Summary: A sulfanilamide antimicrobial agent that is used to treat enteric infections.

Top Publications

  1. Kastalli S, El Aidli S, Daghfous R, Trabelsi S, Lakhal M, Loueslati M, et al. [Fixed drug eruption induced by sulfaguanidine]. Ann Dermatol Venereol. 2004;131:382-4 pubmed
    ..We describe nine cases of fixed drug eruption induced by sulfaguanidine, a sulfonamide with local action...
  2. Abidi S, Azim Y, Khan S, Khan A. Sulfaguanidine cocrystals: Synthesis, structural characterization and their antibacterial and hemolytic analysis. J Pharm Biomed Anal. 2018;149:351-357 pubmed publisher
    b>Sulfaguanidine (SG), belongs to the class of sulfonamide drug used as an effective antibiotic...
  3. De Vos J, Desmet G, Eeltink S. Enhancing detection sensitivity in gradient liquid chromatography via post-column refocusing and strong-solvent remobilization. J Chromatogr A. 2016;1455:86-92 pubmed publisher
    ..trap configuration and elution/remobilization conditions, a signal enhancement of a factor of 14 was achieved for sulfaguanidine (early-eluting compound in the gradient separation) and 7.3 for furazolidone (late-eluting compound).
  4. Yoshihashi Y, Yonemochi E, Makita M, Yamamura S, Fukuoka E, Terada K. Determination of hydration kinetics of sulfaguanidine anhydrate in aqueous solution by calorimetry. Chem Pharm Bull (Tokyo). 2000;48:208-10 pubmed
    ..b>Sulfaguanidine (SGN) anhydrate was used as a model compound for the measurement of hydration kinetics in water...
  5. Clare B, Scozzafava A, Supuran C. Protease inhibitors, part 13: Specific, weakly basic thrombin inhibitors incorporating sulfonyl dicyandiamide moieties in their structure. J Enzyme Inhib. 2001;16:1-13 pubmed
    ..Thus, the main finding of the present paper is that the sulfonyldicyandiamide group may constitute an interesting alternative for obtaining weakly basic, potent thrombin inhibitors, which bind with less affinity to trypsin. ..
  6. Sasaki H, Kojima M, Nakamura J, Shibasaki J. Enhancing effect of pyrrolidone derivatives on the transdermal penetration of sulfaguanidine, aminopyrine and Sudan III. J Pharmacobiodyn. 1990;13:200-5 pubmed
    The enhancing effect of pyrrolidone derivatives on the percutaneous penetration of sulfaguanidine, aminopyrine and sudan III was investigated using in vitro technique and excised rat skin...
  7. Białk Bielińska A, Kumirska J, Palavinskas R, Stepnowski P. Optimization of multiple reaction monitoring mode for the trace analysis of veterinary sulfonamides by LC-MS/MS. Talanta. 2009;80:947-53 pubmed publisher
    ..The method was validated for its analytical performance parameters and applied to the determination of those compounds in soil samples. ..
  8. De Liguoro M, Di Leva V, Gallina G, Faccio E, Pinto G, Pollio A. Evaluation of the aquatic toxicity of two veterinary sulfonamides using five test organisms. Chemosphere. 2010;81:788-93 pubmed publisher
    The aquatic toxicity of sulfaquinoxaline (SQO) and sulfaguanidine (SGD) was evaluated on the following test organisms: Daphnia magna (reproduction test), Pseudokirchneriella subcapitata, Scenedesmus dimorphus, Synecococcus leopoliensis (..
  9. Sanchez Pena M, Salinas F, Mahedero M, Aaron J. Spectrofluorimetric determination of sulphonamides in pharmaceutical compounds and foods. J Pharm Biomed Anal. 1992;10:805-8 pubmed
    ..The methods are suitable for determining 0.02-0.10 micrograms ml of SAC, 0.10-0.50 micrograms ml of SG, and 0.40-1.00 micrograms of SMT. ..

More Information


  1. Anees M, Steven F. Inhibition of a tumour protease with 3,4-dichloroisocoumarin, pentamidine-isethionate and guanidino derivatives. J Enzyme Inhib. 1994;8:213-21 pubmed
    ..The GB-I complexes can be dissociated with SDS treatment, resulting in the regain of GB activity. ..
