Summary: A sulfathiazole antibacterial agent.

Top Publications

  1. Bjerrum L, Gahrn Hansen B, Grinsted P. Pivmecillinam versus sulfamethizole for short-term treatment of uncomplicated acute cystitis in general practice: a randomized controlled trial. Scand J Prim Health Care. 2009;27:6-11 pubmed publisher
    To investigate whether short-term treatment with pivmecillinam was more effective than sulfamethizole in patients with acute uncomplicated urinary tract infection (UTI). Randomized controlled trial. General practice, Denmark...
  2. Garoma T, Umamaheshwar S, Mumper A. Removal of sulfadiazine, sulfamethizole, sulfamethoxazole, and sulfathiazole from aqueous solution by ozonation. Chemosphere. 2010;79:814-20 pubmed publisher
    The removal of sulfadiazine, sulfamethizole, sulfamethoxazole, and sulfathiazole from aqueous solution by ozonation was studied. The study was conducted experimentally in a semi-batch reactor under different experimental conditions, i.e...
  3. Christensen M, Knuhtsen S, Knudsen E. [Colonic malacoplakia treated with sulfamethizole and trimethoprim]. Ugeskr Laeger. 2011;173:509-10 pubmed
    ..The condition resolved during three months of antibiotic treatment with sulfamethizole and trimethoprim.
  4. Khanfar M, AbuKhader M, Alqtaishat S, Taha M. Pharmacophore modeling, homology modeling, and in silico screening reveal mammalian target of rapamycin inhibitory activities for sotalol, glyburide, metipranolol, sulfamethizole, glipizide, and pioglitazone. J Mol Graph Model. 2013;42:39-49 pubmed publisher
    ..Subsequent in vitro screening of captured hits showed that six of them have submicromolar to low micromolar bioactivities, namely, glyburide, metipranolol, sulfamethizole, glipizide, pioglitazone, and sotalol.
  5. Pose Vilarnovo B, Perdomo López I, Echezarreta López M, Schroth Pardo P, Estrada E, Torres Labandeira J. Improvement of water solubility of sulfamethizole through its complexation with beta- and hydroxypropyl-beta-cyclodextrin. Characterization of the interaction in solution and in solid state. Eur J Pharm Sci. 2001;13:325-31 pubmed
    The aim of this study was to increase the solubility of sulfamethizole in water by complexing it with beta-cyclodextrin (BCD) and hydroxypropyl-beta-cyclodextrin (HPBCD)...
  6. Schmid D, Depta J, Lüthi M, Pichler W. Transfection of drug-specific T-cell receptors into hybridoma cells: tools to monitor drug interaction with T-cell receptors and evaluate cross-reactivity to related compounds. Mol Pharmacol. 2006;70:356-65 pubmed
  7. Imada T, Rino Y, Takahashi M, Hatori S, Tanaka J, Shiozawa M, et al. Gastric emptying after pylorus-preserving gastrectomy in comparison with conventional subtotal gastrectomy for early gastric carcinoma. Surg Today. 1998;28:135-8 pubmed
    ..emptying following pylorus-preserving gastrectomy (PPG) and conventional subtotal gastrectomy (CDG) using sulfamethizole capsule food...
  8. Madsen L. [Peritonsillar abscess in a child caused by ampicillin resistant Haemophilus influenzae]. Ugeskr Laeger. 1990;152:3620 pubmed
    ..Cultivation of pus from the abscess revealed beta-lactamase producing Haemophilus influenzae. The patient was finally successfully treated with sulfamethizole.
  9. Schafers H, Cremer J, Wahlers T, Holle W, Fieguth H, Herrmann G, et al. Pneumocystis carinii pneumonia following heart transplantation. Eur J Cardiothorac Surg. 1987;1:49-52 pubmed
    ..Both patients recovered and are well at the time of this report. ..

More Information


  1. Hossain A, Nakamichi S, Habibullah Al Mamun M, Tani K, Masunaga S, Matsuda H. Occurrence, distribution, ecological and resistance risks of antibiotics in surface water of finfish and shellfish aquaculture in Bangladesh. Chemosphere. 2017;188:329-336 pubmed publisher
    ..97 ng L-1 and 53%), sulfamethazine (SMT) (nd-11.71 ng L-1 and 33%), sulfamethizole (SMZ) (nd-10.81 ng L-1 and 40%) and penicillin G (PC_G) (nd-7...
