diethylamines

Summary

Summary: Diethylamine with the formula CH3CH2NHCH2CH3 and its derivatives.

Top Publications

  1. Scheurer A, Ako A, Saalfrank R, Heinemann F, Hampel F, Petukhov K, et al. Synthesis, magnetic properties, and STM spectroscopy of cobalt(II) Cubanes [Co(II) (4)(Cl)(4)(HL)(4)]. Chemistry. 2010;16:4784-92 pubmed publisher
    ..In CITS measurements the rather large contrast found at the expected locations of the metal centers of the molecules indicated the presence of a strongly localized LUMO...
  2. Abi Gerges N, Szabo G, Otero A, Fischmeister R, Méry P. NO donors potentiate the beta-adrenergic stimulation of I(Ca,L) and the muscarinic activation of I(K,ACh) in rat cardiac myocytes. J Physiol. 2002;540:411-24 pubmed
    ..Although this action of NO seemed to occur at the level of G proteins, it appeared to require a component distinct from receptors, G proteins or their effectors...
  3. Biswas A, Adhvaryu A, Gordon S, Erhan S, Willett J. Synthesis of diethylamine-functionalized soybean oil. J Agric Food Chem. 2005;53:9485-90 pubmed
    ..Diethylamine and ZnCl2 were found to be the best. NMR, IR, and nitrogen analysis were used to characterize the products...
  4. Manzanas L, Jesús del Nozal M, Marcos M, Cordero Y, Bernal J, Goldschmidt P, et al. Oral flavonoids, chromocarb diethylamine salt and cyaninosides chloride, to eliminate lipoperoxidation postvitrectomy. Exp Eye Res. 2002;74:23-8 pubmed
    ..05). Vitrectomy induced increased malondialdehyde levels in the retina. Oral flavonoids are an effective protective therapy for surgically induced lipoperoxidation, especially in the retina...
  5. Iwasaki Y, Ichikawa Y, Igarasi O, Aoyagi J, Konno S, Ikeda K, et al. T-588 protects motor neuron death against glutamate-induced neurotoxicity. Neurochem Res. 2003;28:1829-32 pubmed
    ..Our data may provide a rationale for designing a therapeutic strategy for protection against pathologically induced motor neuron damage or cell death such as amyotrophic lateral sclerosis and motor neuropathy...
  6. Kirihara M, Niimi K, Okumura M, Momose T. Fluorinative Beckmann fragmentation: fluorinative alpha-cleavage of cyclic ketoximes by diethylaminosulfur trifluoride. Chem Pharm Bull (Tokyo). 2000;48:220-2 pubmed
    ..However, the introduction of a sulfur functionality, which can stabilize a carbocation and can be easily removed from the reaction products, into the ketoxime was effective for producing the fluorinative fragmentation...
  7. Stulak J, Lerman A, Caccitolo J, Wilson S, Romero J, Schaff H, et al. Impaired renal vascular endothelial function in vitro in experimental hypercholesterolemia. Atherosclerosis. 2001;154:195-201 pubmed
    ..These vascular alterations in HC could play a role in the pathogenesis of renal disease or hypertension, supporting a role for HC as a risk factor for renovascular disease...
  8. Chunfang Z, Yin X, Longjiang Y, Shuo L, Zeqiang W. TLC and HPLC methods to follow the synthesis of vinorelbine. J Chromatogr Sci. 2010;48:685-9 pubmed
    ..The calibration curve for VB shows good linearity in the two mass concentration ranges of 0.0100-0.0500 mg/mL (r = 0.9956) and 0.00600-0.0100 mg/mL (r = 0.9978), respectively. The limit of detection of HPLC for VB is 0.200 microg/mL...
  9. Karim M, Gu Z, Sawada A, Taniguchi T, Kawase K, Yamamoto T, et al. Neuroprotective effects of R(-)-1-(benzo[b]thiophen-5-yl)-2- [2-(N,N-diethylamino)ethoxy]ethanol hydrochloride (T-588) against retinal ganglion cell death induced by elevated intraocular pressure in rat. Jpn J Ophthalmol. 2002;46:621-6 pubmed
    ..We investigated whether T-588 can attenuate retinal ganglion cell (RGC) death induced by elevated intraocular pressure (IOP)...

