biogenic monoamines

Summary

Summary: Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.

Top Publications

  1. Berton O, Nestler E. New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci. 2006;7:137-51 pubmed
    ..This review summarizes the obstacles that have hindered the development of non-monoamine-based antidepressants, and provides a progress report on some of the most promising current strategies...
  2. Walther D, Stahlberg S, Vowinckel J. Novel roles for biogenic monoamines: from monoamines in transglutaminase-mediated post-translational protein modification to monoaminylation deregulation diseases. FEBS J. 2011;278:4740-55 pubmed publisher
    ..Furthermore, the potential regulatory roles of protein monoaminylation in small GTPase, heterotrimeric G-protein and lipid signaling, as well as in modulating metabolic enzymes and nuclear processes, are critically assessed...
  3. Cikos S, Fabian D, Makarevich A, Chrenek P, Koppel J. Biogenic monoamines in preimplantation development. Hum Reprod. 2011;26:2296-305 pubmed publisher
    The involvement of biogenic monoamines in early ('preneural') embryogenesis has been well documented in lower vertebrates, but much less information is available about the role of these molecules in the earliest stages of development in ..
  4. Obata H, Kimura M, Nakajima K, Tobe M, Nishikawa K, Saito S. Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in rats. J Pharmacol Exp Ther. 2010;334:1059-65 pubmed publisher
    ..Combined administration of an SNRI with morphine might be a promising treatment to suppress postoperative hypersensitivity...
  5. Rascol O, Poewe W, Lees A, Aristin M, Salin L, Juhel N, et al. Tesofensine (NS 2330), a monoamine reuptake inhibitor, in patients with advanced Parkinson disease and motor fluctuations: the ADVANS Study. Arch Neurol. 2008;65:577-83 pubmed publisher
    ..To assess the safety and efficacy of tesofensine, a triple monoamine reuptake inhibitor, in patients with advanced Parkinson disease (PD)...
  6. Witkin J, Marek G, Johnson B, Schoepp D. Metabotropic glutamate receptors in the control of mood disorders. CNS Neurol Disord Drug Targets. 2007;6:87-100 pubmed
  7. Lecourtier L, Kelly P. A conductor hidden in the orchestra? Role of the habenular complex in monoamine transmission and cognition. Neurosci Biobehav Rev. 2007;31:658-72 pubmed
    ..Electrophysiological studies indicate a role in metaplasticity, the modulation of neuroplasticity. These studies thus reveal important roles of the habenular complex in learning, memory and attention...
  8. Hisaoka K, Takebayashi M, Tsuchioka M, Maeda N, Nakata Y, Yamawaki S. Antidepressants increase glial cell line-derived neurotrophic factor production through monoamine-independent activation of protein tyrosine kinase and extracellular signal-regulated kinase in glial cells. J Pharmacol Exp Ther. 2007;321:148-57 pubmed
  9. Ruhé H, Mason N, Schene A. Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies. Mol Psychiatry. 2007;12:331-59 pubmed
    ..They presumably clarify a vulnerability trait to become depressed. Directions for further investigation of this vulnerability trait are proposed...

More Information

Publications62

  1. Williams M, Herring N, Schaefer T, Skelton M, Campbell N, Lipton J, et al. Alterations in body temperature, corticosterone, and behavior following the administration of 5-methoxy-diisopropyltryptamine ('foxy') to adult rats: a new drug of abuse. Neuropsychopharmacology. 2007;32:1404-20 pubmed
    ..5-MEO-DIPT may have the potential to induce untoward effects in humans...
  2. Juric D, Miklic S, Carman Krzan M. Monoaminergic neuronal activity up-regulates BDNF synthesis in cultured neonatal rat astrocytes. Brain Res. 2006;1108:54-62 pubmed
  3. Stephenson D, Meglasson M, Connell M, Childs M, Hajos Korcsok E, Emborg M. The effects of a selective dopamine D2 receptor agonist on behavioral and pathological outcome in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated squirrel monkeys. J Pharmacol Exp Ther. 2005;314:1257-66 pubmed
    ..These results suggest that sumanirole can exert antiparkinsonian effects similar to L-DOPA without the behavioral and morphological consequences of the latter...
  4. Hikosaka O, Sesack S, Lecourtier L, Shepard P. Habenula: crossroad between the basal ganglia and the limbic system. J Neurosci. 2008;28:11825-9 pubmed publisher
    ..Further, dysfunctions of the LHb have also been implicated in psychiatric disorders, such as depression, schizophrenia, and drug-induced psychosis...
