diazoxide

Summary

Summary: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.

Top Publications

  1. Maedler K, Størling J, Sturis J, Zuellig R, Spinas G, Arkhammar P, et al. Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective pot. Diabetes. 2004;53:1706-13 pubmed
    ..Treatment of type 1 and type 2 diabetic patients with the potassium channel opener diazoxide partially restores insulin secretion...
  2. Ma G, Chen S. Diazoxide and N omega-nitro-L-arginine counteracted A beta 1-42-induced cytotoxicity. Neuroreport. 2004;15:1813-7 pubmed
    ..Our study showed that diazoxide, a K(+) channel opener, could counteract the effects of A beta(1-42) and protect cells from A beta(1-42)-induced ..
  3. Adebiyi A, McNally E, Jaggar J. Sulfonylurea receptor-dependent and -independent pathways mediate vasodilation induced by ATP-sensitive K+ channel openers. Mol Pharmacol. 2008;74:736-43 pubmed publisher
    ..Here, we investigated the molecular mechanisms by which diazoxide and pinacidil induce vasodilation by studying diameter regulation of wild-type [SUR2(+/+)] and sulfonylurea ..
  4. Virgili N, Espinosa Parrilla J, Mancera P, Pastén Zamorano A, Gimeno Bayon J, Rodriguez M, et al. Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis. J Neuroinflammation. 2011;8:149 pubmed publisher
    ..In this study, we have examined the effect of oral administration of KATP channel opener diazoxide on induced experimental autoimmune encephalomyelitis (EAE), a mouse model of MS...
  5. Hoe F, Thornton P, Wanner L, Steinkrauss L, Simmons R, Stanley C. Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism. J Pediatr. 2006;148:207-12 pubmed
    ..b>Diazoxide was effective in 19 of the 21 neonates treated...
  6. Liu D, Pitta M, Lee J, Ray B, Lahiri D, Furukawa K, et al. The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease. J Alzheimers Dis. 2010;22:443-57 pubmed publisher
    ..of drugs that activate KATP channels in AD, we first characterized the effects of the KATP channel opener diazoxide on cultured neurons, and then determined its ability to modify the disease process in the 3xTgAD mouse model of ..
  7. Kimura S, Zhang G, Nishiyama A, Shokoji T, Yao L, Fan Y, et al. Mitochondria-derived reactive oxygen species and vascular MAP kinases: comparison of angiotensin II and diazoxide. Hypertension. 2005;45:438-44 pubmed
    ..potassium [mitoK(ATP)] channels) and tempol (a superoxide dismutase mimetic), the effects of Ang II and diazoxide (a mitoK(ATP) channel opener) were compared on redox-sensitive mitogen-activated protein (MAP) kinase activation ..
  8. Sayed S, Langdon D, Odili S, Chen P, Buettger C, Schiffman A, et al. Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism caused by glucokinase activating mutations. Diabetes. 2009;58:1419-27 pubmed publisher
    ..Child 1 had an ins454A mutation, child 2 a W99L mutation, and child 3 an M197I mutation. Diazoxide treatment was effective in child 3 but ineffective in child 1 and only partially effective in child 2...
  9. Brustovetsky T, Shalbuyeva N, Brustovetsky N. Lack of manifestations of diazoxide/5-hydroxydecanoate-sensitive KATP channel in rat brain nonsynaptosomal mitochondria. J Physiol. 2005;568:47-59 pubmed
    Pharmacological modulation of the mitochondrial ATP-sensitive K+ channel (mitoKATP) sensitive to diazoxide and 5-hydroxydecanoate (5-HD) represents an attractive strategy to protect cells against ischaemia/reperfusion- and stroke-related ..

More Information

Publications62

  1. Hansson M, Morota S, Teilum M, Mattiasson G, Uchino H, Elmér E. Increased potassium conductance of brain mitochondria induces resistance to permeability transition by enhancing matrix volume. J Biol Chem. 2010;285:741-50 pubmed publisher
    ..The putative mitoK(ATP) channel opener diazoxide did not mimic the effect of valinomycin...
  2. Raval A, Dave K, DeFazio R, Perez Pinzon M. epsilonPKC phosphorylates the mitochondrial K(+) (ATP) channel during induction of ischemic preconditioning in the rat hippocampus. Brain Res. 2007;1184:345-53 pubmed
    ..Treatment with the K(+)(ATP) channel openers diazoxide or pinacidil 48 h prior to lethal ischemia protected hippocampal CA1 neurons, mimicking the induction of ..
