Summary: An anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections.

Top Publications

  1. Abramovits W, Kennedy A. Sulfur/sodium sulfacetamide preparations. Skinmed. 2004;3:95-101 pubmed
  2. Del Rosso J. Medical treatment of rosacea with emphasis on topical therapies. Expert Opin Pharmacother. 2004;5:5-13 pubmed
    ..The list of main topical agents utilised for the treatment of rosacea include metronidazole, sulfacetamide-sulfur, azelaic acid and topical antibiotics (clindamycin, erythromycin)...
  3. Xu S, Wu L. [Determination of sulfacetamide sodium and sulfanilamide in shao tang ling ointment by high performance liquid chromatography]. Se Pu. 1999;17:206-7 pubmed
    An HPLC method for the determination of sulfacetamide sodium and sulfanilamide in Shao Tang Ling ointment was developed. The chromatographic conditions were: column, Spherisorb C18, mobile phase, methanol-0...
  4. Gupta A, Nicol K. The use of sulfur in dermatology. J Drugs Dermatol. 2004;3:427-31 pubmed
    ..Sulfur, used alone or in combination with agents such as sodium sulfacetamide or salicylic acid, has demonstrated efficacy in the treatment of many dermatological conditions.
  5. Zhen Y, Stoudemayer M, Vamvakias G, Kligman A. Pilot investigation of the hydrating effects of topical acne medications. J Drugs Dermatol. 2007;6:810-6 pubmed
    ..with 1 of 4 topical therapies: 2 different (jar and tube) clindamycin 1%/benzoyl peroxide 5% gels, sodium sulfacetamide 10% lotion, or over-the-counter (OTC) moisturizing cream...
  6. Chen R, Yang Y, Qu B, Li Y, Lu Y, Tian L, et al. Rapid determination of sulfonamide residues in pork by surface-modified hydrophilic electrospun nanofibrous membrane solid-phase extraction combined with ultra-performance liquid chromatography. Anal Bioanal Chem. 2016;408:5499-511 pubmed publisher
    ..3-92.5 % with average RSDs (n = 6) of less than 15 % (except for sulfacetamide, 56.9-61.6 %)...
  7. Del Rosso J. Effectiveness and safety of doxycycline 40 mg (30-mg immediate-release and 10-mg delayed-release beads) once daily as add-on therapy to existing topical regimens for the treatment of papulopustular rosacea: results from a community-based trial. Cutis. 2010;86:16-25 pubmed
    ..papulopustular rosacea (PPR) who were receiving topical therapy (metronidazole, azelaic acid, and/ or sodium sulfacetamide-sulfur) at the time of the study entry but whose rosacea symptoms were still present...
  8. Pholpramool C, Verawatnapakul V, Ruchirawat S, Lewin L. Mode of action of the antifertility sulphonamides: lack of effects on folate metabolism. Contraception. 1990;42:667-75 pubmed
    ..The results suggest that the antifertility activity of sulphanilamide, sulphapyridine and perhaps some other sulphonamides is not associated with the inhibition of folate metabolism. ..
  9. Greiner J, Leahy C, Glonek T, Hearn S, Auerbach D, Davies L. Effects of eyelid scrubbing on the lid margin. CLAO J. 1999;25:109-13 pubmed
    ..Eyelid scrubbing was performed twice daily using ECS; ECS with the antibacterial sulfacetamide (ECS+); and ECS with sulfacetamide and prednisolone acetate (ECS++) over a 21 day period on three groups of 16 ..

More Information


  1. Parkin J. The decomposition of phenylmercuric nitrate in sulphacetamide drops during heat sterilization. J Pharm Pharmacol. 1993;45:1024-7 pubmed
    ..This loss occurs mainly due to the phenylmercuric ion establishing an equilibrium with equimolar amounts of mercuric ion and diphenylmercury. ..
  2. Izanloo M, Esrafili A, Behbahani M, Ghambarian M, Sobhi H. Trace quantification of selected sulfonamides in aqueous media by the implementation a new dispersive solid-phase extraction method using a nanomagnetic titanium dioxide graphene based sorbent and HPLC-UV. J Sep Sci. 2017;: pubmed publisher
    ..The method was proved to be simple, sensitive and highly efficient for the trace quantification of sulfacetamide, sulfathiazole, sulfamethoxazole and sulfadiazine in relatively large volume of aqueous media...
