Summary: A sulfanilamide antibacterial agent.

Top Publications

  1. Abdennebi E, Bousfiha A, Ben Goumi M, Oukessou M. [Pharmacokinetics and plasma protein binding of sulfamethoxypyridazine in camels (Camelus dromedarius)]. Rev Elev Med Vet Pays Trop. 1994;47:97-102 pubmed
    The pharmacokinetics of sulfamethoxypyridazine (SMPD) were investigated in the camel after intravenous and oral administration...
  2. Constant Desportes M, Guelpa Lauras C, Carolina J, Léoture A, Grosset J, Sansarricq H. A case of relapse with drug-susceptible M. leprae after multidrug therapy. Int J Lepr Other Mycobact Dis. 1991;59:242-7 pubmed 1930 was diagnosed as smear-positive borderline leprosy in 1971, and was treated with dapsone and/or sulfamethoxypyridazine from 1972 to 1980 with clinical improvement...
  3. Xia L, Liu L, Lv X, Qu F, Li G, You J. Towards the determination of sulfonamides in meat samples: A magnetic and mesoporous metal-organic framework as an efficient sorbent for magnetic solid phase extraction combined with high-performance liquid chromatography. J Chromatogr A. 2017;1500:24-31 pubmed publisher
    ..5 SAs, including sulfadiazine (SDZ), sulfathiazole (STZ), sulfamerazine (SMR), sulfamethazine (SMZ), and sulfamethoxypyridazine (SMP), was developed. The method exhibited good linearity in the range of 3...
  4. Hughes J, Erhardt C, Clement M. Neutrophilic dermatosis in association with rheumatoid arthritis. Clin Exp Dermatol. 1995;20:168-70 pubmed
    ..The rash recurred on withdrawal of the dapsone but has responded to sulphamethoxypyridamine. It is proposed that this condition is a rare but specific entity of unknown cause associated with rheumatoid arthritis. ..
  5. López Martínez L, López de Alba P, de Leon Rodriguez L, Yepez Murrieta M. Simultaneous determination of binary mixtures of trimethoprim and sulfamethoxazole or sulphamethoxypyridazine by the bivariate calibration spectrophotometric method. J Pharm Biomed Anal. 2002;30:77-85 pubmed
    ..However, the advantage of bivariate calibration is its simplicity, due to the minimal spectra manipulation when compared with derivative techniques. ..
  6. Garg S, Uppal R. Bioavailability of sulfamethoxypyridazine following intramuscular or subcutaneous administration in goats. Vet Res. 1997;28:101-4 pubmed
    The pharmacokinetics of sulfamethoxypyridazine (SMP) was investigated in goats after a single intramuscular (im) or subcutaneous (sc) administration (100 mg/kg body weight)...
  7. Wang Z, Zhang S, Nesterenko I, Eremin S, Shen J. Monoclonal antibody-based fluorescence polarization immunoassay for sulfamethoxypyridazine and sulfachloropyridazine. J Agric Food Chem. 2007;55:6871-8 pubmed
    In this paper, a new monoclonal antibody (Mab) against sulfamethoxypyridazine (SMP) was produced, and a fluorescence polarization immunoassay (FPIA) based on the produced Mab was developed and optimized for the qualitative screening ..
  8. Rademacher U, Jakob W, Bockhardt I. Cryptosporidium infection in beech martens (Martes foina). J Zoo Wildl Med. 1999;30:421-2 pubmed
    ..The oocysts were 3-5 microns, which is consistent with C. parvum. The source of the Cryptosporidium infection remained unknown. This is the first demonstration of Cryptosporidium in beech martens. ..
  9. Sainz Diaz C, Francisco Marquez M, Soriano Correa C. Polymorphism, Intermolecular Interactions, and Spectroscopic Properties in Crystal Structures of Sulfonamides. J Pharm Sci. 2018;107:273-285 pubmed publisher
    ..The intermolecular interactions in the crystal polymorphs of the sulfonamides, sulfamethoxypyridazine, and sulfamethoxydiazine, as models of sulfonamides, have been studied by using quantum mechanical ..

More Information


  1. Roudaut B, Garnier M. Sulphonamide and dapsone residues in bovine milk following intramammary infusion. Food Addit Contam. 1993;10:461-8 pubmed
    ..The diffusion of residues into milk from a quarter infused by the intramammary route to the untreated quarters was also studied. ..