More Information

Publications62

  1. Klink M, Jastrzembska K, Bednarska K, Banasik M, Sulowska Z. Effect of nitric oxide donors on NADPH oxidase signaling pathway in human neutrophils in vitro. Immunobiology. 2009;214:692-702 pubmed publisher
    ..We show that whereas NO donors have no effect on MAPKs activity, they do decrease PMA- and/or fMLP-induced phosphorylation of p47(phox) and PKC as well as PMA- and fMLP-induced ROS production...
  2. MOSS T, Barber D, Kyle A, Dixon D. Catalytic asymmetric alkylation reactions for the construction of protected ethylene-amino and propylene-amino motifs attached to quaternary stereocentres. Chemistry. 2013;19:3071-81 pubmed publisher
    ..Finally, the utility of the products have been demonstrated in the synthesis of useful heterocycles and compounds bearing structural components of natural products...
  3. Toney T, Katzenellenbogen B. An evaluation of the interactions of antiestrogens with pituitary and striatal dopamine receptors. J Recept Res. 1987;7:695-712 pubmed
    ..The relatively low affinity of AE's for the dopamine receptor and the high degree of interaction of AE's with other proteins suggest that only limited occupancy of D-2 receptors by AE's is likely in vivo...
  4. van de Rijke F, Heetebrij R, Talman E, Tanke H, Raap A. Fluorescence properties, thermal duplex stability, and kinetics of formation of cyanin platinum DNAs. Anal Biochem. 2003;321:71-8 pubmed
    ..The data provided are important for the design of optimal platinum DNA labeling and hybridization conditions for fluorescence hybridization applications...
  5. Yao C, Qi L, Yang G, Wang F. Preparation of sub-micron skeletal monoliths with high capacity for liquid chromatography. J Sep Sci. 2010;33:475-83 pubmed publisher
    ..0 cm/h. Those unique properties made the novel monolithic column a promising alternative to commercially available monolithic supports in LC applications...
  6. Micieli D, Giuffrida M, Pignatello R, Castelli F, Sarpietro M. Interaction of naproxen amphiphilic derivatives with biomembrane models evaluated by differential scanning calorimetry and Langmuir-Blodgett studies. J Colloid Interface Sci. 2011;360:359-69 pubmed publisher
    ..Experimental data showed that NAP conjugation with LAA residues was able to enhance the drug interaction with such biomembrane models...
  7. Nistor I, Lebrun P, Ceccato A, Lecomte F, Slama I, Oprean R, et al. Implementation of a design space approach for enantiomeric separations in polar organic solvent chromatography. J Pharm Biomed Anal. 2013;74:273-83 pubmed publisher
    ..Finally, the advantage of the DoE-DS approach resides in granting the possibility to concurrently assess robustness and identify the optimal conditions which are compound dependent...
  8. McElroy S, Gurney A, Drummond R. Pharmacological profile of store-operated Ca(2+) entry in intrapulmonary artery smooth muscle cells. Eur J Pharmacol. 2008;584:10-20 pubmed publisher
  9. Wang S, Paton J, Kasparov S. Differential sensitivity of excitatory and inhibitory synaptic transmission to modulation by nitric oxide in rat nucleus tractus solitarii. Exp Physiol. 2007;92:371-82 pubmed
    ..This differential sensitivity of excitatory and inhibitory connections to NO may be important for determining the specificity of the effects of this freely diffusible gaseous messenger...
  10. Dossou K, Chiap P, Chankvetadze B, Servais A, Fillet M, Crommen J. Enantioresolution of basic pharmaceuticals using cellulose tris(4-chloro-3-methylphenylcarbamate) as chiral stationary phase and polar organic mobile phases. J Chromatogr A. 2009;1216:7450-5 pubmed publisher
    ..Therefore, the studied compounds could be subdivided in three groups in respect to the acidic additive used. All analytes could be enantioseparated in relatively short analysis times (10-20 min) using these LC conditions...
