Summary: A selective serotonin uptake inhibitor that is used in the treatment of depression.

Top Publications

  1. Mahmood D, Akhtar M, Vohora D, Khanam R. Comparison of antinociceptive and antidiabetic effects of sertraline and amitriptyline on streptozotocin-induced diabetic rats. Hum Exp Toxicol. 2010;29:881-6 pubmed publisher
    ..The aim of this study is to investigate the antinociceptive effects of sertraline (Ser) and amitriptyline (Ami) in diabetic rats, and additionally monitoring their effects on grip strength, ..
  2. Kasper S, Hajak G, Wulff K, Hoogendijk W, Montejo A, Smeraldi E, et al. Efficacy of the novel antidepressant agomelatine on the circadian rest-activity cycle and depressive and anxiety symptoms in patients with major depressive disorder: a randomized, double-blind comparison with sertraline. J Clin Psychiatry. 2010;71:109-20 pubmed publisher
    ..first antidepressant to be an agonist at MT(1)/MT(2) receptors and an antagonist at 5-HT(2C) receptors, versus sertraline with regard to the amplitude of the circadian rest-activity cycle and depressive and anxiety symptoms in ..
  3. Novack T, Banos J, Brunner R, Renfroe S, Meythaler J. Impact of early administration of sertraline on depressive symptoms in the first year after traumatic brain injury. J Neurotrauma. 2009;26:1921-8 pubmed publisher
    The potential for sertraline administered in the first 3 months after moderate to severe traumatic brain injury (TBI) to decrease the incidence of depression in the first year after injury was assessed in a double-blinded randomized ..
  4. Umene Nakano W, Yoshimura R, Ueda N, Suzuki A, Ikenouchi Sugita A, Hori H, et al. Predictive factors for responding to sertraline treatment: views from plasma catecholamine metabolites and serotonin transporter polymorphism. J Psychopharmacol. 2010;24:1764-71 pubmed publisher
    In the present study, we investigated the effects of sertraline on plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and serum brain-derived neurotrophic factor (BDNF) levels in 59 depressed patients ..
  5. Cooper Kazaz R, van der Deure W, Medici M, Visser T, Alkelai A, Glaser B, et al. Preliminary evidence that a functional polymorphism in type 1 deiodinase is associated with enhanced potentiation of the antidepressant effect of sertraline by triiodothyronine. J Affect Disord. 2009;116:113-6 pubmed publisher
    ..Triiodothyronine (T3) is used to potentiate the clinical effect of antidepressant drugs. Inter-individual differences in efficacy may be related to genetically-based variability in thyroid function...
  6. Romeo R, Knapp M, Hellier J, Dewey M, Ballard C, Baldwin R, et al. Cost-effectiveness analyses for mirtazapine and sertraline in dementia: randomised controlled trial. Br J Psychiatry. 2013;202:121-8 pubmed publisher
    ..To evaluate the cost-effectiveness of sertraline and mirtazapine compared with placebo for depression in dementia...
  7. Simmons J, Nathan P, Berger G, Allen N. Chronic modulation of serotonergic neurotransmission with sertraline attenuates the loudness dependence of the auditory evoked potential in healthy participants. Psychopharmacology (Berl). 2011;217:101-10 pubmed publisher
    ..we examined the chronic effect of serotonergic manipulation using the selective serotonin reuptake inhibitor, sertraline, on the LDAEP...
  8. O Connor C, Jiang W, Kuchibhatla M, Silva S, Cuffe M, Callwood D, et al. Safety and efficacy of sertraline for depression in patients with heart failure: results of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial. J Am Coll Cardiol. 2010;56:692-9 pubmed publisher
    The objective was to test the hypothesis that heart failure (HF) patients treated with sertraline will have lower depression scores and fewer cardiovascular events compared with placebo. Depression is common among HF patients...
