benzolamide

Summary

Summary: Selective renal carbonic anhydrase inhibitor. It may also be of use in certain cases of respiratory failure.

Top Publications

  1. Wetzel P, Hasse A, Papadopoulos S, Voipio J, Kaila K, Gros G. Extracellular carbonic anhydrase activity facilitates lactic acid transport in rat skeletal muscle fibres. J Physiol. 2001;531:743-56 pubmed
    ..2. Muscle fibres were exposed to 20 mM sodium lactate in the absence and presence of the CA inhibitors benzolamide (BZ), acetazolamide (AZ), chlorzolamide (CZ) and ethoxzolamide (EZ)...
  2. Hashimoto S, Huang Y, Castrop H, Hansen P, Mizel D, Briggs J, et al. Effect of carbonic anhydrase inhibition on GFR and renal hemodynamics in adenosine-1 receptor-deficient mice. Pflugers Arch. 2004;448:621-8 pubmed
    ..We determined the effect of the CA inhibitor benzolamide (Bz) on renal hemodynamics in adenosine-1 receptor (A1AR) knockout mice that have been shown previously to lack ..
  3. Bar Ilan A, Pessah N. The effects of topical and general anesthesia on ocular drug levels and intraocular pressure lowering activity of topically applied carbonic anhydrase inhibitors. J Ocul Pharmacol. 1988;4:1-12 pubmed
    ..rabbits significantly increased the permeability of the lipophobic carbonic anhydrase inhibitor (CAI) benzolamide (B) and transformed it to a highly active ocular hypotensive drug...
  4. Makani S, Chesler M. Endogenous alkaline transients boost postsynaptic NMDA receptor responses in hippocampal CA1 pyramidal neurons. J Neurosci. 2007;27:7438-46 pubmed
    ..blocker methoxyverapamil hydrochloride but was absent in the presence of the carbonic anhydrase inhibitor benzolamide or when the exogenous enzyme was heat inactivated...
  5. Höhne C, Pickerodt P, Francis R, Boemke W, Swenson E. Pulmonary vasodilation by acetazolamide during hypoxia is unrelated to carbonic anhydrase inhibition. Am J Physiol Lung Cell Mol Physiol. 2007;292:L178-84 pubmed
    ..kg(-1).h(-1)), 3) oral acetazolamide (5 mg/kg), 4) benzolamide, a membrane-impermeant inhibitor, and 5) ethoxzolamide, a membrane-permeant inhibitor...
  6. Cardenas V, Heming T, Bidani A. Kinetics of CO2 excretion and intravascular pH disequilibria during carbonic anhydrase inhibition. J Appl Physiol (1985). 1998;84:683-94 pubmed
    ..The shape of the hysteresis loops was affected by the extent of Actz inhibition of CA in red blood cells and plasma. ..
  7. Eminoğlu A, Vullo D, Aşık A, Çolak D, Çanakçı S, Beldüz A, et al. Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13. Bioorg Med Chem Lett. 2016;26:1821-6 pubmed publisher
    ..7-96.5nM). Clinically used agents such as methazolamide, ethoxzolamide, dorzolamide, brinzolamide, benzolamide, zonisamide, sulthiame, sulpiride, topiramate and valdecoxib were slightly less effective inhibitors (KIs in ..
  8. Taira T, Paalasmaa P, Voipio J, Kaila K. Relative contributions of excitatory and inhibitory neuronal activity to alkaline transients evoked by stimulation of Schaffer collaterals in the rat hippocampal slice. J Neurophysiol. 1995;74:643-9 pubmed
    ..In the absence of the drug, inhibition of extracellular carbonic anhydrase (CAo) by benzolamide or by prontosildextran 5000 (PD 5000) resulted in an increase in the alkaline shifts...
  9. Miracle C, Rieg T, Blantz R, Vallon V, Thomson S. Combined effects of carbonic anhydrase inhibitor and adenosine A1 receptor antagonist on hemodynamic and tubular function in the kidney. Kidney Blood Press Res. 2007;30:388-99 pubmed
    ..3 mg/kg i.v.) would prevent CAI (benzolamide 5 mg/kg i.v...

