biogenic amines

Summary

Summary: A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.

Top Publications

  1. Mbarki R, Ben Miloud N, Selmi S, Dhib S, Sadok S. Effect of vacuum packaging and low-dose irradiation on the microbial, chemical and sensory characteristics of chub mackerel (Scomber japonicus). Food Microbiol. 2009;26:821-6 pubmed publisher
    ..The control and the treated packs were analyzed periodically for chemical (TMA, TBARS, biogenic amines) and microbial characteristics...
  2. Flora S, Mittal M, Mishra D. Co-exposure to arsenic and fluoride on oxidative stress, glutathione linked enzymes, biogenic amines and DNA damage in mouse brain. J Neurol Sci. 2009;285:198-205 pubmed publisher
    We studied the effects of combined exposure to arsenic and fluoride on (i) brain biogenic amines, oxidative stress and its correlation with glutathione and linked enzymes; (ii) alterations in the structural integrity of DNA; and (iii) ..
  3. Brembs B, Christiansen F, Pflüger H, Duch C. Flight initiation and maintenance deficits in flies with genetically altered biogenic amine levels. J Neurosci. 2007;27:11122-31 pubmed
    ..These findings are consistent with a complex system of multiple amines orchestrating the control of motor behaviors on multiple levels rather than single amines eliciting single behaviors...
  4. Arena M, Romano A, Capozzi V, Beneduce L, Ghariani M, Grieco F, et al. Expression of Lactobacillus brevis IOEB 9809 tyrosine decarboxylase and agmatine deiminase genes in wine correlates with substrate availability. Lett Appl Microbiol. 2011;53:395-402 pubmed publisher
    ..brevis IOEB 9809 tdc and aguA1 genes, during wine fermentation and to evaluate the effect of substrate availability and pH on tdc and aguA1 expression, as well as on biogenic amine production and L. brevis viability...
  5. Melgarejo E, Urdiales J, Sanchez Jimenez F, Medina M. Targeting polyamines and biogenic amines by green tea epigallocatechin-3-gallate. Amino Acids. 2010;38:519-23 pubmed publisher
    b>Biogenic amines and polyamines are organic polycations derived from aromatic or cationic amino acids...
  6. Ringstad N, Abe N, Horvitz H. Ligand-gated chloride channels are receptors for biogenic amines in C. elegans. Science. 2009;325:96-100 pubmed publisher
    b>Biogenic amines such as serotonin and dopamine are intercellular signaling molecules that function widely as neurotransmitters and neuromodulators...
  7. Al Bulushi I, Poole S, Deeth H, Dykes G. Biogenic amines in fish: roles in intoxication, spoilage, and nitrosamine formation--a review. Crit Rev Food Sci Nutr. 2009;49:369-77 pubmed publisher
    b>Biogenic amines are non-volatile amines formed by decarboxylation of amino acids...
  8. Coloretti F, Chiavari C, Armaforte E, Carri S, Castagnetti G. Combined use of starter cultures and preservatives to control production of biogenic amines and improve sensorial profile in low-acid salami. J Agric Food Chem. 2008;56:11238-44 pubmed publisher
    ..The accumulation of biogenic amines, especially putrescine, cadaverine, tryptamine, and tyramine, in salami ready for consumption (60 days of ..
  9. Chen Y, Hung Y, Yang E. Biogenic amine levels change in the brains of stressed honeybees. Arch Insect Biochem Physiol. 2008;68:241-50 pubmed publisher
    ..The serotonin (5-HT) levels under these stress treatments were not changed...

More Information

Publications62

  1. Babusyte A, Kotthoff M, Fiedler J, Krautwurst D. Biogenic amines activate blood leukocytes via trace amine-associated receptors TAAR1 and TAAR2. J Leukoc Biol. 2013;93:387-94 pubmed publisher
    Certain biogenic amines, such as 2-PEA, TYR, or T1AM, modulate blood pressure, cardiac function, brain monoaminergic systems, and olfaction-guided behavior by specifically interacting with members of a group of rhodopsin-like receptors, ..