  9. Schillani G, Capozzo M, Aguglia E, De Vanna M, Grassi L, Conte M, et al. 5-HTTLPR polymorphism of serotonin transporter and effects of sertraline in terminally ill cancer patients: report of eleven cases. Tumori. 2008;94:563-7 pubmed
    ..and mental adaptation to cancer in terminally ill and depressed cancer patients, in relation to treatment with sertraline and to the 5-HTTLPR genetic polymorphism...

More Information


  1. Sitges M, Aldana B, Gómez C, Nekrassov V. The antidepressant sertraline prevents the behavioral and EEG changes induced in two animal models of seizures. Epilepsy Behav. 2012;25:511-6 pubmed publisher
    In order to investigate a potential anticonvulsive action of sertraline (i.p...
  2. Kenna G, Zywiak W, McGeary J, Leggio L, McGeary C, Wang S, et al. A within-group design of nontreatment seeking 5-HTTLPR genotyped alcohol-dependent subjects receiving ondansetron and sertraline. Alcohol Clin Exp Res. 2009;33:315-23 pubmed publisher
    ..aim of this study was to match and mismatch L/L, S/S, or S/L genotypes with administration of ondansetron and sertraline. Fifteen nontreatment seeking alcohol-dependent individuals were randomized to 1 of 2 counterbalanced arms to ..
  3. Conners D, Rogers E, Armbrust K, Kwon J, Black M. Growth and development of tadpoles (Xenopus laevis) exposed to selective serotonin reuptake inhibitors, fluoxetine and sertraline, throughout metamorphosis. Environ Toxicol Chem. 2009;28:2671-6 pubmed publisher
    ..present study was to determine whether low environmentally relevant concentrations of the SSRIs fluoxetine and sertraline could impair growth and development in tadpoles of the African clawed frog (Xenopus laevis) and to evaluate if ..
  4. Demyttenaere K, Corruble E, Hale A, Quera Salva M, Picarel Blanchot F, Kasper S. A pooled analysis of six month comparative efficacy and tolerability in four randomized clinical trials: agomelatine versus escitalopram, fluoxetine, and sertraline. CNS Spectr. 2013;18:163-70 pubmed publisher
    A pooled-analysis on the long-term outcome in four head-to-head studies: agomelatine versus fluoxetine, sertraline, and (twice) escitalopram. Method A meta-analytic approach was used...
  5. Schuurmans J, Comijs H, Emmelkamp P, Gundy C, Weijnen I, van den Hout M, et al. A randomized, controlled trial of the effectiveness of cognitive-behavioral therapy and sertraline versus a waitlist control group for anxiety disorders in older adults. Am J Geriatr Psychiatry. 2006;14:255-63 pubmed
    ..the relative effectiveness of cognitive-behavioral therapy (CBT) compared with a selective serotonin reuptake inhibitor (SSRI; sertraline) in a randomized, controlled trial on the treatment of anxiety disorders in older adults.
  6. Mathers M, Klotz T, Roth S, Lümmen G, Sommer F. Safety and efficacy of vardenafil versus sertraline in the treatment of premature ejaculation: a randomised, prospective and crossover study. Andrologia. 2009;41:169-75 pubmed publisher
    We investigated safety and efficacy of vardenafil and sertraline in premature ejaculation (PE). Seventy-two men graded their primary PE on a scale of 0-8 (0 = almost never, 8 = almost always)...
  7. Zhou Z, Zhen J, Karpowich N, Law C, Reith M, Wang D. Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat Struct Mol Biol. 2009;16:652-7 pubmed publisher
    b>Sertraline and fluoxetine are selective serotonin re-uptake inhibitors (SSRIs) that are widely prescribed to treat depression. They exert their effects by inhibiting the presynaptic plasma membrane serotonin transporter (SERT)...
