benzylamines

Summary

Summary: Toluenes in which one hydrogen of the methyl group is substituted by an amino group. Permitted are any substituents on the benzene ring or the amino group.

Top Publications

  1. Zhao Z, Fefelova N, Shanmugam M, Bishara P, Babu G, Xie L. Angiotensin II induces afterdepolarizations via reactive oxygen species and calmodulin kinase II signaling. J Mol Cell Cardiol. 2011;50:128-36 pubmed publisher
    ..These results provide evidence supporting a link between renin-angiotensin system and cardiac arrhythmias...
  2. Liu N, Ruan Y, Denegri M, Bachetti T, Li Y, Colombi B, et al. Calmodulin kinase II inhibition prevents arrhythmias in RyR2(R4496C+/-) mice with catecholaminergic polymorphic ventricular tachycardia. J Mol Cell Cardiol. 2011;50:214-22 pubmed publisher
    ..CaMKII inhibition may therefore represent a novel therapeutic target for patients with CPVT...
  3. Endo Y, Bäckvall J. Biomimetic oxidative coupling of benzylamines and 2-aminophenols: synthesis of benzoxazoles. Chemistry. 2012;18:13609-13 pubmed publisher
    ..This biomimetic oxidation proceeds smoothly under mild conditions and the protocol can also be used for preparing benzimidazoles and benzothiazoles...
  4. Opazo P, Labrecque S, Tigaret C, Frouin A, Wiseman P, De Koninck P, et al. CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin. Neuron. 2010;67:239-52 pubmed publisher
    ..Thus, NMDA-dependent Ca(2+) influx in the post-synapse triggers a CaMKII- and Stargazin-dependent decrease in AMPAR diffusional exchange at synapses that controls synaptic function...
  5. Meyer zu Horste G, Mausberg A, Korth C, Stuve O, Kieseier B. Quinpramine--a promising compound for treating immune-mediated demyelination of the nervous system. Drug News Perspect. 2010;23:287-94 pubmed publisher
    ..This article summarizes available treatment options in MS and explains why the candidate compound quinpramine may transfer from bench to bedside in the near future...
  6. Ashpole N, Hudmon A. Excitotoxic neuroprotection and vulnerability with CaMKII inhibition. Mol Cell Neurosci. 2011;46:720-30 pubmed publisher
  7. Kushikata T, Yoshida H, Kudo M, Kudo T, Hirota K. Role of coerulean noradrenergic neurones in general anaesthesia in rats. Br J Anaesth. 2011;107:924-9 pubmed publisher
    ..We hypothesized that these neurones are also involved in both activation of the ?-aminobutyric acid type A (GABA(A)) receptor and inhibition of N-methyl-d-aspartate (NMDA) receptor-mediated anaesthesia...
  8. Sontag T, Hauser J, Tucha O, Lange K. Effects of DSP4 and methylphenidate on spatial memory performance in rats. Atten Defic Hyperact Disord. 2011;3:351-8 pubmed publisher
    ..It is suggested that a reduction of noradrenaline and an increase of dopamine induce ADHD-related deficits and that the depletion of noradrenaline is not sufficient for an appropriate rat model of ADHD...
  9. Gururaj H, Padma M, Giridhar P, Ravishankar G. Functional validation of Capsicum frutescens aminotransferase gene involved in vanillylamine biosynthesis using Agrobacterium mediated genetic transformation studies in Nicotiana tabacum and Capsicum frutescens calli cultures. Plant Sci. 2012;195:96-105 pubmed publisher
    ..The result is a clear evidence of involvement of the reported putative aminotransferase responsible for vanillylamine biosynthesis in capsaicinoid biosynthesis pathway, confirming the gene function through functional validation...

More Information

Publications62

  1. Donkin J, Stukas S, Hirsch Reinshagen V, Namjoshi D, Wilkinson A, May S, et al. ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice. J Biol Chem. 2010;285:34144-54 pubmed publisher
    ..These results suggest that ABCA1 contributes to several beneficial effects of the LXR agonist GW3965 in APP/PS1 mice...
