1 naphthylamine


Summary: A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.

Top Publications

  1. Mekapati S, Denny W, Kurup A, Hansch C. QSAR of anticancer compounds. Bis(11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides), bis(phenazine-1-carboxamides), and bis(naphthalimides). Bioorg Med Chem. 2001;9:2757-62 pubmed
    ..This is consistent with other QSAR of anticancer compounds where hydrophobic interactions are found to be unimportant...
  2. Niu C, Gui X, Zeng G, Yuan X. A ratiometric fluorescence sensor with broad dynamic range based on two pH-sensitive fluorophores. Analyst. 2005;130:1551-6 pubmed
    ..The successful fabrication of the proposed sensor provides an alternative concept to utilizing two or more fluorophores for the development of ratiometric sensors covering a broad range of pH...
  3. Alakomi H, Puupponen Pimiä R, Aura A, Helander I, Nohynek L, Oksman Caldentey K, et al. Weakening of salmonella with selected microbial metabolites of berry-derived phenolic compounds and organic acids. J Agric Food Chem. 2007;55:3905-12 pubmed
    ..In addition, organic acids present in berries, such as malic acid, sorbic acid, and benzoic acid, were shown to be efficient permeabilizers of Salmonella as shown by an increase in the NPN uptake assay and by LPS release...
  4. Wei W, Wang H, Jiang C. Spectrofluorimetric determination of dopamine using 1,5-bis(4,6-dicholro-1,3,5-triazinylamino) naphthalene. Luminescence. 2007;22:581-7 pubmed
    ..0 x 10(-7) mol/L-5.0 x 10(-5) mol/L and 4.0 x 10(-8) mol/L. This method is simple, practical, can afford good precision and accuracy and can be successfully applied to assess dopamine in injections and human serum samples...
  5. Noordman W, Janssen D. Rhamnolipid stimulates uptake of hydrophobic compounds by Pseudomonas aeruginosa. Appl Environ Microbiol. 2002;68:4502-8 pubmed
    ..These results indicate that an energy-dependent system is present in P. aeruginosa strain UG2 that mediates fast uptake of hydrophobic compounds in the presence of rhamnolipid...
  6. Noel G, Godon C, Fernet M, Giocanti N, Mégnin Chanet F, Favaudon V. Radiosensitization by the poly(ADP-ribose) polymerase inhibitor 4-amino-1,8-naphthalimide is specific of the S phase of the cell cycle and involves arrest of DNA synthesis. Mol Cancer Ther. 2006;5:564-74 pubmed
    ..The data suggest that increased response to radiotherapy by PARP inhibitors may be achieved only in rapidly growing tumors with a high S-phase content...
  7. Giardino L, Zanni M, Bettelli C, Savina M, Calza L. Regulation of glutamic acid decarboxylase mRNA expression in rat brain after sertraline treatment. Eur J Pharmacol. 1996;312:183-7 pubmed
    ..The involvement of presynaptic modulation of gamma-amino-butyric acid transmission in the anxiolytic effect of sertraline is discussed. ..
  8. Shibaev V, Veselovsky V, Lozanova A, Maltsev S, Danilov L, Forsee W, et al. Synthesis of dolichyl phosphate derivatives with fluorescent label at the omega-end of the chain, new tools to study protein glycosylation. Bioorg Med Chem Lett. 2000;10:189-92 pubmed
    ..These products serve as substrates for recombinant yeast Dol-P-mannose synthase. Fluorescence resonance energy transfer between a Trp residue of the enzyme and the 1-aminonaphtalene group of the Dol-P analogue was demonstrated...
  9. Parkesh R, Clive Lee T, Gunnlaugsson T. Highly selective 4-amino-1,8-naphthalimide based fluorescent photoinduced electron transfer (PET) chemosensors for Zn(II) under physiological pH conditions. Org Biomol Chem. 2007;5:310-7 pubmed
    ..For , the sensing of Zn(II) was achieved with Kd = 4 nM when measured in pH 7.4 buffered solution, in the presence of 1.1 mM of EGTA. ..

More Information

Publications106 found, 100 shown here

  1. Chusri S, Villanueva I, Voravuthikunchai S, Davies J. Enhancing antibiotic activity: a strategy to control Acinetobacter infections. J Antimicrob Chemother. 2009;64:1203-11 pubmed publisher
    ..baumannii to a variety of antibiotics was enhanced in the presence of ellagic and tannic acids. The use of such plant compounds might provide effective treatments for resistant Gram-negative bacterial infections. ..
  2. Chen G, Bao H, Yang P. Fabrication and performance of a three-dimensionally adjustable device for the amperometric detection of microchip capillary electrophoresis. Electrophoresis. 2005;26:4632-40 pubmed
    ..The new approach for the microchannel-electrode alignment should find a wide range of applications in CE, flowing injection analysis, and other microfluidic analysis systems. ..
