Summary: Long acting sulfonamide antibacterial agent.

Top Publications

  1. Ito H, Ishida H, Collins B, Fromholt S, Schnaar R, Kiso M. Systematic synthesis and MAG-binding activity of novel sulfated GM1b analogues as mimics of Chol-1 (alpha-series) gangliosides: highly active ligands for neural siglecs. Carbohydr Res. 2003;338:1621-39 pubmed
    ..Among the synthetic gangliosides, GSC-338 (II3III6-disulfate of iso-GM1b) was surprisingly found to be the most potent MAG binding structure tested to date. ..
  2. Girardi C, Re G, Farca A, Dacasto M, Ferrero E, Eandi M. Blood kinetics of sulfamonomethoxine and oxytetracycline following intrauterine spray injection in dairy cows. Pharmacol Res. 1990;22:79-86 pubmed
    ..administration was performed in six Friesan cows with a disposable spray preparation containing 3 g of sulfamonomethoxine and 3 g of oxytetracycline, in order to investigate their serum kinetics...
  3. Furusawa N. Determining sulfamonomethoxine and its acetyl/hydroxyl metabolites in chicken plasma under organic solvent-free conditions. Anal Bioanal Chem. 2006;385:1570-4 pubmed
    ..preparation followed by high performance liquid chromatography method for the simultaneous determination of sulfamonomethoxine and its metabolites, N4-acetyl SMM and 2,6-dihydroxy SMM, in chicken plasma...
  4. Vree T, Vree J, Beneken Kolmer N, Hekster Y, Shimoda M, Nouws J, et al. Oxidation and O-dealkylation of sulphamonomethoxine by the turtle Pseudemys scripta elegans. Vet Q. 1989;11:186-90 pubmed
    ..No N4-acetylation takes place. The yield of the oxidation reaction is twice that of the O-demethylation reaction. ..
  5. Chullasat K, Nurerk P, Kanatharana P, Kueseng P, Sukchuay T, Bunkoed O. Hybrid monolith sorbent of polypyrrole-coated graphene oxide incorporated into a polyvinyl alcohol cryogel for extraction and enrichment of sulfonamides from water samples. Anal Chim Acta. 2017;961:59-66 pubmed publisher
    ..10 to 100 ?g L-1 for sulfamethazine, sulfamonomethoxine and sulfadimethoxine. The limits of detection were 0...
  6. Ogata F, Tominaga H, Kangawa M, Inoue K, Kawasaki N. Removal of sulfa drugs by sewage treatment in aqueous solution systems: activated carbon treatment and ozone oxidation. J Oleo Sci. 2012;61:217-25 pubmed
    ..the activated carbon (AC) treatment and ozone oxidation of the sulfa drugs--sulfamethoxazole (SMX), sulfamonomethoxine (SMM), sulfadimidine (SDD), and sulfadimethoxine (SDM)--in aqueous solution systems...
  7. Togame H, Shimazaki M, Yamato A, Watanabe S, Saito K, Reinemer P. Development of a simple homogeneous assay to screen for inhibitors of N-acetylglucosamine-6-sulfotransferases. Anal Biochem. 2003;315:67-76 pubmed
    ..1 microM. The assay can be operated in 384-well format; is characterized by a high signal-to-noise ratio, low variation, and excellent Z factors; and is highly suitable for high-throughput screening. ..
  8. Furusawa N, Mukai T. Transfer of dietary sulphamonomethoxine and sulphadimethoxine into various tissues of laying hens. Br Poult Sci. 1995;36:313-6 pubmed
    ..5. With the exception of adipose tissue, the values of SDM in the tissues were statistically greater than those of SMM. ..
  9. Carli S, Sonzogni O, Villa R, Bignazzi R, Montesissa C. Pharmacokinetic profile of sulphamonomethoxine-trimethoprim in horses after intravenous, intramuscular and oral administration. Res Vet Sci. 1993;54:184-8 pubmed

More Information


  1. Shimoda M, Okamoto K, Sikazwe G, Fujii C, Son D. Deacetylation as a determinant of sulphonamide pharmacokinetics in pigs. Vet Q. 1997;19:186-91 pubmed
    ..It was, however, not a determinant of SDZ pharmacokinetics because N4-acetylation is not the main elimination route in pigs. ..
