cadaverine

Summary

Summary: A foul-smelling diamine formed by bacterial decarboxylation of lysine.

Top Publications

  1. Bampton E, Goemans C, Niranjan D, Mizushima N, Tolkovsky A. The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo/lysosomes. Autophagy. 2005;1:23-36 pubmed
    ..Use of fluorescent LC3 and a counter-fluorescent endosomal/lysosomal protein clearly allows the entire autophagic process to be followed by live cell imaging with high fidelity...
  2. Mimitsuka T, Sawai H, Hatsu M, Yamada K. Metabolic engineering of Corynebacterium glutamicum for cadaverine fermentation. Biosci Biotechnol Biochem. 2007;71:2130-5 pubmed
    b>Cadaverine, the expected raw material of polyamides, is produced by decarboxylation of L-lysine...
  3. Li M, Li D, Huang Y, Liu M, Wang H, Tang Q, et al. Improving the secretion of cadaverine in Corynebacterium glutamicum by cadaverine-lysine antiporter. J Ind Microbiol Biotechnol. 2014;41:701-9 pubmed publisher
    b>Cadaverine (1,5-pentanediamine, diaminopentane), the desired raw material of bio-polyamides, is an important industrial chemical with a wide range of applications...
  4. Qian Z, Xia X, Lee S. Metabolic engineering of Escherichia coli for the production of cadaverine: a five carbon diamine. Biotechnol Bioeng. 2011;108:93-103 pubmed publisher
    A five carbon linear chain diamine, cadaverine (1,5-diaminopentane), is an important platform chemical having many applications in chemical industry...
  5. Buňková L, Bunka F, Mantlová G, Cablová A, Sedláček I, Svec P, et al. The effect of ripening and storage conditions on the distribution of tyramine, putrescine and cadaverine in Edam-cheese. Food Microbiol. 2010;27:880-8 pubmed publisher
    ..aim of the work was to describe the development of selected biogenic amines (histamine, tyramine, putrescine and cadaverine) in 4 layers of Dutch-type cheese (Edam-cheese) depending on 3 ripening/storage regimes during a 98-day period...
  6. Cacciapuoti G, Porcelli M, Moretti M, Sorrentino F, Concilio L, Zappia V, et al. The first agmatine/cadaverine aminopropyl transferase: biochemical and structural characterization of an enzyme involved in polyamine biosynthesis in the hyperthermophilic archaeon Pyrococcus furiosus. J Bacteriol. 2007;189:6057-67 pubmed publisher
    We report here the characterization of the first agmatine/cadaverine aminopropyl transferase (ACAPT), the enzyme responsible for polyamine biosynthesis from an archaeon...
  7. Samartzidou H, Delcour A. Excretion of endogenous cadaverine leads to a decrease in porin-mediated outer membrane permeability. J Bacteriol. 1999;181:791-8 pubmed
    ..Externally added polyamines, such as cadaverine, decrease porin-mediated fluxes of beta-lactam antibiotics in live cells...
  8. Lavizzari T, Breccia M, Bover Cid S, Vidal Carou M, Veciana Nogués M. Histamine, cadaverine, and putrescine produced in vitro by enterobacteriaceae and pseudomonadaceae isolated from spinach. J Food Prot. 2010;73:385-9 pubmed
    ..Among these isolates, 240 formed cadaverine, 208 formed putrescine, and 196 formed histamine, in widely varying amounts...
  9. Soksawatmaekhin W, Uemura T, Fukiwake N, Kashiwagi K, Igarashi K. Identification of the cadaverine recognition site on the cadaverine-lysine antiporter CadB. J Biol Chem. 2006;281:29213-20 pubmed
    Amino acid residues involved in cadaverine uptake and cadaverine-lysine antiporter activity were identified by site-directed mutagenesis of the CadB protein...

More Information

Publications62

  1. Tateno T, Okada Y, Tsuchidate T, Tanaka T, Fukuda H, Kondo A. Direct production of cadaverine from soluble starch using Corynebacterium glutamicum coexpressing alpha-amylase and lysine decarboxylase. Appl Microbiol Biotechnol. 2009;82:115-21 pubmed publisher
    Here, we demonstrated the one-step production of cadaverine from starch using a Corynebacterium glutamicum strain coexpressing Streptococcus bovis 148 alpha-amylase (AmyA) and Escherichia coli K-12 lysine decarboxylase (CadA)...