  3. Zhang W, Chen J, Zhang Q, Pan B, Lu J. [Cooperative adsorption of 1-naphthol and 1-naphthylamine onto hyper-crosslinked polymeric adsorbents]. Huan Jing Ke Xue. 2006;27:727-31 pubmed
    ..The amino groups on NDA103 enhance the adsorption affinity as well as the cooperative coefficient of 1-naphthol. ..
  4. Turner R. Quality of life: experience with sertraline. Int Clin Psychopharmacol. 1994;9 Suppl 3:27-31 pubmed
    ..001) in all QOL domains measured. The QOL scales give a better indication of the effect of pervasive depressive symptoms on a patient's life than rating scales of depressive symptomatology.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  5. Belpaire F, Wijnant P, Temmerman A, Rasmussen B, Brøsen K. The oxidative metabolism of metoprolol in human liver microsomes: inhibition by the selective serotonin reuptake inhibitors. Eur J Clin Pharmacol. 1998;54:261-4 pubmed
    ..These findings need further investigation to determine their clinical relevance. ..
  6. Ji H, Hougaard C, Herrik K, Strøbaek D, Christophersen P, Shepard P. Tuning the excitability of midbrain dopamine neurons by modulating the Ca2+ sensitivity of SK channels. Eur J Neurosci. 2009;29:1883-95 pubmed publisher
  7. Veale E, Gunnlaugsson T. Synthesis, photophysical, and DNA binding studies of fluorescent Tröger's base derived 4-amino-1,8-naphthalimide supramolecular clefts. J Org Chem. 2010;75:5513-25 pubmed publisher
    ..The latter method gives outstanding binding constants for 1-3 in the range of 10(7) M(-1). ..
  8. Koe B, Koch S, Lebel L, Minor K, Page M. Sertraline, a selective inhibitor of serotonin uptake, induces subsensitivity of beta-adrenoceptor system of rat brain. Eur J Pharmacol. 1987;141:187-94 pubmed
    ..These findings suggest that increased serotonergic activity may be involved in the induction of subsensitivity of the beta-adrenoceptor system of rat brain by sertraline. ..
  9. Canavier C, Oprisan S, Callaway J, Ji H, Shepard P. Computational model predicts a role for ERG current in repolarizing plateau potentials in dopamine neurons: implications for modulation of neuronal activity. J Neurophysiol. 2007;98:3006-22 pubmed
    ..This study suggests that the ERG current may play a role in burst termination and the relief of depolarization block in vivo. ..
  10. Garcia S, Bodaño A, Pablos J, Gomez Reino J, Conde C. Poly(ADP-ribose) polymerase inhibition reduces tumor necrosis factor-induced inflammatory response in rheumatoid synovial fibroblasts. Ann Rheum Dis. 2008;67:631-7 pubmed
    ..PARP inhibition reduces the production of inflammatory mediators and the proliferation of RA FLS (in response to TNF), suggesting that PARP inhibitors could have therapeutic benefits in RA. ..
  11. Duan L, Wang Z, Hou Y, Wang Z, Gao G, Chen W, et al. The oxidation capacity of Mn3O4 nanoparticles is significantly enhanced by anchoring them onto reduced graphene oxide to facilitate regeneration of surface-associated Mn(III). Water Res. 2016;103:101-108 pubmed publisher
    ..Overall, these findings may guide the development of novel metal oxide-graphene nanocomposites for contaminant removal. ..
  12. Andricopulo A, Muller L, Filho V, Cani G, Roos J, Correa R, et al. Analgesic activity of cyclic imides: 1,8-naphthalimide and 1,4,5,8-naphthalenediimide derivatives. Farmaco. 2000;55:319-21 pubmed
    ..These results extend previous studies on the analgesic activity of cyclic imides. ..
  13. Cao Hoang L, Marechal P, Le Thanh M, Gervais P. Synergistic action of rapid chilling and nisin on the inactivation of Escherichia coli. Appl Microbiol Biotechnol. 2008;79:105-9 pubmed publisher
    ..Application involving the simultaneous treatment with nisin and rapid cold shock could thus be of value in controlling Gram negatives, enhancing microbiological safety and stability. ..
  14. Yavarone M, Shuey D, Tamir H, Sadler T, Lauder J. Serotonin and cardiac morphogenesis in the mouse embryo. Teratology. 1993;47:573-84 pubmed
    ..Dose-dependent effects of 5-HT on migration of outflow tract cells were also observed. Taken together, these results suggest that 5-HT may play a role in cardiac morphogenesis during endocardial cushion formation. ..
  15. Burke W, Dewan V, Wengel S, Roccaforte W, Nadolny G, Folks D. The use of selective serotonin reuptake inhibitors for depression and psychosis complicating dementia. Int J Geriatr Psychiatry. 1997;12:519-25 pubmed
  16. Eap C, Bouchoux G, Amey M, Cochard N, Savary L, Baumann P. Simultaneous determination of human plasma levels of citalopram, paroxetine, sertraline, and their metabolites by gas chromatography-mass spectrometry. J Chromatogr Sci. 1998;36:365-71 pubmed
    ..It is also useful for therapeutic drug monitoring of these three drugs and could possibly be adapted for the quantitation of the two other selective serotonin reuptake inhibitors on the market, namely fluoxetine and fluvoxamine. ..