  2. Spyridon M, Moraes L, Jones C, Sage T, Sasikumar P, Bucci G, et al. LXR as a novel antithrombotic target. Blood. 2011;117:5751-61 pubmed publisher
    ..The athero-protective effects of GW3965, together with its novel antiplatelet/thrombotic effects, indicate LXR as a potential target for prevention of athero-thrombotic disease...
  3. Dresser M, Kang D, Staehr P, Gidwani S, Guo C, Mulhall J, et al. Pharmacokinetics of dapoxetine, a new treatment for premature ejaculation: Impact of age and effects of a high-fat meal. J Clin Pharmacol. 2006;46:1023-9 pubmed
    ..Thus, age or consumption of a high-fat meal has only a modest impact on dapoxetine pharmacokinetics in healthy men...
  4. Sironi L, Mitro N, Cimino M, Gelosa P, Guerrini U, Tremoli E, et al. Treatment with LXR agonists after focal cerebral ischemia prevents brain damage. FEBS Lett. 2008;582:3396-400 pubmed publisher
    ..Neuroprotection was associated with suppression of neuroinflammation...
  5. Middleton D, Andrews M, Glossop P, Gymer G, Hepworth D, Jessiman A, et al. Designing rapid onset selective serotonin re-uptake inhibitors. Part 3: Site-directed metabolism as a strategy to avoid active circulating metabolites: structure-activity relationships of (thioalkyl)phenoxy benzylamines. Bioorg Med Chem Lett. 2008;18:5303-6 pubmed publisher
    ..Overall, sulfonamide 20 was found to possess the best balance of target pharmacology, pharmacokinetics and metabolism profile...
  6. Kan W, Hsu J, Schwacha M, Choudhry M, Raju R, Bland K, et al. Selective inhibition of iNOS attenuates trauma-hemorrhage/resuscitation-induced hepatic injury. J Appl Physiol (1985). 2008;105:1076-82 pubmed publisher
    ..These results indicate that increased expression of iNOS following trauma-hemorrhage plays an important role in the induction of hepatic damage under such conditions...
  7. Lundberg J, Christophersen J, Petersen K, Loft H, Halldin C, Farde L. PET measurement of serotonin transporter occupancy: a comparison of escitalopram and citalopram. Int J Neuropsychopharmacol. 2007;10:777-85 pubmed
    ..05). The small but significant difference in occupancy and K(i),(app) found between R,S-citalopram and S-citalopram suggests that not only S-citalopram but also R-citalopram to some degree occupies the 5-HTT in the human brain in vivo...
  8. Buvat J, Tesfaye F, Rothman M, Rivas D, Giuliano F. Dapoxetine for the treatment of premature ejaculation: results from a randomized, double-blind, placebo-controlled phase 3 trial in 22 countries. Eur Urol. 2009;55:957-67 pubmed publisher
    ..Dapoxetine is being developed for the on-demand treatment of premature ejaculation (PE). Previous clinical trials have demonstrated its safety and efficacy...
  9. Chen Y, Yang C, Wang Z. Ca2+/calmodulin-dependent protein kinase II alpha is required for the initiation and maintenance of opioid-induced hyperalgesia. J Neurosci. 2010;30:38-46 pubmed publisher
    ..These data implicate, for the first time, an essential role of CaMKIIalpha as a cellular mechanism leading to and maintaining opioid-induced hyperalgesia...
  10. Schätzle S, Höhne M, Redestad E, Robins K, Bornscheuer U. Rapid and sensitive kinetic assay for characterization of omega-transaminases. Anal Chem. 2009;81:8244-8 pubmed publisher
    ..This method was used for the characterization of a novel omega-TA cloned from Rhodobacter sphaeroides, and the data obtained were in excellent accordance with a standard capillary electrophoresis assay...
  11. Chen Y, Luo F, Yang C, Kirkmire C, Wang Z. Acute inhibition of Ca2+/calmodulin-dependent protein kinase II reverses experimental neuropathic pain in mice. J Pharmacol Exp Ther. 2009;330:650-9 pubmed publisher
    ..In conclusion, our findings support a critical role of CaMKII in neuropathic pain. Blocking CaMKII or CaMKII-mediated signaling may offer a novel therapeutic target for the treatment of neuropathic pain...
