sulfisoxazole

Summary

Summary: A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.

Top Publications

  1. Syed H, Safa R, Chidlow G, Osborne N. Sulfisoxazole, an endothelin receptor antagonist, protects retinal neurones from insults of ischemia/reperfusion or lipopolysaccharide. Neurochem Int. 2006;48:708-17 pubmed
    ..In the present study the influence of the non-selective endothelin antagonist, sulfisoxazole on raised intraocular pressure-induced ischemia to the rat retina was investigated...
  2. Mondelli M, Bruné V, Borthagaray G, Ellena J, Nascimento O, Leite C, et al. New Ni(II)-sulfonamide complexes: synthesis, structural characterization and antibacterial properties. X-ray diffraction of [Ni(sulfisoxazole)2(H2O)4].2H2O and [Ni(sulfapyridine)2]. J Inorg Biochem. 2008;102:285-92 pubmed
    The synthesis, structural characterization, voltammetric experiments and antibacterial activity of [Ni(sulfisoxazole)(2)(H(2)O)(4)]...
  3. Zhao W, Sui Q, Mei X, Cheng X. Efficient elimination of sulfonamides by an anaerobic/anoxic/oxic-membrane bioreactor process: Performance and influence of redox condition. Sci Total Environ. 2018;633:668-676 pubmed publisher
    ..The results indicated that only sulfisoxazole could be removed under anaerobic condition...
  4. Markopoulou C, Malliou E, Koundourellis J. Chemometric and derivative methods as flexible spectrophotometric approaches for dissolution and assaying tests in multicomponent tablets. Farmaco. 2004;59:627-36 pubmed
    ..For SFZ, only 85% of the compound was dissolved after 60 min. In this study, the three spectrophotometric methods can be satisfactorily used for the quantitative analysis and for dissolution tests of multicomponent dosage forms. ..
  5. Lambert Zechovsky N, Mariani Kurkdjian P, Doit C, Bourgeois F, Bingen E. In-vitro bactericidal activity of four oral antibiotics against pathogens responsible for acute otitis media in children. J Hosp Infect. 1992;22 Suppl A:89-97 pubmed
    ..6 mg l-1 and 2.5 mg l-1/1.2 mg l-1), cefaclor (1 mg l-1), erythromycin (0.5 mg l-1) and erythromycin/sulfisoxazole (0.2/3 mg l-1). The inoculum was of 10(6) colony-forming units (cfu) ml-1...
  6. Rehman M, Yin X, Lepp D, Laing C, Ziebell K, Talbot G, et al. Genomic Analysis of Third Generation Cephalosporin Resistant Escherichia coli from Dairy Cow Manure. Vet Sci. 2017;4: pubmed publisher
    ..being amoxicillin-clavulanic acid-ampicillin-cefoxitin-ceftiofur-ceftriaxone-chloramphenicol-streptomycin-sulfisoxazole-tetracycline-trimethoprim-sulfamethoxazole...
  7. McClarty G, Fan H, Andersen A. Diversity in nucleotide acquisition by antigenically similar Chlamydia psittaci of avian origin. FEMS Microbiol Lett. 1993;108:325-31 pubmed
    ..The OMP1 genotyping results were confirmed by serotyping. ..
  8. Brann B, Stonestreet B, Oh W, Cashore W. The in vivo effect of bilirubin and sulfisoxazole on cerebral oxygen, glucose, and lactate metabolism in newborn piglets. Pediatr Res. 1987;22:135-40 pubmed
    ..piglets were divided into three groups and examined as follows: group 1 = control (C); group 2 = control with sulfisoxazole; and group 3 = experimental, given bilirubin with sulfisoxazole...
  9. Rožman M, Acuña V, Petrović M. Effects of chronic pollution and water flow intermittency on stream biofilms biodegradation capacity. Environ Pollut. 2018;233:1131-1137 pubmed publisher
    ..capacity while pollution was simulated by a mixture of four emerging contaminants (erythromycin, sulfisoxazole, diclofenac and imidacloprid in addition to venlafaxine) in environmentally relevant concentrations...