  3. Yildizdas D, Erdem S, Kucukosmanoglu O, Yilmaz M, Yuksel B. Pulmonary hypertension, heart failure and neutropenia due to diazoxide therapy. Adv Ther. 2008;25:515-9 pubmed publisher
    ..b>Diazoxide treatment remains the mainstay of medical therapy...
  4. Quoix N, Cheng Xue R, Mattart L, Zeinoun Z, Guiot Y, Beauvois M, et al. Glucose and pharmacological modulators of ATP-sensitive K+ channels control [Ca2+]c by different mechanisms in isolated mouse alpha-cells. Diabetes. 2009;58:412-21 pubmed publisher
    ..alpha-Cell I(KATP) was inhibited by tolbutamide and activated by diazoxide or the mitochondrial poison azide, as in beta-cells...
  5. Kapoor R, Flanagan S, James C, Shield J, Ellard S, Hussain K. Hyperinsulinaemic hypoglycaemia. Arch Dis Child. 2009;94:450-7 pubmed publisher
    ..This review gives an outline of the clinical presentation, the diagnostic cascade, the underlying molecular mechanisms and the management of HH with a particular focus on congenital forms of hyperinsulinism. ..
  6. Nilakantan V, Liang H, Mortensen J, Taylor E, Johnson C. Variable effects of the mitoK(ATP) channel modulators diazoxide and 5-HD in ATP-depleted renal epithelial cells. Mol Cell Biochem. 2010;335:211-22 pubmed publisher
    ..In this study, we compared the effects of the putative mitoK(ATP) opener, diazoxide, and the mitoK(ATP) blocker, 5-hydroxydecanoate (5-HD) on cytotoxicity and apoptosis in tubular epithelial cells ..
  7. Bellanne Chantelot C, Saint Martin C, Ribeiro M, Vaury C, Verkarre V, Arnoux J, et al. ABCC8 and KCNJ11 molecular spectrum of 109 patients with diazoxide-unresponsive congenital hyperinsulinism. J Med Genet. 2010;47:752-9 pubmed publisher
    ..CHI patients are classified according to their responsiveness to diazoxide and to their histopathological diagnosis (either focal, diffuse or atypical forms)...
  8. Montero Luis C, Pozo Román J, Muñoz Calvo M, Martos Moreno G, Donoso M, Rubio Cabezas O, et al. [Hyperinsulinism-hyperammonemia syndrome due to a de novo mutation in exon 7 (G979A) of the glutamate dehydrogenase gene with excellent response to diazoxide]. An Pediatr (Barc). 2004;61:433-7 pubmed
    ..We present the case of a 16-month-old boy with symptomatic recurrent hypoglycemias from the end of the first year of life, caused by a de novo mutation in exon 7 (G979A) of the GDH gene, with excellent outcome after diazoxide treatment.
  9. Fedorov V, Glukhov A, Ambrosi C, Kostecki G, Chang R, Janks D, et al. Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts. J Mol Cell Cardiol. 2011;51:215-25 pubmed publisher
    This study compared the effects of ATP-regulated potassium channel (K(ATP)) openers, diazoxide and pinacidil, on diseased and normal human atria and ventricles...
  10. Alemzadeh R, Tushaus K. Modulation of adipoinsular axis in prediabetic zucker diabetic fatty rats by diazoxide. Endocrinology. 2004;145:5476-84 pubmed
    ..b>Diazoxide (DZ; 150 mg/kg...
  11. Silvani P, Camporesi A, Mandelli A, Wolfler A, Salvo I. A case of severe diazoxide toxicity. Paediatr Anaesth. 2004;14:607-9 pubmed
    ..Therapy can be accomplished either surgically or pharmacologically. Diazoxide treatment remains the mainstay of medical therapy...
  12. Szollosi A, Nenquin M, Henquin J. Pharmacological stimulation and inhibition of insulin secretion in mouse islets lacking ATP-sensitive K+ channels. Br J Pharmacol. 2010;159:669-77 pubmed publisher
    ..Neither K(ATP) channel opener (diazoxide, pinacidil) inhibited Sur1KO islets...
  13. Guo W, Ge D, Wang Q, Xu S, Xue L, Lu C, et al. Diazoxide decreases ischemia-reperfusion injury in a rat model of lung transplantation. Transplant Proc. 2011;43:2510-6 pubmed publisher
    ..Given a pivotal role of mitochondria in IRI-related molecular events, the effects of diazoxide, a selective opener of mitochondrial adenosine-5'-triphosphate (ATP)-sensitive potassium channels (mitoK(ATP)), ..