  2. Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K. Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli. Mol Microbiol. 2004;51:1401-12 pubmed
    The functions of the putative cadaverine transport protein CadB were studied in Escherichia coli...
  3. McCormick B, Fernandez M, Siber A, Maurelli A. Inhibition of Shigella flexneri-induced transepithelial migration of polymorphonuclear leucocytes by cadaverine. Cell Microbiol. 1999;1:143-55 pubmed
    ..Such inhibition was caused by cadaverine generated from the decarboxylation of lysine...
  4. Hasne M, Coppens I, Soysa R, Ullman B. A high-affinity putrescine-cadaverine transporter from Trypanosoma cruzi. Mol Microbiol. 2010;76:78-91 pubmed publisher
    ..1 and TcPOT1.2 were high-affinity transporters that recognized both putrescine and cadaverine but not spermidine or spermine. Furthermore, the activities and subcellular locations of both TcPOT1...
  5. Aronova E, Sheviakova N, Stetsenko L, Kuznetsov V. Cadaverine-induced induction of superoxide dismutase gene expression in Mesembryanthemum crystallinum L. Dokl Biol Sci. 2005;403:257-9 pubmed
  6. Tabor H, Hafner E, Tabor C. Construction of an Escherichia coli strain unable to synthesize putrescine, spermidine, or cadaverine: characterization of two genes controlling lysine decarboxylase. J Bacteriol. 1980;144:952-6 pubmed
    ..However, these cells contained some cadaverine (1,5-diaminopentane)...
  7. Fernandez I, Silva M, Schuch R, Walker W, Siber A, Maurelli A, et al. Cadaverine prevents the escape of Shigella flexneri from the phagolysosome: a connection between bacterial dissemination and neutrophil transepithelial signaling. J Infect Dis. 2001;184:743-53 pubmed
    ..Our recent studies demonstrated that cadaverine, a polyamine, specifically acts to abrogate transepithelial signaling to PMNL induced by S. flexneri...
  8. Contento A, Xiong Y, Bassham D. Visualization of autophagy in Arabidopsis using the fluorescent dye monodansylcadaverine and a GFP-AtATG8e fusion protein. Plant J. 2005;42:598-608 pubmed
    ..MDC-staining and the GFP-AtATG8e fusion protein can now be used as very effective tools to complement biochemical and genetic approaches to the study of autophagy in plant systems...
  9. Cooke M, Leeves N, White C. Time profile of putrescine, cadaverine, indole and skatole in human saliva. Arch Oral Biol. 2003;48:323-7 pubmed
    The concentrations of putrescine, cadaverine, indole and skatole were determined in the saliva of healthy human volunteers upon waking and at time points during the day...
  10. Samartzidou H, Mehrazin M, Xu Z, Benedik M, Delcour A. Cadaverine inhibition of porin plays a role in cell survival at acidic pH. J Bacteriol. 2003;185:13-9 pubmed
    When grown at acidic pH, Escherichia coli cells secrete cadaverine, a polyamine known to inhibit porin-mediated outer membrane permeability...
  11. Goldberg S, Kozlovsky A, Gordon D, Gelernter I, Sintov A, Rosenberg M. Cadaverine as a putative component of oral malodor. J Dent Res. 1994;73:1168-72 pubmed
    ..In the present investigation, the possibility that diamines (cadaverine and putrescine) are associated with oral malodor parameters was assessed...
  12. Bover Cid S, Torriani S, Gatto V, Tofalo R, Suzzi G, Belletti N, et al. Relationships between microbial population dynamics and putrescine and cadaverine accumulation during dry fermented sausage ripening. J Appl Microbiol. 2009;106:1397-407 pubmed publisher
    ..of three technological variables (fermentation temperature, NaCl and glucose added to the meat batter) on diamines (cadaverine, putrescine and histamine) accumulation and microbial changes during ripening of dry fermented sausages.