  2. Gift A, Taylor L. Hyphenation of Raman spectroscopy with gravimetric analysis to interrogate water-solid interactions in pharmaceutical systems. J Pharm Biomed Anal. 2007;43:14-23 pubmed
    ..In each of the model systems, sulfaguanidine, cromolyn sodium, ranitidine HCl, amorphous sucrose and silica gel, spectroscopic changes were observed during ..
  3. Gift A, Luner P, Luedeman L, Taylor L. Manipulating hydrate formation during high shear wet granulation using polymeric excipients. J Pharm Sci. 2009;98:4670-83 pubmed publisher
    ..In this study, three model compounds, caffeine (CAF), carbamazepine (CBZ), and sulfaguanidine (SGN), were subjected to high shear wet granulation and phase transformations were monitored using in-line ..
  4. Wasfy A, Aly A. Simple synthesis of novel diphenylsulfapyrimidine acetates from chalcones and their antimicrobial activity. Folia Microbiol (Praha). 2003;48:51-5 pubmed
    Given the significant low yield (19-43%) in reported results on the cyclocondensation of sulfaguanidine acetate with chalcones, a careful reinvestigation was carried out...
  5. De Frutos C, de Barrio M, Tornero P, Barranco R, Rodriguez A, Rubio M. Erythema multiforme from sulfaguanidine. Contact Dermatitis. 2002;46:186-7 pubmed
  6. Cross R, Smairl A. Salt effects in capillary zone electrophoresis. V. Adsorption and retention of electrically neutral analytes. J Chromatogr A. 2001;929:113-21 pubmed
    ..A mechanism for adsorption is proposed and the generality of the phenomenon is discussed. ..
  7. Ulus R, Kaya M, Demir D, Tunca E, Bülbül M. Three-component synthesis and carbonic anhydrase inhibitory properties of novel octahydroacridines incorporating sulfaguanidine scaffold. J Enzyme Inhib Med Chem. 2016;31:63-69 pubmed
    Novel sulfaguanidines incorporating acridine moiety were synthesized by the reaction of cyclohexane-1,3-dione, sulfaguanidine, and aromatic aldehydes...
  8. Sheikha G, Al Sha er M, Taha M. Some sulfonamide drugs inhibit ATPase activity of heat shock protein 90: investigation by docking simulation and experimental validation. J Enzyme Inhib Med Chem. 2011;26:603-9 pubmed publisher
    ..0, 2.6, and 1.5 ?M, respectively. Our results suggest that these well-established sulfonamides can be good leads for subsequent optimization into potent Hsp90 inhibitors. ..
  9. Sao Emani C, Williams M, Wiid I, Baker B, Carolis C. Compounds with Potential Activity against Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..that ΔegtA and ΔmshA mutants had increased susceptibility to azaguanine (Aza) and sulfaguanidine (Su); ΔegtB and ΔegtE mutants had increased susceptibility to bacitracin (Ba); and Î..
  10. Balakrishnan V, Terry K, Toito J. Determination of sulfonamide antibiotics in wastewater: a comparison of solid phase microextraction and solid phase extraction methods. J Chromatogr A. 2006;1131:1-10 pubmed
    ..In this study, we focused on developing methods to accurately determine 10 sulfonamide antibiotics: sulfaguanidine, sulfacetamide, sulfadiazine, sulfathiazine, sulfapyridine, sulfamerazine, sulfamethazine, sulfamethoxazole, ..
  11. Diez N, de la Peña A, García M, Gil D, Cañada Cañada F. Fluorimetric determination of sulphaguanidine and sulphamethoxazole by host-guest complexation in beta-cyclodextrin and partial least squares calibration. J Fluoresc. 2007;17:309-18 pubmed
    ..The proposed procedure was validated by comparing the obtained results with a HPLC method, with satisfactory results for the assayed method. ..
  12. Wong T, Chan L, Lee H, Heng P. Release characteristics of pectin microspheres prepared by an emulsification technique. J Microencapsul. 2002;19:511-22 pubmed
    ..The extent of drug-pectin interaction was highest in microspheres containing sulphanilamide, followed by sulphaguanidine and sulphathiazole, opposite to that of drug content. ..
  13. Białk Bielińska A, Maszkowska J, Mrozik W, Bielawska A, Kołodziejska M, Palavinskas R, et al. Sulfadimethoxine and sulfaguanidine: their sorption potential on natural soils. Chemosphere. 2012;86:1059-65 pubmed publisher
    ..Therefore, in this work we have determined the sorption potential of sulfadimethoxine and sulfaguanidine on various natural soils...