  2. Li T, Qiao G, Hu G, Meng F, Qiu Y, Zhang X, et al. Comparative plasma and tissue pharmacokinetics and drug residue profiles of different chemotherapeutants in fowls and rabbits. J Vet Pharmacol Ther. 1995;18:260-73 pubmed
    ..Ceftriaxone (CEF), intravenously at 50 mg/kg, sulfamonomethoxine (SMM) and sulfaquinoxaline (SQ), orally at 200 mg/kg, and olaquindox (OLA), orally at 50 mg/kg, were ..
  3. Pi Y, Feng J, Sun J, Sun J. Facile, effective, and environment-friendly degradation of sulfamonomethoxine in aqueous solution with the aid of a UV/Oxone oxidative process. Environ Sci Pollut Res Int. 2013;20:8621-8 pubmed publisher
    The degradation of sulfamonomethoxine (SMM) in the aqueous environment by the combination of UV illumination and Oxone has been studied...
  4. Kuwano A, Ito T, Tachi H, Hiramune T. Comparison of the inhibitory effect of sulfamonomethoxine and other sulfonamides on capsule formation of Bordetella bronchiseptica. J Vet Med Sci. 1992;54:1057-9 pubmed
    The inhibitory effect of sulfamonomethoxine and other sulfonamides on the capsule formation of sulfonamide-resistant Bordetella bronchiseptica was investigated...
  5. Yan J, Lei M, Zhu L, Anjum M, Zou J, Tang H. Degradation of sulfamonomethoxine with Fe3O4 magnetic nanoparticles as heterogeneous activator of persulfate. J Hazard Mater. 2011;186:1398-404 pubmed publisher
    ..The kinetics of sulfamonomethoxine (SMM) degradation was studied in the system of Fe(3)O(4) MNPs and S(2)O(8)(2-)...
  6. Furusawa N. Hepatic biotransformation profiles of sulphamonomethoxine in food-producing animals and rats in vitro. Acta Vet Hung. 2000;48:293-300 pubmed
    ..All S-9s from the four species deacetylated N4-AcSMM. In hen S-9s, the rate of 2,6-dihydroxylation was higher during incubation at 41 degrees C than at 37 degrees C. ..
  7. Furusawa N. Binding profile of spiramycin to oviducal proteins of laying hens. J Vet Med A Physiol Pathol Clin Med. 2000;47:585-91 pubmed
    ..Of plasma, M-S9 and IS-S9, variation in SP concentration in the ranges from 1 to 20 micrograms/ml did not alter the binding properties of the drug. ..
  8. Hasbullah -, Itahana H, Uchida T, Inamoto T, Nakai Y, Ogimoto K. Medication of feedlot calves infected with Eimeria spp. by a combination of sulfamonomethoxine and ormetoprim. J Vet Med Sci. 1996;58:169-70 pubmed
    Feedlot calves naturally infected with Eimeria spp. were medicated by a combination of sulfamonomethoxine and ormetoprim (Ektecin)...
  9. Kuwano A. Inhibitory effect of sulfamonomethoxine on capsule formation of Bordetella bronchiseptica. Zentralbl Veterinarmed B. 1991;38:685-8 pubmed
    ..The present study examines the effect of sulfamonomethoxine (SMMX) on capsule formation of B. bronchiseptica...
  10. Zhang Y, Wu Y. [Determination of residual sulfonamides in meat by high performance liquid chromatography with solid-phase extraction]. Se Pu. 2005;23:636-8 pubmed
    A method was developed for determining residual sulfonamides (SAs) such as sulfamethazine (SM2), sulfamonomethoxine (SMM), sulfamethiazole (SMZ), sulfadimethoxine (SDM) and sulfaquinoxaline (SQ) in pork and chicken using solid-phase ..
  11. Qin Y, Zhang M, Lin H. [Qualification and quantification of 10 sulfonamides in animal feedstuff by high performance liquid chromatography-electrospray tandem mass spectrometry]. Se Pu. 2005;23:397-400 pubmed
    ..SM1), sulfameter (SM), sulfamethazine (SM2), sulfamethoxypyridazine (SMP), sulfamethoxazole (SMZ), sulfamonomethoxine (SMM), sulfadimethoxine (SDM) and sulfaquinoxaline (SQX)...
  12. Nomura Y, Fukahori S, Fukada H, Fujiwara T. Removal behaviors of sulfamonomethoxine and its degradation intermediates in fresh aquaculture wastewater using zeolite/TiO2 composites. J Hazard Mater. 2017;340:427-434 pubmed publisher
    Removal efficiencies of sulfamonomethoxine (SMM) and its degradation intermediates formed by treatment with zeolite/TiO2 composites through adsorption and photocatalysis were investigated in fresh aquaculture wastewater (FAWW)...
