Summary: A thiazide diuretic with properties similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830)

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  1. Takahashi Y, Nishida Y, Nakayama T, Asai S. Adverse effect profile of trichlormethiazide: a retrospective observational study. Cardiovasc Diabetol. 2011;10:45 pubmed publisher
    b>Trichlormethiazide, a thiazide diuretic, was introduced in 1960 and remains one of the most frequently used diuretics for treating hypertension in Japan. While numerous clinical trials have indicated important side effects of thiazides, e...
  2. Honda T, Hamada M, Shigematsu Y, Matsumoto Y, Matsuoka H, Hiwada K. Effect of antihypertensive therapy on aortic distensibility in patients with essential hypertension: comparison with trichlormethiazide, nicardipine and alacepril. Cardiovasc Drugs Ther. 1999;13:339-46 pubmed
    ..Thirty three hypertensive patients were divided into three groups and treated for 12 weeks with 2-4 mg trichlormethiazide per day (n = 10), 80 mg nicardipine per day (n = 13) and 50 mg alacepril per day (n = 10)...
  3. Hanawa T, Maeda R, Muramatsu E, Suzuki M, Sugihara M, Nakajima S. New oral dosage form for elderly patients. III. Stability of trichlormethiazide in silk fibroin gel and various sugar solutions. Drug Dev Ind Pharm. 2000;26:1091-7 pubmed
    The hydrolysis of trichlormethiazide (TCM) in silk fibroin gel (SFG) prepared in various sugar solutions (such as ribose, fructose, mannose, and glucose solutions) was determined...
  4. Shimizu T, Yoshitomi K, Nakamura M, Imai M. Site and mechanism of action of trichlormethiazide in rabbit distal nephron segments perfused in vitro. J Clin Invest. 1988;82:721-30 pubmed
    To determine the exact site and mechanism of action of thiazide diuretics, effects of 10(-4) M trichlormethiazide (TCM) on NaCl transport were examined in the distal convoluted tubule (DCT), the connecting tubule (CNT) and the cortical ..
  5. Ito O, Hasegawa Y, Sato K, Mitsui H, Yuda F, Sato H, et al. A case of exercise-induced acute renal failure in a patient with idiopathic renal hypouricemia developed during antihypertensive therapy with losartan and trichlormethiazide. Hypertens Res. 2003;26:509-13 pubmed
    ..acute renal failure (ARF) developed in a 45-year-old man during antihypertensive therapy with losartan and trichlormethiazide. The antihypertensive therapy was stopped and marked hypouricemia became apparent during improvement of his ..
  6. Ishimitsu T, Numabe A, Masuda T, Akabane T, Okamura A, Minami J, et al. Angiotensin-II receptor antagonist combined with calcium channel blocker or diuretic for essential hypertension. Hypertens Res. 2009;32:962-8 pubmed publisher 20 mg day(-1), were additionally given 8-16 mg day(-1) of the CCB azelnidipine or 1-2 mg day(-1) of trichlormethiazide (a thiazide diuretic) in a randomized crossover manner for 4 months each...
  7. Fujimura A, Shiga T, Kajiyama H, Ohashi K, Ebihara A. Chronopharmacology of trichlormethiazide in rats; (II). Examination in aged rats. Life Sci. 1991;49:931-7 pubmed
    We have previously demonstrated a time-dependent variability in the diuretic effects of trichlormethiazide, a thiazide diuretic agent, in young rats...
  8. Kuramoto K. Treatment of elderly hypertensives in Japan: National Intervention Cooperative Study in Elderly Hypertensives. The National Intervention Cooperative Study Group. J Hypertens Suppl. 1994;12:S35-40 pubmed
    ..of Elderly Hypertensives, a long-term study comparing the effects of a calcium antagonist (nicardipine) and a thiazide diuretic (trichlormethiazide) on cardiovascular complications in elderly patients with mild to moderate hypertension.
  9. Shionoiri H, Kosaka T, Kita E, Takizawa T, Takasaki I. Comparison of long-term therapeutic effect of an ACE inhibitor, temocapril, with that of a diuretic on microalbuminuria in non-diabetic essential hypertension. Hypertens Res. 2000;23:593-600 pubmed
    ..effect of temocapril with that of a diuretic on UAE, hypertensive patients treated with a diuretic (trichlormethiazide) were enrolled in a prospective study if they had normal serum creatinine levels and no overt proteinuria ..