  17. Veale E, Tocci G, Pfeffer F, Kruger P, Gunnlaugsson T. Demonstration of bidirectional photoinduced electron transfer (PET) sensing in 4-amino-1,8-naphthalimide based thiourea anion sensors. Org Biomol Chem. 2009;7:3447-54 pubmed publisher
  18. Montero R, Longarte A, Conde A, Redondo C, Castaño F, González Ramírez I, et al. Photophysics of 1-aminonaphthalene: a theoretical and time-resolved experimental study. J Phys Chem A. 2009;113:13509-18 pubmed publisher
    ..7 eV above the (1)L(a) minimum. The relaxation of a higher-lying singlet excited state, observed above 40 000 cm(-1) (4.96 eV) and calculated at 5.18 eV, has been also explored. ..
  19. Qin W, Silvestre M, Li Y, Franzreb M. High performance liquid chromatography of substituted aromatics with the metal-organic framework MIL-100(Fe): Mechanism analysis and model-based prediction. J Chromatogr A. 2016;1432:84-91 pubmed publisher
    ..55molL(-1), q*MOFmax,styrene or p-xylene=3.53molL(-1), and q*MOFmax,anilines=3.12molL(-1) corresponding to approximately 842 toluene and 838 styrene or p-xylene, and 740 aniline molecules per MIL-100(Fe) unit cell, respectively. ..
  20. Ocana Morgner C, Dankert J. Induction of complement sensitivity in Escherichia coli by citric acid and low pH. J Appl Microbiol. 2001;90:771-8 pubmed
    ..Complement resistance factors could also be potential targets in antimicrobial therapies. ..
  21. Strøbaek D, Hougaard C, Johansen T, Sørensen U, Nielsen E, Nielsen K, et al. Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hippocampal CA1 neurons. Mol Pharmacol. 2006;70:1771-82 pubmed
    ..NS8593 was further tested on mouse CA1 neurons in hippocampal slices and shown to inhibit the apaminand tubocurarine-sensitive SK-mediated afterhyperpolarizing current, at a concentration of 3 microM. ..
  22. Aalto Korte K, Suuronen K, Kuuliala O, Jolanki R. Contact allergy to 2,5-dimercapto-1,3,4-thiadiazole and phenyl-alpha-naphtylamine, allergens in industrial greases and lubricant oils--contact allergy to water-insoluble greases is uncommon but needs to be considered in some workers. Contact Dermatitis. 2008;58:93-6 pubmed publisher
    ..1 of our 2 cases had been sensitized from grease and the other from a guide-way oil. The latter case shows that machinists may become sensitized to lubricants that leak to the metalworking fluid system. ..
  23. Rajyaguru J, Muszynski M. Enhancement of Burkholderia cepacia antimicrobial susceptibility by cationic compounds. J Antimicrob Chemother. 1997;40:345-51 pubmed
    ..These data provide a rationale for investigating amino compounds as potential permeability-increasing agents against B. cepacia. ..
  24. Helander I, Alakomi H, Latva Kala K, Koski P. Polyethyleneimine is an effective permeabilizer of gram-negative bacteria. Microbiology. 1997;143 ( Pt 10):3193-9 pubmed
    ..In addition, a sensitizing effect to the nonionic detergent Triton X-100 was observed for P. aeruginosa. In conclusion, PEI was shown to be a potent permeabilizer of the outer membrane of Gram-negative bacteria. ..
  25. Armstrong S, Merrill A. Toward the elucidation of the catalytic mechanism of the mono-ADP-ribosyltransferase activity of Pseudomonas aeruginosa exotoxin A. Biochemistry. 2004;43:183-94 pubmed
    ..Detailed kinetic analysis revealed that the eEF-2 substrate shows sigmoidal kinetic behavior with the enzyme, and fluorescence resonance energy transfer measurements indicated that wheat germ eEF-2 is oligomeric in solution. ..
  26. Ghosh U, Bhattacharyya N. Benzamide and 4-amino 1,8 naphthalimide treatment inhibit telomerase activity by down-regulating the expression of telomerase associated protein and inhibiting the poly(ADP-ribosyl)ation of telomerase reverse transcriptase in cultured cells. FEBS J. 2005;272:4237-48 pubmed
  27. Zawertailo L, Busto U, Kaplan H, Sellers E. Comparative abuse liability of sertraline, alprazolam, and dextroamphetamine in humans. J Clin Psychopharmacol. 1995;15:117-24 pubmed
    ..Results from this study indicate that sertraline, at the doses tested, does not possess the behavioral effects profile considered to be indicative of abuse potential when compared with alprazolam and dextroamphetamine. ..
