Summary: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48)

Top Publications

  1. Dai J, Wang W, Liang Y, Li H, Guan X, Zhu Y. A novel molluscicidal formulation of niclosamide. Parasitol Res. 2008;103:405-12 pubmed publisher
    ..Currently, only one chemical molluscicide, niclosamide, which is used as 50% wettable powder of niclosamide ethanolamine salt (WPN), is commercially available for ..
  2. Dai J, Zhou X, Liang Y, Zhang Y, Jiang Y, Xi W, et al. [Sensitivity of Oncomelania snail to niclosamide in China]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2002;20:101-5 pubmed
    To understand the variation in response of Oncomelania hupensis to niclosamide.
  3. Imperi F, Massai F, Ramachandran Pillai C, Longo F, Zennaro E, Rampioni G, et al. New life for an old drug: the anthelmintic drug niclosamide inhibits Pseudomonas aeruginosa quorum sensing. Antimicrob Agents Chemother. 2013;57:996-1005 pubmed publisher
    ..We found that the anthelmintic drug niclosamide strongly inhibits the P. aeruginosa QS response and production of acyl-homoserine lactone QS signal molecules...
  4. Pan J, Ding K, Wang C. Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells. Chin J Cancer. 2012;31:178-84 pubmed publisher
    b>Niclosamide, an oral antihelminthic drug, has been used to treat tapeworm infection for about 50 years. Niclosamide is also used as a molluscicide for water treatment in schistosomiasis control programs...
  5. Park S, Shin J, Kang H, Hwang J, Cho D. Niclosamide induces mitochondria fragmentation and promotes both apoptotic and autophagic cell death. BMB Rep. 2011;44:517-22 pubmed
    ..To identify specific regulators to mitochondria dynamics, we screened a chemical library and identified niclosamide as a potent inducer of mitochondria fission...
  6. Liu C, Lou W, Zhu Y, Nadiminty N, Schwartz C, Evans C, et al. Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration-resistant prostate cancer. Clin Cancer Res. 2014;20:3198-3210 pubmed publisher
    ..This study was designed to identify inhibitors of AR variants and test its ability to overcome resistance to enzalutamide...
  7. Dai J, Coles G, Wang W, Liang Y. Toxicity of a novel suspension concentrate of niclosamide against Biomphalaria glabrata. Trans R Soc Trop Med Hyg. 2010;104:304-6 pubmed publisher
    As a new suspension concentrate of niclosamide (SCN) was more effective in controlling Oncomelania snails than a wettable powder of the same drug, it was tested against Biomphalaria glabrata...
  8. Navab M, Ruchala P, Waring A, Lehrer R, Hama S, Hough G, et al. A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids. J Lipid Res. 2009;50:1538-47 pubmed publisher
    ..Orally administering niclosamide (a chlorinated salicylanilide used as a molluscicide, antihelminthic, and lampricide) in temporal proximity to ..
  9. Merschjohann K, Steverding D. In vitro trypanocidal activity of the anti-helminthic drug niclosamide. Exp Parasitol. 2008;118:637-40 pubmed publisher
    ..In this study, the anti-helminthic drug niclosamide was tested for its trypanocidal activity in vitro using culture-adapted bloodstream forms of Trypanosoma brucei ..

More Information


  1. Lowe D, Xi J, Meng X, Wu Z, Qiu D, Spear R. Transport of Schistosoma japonicum cercariae and the feasibility of niclosamide for cercariae control. Parasitol Int. 2005;54:83-9 pubmed
    ..infective in village irrigation ditches and to determine the feasibility of interrupting this transport using niclosamide, the molluscicide commonly used for snail control in this environment...
  2. Graebing P, Chib J, Hubert T, Gingerich W. Aqueous photolysis of niclosamide. J Agric Food Chem. 2004;52:870-8 pubmed
    The photodegradation of [(14)C]niclosamide was studied in sterile, pH 5, 7, and 9 buffered aqueous solutions under artificial sunlight at 25.0 +/- 1.0 degrees C. Photolysis in pH 5 buffer is 4.3 times faster than in pH 9 buffer and 1...
  3. Li R, Hu Z, Sun S, Chen Z, Owonikoko T, Sica G, et al. Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer. Mol Cancer Ther. 2013;12:2200-12 pubmed publisher
    ..Both blockage of Tyr705 phosphorylation of STAT3 by niclosamide and depletion of STAT3 by RNA interference in HCC827/ER cells reverse erlotinib resistance...
