sulfadiazine

Summary

Summary: One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.

Top Publications

  1. Ollivier J, Kleineidam K, Reichel R, Thiele Bruhn S, Kotzerke A, Kindler R, et al. Effect of sulfadiazine-contaminated pig manure on the abundances of genes and transcripts involved in nitrogen transformation in the root-rhizosphere complexes of maize and clover. Appl Environ Microbiol. 2010;76:7903-9 pubmed publisher
    The antibiotic sulfadiazine (SDZ) can enter the environment by application of manure from antibiotic-treated animals to arable soil...
  2. Lam S, Tessler H. Quadruple therapy for ocular toxoplasmosis. Can J Ophthalmol. 1993;28:58-61 pubmed
    ..The length of follow-up ranged from 1 month to 15.5 years. There were seven recurrences in five patients, five of which responded to a second course of quadruple therapy...
  3. Jechalke S, Kopmann C, Richter M, Moenickes S, Heuer H, Smalla K. Plasmid-mediated fitness advantage of Acinetobacter baylyi in sulfadiazine-polluted soil. FEMS Microbiol Lett. 2013;348:127-32 pubmed publisher
    ..of Acinetobacter baylyi BD413 in soil after application of manure with or without the sulfonamide antibiotic sulfadiazine (SDZ). The persistence of A...
  4. Kopmann C, Jechalke S, Rosendahl I, Groeneweg J, Krögerrecklenfort E, Zimmerling U, et al. Abundance and transferability of antibiotic resistance as related to the fate of sulfadiazine in maize rhizosphere and bulk soil. FEMS Microbiol Ecol. 2013;83:125-34 pubmed publisher
    ..The fate of sulfadiazine (SDZ) introduced via manure and its effect on resistance gene levels in the rhizosphere were compared with that ..
  5. Soheilian M, Ramezani A, Azimzadeh A, Sadoughi M, Dehghan M, Shahghadami R, et al. Randomized trial of intravitreal clindamycin and dexamethasone versus pyrimethamine, sulfadiazine, and prednisolone in treatment of ocular toxoplasmosis. Ophthalmology. 2011;118:134-41 pubmed publisher
    ..clindamycin and 400 ?g dexamethasone, and the CT group received 6 weeks of treatment with pyrimethamine and sulfadiazine plus prednisolone...
  6. Lamshöft M, Sukul P, Zühlke S, Spiteller M. Behaviour of (14)C-sulfadiazine and (14)C-difloxacin during manure storage. Sci Total Environ. 2010;408:1563-8 pubmed publisher
    The persistence of sulfadiazine, difloxacin, and their metabolites has been investigated in stored manure...
  7. de Araujo M, Vieira E, Silva Lázaro G, Conegero L, Almeida L, Barreto L, et al. Sulfadiazine/hydroxypropyl-beta-cyclodextrin host-guest system: Characterization, phase-solubility and molecular modeling. Bioorg Med Chem. 2008;16:5788-94 pubmed publisher
    In this work we prepared and characterized an inclusion complex of the dihydropteroate synthase inhibitor sulfadiazine (SDZ) in 2-hydroxypropyl-beta-cyclodextrin (HPBCD)...
  8. Soheilian M, Sadoughi M, Ghajarnia M, Dehghan M, Yazdani S, Behboudi H, et al. Prospective randomized trial of trimethoprim/sulfamethoxazole versus pyrimethamine and sulfadiazine in the treatment of ocular toxoplasmosis. Ophthalmology. 2005;112:1876-82 pubmed
    To compare the efficacy of the classic treatment of ocular toxoplasmosis (pyrimethamine, sulfadiazine, and prednisolone) with a regimen consisting of trimethoprim/sulfamethoxazole (co-trimoxazole) plus prednisolone.
  9. Schmidt D, Hogh B, Andersen O, Hansen S, Dalhoff K, Petersen E. Treatment of infants with congenital toxoplasmosis: tolerability and plasma concentrations of sulfadiazine and pyrimethamine. Eur J Pediatr. 2006;165:19-25 pubmed
    The aim was to study the tolerability and plasma concentrations of pyrimethamine and sulfadiazine in children treated for congenital toxoplasmosis...

More Information

Publications62

  1. Doliwa C, Escotte Binet S, Aubert D, Velard F, Schmid A, Geers R, et al. Induction of sulfadiazine resistance in vitro in Toxoplasma gondii. Exp Parasitol. 2013;133:131-6 pubmed publisher
    We induced sulfadiazine resistance in two sulfadiazine sensitive strains of Toxoplasma gondii, RH (Type I) and ME-49 (Type II) in vitro by using drug pressure...