  12. El Mas M, Fan M, Abdel Rahman A. Endotoxemia-mediated induction of cardiac inducible nitric-oxide synthase expression accounts for the hypotensive effect of ethanol in female rats. J Pharmacol Exp Ther. 2008;324:368-75 pubmed
    ..These findings yield insight into the mechanistic role of endotoxin-myocardial iNOS signaling in the cardiodepressant action of ethanol, which accounts for its hypotensive effect in conscious female rats...
  13. Modi N, Nath R, Staehr P, Gupta S, Aquilina J, Rivas D. Pharmacokinetic, pharmacodynamic, and electrocardiographic effects of dapoxetine and moxifloxacin compared with placebo in healthy adult male subjects. J Clin Pharmacol. 2009;49:634-42 pubmed publisher
    ..Adverse events are generally mild in severity; nausea is the most common. The results demonstrate that dapoxetine does not have electrocardiographic effects at doses of 60, 120, and 240 mg...
  14. Terentyev D, Belevych A, Terentyeva R, Martin M, Malana G, Kuhn D, et al. miR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2. Circ Res. 2009;104:514-21 pubmed publisher
    ..We conclude that miR-1 enhances cardiac excitation-contraction coupling by selectively increasing phosphorylation of the L-type and RyR2 channels via disrupting localization of PP2A activity to these channels...
  15. Morales J, Ballesteros I, Deniz J, Hurtado O, Vivancos J, Nombela F, et al. Activation of liver X receptors promotes neuroprotection and reduces brain inflammation in experimental stroke. Circulation. 2008;118:1450-9 pubmed publisher
    ..These beneficial actions, however, have not been illustrated in other models of acute injury such as stroke in which inflammation is an important pathophysiological feature...
  16. Khoo M, Li J, Singh M, Yang Y, Kannankeril P, Wu Y, et al. Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy. Circulation. 2006;114:1352-9 pubmed
  17. Curran J, Hinton M, Rios E, Bers D, Shannon T. Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase. Circ Res. 2007;100:391-8 pubmed
    ..The results suggest that beta-AR stimulation enhances diastolic SR Ca leak in a manner that is (1) CaMKII dependent, (2) not protein kinase A dependent, and 3) not dependent on bulk [Ca](i)...
  18. Lundberg J, Borg J, Halldin C, Farde L. A PET study on regional coexpression of 5-HT1A receptors and 5-HTT in the human brain. Psychopharmacology (Berl). 2007;195:425-33 pubmed
    ..Several lines of evidence suggest inter-dependency between the serotonin transporter (5-HTT) and the 5HT1A receptor, two recognised targets for the treatment of anxiety and depression...
  19. Bortel A, Nowak P, Brus R. Neonatal DSP-4 treatment modifies GABAergic neurotransmission in the prefrontal cortex of adult rats. Neurotox Res. 2008;13:247-52 pubmed
    ..These findings indicate that neonatal DSP-4 treatment increases GABAergic neurotransmission in the PFC of rats in adulthood, perhaps by decreasing reactivity of central GABA(A) receptors...
  20. Birrell M, De Alba J, Catley M, Hardaker E, Wong S, Collins M, et al. Liver X receptor agonists increase airway reactivity in a model of asthma via increasing airway smooth muscle growth. J Immunol. 2008;181:4265-71 pubmed
  21. Yu Z, Wang Z, Yang H. Calcium/calmodulin-dependent protein kinase II mediates cardioprotection of intermittent hypoxia against ischemic-reperfusion-induced cardiac dysfunction. Am J Physiol Heart Circ Physiol. 2009;297:H735-42 pubmed publisher
    ..These findings indicate that preservation of SR CaMKII activity plays an important role in the IHA hypoxia-induced cardioprotection against I/R injury via maintaining SR Ca(2+)-uptake activity...
  22. Sontag T, Hauser J, Kaunzinger I, Gerlach M, Tucha O, Lange K. Effects of the noradrenergic neurotoxin DSP4 on spatial memory in the rat. J Neural Transm (Vienna). 2008;115:299-303 pubmed
    ..The use of different doses of DSP4 to influence prefrontal functions and to understand the dysbalance of dopamine and noradrenaline in ADHD appears to be a promising approach...