  4. Li R, You S, Hu Z, Chen Z, Sica G, Khuri F, et al. Inhibition of STAT3 by niclosamide synergizes with erlotinib against head and neck cancer. PLoS ONE. 2013;8:e74670 pubmed publisher
    ..Pharmacological inhibition of STAT3 by niclosamide not only blocked erlotinib-stimulated STAT3 phosphorylation but also synergistically repressed head and neck ..
  5. Lu W, Lin C, Roberts M, Waud W, Piazza G, Li Y. Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/?-catenin pathway. PLoS ONE. 2011;6:e29290 pubmed publisher
    ..Recently, the antihelminthic drug, niclosamide was found to inhibit Wnt/?-catenin signaling, although the mechanism was not well defined...
  6. Wang Y, Chao T, Chang C, Yo Y, Yu M, Lai H. Drug screening identifies niclosamide as an inhibitor of breast cancer stem-like cells. PLoS ONE. 2013;8:e74538 pubmed publisher
    ..A clinically approved drug, niclosamide, was identified from the LOPAC chemical library of 1,258 compounds...
  7. Balgi A, Fonseca B, Donohue E, Tsang T, Lajoie P, Proud C, et al. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS ONE. 2009;4:e7124 pubmed publisher
    ..Addressing the therapeutic potential of modulating mTORC1 signaling and autophagy in human disease requires active chemicals with pharmacologically desirable properties...
  8. Graebing P, Chib J, Hubert T, Gingerich W. Metabolism of niclosamide in sediment and water systems. J Agric Food Chem. 2004;52:5924-32 pubmed
    A series of experiments analyzed the kinetics and mechanisms of [(14)C]niclosamide degradation. The aerobic aquatic metabolism of [(14)C]niclosamide was studied in nonsterile river water/sediment mixtures...
  9. Chen M, Wang J, Lu J, Bond M, Ren X, Lyerly H, et al. The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Biochemistry. 2009;48:10267-74 pubmed publisher
    ..We now report that the anti-helminthic niclosamide, a drug used for the treatment of tapeworm, promotes Frizzled1 endocytosis, downregulates Dishevelled-2 protein,..
  10. Wu Z, Wang T, Zhang X, Zhong B, Xu L, Gao G, et al. [Snail control by using soil pasting mixed with niclosamide]. Zhonghua Yu Fang Yi Xue Za Zhi. 2008;42:569-73 pubmed
    To evaluate the effect of snail control through soil pasting mixed with niclosamide.
  11. Tchounwou P, Englande A, Malek E, Anderson A, Abdelghani A. The effects of bayluscide and malathion on the survival of Schistosoma mansoni miracidia. J Environ Sci Health B. 1991;26:69-82 pubmed
    ..Such uses could help reducing the risk of schistosomiasis transmission in these particular locations...
  12. Wang A, Ku H, Liang Y, Chen Y, Hwu Y, Yeh T. The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells. J Cell Biochem. 2009;106:682-92 pubmed publisher
    ..luciferase activity of CBF1-dependent reporter gene was activated by baicalin and baicalein but suppressed by niclosamide in both dose- and time-dependent manners...
  13. Giovanelli A, Silva C, Medeiros L, Vasconcellos M. The molluscicidal activity of niclosamide (Bayluscide WP70(R)) on Melanoides tuberculata (Thiaridae), a snail associated with habitats of Biomphalaria glabrata (Planorbidae). Mem Inst Oswaldo Cruz. 2002;97:743-5 pubmed
    The aim of this study was to determine the toxicity of niclosamide (Bayluscide (R)) on Melanoides tuberculata and Biomphalaria glabrata under laboratory conditions...
  14. Arend R, Londoño Joshi A, Samant R, Li Y, Conner M, Hidalgo B, et al. Inhibition of Wnt/?-catenin pathway by niclosamide: a therapeutic target for ovarian cancer. Gynecol Oncol. 2014;134:112-20 pubmed publisher
    ..The Wnt/?-catenin pathway is known to regulate cellular proliferation and plays a role in chemoresistance. Niclosamide, an FDA approved salicyclamide derivative used for the treatment of tapeworm infections, targets the Wnt/?-..
