aniline compounds

Summary

Summary: Compounds that include the aminobenzene structure.

Top Publications

  1. Martino N, Lange Consiglio A, Cremonesi F, Valentini L, Caira M, Guaricci A, et al. Functional expression of the extracellular calcium sensing receptor (CaSR) in equine umbilical cord matrix size-sieved stem cells. PLoS ONE. 2011;6:e17714 pubmed publisher
    ..Their use as components of media for eUCM-MSC culture could be beneficial to obtain enough cells for down-stream purposes. ..
  2. Levinson N, Boxer S. Structural and spectroscopic analysis of the kinase inhibitor bosutinib and an isomer of bosutinib binding to the Abl tyrosine kinase domain. PLoS ONE. 2012;7:e29828 pubmed publisher
    ..Exploiting such differences could lead to inhibitors with improved selectivity. ..
  3. Cortes J, Kantarjian H, Brummendorf T, Kim D, Turkina A, Shen Z, et al. Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib. Blood. 2011;118:4567-76 pubmed publisher
    ..These data suggest bosutinib is effective and tolerable in patients with chronic phase imatinib-resistant or imatinib-intolerant CML. This trial was registered at http://www.clinicaltrials.gov as NCT00261846...
  4. Joshi A, Pontecorvo M, Clark C, Carpenter A, Jennings D, Sadowsky C, et al. Performance characteristics of amyloid PET with florbetapir F 18 in patients with alzheimer's disease and cognitively normal subjects. J Nucl Med. 2012;53:378-84 pubmed publisher
    ..In a separate set of subjects (AD, n = 10; YHCs, n = 10), test-retest reliability was evaluated by comparing intrasubject visual read ratings and SUVrs for 2 PET images acquired within 4 wk of each other...
  5. Shaik N, Zbidah M, Lang F. Inhibition of Ca(2+) entry and suicidal erythrocyte death by naringin. Cell Physiol Biochem. 2012;30:678-86 pubmed publisher
    ..In conclusion, naringin blunts the increase of cytosolic Ca(2+) concentration, the shrinkage, the cell membrane scrambling and thus the suicidal death of erythrocytes following energy depletion or oxidative stress...
  6. Kucherenko Y, Zelenak C, Eberhard M, Qadri S, Lang F. Effect of casein kinase 1? activator pyrvinium pamoate on erythrocyte ion channels. Cell Physiol Biochem. 2012;30:407-17 pubmed publisher
  7. Perera M, Lin S, Peterson Y, Bielawska A, Szulc Z, Bittman R, et al. Bax and Bcl-xL exert their regulation on different sites of the ceramide channel. Biochem J. 2012;445:81-91 pubmed publisher
    ..Molecular docking simulations of the lowest-energy binding poses of ceramides and Bcl-xL inhibitors to Bcl-xL were consistent with the results of our functional studies and propose potential binding modes...
  8. Qadri S, Bauer J, Zelenak C, Mahmud H, Kucherenko Y, Lee S, et al. Sphingosine but not sphingosine-1-phosphate stimulates suicidal erythrocyte death. Cell Physiol Biochem. 2011;28:339-46 pubmed publisher
    ..1 - 10 ?M) but not sphingosine-1- phosphate (0.1 - 10 ?M) increased [Ca(2+)](i), decreased cell volume and increased PS-exposure. The observations disclose sphingosine, but not sphingosine-1-phosphate, as a strong inducer of eryptosis...
  9. Zelenak C, Eberhard M, Jilani K, Qadri S, Macek B, Lang F. Protein kinase CK1? regulates erythrocyte survival. Cell Physiol Biochem. 2012;29:171-80 pubmed publisher
    ..In conclusion, CK1 isoform ? participates in the regulation of erythrocyte programmed cell death by modulating cytosolic Ca(2+) activity...