  3. Basrur V, Song Y, Mazur S, Higashimoto Y, Turpin J, Rice W, et al. Inactivation of HIV-1 nucleocapsid protein P7 by pyridinioalkanoyl thioesters. Characterization of reaction products and proposed mechanism of action. J Biol Chem. 2000;275:14890-7 pubmed
    ..determine the mechanism of modification of NCp7 by two lead compounds, N-[2-(5-pyridiniovaleroylthio)benzoyl]sulfacetamide bromide and N-[2-(5-pyridiniovaleroylthio)benzoyl]-4-(4-nitrophenylsulfonyl )anili ne bromide (compounds 45 ..
  4. Roth H, Leimbeck R, Sonnenschein B, Anger C, Weber S. [The effective antibacterial spectrum of sulfacetamide]. Klin Monbl Augenheilkd. 1992;200:182-6 pubmed
    ..independent microbiological institute in order to verify in-vitro antibacterial properties of marketed sulfacetamide containing drugs...
  5. Ungureanu M, Diculencu D, Stirbu C. Researches concerning the synthesis and antituberculosis action of some new sulphacetamide derivatives. Rev Med Chir Soc Med Nat Iasi. 2006;110:456-9 pubmed
    ..Early tests on Mycobacterium tuberculosis strains show susceptibility to these new compounds (for the tested concentrations). The new compounds represent a premise for obtaining new antimycobacterial agents. ..
  6. Spinks C, Wyatt G, Lee H, Morgan M. Molecular modeling of hapten structure and relevance to broad specificity immunoassay of sulfonamide antibiotics. Bioconjug Chem. 1999;10:583-8 pubmed
    ..structures of sulfonamide antibiotics led to the development of a hypothesis and the consequent synthesis of a sulfacetamide-protein immunogen aimed at the generation of broad specificity anti-sulfonamide antibodies...
  7. Sridhar M, Sharma S, Reddy M, Mruthyunjay P, Rao G. Clinicomicrobiological review of Nocardia keratitis. Cornea. 1998;17:17-22 pubmed
    ..caviae). All isolates were sensitive to gentamicin; however, topical 30% sulfacetamide was the preferred drug for treatment. Favorable outcome (healed scar) was achieved in 11...
  8. Dubina M, Fleischer A. Interaction of topical sulfacetamide and topical dapsone with benzoyl peroxide. Arch Dermatol. 2009;145:1027-9 pubmed publisher
    ..To investigate these interaction phenomena, topical dapsone gel and sulfacetamide sodium lotion were combined with various topical acne treatments, including benzoyl peroxides, clindamycin ..
  9. Sridhar M, Gopinathan U, Garg P, Sharma S, Rao G. Ocular nocardia infections with special emphasis on the cornea. Surv Ophthalmol. 2001;45:361-78 pubmed
    ..Available knowledge and clinical experience suggest that although sulfacetamide eyedrops can be tried as the initial drug, trimethoprim-sulfamethoxazole and amikacin are effective drugs...
  10. Russell J. Topical therapy for acne. Am Fam Physician. 2000;61:357-66 pubmed
    ..Patients with inflammatory lesions benefit from treatment with benzoyl peroxide, azelaic acid or topical antibiotics. Frequently, the use of comedonal and antibacterial agents is required. ..
  11. Errayess S, Lahcen A, Idrissi L, Marcoaldi C, Chiavarini S, Amine A. A sensitive method for the determination of Sulfonamides in seawater samples by Solid Phase Extraction and UV-Visible spectrophotometry. Spectrochim Acta A Mol Biomol Spectrosc. 2017;181:276-285 pubmed publisher
    ..method for determination of sulfonamide derivatives such as sulfanilamide (SAA), sulfadiazine (SDZ), sulfacetamide (SCT) sulfamethoxazole (SMX), sulfamerazine (SMR), sulfadimethoxine (SDX), sulfamethiazole (SMT) and ..
  12. Szymulska M, Zagorski Z. [The role of Chlamydia trachomatis in the etiology of conjunctivitis]. Klin Oczna. 1995;97:64-5 pubmed
    ..To turn attention to the etiological importance of chlamydia in chronic conjunctivitis...
  13. Byrom L, Zappala T, Muir J. Toxic epidermal necrolysis caused by over the counter eyedrops. Australas J Dermatol. 2013;54:144-6 pubmed publisher
    We present a case of a 15-year-old boy who developed toxic epidermal necrolysis (TEN) from sulfacetamide eyedrops...
  14. Solomenny A, Lyapunov Y, Kuzyaev R. Genetic variability of enterobacterial resistant integrons. Bull Exp Biol Med. 2011;151:619-21 pubmed
    ..A more active hybrid promotor type has been amplified in isolated Klebsiella oxytoca strains. Regulatory genetic modifications in MRI are fraught with the development of multiple drug resistance of opportunistic strains. ..