  13. Schwartz C, Palissot V, Aouali N, Wack S, Brons N, Leners B, et al. Valproic acid induces non-apoptotic cell death mechanisms in multiple myeloma cell lines. Int J Oncol. 2007;30:573-82 pubmed
    ..We have also studied another mechanism of cell death, the senescence-like phenotype, but did not find any evidence for its implication. Thus, treatment with VPA may imply other alternative cell death mechanisms...
  14. Park M, Wolff E, Smit McBride Z, Hershey J, Folk J. Comparison of the activities of variant forms of eIF-4D. The requirement for hypusine or deoxyhypusine. J Biol Chem. 1991;266:7988-94 pubmed
    ..In a parallel reaction, using N-(3-aminopropyl)cadaverine in place of spermidine, a variant form of eIF-4D containing homodeoxyhypusine (N epsilon-(5-aminopentyl)lysine) ..
  15. Kind S, Jeong W, Schröder H, Zelder O, Wittmann C. Identification and elimination of the competing N-acetyldiaminopentane pathway for improved production of diaminopentane by Corynebacterium glutamicum. Appl Environ Microbiol. 2010;76:5175-80 pubmed publisher
    The present work describes the development of a superior strain of Corynebacterium glutamicum for diaminopentane (cadaverine) production aimed at the identification and deletion of the underlying unknown N-acetyldiaminopentane pathway...
  16. Kim J, Cho T, Woo B, Choi K, Lee C, Ryu M, et al. Curcumin-induced autophagy contributes to the decreased survival of oral cancer cells. Arch Oral Biol. 2012;57:1018-25 pubmed publisher
    ..These findings suggest that curcumin may potentially contribute to oral cancer treatment and provide useful information for the development of a new therapeutic agent...
  17. Soysa R, Venselaar H, Poston J, Ullman B, Hasne M. Structural model of a putrescine-cadaverine permease from Trypanosoma cruzi predicts residues vital for transport and ligand binding. Biochem J. 2013;452:423-32 pubmed publisher
    The TcPOT1.1 gene from Trypanosoma cruzi encodes a high affinity putrescine-cadaverine transporter belonging to the APC (amino acid/polyamine/organocation) transporter superfamily...
  18. Pospieszna Markiewicz I, Radecka Paryzek W, Kubicki M. Cadaverinium dichloride: a case of centro-non-centrosymmetric ambiguity. Acta Crystallogr C. 2006;62:o399-401 pubmed
    ..This structure is another case of centro-non-centrosymmetric ambiguity; the best results were obtained in a centrosymmetric space group, with the disordered NH(3) groups accounting for the non-centrosymmetric 'component'...
  19. Chu J, Leong P, Ng M. Analysis of the endocytic pathway mediating the infectious entry of mosquito-borne flavivirus West Nile into Aedes albopictus mosquito (C6/36) cells. Virology. 2006;349:463-75 pubmed
    ..Finally, a low-pH-dependent step is required for WNV infection as revealed by the resistance of C6/36 cells to WNV infection in the presence of lysosomotropic agents...
  20. Legaz M, Pedrosa M. Effect of polyamines on the separation of ovalbumin glycoforms by capillary electrophoresis. J Chromatogr A. 1996;719:159-70 pubmed
    ..0) containing 0.87 mM spermidine or 0.14 mM spermine. The effects of different concentrations of putrescine, cadaverine, spermidine, spermine and some monoamines or diamines are compared in terms of selectivity factors of ovalbumin ..
  21. Le M, Gohr C, Rosenthal A. Transglutaminase participates in the incorporation of latent TGFbeta into the extracellular matrix of aging articular chondrocytes. Connect Tissue Res. 2001;42:245-53 pubmed
    ..Extracellular TGase activity was present in old but not young chondrocyte cultures. These findings support a role for extracellular TGase in the incorporation of LTGFbeta1 in the ECM of aging chondrocytes...
  22. Mei Y, Ran L, Ying X, Yuan Z, Xin S. A sequential injection analysis/chemiluminescent plant tissue-based biosensor system for the determination of diamine. Biosens Bioelectron. 2007;22:871-6 pubmed
    ..The analysis of diamines, such as putrescine and cadaverine, is based on an enzymatic conversion which takes place in the plant tissue column to produce hydrogen peroxide...