More Information

Publications61

  1. Villemagne V, Mulligan R, Pejoska S, Ong K, Jones G, O Keefe G, et al. Comparison of 11C-PiB and 18F-florbetaben for A? imaging in ageing and Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2012;39:983-9 pubmed publisher
    ..The purpose of this analysis was to compare data on cortical A? deposition in subjects who had undergone both (11)C-PiB (PiB) and (18)F-florbetaben (FBB) PET imaging...
  2. Ghashghaeinia M, Toulany M, Saki M, Bobbala D, Fehrenbacher B, Rupec R, et al. The NF?B pathway inhibitors Bay 11-7082 and parthenolide induce programmed cell death in anucleated Erythrocytes. Cell Physiol Biochem. 2011;27:45-54 pubmed publisher
    ..In conclusion, the pharmacological inhibitors of NF?B, Bay 11-7082 and parthenolide, interfere with the survival of erythrocytes involving mechanisms other than disruption of NF?B-dependent gene expression...
  3. Clark C, Pontecorvo M, Beach T, Bedell B, Coleman R, Doraiswamy P, et al. Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-? plaques: a prospective cohort study. Lancet Neurol. 2012;11:669-78 pubmed
    ..We therefore prospectively compared the sensitivity and specificity of amyloid PET imaging with neuropathology at autopsy...
  4. Davids M, Letai A. Targeting the B-cell lymphoma/leukemia 2 family in cancer. J Clin Oncol. 2012;30:3127-35 pubmed publisher
    ..Further exploitation of our understanding of the BCL-2 family promises to offer improved predictive biomarkers for oncologists and improved therapies for patients with cancer...
  5. Villain N, Chetelat G, Grassiot B, Bourgeat P, Jones G, Ellis K, et al. Regional dynamics of amyloid-? deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: a voxelwise PiB-PET longitudinal study. Brain. 2012;135:2126-39 pubmed publisher
    ..Furthermore, this study identified the existence of Pittsburgh compound 'accumulators' and 'non-accumulators', notably within the Pittsburgh compound B-negative group, which may be a relevant concept for future studies...
  6. Merino D, Khaw S, Glaser S, Anderson D, Belmont L, Wong C, et al. Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells. Blood. 2012;119:5807-16 pubmed publisher
    ..These results have profound implications for how BH3-mimetics induce apoptosis and how the use of these compounds can be optimized for treating lymphoid malignancies...
  7. Choi S, Schneider J, Bennett D, Beach T, Bedell B, Zehntner S, et al. Correlation of amyloid PET ligand florbetapir F 18 binding with A? aggregation and neuritic plaque deposition in postmortem brain tissue. Alzheimer Dis Assoc Disord. 2012;26:8-16 pubmed publisher
    ..This study used human autopsy brain tissue to evaluate the correlation between in vitro florbetapir F 18 binding and A? density measured by established neuropathologic methods...
  8. Gibbs Strauss S, Nasr K, Fish K, Khullar O, Ashitate Y, Siclovan T, et al. Nerve-highlighting fluorescent contrast agents for image-guided surgery. Mol Imaging. 2011;10:91-101 pubmed
    ..These results lay the foundation for the development of ideal nerve-highlighting fluorophores for image-guided surgery...
  9. Qadri S, Kucherenko Y, Zelenak C, Jilani K, Lang E, Lang F. Dicoumarol activates Ca2+-permeable cation channels triggering erythrocyte cell membrane scrambling. Cell Physiol Biochem. 2011;28:857-64 pubmed publisher
    ..In conclusion, dicoumarol stimulates suicidal death of erythrocytes by stimulating Ca(2+) entry and subsequent triggering of Ca(2+) dependent cell membrane scrambling...
  10. Bonomini M, Giardinelli A, Morabito C, Di Silvestre S, Di Cesare M, Di Pietro N, et al. Calcimimetic R-568 and its enantiomer S-568 increase nitric oxide release in human endothelial cells. PLoS ONE. 2012;7:e30682 pubmed publisher
    ..Although it has been postulated that calcimimetics may have a direct effect on CaSR in the blood vessels, further studies are needed to elucidate their vascular CaSR-dependent versus CaSR-independent effects...