  2. Costa I, Angeloni M, Santana L, Barbosa B, Silva M, Rodrigues A, et al. Azithromycin inhibits vertical transmission of Toxoplasma gondii in Calomys callosus (Rodentia: Cricetidae). Placenta. 2009;30:884-90 pubmed publisher
    ..In conclusion, the treatment with azithromycin showed to be more effective, since it was capable to inhibit the vertical transmission of T. gondii in this model of congenital toxoplasmosis. ..
  3. Kotzerke A, Sharma S, Schauss K, Heuer H, Thiele Bruhn S, Smalla K, et al. Alterations in soil microbial activity and N-transformation processes due to sulfadiazine loads in pig-manure. Environ Pollut. 2008;153:315-22 pubmed
    ..of the present study to investigate the effects of manure containing different concentrations of the antibiotic sulfadiazine (SDZ) on the soil microbial communities...
  4. Modak S, Fox C. Binding of silver sulfadiazine to the cellular components of Pseudomonas aeruginosa. Biochem Pharmacol. 1973;22:2391-404 pubmed
  5. Podzamczer D, Miro J, Ferrer E, Gatell J, Ramon J, Ribera E, et al. Thrice-weekly sulfadiazine-pyrimethamine for maintenance therapy of toxoplasmic encephalitis in HIV-infected patients. Spanish Toxoplasmosis Study Group. Eur J Clin Microbiol Infect Dis. 2000;19:89-95 pubmed
    ..randomised, multicentre trial was conducted to evaluate the efficacy of thrice-weekly versus daily therapy with sulfadiazine-pyrimethamine in the prevention of relapses of toxoplasmic encephalitis in HIV-infected patients...
  6. Bosch Driessen L, Verbraak F, Suttorp Schulten M, van Ruyven R, Klok A, Hoyng C, et al. A prospective, randomized trial of pyrimethamine and azithromycin vs pyrimethamine and sulfadiazine for the treatment of ocular toxoplasmosis. Am J Ophthalmol. 2002;134:34-40 pubmed
    ..To compare the effects of two treatment regimens, one of which included azithromycin, for the treatment of sight-threatening (near optic disk or fovea) ocular toxoplasmosis...
  7. Jechalke S, Kopmann C, Rosendahl I, Groeneweg J, Weichelt V, Krögerrecklenfort E, et al. Increased abundance and transferability of resistance genes after field application of manure from sulfadiazine-treated pigs. Appl Environ Microbiol. 2013;79:1704-11 pubmed publisher
    ..In this study, the effects of manure from pigs treated with sulfadiazine (SDZ), here called SDZ manure, on the abundance and transferability of sulfonamide resistance genes sul1 and ..
  8. Holland G. Ocular toxoplasmosis: a global reassessment. Part II: disease manifestations and management. Am J Ophthalmol. 2004;137:1-17 pubmed
    ..To update clinical information about ocular toxoplasmosis. Part II reviews the spectrum of disease manifestations and factors that influence severity of disease. Implications for disease management are discussed...
  9. Petersen E, Schmidt D. Sulfadiazine and pyrimethamine in the postnatal treatment of congenital toxoplasmosis: what are the options?. Expert Rev Anti Infect Ther. 2003;1:175-82 pubmed
    ..Postpartum treatment of congenital toxoplasmosis with sulfadiazine and pyrimethamine has remained almost unchanged for 50 years...
  10. Khachatryan A, Besser T, Call D. The streptomycin-sulfadiazine-tetracycline antimicrobial resistance element of calf-adapted Escherichia coli is widely distributed among isolates from Washington state cattle. Appl Environ Microbiol. 2008;74:391-5 pubmed publisher
    ..we demonstrated that Escherichia coli strains with a specific resistance pattern (resistant to streptomycin, sulfadiazine, and tetracycline [SSuT]) have a selective advantage in dairy calf intestinal environments and in the presence ..
  11. Seijo Martinez M, Gonzalez Mediero G, Santiago P, Rodriguez De Lope A, Diz J, Conde C, et al. Granulomatous amebic encephalitis in a patient with AIDS: isolation of acanthamoeba sp. Group II from brain tissue and successful treatment with sulfadiazine and fluconazole. J Clin Microbiol. 2000;38:3892-5 pubmed
    ..The patient was treated with fluconazole and sulfadiazine, and the lesion was surgically excised...