  15. Osada T, Chen M, Yang X, Spasojevic I, VanDeusen J, Hsu D, et al. Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations. Cancer Res. 2011;71:4172-82 pubmed publisher
    ..The antihelminth compound niclosamide downregulates components of the Wnt pathway, specifically Dishevelled-2 (Dvl2) expression, resulting in ..
  16. Fonseca B, Diering G, Bidinosti M, Dalal K, Alain T, Balgi A, et al. Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling. J Biol Chem. 2012;287:17530-45 pubmed publisher
    ..We have recently identified niclosamide (a Food and Drug Administration-approved antihelminthic drug) as an inhibitor of mTORC1 signaling...
  17. Yo Y, Lin Y, Wang Y, Balch C, Huang R, Chan M, et al. Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012;11:1703-12 pubmed publisher
    ..Of 61 potential compounds preliminarily identified, more stringent assessments showed that the antihelmintic niclosamide selectively targets OTICs in vitro and in vivo...
  18. Devarakonda B, Hill R, Liebenberg W, Brits M, de Villiers M. Comparison of the aqueous solubilization of practically insoluble niclosamide by polyamidoamine (PAMAM) dendrimers and cyclodextrins. Int J Pharm. 2005;304:193-209 pubmed
    This study is the first report of the solubilization of niclosamide by cyclodextrin complexation or the interaction between the drug and polyamidoamine (PAMAM) dendrimers...
  19. Abreu F, Goulart M, Brett A. Detection of the damage caused to DNA by niclosamide using an electrochemical DNA-biosensor. Biosens Bioelectron. 2002;17:913-9 pubmed
    b>Niclosamide is the only commercially available molluscicide recommended by the WHO for large-scale use in schistosomiasis control programs...
  20. Gies E, Wilde I, Winget J, Brack M, Rotblat B, Novoa C, et al. Niclosamide prevents the formation of large ubiquitin-containing aggregates caused by proteasome inhibition. PLoS ONE. 2010;5:e14410 pubmed publisher
    ..Both systems are interconnected and, in some instances, autophagy can redirect proteasome substrates to the lysosomes...
  21. Gallella S, Gunawardena G, Karunaweera N. Bertiella studeri infection: resistance to niclosamide. Ceylon Med J. 2004;49:65 pubmed
  22. Jin Y, Lu Z, Ding K, Li J, Du X, Chen C, et al. Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer Res. 2010;70:2516-27 pubmed publisher
    ..In this report, we initially discovered that the potent antineoplastic effect of niclosamide, a Food and Drug Administration-approved antihelminthic agent, was through inhibition of the NF-kappaB pathway ..
  23. Sack U, Walther W, Scudiero D, Selby M, Kobelt D, Lemm M, et al. Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancer. J Natl Cancer Inst. 2011;103:1018-36 pubmed publisher
    ..Metastasis formation in colon cancer severely reduces the survival rate in patients. S100A4, a calcium-binding protein, is implicated in promoting metastasis formation in colon cancer...
  24. Wu C, Jan J, Chen C, Hsieh H, Hwang D, Liu H, et al. Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide. Antimicrob Agents Chemother. 2004;48:2693-6 pubmed
    Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral ..
  25. Zhang X, Yap Y. Old drugs as lead compounds for a new disease? Binding analysis of SARS coronavirus main proteinase with HIV, psychotic and parasite drugs. Bioorg Med Chem. 2004;12:2517-21 pubmed
    ..its binding pockets and affinities with existing HIV, psychotic and parasite drugs (lopinavir, ritonavir, niclosamide and promazine), which show signs of inhibiting the replication of SARS-CoV...
  26. Wu H, Zhang S, Bian H, Li X, Wang L, Pu Y, et al. Bevacizumab Regulates Cancer Cell Migration by Activation of STAT3. Asian Pac J Cancer Prev. 2015;16:6501-6 pubmed
    ..The signal transducer and activator of transcription (STAT) 3 inhibitors niclosamide and S3I-201 inhibited the STAT3 signal pathway, which is activated by bevacizumab...
  27. Lu D, Ma Z, Zhang T, Zhang X, Wu B. Metabolism of the anthelmintic drug niclosamide by cytochrome P450 enzymes and UDP-glucuronosyltransferases: metabolite elucidation and main contributions from CYP1A2 and UGT1A1. Xenobiotica. 2016;46:1-13 pubmed publisher
    1. Niclosamide is an old anthelmintic drug that shows potential in fighting against cancers...
  28. Mosta Fa B, el Deeb F, Ismail N, el Said K. Impact of certain plants and synthetic molluscicides on some fresh water snails and fish. J Egypt Soc Parasitol. 2005;35:989-1007 pubmed
    ..In contrast, the LC50 of Niclosamide (0.11 ppm) and Copper sulphate (CuSO4) (0.42 ppm) against B...