  28. Seeger M, von Ballmoos C, Eicher T, Brandstätter L, Verrey F, Diederichs K, et al. Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB. Nat Struct Mol Biol. 2008;15:199-205 pubmed publisher
    ..Regain of function for impaired mutants was obtained upon exposure to the reducing agent DTT. The results support the presence of the asymmetric AcrB trimer in E. coli membranes and the functional rotation mechanism. ..
  29. Martinez A, Bengoechea J, Cuttitta F. Molecular evolution of proadrenomedullin N-terminal 20 peptide (PAMP): evidence for gene co-option. Endocrinology. 2006;147:3457-61 pubmed
    ..The evolution of PAMP provides an example of an angiogenic peptide that developed antimicrobial capabilities without losing its original function. ..
  30. Yang Y, Bao J. An electrical pumping approach to eliminate sample bias in capillary electrokinetic injection. Electrophoresis. 2007;28:1063-71 pubmed
    ..Finally, a PI with grounded electrode was proposed and shown to be suitable for samples with low conductivity and ions with different mobility. ..
  31. Sørensen U, Strøbaek D, Christophersen P, Hougaard C, Jensen M, Nielsen E, et al. Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators ofsmall conductance Ca2+-activated K+ channels. J Med Chem. 2008;51:7625-34 pubmed publisher
    ..The first described compound in this class is NS8593 (14), and the most potent analogue identified in this study is the racemic compound 39 (NS11757), which reversibly inhibits SK3-mediated currents with a K(d) value of 9 nM. ..
  32. Veale E, Frimannsson D, Lawler M, Gunnlaugsson T. 4-Amino-1,8-naphthalimide-based Tröger's bases as high affinity DNA targeting fluorescent supramolecular scaffolds. Org Lett. 2009;11:4040-3 pubmed publisher
    ..These structures also undergo rapid cellular uptake, being localized within the nucleus within a few hours, and are cytotoxic against HL60 and (chronic myeloid leukemia) K562 cell lines. ..
  33. Seong M, Lee D. Silver Nanoparticles Against Salmonella enterica Serotype Typhimurium: Role of Inner Membrane Dysfunction. Curr Microbiol. 2017;74:661-670 pubmed publisher
    ..typhimurium. Contrary to the expected results, ROS do not influence growth inhibition of AgNPs. ..
  34. Cheng L, He Y, Tian Y, Liu B, Zhang Y, Zhou Q, et al. Comparative biotoxicity of N-Phenyl-1-naphthylamine and N-Phenyl-2-naphthylamine on cyanobacteria Microcystis aeruginosa. Chemosphere. 2017;176:183-191 pubmed publisher
    ..The toxicity is due to that only P1NA can be biotransformed to 1,4-naphthoquinone, which could induce overproduction of intracellular ROS as well as result in oxidative damage and growth inhibition of test organism. ..
  35. Nanri K, Niiyama K, Utsumi H, Sekine S, Katou H, Kougo K, et al. [A case of migrainous infarction accompanying idiopathic thrombocytopenic purpura]. Rinsho Shinkeigaku. 2002;42:868-72 pubmed
    ..In this patient, platelet destruction due to idiopathic thrombocytopinic purpura and subsequent release of serotonin seemed to have involved in the occurrence of migrainous infarction. ..
  36. Kabra D, Thiyagarajan M, Kaul C, Sharma S. Neuroprotective effect of 4-amino-1,8-napthalimide, a poly(ADP ribose) polymerase inhibitor in middle cerebral artery occlusion-induced focal cerebral ischemia in rat. Brain Res Bull. 2004;62:425-33 pubmed
    ..Our study suggests 4-ANI is a potent neuroprotective agent in focal cerebral ischemia and its neuroprotective effects may be attributed to reduction of NAD depletion and DNA fragmentation. ..
  37. Tcatchoff L, Nespoulous C, Pernollet J, Briand L. A single lysyl residue defines the binding specificity of a human odorant-binding protein for aldehydes. FEBS Lett. 2006;580:2102-8 pubmed
    ..Here, using site-directed mutagenesis and fluorescent probe displacements, we show that Lys112 is the major determinant for governing hOBP-2A specificity towards aldehydes and small carboxylic acids. ..
  38. Bai P, Sun S, Li Z, Qiao H, Su X, Yang F, et al. Ru/Cu Photoredox or Cu/Ag Catalyzed C4-H Sulfonylation of 1-Naphthylamides at Room Temperature. J Org Chem. 2017;: pubmed publisher
    ..In addition, control experiments suggested that this C4-H sulfonylation reaction might proceed via a single-electron-transfer process...
  39. Tsuchiya H. Stereospecificity in membrane effects of catechins. Chem Biol Interact. 2001;134:41-54 pubmed
  40. Ye L, Morgenstern J, Gee A, Hong G, Brown J, Lockhart A. Delineation of positron emission tomography imaging agent binding sites on beta-amyloid peptide fibrils. J Biol Chem. 2005;280:23599-604 pubmed
  41. Doi H, Tateishi T, Isobe N, Yamasaki R, Ohyagi Y, Kira J. [Sporadic hemiplegic migraine-like headache in a patient with systemic lupus erythematosus]. Rinsho Shinkeigaku. 2010;50:332-4 pubmed
    ..We propose that SLE should be considered as one of the differential diagnoses of SHM. ..