  8. Pettinati H, Oslin D, Kampman K, Dundon W, Xie H, Gallis T, et al. A double-blind, placebo-controlled trial combining sertraline and naltrexone for treating co-occurring depression and alcohol dependence. Am J Psychiatry. 2010;167:668-75 pubmed publisher
    ..authors provide results from a double-blind, placebo-controlled trial that evaluated the efficacy of combining approved medications for depression (sertraline) and alcohol dependence (naltrexone) in treating patients with both disorders.
  9. Kan R, Endou M, Unno Y. [A case of serotonin syndrome following minimum doses of sertraline]. Seishin Shinkeigaku Zasshi. 2009;111:1041-6 pubmed
    We report a 75-year-old woman developing serotonin syndrome following minimum doses of sertraline. She showed a depressed mood, insomnia, and general fatigue and was taking sulpiride at 300 mg/day, alprazolam at 1.2 mg/day, zopiclone at 7...
  10. Kitaichi Y, Inoue T, Nakagawa S, Boku S, Kakuta A, Izumi T, et al. Sertraline increases extracellular levels not only of serotonin, but also of dopamine in the nucleus accumbens and striatum of rats. Eur J Pharmacol. 2010;647:90-6 pubmed publisher
    ..We examined effects of sertraline, fluvoxamine, and paroxetine on extracellular serotonin, dopamine, and noradrenaline levels in the medial ..
  11. Rainey M, Korostyshevsky D, Lee S, Perlstein E. The antidepressant sertraline targets intracellular vesiculogenic membranes in yeast. Genetics. 2010;185:1221-33 pubmed publisher
    Numerous studies have shown that the clinical antidepressant sertraline (Zoloft) is biologically active in model systems, including fungi, which do not express its putative protein target, the serotonin/5-HT transporter, thus ..
  12. Mushtaq D, Ali A, Margoob M, Murtaza I, Andrade C. Association between serotonin transporter gene promoter-region polymorphism and 4- and 12-week treatment response to sertraline in posttraumatic stress disorder. J Affect Disord. 2012;136:955-62 pubmed publisher
    We examined the association between serotonin transporter (5HTTLPR) genotype (SS vs SL vs LL) and sertraline treatment outcome in posttraumatic stress disorder (PTSD).
  13. Rosenberg P, Drye L, Martin B, Frangakis C, Mintzer J, Weintraub D, et al. Sertraline for the treatment of depression in Alzheimer disease. Am J Geriatr Psychiatry. 2010;18:136-45 pubmed publisher
    ..The authors conducted a multicenter, randomized, placebo-controlled trial titled "Depression in Alzheimer's Disease-2" to assess the efficacy and tolerability of sertraline for depression in AD.
  14. Haskell S, Hermann G, Reinking B, Volk K, Peotta V, Zhu V, et al. Sertraline exposure leads to small left heart syndrome in adult mice. Pediatr Res. 2013;73:286-93 pubmed publisher
    b>Sertraline, a selective serotonin reuptake inhibitor (SSRI), is the most commonly prescribed therapy for maternal depression...
  15. Peng Z, Xue Y, Wang H, Wang H, Xue F, Kuang F, et al. Sertraline promotes hippocampus-derived neural stem cells differentiating into neurons but not glia and attenuates LPS-induced cellular damage. Prog Neuropsychopharmacol Biol Psychiatry. 2012;36:183-8 pubmed publisher
    b>Sertraline is one of the most commonly used antidepressants in clinic...
  16. Huang C, Kuo D, Chang K, Shieh P, Chen F, Fang Y, et al. Effect of the antidepressant sertraline on Ca2+ fluxes in Madin-Darby canine renal tubular cells. J Recept Signal Transduct Res. 2009;29:342-8 pubmed publisher
    The effect of the antidepressant sertraline on cytosolic-free Ca2+ concentrations ([Ca2+]i) in Madin Darby canine kidney (MDCK) cells is unclear...