  23. Laranjo M, Gomes A, Agulheiro Santos A, Potes M, Cabrita M, Garcia R, et al. Impact of salt reduction on biogenic amines, fatty acids, microbiota, texture and sensory profile in traditional blood dry-cured sausages. Food Chem. 2017;218:129-136 pubmed publisher
    ..86 to 796.68mgkg-1 fresh matter, with higher amounts, particularly of cadaverine, histamine and tyramine, in low-salt products...
  24. Rosenberg M, Kozlovsky A, Gelernter I, Cherniak O, Gabbay J, Baht R, et al. Self-estimation of oral malodor. J Dent Res. 1995;74:1577-82 pubmed
    ..plaque index, gingival index, and probing depth); (iv) volatile sulphide levels; (v) salivary cadaverine levels; and (vi) intra-oral trypsin-like activity...
  25. De Filippis F, Pennacchia C, Di Pasqua R, Fiore A, Fogliano V, Villani F, et al. Decarboxylase gene expression and cadaverine and putrescine production by Serratia proteamaculans in vitro and in beef. Int J Food Microbiol. 2013;165:332-8 pubmed publisher
    ..genes was evaluated by quantitative reverse transcription-PCR (qRT-PCR), while the presence of cadaverine and putrescine was quantified by LC-ESI-MS/MS...
  26. Aeschlimann D, Kaupp O, Paulsson M. Transglutaminase-catalyzed matrix cross-linking in differentiating cartilage: identification of osteonectin as a major glutaminyl substrate. J Cell Biol. 1995;129:881-92 pubmed
    ..e., cross-linking of osteonectin in situ, shows that tissue transglutaminase-catalyzed cross-linking is a physiological mechanism for cartilage matrix stabilization...
  27. Liao B, Sram J, Cain T, Halcrow K. Aqueous sulfuric acid as the mobile phase in cation ion chromatography for determination of histamine, putrescine, and cadaverine in fish samples. J AOAC Int. 2011;94:565-71 pubmed
    ..can be used as the mobile phase in cation ion chromatography to separate the three biogenic amines, putrescine, cadaverine, and histamine, from fish...
  28. Zhang J, Li Y, Chen X, Liu T, Chen Y, He W, et al. Autophagy is involved in anticancer effects of matrine on SGC-7901 human gastric cancer cells. Oncol Rep. 2011;26:115-24 pubmed publisher
    ..These ?ndings indicate that matrine is a potent antitumor agent for treating gastric cancer. The ability of matrine to induce autophagy underlines its potential utility as a new gastric cancer treatment modality...
  29. Kojima S, Kaneko J, Abe N, Takatsuka Y, Kamio Y. Cadaverine covalently linked to the peptidoglycan serves as the correct constituent for the anchoring mechanism between the outer membrane and peptidoglycan in Selenomonas ruminantium. J Bacteriol. 2011;193:2347-50 pubmed publisher
    In Selenomonas ruminantium, a strictly anaerobic and gram-negative bacterium, cadaverine covalently linked to the peptidoglycan is required for the interaction between the peptidoglycan and the S-layer homologous (SLH) domain of the major ..
  30. Akematsu T, Pearlman R, Endoh H. Gigantic macroautophagy in programmed nuclear death of Tetrahymena thermophila. Autophagy. 2010;6:901-11 pubmed publisher
  31. G mez Flores E, S nchez Guzm n E, Castro Mu ozledo F. Asymmetrical cell division and differentiation are not dependent upon stratification in a corneal epithelial cell line. J Cell Physiol. 2011;226:700-9 pubmed publisher
    ..They also suggest that asymmetric division does not depend on stratification; instead, it seems to be part of the differentiation program...
  32. Luhová L, Slavik L, Frebort I, Sebela M, Zajoncova L, Pec P. Comparison of kinetic properties between plant and fungal amine oxidases. J Enzyme Inhib. 1996;10:251-262 pubmed
    ..4.3.6). Pea amine oxidase showed highest affinity with diamines, such as putrescine and cadaverine, while fungal enzymes oxidized preferably n-hexylamine and tyramine...