  2. Bartlett M, Shaw M, Smith J, Meshnick S. Efficacy of sulfamethoxypyridazine in a murine model of Pneumocystis carinii pneumonia. Antimicrob Agents Chemother. 1998;42:934-5 pubmed
    ..b>Sulfamethoxypyridazine is significantly more effective than sulfamethoxazole against a murine model of P...
  3. Hughes W, Killmar J. Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia. Antimicrob Agents Chemother. 1996;40:962-5 pubmed
    ..0 mg of sulfamethoxazole, sulfamethoxypyridazine, and sulfadimethoxine per kg per day, as little as 10 mg of sulfameter, sulfachlorpyridazine, and ..
  4. Escalera J, Bustamante P, Martin A. Predicting the solubility of drugs in solvent mixtures: multiple solubility maxima and the chameleonic effect. J Pharm Pharmacol. 1994;46:172-6 pubmed
    ..These results show that the chameleonic effect can be described in a quantitative way in terms of Lewis acid-base interactions; this approach can assist the product formulator to choose the proper solvent mixture for a new drug. ..
  5. Qin Y, Zhang M, Lin H. [Qualification and quantification of 10 sulfonamides in animal feedstuff by high performance liquid chromatography-electrospray tandem mass spectrometry]. Se Pu. 2005;23:397-400 pubmed
    ..sulfadiazine (SD), sulfapyridine (SPD), sulfamerazine (SM1), sulfameter (SM), sulfamethazine (SM2), sulfamethoxypyridazine (SMP), sulfamethoxazole (SMZ), sulfamonomethoxine (SMM), sulfadimethoxine (SDM) and sulfaquinoxaline (SQX)...
  6. McFadden J, Leonard J, Powles A, Rutman A, Fry L. Sulphamethoxypyridazine for dermatitis herpetiformis, linear IgA disease and cicatricial pemphigoid. Br J Dermatol. 1989;121:759-62 pubmed
  7. Sakharov I, Berlina A, Zherdev A, Dzantiev B. Advantages of soybean peroxidase over horseradish peroxidase as the enzyme label in chemiluminescent enzyme-linked immunosorbent assay of sulfamethoxypyridazine. J Agric Food Chem. 2010;58:3284-9 pubmed publisher
    An indirect competitive chemiluminescent enzyme-linked immunosorbent assay (CL-ELISA) of sulfamethoxypyridazine (SMP) was developed...
  8. Khaleel N, Mahmoud W, Hadad G, Abdel Salam R, Kümmerer K. Photolysis of sulfamethoxypyridazine in various aqueous media: aerobic biodegradation and identification of photoproducts by LC-UV-MS/MS. J Hazard Mater. 2013;244-245:654-61 pubmed publisher
    ..The photolysis of sulfamethoxypyridazine (SMP) using a medium pressure Hg-lamp was evaluated in three different media: Millipore water pH 6...
  9. Yang L, Shi Y, Li J, Fang L, Luan T. Transformation of aqueous sulfonamides under horseradish peroxidase and characterization of sulfur dioxide extrusion products from sulfadiazine. Chemosphere. 2018;200:164-172 pubmed publisher
    ..SMX), sulfathiazole (STZ), sulfapyridine (SPD), sulfadiazine (SDZ), sulfamerazine (SMR) and sulfamethoxypyridazine (SMP) were selected as target compounds...
  10. Bustamante P, Escalera B, Martin A, Selles E. Predicting the solubility of sulfamethoxypyridazine in individual solvents. I: Calculating partial solubility parameters. J Pharm Sci. 1989;78:567-73 pubmed
    b>Sulfamethoxypyridazine, a representative model of a drug molecule, is used to test the extended Hansen method for estimating partial solubility parameters of solid compounds. Solubilities are determined in polar and nonpolar solvents...
  11. Roudaut B, Moretain J. Sulphonamide residues in milk of dairy cows following intravenous injection. Food Addit Contam. 1990;7:527-33 pubmed
    ..01 micrograms/ml. These results were used to determine the withdrawal times (two to six milkings) required for these drugs with a tolerance of 0.1 micrograms/ml as proposed by the European countries. ..
  12. Gach J, Wilson N, Wojnarowska F, Ilchyshyn A. Sulfamethoxypyridazine-responsive pemphigoid nodularis: a report of two cases. J Am Acad Dermatol. 2005;53:S101-4 pubmed
    ..We describe two cases of pemphigoid nodularis treated successfully with sulfamethoxypyridazine without any adverse effects.