  11. Souers A, Leverson J, Boghaert E, Ackler S, Catron N, Chen J, et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med. 2013;19:202-8 pubmed publisher
    ..These data indicate that selective pharmacological inhibition of BCL-2 shows promise for the treatment of BCL-2-dependent hematological cancers...
  12. Shaik N, Lupescu A, Lang F. Sunitinib-sensitive suicidal erythrocyte death. Cell Physiol Biochem. 2012;30:512-22 pubmed publisher
    ..Sunitinib, however, did not significantly modify cytosolic ATP and ceramide abundance. The present observations reveal that sunitinib is able to trigger suicidal death in erythrocytes even in the absence of nuclei and mitochondria...
  13. Cortes J, Kim D, Kantarjian H, Brummendorf T, Dyagil I, Griskevicius L, et al. Bosutinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: results from the BELA trial. J Clin Oncol. 2012;30:3486-92 pubmed
    ..Each drug had a distinct safety profile. ..
  14. Liao Y, Zhang C, Zhang Y, Strong V, Tang J, Li X, et al. Carbon nanotube/polyaniline composite nanofibers: facile synthesis and chemosensors. Nano Lett. 2011;11:954-9 pubmed publisher
    ..These nanofibrillar SWCNT/polyaniline composite nanostructures are promising materials for use as low-cost disposable sensors and as electrodes due to their widely tunable conductivities...
  15. Raczyńska E, Stępniewski T, Kolczyńska K. Consequence of one-electron oxidation and one-electron reduction for aniline. J Mol Model. 2011;17:3229-39 pubmed publisher
    ..The change of the tautomeric preferences for reduced aniline may partially explain the origin of the CH tautomers for reduced nucleobases (cytosine, adenine, and guanine)...
  16. Campone M, Bondarenko I, Brincat S, Hotko Y, Munster P, Chmielowska E, et al. Phase II study of single-agent bosutinib, a Src/Abl tyrosine kinase inhibitor, in patients with locally advanced or metastatic breast cancer pretreated with chemotherapy. Ann Oncol. 2012;23:610-7 pubmed publisher
    ..This phase II study evaluated single-agent bosutinib in pretreated patients with locally advanced or metastatic breast cancer...
  17. Newberg A, Arnold S, Wintering N, Rovner B, Alavi A. Initial clinical comparison of 18F-florbetapir and 18F-FDG PET in patients with Alzheimer disease and controls. J Nucl Med. 2012;53:902-7 pubmed publisher
    ..The purpose of this study was to determine how clinical interpretations of the (18)F-amyloid tracer florbetapir compares diagnostically with (18)F-FDG PET when evaluating patients with Alzheimer disease (AD) and controls...
  18. Musumeci F, Schenone S, Brullo C, Botta M. An update on dual Src/Abl inhibitors. Future Med Chem. 2012;4:799-822 pubmed publisher
    ..This review is an update on the most important dual inhibitors already in clinical trials and includes information regarding compounds that have appeared in the literature in recent years...
  19. Abed M, Towhid S, Shaik N, Lang F. Stimulation of suicidal death of erythrocytes by rifampicin. Toxicology. 2012;302:123-8 pubmed publisher
    ..In conclusion, exposure of human erythrocytes to rifampicin is followed by suicidal erythrocyte death or eryptosis, an effect at least partially due to increase of cytosolic Ca(2+) concentration and stimulation of ceramide formation...
  20. Liddle J, Atkinson F, Barker M, Carter P, Curtis N, Davis R, et al. Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorg Med Chem Lett. 2011;21:6188-94 pubmed publisher
    ..GSK143 is a potent and highly selective SYK inhibitor showing good efficacy in the rat Arthus model...
  21. Keller V Amsberg G, Brummendorf T. Novel aspects of therapy with the dual Src and Abl kinase inhibitor bosutinib in chronic myeloid leukemia. Expert Rev Anticancer Ther. 2012;12:1121-7 pubmed publisher
    ..This may be causative for its favorable hematologic toxicity profile. In this review, the authors give an overview on the mechanism of action and currently available preclinical and clinical data for bosutinib in CML...