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  1. Insogna K, Ellison A, Burtis W, Sartori L, Lang R, Broadus A. Trichlormethiazide and oral phosphate therapy in patients with absorptive hypercalciuria. J Urol. 1989;141:269-74 pubmed 36 patients with absorptive hypercalciuria were initially treated with diet alone followed by either trichlormethiazide (4 mg. per day) or oral neutral phosphate (1,500 mg. of elemental phosphorus per day) for 6 weeks...
  2. Ogawa S, Mori T, Nako K, Kato T, Takeuchi K, Ito S. Angiotensin II type 1 receptor blockers reduce urinary oxidative stress markers in hypertensive diabetic nephropathy. Hypertension. 2006;47:699-705 pubmed
    ..with nephropathy were randomly assigned to either the angiotensin II receptor blocker (ARB; n=33) or trichlormethiazide (n=33) group...
  3. Uzu T, Harada T, Namba T, Yamamoto R, Takahara K, Yamauchi A, et al. Thiazide diuretics enhance nocturnal blood pressure fall and reduce proteinuria in immunoglobulin A nephropathy treated with angiotensin II modulators. J Hypertens. 2005;23:861-5 pubmed
    ..5-3 g daily), and treatment with angiotensin II modulators were studied. The patients received a diuretic, trichlormethiazide (2 mg daily) for 4 weeks after a baseline period lasting for 4 weeks...
  4. Watari H. [Significance of brain renin for pathogenesis of hypertension: effect of antihypertensive drugs on active and inactive renins in the brain of spontaneously hypertensive rat]. Nihon Naibunpi Gakkai Zasshi. 1989;65:66-78 pubmed
    ..hypertensive rats (SHR) and Wistar-Kyoto rats (WKY); as controls (n = 5), administered captopril (n = 5), trichlormethiazide (n = 5) and atenolol (n = 5)...
  5. Takanohashi A, Tojo A, Kobayashi N, Yagi S, Matsuoka H. Effect of trichlormethiazide and captopril on nitric oxide synthase activity in the kidney of deoxycorticosterone acetate-salt hypertensive rats. Jpn Heart J. 1996;37:251-9 pubmed
    ..We have investigated the effect of trichlormethiazide and captopril on NO synthase (NOS) activity and glomerular damage in the kidney of deoxycorticosterone ..
  6. Iguchi M, Ikegami M, Kiwamoto H, Umekawa T, Ishikawa Y, Kohri K, et al. [Effect of verapamil on urinary calcium and oxalate excretion in renal stone formers]. Hinyokika Kiyo. 1993;39:425-31 pubmed
    ..calcium antagonist verapamil on urinary calcium and oxalate excretion was examined and compared with that of trichlormethiazide to evaluate whether verapamil is useful in the prevention of calcium oxalate renal stones...
  7. Kawashima K, Negishi T, Amano H, Fujimoto K, Suzuki T, Fujii T. Antihypertensive effects, determined by a telemetry method, of trichloromethiazide and 7-O-ethylfangchinoline, a derivative of tetrandrine, in spontaneously hypertensive rats. Clin Exp Pharmacol Physiol Suppl. 1995;22:S300-1 pubmed
    ..5. The results of the present study demonstrate that the telemetry method is useful for monitoring the antihypertensive effects of drugs in SHR under physiological conditions with minimal stress. ..
  8. Ogura T, Nishida N, Watanabe H, Omiya T, Yamauchi T, Hosoya M, et al. Alteration of renal receptors for atrial natriuretic peptide and vasopressin in spontaneously hypertensive rats treated with antihypertensive diuretics. Res Commun Chem Pathol Pharmacol. 1994;83:165-78 pubmed
    ..This indicates that the ANP and AVP receptor in the kidney of SHR was changed not only by diuresis or reduction of blood pressure, but by the pharmacological action of indapamide. ..
  9. Goto T, Mikami E, Ohno T, Matsumoto H. [Simultaneous analysis of four diuretic drugs by HPLC and its application to health food supplements advertising weight reduction]. Shokuhin Eiseigaku Zasshi. 2002;43:95-8 pubmed
    A high-performance liquid chromatographic (HPLC) method for the simultaneous analysis of triamterene, trichlormethiazide, furosemide and spironolactone is presented for application in the examination of health food supplements advertising ..
  10. Kimura K, Tojo A, Matsuoka H, Sugimoto T. Renal arteriolar diameters in spontaneously hypertensive rats. Vascular cast study. Hypertension. 1991;18:101-10 pubmed
    ..rats 4 weeks of age were divided into three groups: nontreated, captopril (40 mg/kg/day)-treated, and trichlormethiazide (1 mg/kg/day) with hydralazine (20 mg/kg/day)-treated. Wistar-Kyoto rats served as controls...