  23. McMahon C, Kim S, Park N, Chang C, Rivas D, Tesfaye F, et al. Treatment of premature ejaculation in the Asia-Pacific region: results from a phase III double-blind, parallel-group study of dapoxetine. J Sex Med. 2010;7:256-68 pubmed publisher
    ..Dapoxetine is a short-acting selective serotonin reuptake inhibitor that was recently approved for the on-demand treatment of premature ejaculation (PE)...
  24. Thyssen A, Sharma O, Tianmei S, Aquilina J, Vandebosch A, Wang S, et al. Pharmacokinetics of dapoxetine hydrochloride in healthy Chinese, Japanese, and Caucasian men. J Clin Pharmacol. 2010;50:1450-60 pubmed publisher
    ..Dapoxetine was well tolerated by all 3 ethnic groups...
  25. Bortel A, Słomian L, Nitka D, Swierszcz M, Jaksz M, Adamus Sitkiewicz B, et al. Neonatal N-(-2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) treatment modifies the vulnerability to phenobarbital- and ethanol-evoked sedative-hypnotic effects in adult rats. Pharmacol Rep. 2008;60:331-8 pubmed
    ..These findings indicate that the noradrenergic system exerts a prominent influence on sedative-hypnotics acting via GABAergic systems in the brain without directly altering GABA levels in the brain...
  26. Shabsigh R, Patrick D, Rowland D, Bull S, Tesfaye F, Rothman M. Perceived control over ejaculation is central to treatment benefit in men with premature ejaculation: results from phase III trials with dapoxetine. BJU Int. 2008;102:824-8 pubmed publisher
  27. Vila Petroff M, Salas M, Said M, Valverde C, Sapia L, Portiansky E, et al. CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury. Cardiovasc Res. 2007;73:689-98 pubmed
    ..The goal of the present study is to investigate the role of CaMKII in irreversible ischemia and reperfusion (I/R) injury...
  28. Sag C, Wadsack D, Khabbazzadeh S, Abesser M, Grefe C, Neumann K, et al. Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure. Circ Heart Fail. 2009;2:664-75 pubmed publisher
    ..We hypothesized that CaMKII contributes to arrhythmias and underlying cellular events and that inhibition of CaMKII reduces cardiac arrhythmogenesis in vitro and in vivo...
  29. Lang Y, Kisaka H, Sugiyama R, Nomura K, Morita A, Watanabe T, et al. Functional loss of pAMT results in biosynthesis of capsinoids, capsaicinoid analogs, in Capsicum annuum cv. CH-19 Sweet. Plant J. 2009;59:953-61 pubmed publisher
    ..The dCAPS marker will be useful in selecting lines with capsinoid-containing fruits in pepper-breeding programs...
  30. Luo F, Yang C, Chen Y, Shukla P, Tang L, Wang L, et al. Reversal of chronic inflammatory pain by acute inhibition of Ca2+/calmodulin-dependent protein kinase II. J Pharmacol Exp Ther. 2008;325:267-75 pubmed publisher
    ..In conclusion, our findings support a critical role of CaMKII in inflammatory pain. Blocking CaMKII or CaMKII-mediated signaling may offer a novel therapeutic target for the treatment of chronic pain...
  31. Kaufman J, Rosen R, Mudumbi R, Tesfaye F, Hashmonay R, Rivas D. Treatment benefit of dapoxetine for premature ejaculation: results from a placebo-controlled phase III trial. BJU Int. 2009;103:651-8 pubmed publisher
    ..Although these factors are key elements of numerous sets of diagnostic criteria for PE, they have rarely been evaluated as outcome measures in clinical trials...
  32. Sharrock N, Gonzalez Della Valle A, Go G, Lyman S, Salvati E. Potent anticoagulants are associated with a higher all-cause mortality rate after hip and knee arthroplasty. Clin Orthop Relat Res. 2008;466:714-21 pubmed publisher
    ..4 and 0.52, respectively). Clinical pulmonary embolus occurs despite the use of anticoagulants. Group A anticoagulants were associated with the highest all-cause mortality of the three modalities studied...