  13. Zhou D, Thiele Bruhn S, Arenz Leufen M, Jacques D, Lichtner P, Engelhardt I. Impact of manure-related DOM on sulfonamide transport in arable soils. J Contam Hydrol. 2016;192:118-128 pubmed publisher
    ..Transport of three SAs, sulfadiazine (SDZ), sulfamethoxypyridazine (SMPD), and sulfamoxole (SMOX), was investigated in saturated soil columns with and without manure ..
  14. Steinfort C, Wiggins J, Sheffield E, Keal E. Alveolitis associated with sulphamethoxypyridazine. Thorax. 1989;44:310-1 pubmed
    ..A woman developed alveolitis which appeared to be caused by sulphamethoxypyridazine and which resolved after withdrawal of the drug and six months' treatment with prednisolone. ..
  15. Garg S, Uppal R, Riviere J. Serum disappearance and urinary excretion of sulfamethoxypyridazine in goats. Rev Elev Med Vet Pays Trop. 1994;47:215-8 pubmed
    Pharmacokinetics and urinary excretion of sulfamethoxypyridazine were determined in goats following single intravenous administration (100 mg/kg body weight)...
  16. Berlina A, Zherdev A, Dzantiev B, Sakharov I. [Use of soybean peroxidase for the enzyme immunoassay of sulfamethoxipyridazine in milk]. Prikl Biokhim Mikrobiol. 2007;43:614-20 pubmed
    ..The results obtained demonstrate that the assay developed is promising, displaying a sensitivity that exceeds the maximum permissible concentration of sulfamides in milk (100 microg/l) by several orders of magnitude. ..
  17. Sun H, Pan Y, Gu Y, Lin Z. Mechanistic explanation of time-dependent cross-phenomenon based on quorum sensing: A case study of the mixture of sulfonamide and quorum sensing inhibitor to bioluminescence of Aliivibrio fischeri. Sci Total Environ. 2018;630:11-19 pubmed publisher
    ..cross-phenomenon was observed, in which the cross-concentration range between the CRC for the mixture of sulfamethoxypyridazine (SMP) and (Z-)-4-Bromo-5-(bromomethylene)-2(5H)-furanone (C30) to the bioluminescence of Aliivibrio ..
  18. Shah S, Hao C. Quantum chemical investigation on photodegradation mechanisms of sulfamethoxypyridazine with dissolved inorganic matter and hydroxyl radical. J Environ Sci (China). 2017;57:85-92 pubmed publisher
    b>Sulfamethoxypyridazine (SMP) is one of the commonly used sulfonamide antibiotics (SAs)...
  19. Jia A, Hu J, Wu X, Peng H, Wu S, Dong Z. Occurrence and source apportionment of sulfonamides and their metabolites in Liaodong Bay and the adjacent Liao River basin, North China. Environ Toxicol Chem. 2011;30:1252-60 pubmed publisher
    ..sulfamonomethoxine, sulfamethazine, sulfaquinoxaline, sulfaguanidine, sulfadiazine, sulfanilamide, and sulfamethoxypyridazine were dominant in the animal husbandry sources, specifically, swine and poultry farms, and sulfamethoxazole ..
  20. Bustamante P, Martin A, Gonzalez Guisandez M. Partial solubility parameters and solvatochromic parameters for predicting the solubility of single and multiple drugs in individual solvents. J Pharm Sci. 1993;82:635-40 pubmed
    ..Furthermore, a number of drugs (e.g., sulfadiazine, sulfamethoxypyridazine, naphthalene, and some benzoic acid derivatives) are combined in a single expression including the ideal ..
  21. Giordano F, La Manna A, Bettinetti G, Zamparutti M. Preformulation studies on suppositories by thermal methods. Boll Chim Farm. 1990;129:160-5 pubmed
    ..scanning calorimetry (DSC) is described for investigating the interaction between trimethoprim and sulfamethoxypyridazine in suppository formulations containing fat bases (Suppocire, Novata, Witepsol)...
  22. Martin A, Bustamante P, Escalera B, Selles E. Predicting the solubility of sulfamethoxypyridazine in individual solvents. II: Relationship between solute-solvent interaction terms and partial solubility parameters. J Pharm Sci. 1989;78:672-8 pubmed
    ..The solubility of sulfamethoxypyridazine in 30 solvents is used to test the semiempirical solubility equations...
  23. Iglesias A, Nebot C, Miranda J, Vázquez B, Abuín C, Cepeda A. Determination of the Presence of Three Antimicrobials in Surface Water Collected from Urban and Rural Areas. Antibiotics (Basel). 2013;2:46-57 pubmed publisher
    ..into the environment, the aim of this study was to compare the frequency of detection of sulfamethazine, sulfamethoxypyridazine and trimethoprim in surface water collected from urban and rural areas in Northwestern Spain...