  11. Kim S, Hamaguchi A, Shinkawa T, Kato Y, Tsuchiya N, Miura K, et al. Molecular effects of M17055, furosemide and thiazide on cardiac hypertrophy of spontaneously hypertensive rats. J Pharmacol Exp Ther. 1996;279:983-90 pubmed
    ..o. M17055 (a novel "high ceiling" diuretic) 1.25, 2.5 or 5 mg/kg/day, furosemide 50 mg/kg/day or trichlormethiazide 30 mg/kg/day for 5 weeks...
  12. Ichihara K, Okumura K, Kamei H, Nagasaka M, Kanda A, Kanno T, et al. Renal effects of the calcium channel blocker aranidipine and its active metabolite in anesthetized dogs and conscious spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1998;31:277-85 pubmed
    ..The metabolite of aranidipine may contribute, in part, to the diuretic, natriuretic, and antihypertensive effects of aranidipine. ..
  13. Kahonen M, Mäkynen H, Arvola P, Wuorela H, Porsti I. Arterial function after trichlormethiazide therapy in spontaneously hypertensive rats. J Pharmacol Exp Ther. 1995;272:1223-30 pubmed the long-term influences of diuretic therapy on arterial function remain largely unknown, the effects of trichlormethiazide (8 mg kg-1 day-1) on vascular responses were studied in spontaneously hypertensive rats (SHR) and ..
  14. Yamagata T, Kobayashi T, Kusaka H, Karasawa A. Diuretic effects of KW-3902, a novel adenosine A1-receptor antagonist, in anesthetized dogs. Biol Pharm Bull. 1994;17:1599-603 pubmed
    ..b>Trichlormethiazide at 3 micrograms/kg/min for 20 min also provoked increases in urine volume and sodium excretion, but did not ..
  15. Ohnishi K, Kohno M, Yukiiri K, Masugata H, Wada Y, Takagi Y, et al. Influence of the angiotensin II receptor antagonist losartan on diuretic-induced metabolic effects in elderly hypertensive patients: comparison with a calcium channel blocker. Int J Clin Pharmacol Ther. 2001;39:417-22 pubmed
    ..Diuretic therapy included low-dose trichlormethiazide or low-dose furosemide in numbers of patients that were similar between L+D and N+D groups...
  16. Kusaka H, Nagashima K, Karasawa A. Effects of KW-3902, an adenosine A1-receptor antagonist, on ascites volume in puromycin aminonucleoside (PAN)-induced nephrotic rats. Jpn J Pharmacol. 1995;68:213-6 pubmed
    ..diuretic effects and reduced the volume of ascites, as was the case with furosemide (30 mg/kg/day) and trichlormethiazide (1 mg/kg/day)...
  17. Kobayashi A, Hayashi H, Kisamori K, Ishizaka K, Yamazaki N. Crossover trial comparison of enalapril maleate and trichlormethiazide in the treatment of essential hypertension: emphasis on the quality of life. Intern Med. 1992;31:165-73 pubmed
    Enalapril and trichlormethiazide were compared with respect to effects on the quality of life in a crossover study of 36 patients with hypertension...
  18. Uzu T, Takahara K, Yamauchi A. Change in the circadian rhythm of blood pressure in pseudo-hypoaldosteronism type 2 in response to thiazide diuretics. Clin Nephrol. 2004;61:367-8 pubmed
  19. Menuz K, Stroud R, Nicoll R, Hays F. TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists. Science. 2007;318:815-7 pubmed
    ..Our results demonstrate that the presence of an auxiliary subunit can determine whether a compound functions as an agonist or antagonist. ..
  20. Takami T. Evaluation of arterial stiffness in morning hypertension under high-dose valsartan compared to valsartan plus low-dose diuretic. Hypertens Res. 2009;32:1086-90 pubmed publisher
    ..were randomly assigned to receive 160 mg valsartan (V group, n=22) or 80 mg valsartan plus low-dose trichlormethiazide (1 mg) (V+D group, n=21) for 6 months...