  12. Balaskas K, Vaudaux J, Boillat Blanco N, Guex Crosier Y. Azithromycin versus Sulfadiazine and Pyrimethamine for non-vision-threatening toxoplasmic retinochoroiditis: a pilot study. Med Sci Monit. 2012;18:CR296-302 pubmed
    ..study is to compare the efficacy and tolerance of azithromycin alone as opposed to standard treatment with sulfadiazine and pyrimethamine for active, non-vision-threatening toxoplasmic retinochoroiditis...
  13. Rosendahl I, Siemens J, Groeneweg J, Linzbach E, Laabs V, Herrmann C, et al. Dissipation and sequestration of the veterinary antibiotic sulfadiazine and its metabolites under field conditions. Environ Sci Technol. 2011;45:5216-22 pubmed publisher
    ..We examined the dissipation and sequestration of sulfadiazine (SDZ) and its main metabolites in soil under field conditions and how it was influenced by temperature, soil ..
  14. Tappe W, Herbst M, Hofmann D, Koeppchen S, Kummer S, Thiele B, et al. Degradation of sulfadiazine by Microbacterium lacus strain SDZm4, isolated from lysimeters previously manured with slurry from sulfadiazine-medicated pigs. Appl Environ Microbiol. 2013;79:2572-7 pubmed publisher
    b>Sulfadiazine (SDZ)-degrading bacterial cultures were enriched from the topsoil layer of lysimeters that were formerly treated with manure from pigs medicated with (14)C-labeled SDZ...
  15. Heuer H, Smalla K. Manure and sulfadiazine synergistically increased bacterial antibiotic resistance in soil over at least two months. Environ Microbiol. 2007;9:657-66 pubmed
    ..We investigated effects of pig manure and sulfadiazine (SDZ) on bacterial communities in soil microcosms...
  16. McLeod R, Khan A, Noble G, Latkany P, Jalbrzikowski J, Boyer K. Severe sulfadiazine hypersensitivity in a child with reactivated congenital toxoplasmic chorioretinitis. Pediatr Infect Dis J. 2006;25:270-2 pubmed
    A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after ..
  17. Holland G. Prospective, randomized trial of trimethoprim/sulfamethoxazole vs. pyrimethamine and sulfadiazine in the treatment of ocular toxoplasmosis: discussion. Ophthalmology. 2005;112:1882-4 pubmed
  18. Krátký M, Dzurková M, Janousek J, Konecna K, Trejtnar F, Stolarikova J, et al. Sulfadiazine Salicylaldehyde-Based Schiff Bases: Synthesis, Antimicrobial Activity and Cytotoxicity. Molecules. 2017;22: pubmed publisher
    ..Thus, we synthesized a series of Schiff bases derived from the sulfa drug sulfadiazine and various salicylaldehydes...
  19. Rajkhowa S, Sarma D, Pegu S. SCC mec typing and antimicrobial resistance of methicillin-resistant Staphylococcus aureus (MRSA) from pigs of Northeast India. Vet Res Commun. 2016;40:117-122 pubmed
    ..The most predominant resistance pattern observed was Oxytetracycline + Penicillin + Sulfadiazine + Tetracycline accounting 12.24 % of the isolates...
  20. Chen Y, Zhang H, Luo Y, Hu G, Zhao Y, Song J. [Investigation of 14 selected antibiotics in sediments of the typical cross sections of Tiaoxi River]. Huan Jing Ke Xue. 2011;32:667-72 pubmed
    ..14 antibiotics includes tetracycline (TC), oxytetracycline (OTC), chlortetracycline (CTC), doxycycline (DXC), sulfadiazine (SD), sulfamethoxazole (SMZ), sulfamethazine (SMX), norfloxacin (NFC), ofloxacin (OFC), enythromycin-H2O (ETM-..
  21. Arens J, Barnes K, Crowley N, Maartens G. Treating AIDS-associated cerebral toxoplasmosis - pyrimethamine plus sulfadiazine compared with cotrimoxazole, and outcome with adjunctive glucocorticoids. S Afr Med J. 2007;97:956-8 pubmed
    ..Eighteen patients received pyrimethamine plus sulfadiazine and 25 co-trimoxazole, with comparable baseline characteristics...