  11. Parija T, Das B. Involvement of YY1 and its correlation with c-myc in NDEA induced hepatocarcinogenesis, its prevention by d-limonene. Mol Biol Rep. 2003;30:41-6 pubmed
  12. Poirot E, Chang A, Horton D, Kovac P. Synthetic explorations towards 3-deoxy-3-fluoro derivatives of D-perosamine. Carbohydr Res. 2001;334:195-205 pubmed
    ..Compounds 18 and 19 were converted, conventionally, into the 3-fluoro analogs of the terminal determinants of the O-PS of Vibrio cholerae O:1, serotype Inaba and Ogawa, respectively...
  13. Chakraborty S, Sahu S, Pramanik P, Roy S. In vitro antimicrobial activity of nanoconjugated vancomycin against drug resistant Staphylococcus aureus. Int J Pharm. 2012;436:659-76 pubmed publisher
  14. Lawrence A. Nitric oxide as a modulator of medullary pathways. Clin Exp Pharmacol Physiol. 1997;24:760-3 pubmed
    ..Furthermore, neurons that contain the enzyme NOS and that are, therefore, capable of using NO are localized in medullary nuclei concerned with both parasympathetic and sympathetic cardiovascular control pathways...
  15. Ongkudon C, Danquah M. Process optimisation for anion exchange monolithic chromatography of 4.2kbp plasmid vaccine (pcDNA3F). J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878:2719-25 pubmed publisher
    ..7M NaCl (pH 6) of binding buffer followed by increasing the NaCl concentration to 1.0M at 3%B/min...
  16. Yamaguchi H, Tamura R, Kuriwaki J, Eifuku S, Ono T. Effects of T-588, a cognitive enhancer compound, on synaptic plasticity in the dentate gyrus of freely moving rats. J Pharmacol Exp Ther. 2001;298:354-61 pubmed
    ..The effect of T-588 on long-term synaptic plasticity may contribute to the alleviation of learning and memory dysfunction seen in animal models...
  17. Ahmadi A, Khalili M, Seyedhoseyni S, Roudsari E, Nahri Niknafs B. Synthesis, antidiabetic and hypolipidemic activities of new diethylamine and triethoxysilyl derivatives of tolbutamide on rats. Med Chem. 2012;8:964-9 pubmed
  18. Huo T, Du X, Zhang S, Liu X, Li X. Gd-EDDA/HYNIC-RGD as an MR molecular probe imaging integrin alphanubeta3 receptor-expressed tumor-MR molecular imaging of angiogenesis. Eur J Radiol. 2010;73:420-7 pubmed publisher
    ..The aim of this study is to develop a novel MR probe containing arginine-glycine-aspartic acid (RGD) motif for imaging integrin alphanubeta3 receptor-expressed tumor...
  19. Hausladen A, Gow A, Stamler J. Nitrosative stress: metabolic pathway involving the flavohemoglobin. Proc Natl Acad Sci U S A. 1998;95:14100-5 pubmed
    ..Our results also emphasize that the reactions of SNO and NO with hemoglobins are evolutionary conserved, but have been adapted for cell-specific function...
  20. Khan B, Harrison D, Olbrych M, Alexander R, Medford R. Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells. Proc Natl Acad Sci U S A. 1996;93:9114-9 pubmed
    ..Through this mechanism, NO may function as an immunomodulator of the vessel wall and thus mediate inflammatory events involved in the pathogenesis of atherosclerosis...
  21. Obach R, Walker G, Brodney M. Biosynthesis of Fluorinated Analogs of Drugs Using Human Cytochrome P450 Enzymes Followed by Deoxyfluorination and Quantitative Nuclear Magnetic Resonance Spectroscopy to Improve Metabolic Stability. Drug Metab Dispos. 2016;44:634-46 pubmed publisher
    ..In summary, this method offers an approach whereby fluorine can be substituted in metabolically labile sites, and the products can be tested to determine whether an enhancement in metabolic stability was obtained. ..