  17. Kaddurah Daouk R, Bogdanov M, Wikoff W, Zhu H, Boyle S, Churchill E, et al. Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo. Transl Psychiatry. 2013;3:e223 pubmed publisher
    In this study, we characterized early biochemical changes associated with sertraline and placebo administration and changes associated with a reduction in depressive symptoms in patients with major depressive disorder (MDD)...
  18. Taler M, Miron O, Gil Ad I, Weizman A. Neuroprotective and procognitive effects of sertraline: in vitro and in vivo studies. Neurosci Lett. 2013;550:93-7 pubmed publisher
    ..Using human neuroblastoma cells (SHSY5Y), we found that sertraline and its derivative, desmethylsertraline, at low concentrations (1-10 ?M), induced potent neurotrophic activity...
  19. Forester B, Harper D, Jensen J, Ravichandran C, Jordan B, Renshaw P, et al. 31Phosphorus magnetic resonance spectroscopy study of tissue specific changes in high energy phosphates before and after sertraline treatment of geriatric depression. Int J Geriatr Psychiatry. 2009;24:788-97 pubmed publisher markers of energy metabolism, including high energy phosphate compounds (beta and total NTP, PCr) and pH, in older adults with depression compared with healthy controls, before and after a 12-week treatment trial of sertraline.
  20. Meyers B, Flint A, Rothschild A, Mulsant B, Whyte E, Peasley Miklus C, et al. A double-blind randomized controlled trial of olanzapine plus sertraline vs olanzapine plus placebo for psychotic depression: the study of pharmacotherapy of psychotic depression (STOP-PD). Arch Gen Psychiatry. 2009;66:838-47 pubmed publisher
    ..Evidence for the efficacy of combination pharmacotherapy has been limited and without positive trials in geriatric patients with major depression (MD) with psychotic features...
  21. Kranzler H, Armeli S, Tennen H, Covault J, Feinn R, Arias A, et al. A double-blind, randomized trial of sertraline for alcohol dependence: moderation by age of onset [corrected] and 5-hydroxytryptamine transporter-linked promoter region genotype. J Clin Psychopharmacol. 2011;31:22-30 pubmed publisher
    ..We conducted a 12-week, parallel-group, placebo-controlled trial of the efficacy of sertraline in alcohol dependence (AD)...
  22. Sarris J, Fava M, Schweitzer I, Mischoulon D. St John's wort (Hypericum perforatum) versus sertraline and placebo in major depressive disorder: continuation data from a 26-week RCT. Pharmacopsychiatry. 2012;45:275-8 pubmed publisher
    ..b>sertraline and placebo in major depressive disorder...
  23. Pousti A, Bakhtiarian A, Najafi R, Deemyad T, Brumand K, Hosseini M. Effect of sertraline on ouabain-induced arrhythmia in isolated guinea-pig atria. Depress Anxiety. 2009;26:E106-10 pubmed publisher
    The effect of sertraline a selective serotonin reuptake inhibitor antidepressant was studied on ouabain-induced toxicity (arrhythmia) in spontaneously beating isolated guinea-pig atria.
  24. Kocabay G, Yildiz M, Eksi Duran N, Ozkan M. Sinus arrest due to sertraline. Clin Cardiol. 2010;33:E114-5 pubmed publisher
    b>Sertraline is a selective serotonin reuptake inhibitor with established safety for the treatment of depression. Among the common adverse effects associated with sertraline are nausea, insomnia, diarrhea, somnolence, and dizziness...
  25. Roerig J, Steffen K, ZIMMERMAN C, Mitchell J, Crosby R, Cao L. Preliminary comparison of sertraline levels in postbariatric surgery patients versus matched nonsurgical cohort. Surg Obes Relat Dis. 2012;8:62-6 pubmed publisher
    ..The purpose of the present pilot trial was to determine to what extent RYGB alters the area under the plasma concentration/time curve (AUC(0-10.5)) of the antidepressant, sertraline at a community research center.