  29. Sitcharungsil R, Watthanakulpanich D. TAENIA SAGINATA INFECTION IN A 14-MONTH-OLD TODDLER. Southeast Asian J Trop Med Public Health. 2016;47:394-8 pubmed
    ..Single doses of praziquantel and niclosamide were administered. To the best of our knowledge, this is the youngest described patient with T...
  30. Mook R, Ren X, Wang J, Piao H, Barak L, Kim Lyerly H, et al. Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis. Bioorg Med Chem. 2017;25:1804-1816 pubmed publisher
    ..We reported previously that the anthelmintic drug Niclosamide inhibits Wnt/β-catenin signaling and suppresses colon cancer cell growth in vitro and in vivo...
  31. Khallaayoune K, Madsen H, Laamrani H. Evaluation of three methods to control Bulinus truncatus, the intermediate host of Schistosoma haematobium in an irrigation scheme, Tessaout-Amont, Morocco. Acta Trop. 1998;69:51-63 pubmed
    ..Molluscicide (niclosamide) application resulted in a pronounced reduction in the snail population density, but snails started to ..
  32. Jin B, Wang C, Shen Y, Pan J. Anthelmintic niclosamide suppresses transcription of BCR-ABL fusion oncogene via disabling Sp1 and induces apoptosis in imatinib-resistant CML cells harboring T315I mutant. Cell Death Dis. 2018;9:68 pubmed publisher
    ..Treatment of WT- and T315I-BCR-ABL-expressing CML cells by niclosamide diminished such an enrichment of Sp1, and decreased WT- and T315I-BCR-ABL transcription and its downstream ..
  33. El Shazly A, Morsy T, Dawoud H. Human Monieziasis expansa: the first Egyptian parastic zoonosis. J Egypt Soc Parasitol. 2004;34:515-8 pubmed
    ..Diagnosis was based on recovery of the characteristic eggs from the stool of a fifteen-years-old shepherd. A single dose of Niclosamide one gram proved effective.
  34. Zhu D, Xie F, Bao Z, Zhu D, Ni C. [Climbing-upward inhibition of Oncomelania hupensis by niclosamide combination]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2001;19:348-50 pubmed
    ..Experiments on molluscicidal and snail-climbing inhibition effect of the combination of niclosamide and shachongding [(dimethylamine) trithacyclohexane hydrochloride] were conducted by immersion and spraying in ..
  35. Chen B, Wei W, Ma L, Yang B, Gill R, Chua M, et al. Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling. Gastroenterology. 2017;152:2022-2036 pubmed publisher
    ..We evaluated the anti-tumor activity of niclosamide and its ethanolamine salt (NEN) in HCC cell lines (HepG2, Huh7, Hep3B, Hep40, and PLC/PRF/5), primary human ..
  36. Li X, Yang Z, Han Z, Wen Y, Ma Z, Wang Y. Niclosamide acts as a new inhibitor of vasculogenic mimicry in oral cancer through upregulation of miR-124 and downregulation of STAT3. Oncol Rep. 2018;39:827-833 pubmed publisher
    ..Up to this point, there is no effective drug reported for inhibiting VM formation. Niclosamide is an oral anti-helminthic drug used to treat human tapeworms...
  37. Arkhipov I, Sadov K, Limova Y, Sadova A, Varlamova A, Khalikov S, et al. The efficacy of the supramolecular complexes of niclosamide obtained by mechanochemical technology and targeted delivery against cestode infection of animals. Vet Parasitol. 2017;246:25-29 pubmed publisher
    b>Niclosamide is an anthelmintic that is widely used to treat cestode infection of animals...
  38. de Villiers M, Mahlatji M, van Tonder E, Malan S, Lötter A, Liebenberg W. Comparison of the physical and chemical stability of niclosamide crystal forms in aqueous versus nonaqueous suspensions. Drug Dev Ind Pharm. 2004;30:581-92 pubmed
    In an effort to produce physically stable and pharmaceutically acceptable suspensions of niclosamide, this study reports the differences in physical and chemical stability of aqueous vs...