More Information

Publications62

  1. Cobbaut K, Houf K, Boyen F, Haesebrouck F, De Zutter L. Genotyping and antimicrobial resistance patterns of Escherichia coli O157 originating from cattle farms. Foodborne Pathog Dis. 2011;8:719-24 pubmed publisher
    ..All these 18 isolates were resistant toward streptomycin, and 16 of them also showed resistance toward sulfisoxazole. Six isolates were resistant to three or more antimicrobial agents.
  2. Gladys G, Claudia G, Marcela L. The effect of pH and triethanolamine on sulfisoxazole complexation with hydroxypropyl-beta-cyclodextrin. Eur J Pharm Sci. 2003;20:285-93 pubmed
    A novel complexation of sulfisoxazole with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was studied...
  3. Wang L, Henson E, McClarty G. Characterization of trimethoprim- and sulphisoxazole-resistant Chlamydia trachomatis. Mol Microbiol. 1994;14:271-81 pubmed
    ..L2Tri/5-FU was resistant to 5-fluorouracil because it had regained the capacity to take pyrimidine ribonucleotides from the host cell. ..
  4. Mandel E, Rockette H, Paradise J, Bluestone C, Nozza R. Comparative efficacy of erythromycin-sulfisoxazole, cefaclor, amoxicillin or placebo for otitis media with effusion in children. Pediatr Infect Dis J. 1991;10:899-906 pubmed
    We randomly assigned children with otitis media with effusion to receive either erythromycin-sulfisoxazole, cefaclor, amoxicillin or placebo for a 2-week period, primarily to determine whether either erythromycin-sulfisoxazole or ..
  5. Liu X, Steele J, Meng X. Usage, residue, and human health risk of antibiotics in Chinese aquaculture: A review. Environ Pollut. 2017;223:161-169 pubmed publisher
    ..For specific compound, ciprofloxacin, norfloxacin, and sulfisoxazole have the highest concentrations...
  6. Wang Y, Liu S, Li R, Huang Y, Chen C. Electro-catalytic degradation of sulfisoxazole by using graphene anode. J Environ Sci (China). 2016;43:54-60 pubmed publisher
    ..The electro-catalytic activity for degradation of sulfisoxazole (SIZ) was investigated by using prepared graphene or graphite anode...
  7. Curtis B, McFarland J, Wu G, Visentin G, Aster R. Antibodies in sulfonamide-induced immune thrombocytopenia recognize calcium-dependent epitopes on the glycoprotein IIb/IIIa complex. Blood. 1994;84:176-83 pubmed
    Drug-dependent IgG antibodies (DDAb) induced by sulfamethoxazole (SMX) and sulfisoxazole (SIX) were identified by flow cytometry in 15 patients who developed thrombocytopenia while taking one of these medications...
  8. Pholpramool C, Verawatnapakul V, Ruchirawat S, Lewin L. Mode of action of the antifertility sulphonamides: lack of effects on folate metabolism. Contraception. 1990;42:667-75 pubmed
    ..The results suggest that the antifertility activity of sulphanilamide, sulphapyridine and perhaps some other sulphonamides is not associated with the inhibition of folate metabolism. ..
  9. Atef M, Youssef S, Ramadan A, Issa M. Ruminal excretion of sulfadimethoxine and sulfadimethyloxazole in goats and their influence on some enzyme activities and renal clearances. Dtsch Tierarztl Wochenschr. 1990;97:203-6 pubmed
    ..v. injection, respectively. The creatinine clearance was significantly decreased after 4 hours following the i.v. administration of sulfadimethoxine and sulfadimethyloxazole in goats. ..
  10. Ojeniyi A. Direct transmission of Escherichia coli from poultry to humans. Epidemiol Infect. 1989;103:513-22 pubmed
    ..The MIC of the drugs against the avian and human E. coli isolates at the university and commercial poultry farms were similar. ..
  11. Blumenfeld H, Cha J, Cudkowicz M. Trimethoprim and sulfonamide-associated meningoencephalitis with MRI correlates. Neurology. 1996;46:556-8 pubmed
    ..These MRI findings are important because they may aid in early diagnosis of this condition in the appropriate clinical setting. In addition, the white matter abnormalities suggest an encephalitic component in addition to the meningitis. ..
  12. Poland G, Jorgensen C, Sarosi G. Nocardia asteroides pericarditis: report of a case and review of the literature. Mayo Clin Proc. 1990;65:819-24 pubmed
    ..Our case substantiates the excellent penetration of sulfisoxazole into the pericardial fluid, even with oral administration of the drug, and provides evidence in support of ..