  2. Reese D, Henning J, Rockers K, Ladd D, Gilson R. Cyclosporine for SJS/TEN: a case series and review of the literature. Cutis. 2011;87:24-9 pubmed
    ..We discuss the proposed mechanism of action and the rationale for the use of cyclosporin based on the currently understood pathophysiologic mechanism of TEN. ..
  3. Liu Z, Yu W, Zhang H, Gu F, Jin X. Salting-out homogenous extraction followed by ionic liquid/ionic liquid liquid-liquid micro-extraction for determination of sulfonamides in blood by high performance liquid chromatography. Talanta. 2016;161:748-754 pubmed publisher
    ..The limits of detection of sulfamethizole (STZ), sulfachlorpyridazine (SCP), sulfamethoxazole (SMX) and Sulfisoxazole (SSZ) were 4.78, 3.99, 5.21 and 3...
  4. Tilden M, Rosenbaum J, Fraunfelder F. Systemic sulfonamides as a cause of bilateral, anterior uveitis. Arch Ophthalmol. 1991;109:67-9 pubmed
    ..Although uveitis secondary to sulfonamides is a rarely diagnosed clinical event, recognition of the distinct presentation of this entity is important in the differential diagnosis of uveitis. ..
  5. Marinella M. Electrocardiographic changes after shoulder arthroplasty. Heart Lung. 2008;37:390-3 pubmed publisher
  6. Nicolle L, Anderson P, Conly J, Mainprize T, Meuser J, Nickel J, et al. Uncomplicated urinary tract infection in women. Current practice and the effect of antibiotic resistance on empiric treatment. Can Fam Physician. 2006;52:612-8 pubmed
    ..Development of guidelines relevant to family physicians and community education programs that incorporate local susceptibility patterns are important strategies for promoting optimal practice. ..
  7. Serpa J, Villarreal Williams E, Giordano T. Prevalence of G6PD deficiency in a large cohort of HIV-infected patients. J Infect. 2010;61:399-402 pubmed publisher
    ..During follow-up, five (6.7%) of these patients developed acute hemolytic anemia. These results provide strong clinical evidence for recommending G6PD testing in HIV-infected subjects from susceptible ethnic backgrounds. ..
  8. Matute A, Hak E, Schurink C, McArthur A, Alonso E, Paniagua M, et al. Resistance of uropathogens in symptomatic urinary tract infections in León, Nicaragua. Int J Antimicrob Agents. 2004;23:506-9 pubmed
    ..The use of amoxicillin, trimethoprim-sulphamethoxazole and cephalothin against uropathogens needs to be reconsidered. High quinolone resistance rates among E. coli in Nicaragua gives cause for great concern...
  9. Kechagia M, Samanidou V, Kabir A, Furton K. One-pot synthesis of a multi-template molecularly imprinted polymer for the extraction of six sulfonamide residues from milk before HPLC with Diode Array Detection. J Sep Sci. 2017;: pubmed publisher
    ..sulfonamide antibiotic residues (sulfanilamide, sulfacetamide, sulfadiazine, sulfathiazole, sulfamerazine and sulfamethizole) in milk samples. Multi-analyte imprinted particles were used as sorbent in solid phase extraction...
  10. Marino D, Jaggy A. Nocardiosis. A literature review with selected case reports in two dogs. J Vet Intern Med. 1993;7:4-11 pubmed
    ..This article reviews current human and veterinary literature regarding the microbiology, pathogenesis, and treatment of nocardiosis and reports on the successful treatment of systemic nocardiosis in two dogs. ..
  11. Sobczyk Krupiarz I, Garlicki A, Biesiada G, Czepiel J, Skwara P, Salamon D, et al. [A case of Salmonella paratyphi A infection in Poland]. Przegl Lek. 2008;65:107-8 pubmed
    ..We present the case of patient who was infected by Salmonella paratyphi C while his travelling in Asia. ..