  22. Yu Z, He P, Shao L, Zhang H, Lu F. Co-occurrence of mobile genetic elements and antibiotic resistance genes in municipal solid waste landfill leachates: A preliminary insight into the role of landfill age. Water Res. 2016;106:583-592 pubmed publisher
    ..Seven sulfonamides (sulfapyridine, sulfadiazine, sulfathiazole, sulfamethoxazole, sulfamerazine, sulfamethazine and sulfaquinoxaline), three encoded ARGs (sul-..
  23. Theunissen D, Seymour B, Forder M, Cox S, Rode H. Measurements in wound healing with observations on the effects of topical agents on full thickness dermal incised wounds. Burns. 2016;42:556-63 pubmed publisher
    ..Topical agents improve all aspects of wound healing. The addition of a human recombinant EGF to Silver-Sulphadiazine increases epithelial growth and amounts of collagen in the regenerating wounds at day 7. ..
  24. Vincent Johnson N. Questions limitation in treatment of hepatozoonosis. J Am Vet Med Assoc. 2005;226:1979 pubmed
  25. Forget S, Avances C, Dubon O, Mares P, Costa P. [Calculous renal failure and pregnancy]. Prog Urol. 2003;13:673-4 pubmed
    ..are due to extrinsic compression, renal tract obstruction can also be due to intraluminal precipitation of sulfadiazine prescribed for maternofoetal toxoplasmosis...
  26. Harris C, Salgo M, Tanowitz H, Wittner M. In vitro assessment of antimicrobial agents against Toxoplasma gondii. J Infect Dis. 1988;157:14-22 pubmed
    ..1 microgram/ml) and sulfadiazine (25 micrograms/ml) are synergistic. Pyrimethamine at higher concentrations (0.5 and 1...
  27. Tong L, Qin L, Xie C, Liu H, Wang Y, Guan C, et al. Distribution of antibiotics in alluvial sediment near animal breeding areas at the Jianghan Plain, Central China. Chemosphere. 2017;186:100-107 pubmed publisher
    ..None of the compounds were detected in the deep layer at 20 m but for sulfadiazine and chlorotetracycline...
  28. Wolters A, Steffens M. Photodegradation of antibiotics on soil surfaces: laboratory studies on sulfadiazine in an ozone-controlled environment. Environ Sci Technol. 2005;39:6071-8 pubmed
    ..For studying various photochemical transformation processes of sulfadiazine, a photovolatility chamber designed in accordance with the requirements of the USEPA Guideline and 161-3 was ..
  29. Albala D, Prien E, Galal H. Urolithiasis as a hazard of sulfonamide therapy. J Endourol. 1994;8:401-3 pubmed
    ..men and 15 women) who developed calculi composed totally or partially of sulfonamides (acetylsulfamethoxazole, sulfadiazine, and acetylsulfisoxazole) between 1980 and 1987. The incidence of sulfonamide stones is less than 1% of stones...
  30. Pelloux H, Fricker Hidalgo H, Pons J, Bost Bru C, Brenier Pinchart M, Jouk P, et al. [Congenital toxoplasmosis: prevention in the pregnant woman and management of the neonate]. Arch Pediatr. 2002;9:206-12 pubmed
    ..After birth, the follow-up of the child is needed in order to prevent and detect the sequellae, mainly ocular. For all these steps, the biological methods used to diagnose T. gondii infection are of paramount importance. ..
  31. Wang Z, Du Y, Yang C, Liu X, Zhang J, Li E, et al. Occurrence and ecological hazard assessment of selected antibiotics in the surface waters in and around Lake Honghu, China. Sci Total Environ. 2017;609:1423-1432 pubmed publisher
    ..Tetracycline, oxytetracycline, chlortetracycline, and sulfadiazine are the four dominant antibiotics in this region, with maximum and median concentrations of 1454.8 and 304...
  32. Allinson J, Topping W, Edwards S, Miller R. Sulphadiazine-induced obstructive renal failure complicating treatment of HIV-associated toxoplasmosis. Int J STD AIDS. 2012;23:210-2 pubmed publisher
    ..This case serves to remind clinicians of the need for vigilance when treating cerebral toxoplasmosis with sulphadiazine, in order to avoid this potentially serious complication of treatment. ..
  33. Zacharevskij E, Baranauskas G, Varkalys K, Rimdeika R, Kubilius D. Comparison of non-surgical methods for the treatment of deep partial thickness skin burns of the hand. Burns. 2018;44:445-452 pubmed publisher
    ..dressings; treated with mechanical debridement of monofilament polyester fibers pad and then applying silver sulfadiazine; treated with gauze dressings containing enzymatic collagenase preparation...