More Information

Publications62

  1. Del Prete S, Vullo D, Di Fonzo P, Osman S, Alothman Z, Donald W, et al. Sulfonamide inhibition profile of the ?-carbonic anhydrase identified in the genome of the pathogenic bacterium Burkholderia pseudomallei the etiological agent responsible of melioidosis. Bioorg Med Chem Lett. 2017;27:490-495 pubmed publisher
    ..The inhibition constant value for this enzyme for 39 sulfonamide inhibitors was obtained. Acetazolamide, benzolamide and metanilamide were the most effective (KIs of 149-653nM) inhibitors of BpsCA? activity, whereas ..
  2. Sun X, Li J, Cui M, Bonanno J. Role of carbonic anhydrase IV in corneal endothelial HCO3- transport. Invest Ophthalmol Vis Sci. 2008;49:1048-55 pubmed publisher
    ..Apical CAIV was inhibited by benzolamide or siRNA knockdown of CAIV...
  3. Tong C, Chesler M. Modulation of spreading depression by changes in extracellular pH. J Neurophysiol. 2000;84:2449-57 pubmed
    ..In addition, a carbonic anhydrase inhibitor (benzolamide) was used to decrease buffering of the alkaline shift to investigate its role in the modulation of SD...
  4. Deng A, Wead L, Blantz R. Temporal adaptation of tubuloglomerular feedback: effects of COX-2. Kidney Int. 2004;66:2348-53 pubmed
    ..Kidney blood flow (RBF) and glomerular filtration rate (GFR) were measured before and during benzolamide (BNZ) infusion in control Wistar rats and rats concurrently receiving COX-2 inhibitors...
  5. Svichar N, Waheed A, Sly W, Hennings J, Hübner C, Chesler M. Carbonic anhydrases CA4 and CA14 both enhance AE3-mediated Cl--HCO3- exchange in hippocampal neurons. J Neurosci. 2009;29:3252-8 pubmed publisher
    ..alkalinization was enhanced when the extracellular CAs were inhibited by the poorly permeant CA blocker, benzolamide, or by inhibitory antibodies specific for either CA4 or CA14...
  6. Teppema L, Berkenbosch A, Degoede J, Olievier C. Carbonic anhydrase and control of breathing: different effects of benzolamide and methazolamide in the anaesthetized cat. J Physiol. 1995;488 ( Pt 3):767-77 pubmed
    ..of inhibition of erythrocyte carbonic anhydrase on the ventilatory response to CO2 was studied by administering benzolamide (70 mg kg-1, i.v...
  7. Zhang Y, Mircheff A, Hensley C, Magyar C, Warnock D, Chambrey R, et al. Rapid redistribution and inhibition of renal sodium transporters during acute pressure natriuresis. Am J Physiol. 1996;270:F1004-14 pubmed
    ..internalization occurred when PT Na+ reabsorption was inhibited with the carbonic anhydrase inhibitor benzolamide. Five minutes after initiating either natriuretic stimuli, cortex was removed, and membranes were fractionated ..
  8. Casini A, Scozzafava A, Mincione F, Menabuoni L, Starnotti M, Supuran C. Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide. Bioorg Med Chem Lett. 2003;13:2867-73 pubmed
    ..afforded two series of benzolamide analogues to which the carboxyl moiety has been derivatized as esters or amides, in order to reduce their very ..
  9. Lamsa K, Kaila K. Ionic mechanisms of spontaneous GABAergic events in rat hippocampal slices exposed to 4-aminopyridine. J Neurophysiol. 1997;78:2582-91 pubmed
    ..Exposure to inhibitors of carbonic anhydrase, benzolamide (BA; 10 micro M) or ethoxyzolamide (EZA; 50 mu M) fully blocked the alkaline pHo transients and turned them ..
  10. Saarikoski J, Kaila K. Simultaneous measurement of intracellular and extracellular carbonic anhydrase activity in intact muscle fibres. Pflugers Arch. 1992;421:357-63 pubmed
    ..5-0.8 pH units) transient increase in pHs. Submicromolar concentrations of acetazolamide (AA) and benzolamide (BA) immediately blocked the pHs transients...
  11. Tong C, Cammer W, Chesler M. Activity-dependent pH shifts in hippocampal slices from normal and carbonic anhydrase II-deficient mice. Glia. 2000;31:125-30 pubmed
    ..09 +/- 0.04 and 0.08 +/- 0.04 unit pH, respectively. Addition of 1.5 microM benzolamide amplified the alkaline shifts by 385 +/- 146 and 345 +/- 75% in the mutant and wild-type preparations, ..