  12. Katayama K, Tsubota E, Endoh M, Kakemi M, Koizumi T. Effect of iodopyracet on renal excretion of sulfamethizole in rabbits. J Pharmacobiodyn. 1990;13:179-85 pubmed
    ..interaction kinetics from the single-drug clearance studies, we examined the effect of iodopyracet (IOD) on sulfamethizole (SMZ) excretion in rabbits...
  13. Klauson D, Krichevskaya M, Borissova M, Preis S. Aqueous photocatalytic oxidation of sulfamethizole. Environ Technol. 2010;31:1547-55 pubmed publisher
    Aqueous photocatalytic oxidation (PCO) of a non-biodegradable sulphonamide antibiotic sulfamethizole was studied...
  14. Frimodt Møller N. [Sulfamethizole versus pivmecillinam in urinary tract infections]. Ugeskr Laeger. 2003;165:4317; author reply 4317-8 pubmed
  15. Doczeova A, Kolenova A, Beno P, Liskova A, Stanova A, Krcmery V. Antifungal and antibacterial resistance profiles between Cambodia and Kenyan children with human immunodeficiency virus infections receiving trimethoprim-sulfamethoxazole prophylaxis. Pediatr Infect Dis J. 2005;24:1029-30 pubmed
  16. Kobayashi I, Miyachi M, Kanai M, Nagino M, Kondo S, Kamiya J, et al. Different gastric emptying of solid and liquid meals after pylorus-preserving pancreatoduodenectomy. Br J Surg. 1998;85:927-30 pubmed
    ..All patients exhibited delayed solid emptying but fairly good liquid emptying. Gastric function in the early postoperative period after PPPD is characterized by delayed solid-phase but good liquid-phase emptying. ..
  17. Shirani D, Selk Ghaffari M, Akbarein H, Haji Ali Asgari A. Effects of short-term oral administration of trimethoprim-sulfamethoxazole on Schirmer II tear test results in clinically normal rabbits. Vet Rec. 2010;166:623-4 pubmed publisher
    ..Significant decreases in STT-II values were observed in the treatment group on the 14th day of the study in comparison with baseline values (P<0.001). ..
  18. Muder R. Optimizing therapy for Stenotrophomonas maltophilia. Semin Respir Crit Care Med. 2007;28:672-7 pubmed
    ..Further, resistance to this agent is increasing. Certain combinations of antibiotics are synergistic and may be appropriate for patients harboring resistant organisms or with life-threatening infections. ..
  19. Orden Martínez B, Martínez Ruiz R, Millán Pérez R. [What are we learning about Staphylococcus saprophyticus?]. Enferm Infecc Microbiol Clin. 2008;26:495-9 pubmed
    ..This is especially important in pregnant women, who should avoid trimethoprim/sulfamethoxazole and quinolones (FDA Group C), as well as fosfomycin, with in vitro resistance. ..
  20. Nayak R, Call V, Kaldhone P, Tyler C, Anderson G, Phillips S, et al. Comparison of Salmonella enterica serovar Heidelberg susceptibility testing results. Clin Med Res. 2007;5:98-105 pubmed
    ..In general, discrepancies among the methods were due to isolates being interpreted as intermediately susceptible or due to an increased number of resistances detected with Sensititre and a lower number with Vitek. ..
  21. Yoshitomi H, Shizuku Y, Masuda Y, Itakura R, Okamoto S, Tomida H, et al. Evaluation of enteric coated tablet sensitive to pancreatic lipase. II. In vivo evaluation. Biol Pharm Bull. 1993;16:1260-3 pubmed
    Plain tablets containing a model drug, sulfamethizole (SMZ), were coated with triolein (TO), trilaurin (TL) and ethylcellulose (EC)...
  22. Jørgensen G. [Effects of drugs on the liver. A review illustrated with 3 clinical cases]. Ugeskr Laeger. 1994;156:155-61 pubmed
    ..Individual cases of liver disease caused by paracetamol, sulfamethizole and androgenic steroid hormones are presented...