  13. Ueno R, Aoki T. High-performance liquid chromatographic method for the rapid and simultaneous determination of sulfamonomethoxine, miloxacin and oxolinic acid in serum and muscle of cultured fish. J Chromatogr B Biomed Appl. 1996;682:179-81 pubmed
    A rapid method for the simultaneous determination of sulfamonomethoxine (SMM), miloxacin (MLX) and oxolinic acid (OA) in serum and muscle of cultured fish by high-performance liquid chromatography has been developed...
  14. Chen J, Liu Y, Zhang J, Yang Y, Hu L, Yang Y, et al. Removal of antibiotics from piggery wastewater by biological aerated filter system: Treatment efficiency and biodegradation kinetics. Bioresour Technol. 2017;238:70-77 pubmed publisher
    ..Nine antibiotics including sulfamonomethoxine, sulfachloropyridazine, sulfamethazine, trimethoprim, norfloxacin, ofloxacin, lincomycin, leucomycin and ..
  15. Gao M, Yan H, Sun N. Water-compatible poly (hydroxyethyl methacrylate) polymer sorbent for miniaturized syringe assisted extraction of sulfonamides in milk. Anal Chim Acta. 2013;800:43-9 pubmed publisher sorbent coupled with liquid chromatography was proposed for rapid screening of sulfadiazine (SD) and sulfamonomethoxine (SMM) in milk...
  16. Zhang G, Wang X, Zhi A, Bao Y, Yang Y, Qu M, et al. Development of a lateral flow immunoassay strip for screening of sulfamonomethoxine residues. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008;25:413-23 pubmed publisher
    A rapid lateral flow immunoassay screening method has been developed for the determination of sulfamonomethoxine (SMM) residues in swine urine...
  17. Furusawa N. Determination of sulfonamide residues in eggs by liquid chromatography. J AOAC Int. 2002;85:848-52 pubmed
    A method was developed for determining residual sulfonamide antibacterials such as sulfamethazine (SMZ), sulfamonomethoxine (SMM), sulfadimethoxine (SDM), and sulfaquinoxaline (SQ) in eggs using liquid chromatography with a photodiode ..
  18. Yang S, Lin C, Lin A, Hong P. Sorption and biodegradation of sulfonamide antibiotics by activated sludge: experimental assessment using batch data obtained under aerobic conditions. Water Res. 2011;45:3389-97 pubmed publisher
    ..Three sulfonamide antibiotics including sulfamethoxazole (SMX), sulfadimethoxine (SDM), and sulfamonomethoxine (SMM), which had been detected in the influent and the activated sludge of wastewater treatment plants (WWTP)..
  19. Zheng H, Wang P, Li J. [Determination of 12 sulfonamides in cosmetics by ultra performance liquid chromatography]. Se Pu. 2007;25:238-40 pubmed
    A method for the determination of 12 sulfonamides (SAs) (sulfanilamide, sulfamonomethoxine, sulfacetamide, sulfamethoxazole, sulfadiazine, sulfisoxazole, sulfathiazole, sulfadi-methoxine, sulfamerazine, sulfaquinoxaline, sulfamethazine, ..
  20. Kamiyama S, Ichimiya T, Ikehara Y, Takase T, Fujimoto I, Suda T, et al. Expression and the role of 3'-phosphoadenosine 5'-phosphosulfate transporters in human colorectal carcinoma. Glycobiology. 2011;21:235-46 pubmed publisher
    ..These findings indicate that PAPS transporters play a role in the proliferation of colorectal carcinoma cells themselves and take part in a desmoplastic reaction to support cancer growth by controlling their sulfation status. ..
  21. Seta N, Shimizu T, Nawata M, Wada R, Mori K, Sekigawa I, et al. A possible novel mechanism of opportunistic infection in systemic lupus erythematosus, based on a case of toxoplasmic encephalopathy. Rheumatology (Oxford). 2002;41:1072-3 pubmed
  22. Shimoda M, Kokue E, Shimizu T, Muraoka R, Hayama T. Role of deacetylation in the nonlinear pharmacokinetics of sulfamonomethoxine in pigs. J Pharmacobiodyn. 1988;11:576-82 pubmed
    The role of deacetylation in the pharmacokinetics of sulfamonomethoxine (SMM) in pigs was studied using 6 Goettingen minipigs and a pig from a commercial breed...