  22. Landau S, Lu M, Joshi A, PONTECORVO M, Mintun M, Trojanowski J, et al. Comparing positron emission tomography imaging and cerebrospinal fluid measurements of ?-amyloid. Ann Neurol. 2013;74:826-36 pubmed publisher
    ..We examined agreement and disagreement between 2 biomarkers of ?-amyloid (A?) deposition (amyloid positron emission tomography [PET] and cerebrospinal fluid [CSF] A?1-42 ) in normal aging and dementia in a large multicenter study...
  23. Battistone M, Da Ros V, Salicioni A, Navarrete F, Krapf D, Visconti P, et al. Functional human sperm capacitation requires both bicarbonate-dependent PKA activation and down-regulation of Ser/Thr phosphatases by Src family kinases. Mol Hum Reprod. 2013;19:570-80 pubmed publisher
  24. Gatidis S, Zelenak C, Fajol A, Lang E, Jilani K, Michael D, et al. p38 MAPK activation and function following osmotic shock of erythrocytes. Cell Physiol Biochem. 2011;28:1279-86 pubmed publisher
    ..In conclusion, p38 kinase is expressed in erythrocytes and participates in the machinery triggering eryptosis following hyperosmotic shock...
  25. Villemagne V, Ong K, Mulligan R, Holl G, Pejoska S, Jones G, et al. Amyloid imaging with (18)F-florbetaben in Alzheimer disease and other dementias. J Nucl Med. 2011;52:1210-7 pubmed publisher
  26. Lipping L, Kütt A, Kaupmees K, Koppel I, Burk P, Leito I, et al. Acidity of anilines: calculations vs experiment. J Phys Chem A. 2011;115:10335-44 pubmed publisher
    ..The method proved to be rather accurate for showing pK(a) trends (R(2)=0.980 in DMSO). However, the predicted absolute pK(a) values were all somewhat lower (rmsd=2.49 kcal·mol(-1)) than the respective experimental values...
  27. Lang E, Jilani K, Zelenak C, Pasham V, Bobbala D, Qadri S, et al. Stimulation of suicidal erythrocyte death by benzethonium. Cell Physiol Biochem. 2011;28:347-54 pubmed publisher
    ..Benzethonium (5 ?M) significantly enhanced lactic acid formation but not ceramide abundance. The present observations disclose a novel effect of benzethonium, i.e. triggering of suicidal death of erythrocytes...
  28. Yamaguchi R, Janssen E, Perkins G, Ellisman M, Kitada S, Reed J. Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy. PLoS ONE. 2011;6:e24102 pubmed publisher
  29. Ewers M, Insel P, Jagust W, Shaw L, Trojanowski J, Aisen P, et al. CSF biomarker and PIB-PET-derived beta-amyloid signature predicts metabolic, gray matter, and cognitive changes in nondemented subjects. Cereb Cortex. 2012;22:1993-2004 pubmed
  30. Roberts A, Seymour J, Brown J, Wierda W, Kipps T, Khaw S, et al. Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease. J Clin Oncol. 2012;30:488-96 pubmed publisher
    ..A phase I trial in patients with CLL was conducted to evaluate the safety, pharmacokinetics, and biologic activity of oral navitoclax...
  31. Gupta V, Laws S, Villemagne V, Ames D, Bush A, Ellis K, et al. Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging. Neurology. 2011;76:1091-8 pubmed publisher
    ..The major objective of this cross-sectional study was to investigate total plasma apoE as well as levels of the apoE4 form in a large, highly characterized cohort which included both healthy controls and participants with early-stage AD...
  32. Fleisher A, Chen K, Liu X, Roontiva A, Thiyyagura P, Ayutyanont N, et al. Using positron emission tomography and florbetapir F18 to image cortical amyloid in patients with mild cognitive impairment or dementia due to Alzheimer disease. Arch Neurol. 2011;68:1404-11 pubmed publisher
  33. Zbidah M, Lupescu A, Shaik N, Lang F. Gossypol-induced suicidal erythrocyte death. Toxicology. 2012;302:101-5 pubmed publisher
    ..The present observations reveal a novel effect of gossypol on human erythrocytes, which contributes to or even accounts for the triggering of anemia by this substance...