  2. Konakovsky V, Focke M, Hoffmann Sommergruber K, Schmid R, Scheiner O, Moser P, et al. Levels of histamine and other biogenic amines in high-quality red wines. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011;28:408-16 pubmed publisher
    b>Biogenic amines in wine may impair sensory wine quality and cause adverse health effects in susceptible individuals...
  3. Yamane T, Miyatake T. Reduced female mating receptivity and activation of oviposition in two Callosobruchus species due to injection of biogenic amines. J Insect Physiol. 2010;56:271-6 pubmed publisher
    ..In the present study, we investigated the effects of biogenic amines into the abdomens of females of two Callosobruchus species, Callosobruchus chinensis and Callosobruchus ..
  4. Mayer H, Fiechter G, Fischer E. A new ultra-pressure liquid chromatography method for the determination of biogenic amines in cheese. J Chromatogr A. 2010;1217:3251-7 pubmed publisher
    A fast and reliable ultra-performance liquid chromatography (UPLC) method for the determination of biogenic amines (ethanolamine, methylamine, agmatine, histamine, dimethylamine, ethylamine, octopamine, pyrrolidine, dopamine, ..
  5. Prester L, Macan J, Varnai V, Orct T, Vukusic J, Kipcic D. Endotoxin and biogenic amine levels in Atlantic mackerel (Scomber scombrus), sardine (Sardina pilchardus) and Mediterranean hake (Merluccius merluccius) stored at 22 degrees C. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009;26:355-62 pubmed publisher
    ..On the other hand, high endotoxin levels in hake, after 24 h, were associated with the low histamine and putrescine content (40-60 mg kg(-1))...
  6. Moreno Arribas M, Polo M. Occurrence of lactic acid bacteria and biogenic amines in biologically aged wines. Food Microbiol. 2008;25:875-81 pubmed publisher
    ..In this study, lactic acid bacteria microbiota and the presence of biogenic amines were investigated throughout the manufacture and biological aging of 36 samples of sherry wines...
  7. Simo C, Moreno Arribas M, Cifuentes A. Ion-trap versus time-of-flight mass spectrometry coupled to capillary electrophoresis to analyze biogenic amines in wine. J Chromatogr A. 2008;1195:150-6 pubmed publisher
    ..CE-IT-MS) and capillary electrophoresis-time-of-flight mass spectrometry (CE-TOF-MS), applied to analyze biogenic amines in wine samples are investigated...
  8. Vashchenko G, Bleackley M, Griffiths T, MacGillivray R. Oxidation of organic and biogenic amines by recombinant human hephaestin expressed in Pichia pastoris. Arch Biochem Biophys. 2011;514:50-6 pubmed publisher
    ..to oxidize a wide range of organic compounds including a group of physiologically relevant substrates (biogenic amines). To study oxidation of organic substrates, the human hephaestin ectodomain was expressed in Pichia pastoris...
  9. Tameem A, Saad B, Makahleh A, Salhin A, Saleh M. A 4-hydroxy-N'-[(E)-(2-hydroxyphenyl)methylidene]benzohydrazide-based sorbent material for the extraction-HPLC determination of biogenic amines in food samples. Talanta. 2010;82:1385-91 pubmed publisher
    ..The capability of the sorbent material for the extraction of seven biogenic amines (BAs), i.e...
  10. Vander Meer R, Preston C, Hefetz A. Queen regulates biogenic amine level and nestmate recognition in workers of the fire ant, Solenopsis invicta. Naturwissenschaften. 2008;95:1155-8 pubmed publisher
    ..This is the first demonstration of a link between the presence of the colony queen, a worker biogenic amine, and conspecific nestmate recognition, a powerful expression of colony cohesion and territoriality...
  11. Arrieta M, Prats Moya M. Free amino acids and biogenic amines in Alicante Monastrell wines. Food Chem. 2012;135:1511-9 pubmed publisher
    The simultaneous determination of 17 free amino acids and 8 biogenic amines in Alicante Monastrell wines was investigated for the first time...