  5. Aboukhatwa M, Undieh A. Antidepressant stimulation of CDP-diacylglycerol synthesis does not require monoamine reuptake inhibition. BMC Neurosci. 2010;11:10 pubmed publisher
  6. Barbosa Neto J, Tiba P, Faturi C, de Castro Neto E, da Graça Naffah Mazacoratti M, de Jesus Mari J, et al. Stress during development alters anxiety-like behavior and hippocampal neurotransmission in male and female rats. Neuropharmacology. 2012;62:518-26 pubmed publisher
    ..This article is part of a Special Issue entitled 'Anxiety and Depression'...
  7. Amo R, Aizawa H, Takahoko M, Kobayashi M, Takahashi R, Aoki T, et al. Identification of the zebrafish ventral habenula as a homolog of the mammalian lateral habenula. J Neurosci. 2010;30:1566-74 pubmed publisher
    ..These findings indicated that the lateral habenular pathways are evolutionarily conserved pathways and might control adaptive behaviors in vertebrates through the regulation of monoaminergic activities...
  8. Schmidt Wilcke T, Clauw D. Pharmacotherapy in fibromyalgia (FM)--implications for the underlying pathophysiology. Pharmacol Ther. 2010;127:283-94 pubmed publisher
    ..Further we discuss some of the potential targets that have been recently identified that may hold promise for the development of novel treatments...
  9. Litteljohn D, Cummings A, Brennan A, Gill A, Chunduri S, Anisman H, et al. Interferon-gamma deficiency modifies the effects of a chronic stressor in mice: Implications for psychological pathology. Brain Behav Immun. 2010;24:462-73 pubmed publisher
    ..At the same time, however, IFN-gamma deficiency appears to blunt some of the neurochemical, corticoid and cytokine alterations ordinarily associated with chronic stressor exposure...
  10. Ash E, Alavijeh M, Palmer A, Mitchelmore C, Howlett D, Francis P, et al. Neurochemical changes in a double transgenic mouse model of Alzheimer's disease fed a pro-oxidant diet. Neurochem Int. 2010;57:504-11 pubmed publisher
    ..The decreased cerebellar levels of HVA and turnover of DA in TASTPM mice hint at possible axonal degeneration within this subregion...
  11. Said U, Saada H, Abd Alla M, Elsayed M, Amin A. Hesperidin attenuates brain biochemical changes of irradiated rats. Int J Radiat Biol. 2012;88:613-8 pubmed publisher
    ..The purpose of this study was to evaluate the efficacy of hesperidin (HES), a citrus flavonoid, against the severity of biochemical disorders in the cerebral hemispheres of irradiated rats...
  12. Mizutani K, Sonoda S, Karasawa N, Yamada K, Shimpo K, Chihara T, et al. Effects of exercise after focal cerebral cortex infarction on basal ganglion. Neurol Sci. 2013;34:861-7 pubmed publisher
    ..In the present study, at least some of the alterations of monoamines associated with the improvement of paralysis in the basal ganglion related to motor control might have been detected...
  13. Geday J, Gjedde A. Monoaminergic modulation of emotional impact in the inferomedial prefrontal cortex. Synapse. 2009;63:160-6 pubmed publisher
    ..We propose a specific pharmacodynamic mechanism that explains the correlation between the emotional impact and the effect of a serotonin-noradrenaline reuptake inhibitor on cerebral blood flow...
  14. Roche M, Kerr D, Hunt S, Kelly J. Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression. Behav Brain Res. 2012;228:91-8 pubmed publisher
    ..The present studies indicate that alterations in substance P/NK1 receptor system underlie, at least in part, the behavioural and monoaminergic changes in this animal model of depression...
  15. Smeland O, Meisingset T, Borges K, Sonnewald U. Chronic acetyl-L-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice. Neurochem Int. 2012;61:100-7 pubmed publisher
    ..In conclusion, chronic ALCAR supplementation decreased glucose metabolism to lactate, resulted in increased energy metabolite and altered monoamine neurotransmitter levels in the mouse brain...
  16. Bohnen N, Muller M, Kotagal V, Koeppe R, Kilbourn M, Albin R, et al. Olfactory dysfunction, central cholinergic integrity and cognitive impairment in Parkinson's disease. Brain. 2010;133:1747-54 pubmed publisher
    ..Greater deficits in odour identification may identify patients with Parkinson's disease at risk for clinically significant cognitive impairment...