  22. Nolan R, Teller J. Diethylamine extraction of proteins and peptides isolated with a mono-phasic solution of phenol and guanidine isothiocyanate. J Biochem Biophys Methods. 2006;68:127-31 pubmed
    ..Diethylamine provides efficient extraction of proteins and compatibility with a variety of common downstream analytical applications...
  23. Albayrak C, Kaştaş G, Odabaşoğlu M, Frank R. Probing the compound (E)-5-(diethylamino)-2-[(4-methylphenylimino)methyl]phenol mainly from the point of tautomerism in solvent media and the solid state by experimental and computational methods. Spectrochim Acta A Mol Biomol Spectrosc. 2011;81:72-8 pubmed publisher
    ..The computational investigation of non-linear optical properties indicates that the title compound has a good second order nonlinear optical property. The thermodynamic properties were obtained in the range of 100-500 K...
  24. Anxionnat B, Robert B, George P, Ricci G, Perrin M, Gomez Pardo D, et al. Ring expansion of cyclic ?-amino alcohols induced by diethylaminosulfur trifluoride: synthesis of cyclic amines with a tertiary fluorine at C3. J Org Chem. 2012;77:6087-99 pubmed publisher
    ..The scope and limitations of the ring expansion of cyclic 2-hydroxymethyl amines induced by diethylaminosulfur trifluoride (DAST) to produce cyclic ?-fluoro amines was studied as well as the enantioselectivity of the process...
  25. Parameshwara P, Karthikeyan J, Shetty A, Shetty P. 4-(N,N-diethylamino) benzaldehyde thiosemicarbazone in the spectrophotometric determination of palladium. Ann Chim. 2007;97:1097-106 pubmed
    ..The interference of various cations and anions in the method were studied. The proposed method was successfully used for the determination of Pd(II) in alloys, catalysts, complexes and model mixtures with a fair degree of accuracy...
  26. Okawa T, Asano K, Takahashi H, Sato A, Vedernikov Y, Saade G, et al. Nitric oxide donor-induced inhibition of pregnant rat uterine spontaneous contractile activity and release of nitric oxide from uterus measured by microdialysis. J Endocrinol Invest. 2005;28:998-1002 pubmed
  27. Zamponi G, French R. Open-channel block by internally applied amines inhibits activation gate closure in batrachotoxin-activated sodium channels. Biophys J. 1994;67:1040-51 pubmed
    ..Such a mechanism might underlie the previously reported immobilization of gating charge associated with local anesthetic block of unmodified sodium channels...
  28. Djordjevic L, Primorac M, Stupar M. In vitro release of diclofenac diethylamine from caprylocaproyl macrogolglycerides based microemulsions. Int J Pharm. 2005;296:73-9 pubmed
    ..Moreover, the obtained flux values for balanced microemulsions (29.38-63.70 microgcm(-2)h(-1)) suggested that bicontinuous microstructure hampers the release of the amphiphilic drug...
  29. van Och F, Vandebriel R, Prinsen M, De Jong W, Slob W, van Loveren H. Comparison of dose-responses of contact allergens using the guinea pig maximization test and the local lymph node assay. Toxicology. 2001;167:207-15 pubmed
    ..The nature of the data provided in the LLNA makes it likely that benchmarks as defined with this test are more reliable than that defined in the GPMT. However, further validation with human data is necessary...
  30. Wang M, Obrenovitch T, Urenjak J. Effects of the nitric oxide donor, DEA/NO on cortical spreading depression. Neuropharmacology. 2003;44:949-57 pubmed
    ..In this case, the molecular targets for NO may be located either on brain cells to suppress mechanisms directly involved in CSD genesis, or on local blood vessels to couple flow to the increased energy demand associated with CSD...
  31. Fulep E, Vedernikov Y, Saade G, Garfield R. Responses of isolated perfused uterine vascular beds of nonpregnant and pregnant rats to endogenous and exogenous nitric oxide. Gen Pharmacol. 2000;35:297-301 pubmed
  32. Vucinić Milanković N, Savic S, Vuleta G, Vucinić S. The physicochemical characterization and in vitro/in vivo evaluation of natural surfactants-based emulsions as vehicles for diclofenac diethylamine. Drug Dev Ind Pharm. 2007;33:221-34 pubmed
    ..In vivo study pointed to emulsion's favorable potential for skin hydration and barrier improvement, particularly in cetearyl glycoside-based vehicle...