  12. Hardeland R, Tan D, Reiter R. Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines. J Pineal Res. 2009;47:109-26 pubmed publisher
    Kynuramines represent their own class of biogenic amines. They are formed either by decarboxylation of kynurenines or pyrrole ring cleavage of indoleamines...
  13. Basheer C, Wong W, Makahleh A, Tameem A, Salhin A, Saad B, et al. Hydrazone-based ligands for micro-solid phase extraction-high performance liquid chromatographic determination of biogenic amines in orange juice. J Chromatogr A. 2011;1218:4332-9 pubmed publisher
    ..trapped in a silica sol-gel matrix, and were subsequently used in the micro-solid phase extraction (?-SPE) of biogenic amines (BAs). The BAs investigated were tryptamine, phenylethylamine, putrescine, histamine, tyramine and spermidine...
  14. Ribeiro P, Gupta V, El Sakkary N. Biogenic amines and the control of neuromuscular signaling in schistosomes. Invert Neurosci. 2012;12:13-28 pubmed publisher
    b>Biogenic amines are small cationic monoamines that function broadly as neurotransmitters and/or neuromodulators in every animal phylum...
  15. Ladero V, Coton M, Fernandez M, Buron N, Martín M, Guichard H, et al. Biogenic amines content in Spanish and French natural ciders: application of qPCR for quantitative detection of biogenic amine-producers. Food Microbiol. 2011;28:554-61 pubmed publisher
    b>Biogenic amines (BA) are low molecular weight nitrogenous bases commonly found in fermented foods and beverages and their consumption can induce undesirable reactions...
  16. Linares D, Martín M, Ladero V, Alvarez M, Fernandez M. Biogenic amines in dairy products. Crit Rev Food Sci Nutr. 2011;51:691-703 pubmed publisher
    b>Biogenic amines (BA) are organic, basic, nitrogenous compounds with biological activity, mainly formed by the decarboxylation of amino acids...
  17. García Ruiz A, González Rompinelli E, Bartolome B, Moreno Arribas M. Potential of wine-associated lactic acid bacteria to degrade biogenic amines. Int J Food Microbiol. 2011;148:115-20 pubmed publisher
    Some lactic acid bacteria (LAB) isolated from fermented foods have been proven to degrade biogenic amines through the production of amine oxidase enzymes...
  18. Facchini M, Decesari S, Rinaldi M, Carbone C, Finessi E, Mircea M, et al. Important source of marine secondary organic aerosol from biogenic amines. Environ Sci Technol. 2008;42:9116-21 pubmed
  19. Kao Y, Liu K, Huang M, Chiu T, Chang H. Analysis of amino acids and biogenic amines in breast cancer cells by capillary electrophoresis using polymer solutions containing sodium dodecyl sulfate. J Chromatogr A. 2010;1217:582-7 pubmed publisher
    ..The concentrations of Tau and Gln in the MCF-7 cells were different than those in the H184B5F5/M10 cells, respectively. Our results show the potential of this approach for cancer study...
  20. Gosetti F, Mazzucco E, Gennaro M, Marengo E. Simultaneous determination of sixteen underivatized biogenic amines in human urine by HPLC-MS/MS. Anal Bioanal Chem. 2013;405:907-16 pubmed publisher
    The broad group of biogenic amines includes polyamines and catecholamines, whose presence in human tissues and biological fluids can give important diagnostic information and act as marker of many pathologies...
  21. Huisman H, Wynveen P, Nichkova M, Kellermann G. Novel ELISAs for screening of the biogenic amines GABA, glycine, beta-phenylethylamine, agmatine, and taurine using one derivatization procedure of whole urine samples. Anal Chem. 2010;82:6526-33 pubmed publisher
    ..GABA, glycine and agmatine and neuromodulators beta-phenylethylamine (beta-PEA) and taurine are important biogenic amines of the sympathetic and parasympathetic nervous systems in the body...