  33. Said M, Becerra R, Palomeque J, Rinaldi G, Kaetzel M, Diaz Sylvester P, et al. Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II. Am J Physiol Heart Circ Physiol. 2008;295:H1669-83 pubmed publisher
    ..The results reveal that arrhythmias after acidosis are dependent on CaMKII activation and are associated with an increase in SR Ca(2+) load, which appears to be mainly due to the increase in PT-PLN...
  34. Jiang Q, Lee C, Mandrekar S, Wilkinson B, Cramer P, Zelcer N, et al. ApoE promotes the proteolytic degradation of Abeta. Neuron. 2008;58:681-93 pubmed publisher
    ..GW3965 treatment also reversed contextual memory deficits. These data demonstrate a mechanism through which ApoE facilitates the clearance of Abeta from the brain and suggest that LXR agonists may represent a novel therapy for AD...
  35. DAUGULIS O, Do H, Shabashov D. Palladium- and copper-catalyzed arylation of carbon-hydrogen bonds. Acc Chem Res. 2009;42:1074-86 pubmed publisher
    ..Using palladium acetate as the catalyst, we arylated anilides, benzamides, benzoic acids, benzylamines, and 2-substituted pyridine derivatives under nearly identical conditions...
  36. Pryor J, Althof S, Steidle C, Rosen R, Hellstrom W, Shabsigh R, et al. Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials. Lancet. 2006;368:929-37 pubmed
    ..No drugs are approved for treatment of premature ejaculation. Our aim was to determine the efficacy and tolerability of on-demand dapoxetine in patients with severe premature ejaculation...
  37. McMahon C. Dapoxetine for premature ejaculation. Expert Opin Pharmacother. 2010;11:1741-52 pubmed publisher
    ..Drug treatment of PE with an off-label antidepressant selective serotonin reuptake inhibitor (SSRI) drug is common. The lack of an approved drug and total reliance on off-label treatment represents a substantial unmet treatment need...
  38. Vest R, O Leary H, Coultrap S, Kindy M, Bayer K. Effective post-insult neuroprotection by a novel Ca(2+)/ calmodulin-dependent protein kinase II (CaMKII) inhibitor. J Biol Chem. 2010;285:20675-82 pubmed publisher
    ..Together, these data demonstrate that inhibition of autonomous CaMKII activity provides a promising therapeutic avenue for post-insult neuro-protection after stroke...
  39. Phelan C, Weaver J, Steger D, Joshi S, Maslany J, Collins J, et al. Selective partial agonism of liver X receptor alpha is related to differential corepressor recruitment. Mol Endocrinol. 2008;22:2241-9 pubmed publisher
    ..Thus, differential recruitment of NCoR is a major determinant of partial agonism and selective LXR modulation of target genes...
  40. Foster J, Carmines P, Pollock J. PP2B-dependent NO production in the medullary thick ascending limb during diabetes. Am J Physiol Renal Physiol. 2009;297:F471-80 pubmed publisher
    ..In conclusion, while NO bioavailability in mTALs is reduced during diabetes, free radical scavenging with tempol unmasks increased NO production that involves PP2B-dependent activation of NOS1 and NOS2...
  41. Kalinin S, Gavrilyuk V, Polak P, Vasser R, Zhao J, Heneka M, et al. Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease. Neurobiol Aging. 2007;28:1206-14 pubmed
    ..These findings suggest that noradrenergic innervation from LC are needed to maintain adequate Abeta clearance, and therefore that LC degeneration could contribute to AD pathogenesis...
  42. Kasturi G, Adler R. The extent of diagnosis and treatment of osteoporosis in a Veterans Affairs population undergoing vertebral augmentation. PM R. 2010;2:811-6 pubmed publisher
    ..To investigate whether patients with vertebral fracture who underwent an augmentation procedure had pre- or postaugmentation osteoporosis evaluation and treatment...