  34. Khoury H, Cortes J, Kantarjian H, Gambacorti Passerini C, Baccarani M, Kim D, et al. Bosutinib is active in chronic phase chronic myeloid leukemia after imatinib and dasatinib and/or nilotinib therapy failure. Blood. 2012;119:3403-12 pubmed publisher
    ..Bosutinib may offer a new treatment option for patients with chronic-phase CML after treatment with multiple TKIs. This trial was registered at www.clinicaltrials.gov as NCT00261846...
  35. Corcoran R, Cheng K, Hata A, Faber A, Ebi H, Coffee E, et al. Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models. Cancer Cell. 2013;23:121-8 pubmed publisher
  36. Khurana L, Ali H, Olszewska T, Ahn K, Damaraju A, Kendall D, et al. Optimization of chemical functionalities of indole-2-carboxamides to improve allosteric parameters for the cannabinoid receptor 1 (CB1). J Med Chem. 2014;57:3040-52 pubmed publisher
    ..These positive allosteric modulators of orthosteric agonist binding nonetheless antagonized the agonist-induced G-protein coupling to the CB1 receptor, yet induced ?-arrestin mediated ERK1/2 phosphorylation. ..
  37. Sagolla K, Löhmannsröben H, Hille C. Time-resolved fluorescence microscopy for quantitative Ca2+ imaging in living cells. Anal Bioanal Chem. 2013;405:8525-37 pubmed publisher
    ..These results suggest that OGB-1 is suitable for 2P-FLIM measurements, which can gain access to cellular physiology. ..
  38. Rothschild G, Cohen L, Mizrahi A, Nelken I. Elevated correlations in neuronal ensembles of mouse auditory cortex following parturition. J Neurosci. 2013;33:12851-61 pubmed publisher
    ..Our results demonstrate changes in the correlation structure of neuronal activity as a result of a natural life event. ..
  39. Nakamura T, Miyoshi N, Ishii T, Nishikawa M, Ikushiro S, Watanabe T. Activation of transient receptor potential ankyrin 1 by quercetin and its analogs. Biosci Biotechnol Biochem. 2016;80:949-54 pubmed publisher
    ..On the other hand, TRPV1 (vanilloid receptor) did not respond to any of the flavonoids evaluated in this study. Therefore, these data suggest that the flavonoids would be promising ligands for the TRPA1. ..
  40. Khandelwal M, Kumar A. One-pot environmentally friendly amino acid mediated synthesis of N-doped graphene-silver nanocomposites with an enhanced multifunctional behavior. Dalton Trans. 2016;45:5180-95 pubmed publisher
    ..These nanocomposites exhibited a fairly high SERS activity for 4-aminothiophenol, employed as the probe molecule, and allowed its detection at a 50 nM concentration even for the fairly small sized Ag NPs used in the present work. ..
  41. Lyoo C, Cho H, Choi J, Hwang M, Hong S, Kim Y, et al. Tau Accumulation in Primary Motor Cortex of Variant Alzheimer's Disease with Spastic Paraparesis. J Alzheimers Dis. 2016;51:671-5 pubmed publisher
    ..We suspect that upper motor neuron dysfunctions may be attributed to excessive abnormal tau accumulation rather than amyloid-β in the primary motor cortex. ..
  42. Uesato S, Matsuura Y, Matsue S, Sumiyoshi T, Hirata Y, Takemoto S, et al. Discovery of new low-molecular-weight p53-Mdmx disruptors and their anti-cancer activities. Bioorg Med Chem. 2016;24:1919-26 pubmed publisher
    ..Furthermore, the results of oral administration experiments using xenografts in nude mice indicated that 1c reduced the volume of tumor masses to 49.0% and 36.6% that of the control at 100 mg/kg and 150 mg/kg, respectively, in 40 days. ..