  21. Kuwajima I, Kuramoto K, Ogihara T, Iimura O, Abe K, Saruta T, et al. Tolerability and safety of a calcium channel blocker in comparison with a diuretic in the treatment of elderly patients with hypertension: secondary analysis of the NICS-EH. Hypertens Res. 2001;24:475-80 pubmed
    ..calcium channel blocker nicardipine on the cardiovascular endpoint was similar to that of the diuretic, trichlormethiazide. The present report is a sub-analysis in which we compare the tolerability and safety of the calcium channel ..
  22. Ballew J, Fink G. Characterization of the antihypertensive effect of a thiazide diuretic in angiotensin II-induced hypertension. J Hypertens. 2001;19:1601-6 pubmed
    ..b>Trichlormethiazide (TCM), a thiazide diuretic, was orally administered, approximately 10 mg/kg per day, for the middle 5 days ..
  23. Mizuno H, Fujimoto S, Sugiyama Y, Kobayashi M, Ohro Y, Uchida S, et al. Successful treatment of partial nephrogenic diabetes insipidus with thiazide and desmopressin. Horm Res. 2003;59:297-300 pubmed
    ..However, combination treatment resulted in a decrease in urinary volume and the disappearance of nocturia. DDAVP coupled with thiazide may be useful for CNDI in patients who have shown a partial response to DDAVP. ..
  24. Yutaka M, Mifune M, Kubota E, Itoh H, Saito I. Comparison of effects of low dose of spironolactone and a thiazide diuretic in patients with hypertension treated with an angiotensin-converting enzyme inhibitor or an angiotensin type 1 receptor blocker. Clin Exp Hypertens. 2009;31:648-56 pubmed publisher
    ..performed to investigate the additional anti-hypertensive effects and safety of low-dose thiazide diuretic, trichlormethiazide (TCTZ), and a mineralocorticoid receptor blocker, spironolactone (SPI), as add-on therapy in 64 patients ..
  25. Doi M, Miyoshi T, Hirohata S, Kamikawa S, Usui S, Kaji Y, et al. Combination therapy of calcium channel blocker and angiotensin II receptor blocker reduces augmentation index in hypertensive patients. Am J Med Sci. 2010;339:433-9 pubmed publisher
    ..with ARBs were randomly allocated to either of the 2 groups receiving an ARB plus azelnidipine (AZ group) or trichlormethiazide (TCM group)...
  26. Sasaki J, Tominaga K, Saeki Y, Kawasaki K, Sumida I, Ikeda K, et al. Effects of lisinopril and low-dose trichlormethiazide on lipoprotein metabolism in patients with mild to moderate hypertension. J Hum Hypertens. 1992;6:233-7 pubmed a 12 week, randomised, multicentre trial to compare the effects of lisinopril (n = 31) and low-dose trichlormethiazide (n = 25) administration on blood pressure and lipoprotein metabolism...
  27. Matsushita K, Tanikawa K, Masuda A, Matsunaga J, Matsuzaki S. Treatment of bilateral urolithiasis. Tokai J Exp Clin Med. 1992;17:167-71 pubmed
  28. Ulvi V, Keski Hynnilä H. First-derivative UV spectrophotometric and high-performance liquid chromatographic analysis of some thiazide diuretics in the presence of their photodecomposition products. J Pharm Biomed Anal. 1994;12:917-22 pubmed
    Ethanolic solutions of three thiazide diuretics, chlorothiazide, hydrochlorothiazide and trichlormethiazide, were irradiated with a high-pressure mercury lamp...
  29. Suzuki H, Tominaga T, Kumagai H, Saruta T. Effects of first-line antihypertensive agents on sexual function and sex hormones. J Hypertens Suppl. 1988;6:S649-51 pubmed
    ..Our findings show that first-line antihypertensive agents have different effects on sexual function and that only captopril may have some advantages over the other agents in terms of the quality of sexual life. ..
  30. Ichikawa M, Wanaka M, Ohtsuji T, Akashi S, Machidera Y, Manno K, et al. Antihypertensive effects of a novel calcium antagonist, semotiadil fumarate (SD-3211), alone and in combination with enalapril or trichlormethiazide in spontaneously hypertensive rats. Biol Pharm Bull. 1994;17:1513-5 pubmed
    ..a novel benzothiazine calcium antagonist, was given alone or in combination with either enalapril or trichlormethiazide to conscious, spontaneously hypertensive, rats daily for 2 weeks...
  31. Ogihara T, Kuramoto K. Effect of long-term treatment with antihypertensive drugs on quality of life of elderly patients with hypertension: a double-blind comparative study between a calcium antagonist and a diuretic. NICS-EH Study Group. National Intervention Cooperative S. Hypertens Res. 2000;23:33-7 pubmed
    ..of long-term treatment with a calcium antagonist (nicardipine hydrochloride retard tablet) and a diuretic (trichlormethiazide) on quality of life (QOL) in elderly hypertensives in a multicenter, randomized, double-blind, comparative ..
