lopes Filho A, Mancini M, et al. A randomized double-blind placebo-controlled study of the long-term efficacy and safety of diethylpropion in the treatment of obese subjects. Int J Obes (Lond). 2009;33:857-65 pubmed publisher
    To evaluate the efficacy of diethylpropion on a long-term basis, with emphasis in cardiovascular and psychiatric safety aspects.
  2. Abramowicz M, Van Haecke P, Demedts M, Delcroix M. Primary pulmonary hypertension after amfepramone (diethylpropion) with BMPR2 mutation. Eur Respir J. 2003;22:560-2 pubmed
    ..in a 27-yr-old female who developed PAH after a short course of the appetite-suppressant drug amfepramone (diethylpropion)...
  3. Santamaria A, Arias H. Neurochemical and behavioral effects elicited by bupropion and diethylpropion in rats. Behav Brain Res. 2010;211:132-9 pubmed publisher
    This study is an attempt to demonstrate whether bupropion (BP) and diethylpropion (DEP) exert their pharmacological actions by similar neurochemical mechanisms in the dorsal striatum...
  4. Arias H, Santamaria A, Ali S. Pharmacological and neurotoxicological actions mediated by bupropion and diethylpropion. Int Rev Neurobiol. 2009;88:223-55 pubmed publisher
    The antiappetite agent diethylpropion (DEP), and the antidepressant and antismoking aid compound bupropion (BP), not only share the same structural motif but also present similar mechanisms of action in the CNS...
  5. Feng J, Pan Z, Cao H, Wang C. [Determination of fenfluramine, diethylpropion and mazindol in slimming foods by gas chromatography-mass spectrometry]. Se Pu. 2004;22:228-30 pubmed
    A gas chromatography-mass spectrometry (GC/MS) analytical method for three anorectics drugs, fenfluramine, diethylpropion and mazindol, illegally adulterated in slimming foods has been developed...
  6. Glazer G. Long-term pharmacotherapy of obesity 2000: a review of efficacy and safety. Arch Intern Med. 2001;161:1814-24 pubmed
    ..4% or 3.4 kg for those receiving orlistat, and -1.5% or -1.5 kg for those receiving diethylpropion hydrochloride...
  7. Di Sacco G. Amfepramone does not cause primary pulmonary hypertension. Eur Respir J. 2004;23:790; author reply 790-1 pubmed
  8. Mey B, Paulus H, Lamparter E, Blaschke G. Kinetics of racemization of (+)- and (-)-diethylpropion: studies in aqueous solution, with and without the addition of cyclodextrins, in organic solvents and in human plasma. Chirality. 1998;10:307-15 pubmed
    The configurational stability of (+)- and (-)-diethylpropion [(+)- and (-)-2-(diethyl)-1-phenyl-1-propanone or (+)- and (-)-DEP] was investigated systematically from chemical, pharmaceutical, and pharmacological aspects...
  9. Garcia Mijares M, Bernardes A, Silva M. Diethylpropion produces psychostimulant and reward effects. Pharmacol Biochem Behav. 2009;91:621-8 pubmed publisher
    b>Diethylpropion (DEP) is a stimulant drug widely used for weight control in Brazil and other American countries. However, its effects on behavior and addiction potential are not yet well known...

More Information

Publications42

  1. Hertle R, Maybodi M, Mellow S, Yang D. Clinical and oculographic response to Tenuate Dospan (diethylpropionate) in a patient with congenital nystagmus. Am J Ophthalmol. 2002;133:159-60 pubmed
    ..Corona, California)...
  2. Souza D, Boehl P, Comiran E, Mariotti K, Pechansky F, Duarte P, et al. Determination of amphetamine-type stimulants in oral fluid by solid-phase microextraction and gas chromatography-mass spectrometry. Anal Chim Acta. 2011;696:67-76 pubmed publisher
    ..simultaneous identification and quantification of amphetamine (AMP), methamphetamine (MET), fenproporex (FEN), diethylpropion (DIE) and methylphenidate (MPH) in oral fluid collected with Quantisal™ device has been developed and ..