  15. Parsons M, Holland E, Agapitos P. Nocardia asteroides keratitis associated with extended-wear soft contact lenses. Can J Ophthalmol. 1989;24:120-2 pubmed
    ..The response to 30% sulfacetamide was dramatic. We review the clinical presentation of Nocardia keratitis and recommendations for management...
  16. Enzenauer R, Cornell F, Brooke J, Butler C. Nocardia asteroides keratitis: a case associated with soft contact lens wear. CLAO J. 1989;15:71-3 pubmed
    ..We describe the first case of Nocardia asteroides keratitis associated with an extended wear soft contact lens. We also describe its successful treatment with topical trimethoprim-sulfamethoxazole in combination sulfacetamide.
  17. Douglas R, Grove D, Elliott J, Looke D, Jordan A. Corneal ulceration due to Nocardia asteroides. Aust N Z J Ophthalmol. 1991;19:317-20 pubmed
    ..Microbiological examination of corneal scrapings permitted accurate diagnosis and suggested appropriate therapy. Nineteen other cases that have been described in the world literature are reviewed. ..
  18. Del Rosso J. A status report on the medical management of rosacea: focus on topical therapies. Cutis. 2002;70:271-5 pubmed
  19. Draelos Z. The multifunctionality of 10% sodium sulfacetamide, 5% sulfur emollient foam in the treatment of inflammatory facial dermatoses. J Drugs Dermatol. 2010;9:234-6 pubmed
    ..Food and Drug Administration (FDA) solely on the basis of safety. One of these is the combination 10% sodium sulfacetamide and 5% sulfur...
  20. Del Rosso J. Evaluating the role of topical therapies in the management of rosacea: focus on combination sodium sulfacetamide and sulfur formulations. Cutis. 2004;73:29-33 pubmed
    The combination of sodium sulfacetamide and sulfur is unique in the rosacea armamentarium because of its dual use as topical therapy and therapeutic cleanser...
  21. Vogh B, Godman D, Maren T. Measurement of aqueous humor flow following scleral injection of sulfacetamide as marker: effect of methazolamide, timolol, and pilocarpine. J Ocul Pharmacol. 1989;5:293-302 pubmed
    ..b>Sulfacetamide (SAC), a sulfonamide with low lipid solubility and pKa 5.4, is the marker of flow used here...
  22. Patel N, Shukla S, Zaki J, Feldman S. Oxymetazoline hydrochloride cream for facial erythema associated with rosacea. Expert Rev Clin Pharmacol. 2017;10:1049-1054 pubmed publisher
    ..covered: Current treatment options for the treatment of rosacea include metronidazole, azelaic acid, sodium sulfacetamide-sulfur, and brimonidine...
  23. Johansen S, Rask Pedersen E, Prause J. An ocular bioavailability comparison in rabbits of prednisolone acetate after repeated topical applications formulated as a high-viscosity gel and as an aqueous suspension. Acta Ophthalmol Scand. 1996;74:259-64 pubmed
    ..5% given in 1) Leogel using fusidic acid 1% with that obtained using 2) aqueous sulfacetamide sodium 10% as vehicle...
  24. Lebrun C. Rosac Cream With Sunscreens (sodium sulfacetamide 10% and sulfur 5%). Skinmed. 2004;3:92 pubmed
  25. Draelos Z. Facial hygiene and comprehensive management of rosacea. Cutis. 2004;73:183-7 pubmed
    ..This article reviews the use of therapeutic skin cleansers, including the newest category of prescription antimicrobial cleansers, which can enhance the overall management of this inflammatory dermatologic disorder. ..
  26. Sensoy D, Cevher E, Sarici A, Yilmaz M, Ozdamar A, Bergişadi N. Bioadhesive sulfacetamide sodium microspheres: evaluation of their effectiveness in the treatment of bacterial keratitis caused by Staphylococcus aureus and Pseudomonas aeruginosa in a rabbit model. Eur J Pharm Biopharm. 2009;72:487-95 pubmed publisher
    The aim of this study was to prepare bioadhesive sulfacetamide sodium (SA) microspheres to increase their residence time on the ocular surface and to enhance their treatment efficacy on ocular keratitis...
  27. Naik P, Chimatadar S, Nandibewoor S. Pharmacokinetic study on the mechanism of interaction of sulfacetamide sodium with bovine serum albumin: a spectroscopic method. Biopharm Drug Dispos. 2010;31:120-8 pubmed publisher
    The binding of sulfacetamide sodium (SAS) to bovine serum albumin (BSA) was investigated by spectroscopic methods, namely fluorescence, FT-IR and UV-vis absorption spectral studies...