  26. Karaiskos D, Tzavellas E, Ilias I, Liappas I, Paparrigopoulos T. Agomelatine and sertraline for the treatment of depression in type 2 diabetes mellitus. Int J Clin Pract. 2013;67:257-60 pubmed publisher
    The present study compared the efficacy of agomelatine and sertraline in the treatment of symptoms of depression/anxiety, diabetes self-care and metabolic control in a sample of depressed patients with non-optimally controlled type 2 ..
  27. Dadić Hero E, Ružić K, Grahovac T, Graovac M, Palijan T, Sepić Grahovac D. Allergic reactions--outcome of sertraline and escitalopram treatments. Psychiatr Danub. 2011;23:120-2 pubmed
    ..In the end the patent agreed to take psychopharmaca. Therefore, sertraline was introduced in the treatment, but the patient experienced a severe allergic reaction (Qiuncke's oedema)...
  28. Uguz F, Sonmez E. Neuroleptic malignant syndrome following combination of sertraline and paroxetine: a case report. Gen Hosp Psychiatry. 2013;35:327.e7-327.e8 pubmed publisher
    ..This case report presents a female patient developing NMS following the use of a combination of sertraline and paroxetine.
  29. Keefe F, Shelby R, Somers T, Varia I, Blazing M, Waters S, et al. Effects of coping skills training and sertraline in patients with non-cardiac chest pain: a randomized controlled study. Pain. 2011;152:730-41 pubmed publisher
    ..This randomized clinical trial examined the separate and combined effects of CST and antidepressant medication (sertraline) in participants with non-cardiac chest pain...
  30. Chien J, Chou C, Pan C, Kuo C, Tsai J, Liao W, et al. The mechanism of sertraline-induced [Ca2+]i rise in human OC2 oral cancer cells. Hum Exp Toxicol. 2011;30:1635-43 pubmed publisher
    Effect of sertraline, an antidepressant, on cytosolic free Ca(2+) levels ([Ca(2+)](i)) in human cancer cells is unclear...
  31. Gaur V, Kumar A. Behavioral, biochemical and cellular correlates in the protective effect of sertraline against transient global ischemia induced behavioral despair: possible involvement of nitric oxide-cyclic guanosine monophosphate study pathway. Brain Res Bull. 2010;82:57-64 pubmed publisher
    ..Present study was conducted to elucidate the protective effect of sertraline and possible involvement of nitric oxide mechanism against transient global ischemia induced behavioral despair...
  32. Brunoni A, Valiengo L, Baccaro A, Zanão T, de Oliveira J, Goulart A, et al. The sertraline vs. electrical current therapy for treating depression clinical study: results from a factorial, randomized, controlled trial. JAMA Psychiatry. 2013;70:383-91 pubmed publisher
    ..Transcranial direct current stimulation (tDCS) trials for major depressive disorder (MDD) have shown positive but mixed results...
  33. Rollema H, Guanowsky V, Mineur Y, Shrikhande A, Coe J, Seymour P, et al. Varenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect. Eur J Pharmacol. 2009;605:114-6 pubmed publisher
    ..dose significantly enhanced the effects of moderately active doses of the selective serotonin reuptake inhibitor sertraline. These findings are consistent with the notion that reducing alpha4beta2 nicotinic acetylcholine receptor ..
  34. Vanderburg D, Batzar E, Fogel I, Kremer C. A pooled analysis of suicidality in double-blind, placebo-controlled studies of sertraline in adults. J Clin Psychiatry. 2009;70:674-83 pubmed identify possibly suicide-related adverse events in Pfizer-sponsored, phases 2 through 4, placebo-controlled, completed studies of sertraline in adult patients and evaluate the risk of suicidality with sertraline versus placebo.