  23. Watanabe A, Ohnuma N. [Crystal morphological and habit investigations of crystalline drugs. III. Sulfamethizole, levodopa and phenobarbital]. Yakugaku Zasshi. 1994;114:80-8 pubmed
    ..necessary for a pharmaceutical technique have been studied by a polarizing microscope for tiny crystals of sulfamethizole, levodopa and phenobarbital listed in the Japanese Pharmacopoeia XII...
  24. Pronina N, Klauson D, Rudenko T, Künnis Beres K, Kamenev I, Kamenev S, et al. Elimination of persistent emerging micropollutants in a suspended-bed photocatalytic reactor: influence of operating conditions and combination with aerobic biological treatment. Photochem Photobiol Sci. 2016;15:1492-1502 pubmed
    ..evaluated for oxidative removal of the persistent pharmaceuticals doxycycline, prednisolone, amoxicillin, and sulfamethizole, as well as their mixture, in ppm concentrations...
  25. Koligi K, Mertz D, Benz D, Vogt T, Bloemberg G, Winter L, et al. [Of bugs and joints. Oligoarthritis caused by Tropheryma whipplei]. Internist (Berl). 2011;52:884-8 pubmed publisher
    ..Antibiotics should be maintained over several months to years. It is prudent to document the disappearance of the pathogen in the affected compartments prior to the discontinuation of the antibiotic therapy. ..
  26. Li Y, Wu X, Li Z, Zhong S, Wang W, Wang A, et al. Fabrication of CoFe2O4-graphene nanocomposite and its application in the magnetic solid phase extraction of sulfonamides from milk samples. Talanta. 2015;144:1279-86 pubmed publisher
    ..Five sulfonamides, including sulfamerazine, sulfamethizole, sulfadoxine, sulfamethoxazole and sulfisoxazole were used as model analytes to evaluate the enrichment ..
  27. Hathaway M, Dayton W, White M, Pampusch M. Effects of antimicrobials and weaning on porcine serum insulin-like growth factor binding protein levels. J Anim Sci. 2003;81:1456-63 pubmed
    ..05) compared with pigs fed the control diet. Both Aureozol-supplementation and weaning cause changes in serum IGFBP levels and IGF-I concentrations that might be involved in regulating rate and efficiency of growth. ..
  28. Wang L, Li Y, Wang L, Zhang H, Zhu M, Zhang P, et al. Extracellular polymeric substances affect the responses of multi-species biofilms in the presence of sulfamethizole. Environ Pollut. 2018;235:283-292 pubmed publisher
    ..In this study, the effects of EPS on the sorption and biological responses to one representative antibiotic, sulfamethizole (STZ), in model biofilms were investigated...
  29. Hoffmann H, Baldofski S, Hoffmann K, Flemig S, Silva C, Esteves V, et al. Structural considerations on the selectivity of an immunoassay for sulfamethoxazole. Talanta. 2016;158:198-207 pubmed publisher
    ..The crystal structures of the cross-reacting compounds sulfamethizole, N(4)-acetyl-SMX and succinimidyl-SMX were determined by x-ray diffraction aiming to explain their high cross-..
  30. Wang L, Li Y, Wang L, Zhu M, Zhu X, Qian C, et al. Responses of biofilm microorganisms from moving bed biofilm reactor to antibiotics exposure: Protective role of extracellular polymeric substances. Bioresour Technol. 2018;254:268-277 pubmed publisher
    ..The adsorbed amounts of antibiotics onto EPS accounted for 14.5%, 88.2% and 13.1% of total concentration for sulfamethizole, tetracycline and norfloxacin, respectively at the biodegradation stage...
  31. Wissmann G, Alvarez Martinez M, Meshnick S, Dihel A, Prolla J. Absence of dihydropteroate synthase mutations in Pneumocystis jirovecii from Brazilian AIDS patients. J Eukaryot Microbiol. 2006;53:305-7 pubmed
    ..4%), including five cases (8.7%) that had used sulfa prophylaxis. No DHPS gene mutations were seen. These results suggest that DHPS mutations are currently as rare in Brazil as in other developing countries. ..