  42. Angus B, Fyfe J, Hancock R. Mapping and characterization of two mutations to antibiotic supersusceptibility in Pseudomonas aeruginosa. J Gen Microbiol. 1987;133:2905-14 pubmed
    ..The absB mutation caused a structurally undefined alteration in the physical interaction of EDTA and gentamicin with the outer membrane...
  43. Bagby R, Kennedy S, Schuller D, Dickens S, Minifie C, Levitt A, et al. Differential pharmacological treatment response in high angry hostile and low angry hostile depressed patients: a retrospective analysis. J Affect Disord. 1997;45:161-6 pubmed
    ..A 2 (high angry hostile/low angry hostile) x 3 (medication type) analysis of variance (ANOVA) was non-significant, indicating no differential treatment effects...
  44. Eisen J, Phillips K, Baer L, Beer D, Atala K, Rasmussen S. The Brown Assessment of Beliefs Scale: reliability and validity. Am J Psychiatry. 1998;155:102-8 pubmed
    ..The authors developed and evaluated the reliability and validity of the Brown Assessment of Beliefs Scale, a clinician-administered seven-item scale designed to assess delusions across a wide range of psychiatric disorders...
  45. Daniel W, Wojcikowski J. Interactions between promazine and antidepressants at the level of cellular distribution. Pharmacol Toxicol. 1997;81:259-64 pubmed
    ..In conclusion, the obtained results show that, regardless of the previously known metabolic interactions between psychotropics, interactions at the levels of cellular and body distribution are also feasible...
  46. Hu K, Morris M. Determination of alpha-naphthylisothiocyanate and metabolites alpha-naphthylamine and alpha-naphthylisocyanate in rat plasma and urine by high-performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2003;788:17-28 pubmed
    ..1-NITC and 1-NA were detected and quantified in rat plasma and urine, following the administration of a 25 mg/kg i.v. dose of 1-NITC to a female Sprague-Dawley rat...
  47. Lee A, Ross C, Zeng B, Singleton S. A molecular target for suppression of the evolution of antibiotic resistance: inhibition of the Escherichia coli RecA protein by N(6)-(1-naphthyl)-ADP. J Med Chem. 2005;48:5408-11 pubmed
    ..This and other inhibitors of RecA activities represent a new approach for understanding the molecular targets and pathways involved in the evolution of antibiotic resistance in bacteria...
  48. Azmi J, Griffin J, Shore R, Holmes E, Nicholson J. Chemometric analysis of biofluids following toxicant induced hepatotoxicity: a metabonomic approach to distinguish the effects of 1-naphthylisothiocyanate from its products. Xenobiotica. 2005;35:839-52 pubmed
    ..This indicates that metabonomics may be useful for following severity and mechanisms of toxicity in a series of related compounds during drug development...
  49. Wisner K, Perel J, Blumer J. Serum sertraline and N-desmethylsertraline levels in breast-feeding mother-infant pairs. Am J Psychiatry. 1998;155:690-2 pubmed
    ..The authors' goal was to study the serum sertraline levels of breast-feeding mothers and their infants...
  50. Chatterjee A, Chaudhuri S, Saha G, Gupta S, Chowdhury R. Effect of bile on the cell surface permeability barrier and efflux system of Vibrio cholerae. J Bacteriol. 2004;186:6809-14 pubmed
    ..cholerae in the presence of bile. Expression of acrAB, encoding an RND family efflux pump, was significantly increased in V. cholerae cells grown in vitro in the presence of bile and also in cells grown in rabbit intestine...
  51. Ellison M, Champlin F. Outer membrane permeability for nonpolar antimicrobial agents underlies extreme susceptibility of Pasteurella multocida to the hydrophobic biocide triclosan. Vet Microbiol. 2007;124:310-8 pubmed
    ..Moreover, susceptibility is independent of the presence of capsular material and the biocide is bactericidal in a concentration dependent manner...
  52. Saad A, El Sikaily A, Kholeif S, Khalil E, Mahrous H, Al Zabedi E, et al. Biological activity resulting from exposure to aquatic environmental genotoxic pollutants in northern Egypt. East Mediterr Health J. 2010;16:82-8 pubmed
    ..5, controls 5.3]. Frequencies for total chromosomal aberrations were significantly raised in the peripheral blood lymphocytes of fishermen in both areas [frequency (per 100 metaphases): Mediterranean 67, Lake Edku 45, controls 14]...
  53. O Donnell J, Grealy M. Neuroendocrine response to clonidine and 8-OH-DPAT in rats following chronic administration of desipramine or sertraline. Br J Pharmacol. 1992;105:863-8 pubmed
    ..Sertraline had no significant neurendocrine effects at a dose which significantly reduced gross activity...