  14. Guo Z, Bu S, Yu Y, Ghatnekar G, Wang M, Chen L, et al. Diazoxide prevents abdominal adiposity and fatty liver in obese OLETF rats at prediabetic stage. J Diabetes Complications. 2008;22:46-55 pubmed publisher
    ..The objective of this study was to evaluate the effects of diazoxide, an inhibitor of glucose-stimulated insulin secretion, on the prevention of fat deposition in the liver and in ..
  15. Penna C, Perrelli M, Tullio F, Angotti C, Camporeale A, Poli V, et al. Diazoxide postconditioning induces mitochondrial protein S-nitrosylation and a redox-sensitive mitochondrial phosphorylation/translocation of RISK elements: no role for SAFE. Basic Res Cardiol. 2013;108:371 pubmed publisher
    ..either with brief cycles of ischemia/reperfusion (I-PostC) or with a direct targeting of mitochondria with Diazoxide (pharmacological PostC, P-PostC)...
  16. Domoki F, Bari F, Nagy K, Busija D, Siklos L. Diazoxide prevents mitochondrial swelling and Ca2+ accumulation in CA1 pyramidal cells after cerebral ischemia in newborn pigs. Brain Res. 2004;1019:97-104 pubmed
    b>Diazoxide (DIAZ), an opener of mitochondrial ATP-sensitive K(+) channels (mK(ATP)), protects neurons against hypoxic/ischemic stress in vivo, however, direct evidence showing mitochondrial effects of DIAZ in postischemic neurons is ..
  17. Andrukhiv A, Costa A, West I, Garlid K. Opening mitoKATP increases superoxide generation from complex I of the electron transport chain. Am J Physiol Heart Circ Physiol. 2006;291:H2067-74 pubmed
    ..When mitochondria were treated with the K(ATP) channel openers diazoxide or cromakalim, their ROS production increased by 40-50%, and this effect was blocked by 5-hydroxydecanoate...
  18. McCully J, Toyoda Y, Wakiyama H, Rousou A, Parker R, Levitsky S. Age- and gender-related differences in ischemia/reperfusion injury and cardioprotection: effects of diazoxide. Ann Thorac Surg. 2006;82:117-23 pubmed
    ..Cardioplegia +/- diazoxide was infused separately, 5 minutes before global ischemia...
  19. Xu B, Makris A, Thornton C, Ogle R, Horvath J, Hennessy A. Antihypertensive drugs clonidine, diazoxide, hydralazine and furosemide regulate the production of cytokines by placentas and peripheral blood mononuclear cells in normal pregnancy. J Hypertens. 2006;24:915-22 pubmed
    Antihypertensive drugs such as clonidine, diazoxide, hydralazine and furosemide are used in the hypertensive disorders of pregnancy to control blood pressure, but it is not clear if they modulate the production of placental or ..
  20. Farkas E, Timmer N, Domoki F, Mihaly A, Luiten P, Bari F. Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion. Neurosci Lett. 2005;387:168-72 pubmed
    b>Diazoxide is a putative mitochondrial, ATP-sensitive potassium channel opener that has been implicated in neuroprotection in cerebral ischemia...
  21. Farkas E, Institoris A, Domoki F, Mihaly A, Bari F. The effect of pre- and posttreatment with diazoxide on the early phase of chronic cerebral hypoperfusion in the rat. Brain Res. 2006;1087:168-74 pubmed
    b>Diazoxide has been identified as a mitochondrial, ATP-dependent K(+) channel opener, and a potentially neuroprotective compound under ischemic conditions...
  22. Henwood M, Kelly A, Macmullen C, Bhatia P, Ganguly A, Thornton P, et al. Genotype-phenotype correlations in children with congenital hyperinsulinism due to recessive mutations of the adenosine triphosphate-sensitive potassium channel genes. J Clin Endocrinol Metab. 2005;90:789-94 pubmed
    ..SUR1 delF1388, are null mutations yielding nonfunctional channels and are characterized by nonresponsiveness to diazoxide, a channel agonist, and absence of acute insulin responses (AIRs) to tolbutamide, a channel antagonist, or ..