  34. Oliveira C, Meurer Y, Andrade J, Costa M, Andrade M, Silva L, et al. Pathogenicity and phenotypic sulfadiazine resistance of Toxoplasma gondii isolates obtained from livestock in northeastern Brazil. Mem Inst Oswaldo Cruz. 2016;111:391-8 pubmed publisher
    ..Our study aimed to differentiate the pathogenicity and sulfadiazine resistance of three T. gondii isolates obtained from livestock intended for human consumption...
  35. Mohiti Asli M, Risselada M, JACOB M, Pourdeyhimi B, Loboa E. Creation and Evaluation of New Porcine Model for Investigation of Treatments of Surgical Site Infection. Tissue Eng Part C Methods. 2017;23:795-803 pubmed publisher
    ..inoculated with MRSA relative to nontreated controls and to wounds treated with the gold standard, silver sulfadiazine, without causing inflammation at the wound site...
  36. Lopes C, Silva N, Ferro E, Sousa R, Firminot M, Bernardes E, et al. Azithromycin reduces ocular infection during congenital transmission of toxoplasmosis in the Calomys callosus model. J Parasitol. 2009;95:1005-10 pubmed publisher
    ..The most widely used treatment for acute toxoplasmosis during pregnancy is pyrimethamine plus sulfadiazine, which has several side effects...
  37. Shah V, Gurbarg M, Noory A, Dighe S, Skelly J. Influence of higher rates of agitation on release patterns of immediate-release drug products. J Pharm Sci. 1992;81:500-3 pubmed
    ..of chloroquine phosphate, griseofulvin, hydroxychloroquine sulfate, isocarboxazide, primaquine phosphate, and sulfadiazine. Each of these products has a USP monograph requiring a dissolution test at a paddle speed of 100 rpm...
  38. Van den Meersche T, Van Pamel E, Van Poucke C, Herman L, Heyndrickx M, Rasschaert G, et al. Development, validation and application of an ultra high performance liquid chromatographic-tandem mass spectrometric method for the simultaneous detection and quantification of five different classes of veterinary antibiotics in swine manure. J Chromatogr A. 2016;1429:248-57 pubmed publisher
    ..mass spectrometric (UHPLC-MS/MS) method for the simultaneous detection and quantification of colistin, sulfadiazine, trimethoprim, doxycycline, oxytetracycline and ceftiofur and for the detection of tylosin A in swine manure ..
  39. Agustín A, Carramiñana J, Rota C, Herrera A. Antimicrobial resistance of Salmonella spp. from pigs at slaughter in Spain in 1993 and 2001. Lett Appl Microbiol. 2005;41:39-44 pubmed
    ..Data showed that the majority of the strains were resistant to streptomycin (97%), sulfadiazine (93.4%) and tetracycline (83.3%)...
  40. Huertas Pérez J, Arroyo Manzanares N, Havlíková L, Gámiz Gracia L, Solich P, García Campaña A. Method optimization and validation for the determination of eight sulfonamides in chicken muscle and eggs by modified QuEChERS and liquid chromatography with fluorescence detection. J Pharm Biomed Anal. 2016;124:261-266 pubmed publisher
    A simple, effective and reliable method for the determination of eight sulfonamide antibiotics (sulfadiazine, sulfapiridine, sulfamerazine, sulfamethazine, sulfachloropiridazine, sulfamethoxazole, sulfadoxine, sulfadimethoxin) in chicken ..
  41. Stephens R, Mythen M, Kallis P, Davies D, Egner W, Rickards A. Two episodes of life-threatening anaphylaxis in the same patient to a chlorhexidine-sulphadiazine-coated central venous catheter. Br J Anaesth. 2001;87:306-8 pubmed
    ..We describe what we believe is the first reported case of anaphylaxis in a European patient to a chlorhexidine- sulphadiazine-coated central venous catheter. ..