  22. Zaman M, Abu Bakar F, Jinap S, Bakar J. Novel starter cultures to inhibit biogenic amines accumulation during fish sauce fermentation. Int J Food Microbiol. 2011;145:84-91 pubmed publisher
    Bacteria with amine oxidase activity have become a particular interest to reduce biogenic amines concentration in food products such as meat and fish sausages...
  23. Kelly M, Blaise A, Larroque M. Rapid automated high performance liquid chromatography method for simultaneous determination of amino acids and biogenic amines in wine, fruit and honey. J Chromatogr A. 2010;1217:7385-92 pubmed publisher
    This paper reports a new, simple, rapid and economical method for routine determination of 24 amino acids and biogenic amines in grapes and wine...
  24. Min J, Lee S, Jang A, Jo C, Lee M. Control of microorganisms and reduction of biogenic amines in chicken breast and thigh by irradiation and organic acids. Poult Sci. 2007;86:2034-41 pubmed
    ..treatment of raw chicken breast and thigh meat to control inoculated microorganisms and the production of biogenic amines (BA) was studied...
  25. Nannelli F, Claisse O, Gindreau E, de Revel G, Lonvaud Funel A, Lucas P. Determination of lactic acid bacteria producing biogenic amines in wine by quantitative PCR methods. Lett Appl Microbiol. 2008;47:594-9 pubmed publisher
    To develop rapid methods allowing enumeration of lactic acid bacteria producing biogenic amines in wines and to analyse wine samples by the methods.
  26. Tekes K, Gyenge M, Folyovich A, Csaba G. Influence of neonatal vitamin A or vitamin D treatment on the concentration of biogenic amines and their metabolites in the adult rat brain. Horm Metab Res. 2009;41:277-80 pubmed publisher
    ..As prophylactic treatment with these vitamins is frequent in the perinatal period, the imprinting effect of vitamin A and vitamin D must be taken into consideration...
  27. Landete J, Arena M, Pardo I, Manca de Nadra M, Ferrer S. Comparative survey of putrescine production from agmatine deamination in different bacteria. Food Microbiol. 2008;25:882-7 pubmed publisher
    ..The effect of different biogenic amines, organic acids, cofactors, amino acids and sugars on putrescine production was evaluated...
  28. Farooqui T. A potential link among biogenic amines-based pesticides, learning and memory, and colony collapse disorder: a unique hypothesis. Neurochem Int. 2013;62:122-36 pubmed publisher
    ..Causes of CCD are not known. In this overview, I discuss CCD, biogenic amines-based-pesticides (neonicotinoids and formamidines), and their disruptive effects on biogenic amine signaling ..
  29. Tamang J, Tamang B, Schillinger U, Guigas C, Holzapfel W. Functional properties of lactic acid bacteria isolated from ethnic fermented vegetables of the Himalayas. Int J Food Microbiol. 2009;135:28-33 pubmed publisher
    ..capacity, enzymatic activities, degradation of antinutritive factors and oligosaccharides, production of biogenic amines, hydrophobicity and adherence to mucus secreting HT29 MTX cells...
  30. Naila A, Flint S, Fletcher G, Bremer P, Meerdink G. Control of biogenic amines in food--existing and emerging approaches. J Food Sci. 2010;75:R139-50 pubmed publisher
    b>Biogenic amines have been reported in a variety of foods, such as fish, meat, cheese, vegetables, and wines. They are described as low molecular weight organic bases with aliphatic, aromatic, and heterocyclic structures...
  31. Tekes K, Gyenge M, Sotonyi P, Csaba G. Effect of neonatal nociceptin or nocistatin imprinting on the brain concentration of biogenic amines and their metabolites. Brain Dev. 2009;31:282-7 pubmed publisher
  32. Curiel J, Ruiz Capillas C, de las Rivas B, Carrascosa A, Jimenez Colmenero F, Munoz R. Production of biogenic amines by lactic acid bacteria and enterobacteria isolated from fresh pork sausages packaged in different atmospheres and kept under refrigeration. Meat Sci. 2011;88:368-73 pubmed publisher
    ..The presence of biogenic amines in decarboxylase broth was confirmed by ion-exchange chromatography and by the presence of the corresponding ..