  23. Nakagawa I, Wajima D, Tamura K, Nishimura F, Park Y, Nakase H. The neuroprotective effect of diazoxide is mediated by mitochondrial ATP-dependent potassium channels in a rat model of acute subdural hematoma. J Clin Neurosci. 2013;20:144-7 pubmed publisher
    ..pretreated intraventricularly 15 minutes before ASDH with (1) vehicle (n=10); (2) the mitoK(ATP) channel agonist diazoxide (n=9); (3) diazoxide plus the selective mitoK(ATP) channel antagonist 5-hydroxydecanoate (5-HD) (n=6); or (4) 5-..
  24. Eliseev R, Vanwinkle B, Rosier R, Gunter T. Diazoxide-mediated preconditioning against apoptosis involves activation of cAMP-response element-binding protein (CREB) and NFkappaB. J Biol Chem. 2004;279:46748-54 pubmed
    Treatment of various types of cells with the mitochondrial ATP-sensitive K+ channel opener, diazoxide, preconditions cells to subsequent injuries and inhibits apoptosis. The mechanism of such preconditioning is not well understood...
  25. Radtke M, Kollind M, Qvigstad E, Grill V. Twelve weeks' treatment with diazoxide without insulin supplementation in Type 2 diabetes is feasible but does not improve insulin secretion. Diabet Med. 2007;24:172-7 pubmed
    Treatment with K-ATP channel openers, such as diazoxide, can have beneficial effects on insulin secretion in both Type 1 and Type 2 diabetes...
  26. Naitoh K, Ichikawa Y, Miura T, Nakamura Y, Miki T, Ikeda Y, et al. MitoKATP channel activation suppresses gap junction permeability in the ischemic myocardium by an ERK-dependent mechanism. Cardiovasc Res. 2006;70:374-83 pubmed
    ..In isolated rabbit hearts, tissues were sampled before and after infusion of diazoxide, a selective mitoKATP channel opener, and their intercalated disc-rich fractions were obtained for ..
  27. Roth S, Dreixler J, Shaikh A, Lee K, Bindokas V. Mitochondrial potassium ATP channels and retinal ischemic preconditioning. Invest Ophthalmol Vis Sci. 2006;47:2114-24 pubmed
    ..IPC was effectively mimicked by injection of the mKATP channel opener diazoxide. Both IPC and its mimicking by diazoxide were completely attenuated by the mKATP channel blocker 5-..
  28. Sandler S, Andersson A, Larsson J, Makeeva N, Olsen T, Arkhammar P, et al. Possible role of an ischemic preconditioning-like response mechanism in K(ATP) channel opener-mediated protection against streptozotocin-induced suppression of rat pancreatic islet function. Biochem Pharmacol. 2008;76:1748-56 pubmed publisher
    ..KCOs with this property may be particularly interesting compounds to study as a rescue therapy during acute episodes of beta-cell suppression/destruction. ..
  29. Han J, Wang H, Yan D, Wang Z, Han H, Zhu H, et al. Myocardial ischaemic and diazoxide preconditioning both increase PGC-1alpha and reduce mitochondrial damage. Acta Cardiol. 2010;65:639-44 pubmed
    Pretreatment with diazoxide, a mitochondrial ATP-sensitive potassium channel (mito KATP) opener, was found to protect the rat heart against ischaemia-reperfusion (I/R) injury by mimicking ischaemic preconditioning (IPC)...
  30. Xia Y, Rajapurohitam V, Cook M, Karmazyn M. Inhibition of phenylephrine induced hypertrophy in rat neonatal cardiomyocytes by the mitochondrial KATP channel opener diazoxide. J Mol Cell Cardiol. 2004;37:1063-7 pubmed
    The effect of the putative mitochondrial K(ATP) channel opener diazoxide (100 microM) was studied in terms of its ability to modulate the hypertrophic effect of 24 h treatment with the alpha(1) adrenoceptor agonist phenylephrine (PE; 10 ..
  31. Jiang K, Gao F, Shui Q, Yu Z, Xia Z. Effect of diazoxide on regulation of vesicular and plasma membrane GABA transporter genes and proteins in hippocampus of rats subjected to picrotoxin-induced kindling. Neurosci Res. 2004;50:319-29 pubmed
    ..In this experiment, the effects of diazoxide (DIZ) on the VGAT, GAT-1 and GAT-3 mRNA and protein levels in hippocampus, and on the seizure activities of ..
  32. Mayanagi K, Gaspar T, Katakam P, Busija D. Systemic administration of diazoxide induces delayed preconditioning against transient focal cerebral ischemia in rats. Brain Res. 2007;1168:106-11 pubmed
    b>Diazoxide is the prototypical opener of mitochondrial ATP-sensitive potassium channels (mitoK(ATP)) and protects neurons in vivo and in vitro against chemical and anoxic stresses...