  39. Ketola K, Hilvo M, Hyötyläinen T, Vuoristo A, Ruskeepää A, Oresic M, et al. Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress. Br J Cancer. 2012;106:99-106 pubmed publisher
  40. Liu J, Chen X, Ward T, Pegram M, Shen K. Combined niclosamide with cisplatin inhibits epithelial-mesenchymal transition and tumor growth in cisplatin-resistant triple-negative breast cancer. Tumour Biol. 2016;37:9825-35 pubmed publisher
    ..Recent studies suggested that niclosamide, an anti-helminthic drug, has potential therapeutic activities against breast cancer stem cells, which prompts ..
  41. Xie Y, Yao Y. Octenylsuccinate hydroxypropyl phytoglycogen enhances the solubility and in-vitro antitumor efficacy of niclosamide. Int J Pharm. 2018;535:157-163 pubmed publisher
    b>Niclosamide is a promising antitumor agent, but its low aqueous solubility places limit on its antitumor efficacy...
  42. Yin L, Gao Y, Zhang X, Wang J, Ding D, Zhang Y, et al. Niclosamide sensitizes triple-negative breast cancer cells to ionizing radiation in association with the inhibition of Wnt/?-catenin signaling. Oncotarget. 2016;7:42126-42138 pubmed publisher
    ..b>Niclosamide, a potent inhibitor of Wnt/?-catenin signaling, not only inhibited constitutive Wnt/?-catenin signaling, but ..
  43. Torres N, Abercrombie J, Srinivasan A, Lopez Ribot J, Ramasubramanian A, Leung K. Screening a Commercial Library of Pharmacologically Active Small Molecules against Staphylococcus aureus Biofilms. Antimicrob Agents Chemother. 2016;60:5663-72 pubmed publisher
    ..aureus We found that three of these drugs, niclosamide, carmofur, and auranofin, possessed antimicrobial activity against preformed biofilms, making them attractive ..
  44. Bustos J, Rodriguez S, Jimenez J, Moyano L, Castillo Y, Ayvar V, et al. Detection of Taenia solium taeniasis coproantigen is an early indicator of treatment failure for taeniasis. Clin Vaccine Immunol. 2012;19:570-3 pubmed publisher
    ..solium taeniasis. We followed 69 tapeworm carriers who received niclosamide as standard treatment...
  45. Gillis K, Clor J, Khan A, Tyagarajan K. Multiplexed approaches correlating mitochondrial health to cell health using microcapillary cytometry. Methods. 2018;134-135:106-112 pubmed publisher
    ..Dose and time response studies with Niclosamide, an anti-helmintic drug and comparison of effects with Gambogic acid and celastrol demonstrated early and ..
  46. Tu Z, Jiang B, Xue J, Tao Y, Wei Y, Zhang H. [Plasma Metabolism and Protective Effect of Oral Administration of Niclosamide on Schistosoma japonicum Cercarial Invasion in Mice]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2015;33:101-4 pubmed
    To study the metabolism of niclosamide in plasma, and the protective effect of its oral administration on Schistosoma japonicum cercarial invasion in mice...
  47. Sahin I, Köz S, Atambay M, Kayabas U, Piskin T, Unal B. A Rare Cause of Diarrhea in a Kidney Transplant Recipient: Dipylidium caninum. Transplant Proc. 2015;47:2243-4 pubmed publisher
    ..The patient was successfully treated with niclosamide. D. caninum should be considered as an agent of diarrhea in transplant patients.
  48. Rolfe P, Boray J. Chemotherapy of paramphistomosis in cattle. Aust Vet J. 1987;64:328-32 pubmed
    ..b>Niclosamide at 160 mg/kg given as single or 2 doses 3 days apart was 91.1% and 92...
  49. Hassan A, Shoukary N, Ismail N. Efficacy of temperature, and two commonly used molluscicides and fertilizers on Fasciola gigantica eggs. J Egypt Soc Parasitol. 2008;38:621-34 pubmed
    This study evaluated the effect of temperature, molluscicides (Copper sulphate and Niclosamide), fertilizers (Superphosphate and Ammonium sulphate) on the hatchability of Fasciola gigantica eggs...
  50. Schutte C, Evans A, Pammenter M, Cooppan R, Pretorius S, Joubert P, et al. Epidemiology and control of schistosomiasis mansoni in communities living on the Cuando River floodplain of East Caprivi, Namibia. Ann Trop Med Parasitol. 1995;89:631-44 pubmed
    ..6-monthly blanket treatments with praziquantel) combined with focal mollusciciding (monthly application of niclosamide) was used in a project in the area to control the disease...