  3. Svendsen O, Toubro S, Breum L, Bruun J, Astrup A. [Drug treatment of obesity]. Ugeskr Laeger. 2006;168:163-7 pubmed
    ..However, until data on morbidity and mortality are available from RCTs, there is no absolute indication for prescribing drugs for treatment of obesity...
  4. Jasinski D, Krishnan S. Abuse liability and safety of oral lisdexamfetamine dimesylate in individuals with a history of stimulant abuse. J Psychopharmacol. 2009;23:419-27 pubmed publisher
    ..oral doses of 50, 100 (equivalent to 40 mg d-amphetamine), and 150 mg LDX, 40 mg d-amphetamine and 200 mg diethylpropion in 36 individuals with a history of stimulant abuse...
  5. Galvan Arzate S, Santamaria A. Neurotoxicity of diethylpropion: neurochemical and behavioral findings in rats. Ann N Y Acad Sci. 2002;965:214-24 pubmed
    The effects of diethylpropion (DEP), an amphetamine derivative and a well-known anorectic agent, on different neurochemical and behavioral markers of toxicity in rats were evaluated...
  6. Mortelmans L, Biesemans L, Van Rossom P. Homeopathic products, not as innocent and safe as they seem? A case report. Eur J Emerg Med. 2004;11:242-3 pubmed
    ..This case among other reports in the literature proves that homeopathic products are not as safe and harmless as they seem. Medical professionals as well as the public should be aware of this...
  7. Kutscher C. Action of fenfluramine, phenylpropanolamine, phentermine and diethylpropion on acoustic startle in rats. Pharmacol Biochem Behav. 1987;27:749-52 pubmed
    ..Instead, fenfluramine and phenylpropanolamine decreased startle responsiveness and phentermine and diethylpropion produced no change. There was no relationship between drug action and body weight...
  8. Carney M. Diethylpropion and psychosis. Clin Neuropharmacol. 1988;11:183-8 pubmed
    Five female patients who developed psychosis while taking diethylpropion hydrochloride are described, four with paranoid psychosis and one with manic psychosis. In all but one patient, these drugs were medically prescribed...
  9. Pokrajac M, Miljkovic B, Misailović B. Mass spectrometric investigation of 2-aminopropiophenones and some of their metabolites. Rapid Commun Mass Spectrom. 1991;5:59-61 pubmed
  10. Lucchetta R, Riveros B, Pontarolo R, Radominski R, Otuki M, Fernandez Llimos F, et al. Systematic review and meta-analysis of the efficacy and safety of amfepramone and mazindol as a monotherapy for the treatment of obese or overweight patients. Clinics (Sao Paulo). 2017;72:317-324 pubmed publisher
    ..Robust safety data were not identified to suggest changes in their regulatory status...
  11. Silva Nunes M, da Silva Nunes R, Silva Kahl V, Moysés Reyes J, da Silva J. Use of buccal micronucleus assay to determine mutagenicity induced by amfepramone in humans and the protective effects of vitamin C. J Toxicol Environ Health A. 2013;76:1121-8 pubmed publisher
    ..In addition, data demonstrated that vitamin C effectively inhibited amfepramone-induced DNA damage. ..
  12. Murphy J, Donald J, Molla A, Crowder D. A comparison of mazindol (Teronac) with diethylpropion in the treatment of exogenous obesity. J Int Med Res. 1975;3:202-6 pubmed
    Fifty obese patients were entered into a 12-week parallel group study of mazindol with diethylpropion in a general practice group. Both drugs produced weight loss, but patients on mazindol lost 19...