  42. Piercy R, Hinchcliff K, Reed S. Folate deficiency during treatment with orally administered folic acid, sulphadiazine and pyrimethamine in a horse with suspected equine protozoal myeloencephalitis (EPM). Equine Vet J. 2002;34:311-6 pubmed
  43. Bergsjø T, Nafstad I, Ingebrigtsen K. The distribution of 35S-sulfadiazine and 14C-trimethoprim in rainbow trout, Salmo gairdneri. Acta Vet Scand. 1979;20:25-37 pubmed
  44. Macintire D, Vincent Johnson N, Kane C, Lindsay D, Blagburn B, Dillon A. Treatment of dogs infected with Hepatozoon americanum: 53 cases (1989-1998). J Am Vet Med Assoc. 2001;218:77-82 pubmed
    ..Dogs were treated with various drugs, including toltrazuril, trimethoprim-sulfadiazine, clindamycin, pyrimethamine, and decoquinate...
  45. Lu F, Li H, Sun M, Fan L, Qiu H, Li X, et al. Flow injection chemiluminescence sensor based on core-shell magnetic molecularly imprinted nanoparticles for determination of sulfadiazine. Anal Chim Acta. 2012;718:84-91 pubmed publisher
    A novel flow injection chemiluminescence (FI-CL) sensor for determination of sulfadiazine (SDZ) using core-shell magnetic molecularly imprinted polymers (MMIPs) as recognition element is developed...
  46. Beltrame A, Venturini S, Crichiutti G, Meroni V, Buonfrate D, Bassetti M. Recurrent seizures during acute acquired toxoplasmosis in an immunocompetent traveller returning from Africa. Infection. 2016;44:259-62 pubmed publisher
    ..He was treated with pyrimethamine plus sulfadiazine and leucovorin for 4 weeks, with an improvement of lymphadenitis and normalization of EEG...
  47. Noda Y, Watanabe K, Sanagawa A, Sobajima Y, Fujii S. Physicochemical properties of macrogol ointment and emulsion ointment blend developed for regulation of water absorption. Int J Pharm. 2011;419:131-6 pubmed publisher
    ..LY-SL blended ointment consisted of lysozyme hydrochloride water-in-oil (w/o) emulsion (LY-cream) and sulfadiazine macrogol (polyethylene glycol) ointment (SL-pasta)...
  48. Oksi J, Toivanen A, Lammintausta K, Talve L. [Bothersome nodules on the fingers of a musician]. Duodecim. 2003;119:645-7 pubmed
  49. Bouzid F, Astier H, Osman D, Javelle E, Hassan M, Simon F, et al. Extended spectrum of antibiotic susceptibility for tuberculosis, Djibouti. Int J Antimicrob Agents. 2018;51:235-238 pubmed publisher
    ..to standard anti-tuberculous antibiotics in addition to clofazimine, minocycline, chloramphenicol and sulfadiazine. Among the 118 mycobacteria isolates from 118 successive patients with suspected pulmonary tuberculosis, 111 ..
  50. Donati L, Periti P, Andreassi A, Dioguardi D, Gliori A, Landi G, et al. Increased burn patient survival with once-a-day high dose teicoplanin and netilmicin. An Italian multicenter study. J Chemother. 1998;10:47-57 pubmed
    ..The antibiotic treatment of burn patients consisted of topical silver sulfadiazine, short-term antimicrobial chemoprophylaxis with pefloxacin (800 mg i.v...
  51. Lindsay D, Dubey J. Effects of sulfadiazine and amprolium on Neospora caninum (Protozoa: Apicomplexa) infections in mice. J Parasitol. 1990;76:177-9 pubmed
    An immunosuppressed mouse model was used to determine the effects of amprolium and sulfadiazine on experimental Neospora caninum infections. Both drugs were given in the drinking water...
  52. Yilmaz V, Icsel C, Batur J, Aydinlik S, Sahinturk P, Aygün M. Structures and biochemical evaluation of silver(I) 5,5-diethylbarbiturate complexes with bis(diphenylphosphino)alkanes as potential antimicrobial and anticancer agents. Eur J Med Chem. 2017;139:901-916 pubmed publisher
    ..Gram-negative bacteria, but 2 targets both bacterial strains, being comparable to AgNO3 and silver sulfadiazine. Complex 1 has a strong growth inhibitory effect on A549 cells, while 2 and 3 exhibit considerable ..
  53. Alves C, Vitor R. Efficacy of atovaquone and sulfadiazine in the treatment of mice infected with Toxoplasma gondii strains isolated in Brazil. Parasite. 2005;12:171-7 pubmed
    The efficacy of atovaquone and sulfadiazine was examined alone or in combination for the treatment of mice infected with six Brazilian Toxoplasma gondii strains previously genotyped using the PCR-RFLP assays of the SAG2 gene, in addition ..