  32. Miura K, Sekine T, Iida A, Takahashi K, Igarashi T. Salt-losing nephrogenic diabetes insipidus caused by fetal exposure to angiotensin receptor blocker. Pediatr Nephrol. 2009;24:1235-8 pubmed publisher
    ..ACEIs/ARBs must not be administered to pregnant women...
  33. Yu Y, Fukuda N, Yao E, Matsumoto T, Kobayashi N, Suzuki R, et al. Effects of an ARB on endothelial progenitor cell function and cardiovascular oxidation in hypertension. Am J Hypertens. 2008;21:72-7 pubmed
    ..Salt-loaded SHR-SP were treated with candesartan (1 mg/kg/day), a diuretic (trichlormethiazide, TCM, 1.6 mg/kg/day), or an antioxidant (tempol, 5 mg/kg/day) for 2 weeks...
  34. Katsumata H, Suzuki H, Ohishi A, Nakamoto H, Saruta T, Sakaguchi H. Effects of antihypertensive agents on blood pressure and the progress of renal failure in partially nephrectomized spontaneously hypertensive rats. Lab Invest. 1990;62:474-80 pubmed
    ..5/6 nephrectomy were divided into 4 groups: a control group (N = 8), and group treated with 10 mg/kg/day trichlormethiazide. (N = 8), 30 mg/kg/day captopril (N = 8), and 200 mg/kg/day nicardipine (N = 8)...
  35. Mizuno H, Sugiyama Y, Ohro Y, Imamine H, Kobayashi M, Sasaki S, et al. Clinical characteristics of eight patients with congenital nephrogenic diabetes insipidus. Endocrine. 2004;24:55-9 pubmed
    ..In six cases, we found abnormalities in the V2 receptor gene. Initially, trichlormethiazide therapy was shown to have a significant effect on polyuria; however, this effect decreased over time...
  36. Numabe A, Uehara Y, Hirawa N, Takada S, Yagi S. Effects of thiazide diuretic on vascular eicosanoid system of spontaneously hypertensive rats. J Hypertens. 1989;7:493-9 pubmed
  37. Takahashi N, Kondo Y, Fujiwara I, Ito O, Igarashi Y, Abe K. Characterization of Na+ transport across the cell membranes of the ascending thin limb of Henle's loop. Kidney Int. 1995;47:789-94 pubmed
    ..1 mM 5-(N,N-dimethyl)-amiloride (DMA), 0.1 mM furosemide, or 0.1 mM trichlormethiazide to the lumen did not change [Na+]i or the rate of change in [Na+]i/dt) after removal and replacement of ..
  38. Wiedme S, Riekkola M, Tenhu H. Interactions of diuretics with a neutral temperature-responsive polymer: study by capillary electroporesis and dynamic light scattering. J Capill Electrophor Microchip Technol. 1999;6:163-8 pubmed
    ..Among the diuretics studied, hydrochlorothiazide was detected to bind to PNIPA-g-PEO. ..
  39. Sasaguri M, Noda K, Tashiro E, Notomo J, Tsuji E, Koga M, et al. The regression of left ventricular hypertrophy by imidapril and the reduction of serum procollagen type III amino-terminal peptide in hypertensive patients. Hypertens Res. 2000;23:317-22 pubmed
    ..The starting dose of imidapril was 5 mg, and this was increased to 10 mg. Finally, 1 mg of trichlormethiazide was added to obtain adequate control of blood pressure...
  40. Shimizu T, Miyata K, Nakamura M. Effect of S-8666 on urinary Ca++ excretion in rats. J Pharmacol Exp Ther. 1989;250:654-8 pubmed
    ..Oral administration of S-8666 (3.2-316 mg/kg), furosemide (10-316 mg/kg) and trichlormethiazide (TCM; 0.01-10 mg/kg) caused natriuresis in a dose-dependent manner...
  41. Sato K, Dohi Y, Kojima M, Takase H, Suzuki S, Ito S. Antioxidative effects of thiazide diuretics in refractory hypertensive patients. A randomized crossover trial of chlortalidone and trichlormethiazide. Arzneimittelforschung. 2010;60:612-6 pubmed
    ..5 mg/day) and another thiazide diuretic, trichlormethiazide (CAS 133-67-5; 1 mg/day) was studied...