  12. Cincinelli A, Martellini T, Vullo D, Supuran C. Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus. Bioorg Med Chem Lett. 2015;25:5485-9 pubmed publisher
    ..Many clinically used drugs, such as acetazolamide, methazolamide, dorzolamide, brinzolamide, topiramate and benzolamide were low nanomolar inhibitors, with KIs in the range of 39.1-77.6 nM...
  13. Chandrashekar J, Yarmolinsky D, von Buchholtz L, Oka Y, Sly W, Ryba N, et al. The taste of carbonation. Science. 2009;326:443-5 pubmed publisher
    ..Together, these studies reveal the basis of the taste of carbonation as well as the contribution of taste cells in the orosensory response to CO2. ..
  14. Swenson E, Leatham K, Roach R, Schoene R, Mills W, Hackett P. Renal carbonic anhydrase inhibition reduces high altitude sleep periodic breathing. Respir Physiol. 1991;86:333-43 pubmed
    ..We studied benzolamide (3 mg/kg), a selective inhibitor of renal CA, in 4 climbers on ventilation and ventilatory responses at sea ..
  15. Paalasmaa P, Kaila K. Role of voltage-gated calcium channels in the generation of activity-induced extracellular pH transients in the rat hippocampal slice. J Neurophysiol. 1996;75:2354-60 pubmed
    ..The present results indicate that much (in s. pyramidale perhaps all) of the pH-changing influx of Ca2+ is mediated by voltage-gated Ca2+ channels. ..
  16. Svichar N, Esquenazi S, Waheed A, Sly W, Chesler M. Functional demonstration of surface carbonic anhydrase IV activity on rat astrocytes. Glia. 2006;53:241-7 pubmed
    ..Prior work showed that the intracellular lactate-induced acidification (LIA) of astrocytes is diminished by benzolamide, a poorly permeant, nonspecific CA inhibitor...
  17. Deng A, Hammes J, Thomson S. Hemodynamics of early tubuloglomerular feedback resetting during reduced proximal reabsorption. Kidney Int. 2002;62:2136-43 pubmed
    Carbonic anhydrase inhibition with benzolamide reduces proximal reabsorption and activates tubuloglomerular feedback (TGF)...
  18. Wetzel P, Papadopoulos S, Gros G. Inhibition of muscle carbonic anhydrase increases rise and relaxation times of twitches in rat skeletal muscle fibres. Pflugers Arch. 2002;443:762-70 pubmed
    ..The poorly membrane-permeable inhibitors benzolamide (BZ) and acetazolamide (ACTZ) had no effects on single twitches...
  19. Hempleman S, Rodriguez T, Bhagat Y, Begay R. Benzolamide, acetazolamide, and signal transduction in avian intrapulmonary chemoreceptors. Am J Physiol Regul Integr Comp Physiol. 2000;279:R1988-95 pubmed
    ..CA inhibitor that is membrane permeable (iv acetazolamide) with one that is relatively membrane impermeable (iv benzolamide)...
  20. Thomson S, Vallon V, Blantz R. Reduced proximal reabsorption resets tubuloglomerular feedback in euvolemic rats. Am J Physiol. 1997;273:R1414-20 pubmed
    ..to test for TGF resetting in free-flowing nephrons during systemic infusion of the carbonic anhydrase inhibitor benzolamide (BNZ, 5 mg x kg(-1) x h(-1)) in euvolemic rats...
  21. Vullo D, Del Prete S, Di Fonzo P, Carginale V, Donald W, Supuran C, et al. Comparison of the Sulfonamide Inhibition Profiles of the β- and γ-Carbonic Anhydrases from the Pathogenic Bacterium Burkholderia pseudomallei. Molecules. 2017;22: pubmed publisher
    ..The best inhibition was observed with benzene-1,3-disulfonamides-benzolamide and its analogs acetazolamide and methazolamide-which showed KI in the range of 185-745 nM...
  22. Cecchi A, Winum J, Innocenti A, Vullo D, Montero J, Scozzafava A, et al. Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide. Bioorg Med Chem Lett. 2004;14:5775-80 pubmed
    A series of sulfonamides incorporating 4-thioureido-benzolamide moieties have been prepared from aminobenzolamide and thiophosgene followed by the reaction of the thiocyanato intermediate with aliphatic/aromatic amines or hydrazines...
  23. Schneider H, Alt M, Klier M, Spiess A, Andes F, Waheed A, et al. GPI-anchored carbonic anhydrase IV displays both intra- and extracellular activity in cRNA-injected oocytes and in mouse neurons. Proc Natl Acad Sci U S A. 2013;110:1494-9 pubmed publisher
    ..Extra- and intracellular catalytic activity of CA IV could be pharmacologically dissected using benzolamide, the CA inhibitor, which is relatively slowly membrane-permeable...