  33. Cui X, Wang H, Guo H, Wang C, Ao H, Liu X, et al. Transplantation of mesenchymal stem cells preconditioned with diazoxide, a mitochondrial ATP-sensitive potassium channel opener, promotes repair of myocardial infarction in rats. Tohoku J Exp Med. 2010;220:139-47 pubmed
    ..b>Diazoxide, a mitochondrial ATP-sensitive potassium channel opener, has been applied to suppress cell apoptosis and promote ..
  34. Patti M, McMahon G, Mun E, Bitton A, Holst J, Goldsmith J, et al. Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia. Diabetologia. 2005;48:2236-40 pubmed
    ..three patients with severe postprandial hypoglycaemia and hyperinsulinaemia unresponsive to diet, octreotide and diazoxide with the aim of elucidating the pathological mechanisms involved...
  35. Olsen H, Theander S, Bokvist K, Buschard K, Wollheim C, Gromada J. Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells. Endocrinology. 2005;146:4861-70 pubmed
    ..The effect of glucose was abolished by the KATP-channel opener diazoxide as well as by mannoheptulose and azide, inhibitors of glycolysis and mitochondrial metabolism...
  36. Sargsyan E, Ortsäter H, Thorn K, Bergsten P. Diazoxide-induced beta-cell rest reduces endoplasmic reticulum stress in lipotoxic beta-cells. J Endocrinol. 2008;199:41-50 pubmed publisher
    ..to further delineate mechanisms of how openers of K(ATP) channels improve beta-cell function, the effects of diazoxide on markers of endoplasmic reticulum (ER) stress was determined in beta-cells exposed to the fatty acid palmitate...
  37. Fafoula O, Alkhayyat H, Hussain K. Prolonged hyperinsulinaemic hypoglycaemia in newborns with intrauterine growth retardation. Arch Dis Child Fetal Neonatal Ed. 2006;91:F467 pubmed
  38. Ma Z, Portwood N, Brodin D, Grill V, Bjorklund A. Effects of diazoxide on gene expression in rat pancreatic islets are largely linked to elevated glucose and potentially serve to enhance beta-cell sensitivity. Diabetes. 2007;56:1095-106 pubmed
    b>Diazoxide enhances glucose-induced insulin secretion from beta-cells through mechanisms that are not fully elucidated. Here, we used microarray analysis (Affymetrix) to investigate effects of diazoxide...
  39. van Boekel G, Loves S, van Sorge A, Ruinemans Koerts J, Rijnders T, de Boer H. Weight loss in obese men by caloric restriction and high-dose diazoxide-mediated insulin suppression. Diabetes Obes Metab. 2008;10:1195-203 pubmed publisher
    To examine the concept whether high-dose diazoxide (DZX)-mediated insulin suppression, in combination with moderate caloric restriction and increased physical activity, can establish a weight loss of at least 15% in obese ..
  40. Pinney S, Macmullen C, Becker S, Lin Y, Hanna C, Thornton P, et al. Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations. J Clin Invest. 2008;118:2877-86 pubmed publisher
    ..3 years, and 15 of 16 were well controlled on diazoxide, a KATP channel agonist. Of 29 adults with mutations, 14 were asymptomatic...
  41. Ng B, Kang Y, Xie H, Sun H, Gaisano H. Syntaxin-1A inhibition of P-1075, cromakalim, and diazoxide actions on mouse cardiac ATP-sensitive potassium channel. Cardiovasc Res. 2008;80:365-74 pubmed publisher
    ..Here, we examined whether Syn-1A would influence non-specific (diazoxide) and SUR2-specific KCOs [N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridylguanidine (P-1075) and cromakalim] on ..
  42. Flanagan S, Kapoor R, Mali G, Cody D, Murphy N, Schwahn B, et al. Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations. Eur J Endocrinol. 2010;162:987-92 pubmed publisher
    The phenotype associated with heterozygous HNF4A gene mutations has recently been extended to include diazoxide responsive neonatal hypoglycemia in addition to maturity-onset diabetes of the young (MODY)...
  43. Zhang H, Zhao D, Wang Z, Zheng D. Diazoxide preconditioning alleviates caspase-dependent and caspase-independent apoptosis induced by anoxia-reoxygenation of PC12 cells. J Biochem. 2010;148:413-21 pubmed publisher
    ..We found that pre-treatment of PC12 cells with diazoxide (DZX), a mitochondrial ATP sensitive potassium channel (mitoK(ATP)) opener, dose-dependently increased cell ..