  24. Wu Y, Zhao L, Liu Y, Jiang Y, Liu X, Shen J. [Simultaneous determination of nine sulfonamide residues in milk using solid phase extraction and high performance liquid chromatography]. Se Pu. 2007;25:728-31 pubmed
    ..the simultaneous determination of nine sulfonamides (SAs) (sulfadiazine, sulfathiazole, sulfamethazine, sulfamethoxypyridazine, sufamonomethoxine, sulfachloropyridazine, sulfamethoxazole, sulfadimethoxine and sulfaquinoxaline) in ..
  25. Tolmacheva V, Apyari V, Furletov A, Dmitrienko S, Zolotov Y. Facile synthesis of magnetic hypercrosslinked polystyrene and its application in the magnetic solid-phase extraction of sulfonamides from water and milk samples before their HPLC determination. Talanta. 2016;152:203-10 pubmed publisher
    ..hypercrosslinked polystyrene (HCP/Fe3O4), was prepared and used for preconcentration of four sulfonamides (sulfamethoxypyridazine, sulfamethazine, sulfamethoxazole and sulfachloropyridazine) from natural water and milk samples...
  26. Bustamante P, Escalera B. Enthalpy and entropy contributions to the solubility of sulphamethoxypyridazine in solvent mixtures showing two solubility maxima. J Pharm Pharmacol. 1995;47:550-5 pubmed
    ..The two solvent systems show enthalpy-entropy compensation. Water deviates from the linear relationship due possibly to its hydrophobic effect. ..
  27. Ye S, Yao Z, Na G, Wang J, Ma D. Rapid simultaneous determination of 14 sulfonamides in wastewater by liquid chromatography tandem mass spectrometry. J Sep Sci. 2007;30:2360-9 pubmed
    ..Sulfamethazine (SM(2)), sulfamethoxypyridazine (SMP), and sulfamethoxazole (SMZ) were most frequently found in wastewater in a concentration range ..
  28. Bettinetti G, Caira M, Callegari A, Merli M, Sorrenti M, Tadini C. Structure and solid-state chemistry of anhydrous and hydrated crystal forms of the trimethoprim-sulfamethoxypyridazine 1:1 molecular complex. J Pharm Sci. 2000;89:478-89 pubmed
    The crystal structure of the equimolar trimethoprim (TMP) and sulfamethoxypyridazine (SMPD) complex in the anhydrous form (TMP. SMPD) and that of the species with 1.5 molecules of water of crystallization (TMP.SMPD...
  29. Thornhill M, Pemberton M, Buchanan J, Theaker E. An open clinical trial of sulphamethoxypyridazine in the treatment of mucous membrane pemphigoid. Br J Dermatol. 2000;143:117-26 pubmed
    ..The results indicate that with appropriate monitoring SMXP is an effective treatment for MMP and compares favourably with other systemic agents used in the management of this condition. ..
  30. Chorzelski T, Stefanato C, Stanley J, Beutner E, Korman N, Olszewska M, et al. Erythema annulare-like acantholytic dermatosis (EAAD): nonbullous pemphigus or a new entity?. Am J Med Sci. 1993;306:145-50 pubmed
    ..It is to be established whether such cases present a new type of pemphigus or a unknown dermatosis with an autoimmune response of a pemphigus type. ..
  31. Murgia S, Del Curto E, Zecca G. [Benign intracranial hypertension caused by sulfenazone]. Pediatr Med Chir. 1989;11:541-2 pubmed
    ..Having ruled out other specific acute diseases of the central nervous system, it seems reasonable not to start any treatment since the outcome of this condition is always benign. ..
  32. Liu A, Dong L, Wei X, Yang X, Xiao J, Liu Z. Development of amino- and dimethylcarbamate-substituted resorcinol as programmed cell death-1 (PD-1) inhibitor. Eur J Pharm Sci. 2016;88:50-8 pubmed publisher
    ..moiety or a nitro at resorcinol skeleton enhanced the inhibitory effect of AAPD even higher than that of sulfamethoxypyridazine, another successful PD-1 inhibitor...
  33. Mützell S. Computed tomography of the brain, hepatotoxic drugs and high alcohol consumption in male alcoholic patients and a random sample from the general male population. Ups J Med Sci. 1992;97:183-94 pubmed