  24. Tong C, Chesler M. Endogenous pH shifts facilitate spreading depression by effect on NMDA receptors. J Neurophysiol. 1999;81:1988-91 pubmed
    ..To test whether these endogenous pH shifts can modulate SD, the alkaline shift was amplified using benzolamide, a poorly permeant inhibitor of interstitial carbonic anhydrase. SD was evoked by microinjection of 1...
  25. Tong C, Brion L, Suarez C, Chesler M. Interstitial carbonic anhydrase (CA) activity in brain is attributable to membrane-bound CA type IV. J Neurosci. 2000;20:8247-53 pubmed
    ..The effect of benzolamide (a poorly permeant CA inhibitor) on evoked pH(o) shifts was diminished greatly in the PI-PLC-treated tissue, ..
  26. Tong C, Chesler M. Activity-evoked extracellular pH shifts in slices of rat dorsal lateral geniculate nucleus. Brain Res. 1999;815:373-81 pubmed
    ..02 pH units. The alkaline shift in the dLGN increased in the presence of benzolamide (1-2 microM), an extracellular carbonic anhydrase inhibitor. The mean alkaline shift in benzolamide was 0...
  27. Perry S, Gilmour K, Bernier N, Wood C. Does gill boundary layer carbonic anhydrase contribute to carbon dioxide excretion: a comparison between dogfish (Squalus acanthias) and rainbow trout (Oncorhynchus mykiss). J Exp Biol. 1999;202:749-56 pubmed
    ..3 mg kg-1) of the inhibitor benzolamide caused a significant reduction in the acid-base disequilibrium after 5 min (from -0.11+/-0.01 to -0.07+/-0...
  28. Maren T, Fine A, Swenson E, Rothman D. Renal acid-base physiology in marine teleost, the long-horned sculpin (Myoxocephalus octodecimspinosus). Am J Physiol. 1992;263:F49-55 pubmed
  29. Gottfried J, Chesler M. Endogenous H+ modulation of NMDA receptor-mediated EPSCs revealed by carbonic anhydrase inhibition in rat hippocampus. J Physiol. 1994;478 Pt 3:373-8 pubmed
    ..Here we amplify these pH shifts using benzolamide (a carbonic anhydrase inhibitor) and describe concomitant effects on EPSCs in whole-cell clamped CA1 neurones ..
  30. Maresca A, Scozzafava A, Vullo D, Supuran C. Dihalogenated sulfanilamides and benzolamides are effective inhibitors of the three ?-class carbonic anhydrases from Mycobacterium tuberculosis. J Enzyme Inhib Med Chem. 2013;28:384-7 pubmed publisher
    A series of halogenated sulfanilamides and halogenated benzolamide derivatives have been investigated as inhibitors of three ?-carbonic anhydrases (CAs, EC 4.2.1...
  31. Swenson E, Grønlund J, Ohlsson J, Hlastala M. In vivo quantitation of carbonic anhydrase and band 3 protein contributions to pulmonary gas exchange. J Appl Physiol (1985). 1993;74:838-48 pubmed
    ..ethoxzolamide (a lipophilic CA inhibitor with rapid membrane penetrance) to inhibit RBC and lung tissue CA, and benzolamide (an extremely hydrophilic CA inhibitor with virtually no penetrance into RBC cytoplasm) to inhibit only lung ..
  32. Shimoda L, Luke T, Sylvester J, Shih H, Jain A, Swenson E. Inhibition of hypoxia-induced calcium responses in pulmonary arterial smooth muscle by acetazolamide is independent of carbonic anhydrase inhibition. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1002-12 pubmed
    ..Using fluorescent microscopy, we tested the effect of AZ as well as two other potent CA inhibitors, benzolamide and ethoxzolamide, which exhibit low and high membrane permeability, respectively, on hypoxia-induced responses ..
  33. Vargas L, Pinilla O, Díaz R, Sepúlveda D, Swenson E, Perez N, et al. Carbonic anhydrase inhibitors reduce cardiac dysfunction after sustained coronary artery ligation in rats. Cardiovasc Pathol. 2016;25:468-477 pubmed publisher
    Two potent carbonic anhydrase (CA) inhibitors with widely differing membrane permeability, poorly diffusible benzolamide (BZ), and highly diffusible ethoxzolamide (ETZ) were assessed to determine whether they can reduce cardiac ..