  13. Begue P, Broussin B, Quinet B, Garabedian N, Sounthavong J, Riviere F. [Acute otitis media in children: a randomized and open clinical trial of the efficacy of 2 major antibiotics (erythromycin ethylsuccinate/acetyl sulfafurazole vs amoxicillin/clavulanic acid)]. Ann Pediatr (Paris). 1990;37:127-30 pubmed
    ..51 children wer assigned to amoxicillin + clavulanic acid (group I) and 60 to erythromycin-sulfisoxazole (group II). Mean age was respectively 24.7 months in group I and 23.4 months in group II...
  14. Kalish R, Laporte A, Wood J, Johnson K. Sulfonamide-reactive lymphocytes detected at very low frequency in the peripheral blood of patients with drug-induced eruptions. J Allergy Clin Immunol. 1994;94:465-72 pubmed
    ..The lymphocyte transformation test results to sulfamethoxazole, sulfisoxazole, and furosemide were found to be generally unreliable with a high rate of false-negative and false-positive ..
  15. Zhang P, Shen Z, Zhang C, Song L, Wang B, Shang J, et al. Surveillance of antimicrobial resistance among Escherichia coli from chicken and swine, China, 2008-2015. Vet Microbiol. 2017;203:49-55 pubmed publisher
    ..isolates showed high resistant rate (>80%) to several old drugs, including ampicillin, tetracycline and sulfisoxazole; (3) increasing resistance to colistin, florfenicol and ceftiofur was observed; (4) the E...
  16. Ge P, Yu H, Chen J, Qu J, Luo Y. Photolysis mechanism of sulfonamide moiety in five-membered sulfonamides: A DFT study. Chemosphere. 2018;197:569-575 pubmed publisher
    ..susceptible sulfonamide moiety of five-membered sulfonamide (SA) antibiotics, such as sulfamethoxazole, sulfisoxazole, sulfamethizole, and sulfathiazole...
  17. Yildiz Z, Celebioglu A, Uyar T. Polymer-free electrospun nanofibers from sulfobutyl ether7-beta-cyclodextrin (SBE7-?-CD) inclusion complex with sulfisoxazole: Fast-dissolving and enhanced water-solubility of sulfisoxazole. Int J Pharm. 2017;531:550-558 pubmed publisher
    ..Here, we prepared a highly concentrated aqueous solution of inclusion complex between sulfisoxazole and sulfobutyl ether7-beta-cyclodextrin (SBE7-?-CD, Captisol®), and then, ..
  18. El Chaar G, Mardy G, Wehlou K, Rubin L. Randomized, double blind comparison of brand and generic antibiotic suspensions: II. A study of taste and compliance in children. Pediatr Infect Dis J. 1996;15:18-22 pubmed
    ..Ten children in each of the cephalexin and erythromycin-sulfisoxazole groups did not report that the brand and generic formulations tasted differently...
  19. Karageorgou E, Manousi N, Samanidou V, Kabir A, Furton K. Fabric phase sorptive extraction for the fast isolation of sulfonamides residues from raw milk followed by high performance liquid chromatography with ultraviolet detection. Food Chem. 2016;196:428-36 pubmed publisher
    ..Decision limit (CCα) values were 116.5 μg kg(-1) for sulfamethazine, 114.4 μg kg(-1) for sulfisoxazole and 94...
  20. Albala D, Prien E, Galal H. Urolithiasis as a hazard of sulfonamide therapy. J Endourol. 1994;8:401-3 pubmed
    ..Early recognition of drug-related stones is essential to protect patients from recurrences, reduce the risk of renal complications, and avoid continuing ineffective therapeutic regimens. ..
  21. Dunlop R, McEwen S, Meek A, Clarke R, Friendship R, Black W, et al. Measurement of antimicrobial-resistant Escherichia coli in pig feces with a hydrophobic grid membrane filter interpreter system. Appl Environ Microbiol. 1998;64:366-9 pubmed
    ..filter technology was used to measure resistance among Escherichia coli in pig fecal samples to ampicillin, sulfisoxazole, and tetracycline. The method accurately measured resistance, with sensitivities ranging from 96.5 to 99...