  23. Zhang Q, Zhang D, Ye K, Liu K, Sheng J, Liu Y, et al. Physiological and behavioral responses in offspring mice following maternal exposure to sulfamonomethoxine during pregnancy. Neurosci Lett. 2016;624:8-16 pubmed publisher
    b>Sulfamonomethoxine (SMM), a veterinary antibiotic, is widely used in China. However, the impacts of maternal SMM exposure on neurobehavioral development in early life remain little known...
  24. Furusawa N. Absorbability of sulphamonomethoxine and sulphadimethoxine administered via food of laying hens. Zentralbl Veterinarmed A. 1998;45:267-9 pubmed
    ..Average amounts of SMM and SDM in the dry matter of the large intestine were 12.3 and 30.2 p.p.m., respectively. The absorption ratios of SMM and SDM administered via the food were calculated to be 96.9 and 92.5%, respectively. ..
  25. Yan J, Tang H, Lin Z, Anjum M, Zhu L. Efficient degradation of organic pollutants with ferrous hydroxide colloids as heterogeneous Fenton-like activator of hydrogen peroxide. Chemosphere. 2012;87:111-7 pubmed publisher
    ..and characterized as an activator of H(2)O(2) for decomposing organic pollutants, such as Rhodamine B, sulfamonomethoxine (SMM) and 4-nitrophenol (4-NP)...
  26. Vree T, Beneken Kolmer W, Hekster Y, Shimoda M, Ono M, Miura T. Pharmacokinetics and acetylation of sulfa-2-monomethoxine in humans. Biopharm Drug Dispos. 1992;13:55-68 pubmed
    ..Approximately 80 per cent of the oral dose of S is excreted in the urine as parent drug (41.0 +/- 6.2 per cent) and as N4 acetyl conjugate (39.9 +/- 8.0 per cent). ..
  27. Carrino D, Calabro A, Darr A, Dours Zimmermann M, Sandy J, Zimmermann D, et al. Age-related differences in human skin proteoglycans. Glycobiology. 2011;21:257-68 pubmed publisher
    ..These age-related differences in proteoglycan patterns and catabolism may play a role in the age-related changes in the physical properties and injury response of human skin. ..
  28. Vree T, Vree M, Beneken Kolmer E, Hekster Y, Shimoda M, Ono M, et al. O-Dealkylation and N4-acetylation of sulpha-2-monomethoxine by the turtle Pseudemys scripta elegans. Vet Q. 1991;13:176-80 pubmed
    ..Sulpha-2-monomethoxine is N4-acetylated to an extent of 12% of the dose by Pseudemys scripta elegans; 48% is excreted unchanged. No O-dealkylation of the 2-methoxy group takes place. ..
  29. Gao G, Jiao Q, Ding Y, Chen L. [Study on the mechanism of the interaction of methylene blue and sulfation pachymaran]. Guang Pu Xue Yu Guang Pu Fen Xi. 2005;25:608-12 pubmed
  30. Furusawa N, Mukai T. Simultaneous high-performance liquid chromatographic determination of residual sulphamonomethoxine, sulphadimethoxine and their N4-acetyl metabolites in foods of animal origin. J Chromatogr A. 1994;677:81-5 pubmed
    ..The average recoveries from spiked meat and egg were in excess of 80% with relative standard deviations between 0.4 and 5.0%. The practical limits of detection were 0.01 ppm for all samples. ..
  31. Lin H, Jin D, Freitag T, Sun W, Yu Q, Fu J, et al. A compositional shift in the soil microbiome induced by tetracycline, sulfamonomethoxine and ciprofloxacin entering a plant-soil system. Environ Pollut. 2016;212:440-448 pubmed publisher
    ..This study investigated the effects of tetracycline (TC), sulfamonomethoxine (SMM), ciprofloxacin (CIP) and their combination (AM) on the bacterial community in a soil-microbe-plant ..
  32. Uno K, Maeda I. Simultaneous determination of sulphamonomethoxine and its N4-acetyl metabolite in blood serum by high-performance liquid chromatography with direct injection. J Chromatogr B Biomed Appl. 1995;663:177-80 pubmed
    ..5, 2.0 and 10.0 micrograms/ml) were 93-103% and 90-103%, respectively. The lowest measurable sulphamonomethoxine and N4-acetyl metabolite concentrations were 0.04 and 0.1 microgram/ml, respectively, for all serum samples. ..