  44. Busija D, Katakam P, Rajapakse N, Kis B, Grover G, Domoki F, et al. Effects of ATP-sensitive potassium channel activators diazoxide and BMS-191095 on membrane potential and reactive oxygen species production in isolated piglet mitochondria. Brain Res Bull. 2005;66:85-90 pubmed
    ..b>Diazoxide and BMS-191095, putative selective openers of mitoK(ATP), decreased the mitochondrial membrane potential (delta ..
  45. Dröse S, Hanley P, Brandt U. Ambivalent effects of diazoxide on mitochondrial ROS production at respiratory chain complexes I and III. Biochim Biophys Acta. 2009;1790:558-65 pubmed publisher
    ..In a previous study we analyzed the mitochondrial effects of the efficient preconditioning drug diazoxide and found that it increased the mitochondrial oxidation of the ROS-sensitive fluorescent dye 2',7'-..
  46. Alemzadeh R, Karlstad M, Tushaus K, Buchholz M. Diazoxide enhances basal metabolic rate and fat oxidation in obese Zucker rats. Metabolism. 2008;57:1597-607 pubmed publisher
    Persistent suppression of hyperinsulinemia in genetically obese (fa/fa) Zucker rats by diazoxide (DZ) reduces food intake and weight gain; improves insulin sensitivity, glycemic control, and lipid profile; and enhances beta(3)-adrenergic ..
  47. Kim M, Kim M, Yoon I, Ahn J, Lee S, Baik E, et al. Diazoxide acts more as a PKC-epsilon activator, and indirectly activates the mitochondrial K(ATP) channel conferring cardioprotection against hypoxic injury. Br J Pharmacol. 2006;149:1059-70 pubmed
    b>Diazoxide, a well-known opener of the mitochondrial ATP-sensitive potassium (mitoK(ATP)) channel, has been demonstrated to exert cardioprotective effect against ischemic injury through the mitoK(ATP) channel and protein kinase C (PKC)...
  48. Riess M, Camara A, Heinen A, Eells J, Henry M, Stowe D. KATP channel openers have opposite effects on mitochondrial respiration under different energetic conditions. J Cardiovasc Pharmacol. 2008;51:483-91 pubmed publisher
    ..One of two mKATP channel openers, pinacidil or diazoxide, was given before adenosine diphosphate in the absence or presence of an mKATP channel antagonist, glibenclamide ..
  49. Henquin J, Nenquin M, Sempoux C, Guiot Y, Bellanne Chantelot C, Otonkoski T, et al. In vitro insulin secretion by pancreatic tissue from infants with diazoxide-resistant congenital hyperinsulinism deviates from model predictions. J Clin Invest. 2011;121:3932-42 pubmed publisher
    ..was consistently ineffective in stimulating insulin secretion; conversely, the KATP channel activator diazoxide often caused an unanticipated increase in insulin secretion...
  50. Sawada K, Morishige K, Hashimoto K, Tasaka K, Kurachi H, Murata Y, et al. Gestational change of K+ channel opener effect is correlated with the expression of uterine KATP channel subunits. Eur J Obstet Gynecol Reprod Biol. 2005;122:49-56 pubmed
  51. Chen Z, Cheng Y, Chen L, Cheng K, Li Y, Cheng J. Increase of ATP-sensitive potassium (K(ATP)) channels in the heart of type-1 diabetic rats. Cardiovasc Diabetol. 2012;11:8 pubmed publisher
    ..It is highly responsive to metabolic fluctuations and can have effects on cardiac contractility. The present study attempted to clarify the changes of cardiac K(ATP) channels in diabetic disorders...
  52. Minners J, Lacerda L, Yellon D, Opie L, McLeod C, Sack M. Diazoxide-induced respiratory inhibition - a putative mitochondrial K(ATP) channel independent mechanism of pharmacological preconditioning. Mol Cell Biochem. 2007;294:11-8 pubmed
    ..b>Diazoxide administration confers this cytoprotection, however, whether this is via direct activation of the putative ..
  53. Huang C, Wu S, Cheng J, Tsai J, Huang C. Diazoxide reduces status epilepticus neuron damage in diabetes. Neurotox Res. 2010;17:305-16 pubmed publisher
    ..Both groups were treated with either diazoxide (15 mg/kg, i.v...