  17. Walker A, Burnett S, Hasebe K, McGillivray J, Gray L, McGee S, et al. Chronic adrenocorticotrophic hormone treatment alters tricyclic antidepressant efficacy and prefrontal monoamine tissue levels. Behav Brain Res. 2013;242:76-83 pubmed publisher
    ..These results suggest that chronic ACTH treatment is a promising paradigm for elucidation of mechanisms mediating antidepressant treatment resistance...
  18. Huang S, Zhang X, Wang Y, Pan J, Cui H, Fang S, et al. Effects of Kaixin Jieyu Decoction () on behavior, monoamine neurotransmitter levels, and serotonin receptor subtype expression in the brain of a rat depression model. Chin J Integr Med. 2014;20:280-5 pubmed publisher
  19. Romano A, Pace L, Tempesta B, Lavecchia A, Macheda T, Bedse G, et al. Depressive-like behavior is paired to monoaminergic alteration in a murine model of Alzheimer's disease. Int J Neuropsychopharmacol. 2014;18: pubmed publisher
    ..These results suggest that 3×Tg-AD mice exhibit changes in depression-related behavior involving aminergic neurotrasmitters and provide an animal model for investigating AD with depression. ..
  20. Mathes W, Nehrenberg D, Gordon R, Hua K, Garland T, Pomp D. Dopaminergic dysregulation in mice selectively bred for excessive exercise or obesity. Behav Brain Res. 2010;210:155-63 pubmed publisher
  21. Riss P, Hummerich R, Schloss P. Synthesis and monoamine uptake inhibition of conformationally constrained 2beta-carbomethoxy-3beta-phenyl tropanes. Org Biomol Chem. 2009;7:2688-98 pubmed publisher
    ..A SAR-study was conducted to determine the contribution of extended, 4-fluorinated, conformationally constrained C4 chains at the tropane nitrogen to human monoamine transporter affinity and selectivity...
  22. Lu L, Mamiya T, Lu P, Niwa M, Mouri A, Zou L, et al. The long-lasting effects of cross-fostering on the emotional behavior in ICR mice. Behav Brain Res. 2009;198:172-8 pubmed publisher
    ..These findings suggested that the early-life stress of cross-fostering induced long-lasting emotional abnormalities, which might be possibly related to alterations of serotonin metabolisms...
  23. Nagasawa M, Murakami T, Tomonaga S, Sato M, Takahata Y, Morimatsu F, et al. Impacts of acute imipramine treatment on plasma and brain amino acid metabolism in mice given graded levels of dietary chicken protein. Anim Sci J. 2012;83:777-87 pubmed publisher
    ..In conclusion, the metabolism of several amino acids in the plasma and brain were altered by dietary chicken protein...
  24. Mendez P, Pazienti A, Szabo G, Bacci A. Direct alteration of a specific inhibitory circuit of the hippocampus by antidepressants. J Neurosci. 2012;32:16616-28 pubmed publisher
    ..This differential effect, shared by two types of antidepressants, suggests a new mechanism of action of these medications, and a possible role of perisomatic inhibition in depressive disorders...
  25. Silver H, Chertkow Y, Weinreb O, Danovich L, Youdim M. Multifunctional pharmacotherapy: what can we learn from study of selective serotonin reuptake inhibitor augmentation of antipsychotics in negative-symptom schizophrenia?. Neurotherapeutics. 2009;6:86-93 pubmed publisher
    ..Although as yet limited in scope, the findings of definable molecular targets for synergistic SSRI-antipsychotic interaction provide new directions to inform future research and provide novel bio-molecular targets for drug development...
  26. Liu H, Zeng L, Kong X, Zhu I, Ma Y. [Effects of Chinese herbal compound on monoamine and neuronal amino acids in rat's telencephalon in the course of exhaustion and recovery process]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2011;27:439-43 pubmed
  27. Bauer C, Banks M, Blough B, Negus S. Rate-dependent effects of monoamine releasers on intracranial self-stimulation in rats: implications for abuse liability assessment. Behav Pharmacol. 2013;24:448-58 pubmed publisher
  28. Yan F, Hester P, Enneking S, Cheng H. Effects of perch access and age on physiological measures of stress in caged White Leghorn pullets. Poult Sci. 2013;92:2853-9 pubmed publisher
    ..49, respectively). These results indicated that age, but not perch access, affects neuroendocrine homeostasis in White Leghorn pullets. Pullets that were never exposed to perches showed no evidence of eliciting a stress response. ..
  29. Picciotto M, Brabant C, Einstein E, Kamens H, Neugebauer N. Effects of galanin on monoaminergic systems and HPA axis: Potential mechanisms underlying the effects of galanin on addiction- and stress-related behaviors. Brain Res. 2010;1314:206-18 pubmed publisher
    ..Understanding the mechanisms underlying galanin's effects on neuronal function in brain regions related to stress and addiction may be useful in developing novel therapeutics for the treatment of stress- and addiction-related disorders...