  34. Mastrolorenzo A, Scozzafava A, Supuran C. Antifungal activity of Ag(I) and Zn(II) complexes of aminobenzolamide (5-sulfanilylamido-1,3,4-thiadiazole-2-sulfonamide) derivatives. J Enzyme Inhib. 2000;15:517-31 pubmed
    ..Probably the new complexes act as inhibitors of phosphomannose isomerase, a key enzyme in the biosynthesis of yeast cell walls. ..
  35. Vogh B. The relation of choroid plexus carbonic anhydrase activity to cerebrospinal fluid formation: study of three inhibitors in cat with extrapolation to man. J Pharmacol Exp Ther. 1980;213:321-31 pubmed
    ..This study relates the inhibition of CSF flow in cats after 1 to 30 mg/kg of methazolamide, acetazolamide or benzolamide (inhibitors of differing pharmacokinetic properties) to plasma and choroid plexus levels of these drugs...
  36. Voipio J, Paalasmaa P, Taira T, Kaila K. Pharmacological characterization of extracellular pH transients evoked by selective synaptic and exogenous activation of AMPA, NMDA, and GABAA receptors in the rat hippocampal slice. J Neurophysiol. 1995;74:633-42 pubmed
    ..Inhibition of CAo was achieved with the use of the poorly permeant carbonic anhydrase inhibitor, benzolamide (10 microM; applied in the bath solution) or the impermeant macromolecular inhibitor, prontosil-dextran 5000 (..
  37. Wolfensberger T, Chiang R, Takeuchi A, Marmor M. Inhibition of membrane-bound carbonic anhydrase enhances subretinal fluid absorption and retinal adhesiveness. Graefes Arch Clin Exp Ophthalmol. 2000;238:76-80 pubmed
    ..This study investigates how benzolamide, a carbonic anhydrase inhibitor which does not readily penetrate cell membranes, modulates retinal pigment ..
  38. Goldfarb D, Sly W, Waheed A, Charney A. Acid-base effects on electrolyte transport in CA II-deficient mouse colon. Am J Physiol Gastrointest Liver Physiol. 2000;278:G409-15 pubmed
    ..Membrane-permeant methazolamide, but not impermeant benzolamide, at 0.1 mM prevented the effects of pH...
  39. Wolfensberger T, Dmitriev A, Govardovskii V. Inhibition of membrane-bound carbonic anhydrase decreases subretinal pH and volume. Doc Ophthalmol. 1999;97:261-71 pubmed
    ..This study investigates whether benzolamide, a hydrophilic CA inhibitor that does not readily penetrate cell membranes, is sufficient to modulate ..
  40. Taira T, Smirnov S, Voipio J, Kaila K. Intrinsic proton modulation of excitatory transmission in rat hippocampal slices. Neuroreport. 1993;4:93-6 pubmed
    ..upon inhibition of fast extracellular H+ buffering by a poorly-permeant carbonic anhydrase inhibitor, benzolamide (10 microM)...
  41. Akiba Y, Ghayouri S, Takeuchi T, Mizumori M, Guth P, Engel E, et al. Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum. Gastroenterology. 2006;131:142-52 pubmed
    ..The permeant carbonic anhydrase (CA) inhibitor methazolamide, relatively impermeant CA inhibitor benzolamide, vanilloid receptor antagonist capsazepine, or sodium-hydrogen exchanger 1 (NHE-1) inhibitor dimethyl amiloride ..
  42. Swenson E, Robertson H, Hlastala M. Effects of carbonic anhydrase inhibition on ventilation-perfusion matching in the dog lung. J Clin Invest. 1993;92:702-9 pubmed
    ..as a control for duration of anesthesia, (b) 4% CO2 inhalation to mimic systemic CO2 retention, (c) 1 mg/kg benzolamide (a selective renal CA inhibitor) or 0...
  43. Supuran C, Scozzafava A. Benzolamide is not a membrane-impermeant carbonic anhydrase inhibitor. J Enzyme Inhib Med Chem. 2004;19:269-73 pubmed
    b>Benzolamide, an orphan drug belonging to the pharmacological class of sulfonamide carbonic anhydrase (CA, EC 4.2.1...