  14. Čizmić M, Babić S, Kastelan Macan M. Multi-class determination of pharmaceuticals in wastewaters by solid-phase extraction and liquid chromatography tandem mass spectrometry with matrix effect study. Environ Sci Pollut Res Int. 2017;24:20521-20539 pubmed publisher
    ..Method detection limits were in the range of 2.0-204.0 ng L-1 for WWTP influent except for sulfaguanidine and dexamethasone. Also, method detection limits for WWTP effluent were from 1.0 to 115.4 ng L-1...
  15. Maszkowska J, Kołodziejska M, Białk Bielińska A, Mrozik W, Kumirska J, Stepnowski P, et al. Column and batch tests of sulfonamide leaching from different types of soil. J Hazard Mater. 2013;260:468-74 pubmed publisher
    ..size distribution, organic matter content and pH, each spiked with sulfonamides (sulfadimethoxine (SDM), sulfaguanidine (SGD), sulfisoxazole (SX))...
  16. Wan L, Chui W. Deviation of the ratio of drugs in a two-component mixture encapsulated in cellulose phthalate microspheres. J Microencapsul. 1995;12:417-23 pubmed
    ..When more than one drug is required to be microencapsulated, the drug ratio may change if the drugs have different solubility in acetic acid. ..
  17. Angius F, Piras E, Uda S, Madeddu C, Serpe R, Bigi R, et al. Antimicrobial sulfonamides clear latent Kaposi sarcoma herpesvirus infection and impair MDM2-p53 complex formation. J Antibiot (Tokyo). 2017;70:962-966 pubmed publisher
    ..These findings detected a new molecular target for the activity of sulfonamides and offer a new potential perspective for treating KSHV-induced lymphoproliferative diseases. ..
  18. Petz M. [Fluorometric determination of sulfanilamide and sulfaguanidine residues in animal tissues with high-performance-liquid chromatography]. J Chromatogr. 1987;423:217-25 pubmed
    ..V. = 6%) for SG. Concentrations of 0.27 mg/kg for SA and 0.05 mg/kg for SG were analyzed in muscle meat of a swine which received a single intramuscular injection of 2.1 g SA and 0.6 g SG and was slaughtered 24 h later. ..
  19. Nakanishi K, Masada M, Nadai T. Improvement by adjuvants on the rectal bioavailability of non-absorbable drugs following administration of suppository. J Pharmacobiodyn. 1990;13:760-5 pubmed
    ..on the release rate of drugs and the absorption of non-absorbable drugs such as sulfanilic acid (SA) and sulfaguanidine (SG), was investigated following the rectal administration of suppositories...
  20. Sharaby C. Preparation, characterization and biological activity of Fe(III), Fe(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and UO(2)(II) complexes of new cyclodiphosph(V)azane of sulfaguanidine. Spectrochim Acta A Mol Biomol Spectrosc. 2005;62:326-34 pubmed
    Novel hexachlorocyclodiphosph(V)azane of sulfaguanidine, H(4)L, l,3-[N'-amidino-sulfanilamide]-2,2,2,4,4,4-hexachlorocyclodiphosph(V)azane was prepared and its coordination behaviour towards the transition metal ions Fe(III), Fe(II), Co(..
  21. Arias J, Fernandez Rivas M, Martinez M, Senent C. Fixed drug eruption caused by sulfaguanidine. Dermatology. 1994;189:196-7 pubmed
    We report a patient who developed a fixed drug eruption (FDE) due to sulfaguanidine. This drug has not been previously implicated as a cause of FDE. The diagnosis was confirmed by an oral provocation and a biopsy of the lesion...
  22. Cui Y, Zhang H, Ma Y, Dai C, Cui J. [Synthesis and identification of artificial antigens for sulfaguanidine and sulfathiazole]. Wei Sheng Yan Jiu. 2010;39:440-3 pubmed
    To prepare artificial antigens of sulfaguanidine and sulfathiazole for detecting sulfaguanidine and sulfathiazole in foods of animal origin...
  23. Cui C, Jin L, Jiang L, Han Q, Lin K, Lu S, et al. Removal of trace level amounts of twelve sulfonamides from drinking water by UV-activated peroxymonosulfate. Sci Total Environ. 2016;572:244-251 pubmed publisher
    ..b>Sulfaguanidine, sulfadiazine, sulfamerazine, sulfamethazine, sulfathiazole, sulfamethoxydiazine, and sulfadimethoxine were be ..