  54. Sun X, Liu B. The fluorescence sensor for saccharide based on internal conversion. Luminescence. 2005;20:331-3 pubmed
    ..The binding force of BBNA with d-fructose was the strongest, and the stability constant (K) of D-fructose was 99.9 mol/L. Therefore, a selective recognition system based on IC was constructed for D-fructose...
  55. Niu H, Cai Y, Shi Y, Wei F, Mou S, Jiang G. Cetyltrimethylammonium bromide-coated titanate nanotubes for solid-phase extraction of phthalate esters from natural waters prior to high-performance liquid chromatography analysis. J Chromatogr A. 2007;1172:113-20 pubmed
    ..All the results indicated the application potential of titanate nanotubes as solid-phase extraction adsorbents to pre-treat water samples...
  56. Tang W, Stearns R, Wang R, Miller R, Chen Q, Ngui J, et al. Assessing and minimizing time-dependent inhibition of cytochrome P450 3A in drug discovery: a case study with melanocortin-4 receptor agonists. Xenobiotica. 2008;38:1437-51 pubmed publisher
    ..This case study highlights the importance of mechanistic studies in support of drug-discovery and decision-making processes...
  57. Zhang C, Huang W, Chen Z, Rustum A. Separation of chiral primary amino compounds by forming a sandwiched complex in reversed-phase high performance liquid chromatography. J Chromatogr A. 2010;1217:4965-70 pubmed publisher
  58. Lasne M, Pike V, Turton D. The radiosynthesis of [N-methyl-11C]-sertraline. Int J Rad Appl Instrum A. 1989;40:147-51 pubmed
    ..Preparations can be ready for i.v. injection 50 min from the end of radionuclide production...
  59. Byerley W, McConnell E, McCabe R, Dawson T, Grosser B, Wamsley J. Chronic administration of sertraline, a selective serotonin uptake inhibitor, decreased the density of beta-adrenergic receptors in rat frontoparietal cortex. Brain Res. 1987;421:377-81 pubmed
    ..Results of a saturation experiment indicated that the reduction in cortex layer IV was due to a change in number but not affinity of beta-adrenergic receptors...
  60. Koe B, Lebel L. Effects of serotoninergic agents on downregulation of beta-adrenoceptors by the selective serotonin reuptake inhibitor sertraline. Arch Int Pharmacodyn Ther. 1995;329:231-44 pubmed
    ..Whether the downregulation of brain beta-adrenoceptors by sertraline plays any role in its antidepressant activity cannot be deduced from these experiments...
  61. Kawai K, Osakada Y, Takada T, Fujitsuka M, Majima T. Lifetime regulation of the charge-separated state in DNA by modulating the oxidation potential of guanine in DNA through hydrogen bonding. J Am Chem Soc. 2004;126:12843-6 pubmed
    ..These results clearly demonstrate that hole transfer in DNA can be controlled through hydrogen bonding by introducing a substituent on the cytosine...
  62. Freeman M, Nolan P, Davis M, Anthony M, Fried K, Fankhauser M, et al. Pharmacokinetics of sertraline across pregnancy and postpartum. J Clin Psychopharmacol. 2008;28:646-53 pubmed publisher
    ..Despite nonsignificant mean pharmacokinetic changes, the range of pharmacokinetic changes across pregnancy warrants careful monitoring of depressive symptoms in women with MDD in late pregnancy and further study...
  63. Kovachich G, Aronson C, Brunswick D, Frazer A. Quantitative autoradiography of serotonin uptake sites in rat brain using [3H]cyanoimipramine. Brain Res. 1988;454:78-88 pubmed
    ..The properties of binding of [3H]cyanoimipramine make it an ideal ligand for the quantitative autoradiography of serotonin uptake sites...
  64. Caccia S, Anelli M, Codegoni A, Fracasso C, Garattini S. The effects of single and repeated anorectic doses of 5-hydroxytryptamine uptake inhibitors on indole levels in rat brain. Br J Pharmacol. 1993;110:355-9 pubmed
  65. Gao X, Zhang Y, Wang B. New boronic acid fluorescent reporter compounds. 2. A naphthalene-based on-off sensor functional at physiological pH. Org Lett. 2003;5:4615-8 pubmed
    ..This fluorescent sensor shows a 41-fold emission intensity increase upon addition of 50 mM fructose in 0.1 M aqueous phosphate buffer at pH 7.4...
  66. Cho D, Fujitsuka M, Choi K, Park M, Yoon U, Majima T. Intramolecular exciplex and intermolecular excimer formation of 1,8-naphthalimide-linker-phenothiazine dyads. J Phys Chem B. 2006;110:4576-82 pubmed
    ..The excited-state dynamics of the NI molecules in n-hexane were established by means of time-resolved fluorescence spectroscopy...