  28. Keagy P, Oace S. Rat bioassay of wheat bran folate and effects of intestinal bacteria. J Nutr. 1989;119:1932-9 pubmed
    ..Further studies are needed on a variety of foods with and without phthalylsulfacetamide to evaluate the effect and importance of intestinal folate synthesis in the rat. ..
  29. Fischer P, Miles V, Stampfl D, Hoffman R, Wald E. Route of antibiotic administration for conjunctivitis. Pediatr Infect Dis J. 2002;21:989-90; author reply 990 pubmed
  30. Bar Ilan A. The Guinea Pig Blinking Test: a comparison with human responses. J Ocul Pharmacol Ther. 1997;13:207-12 pubmed
    ..the blinking response of the guinea pig to different concentrations of a topically applied ophthalmic drug, sulfacetamide. The number of human subjects noting pain upon instillation of various concentrations of sulfacetamide (3) was ..
  31. El Ragehy N, Hegazy M, Abdelhamid G, Tawfik S. Validated Chromatographic Methods for the Simultaneous Determination of Sulfacetamide Sodium and Prednisolone Acetate in their Ophthalmic Suspension. J Chromatogr Sci. 2017;55:1000-1005 pubmed publisher
    ..chromatographic methods have been developed, optimized and validated for the simultaneous determination of sulfacetamide sodium and prednisolone acetate in pure forms and in their binary mixture...
  32. Fallen R, Gooderham M. Rosacea: update on management and emerging therapies. Skin Therapy Lett. 2012;17:1-4 pubmed
    ..Furthermore, renewed research interest has led to the development of other emerging therapies including topical ivermectin, brimonidine and oxymetazoline that hold promise for patients suffering from this condition. ..
  33. Lindow K. Rosacea. An overview of diagnosis and management. Adv Nurse Pract. 2004;12:27-32 pubmed
  34. Briscoe D, Edelstein E, Zacharopoulos I, Keness Y, Kilman A, Zur F, et al. Actinomyces canaliculitis: diagnosis of a masquerading disease. Graefes Arch Clin Exp Ophthalmol. 2004;242:682-6 pubmed
    ..Fixation of smeared concretions on a slide in alcohol is simple and is diagnostic of the disease. We recommend long-term systemic penicillin treatment in Actinomyces canaliculitis. ..
  35. Akyol Salman I, Azizi S, Mumcu U, Ates O, Baykal O. Comparison of the efficacy of topical N-acetyl-cysteine and a topical steroid-antibiotic combination therapy in the treatment of meibomian gland dysfunction. J Ocul Pharmacol Ther. 2012;28:49-52 pubmed publisher
    ..the efficacy of topical N-acetyl-cysteine (NAC) with a topical steroid-antibiotic combination, betamethasone-sulfacetamide sodium therapy in patients with meibomian gland dysfunction (MGD)...
  36. Wolf K, Silapunt S. The use of sodium sulfacetamide in dermatology. Cutis. 2015;96:128-30 pubmed
    Sodium sulfacetamide is effective in the management of a variety of inflammatory facial dermatoses and often is used in combination with sulfur for a synergistic effect...
  37. Preisz K, Karpati S. [Rosacea: pathogenesis, clinical forms and therapy]. Orv Hetil. 2010;151:1209-14 pubmed publisher
    ..Authors in this article review current literature on new classification system of rosacea, as well as the main pathogenetic theories and current therapeutic options. ..
  38. Han R, Yu Z, Zhen T, Wang J. Survey of Veterinary Drug Residues in Raw Milk in Hebei Province, China. J Food Prot. 2017;:1890-1896 pubmed publisher
    ..Residues of four veterinary drugs, penicillin G, sulfacetamide, trimethoprim, and lincomycin, were detected in 12 (6.25%) raw milk samples, with detection ratios of 1.04, 0...
  39. Khosla P, Neeraj V, Gupta S, Satpathy G. Berberine, a potential drug for trachoma. Rev Int Trach Pathol Ocul Trop Subtrop Sante Publique. 1992;69:147-65 pubmed
    ..Efficacy of Berberine 0.2% when compared to sulfacetamide 20% was found to be superior in both the clinical course of trachoma and in achieving a fall in the serum ..
  40. Marchand C, Nadeau D. The distribution and kinetics of sulphacetamide in leukaemic mice. Br J Pharmacol. 1976;56:423-9 pubmed
    ..4 Some of these changes in the kinetics of sulphacetamide tissue distribution are compatible with delay in gastrointestinal absorption of the drug and its accumulation in the ascitic fluid. ..