  33. Kleinsasser N, Harréus U, Wallner B, Kastenbauer E. [Mutagen sensitivity of patients with laryngeal and oropharyngeal carcinoma]. Laryngorhinootologie. 1999;78:679-84 pubmed
  34. Maekawa M, Murayama T, Nomura Y. Involvement of noradrenaline transporters in S-nitrosocysteine-stimulated noradrenaline release from rat brain slices: existence of functional Na(+)-independent transporter activity. Neurochem Int. 2001;38:323-31 pubmed
    ..These findings suggest the existence of a functional Na(+)-independent NA transport system and that SNC stimulates NA release at least partially via this system in brain slices...
  35. Hirano J, Hamase K, Miyata H, Zaitsu K. 6,7-Difluoro-1,4-dihydro-1-methyl-4-oxo-3-quinolinecarboxylic acid, a newly designed fluorescence enhancement-type derivatizing reagent for amino compounds. J Fluoresc. 2010;20:615-24 pubmed publisher
  36. Chen J, Chen C, Alevriadou B, Zweier J, Chen Y. Excess no predisposes mitochondrial succinate-cytochrome c reductase to produce hydroxyl radical. Biochim Biophys Acta. 2011;1807:491-502 pubmed publisher
    ..With shear exposure that led to overproduction of NO by the endothelium, SCR-mediated oxygen-free radical production was also detected in cultured vascular endothelial cells...
  37. Thyagarajan B, Poteser M, Romanin C, Kahr H, Zhu M, Groschner K. Expression of Trp3 determines sensitivity of capacitative Ca2+ entry to nitric oxide and mitochondrial Ca2+ handling: evidence for a role of Trp3 as a subunit of capacitative Ca2+ entry channels. J Biol Chem. 2001;276:48149-58 pubmed
    ..Moreover, we show for the first time that Trp3 expression determines biophysical properties as well as regulation of CCE channels by NO and mitochondrial Ca(2+) handling. Thus, we propose Trp3 as a subunit of CCE channels...
  38. Marquez R, Santangelo G, Sastre J, Goldschmidt P, Luyckx J, Pallardo F, et al. Cyanoside chloride and chromocarbe diethylamine are more effective than vitamin C against exercise-induced oxidative stress. Pharmacol Toxicol. 2001;89:255-8 pubmed
    ..Chromocarbe diethylamine was the most effective compound in the prevention of exercise-induced lipid peroxidation (malondialdehyde) in plasma...
  39. Suzuki K, Ito Y, Kanie O. An improved method for the synthesis of protected glycosyl fluorides from thioglycosides using N,N-diethylaminosulfur trifluoride (DAST). Carbohydr Res. 2012;359:81-91 pubmed publisher
  40. Müller E. Comparison between mass transfer properties of weak-anion-exchange resins with graft-functionalized polymer layers and traditional ungrafted resins. J Chromatogr A. 2003;1006:229-40 pubmed
    ..It can be concluded that grafting will increase the capacity and the pore diffusion in batch mode but in column operation the grafting layer has a film resistance which plays an important role in the overall mass transfer...
  41. Ambade A, Satishchandran A, Szabo G. Alcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and miR-122-mediated HIF-1α activation. Sci Rep. 2016;6:21340 pubmed publisher
    ..We conclude that alcoholic steatohepatitis accelerates hepatobiliary tumors with characteristic molecular features of HCC by up-regulating inflammation, cell proliferation, stemness, and miR-122 loss. ..
  42. Karaca G, Tasdemir Y. Removal of polycyclic aromatic hydrocarbons (PAHs) from industrial sludges in the ambient air conditions: automotive industry. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2013;48:855-61 pubmed publisher
    ..PAH removal ratios were 8% and 32% when DEA (20%) and TiO2 (20%) were added, respectively. It was concluded that DEA was a weak photo-sensitizer yet TiO2 was effective only at 20% dosage...