  43. Souza F, Gobbato N, Maciel R, Prado C, Martins M, Leick E, et al. Effects of corticosteroid, montelukast and iNOS inhibition on distal lung with chronic inflammation. Respir Physiol Neurobiol. 2013;185:435-45 pubmed publisher
    ..We evaluated the effects of anti-iNOS (1400W - W) associated with leukotriene antagonist (montelukast - M) or corticosteroid (dexamethasone - D) on distal lung of guinea pigs (GP) with chronic pulmonary inflammation...
  44. Marquet A, Kupas K, Johne A, Astruc B, Patat A, Krösser S, et al. The effect of safinamide, a novel drug for Parkinson's disease, on pressor response to oral tyramine: a randomized, double-blind, clinical trial. Clin Pharmacol Ther. 2012;92:450-7 pubmed publisher
    ..12; phenelzine, 9.98). This study confirms that safinamide is a highly selective monoamine oxidase-B inhibitor, even at supratherapeutic doses, and suggests that it can be administered without tyramine-related dietary restrictions...
  45. Wesson D, Borkowski A, Landreth G, Nixon R, Levy E, Wilson D. Sensory network dysfunction, behavioral impairments, and their reversibility in an Alzheimer's ?-amyloidosis mouse model. J Neurosci. 2011;31:15962-71 pubmed publisher
  46. Jin Y, Andresen M. GABA(B) restrains release from singly-evoked GABA terminals. Neuroscience. 2011;193:54-62 pubmed publisher
    ..The results suggest strong, surprisingly long-lasting, negative feedback by GABA(B) receptors within single GABA terminals that determine release probability even in isolated terminals...
  47. Delaville C, Navailles S, Benazzouz A. Effects of noradrenaline and serotonin depletions on the neuronal activity of globus pallidus and substantia nigra pars reticulata in experimental parkinsonism. Neuroscience. 2012;202:424-33 pubmed publisher
    ..Finally, our data suggest that, in addition to the primary role of DA in the control of basal ganglia activity, NA and 5-HT depletion also contribute to the dysregulation of the basal ganglia in PD by changes to neuronal firing patterns...
  48. Gou L, Zhang L, Yin C, Jia G, Yin X, Zhuang X, et al. Protective effect of L-citrulline against acute gastric mucosal lesions induced by ischemia-reperfusion in rats. Can J Physiol Pharmacol. 2011;89:317-27 pubmed publisher
  49. Feige A, Pinsky M, Hellstrom W. Dapoxetine for premature ejaculation. Clin Pharmacol Ther. 2011;89:125-8 pubmed publisher
    ..3 The lack of ejaculatory control is consistent among all clinical definitions of PE and is a highly sensitive predictor of the condition...
  50. Archer A, Venteclef N, Mode A, Pedrelli M, Gabbi C, Clement K, et al. Fasting-induced FGF21 is repressed by LXR activation via recruitment of an HDAC3 corepressor complex in mice. Mol Endocrinol. 2012;26:1980-90 pubmed publisher
    ..Our data clearly demonstrate that there is a cross talk between the LXR and FGF21 signaling pathways in the adaptive response to fasting...
  51. Giese M, Albrecht M, Bannwarth C, Raabe G, Valkonen A, Rissanen K. From attraction to repulsion: anion-? interactions between bromide and fluorinated phenyl groups. Chem Commun (Camb). 2011;47:8542-4 pubmed publisher
    ..Anion-? interactions in crystals of fluorobenzyl ammonium salts depend on the degree of fluorination at the aromatics...
  52. Kaurstad G, Alves M, Kemi O, Rolim N, Høydal M, Wisløff H, et al. Chronic CaMKII inhibition blunts the cardiac contractile response to exercise training. Eur J Appl Physiol. 2012;112:579-88 pubmed publisher
    ..Thus, the effect of chronic CaMKII inhibition is multifaceted and of a complex nature...
  53. Charrier C, Machado P, Tweedie Cullen R, Rutishauser D, Mansuy I, Triller A. A crosstalk between ?1 and ?3 integrins controls glycine receptor and gephyrin trafficking at synapses. Nat Neurosci. 2010;13:1388-95 pubmed publisher
    ..This provides a mechanism for maintaining or adjusting the steady state of postsynaptic molecule exchanges and the level of glycinergic inhibition in response to neuron- and glia-derived signals or extracellular matrix remodeling...