  67. Nohynek L, Alakomi H, Kähkönen M, Heinonen M, Helander I, Oksman Caldentey K, et al. Berry phenolics: antimicrobial properties and mechanisms of action against severe human pathogens. Nutr Cancer. 2006;54:18-32 pubmed
    ..Typhimurium. The amount of phenolic compounds decreased in all berries, but their antimicrobial activity was not influenced accordingly. Cloudberry, in particular, showed constantly strong antimicrobial activity during the storage...
  68. Watanabe M, Sofuni T, Nohmi T. Comparison of the sensitivity of Salmonella typhimurium strains YG1024 and YG1012 for detecting the mutagenicity of aromatic amines and nitroarenes. Mutat Res. 1993;301:7-12 pubmed
    ..These results suggested that YG1024 is more suitable than YG1012 for the efficient detection of mutagenic aromatic amines and nitroarenes...
  69. Gänzle M, Vogel R. On-line fluorescence determination of pressure mediated outer membrane damage in Escherichia coli. Syst Appl Microbiol. 2001;24:477-85 pubmed
    ..However, whereas reversible membrane damage occurred fast and in thermodynamic equilibrium with pressure conditions, irreversible outer membrane damage was a time dependent process...
  70. Alakomi H, Saarela M, Helander I. Effect of EDTA on Salmonella enterica serovar Typhimurium involves a component not assignable to lipopolysaccharide release. Microbiology. 2003;149:2015-21 pubmed
    ..The conclusion from these results is that in the early exponential phase the effect of EDTA in S. enterica involves a component that is independent of LPS release...
  71. Sato A, McNulty L, Cox K, Kim S, Scott A, Daniell K, et al. A novel class of in vivo active anticancer agents: achiral seco-amino- and seco-hydroxycyclopropylbenz[e]indolone (seco-CBI) analogues of the duocarmycins and CC-1065. J Med Chem. 2005;48:3903-18 pubmed
    ..Finally, compound 11a was not toxic to murine bone marrow cell growth in culture at a dose that was toxic for the previously reported compound 4...
  72. Shaaban K, Shaaban M, Grün Wollny I, Maier A, Fiebig H, Laatsch H. Julichrome Q6 glucuronide, a monomeric subunit of the julimycin B-I complex from a terrestrial Streptomyces sp. J Nat Prod. 2007;70:1545-50 pubmed
    ..B8335 and was also characterized. The high antibiotic activity of Streptomyces sp. GW6225 extracts was probably due to the thiazolyl cyclopeptide nosiheptide...
  73. Hastings C, Fiedler D, Bergman R, Raymond K. Aza Cope rearrangement of propargyl enammonium cations catalyzed by a self-assembled "nanozyme". J Am Chem Soc. 2008;130:10977-83 pubmed publisher
    ..The catalyzed reaction exhibits saturation kinetics: the rate data obeyed the Michaelis-Menten model of enzyme kinetics, and competitive inhibition using a nonreactive guest was demonstrated...
  74. Saletu B, Grünberger J. Drug profiling by computed electroencephalography and brain maps, with special consideration of sertraline and its psychometric effects. J Clin Psychiatry. 1988;49 Suppl:59-71 pubmed
    ..Adverse effects were minimal with both sertraline (100 mg) and zimelidine, while nausea and vomiting increased with sertraline 200 and 400 mg...
  75. Maj J, Rogoz Z, Skuza G. Some behavioral effects of 1,3-di-o-tolylguanidine, opipramol and sertraline, the sigma site ligands. Pol J Pharmacol. 1996;48:379-95 pubmed
    ..The above results indicate that the sigma site ligands studied differ in their pharmacological profile; however, it is still difficult to determine unequivocally whether they show agonistic or antagonistic properties...
  76. Balkowski G, Szemik Hojniak A, van Stokkum I, Zhang H, Buma W. Femtosecond excited state studies of the two-center three-electron bond driven twisted internal charge transfer dynamics in 1,8-bis(dimethylamino)naphthalene. J Phys Chem A. 2005;109:3535-41 pubmed
    ..The spectral and dynamic characteristics of the final species created in the experiments are shown to correspond well with what has been determined before for the relaxed emissive lpi state...
  77. Godon C, Cordelières F, Biard D, Giocanti N, Mégnin Chanet F, Hall J, et al. PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility. Nucleic Acids Res. 2008;36:4454-64 pubmed publisher
    ..PARP-1 inhibition and deletion thus have different outcomes in terms of SSBR and radiosensitivity...
  78. Sharma S, Kumar A, Arora M, Kaundal R. Neuroprotective potential of combination of resveratrol and 4-amino 1,8 naphthalimide in experimental diabetic neuropathy: focus on functional, sensorimotor and biochemical changes. Free Radic Res. 2009;43:400-8 pubmed publisher
    ..This study suggests the beneficial effect of combining resveratrol and 4-ANI in experimental diabetic neuropathy...