  43. Högenauer M, Brendel M, Delker A, Därr S, Weiss M, Bartenstein P, et al. Impact of MRI-based Segmentation Artifacts on Amyloid- and FDG-PET Quantitation. Curr Alzheimer Res. 2016;13:597-607 pubmed
    ..06 cm³) accounted for much of the PET quantitation bias. Large segmentation artifacts need to be detected and resolved as they considerably bias PET quantitation, especially when PVEC is applied to PET data. ..
  44. Obayashi H, Kobayashi N, Nezu Y, Yamoto T, Shirai M, Asai F. Plasma 2-hydroxyglutarate and hexanoylcarnitine levels are potential biomarkers for skeletal muscle toxicity in male Fischer 344 rats. J Toxicol Sci. 2017;42:385-396 pubmed publisher
  45. Hong W, Iosub A, Stahl S. Pd-catalyzed Semmler-Wolff reactions for the conversion of substituted cyclohexenone oximes to primary anilines. J Am Chem Soc. 2013;135:13664-7 pubmed publisher
    ..The oxime N-O bond undergoes oxidative addition to Pd(0)(PCy3)2, and the product of this step has been characterized by X-ray crystallography and shown to undergo dehydrogenation to afford the aniline product. ..
  46. Srivastava S, Shalabney A, Khalaila I, Grüner C, Rauschenbach B, Abdulhalim I. SERS biosensor using metallic nano-sculptured thin films for the detection of endocrine disrupting compound biomarker vitellogenin. Small. 2014;10:3579-87 pubmed
    ..g., ELISA, as its response time is less than 3 minutes...
  47. Calcio Gaudino E, Rinaldi L, Rotolo L, Carnaroglio D, Pirola C, Cravotto G. Heterogeneous Phase Microwave-Assisted Reactions under COâ‚‚ or CO Pressure. Molecules. 2016;21:253 pubmed publisher
    ..Stubborn and time-consuming carbonylation-like heterogeneous reactions, which have not yet been studied under dielectric heating, may well find an outstanding ally in the present protocol. ..
  48. Kurup S, Joshi K. Exploring isoxazole and carboxamide derivatives as potential non-nucleoside reverse transcriptase inhibitors. J Mol Graph Model. 2016;65:113-28 pubmed publisher
    ..Thus a nitrile group, an amide and fluoro substitution turn out to be an important requisite for NNRT potential inhibitors. ..
  49. Schreiber S, Schreiber F, Lockhart S, Horng A, Bejanin A, Landau S, et al. Alzheimer Disease Signature Neurodegeneration and APOE Genotype in Mild Cognitive Impairment With Suspected Non-Alzheimer Disease Pathophysiology. JAMA Neurol. 2017;74:650-659 pubmed publisher
  50. Iwata T, Uchino T, Koyama A, Johmura Y, Koyama K, Saito T, et al. The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy. PLoS ONE. 2017;12:e0178221 pubmed publisher
    ..Our results thus reveal that combination treatment of CBP-93872 with known chemotherapeutic agents inhibits phosphorylation of ATR and Chk1, and induces cell death. ..
  51. Sevigny J, Suhy J, Chiao P, Chen T, Klein G, Purcell D, et al. Amyloid PET Screening for Enrichment of Early-Stage Alzheimer Disease Clinical Trials: Experience in a Phase 1b Clinical Trial. Alzheimer Dis Assoc Disord. 2016;30:1-7 pubmed publisher
    ..Amyloid PET imaging is an effective and feasible screening tool for enrollment of amyloid-positive patients with early stages of AD into clinical trials. ..
  52. Sitarek K, Gromadzińska J, Stetkiewicz J, Lutz P, Król M, Domeradzka Gajda K, et al. Developmental toxicity of N-methylaniline following prenatal oral administration in rats. Int J Occup Med Environ Health. 2016;29:479-92 pubmed publisher
    ..The objective of the study was to assess prenatal toxicity of N-methylaniline (NMA) administered by gavage to pregnant female rats...