  30. Carroll F, Muresan A, Blough B, Navarro H, Mascarella S, Eaton J, et al. Synthesis of 2-(substituted phenyl)-3,5,5-trimethylmorpholine analogues and their effects on monoamine uptake, nicotinic acetylcholine receptor function, and behavioral effects of nicotine. J Med Chem. 2011;54:1441-8 pubmed publisher
    ..Collectively, these findings illuminate mechanisms of action of 2 analogues and identify deshydroxybupropion analogues 5a-5h as possibly superior candidates as aids to smoking cessation...
  31. Scholl J, Renner K, Forster G, Tejani Butt S. Central monoamine levels differ between rat strains used in studies of depressive behavior. Brain Res. 2010;1355:41-51 pubmed publisher
    ..Overall, these results imply that decreased monoamine levels, combined with alterations in transporter sites, may be related to the predisposition of WKY rats towards depressive behavior...
  32. Tian J, Cui Y, Hu L, Gao S, Chi W, Dong T, et al. Antidepressant-like effect of genipin in mice. Neurosci Lett. 2010;479:236-9 pubmed publisher
    ..The results suggest that compared with fluoxetine, genipin exerts antidepressant-like effects significantly. A possible mechanism, at least in part, is the regulation of the 5-HT and NE levels in the hippocampus...
  33. Zamanian M, Agbedanu P, Wheeler N, McVeigh P, Kimber M, Day T. Novel RNAi-mediated approach to G protein-coupled receptor deorphanization: proof of principle and characterization of a planarian 5-HT receptor. PLoS ONE. 2012;7:e40787 pubmed publisher
    ..Future work can help optimize and adapt this protocol for higher-throughput platforms as well as other phyla...
  34. McEwen B, Chattarji S, Diamond D, Jay T, Reagan L, Svenningsson P, et al. The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation. Mol Psychiatry. 2010;15:237-49 pubmed publisher
    ..Converging lines of evidences demonstrate actions of tianeptine on the glutamatergic system, and therefore offer new insights into how tianeptine may be useful in the treatment of depressive disorders...
  35. Shen F, Tsuruda P, Smith J, Obedencio G, Martin W. Relative contributions of norepinephrine and serotonin transporters to antinociceptive synergy between monoamine reuptake inhibitors and morphine in the rat formalin model. PLoS ONE. 2013;8:e74891 pubmed publisher
    ..Thus, in the rat formalin model, the balance between norepinephrine and serotonin transporter inhibition influences the degree of antinociceptive synergy observed between monoamine reuptake inhibitors and morphine. ..
  36. Balcioglu A, Ren J, McCarthy D, Spencer T, Biederman J, Bhide P. Plasma and brain concentrations of oral therapeutic doses of methylphenidate and their impact on brain monoamine content in mice. Neuropharmacology. 2009;57:687-93 pubmed publisher
  37. Kinawy A. Impact of gasoline inhalation on some neurobehavioural characteristics of male rats. BMC Physiol. 2009;9:21 pubmed publisher
    ..The effect of gasoline exposure on the aggressive behaviour tests was also studied...
  38. Manta S, El Mansari M, Debonnel G, Blier P. Electrophysiological and neurochemical effects of long-term vagus nerve stimulation on the rat monoaminergic systems. Int J Neuropsychopharmacol. 2013;16:459-70 pubmed publisher
  39. Phillips Farfán B, Fernandez Guasti A. Endocrine, neural and pharmacological aspects of sexual satiety in male rats. Neurosci Biobehav Rev. 2009;33:442-55 pubmed publisher
    ..These data suggest that changes in steroid receptors, possibly triggered by modifications in neurotransmitters, underlie at least partly the inhibition of copulatory behavior characteristic of rat sexual satiety...
  40. Halpin L, Yamamoto B. Peripheral ammonia as a mediator of methamphetamine neurotoxicity. J Neurosci. 2012;32:13155-63 pubmed
  41. Liu Y, Yoo M, Savonenko A, Stirling W, Price D, Borchelt D, et al. Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease. J Neurosci. 2008;28:13805-14 pubmed publisher
    ..Our results show that a transgenic mouse model of Abeta pathology develops progressive MAergic neurodegeneration occurring in AD cases...