  35. Brunoni A, Schestatsky P, Lotufo P, Bensenor I, Fregni F. Comparison of blinding effectiveness between sham tDCS and placebo sertraline in a 6-week major depression randomized clinical trial. Clin Neurophysiol. 2014;125:298-305 pubmed publisher
    ..To compare blinding integrity and associated factors for transcranial direct current stimulation (tDCS) vs. placebo-pill, the gold standard blinding method...
  36. Furukawa T, Akechi T, Shimodera S, Yamada M, Miki K, Watanabe N, et al. Strategic use of new generation antidepressants for depression: SUN(^_^)D study protocol. Trials. 2011;12:116 pubmed publisher
    ..Starting with these findings, this proposed trial aims to establish the optimum 1st line and 2nd line antidepressant treatment strategy among adult patients with a non-psychotic unipolar major depressive episode...
  37. Park J, Heah T, Gouffon J, Henry T, Sayler G. Global gene expression in larval zebrafish (Danio rerio) exposed to selective serotonin reuptake inhibitors (fluoxetine and sertraline) reveals unique expression profiles and potential biomarkers of exposure. Environ Pollut. 2012;167:163-70 pubmed publisher
    ..zebrafish (Danio rerio) were exposed (96 h) to selective serotonin reuptake inhibitors (SSRIs) fluoxetine and sertraline and changes in transcriptomes analyzed by Affymetrix GeneChip Zebrafish Array were evaluated to enhance ..
  38. Jariani M, Saaki M, Nazari H, Birjandi M. The effect of Olanzapine and Sertraline on personality disorder in patients with methadone maintenance therapy. Psychiatr Danub. 2010;22:544-7 pubmed
    ..If a drug could alleviate a wide range of symptoms, it would be more suitable. In these disorders drug addiction is very common. This fact makes the symptoms complicated and the treatment more difficult...
  39. Bot M, Carney R, Freedland K, Rubin E, Rich M, Steinmeyer B, et al. Inflammation and treatment response to sertraline in patients with coronary heart disease and comorbid major depression. J Psychosom Res. 2011;71:13-7 pubmed publisher
    ..We therefore studied the relationship between pretreatment markers of inflammation and treatment response in patients with CHD and major depression...
  40. Sheehan D, Kamijima K. An evidence-based review of the clinical use of sertraline in mood and anxiety disorders. Int Clin Psychopharmacol. 2009;24:43-60 pubmed
    b>Sertraline is a selective serotonin reuptake inhibitor that has been used and studied extensively throughout the world and found to be safe and well tolerated in numerous patient populations, including those with either psychiatric and/or ..
  41. Lanza di Scalea T, Hanusa B, Wisner K. Sexual function in postpartum women treated for depression: results from a randomized trial of nortriptyline versus sertraline. J Clin Psychiatry. 2009;70:423-8 pubmed
    ..The primary aim of this article is to describe sexual concerns in postpartum women with DSM-IV diagnoses of major depressive disorder (MDD) before and during treatment with antidepressants in an 8-week double-blind randomized trial...
  42. Royall D, Cordes J, Roman G, Velez A, Edwards A, Schillerstrom J, et al. Sertraline improves executive function in patients with vascular cognitive impairment. J Neuropsychiatry Clin Neurosci. 2009;21:445-54 pubmed publisher
    The authors reviewed 35 open-label sertraline trials for executive impairment in ischemic cerebrovascular disease...
  43. Banerjee S, Hellier J, Dewey M, Romeo R, Ballard C, Baldwin R, et al. Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial. Lancet. 2011;378:403-11 pubmed publisher
    ..We aimed to assess efficacy and safety of two of the most commonly prescribed drugs, sertraline and mirtazapine, compared with placebo.
  44. Ueda N, Yoshimura R, Umene Nakano W, Ikenouchi Sugita A, Hori H, Hayashi K, et al. Grapefruit juice alters plasma sertraline levels after single ingestion of sertraline in healthy volunteers. World J Biol Psychiatry. 2009;10:832-5 pubmed publisher
    ..We investigated the effects of grapefruit juice on the pharmacokinetics of sertraline in healthy volunteers.