  32. Ratanajamit C, Skriver M, Nørgaard M, Jepsen P, Schønheyder H, Sørensen H. Adverse pregnancy outcome in users of sulfamethizole during pregnancy: a population-based observational study. J Antimicrob Chemother. 2003;52:837-41 pubmed
    To estimate the risk of adverse birth and neonatal outcome, and miscarriage in women who used sulfamethizole during pregnancy...
  33. Lum C, Vadmal M. Case report: Nocardia asteroides mycetoma. Ann Clin Lab Sci. 2003;33:329-33 pubmed
  34. Ayankojo A, Tretjakov A, Reut J, Boroznjak R, Öpik A, Rappich J, et al. Molecularly Imprinted Polymer Integrated with a Surface Acoustic Wave Technique for Detection of Sulfamethizole. Anal Chem. 2016;88:1476-84 pubmed publisher
    ..imprinting and surface acoustic wave (SAW) technologies for the selective and label-free detection of sulfamethizole as a model antibiotic in aqueous environment was demonstrated...
  35. Katayama K, Ohtani H, Kawabe T, Mizuno H, Endoh M, Kakemi M, et al. Kinetic studies on drug disposition in rabbits. I. Renal excretion of iodopyracet and sulfamethizole. J Pharmacobiodyn. 1990;13:97-107 pubmed
    In order to quantify the renal handling of iodopyracet (IOD) and sulfamethizole (SMZ), single-drug clearance studies in rabbits were performed under quasi-steady state conditions with stepwise increasing the infusion rate of IOD or SMZ...
  36. Feng L, Casas M, Ottosen L, Møller H, Bester K. Removal of antibiotics during the anaerobic digestion of pig manure. Sci Total Environ. 2017;603-604:219-225 pubmed publisher
    ..In this study, the removal patterns of sulfonamides (sulfadiazine, sulfamethizole, sulfamethoxazole) and macrolides (clarithromycin, erythromycin), as well as trimethoprim, were investigated ..
  37. Bjerrum L, Dessau R, Hallas J. [Prescriptions of a new antibiotic following treatment with sulfamethizole or pivmecillinam]. Ugeskr Laeger. 2003;165:3732-5 pubmed
  38. Ensink J, Smit J, van Duijkeren E. Clinical efficacy of trimethoprim/sulfadiazine and procaine penicillin G in a Streptococcus equi subsp. zooepidemicus infection model in ponies. J Vet Pharmacol Ther. 2003;26:247-52 pubmed
    ..The most probable cause of the failure of TMP/SDZ to eliminate the streptococci is inhibition of the action of TMP/SDZ in the purulent TCF. Therefore, TMP/SDZ should not be used to treat purulent infections in secluded sites in horses. ..
  39. Bartoloni A, Fanci R, Orsi A, Aquilini D, Bosi A, Rossi Ferrini P, et al. The influence of ofloxacin versus trimethoprim-sulfamethoxazole on the aerobic flora in granulocytopenic subjects. J Chemother. 1989;1:91-4 pubmed
    ..Both groups acquired new microorganisms, prevalently gram-positive cocci, but also gram-negative bacteria with the TMP-SMZ regimen. Both treatment groups acquired yeasts. ..
  40. Wambaugh M, Shakya V, Lewis A, Mulvey M, Brown J. High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance. PLoS Biol. 2017;15:e2001644 pubmed publisher
    ..As a proof of concept, we focus on combinations with the antibiotics trimethoprim and sulfamethizole, which had been standard treatment against urinary tract infections until widespread resistance decreased ..
  41. Mezyk S, Neubauer T, Cooper W, Peller J. Free-radical-induced oxidative and reductive degradation of sulfa drugs in water: absolute kinetics and efficiencies of hydroxyl radical and hydrated electron reactions. J Phys Chem A. 2007;111:9019-24 pubmed
    ..For sulfamethazine, sulfamethizole, sulfamethoxazole, and sulfamerazine, absolute rate constants for hydroxyl radical oxidation were determined ..
  42. Katayama K, Ohtani H, Mizuno H, Taniguchi T, Kakemi M, Koizumi T. Kinetic studies on drug disposition in rabbits. III. Effect of tolbutamide on renal excretion of sulfamethizole. J Pharmacobiodyn. 1990;13:120-9 pubmed
    The effect of tolbutamide (TB) on the urinary excretion of sulfamethizole (SMZ) under constant infusion of SMZ at 100 mg/h was studied...