  79. Naito S, Tanaka K, Koga H, Kotoh S, Hirohata T, Kumazawa J. Cancer occurrence among dyestuff workers exposed to aromatic amines. A long term follow-up study. Cancer. 1995;76:1445-52 pubmed
    ..Although the occupational exposure to some aromatic amines is recognized to cause bladder carcinoma, the long term effect of such exposure on the risk for disease, including other malignant tumors, remains unknown...
  80. Daniel W, Wojcikowski J. Contribution of lysosomal trapping to the total tissue uptake of psychotropic drugs. Pharmacol Toxicol. 1997;80:62-8 pubmed
  81. Aurell C, Wistrom A. Critical aggregation concentrations of gram-negative bacterial lipopolysaccharides (LPS). Biochem Biophys Res Commun. 1998;253:119-23 pubmed
    ..typhimurium 14 micrograms LPS/ml and E.coli 0111:B4 22 micrograms LPS/ml, respectively. The results obtained suggests that critical aggregate concentration and solubility of LPS is a function of polysaccharide chain length...
  82. De Simoni M, De Luigi A, Clavenna A, Manfridi A. In vivo studies on the enhancement of serotonin reuptake by tianeptine. Brain Res. 1992;574:93-7 pubmed
    ..Both the biochemical and behavioral data indicate that in vivo tianeptine's effects on the serotoninergic system are likely to be due to serotonin uptake enhancement...
  83. Nakashima K, Inoue K, Mayahara K, Kuroda N, Hamachi Y, Akiyama S. Use of 3-(1,8-naphthalimido)propyl-modified silyl silica gel as a stationary phase for the high-performance liquid chromatographic separation of purine derivatives. J Chromatogr A. 1996;722:107-13 pubmed
    ..5 h and 3-6 h after ingestion, respectively...
  84. Gardner M, Baris B, Wilner K, Preskorn S. Effect of sertraline on the pharmacokinetics and protein binding of diazepam in healthy volunteers. Clin Pharmacokinet. 1997;32 Suppl 1:43-9 pubmed
    ..Therefore, it would be expected that sertraline would, similarly, have a minimal effect on the pharmacokinetic profile of other drugs metabolised by these hepatic isoenzymes...
  85. Perrin C, Ohta B. Symmetry of N-H-N hydrogen bonds in 1,8-bis(dimethylamino)naphthalene.H+ and 2,7-dimethoxy-1,8-bis(dimethylamino)naphthalene.H+. J Am Chem Soc. 2001;123:6520-6 pubmed
    ..The significance of this result for the role of low-barrier hydrogen bonds in enzyme-catalyzed reactions is discussed...
  86. Lee D, Powers J, Pflegerl K, Vasil M, Hancock R, Hodges R. Effects of single D-amino acid substitutions on disruption of beta-sheet structure and hydrophobicity in cyclic 14-residue antimicrobial peptide analogs related to gramicidin S. J Pept Res. 2004;63:69-84 pubmed
    ..These results further support the role of hydrophobicity of the nonpolar face as a major influence on microbial specificity, but also highlights the importance of a disrupted beta-sheet structure on antimicrobial activity...
  87. Zhang W, Chen J, Chen Q, He M, Pan B, Zhang Q. Effects of the surface chemistry of macroreticular adsorbents on the adsorption of 1-naphthol/1-naphthylamine mixtures from water. J Environ Sci (China). 2005;17:782-5 pubmed
    ..The simultaneous adsorption systems were confirmed to be helpful to the selective adsorption towards 1-naphthol according to the larger selective index...
  88. Kirk W. Photophysics of ANS. II: Charge transfer character of near-UV absorption and consequences for ANS spectroscopy. Biophys Chem. 2007;125:13-23 pubmed
    ..The other transition is from aniline itself. The expected energies of these now coupled bands in anilinonaphthalene and ANS are calculated, and the transition dipole moment for these transitions is derived...
  89. Prabhakaran P, Puranik V, Chandran J, Rajamohanan P, Hofmann H, Sanjayan G. Sterically controlled naphthalene homo-oligoamides with novel structural architectures. Org Biomol Chem. 2009;7:2458-65 pubmed publisher
  90. Seutin V, Liegeois J. SK channels are on the move. Br J Pharmacol. 2007;151:568-70 pubmed
    ..Together with other recent progress in the field, this finding enriches the repertoire of tools available to test the hypothesis that SK channels may be targets for future CNS drugs...
  91. Jing B, Chen X, Wang X, Yang C, Xie Y, Qiu H. Self-assembly vesicles made from a cyclodextrin supramolecular complex. Chemistry. 2007;13:9137-42 pubmed
  92. Zhao D, Zhao L, Zhu C, Shen X, Zhang X, Sha B. Comparative study of polymer containing beta-cyclodextrin and -COOH for adsorption toward aniline, 1-naphthylamine and methylene blue. J Hazard Mater. 2009;171:241-6 pubmed publisher
    ..P1 was obtained from nontoxic materials and through environment friendly procedures, so it was potentially an efficient and green adsorbent for water purification...