  41. Trumbore M, Goldstein J, Gurge R. Treatment of papulopustular rosacea with sodium sulfacetamide 10%/sulfur 5% emollient foam. J Drugs Dermatol. 2009;8:299-304 pubmed
    ..Sodium sulfacetamide 10%/sulfur 5% emollient foam (SSSE foam) is formulated for topical administration and is fragrance free and ..
  42. Elston D. Demodex mites as a cause of human disease. Cutis. 2005;76:294-6 pubmed
  43. Zheng H, Wang P, Li J. [Determination of 12 sulfonamides in cosmetics by ultra performance liquid chromatography]. Se Pu. 2007;25:238-40 pubmed
    A method for the determination of 12 sulfonamides (SAs) (sulfanilamide, sulfamonomethoxine, sulfacetamide, sulfamethoxazole, sulfadiazine, sulfisoxazole, sulfathiazole, sulfadi-methoxine, sulfamerazine, sulfaquinoxaline, sulfamethazine, ..
  44. Del Rosso J. Adjunctive skin care in the management of rosacea: cleansers, moisturizers, and photoprotectants. Cutis. 2005;75:17-21; discussion 33-6 pubmed
    ..This review summarizes information regarding 3 classes of these products--cleansers, moisturizers, and photoprotectants--with emphasis on barrier function and skin irritation. ..
  45. Girdhar R, Jain V, Menon S, Agrawal Y. Spectrophotometric determination of sulphacetamide. Boll Chim Farm. 2002;141:311-4 pubmed
    ..07-1.1 mg of sulphacetamide. The various parameters for the optimum extraction conditions are discussed. The method is applied to the determination of sulphacetamide in dosage forms. ..
  46. Brown O, Wright C, Masaki M, Meyerhoff W. Ototoxicity of Vasocidin drops applied to the chinchilla middle ear. Arch Otolaryngol Head Neck Surg. 1988;114:56-9 pubmed
    ..Vasocidin Ophthalmic Solution (sulfacetamide sodium and prednisolone sodium phosphate) has been advocated as an alternative agent that may have fewer toxic ..
  47. Foulks G, Austin R, Knowlton G. Clinical comparison of topical solutions containing trimethoprim in treating ocular surface bacterial infections. J Ocul Pharmacol. 1988;4:111-5 pubmed
    ..clinical and microbiologic responses when compared to a solution containing, in addition to trimethoprim and polymyxin B, sulfacetamide. The sulfa component was not essential to produce desired clinical and microbiologic results.
  48. Herron M, O reilly M, Vanderhooft S. Refractory Demodex folliculitis in five children with acute lymphoblastic leukemia. Pediatr Dermatol. 2005;22:407-11 pubmed
    ..The one child who was treated with sodium sulfacetamide 10%, sulfur 5% formulation had resolution of the eruption...
  49. Hull C, Johnson S. A double-blind comparative study of sodium sulfacetamide lotion 10% versus selenium sulfide lotion 2.5% in the treatment of pityriasis (tinea) versicolor. Cutis. 2004;73:425-9 pubmed
    ..A double-blind comparative study between once-a-day sodium sulfacetamide lotion and selenium sulfide lotion was undertaken. Both treatments were safe and efficacious...
  50. Volford O, Takacs M, Vámos J. [Ion exchange interactions on silica gel in thin-layer chromatography. IV. Plate investigations by UV spectroscopy]. Acta Pharm Hung. 1996;66:133-40 pubmed
    ..These findings are interpreted by the ion exchange interactions between the pharmacon and silica gel. The results provide a deeper insight into the mechanisms of TLC process. ..
  51. Johansen S, Rask Pedersen E, Prause J. A bioavailability comparison in rabbits after a single topical ocular application of prednisolone acetate formulated as a high-viscosity gel and as an aqueous suspension. Acta Ophthalmol Scand. 1996;74:253-8 pubmed
    ..5% given in 1) Leogel using fusidic acid 1% with that obtained using 2) aqueous sulfacetamide sodium 10% as vehicle after 0.5, 1, 1.5, 2, 3, 6, 8 and 12 h (n = 6 at each time points) in 54 rabbits...
  52. Krawitz M, Perry H. Corneal involvement in Reye syndrome. Ann Ophthalmol. 1988;20:113-4 pubmed
    ..To our knowledge, this is the first reported case of stromal infiltration and pannus formation associated with this disorder. ..
  53. Seiverling E, Fernanadez E, Adams D. Epidermal growth factor receptor (EGFR) inhibitor associated skin eruption. J Drugs Dermatol. 2006;5:368-9 pubmed
    ..1% cream twice daily, clindamycin 1% lotion twice daily and sodium sulfacetamide lotion twice daily...