  43. Quigley K, Deasy P. Use of deacetylated gellan gum (Gelrite) for the production of sulphamethizole containing beads. J Microencapsul. 1992;9:1-7 pubmed
  44. Ge P, Yu H, Chen J, Qu J, Luo Y. Photolysis mechanism of sulfonamide moiety in five-membered sulfonamides: A DFT study. Chemosphere. 2018;197:569-575 pubmed publisher
    ..sulfonamide moiety of five-membered sulfonamide (SA) antibiotics, such as sulfamethoxazole, sulfisoxazole, sulfamethizole, and sulfathiazole...
  45. Watanabe H, Hastings J. Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine. Biochim Biophys Acta. 1990;1017:229-34 pubmed
    ..In sensitivity tests with Photobacterium phosphoreum, using 55 different antibiotics, it was found that sulfamethizole, an inhibitor of dihydropteroate synthetase and the formation of folic acid, inhibited bioluminescence more ..
  46. Rathlavath S, Kohli V, Singh A, Lekshmi M, Tripathi G, Kumar S, et al. Virulence genotypes and antimicrobial susceptibility patterns of Arcobacter butzleri isolated from seafood and its environment. Int J Food Microbiol. 2017;263:32-37 pubmed publisher
    ..butzleri is important to understand the evolution of antibiotic resistance in this emerging food pathogen and to determine the antimicrobial therapy regimen in the event of food-borne A. butzleri infections. ..
  47. Høiby N. [Kernicterus and sulfamethizole treatment]. Ugeskr Laeger. 2006;168:1349-50; author reply 1350-1 pubmed
  48. Taraszewski R, Harvey R, Rosman P. Death from drug-induced hemolytic anemia. Postgrad Med. 1989;85:79-80, 84 pubmed
    ..Although hematologic complications of trimethoprim-sulfamethoxazole treatment usually follow long-term or high-dose therapy, acute reactions apparently may occur at lower doses as well. ..
  49. Zohar S, Golz A, Abraham S. Peritonsillar abscess in an infant. Int J Pediatr Otorhinolaryngol. 1988;15:291-4 pubmed
    ..Here, the diagnosis was somewhat doubtful, due to the uncharacteristic clinical appearance and the young age of the patient. Some of the dangers of an inadequate antibiotic treatment are briefly discussed...
  50. Murakami T, Kohno K, Yumoto R, Higashi Y, Yata N. N-acetyl-L-gamma-glutamyl derivatives of p-nitroaniline, sulphamethoxazole and sulphamethizole for kidney-specific drug delivery in rats. J Pharm Pharmacol. 1998;50:459-65 pubmed
    ..Results related to the selectivity of tissue distribution of the derivatives and species differences are discussed. ..
  51. Moon S, Kim T, Sung H, Kim M, Kim S, Choi S, et al. Outcomes of moderate-to-severe Pneumocystis pneumonia treated with adjunctive steroid in non-HIV-infected patients. Antimicrob Agents Chemother. 2011;55:4613-8 pubmed publisher
    ..81). There again was no difference within the subgroup of PcP patients with solid-organ transplants. Adjunctive corticosteroid use may not improve the outcome of moderate-to-severe PcP in non-HIV-infected patients. ..
  52. Kouklakis G, Mpoumponaris A, Zezos P, Moschos J, Koulaouzidis A, Nakos A, et al. Cholestatic hepatitis with severe systemic reactions induced by trimethoprim-sulfamethoxazole. Ann Hepatol. 2007;6:63-5 pubmed
    ..He had fully recovered months later. All tests for other causes of liver disease were negative and his liver biopsy showed evidence of drug-induced hepatic injury. ..
  53. Yuksel N, Aydmli A, Ozalp Y, Ozdemir N. Evaluation and preparation of controlled release lipid micropheres of sulphamethizole by a congealable disperse phase encapsulation method. Acta Pol Pharm. 2000;57:187-92 pubmed
    ..Furthermore, in vivo study on 6 healthy volunteers confirmed the controlled release pattern of this dosage form. ..