  22. Bani Yaseen A. Solvatochromic and fluorescence behavior of sulfisoxazole. J Fluoresc. 2011;21:1061-7 pubmed publisher
    The Fluorescence spectroscopic and solvatochromic behavior of Sulfisoxazole, a sulfa drug with antimicrobial activities, in various pure solvents of different polarity and hydrogen bonding capability is reported...
  23. Eraslan G, Kibar M, Essiz D, Sahindokuyucu F, Liman B. Pharmacokinetic of sulfisoxazole in aqueous humor after topical and subconjunctival application in dogs. Pak J Biol Sci. 2007;10:4168-70 pubmed
    This study was undertaken to evaluate the ocular pharmacokinetic of sulfisoxazole. Male, 2-3 years old 10 mix breed dogs weighing 12-15 kg were used...
  24. Irollo B, Vu B, Dai D, Yonger J. Dissociation and association rate constants changes following bilirubin binding affinity decreases. Dev Pharmacol Ther. 1987;10:436-42 pubmed
    The effect of sulfisoxazole, sodium salicylate, sodium cholate, urea and dimethyl sulfoxide on the kinetics of the bilirubin to human serum albumin at 24 degrees C and pH 7.40 was investigated...
  25. Braun T, Kerson L, Eisenberg F. Nocardial brain abscesses in a pregnant woman. Rev Infect Dis. 1991;13:630-2 pubmed
    ..This case illustrates the difficulty in treating a nocardial infection of the brain during pregnancy as well as the importance of achieving adequate surgical drainage of the abscesses...
  26. Tewari D, Sandt C, Miller D, Jayarao B, M ikanatha N. Prevalence of Salmonella cerro in laboratory-based submissions of cattle and comparison with human infections in Pennsylvania, 2005-2010. Foodborne Pathog Dis. 2012;9:928-33 pubmed publisher
    ..2% of cattle isolates (n = 1/50) and 20% of human isolates (n = 2/10) showed resistance to tetracycline and sulfisoxazole. One human isolate showed additional resistance to ampicillin and gentamicin...
  27. Ward B, Andrews R, Gregory J, Lightfoot D. The use of sequential studies in a salmonellosis outbreak linked to continental custard cakes. Epidemiol Infect. 2002;129:287-93 pubmed
    ..00004). This report highlights the epidemiological value of using sequential study types, and persisting with the investigation of apparently sporadic food-borne outbreaks. ..
  28. Karwacki J, Shanks G, Limsomwong N, Singharaj P. Proguanil-sulphonamide for malaria prophylaxis. Trans R Soc Trop Med Hyg. 1990;84:55-7 pubmed
    ..Proguanil at an equivalent adult dose of 200 mg/d was combined with sulphafurazole (= sulfisoxazole) at 25 mg/kg/d or sulphamethoxazole at 25 and 10 mg/kg/d...
  29. Amini N, Vousooghi N, Hadjighassem M, Bakhtiyari M, Mousavi N, Safakheil H, et al. Efficacy of Human Adipose Tissue-Derived Stem Cells on Neonatal Bilirubin Encephalopathy in Rats. Neurotox Res. 2016;29:514-24 pubmed publisher
    ..in a preterm human, we injected phenylhydrazine in 7-day-old rats to induce haemolysis and then infused sulfisoxazole into the same rats at day 9 to block bilirubin binding sites in the albumin...
  30. Li Y, Wu X, Li Z, Zhong S, Wang W, Wang A, et al. Fabrication of CoFe2O4-graphene nanocomposite and its application in the magnetic solid phase extraction of sulfonamides from milk samples. Talanta. 2015;144:1279-86 pubmed publisher
    ..Five sulfonamides, including sulfamerazine, sulfamethizole, sulfadoxine, sulfamethoxazole and sulfisoxazole were used as model analytes to evaluate the enrichment properties of the prepared adsorbent in MSPE...
  31. Simon M. Treatment of acute sinusitis in childhood with ceftibuten. Clin Pediatr (Phila). 1999;38:269-72 pubmed
    ..study compares the effectiveness of 10, 15, and 20 days of ceftibuten therapy with 14 days of erythromycin-sulfisoxazole therapy in treating acute sinusitis...