  43. van Och F, Slob W, De Jong W, Vandebriel R, van Loveren H. A quantitative method for assessing the sensitizing potency of low molecular weight chemicals using a local lymph node assay: employment of a regression method that includes determination of the uncertainty margins. Toxicology. 2000;146:49-59 pubmed
    ..The approach performed in this study is a way to accurately assess the potency of sensitizing chemicals and thus a possibility for classification...
  44. Preckel B, Kojda G, Schlack W, Ebel D, Kottenberg K, Noack E, et al. Inotropic effects of glyceryl trinitrate and spontaneous NO donors in the dog heart. Circulation. 1997;96:2675-82 pubmed
  45. Suzuki T, Naka A, Kimura H. Effects of uric acid on nitrosation of N-acetylcysteine by diethylamine NONOate and N-acetyl-N-nitrosotryptophan. Chem Pharm Bull (Tokyo). 2009;57:736-9 pubmed
    ..This implies that uric acid may act as an effective transporter of nitric oxide to thiols resulting in accumulation of nitrosothiols in humans...
  46. Martinez A, Urios A, Felipo V, Blanco M. Mutagenicity of nitric oxide-releasing compounds in Escherichia coli: effect of superoxide generation and evidence for two mutagenic mechanisms. Mutat Res. 2001;497:159-67 pubmed
    ..The results show the usefulness of the new tester strain IC203 to differentiate NO-promoted mutagenic mechanisms that involve or do not involve oxygen radicals...
  47. Chiang H, Sheu S. Analysis of ephedra-alkaloids using sweeping and cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography methods. Electrophoresis. 2004;25:670-6 pubmed
    ..The method is suitable for analyses of dilute herb drug extracts and mouse sera. The effect of buffers on the separation and validation of the methods in this study are also discussed...
  48. Rao R, Raju A, Narsimha R. Isolation and characterization of degradation products of citalopram and process-related impurities using RP-HPLC. J Sep Sci. 2008;31:1729-38 pubmed publisher
    ..The degradation products and unknown impurities were isolated and characterized by ESI-MS/MS, (1)H NMR, and FT-IR spectroscopy...
  49. Abdelhamid H, Gopal J, Wu H. Synthesis and application of ionic liquid matrices (ILMs) for effective pathogenic bacteria analysis in matrix assisted laser desorption/ionization (MALDI-MS). Anal Chim Acta. 2013;767:104-11 pubmed publisher
    ..All synthesized ILMs were characterized using ESI (+)/MS and UV-spectroscopy...
  50. Sharma S, Evans M, Evans S. The enantiomeric separation of metipranolol and desacetylmetipranolol on a cellulose tris-3,5-dimethylphenyl-carbamate chiral stationary phase. J Pharm Biomed Anal. 1995;13:129-37 pubmed
    ..The method affords identification and determination of the optical purity of the bulk drug and its formulated ophthalmic products...
  51. Shiddiky M, Torriero A, Zeng Z, Spiccia L, Bond A. Highly selective and sensitive DNA assay based on electrocatalytic oxidation of ferrocene bearing zinc(II)-cyclen complexes with diethylamine. J Am Chem Soc. 2010;132:10053-63 pubmed publisher
    ..Excellent selectivity against even single-base sequence mismatches is achieved, and the DNA sensor is stable and reusable...
  52. Nti Gyabaah J, Antia F, Dahlgren M, Göklen K. Normal phase high-performance liquid chromatography of pneumocandins: in situ modification of silica with L-proline to separate structural analogues. Biotechnol Prog. 2006;22:538-46 pubmed
    ..Results of a systematic study showed that the amine group in l-proline and other amino acids plays a key role in the modification of the surface of the silica gel to mediate the selectivity enhancement...
  53. Gudmundsdóttir I, McRobbie S, Robinson S, Newby D, Megson I. Sildenafil potentiates nitric oxide mediated inhibition of human platelet aggregation. Biochem Biophys Res Commun. 2005;337:382-5 pubmed