  13. Gevaerd M, Sultowski E, Takahashi R. Combined effects of diethylpropion and alcohol on locomotor activity of mice: participation of the dopaminergic and opioid systems. Braz J Med Biol Res. 1999;32:1545-50 pubmed
    ..In order to better understand the interactive effects of ethanol (EtOH) and diethylpropion (DEP) we examined the locomotion-activating effects of these drugs given alone or in combination in mice...
  14. Popa M, Stefănescu A, Dumitriu L. Decrease of urinary levels of adrenergic metabolites including conjugated MHPG after a short term course of diethylpropion in obese children fed a mixed, low-calorie diet. Endocrinologie. 1987;25:179-86 pubmed
    A short term course (8-11 days) of diethylpropion 50 mg a day was administered to 12 obese children of both sexes fed a mixed low calorie diet containing about 1000 calories/day...
  15. Crols R, Dierckx R, Saerens J, De Deyn P. Transient ischemic attacks associated with amfepramone therapy: a case report. Funct Neurol. 1993;8:351-4 pubmed
    ..The next day, the neurological examination was completely normal. Two weeks later, EEG and SPECT had completely normalized. Transient ischemic attacks due to vasospasm were considered to be the most probable clinical diagnosis...
  16. Alim T, Rosse R, Vocci F, Lindquist T, Deutsch S. Diethylpropion pharmacotherapeutic adjuvant therapy for inpatient treatment of cocaine dependence: a test of the cocaine-agonist hypothesis. Clin Neuropharmacol. 1995;18:183-95 pubmed
    ..patients completed a 2-week double-blind, double-dummy, parallel-group comparison of four dosage levels of diethylpropion and placebo...
  17. Dixon J. Weight loss medications--where do they fit in?. Aust Fam Physician. 2006;35:576-9 pubmed
    ..Obesity is a chronic disease requiring a similar long term approach to management as that of other chronic conditions...
  18. Zubaran C, Lazzaretti R. The use of appetite suppressants among health sciences undergraduate students in Southern Brazil. Einstein (Sao Paulo). 2013;11:47-52 pubmed
    ..To investigate the prevalence of appetite suppressant use among health sciences students in Southern Brazil...
  19. Reimer A, Martin Iverson M, Urichuk L, Coutts R, Byrne A. Conditioned place preferences, conditioned locomotion, and behavioral sensitization occur in rats treated with diethylpropion. Pharmacol Biochem Behav. 1995;51:89-96 pubmed
    b>Diethylpropion is a centrally acting appetite-suppressing drug thought to act primarily through catecholamine pathways in the brain...
  20. Gomez M, Alvarez A, Cid E. [Diethylpropion in magisterial formulations. Influence of cellulosis derivatives on in vitro stability and availability]. Rev Med Chil. 1993;121:1013-6 pubmed
    The aim of this work was to assess the degree of interaction between diethylpropion and some cellulosic derivatives widely used in anorexigenic prescriptions...
  21. Thomas S, Butt A, Corris P, Egan J, Higenbottam T, Madden B, et al. Appetite suppressants and primary pulmonary hypertension in the United Kingdom. Br Heart J. 1995;74:660-3 pubmed
    ..This study was performed to measure prior exposure to appetite suppressants in patients with primary pulmonary hypertension...
  22. Ollo C, Alim T, Rosse R, Lindquist T, Green T, Gillis T, et al. Lack of neurotoxic effect of diethylpropion in crack-cocaine abusers. Clin Neuropharmacol. 1996;19:52-8 pubmed
    ..We evaluated the effect of the stimulant diethylpropion on cognitive performance in a double-blind, placebo-controlled trial...
  23. Rosse R, Johri S, Deutsch S. Pupillary changes associated with the development of stimulant-induced mania: a case report. Clin Neuropharmacol. 1997;20:270-5 pubmed
    ..man who was a subject in a study evaluating the anticraving efficacy of the stimulant medication diethylpropion (DEP) became manic during his second week on the study drug...