  33. Zhang Q, Mosher D. Cross-linking of the NH2-terminal region of fibronectin to molecules of large apparent molecular mass. Characterization of fibronectin assembly sites induced by the treatment of fibroblasts with lysophosphatidic acid. J Biol Chem. 1996;271:33284-92 pubmed
    ..Thus, cell surface molecules that are either very large or not dissociated in sodium dodecyl sulfate comprise the labile matrix assembly sites for fibronectin...
  34. Zhao X, Jiao X, Xia M, Liu Q, Zhang J. [Determination of five biogenic amines in source water by ion chromatography]. Se Pu. 2009;27:505-8 pubmed
    ..IC) method was developed for the separation of five biogenic amines (BAs), including putrescine, cadaverine, histamine, spermidine and spermine, in source water...
  35. Bourke E, Cassetti A, Villa A, Fadlon E, Colotta F, Mantovani A. IL-1 beta scavenging by the type II IL-1 decoy receptor in human neutrophils. J Immunol. 2003;170:5999-6005 pubmed
    ..These results suggest that the decoy receptor IL-1RII can act as a scavenger of IL-1, representing a novel autoregulatory mechanism of the IL-1 system...
  36. Huff T, Rosorius O, Otto A, Müller C, Ballweber E, Hannappel E, et al. Nuclear localisation of the G-actin sequestering peptide thymosin beta4. J Cell Sci. 2004;117:5333-41 pubmed
    ..It can be selectively labelled at two of its glutamine-residues with fluorescent Oregon Green cadaverine using transglutaminase; however, this labelling does not interfere with its interaction with G-actin...
  37. Nishino N, Hattori H, Wada H, Touno E. Biogenic amine production in grass, maize and total mixed ration silages inoculated with Lactobacillus casei or Lactobacillus buchneri. J Appl Microbiol. 2007;103:325-32 pubmed
    ..To investigate the effects of inoculating Lactobacillus casei or Lacobacillus buchneri on the production of biogenic amines (BA) in silage...
  38. Nunomura K, Kawakami S, Shimizu T, Hara T, Nakamura K, Terakawa Y, et al. In vivo cross-linking of nucleosomal histones catalyzed by nuclear transglutaminase in starfish sperm and its induction by egg jelly triggering the acrosome reaction. Eur J Biochem. 2003;270:3750-9 pubmed
    ..This is the first demonstration of an in vivo activation of transglutaminase leading to the formation of a cross-link in intracellular proteins...
  39. Sedgwick B. Nitrosated peptides and polyamines as endogenous mutagens in O6-alkylguanine-DNA alkyltransferase deficient cells. Carcinogenesis. 1997;18:1561-7 pubmed
    ..Nitrosated peptides and polyamines are therefore potential endogenous mutagens that are harmful particularly in O6-alkylguanine-DNA alkyltransferase deficient cells...
  40. Zheng Q, Li Z, Zhou S, Zhang Q, Zhou L, Fu X, et al. Heparin-binding Hemagglutinin of Mycobacterium tuberculosis Is an Inhibitor of Autophagy. Front Cell Infect Microbiol. 2017;7:33 pubmed publisher
    ..These findings suggested that rMS-HBHA could inhibit autophagy, promote its survival and replication within A549 cells, and subsequently induce apoptosis on infected cells to facilitate infection...
  41. Katikou P, Georgantelis D, Paleologos E, Ambrosiadis I, Kontominas M. Relation of biogenic amines' formation with microbiological and sensory attributes in Lactobacillus-inoculated vacuum-packed rainbow trout (Oncorhynchus mykiss) fillets. J Agric Food Chem. 2006;54:4277-83 pubmed
    ..Eight amines, namely putrescine, cadaverine, tyramine, tryptamine, beta-phenylethylamine, histamine, spermine, and spermidine, were determined, whereas ..
  42. Madrid R, Delgado R, Bacigalupo J. Cyclic AMP cascade mediates the inhibitory odor response of isolated toad olfactory receptor neurons. J Neurophysiol. 2005;94:1781-8 pubmed
    ..We conclude that a cAMP cascade mediates the activation of the ciliary Ca2+-dependent K+ current and that the Ca2+ ions that activate the inhibitory current enter the cilia through CNG channels...