  33. Prester L. Biogenic amines in fish, fish products and shellfish: a review. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011;28:1547-60 pubmed publisher
    ..and certain cancer may be offset by fish decomposition and the formation of chemical contaminants such as biogenic amines. There are several toxicological effects of biogenic amines on humans, especially histamine...
  34. Obara Y, Fukano Y, Watanabe K, Ozawa G, Sasaki K. Serotonin-induced mate rejection in the female cabbage butterfly, Pieris rapae crucivora. Naturwissenschaften. 2011;98:989-93 pubmed publisher
    ..This study tested whether the biogenic amines, serotonin (5HT), dopamine (DA), and octopamine (OA), were responsible for this change in behavior...
  35. Fang H, Vickrey T, Venton B. Analysis of biogenic amines in a single Drosophila larva brain by capillary electrophoresis with fast-scan cyclic voltammetry detection. Anal Chem. 2011;83:2258-64 pubmed publisher
    ..These results show that CE-FSCV is useful for monitoring the impact of genetic and pharmacological manipulations on the content of multiple neurotransmitters in a CNS from a Drosophila larva...
  36. Shukla S, Park H, Kim J, Kim M. Determination of biogenic amines in Korean traditional fermented soybean paste (Doenjang). Food Chem Toxicol. 2010;48:1191-5 pubmed publisher
    b>Biogenic amines, produced by bacterial decarboxylation of amino acids, have been associated with toxicological symptoms in food products...
  37. Yongsawatdigul J, Rodtong S, Raksakulthai N. Acceleration of Thai fish sauce fermentation using proteinases and bacterial starter cultures. J Food Sci. 2007;72:M382-90 pubmed
    ..Staphylococcus sp. SK1-1-5 is a potential strain that can be applied to produce fish sauce with overall sensory characteristics of traditional fish sauce in shorter time...
  38. Spano G, Russo P, Lonvaud Funel A, Lucas P, Alexandre H, Grandvalet C, et al. Biogenic amines in fermented foods. Eur J Clin Nutr. 2010;64 Suppl 3:S95-100 pubmed publisher
    ..Some species of LAB, however, can produce biogenic amines (BAs). BAs are organic, basic, nitrogenous compounds, mainly formed through decarboxylation of amino acids...
  39. Bhutani M, Bishnoi M, Kulkarni S. Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes. Pharmacol Biochem Behav. 2009;92:39-43 pubmed publisher
    ..This study provided a scientific rationale for the use of curcumin and its co-administration with piperine in the treatment of depressive disorders...
  40. Emborg J, Laursen B, Dalgaard P. Significant histamine formation in tuna (Thunnus albacares) at 2 degrees C--effect of vacuum- and modified atmosphere-packaging on psychrotolerant bacteria. Int J Food Microbiol. 2005;101:263-79 pubmed
    ..The objective was to evaluate microbial formation of histamine and biogenic amines in chilled fresh tuna from the Indian Ocean and stored either vacuum-packed (VP) or modified atmosphere-..
  41. Singewald N, Philippu A. Involvement of biogenic amines and amino acids in the central regulation of cardiovascular homeostasis. Trends Pharmacol Sci. 1996;17:356-63 pubmed
    b>Biogenic amines and amino acids have been implicated in central cardiovascular homeostasis. Initially, drugs were injected into the brain and their effects on blood pressure were investigated...
  42. Marks H, Anderson C. Rapid determination and confirmation of biogenic amines in tuna loin by gas chromatography/mass spectrometry using ethylchloroformate derivative. J AOAC Int. 2006;89:1591-9 pubmed
    ..GC/MS) method is described for the easy rapid determination and simultaneous confirmation of the biogenic amines putrescine (PUT), cadaverine (CAD), histamine (HTA), and spermidine (SPD) in fresh frozen tuna loin...