  42. Pehrson A, Cremers T, Bétry C, van der Hart M, Jørgensen L, Madsen M, et al. Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters--a rat microdialysis and electrophysiology study. Eur Neuropsychopharmacol. 2013;23:133-45 pubmed publisher
    ..In conclusion, Lu AA21004, acting via two pharmacological modalities, 5-HT receptor modulation and SERT inhibition, results in a brain region-dependent increase of multiple neurotransmitter concentrations...
  43. Sano Y, Ornthanalai V, Yamada K, Homma C, Suzuki H, Suzuki T, et al. X11-like protein deficiency is associated with impaired conflict resolution in mice. J Neurosci. 2009;29:5884-96 pubmed publisher
    ..These findings suggest that X11L is involved in the development of neuronal circuits that contribute to conflict resolution...
  44. Kaufman W, Flynn P, Reynolds S. Cuticular plasticization in the tick, Amblyomma hebraeum (Acari: Ixodidae): possible roles of monoamines and cuticular pH. J Exp Biol. 2010;213:2820-31 pubmed publisher
    ..hebraeum is related to hydration, and involves the transport of H(+) ions into the sub-cuticular space by cells in the hypodermis. Feeding-induced plasticization was not observed in the rapid feeding tick, O. moubata...
  45. Yamamura S, Ohoyama K, Hamaguchi T, Kashimoto K, Nakagawa M, Kanehara S, et al. Effects of quetiapine on monoamine, GABA, and glutamate release in rat prefrontal cortex. Psychopharmacology (Berl). 2009;206:243-58 pubmed publisher
    ..The atypical antipsychotic drug, quetiapine (QTP), is effective in schizophrenia and mood disorders, but induces seizures compared to typical antipsychotics...
  46. Nagasawa M, Ogino Y, Kurata K, Otsuka T, Yoshida J, Tomonaga S, et al. Hypothesis with abnormal amino acid metabolism in depression and stress vulnerability in Wistar Kyoto rats. Amino Acids. 2012;43:2101-11 pubmed publisher
    ..Therefore, we hypothesized that abnormalities in amino acid and monoamine metabolism may induce depression, and amino acid metabolism in the brain may be related to stress vulnerability...
  47. Cardoso C, Lobato K, Binfaré R, Ferreira P, Rosa A, Santos A, et al. Evidence for the involvement of the monoaminergic system in the antidepressant-like effect of magnesium. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:235-42 pubmed publisher
  48. Hamed S, Elserogy Y, Abd Elhafeez H. Psychopathological and peripheral levels of neurobiological correlates of obsessive-compulsive symptoms in patients with epilepsy: a hospital-based study. Epilepsy Behav. 2013;27:409-15 pubmed publisher
    ..This work aimed at determining the risks and comorbidities (psychopathological and neurobiological correlates) of OCSs in treated adults with idiopathic epilepsy recruited from a university hospital...
  49. Rastogi M, Ojha R, Prabu P, Devi B, Agrawal A, Dubey G. Prevention of age-associated neurodegeneration and promotion of healthy brain ageing in female Wistar rats by long term use of bacosides. Biogerontology. 2012;13:183-95 pubmed publisher
    ..The results of the present study suggest that bacosides may act as a potential therapeutic intervention in forestalling the deleterious effects of ageing and preventing the age associated pathologies like SDAT...
  50. Schwendt M, Rocha A, See R, Pacchioni A, McGinty J, Kalivas P. Extended methamphetamine self-administration in rats results in a selective reduction of dopamine transporter levels in the prefrontal cortex and dorsal striatum not accompanied by marked monoaminergic depletion. J Pharmacol Exp Ther. 2009;331:555-62 pubmed publisher
    ..Greater understanding of the neuroadaptations underlying persistent methamphetamine seeking and cognitive deficits could yield targets suitable for future therapeutic interventions...
  51. Flames N, Hobert O. Transcriptional control of the terminal fate of monoaminergic neurons. Annu Rev Neurosci. 2011;34:153-84 pubmed publisher
  52. Prediger R, Aguiar A, Moreira E, Matheus F, Castro A, Walz R, et al. The intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a new rodent model to test palliative and neuroprotective agents for Parkinson's disease. Curr Pharm Des. 2011;17:489-507 pubmed
  53. Pavese N, Moore R, Scherfler C, Khan N, Hotton G, Quinn N, et al. In vivo assessment of brain monoamine systems in parkin gene carriers: a PET study. Exp Neurol. 2010;222:120-4 pubmed publisher
    ..These findings suggest that parkin patients and IPD patients with similar striatal dysfunction have different patterns of monoaminergic involvement, with more widespread dysfunction in IPD...