  42. Huonker M, Sorichter S, Schmidt Trucksass A, Irmer M, Staiger J, Keul J. Effectiveness of digitoxin versus trichlormethiazide/amiloride in congestive heart failure NYHA class II/III and sinus rhythm. Cardiovasc Drugs Ther. 1999;13:233-41 pubmed
    ..and then were randomly allocated, double blind, to take either digitoxin (digitalis group, DI: N = 8) or trichlormethiazide/amiloride (diuretic group, DG: N = 8) for 3 weeks (VP I)...
  43. Shimizu T, Nakamura M, Imai M. Effect of S-8666 on Cl- transport in the rabbit connecting tubule perfused in vitro. Tohoku J Exp Med. 1991;164:293-8 pubmed
    ..acts on the connecting tubule cell, the target of thiazide diuretics, we compared effects of S-8666 and trichlormethiazide on the basolateral membrane voltage of the connecting tubule cell...
  44. Ishii R, Tagawa T, Ishida T, Naruse T. Antihypertensive effects of a new transdermal delivery system for clonidine in genetic and experimental hypertensive rats. Arzneimittelforschung. 1996;46:261-8 pubmed
  45. Shimizu T, Nakamura M, Yoshitomi K, Imai M. Interaction of trichlormethiazide or amiloride with PTH in stimulating Ca2+ absorption in rabbit CNT. Am J Physiol. 1991;261:F36-43 pubmed
    ..The intact Na(+)-Ca2+ antiporter in the basolateral cell membrane is essential for the anticalciuric effect of thiazides and amiloride. ..
  46. Imamura T, Kinugawa K, Kato N, Minatsuki S, Muraoka H, Inaba T, et al. Successful conversion from thiazide to tolvaptan in a patient with stage d heart failure and chronic kidney disease before heart transplantation. Int Heart J. 2013;54:48-50 pubmed
    ..We experienced a stage D heart failure patient with CKD and hyponatremia who was switched from trichlormethiazide to tolvaptan...
  47. Fujimura A, Ohashi K, Ebihara A. Chronotherapy of trichlormethiazide in hypertensive patients. J Clin Pharmacol. 1991;31:54-7 pubmed
    Circadian influence of trichlormethiazide on serum electrolyte levels, lipid levels, and glucose levels were evaluated in 12 hypertensive patients...
  48. Temperini C, Cecchi A, Scozzafava A, Supuran C. Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference. Bioorg Med Chem. 2009;17:1214-21 pubmed publisher
    ..The newly evidenced binding modes of these diuretics may be exploited for designing better CA II inhibitors as well as compounds with selectivity/affinity for various isoforms with medicinal chemistry applications. ..
  49. Hatch M, Vaziri N. Do thiazides reduce intestinal oxalate absorption?: a study in vitro using rabbit colon. Clin Sci (Lond). 1994;86:353-7 pubmed
    ..2. The net absorptive flux of oxalate across the distal colon was significantly reduced in the presence of trichlormethiazide at 10(-4) mol/l...
  50. Iguchi M, Umekawa T, Ishikawa Y, Katayama Y, Kodama M, Takada M, et al. Clinical effects of prophylactic dietary treatment on renal stones. J Urol. 1990;144:229-32 pubmed
    ..From these results we conclude that individual dietary management should be the primary measure for the prophylaxis of renal stone disease in Japan. ..
  51. Yao K, Kusaka H, Sato K, Karasawa A. Protective effects of KW-3902, a novel adenosine A1-receptor antagonist, against gentamicin-induced acute renal failure in rats. Jpn J Pharmacol. 1994;65:167-70 pubmed
    ..In contrast, furosemide and trichlormethiazide aggravated the GM-induced nephrotoxicity...
  52. Kohri K, Kodama M, Katayama Y, Ishikawa Y, Takada M, Kataoka K, et al. Allopurinol and thiazide effects on new urinary stone formed after discontinued therapy in patients with urinary stones. Urology. 1990;36:309-14 pubmed
    ..However, allopurinol therapy was effective in preventing recurrence in patients with hyperuricosuria. ..
  53. Yoshioka S, Aso Y, Terao T. Effect of water mobility on drug hydrolysis rates in gelatin gels. Pharm Res. 1992;9:607-12 pubmed
    ..b>Trichlormethiazide hydrolysis and kanamycin-catalyzed flomoxef hydrolysis in gelatin gels were chosen as models for apparent ..