  43. Hernandez Orte P, Peña Gallego A, Ibarz M, Cacho J, Ferreira V. Determination of the biogenic amines in musts and wines before and after malolactic fermentation using 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate as the derivatizing agent. J Chromatogr A. 2006;1129:160-4 pubmed
    ..and sensitive high-performance liquid chromatographic (HPLC) method is reported for the determination of four biogenic amines in red and white wine samples...
  44. Hanczko R, Koros A, Toth F, Molnár Perl I. Behavior and characteristics of biogenic amines, ornithine and lysine derivatized with the o-phthalaldehyde-ethanethiol-fluorenylmethyl chloroformate reagent. J Chromatogr A. 2005;1087:210-22 pubmed
    ..Average reproducibility of quantitations, characterized with the relative standard deviation percentages of fluorescence intensities and UV responses, in order of listing, proved to be 2.1% and 2.1%, respectively...
  45. Héberger K, Csomós E, Simon Sarkadi L. Principal component and linear discriminant analyses of free amino acids and biogenic amines in hungarian wines. J Agric Food Chem. 2003;51:8055-60 pubmed
    ..Determination of free amino acids and biogenic amines was accomplished by ion-exchange chromatography...
  46. Suzzi G, Gardini F. Biogenic amines in dry fermented sausages: a review. Int J Food Microbiol. 2003;88:41-54 pubmed
    b>Biogenic amines are compounds commonly present in living organisms in which they are responsible for many essential functions...
  47. Loukou Z, Zotou A. Determination of biogenic amines as dansyl derivatives in alcoholic beverages by high-performance liquid chromatography with fluorimetric detection and characterization of the dansylated amines by liquid chromatography-atmospheric pressure chemical i. J Chromatogr A. 2003;996:103-13 pubmed
    A sensitive high-performance liquid chromatographic method for the simultaneous determination of 11 biogenic amines has been developed...
  48. Medina M, Urdiales J, Rodriguez Caso C, Ramirez F, Sanchez Jimenez F. Biogenic amines and polyamines: similar biochemistry for different physiological missions and biomedical applications. Crit Rev Biochem Mol Biol. 2003;38:23-59 pubmed
    b>Biogenic amines are organic polycations derived from aromatic or cationic amino acids. All of them have one or more positive charges and a hydrophobic skeleton...
  49. Connil N, Prevost H, Dousset X. Production of biogenic amines and divercin V41 in cold smoked salmon inoculated with Carnobacterium divergens V41, and specific detection of this strain by multiplex-PCR. J Appl Microbiol. 2002;92:611-7 pubmed
    The objective of this study was to determine the technological behaviour (implantation and biogenic amines production) of Carnobacterium divergens V41, an anti-Listeria bacteriocin producer (divercin V41), after inoculation in cold ..
  50. Sanchez C, Hyttel J. Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell Mol Neurobiol. 1999;19:467-89 pubmed
    1. The present survey compares the effects of antidepressants and their principal metabolites on reuptake of biogenic amines and on receptor binding...
  51. Monastirioti M. Biogenic amine systems in the fruit fly Drosophila melanogaster. Microsc Res Tech. 1999;45:106-21 pubmed
    b>Biogenic amines are important neuroactive molecules of the central nervous system (CNS) of several insect species...
  52. Schulz D, Robinson G. Octopamine influences division of labor in honey bee colonies. J Comp Physiol A. 2001;187:53-61 pubmed
    ..These results demonstrate that octopamine influences division of labor in honey bee colonies. We speculate that octopamine is acting in this context as a neuromodulator...
  53. Marino M, Maifreni M, Moret S, Rondinini G. The capacity of Enterobacteriaceae species to produce biogenic amines in cheese. Lett Appl Microbiol. 2000;31:169-73 pubmed
    The amino acid decarboxylating activity and production of biogenic amines by 104 cheese-associated Enterobacteriaceae species (58 Enterobacter, 18 Serratia, eight Escherichia, seven Hafnia, six Arizona, four Citrobacter and three ..