  32. Neumann P, DeDomenico I, Nogrady M. Constipation and urinary tract infection. Pediatrics. 1973;52:241-5 pubmed
  33. Ahlfors C, Marshall G, Wolcott D, Olson D, Van Overmeire B. Measurement of unbound bilirubin by the peroxidase test using Zone Fluidics. Clin Chim Acta. 2006;365:78-85 pubmed
    ..Zone Fluidics can be used to automate the peroxidase test and overcome many of the limitations of the commercially available peroxidase technology. ..
  34. Agarwal R, Gorski J, Sundblad K, Brater D. Urinary protein binding does not affect response to furosemide in patients with nephrotic syndrome. J Am Soc Nephrol. 2000;11:1100-5 pubmed
    ..12 patients with NS were studied to determine whether displacement from urinary protein binding with sulfisoxazole would restore response to 120 mg of furosemide...
  35. Dockrell D, Poland G. Hypercalcemia in a patient with hypoparathyroidism and Nocardia asteroides infection: a novel observation. Mayo Clin Proc. 1997;72:757-60 pubmed
    ..The hypercalcemia resolved after treatment of N. asteroides with sulfisoxazole. Parathyroid hormone and phosphorus levels were within normal limits, and total 25-hydroxyvitamin D levels ..
  36. Derouin F, Chastang C. In vitro effects of folate inhibitors on Toxoplasma gondii. Antimicrob Agents Chemother. 1989;33:1753-9 pubmed
    ..Sulfadiazine, sulfamethoxazole, and sulfisoxazole were all found to have important inhibitory effects on T...
  37. Robertson A, Karp W, Brodersen R. Comparison of the binding characteristics of serum albumins from various animal species. Dev Pharmacol Ther. 1990;15:106-11 pubmed
    ..Using human, rat, guinea pig, and rabbit albumin, we studied the effect of sulfisoxazole, ceftriaxone, and tin protoporphyrin on bilirubin binding...
  38. Eguale T, Gebreyes W, Asrat D, Alemayehu H, Gunn J, Engidawork E. Non-typhoidal Salmonella serotypes, antimicrobial resistance and co-infection with parasites among patients with diarrhea and other gastrointestinal complaints in Addis Ababa, Ethiopia. BMC Infect Dis. 2015;15:497 pubmed publisher
    ..6 %), nitrofurantoin (27; 40.3 %), sulfisoxazole (26; 38.8 %), kanamycin (23; 34.3 %), cephalothin (12; 17.9 %), and ampicillin (11; 16.4 %) respectively...
  39. Ibekwe A, Murinda S, Debroy C, Reddy G. Potential pathogens, antimicrobial patterns and genotypic diversity of Escherichia coli isolates in constructed wetlands treating swine wastewater. FEMS Microbiol Ecol. 2016;92: pubmed publisher
    ..antibiotic resistance prevalence was for tetracycline, followed by erythromycin, ampicillin, streptomycin, sulfisoxazole and kanamycin...
  40. Kuo C, Grayston J. In vitro drug susceptibility of Chlamydia sp. strain TWAR. Antimicrob Agents Chemother. 1988;32:257-8 pubmed
    ..strain TWAR isolates were tested against tetracycline, erythromycin, penicillin, ampicillin, sulfisoxazole, and a new drug, trospectomycin...
  41. Gardiner P, Paine S. The impact of hepatic uptake on the pharmacokinetics of organic anions. Drug Metab Dispos. 2011;39:1930-8 pubmed publisher
    ..In this situation, the potential use of human hepatocytes combined with PBPK modeling avoids the question of which species pharmacokinetics is most predictive to humans. ..
  42. Uchino T, Sanyal S, Yamabe M, Kaku T, Takebayashi S, Shimaoka T, et al. Rescue of pulmonary hypertension with an oral sulfonamide antibiotic sulfisoxazole by endothelin receptor antagonistic actions. Hypertens Res. 2008;31:1781-90 pubmed publisher
    ..This study aimed to examine the possible effects of an orally active ET receptor antagonist, sulfisoxazole (SFX), for the rescue of PH, right ventricular hypertrophy, and eventual right ventricular failure...
  43. Samulak K, El Chaar G, Rubin L. Randomized, double blind comparison of brand and generic antibiotic suspensions: I. A study of taste in adults. Pediatr Infect Dis J. 1996;15:14-17 pubmed
    ..taste of brand and generic erythromycin ethylsuccinate, cephalexin monohydrate, erythromycin ethylsuccinate/sulfisoxazole, penicillin V potassium and trimethoprim-sulfamethoxazole in 42 adult volunteers...