  44. Vullo D, Bhatt A, Mahon B, McKenna R, Supuran C. Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA. Bioorg Med Chem Lett. 2016;26:401-405 pubmed publisher
    ..including acetazolamide, methazolamide, ethoxzolamide, dichlorophenamide, dorzolamide, brinzolamide, benzolamide and benzenesulfonamides incorporating 4-hydroxyalkyl moieties...
  45. Leniger T, Wiemann M, Bingmann D, Widman G, Hufnagel A, Bonnet U. Carbonic anhydrase inhibitor sulthiame reduces intracellular pH and epileptiform activity of hippocampal CA3 neurons. Epilepsia. 2002;43:469-74 pubmed
    ..activity (induced by 50 microM 4-aminopyridine) were compared with those of the CA inhibitors acetazolamide and benzolamide. In the majority of neurons, sulthiame (1.0-1.5 mM; n = 8) as well as the membrane permeant acetazolamide (0...
  46. Gilmour K, Perry S, Bernier N, Henry R, Wood C. Extracellular carbonic anhydrase in the dogfish, Squalus acanthias: a role in CO2 excretion. Physiol Biochem Zool. 2001;74:477-92 pubmed
    ..Inhibition constants (K(i)) against acetazolamide and benzolamide were 4.2 and 3.5 nmol L(-1), respectively. Use of a low dose (1...
  47. Kreitzer M, Swygart D, Osborn M, Skinner B, Heer C, Kaufman R, et al. Extracellular H+ fluxes from tiger salamander Müller (glial) cells measured using self-referencing H+-selective microelectrodes. J Neurophysiol. 2017;118:3132-3143 pubmed publisher
    ..The carbonic anhydrase antagonist benzolamide potentiated the potassium-induced extracellular acidification, while 300 ?M DIDS, 300 ?M SITS, and 30 ?M S0859 ..
  48. Akiba Y, Mizumori M, Kuo M, Ham M, Guth P, Engel E, et al. CO2 chemosensing in rat oesophagus. Gut. 2008;57:1654-64 pubmed publisher
    ..the cell-permeant carbonic anhydrase (CA) inhibitor methazolamide (MTZ, 1 mM), the cell-impermeant CA inhibitor benzolamide (BNZ, 0.1 mM), the transient receptor potential vanilloid 1 (TRPV1) antagonist capsazepine (CPZ, 0...
  49. Perry S, Gilmour K, Swenson E, Vulesevic B, Chew S, Ip Y. An investigation of the role of carbonic anhydrase in aquatic and aerial gas transfer in the African lungfish Protopterus dolloi. J Exp Biol. 2005;208:3805-15 pubmed
    ..Intravascular injection of low levels (1.2 mg kg(-1)) of the slowly permanent CA inhibitor, benzolamide, was without effect on red blood cell CA activity after 30 min, thus confirming its suitability as a short-term ..
  50. Tsuruoka S, Schwartz G. HCO3- absorption in rabbit outer medullary collecting duct: role of luminal carbonic anhydrase. Am J Physiol. 1998;274:F139-47 pubmed
    ..transport in perfused OMCDi segments and examined the effect on transport of two extracellular CA inhibitors, benzolamide and F-3500, aminobenzolamide coupled to a nontoxic polymer, polyoxyethylene bis(acetic acid) [synthesized and ..
  51. Henry R, Smatresk N, Cameron J. The distribution of branchial carbonic anhydrase and the effects of gill and erythrocyte carbonic anhydrase inhibition in the channel catfish Ictalurus punctatus. J Exp Biol. 1988;134:201-18 pubmed
    ..Intact animals were injected with the CA inhibitors acetazolamide and benzolamide. Slow, intra-arterial injection of both inhibitors elicited transient side effects of apnoea, bradycardia and ..
  52. Planelles G, Discala F, Anagnostopoulos T. Luminal pH in the amphibian distal tubule: effects of carbonic anhydrase and carbonic anhydrase inhibitors. Am J Physiol. 1992;263:R1254-9 pubmed
    ..During intravenous infusion with benzolamide DTi steady-state pHlu falls, suggesting that this maneuver inhibits a functional luminal CA, in contrast to the ..
  53. Chen J, Chesler M. Modulation of extracellular pH by glutamate and GABA in rat hippocampal slices. J Neurophysiol. 1992;67:29-36 pubmed
    ..5. Superfusion of 10(-5)-10(-3) M acetazolamide acidified the baseline by 0.05-0.10 pH units and amplified the Schaffer collateral- and glutamate-evoked alkaline shifts.(ABSTRACT TRUNCATED AT 250 WORDS) ..