  45. Phan K, Coccaro E, Angstadt M, Kreger K, Mayberg H, Liberzon I, et al. Corticolimbic brain reactivity to social signals of threat before and after sertraline treatment in generalized social phobia. Biol Psychiatry. 2013;73:329-36 pubmed publisher
    ..Although selective serotonin reuptake inhibitor (SSRI) treatment is known to be an effective treatment, little is known about the mechanism through which these agents exert their anxiolytic effects at a brain level in gSP...
  46. Brunoni A, Valiengo L, Baccaro A, Zanao T, de Oliveira J, Vieira G, et al. Sertraline vs. ELectrical Current Therapy for Treating Depression Clinical Trial--SELECT TDCS: design, rationale and objectives. Contemp Clin Trials. 2011;32:90-8 pubmed publisher
    ..Due to its profile, tDCS seems to be a safe and affordable approach...
  47. Renoir T, Pang T, Zajac M, Chan G, Du X, Leang L, et al. Treatment of depressive-like behaviour in Huntington's disease mice by chronic sertraline and exercise. Br J Pharmacol. 2012;165:1375-89 pubmed publisher
    ..Depression is the most common psychiatric disorder in Huntington's disease (HD) patients. Women are more prone to develop depression and such susceptibility might be related to 5-hydroxytryptaminergic (serotonergic) dysregulation...
  48. Aldana B, Sitges M. Sertraline inhibits pre-synaptic Na? channel-mediated responses in hippocampus-isolated nerve endings. J Neurochem. 2012;121:197-205 pubmed publisher
    In the present study, a possible sertraline action on cerebral pre-synaptic Na(+) channels was investigated...
  49. Li Y, Couch L, Higuchi M, Fang J, Guo L. Mitochondrial dysfunction induced by sertraline, an antidepressant agent. Toxicol Sci. 2012;127:582-91 pubmed publisher
    b>Sertraline, a selective serotonin reuptake inhibitor, has been used for the treatment of depression...
  50. Freeman E, Sammel M, Lin H, Rickels K, Sondheimer S. Clinical subtypes of premenstrual syndrome and responses to sertraline treatment. Obstet Gynecol. 2011;118:1293-300 pubmed publisher
    To estimate response of diagnosis and symptom-based subtypes to sertraline treatment.
  51. Atalay H, Solak Y, Biyik M, Biyik Z, Yeksan M, Uguz F, et al. Sertraline treatment is associated with an improvement in depression and health-related quality of life in chronic peritoneal dialysis patients. Int Urol Nephrol. 2010;42:527-36 pubmed publisher
    ..We aimed to determine prevalence of depression, its association with health-related quality of life (HRQoL) and effects of sertraline treatment in PD patients.
  52. Holland J, Bhogle M. Sertraline and mirtazapine as geriatric antidepressants. Psychiatr Danub. 2013;25 Suppl 2:S286-90 pubmed
    ..Unfortunately these can have significant side-effects in the elderly such as hyponatraemia. Sertraline is one such SSRI commonly used in the geriatric population...
  53. Wei F, Crain A, Whitebird R, Godlevsky O, O Connor P. Effects of paroxetine and sertraline on low-density lipoprotein cholesterol: an observational cohort study. CNS Drugs. 2009;23:857-65 pubmed publisher
    ..This study evaluated the effects of paroxetine and sertraline on low-density lipoprotein cholesterol (LDL-C)...
  54. Takahashi K, Miyoshi H, Otomo M, Osada K, Yamaguchi N, Nakashima H. Suppression of dynamin GTPase activity by sertraline leads to inhibition of dynamin-dependent endocytosis. Biochem Biophys Res Commun. 2010;391:382-7 pubmed publisher
    ..We previously showed that sertraline, a selective serotonin reuptake inhibitor (SSRI), is a mixed-type inhibitor of Dyn 1 with respect to both GTP ..