  24. Mey B, Paulus H, Lamparter E, Blaschke G. Enantioseparation of amfepramone (rac-diethylpropion): preparative separation of the enantiomers and enantioselective analysis. Chirality. 1999;11:772-80 pubmed
    The enantiomers of the anorectic drug amfepramone [rac-diethylpropion, rac-2-(diethylamino)-1-phenyl-1-propanone; rac-DEP] were separated in the preparative scale by crystallization...
  25. Mello E, Maior R, Carey R, Huston J, Tomaz C, Müller C. Serotonin1A-receptor antagonism blocks psychostimulant properties of diethylpropion in marmosets (Callithrix penicillata). Eur J Pharmacol. 2005;511:43-52 pubmed
    b>Diethylpropion (1-phenyl-2-diethylamine-1-propanone hydrochloride) is a stimulant drug with reinforcing properties that is used to treat obesity in humans...
  26. Yu H, Rothman R, Dersch C, Partilla J, Rice K. Uptake and release effects of diethylpropion and its metabolites with biogenic amine transporters. Bioorg Med Chem. 2000;8:2689-92 pubmed
    Three metabolites of diethylpropion (1), (+/-)-2-ethylamino-1-phenyl-propan-1-one (2), (1R,2S)-(-)-N,N-diethylnorephedrine (3a) and (1S,2R)-(-)-N,N-diethylnorephedrine (3b) were synthesized...
  27. Little J, Romans S. Psychosis following readministration of diethyl proprion: a possible role for kindling?. Int Clin Psychopharmacol. 1993;8:67-70 pubmed
    ..The latter, however, provides a parsimonious explanation, a therapeutic rationale, and brings together seemingly disparate laboratory and clinical phenomena...
  28. Planeta C, Delucia R. Involvement of dopamine receptors in diethylpropion-induced conditioning place preference. Braz J Med Biol Res. 1998;31:561-4 pubmed
    b>Diethylpropion (DEP) is an amphetamine-like agent used as an anorectic drug. Abuse of DEP has been reported and some restrictions of its use have been recently imposed...
  29. Bispo Da Silva L, Cordellini S. Effects of diethylpropion treatment and withdrawal on aorta reactivity, endothelial factors and rat behavior. Toxicol Appl Pharmacol. 2003;190:170-6 pubmed
    b>Diethylpropion (DEP) is an amphetamine-like compound used as a coadjutant in the treatment of obesity and which presents toxicological importance as a drug of abuse...
  30. Lucchetta R, Riveros B, Pontarolo R, Radominski R, Otuki M, Fernandez Llimos F, et al. Diethylpropion and mazindol: An end to the discussion?. Rev Assoc Med Bras (1992). 2017;63:203-206 pubmed publisher
    ..Anvisa - Agência Nacional de Vigilância Sanitária) and medical societies over the maintenance record of diethylpropion, mazindol and fenproporex...
  31. Retuert P, Yazdani Pedram M. Studies on the compatibility of diethylpropion hydrochloride with carboxymethylcellulose and other dietary fibres. Farmaco. 1992;47:649-60 pubmed
    The combination of diethylpropion hydrochloride with carboxymethylcellulose induces decomposition of the drug...
  32. de Lima M, Beria J, Tomasi E, Mari J. Use of amphetamine-like appetite suppressants: a cross-sectional survey in Southern Brazil. Subst Use Misuse. 1998;33:1711-9 pubmed
    ..Forty-one different drugs had been prescribed. Mean length of use was 8.7 months. These findings are discussed in terms of the overreliance on anorectics as aids to dieting, the dangers of polypharmacy, and the risks of long-term use...
  33. Dangor C, Beckett A, Veltman A. Bioavailability of amfepramone hydrochloride sustained release pellets formulation in healthy subjects. Arzneimittelforschung. 1987;37:736-9 pubmed
    The relative bioavailability and pharmacokinetic profile of two amfepramone (diethylpropion) hydrochloride oral preparations were evaluated in 12 normal volunteers using a newly developed gas-liquid chromatographic procedure to monitor ..