  33. Kishida K, Furusawa N. Application of shielded column liquid chromatography for determination of sulfamonomethoxine, sulfadimethoxine, and their N4-acetyl metabolites in milk. J Chromatogr A. 2004;1028:175-7 pubmed
    A hazardous-chemical free method for simultaneous determination of sulfamonomethoxine (SMM), sulfadimethoxine (SDM), and their N4-acetyl metabolites in raw milk using shielded column liquid chromatography is developed...
  34. Furusawa N. Spiramycin, oxytetracycline and sulphamonomethoxine contents of eggs and egg-forming tissues of laying hens. Zentralbl Veterinarmed A. 1999;46:599-603 pubmed
    ..Low concentrations of SP were measured in the blood, whereas contents in the liver and the oviducts were relatively much higher. ..
  35. Kokue E, Shimoda M, Sakurada K, Wada J. Pharmacokinetics of oral sulfa drugs and gastric emptying in the pig. J Pharmacobiodyn. 1988;11:549-54 pubmed
    The plasma pharmacokinetics of sulfamonomethoxine (SMM) and sulfamethazine (SMZ) in the pig were examined after the oral and intravenous (i.v.) administration of the sodium salt solutions...
  36. Song C, Li L, Zhang C, Kamira B, Qiu L, Fan L, et al. Occurrence and human dietary assessment of sulfonamide antibiotics in cultured fish around Tai Lake, China. Environ Sci Pollut Res Int. 2017;24:17493-17499 pubmed publisher
    ..1 to 10 ?g kg-1. Sulfadiazine (SDZ), sulfamethoxazole (SMZ), sulfamethazine (SDD), and sulfamonomethoxine (SMM) were the main types of antibiotics used, and these were present at high concentrations (>100 ?g ..
  37. Wang W, Gu X, Zhou L, Chen H, Zeng Q, Mao Z. Antibiotics in Crab Ponds of Lake Guchenghu Basin, China: Occurrence, Temporal Variations, and Ecological Risks. Int J Environ Res Public Health. 2018;15: pubmed publisher
    ..of five crab ponds, among which sulfonamides and macrolides were the predominant classes, and six compounds (sulfamonomethoxine, sulfadiazine, trimethoprim, erythromycin-Hâ‚‚O, monensin, and florfenicol) were frequently detected at ..
  38. Jia A, Hu J, Wu X, Peng H, Wu S, Dong Z. Occurrence and source apportionment of sulfonamides and their metabolites in Liaodong Bay and the adjacent Liao River basin, North China. Environ Toxicol Chem. 2011;30:1252-60 pubmed publisher
    ..6?ng/L), N-acetylsulfamethoxazole (63.1?ng/L), trimethoprim (29.0?ng/L), sulfadiazine (14.0?ng/L), and sulfamonomethoxine (8...
  39. Furusawa N, Mukai T, Ohori H. Depletion of dietary sulphamonomethoxine and sulphadimethoxine from various tissues of laying hens. Br Poult Sci. 1996;37:435-42 pubmed
    ..The reason for this is probably related to the longer time period over which albumen formation occurs. ..
  40. Song C, Zhang C, Fan L, Qiu L, Wu W, Meng S, et al. Occurrence of antibiotics and their impacts to primary productivity in fishponds around Tai Lake, China. Chemosphere. 2016;161:127-135 pubmed publisher
    ..Sulfonamides were the most prevalent, and concentrations of sulfamethoxazole, sulfamonomethoxine, and florfenicol being over 2000 ng L(-1) in some samples, while the other antibiotics levels ranged from ..
  41. Jin C, Chen Q, Sun R, Zhou Q, Liu J. Eco-toxic effects of sulfadiazine sodium, sulfamonomethoxine sodium and enrofloxacin on wheat, Chinese cabbage and tomato. Ecotoxicology. 2009;18:878-85 pubmed publisher
    Investigation of the toxic effects of three veterinary drugs [sulfadiazine sodium (SDS), sulfamonomethoxine sodium (SMMS), and enrofloxacin (EFLX)] on seed germination, root elongation and shoot elongation of wheat (Triticum aestivum L...
  42. Vree T, Beneken Kolmer E, Hekster Y, Shimoda M, Ono M, Miura T. Pharmacokinetics, N1-glucuronidation, and N4-acetylation of sulfa-6-monomethoxine in humans. Drug Metab Dispos. 1990;18:852-8 pubmed
    b>Sulfamonomethoxine (S) is metabolized by O-dealkylation, N4-acetylation, and N1-glucuronidation. In humans, only N1-glucuronidation (12%) and N4-acetylation (36%) takes place. The N1-glucuronide is directly measured by HPLC...