  43. Baranger K, Zani M, Labas V, Dallet Choisy S, Moreau T. Secretory leukocyte protease inhibitor (SLPI) is, like its homologue trappin-2 (pre-elafin), a transglutaminase substrate. PLoS ONE. 2011;6:e20976 pubmed publisher
    ..We have thus added to the corpus of knowledge on the biology of these potential therapeutic inhibitors of airway proteases...
  44. Jans R, Sturniolo M, Eckert R. Localization of the TIG3 transglutaminase interaction domain and demonstration that the amino-terminal region is required for TIG3 function as a keratinocyte differentiation regulator. J Invest Dermatol. 2008;128:517-29 pubmed
  45. Dela Vega A, Delcour A. Polyamines decrease Escherichia coli outer membrane permeability. J Bacteriol. 1996;178:3715-21 pubmed
    ..We tested the effects of four polyamines (putrescine, cadaverine, spermidine, and spermine) on two processes known to depend on intact porin function: fluxes of beta-lactam ..
  46. Miserus R, Herias M, Prinzen L, Lobbes M, van Suylen R, Dirksen A, et al. Molecular MRI of early thrombus formation using a bimodal alpha2-antiplasmin-based contrast agent. JACC Cardiovasc Imaging. 2009;2:987-96 pubmed publisher
    ..We aimed to investigate whether early thrombus formation can be visualized with in vivo magnetic resonance imaging (MRI) by the use of a novel bimodal alpha(2)-antiplasmin-based contrast agent (CA)...
  47. Chan J, Li L, Miao J, Cai D, Lee K, Chui Y. Differential expression of a novel gene BRE (TNFRSF1A modulator/BRCC45) in response to stress and biological signals. Mol Biol Rep. 2010;37:363-8 pubmed publisher
    ..Although BRE plays a regulatory role in many different pathways, yet its expression is apparently under very stringent control...
  48. Ben Gigirey B, Vieites Baaptista de Sousa J, Villa T, Barros Velazquez J. Histamine and cadaverine production by bacteria isolated from fresh and frozen albacore (Thunnus alalunga). J Food Prot. 1999;62:933-9 pubmed
    ..8 ppm after 6 days. Three S. maltophilia strains showed strong lysine-decarboxylating activity. Their cadaverine formation capacity was determined by high-pressure liquid chromatography in tryptic soy broth supplemented with ..
  49. Cui Q, Tashiro S, Onodera S, Minami M, Ikejima T. Oridonin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and P38 regulation. J Pharmacol Sci. 2007;105:317-25 pubmed
    ..Raf-1 and ERK1/2 had no obvious correlation to these signaling pathways...
  50. Buschke N, Schröder H, Wittmann C. Metabolic engineering of Corynebacterium glutamicum for production of 1,5-diaminopentane from hemicellulose. Biotechnol J. 2011;6:306-17 pubmed publisher
    In the present work, the bio-based production of 1,5-diaminopentane (cadaverine), an important building block for bio-polyamides, was extended to hemicellulose a non-food raw material...
  51. Ye W, Zhu W, Xu K, Liang A, Peng Y, Huang D, et al. Increased macroautophagy in the pathological process of intervertebral disc degeneration in rats. Connect Tissue Res. 2013;54:22-8 pubmed publisher
    ..Additionally, in vitro evidence of macroautophagy and GRP78 and GADD153 protein levels were investigated to explore the mechanism of macroautophagy in the process of IVDD...
  52. Egberts F, Heinrich M, Jensen J, Winoto Morbach S, Pfeiffer S, Wickel M, et al. Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation. J Cell Sci. 2004;117:2295-307 pubmed
    ..Our findings suggest a functional link between cathepsin D activation, transglutaminase 1 activity and protein expression of cornified envelope proteins during epidermal differentiation...
  53. Solomon Zemler R, Sarfstein R, Werner H. Nuclear insulin-like growth factor-1 receptor (IGF1R) displays proliferative and regulatory activities in non-malignant cells. PLoS ONE. 2017;12:e0185164 pubmed publisher
    ..In conclusion, results are consistent with the concept that nuclear IGF1R fulfills important physiological and pathological roles. ..