  55. Yildirim E, Erol K, Ulupinar E. Effects of sertraline on behavioral alterations caused by environmental enrichment and social isolation. Pharmacol Biochem Behav. 2012;101:278-87 pubmed publisher
    ..In this study, the effects of sertraline, a selective serotonin (5-HT) reuptake inhibitor, on anxiety- and depression-like behaviors were investigated in ..
  56. Bloch M, Meiboom H, Lorberblatt M, Bluvstein I, Aharonov I, Schreiber S. The effect of sertraline add-on to brief dynamic psychotherapy for the treatment of postpartum depression: a randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2012;73:235-41 pubmed publisher
    ..We hypothesized that psychotherapy and concurrent antidepressant treatment would be more effective than psychotherapy alone in the treatment of postpartum depression...
  57. Lin C, Robert F, Sukarieh R, Michnick S, Pelletier J. The antidepressant sertraline inhibits translation initiation by curtailing mammalian target of rapamycin signaling. Cancer Res. 2010;70:3199-208 pubmed publisher
    b>Sertraline, a selective serotonin reuptake inhibitor, is a widely used antidepressant agent. Here, we show that sertraline also exhibits antiproliferative activity...
  58. Carney R, Freedland K, Rubin E, Rich M, Steinmeyer B, Harris W. Omega-3 augmentation of sertraline in treatment of depression in patients with coronary heart disease: a randomized controlled trial. JAMA. 2009;302:1651-7 pubmed publisher
    ..Studies of depressed psychiatric patients have shown that antidepressant efficacy can be increased by augmentation with omega-3 fatty acids...
  59. Huang J, Chang H, Chou C, Shu S, Kuo C, Tsai J, et al. The mechanism of sertraline-induced [Ca(2+) ](i) rise in human PC3 prostate cancer cells. Basic Clin Pharmacol Toxicol. 2011;109:103-10 pubmed publisher
    The effect of sertraline, an antidepressant, on cytosolic-free Ca(2+) levels ([Ca(2+) ](i) ) in human cancer cells is unclear...
  60. Scalco A, Rondon M, Trombetta I, Laterza M, Azul J, Pullenayegum E, et al. Muscle sympathetic nervous activity in depressed patients before and after treatment with sertraline. J Hypertens. 2009;27:2429-36 pubmed publisher
    ..Sympathetic hyperactivity is one of the mechanisms involved in the increased cardiovascular risk associated with depression, and there is evidence that antidepressants decrease sympathetic activity...
  61. Stoddard F, Luthra R, Sorrentino E, Saxe G, Drake J, Chang Y, et al. A randomized controlled trial of sertraline to prevent posttraumatic stress disorder in burned children. J Child Adolesc Psychopharmacol. 2011;21:469-77 pubmed publisher
    This study evaluated the potential benefits of a centrally acting selective serotonin reuptake inhibitor, sertraline, versus placebo for prevention of symptoms of posttraumatic stress disorder (PTSD) and depression in burned children...
  62. Bhuiyan M, Petropoulos S, Gibb W, Matthews S. Sertraline alters multidrug resistance phosphoglycoprotein activity in the mouse placenta and fetal blood-brain barrier. Reprod Sci. 2012;19:407-15 pubmed publisher
    ..We hypothesized that the SSRI sertraline would decrease P-gp-mediated drug efflux at the placenta and fetal blood-brain barrier (BBB)-increasing P-gp ..
  63. Finn S, Uncles D, Willers J, Sable N. Early treatment of a quetiapine and sertraline overdose with Intralipid. Anaesthesia. 2009;64:191-4 pubmed publisher
    ..male patient following attempted suicide by oral ingestion of a potentially fatal overdose of quetiapine and sertraline. Intravenous Intralipid was given soon after initiation of basic resuscitation...