  44. Murata K, Tagawa K, Noda K, Samejima M. Pharmacokinetic analysis of single- or multiple-dose plasma drug concentration data with a microcomputer using multi-fraction absorption models. J Pharm Sci. 1989;78:154-9 pubmed
    ..In addition, application of multi-fraction absorption models to population pharmacokinetics is discussed. ..
  45. McNeeley S, Ryan G, Baselski V. Treatment of chlamydial infections of the cervix during pregnancy. Sex Transm Dis. 1989;16:60-2 pubmed
    ..Eight women received sulfisoxazole 4 gm per day and all responded to therapy...
  46. Aslam M, Stanford K, McAllister T. Characterization of antimicrobial resistance and seasonal prevalence of Escherichia coli O157:H7 recovered from commercial feedlots in Alberta, Canada. Lett Appl Microbiol. 2010;50:320-6 pubmed publisher
    ..Resistance to tetracycline (69%) and sulfisoxazole (68%) was more prevalent in feedlot A than other two feedlots...
  47. Oh K, Baek M, Kang W. Quantitative determination of sulfisoxazole and its three N-acetylated metabolites using HPLC-MS/MS, and the saturable pharmacokinetics of sulfisoxazole in mice. J Pharm Biomed Anal. 2016;129:332-338 pubmed publisher
    b>Sulfisoxazole (SFX) is still used in combination with trimethoprim in cattle despite adverse drug reactions (e.g., urolithiasis). Recently, SFX is known to be a promising repositioned drug candidate for pulmonary hypertension and cancer...
  48. Hansen T, Oyasaeter S, Stiris T, Bratlid D. Effects of sulfisoxazole, hypercarbia, and hyperosmolality on entry of bilirubin and albumin into brain regions in young rats. Biol Neonate. 1989;56:22-30 pubmed
    ..Bilirubin enters the brain both under control, displacer (sulfisoxazole 50 mg/kg), hypercarbic (PCO2 18-21 kPa; pH approximately 6...
  49. Bohdanecká M, Schuck O, Reitschlägerová V, Sedivy J. [Preclinical modeling of the possible effect of acute uremia on drug resorption in the gastrointestinal tract]. Cas Lek Cesk. 1990;129:1431-3 pubmed
    The authors investigated in experiments on rats the course of serum concentrations of sulfisoxazole (S) and acetylsulfisoxazole (AS) in normal rats and in rats after bilateral nephrectomy after intra gastric administration of S...
  50. Alim Z, Kılıç D, Koksal Z, Beydemir S, Ozdemir H. Assessment of the inhibitory effects and molecular docking of some sulfonamides on human serum paraoxonase 1. J Biochem Mol Toxicol. 2017;31: pubmed publisher
    ..2-chloro-4-sülfamoilaniline, 4-amino-3-methylbenzenesulfanilamide, sulfisoxazole, sulfisomidine, and 5-amino-2-methylbenzenesulfonamide)...
  51. Gloff C, Mamelok R, Benet L. Organic anion transport by basal-lateral membranes: effect of PAH and furosemide on each other's transport. Pharmacology. 1988;37:268-76 pubmed
    ..The data suggest that PAH and furosemide are transported by a common carrier-mediated process in the proximal tubule of the rabbit kidney...
  52. Kuang D, Xu X, Meng J, Yang X, Jin H, Shi W, et al. Antimicrobial susceptibility, virulence gene profiles and molecular subtypes of Salmonella Newport isolated from humans and other sources. Infect Genet Evol. 2015;36:294-299 pubmed publisher
    ..Nearly one third of the isolates (31.6%) were resistant to sulfisoxazole, 20.3% to tetracycline and 13.9% to nalidixic acid. Twelve isolates (15...
  53. Hughes W, Killmar J. Synergistic anti-Pneumocystis carinii effects of erythromycin and sulfisoxazole. J Acquir Immune Defic Syndr. 1991;4:532-7 pubmed
    ..prevented in 90% of immunosuppressed rats by the administration of 100 mg of erythromycin and 300 mg/kg/day of sulfisoxazole. All of the untreated control and erythromycin-treated animals developed the infection and 80% of rats given ..