  51. Marangi M, Zechini B, Fileti A, Quaranta G, Aceti A. Hymenolepis diminuta infection in a child living in the urban area of Rome, Italy. J Clin Microbiol. 2003;41:3994-5 pubmed
    ..Praziquantel is the drug of choice for the treatment of H. diminuta infection. However, considering the patient's neurological disease, we decided to use not praziquantel but niclosamide, which proved equally effective.
  52. Hubert T, Bernardy J, Vue C, Dawson V, Boogaard M, Schreier T, et al. Residues of the lampricides 3-trifluoromethyl-4-nitrophenol and niclosamide in muscle tissue of rainbow trout. J Agric Food Chem. 2005;53:5342-6 pubmed
    ..1 mg/L) or niclosamide (0.055 mg/L) in an aerated static water bath for 24 h. Fish were sacrificed immediately after exposure...
  53. Hassan G, Hegazy G, Safwat H. Synthesis of furo-salicylanilides and their heterocyclic derivatives with anticipated molluscicidal activity. Arch Pharm (Weinheim). 2006;339:448-55 pubmed
    ..Five of the tested compounds showed no activity, while eighteen compounds showed strong to moderate activity using bayluscide as a reference...
  54. Yang G, Sun L, Hong Q, Zhu H, Yang K, Gao Q, et al. Optimizing molluscicide treatment strategies in different control stages of schistosomiasis in the People's Republic of China. Parasit Vectors. 2012;5:260 pubmed publisher
  55. Neghina R, Neghina A, Marincu I, Iacobiciu I. Human taeniasis in western Romania and its relationship to multicultural food habits and influences. Foodborne Pathog Dis. 2010;7:489-92 pubmed publisher
    ..This study aimed to overview the epidemiological, clinical, and therapeutic characteristics of taeniasis cases diagnosed in Timis County, part of Banat region, during a 37-year period (1971-2007)...
  56. Patamia I, Cappello E, Castellano Chiodo D, Greco F, Nigro L, Cacopardo B. A human case of Hymenolepis diminuta in a child from eastern Sicily. Korean J Parasitol. 2010;48:167-9 pubmed publisher
    ..The patient was treated with a 7-day cycle of oral niclosamide, which proved to be safe and effective...
  57. Peng G, Hu Z, Bao Z, Zhou Y, Xiong Z, Chen H, et al. [Effect of niclosamide spreading oil on killing schistosome cercariae]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2012;24:368, 370 pubmed
    Dechlorinated water (100 ml, 30 degrees C) was put into a plate (diameter 15 cm), and 1% niclosamide spreading oil 5 microl was added, then a ring of Schistosoma japonicum cercariae were picked up to the plate...
  58. Inceboz T, Yalçin G, Aksoy U. [Case report: taeniasis, is it a cause of psychiatric and neural symptoms?]. Turkiye Parazitol Derg. 2006;30:187-9 pubmed
    ..She was given treatment with niclosamide and purgative treatment...
  59. Xing Y, Dai Y, Li Y, Jia Y, Li H, Qu G, et al. [Distribution of niclosamide spreading oil on water surface and its efficacy against cercariae of Schistosoma japonicum]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2012;24:410-4 pubmed
    To investigate the distribution and spreading speed of niclosamide spreading oil, as well as its effect against cercariae of Schistosoma japonicum.
  60. van Tonder E, Mahlatji M, Malan S, Liebenberg W, Caira M, Song M, et al. Preparation and physicochemical characterization of 5 niclosamide solvates and 1 hemisolvate. AAPS PharmSciTech. 2004;5:E12 pubmed
    The purpose of the study was to characterize the physicochemical, structural, and spectral properties of the 1:1 niclosamide and methanol, diethyl ether, dimethyl sulfoxide, N,N' dimethylformamide, and tetrahydrofuran solvates and the 2:..
  61. Li B, Li W, Feng X, Dong Y, Wu M, Shao Z, et al. [Molluscicidal effect of suspension concentrate of metaldehyde and niclosamide in fields of mountainous areas in Yunnan Province]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2012;24:564-6 pubmed
    To evaluate the molluscicidal effect of 26% suspension concentrate of metaldehyde and niclosamide (MNSC) in the fields of mountainous areas in Yunnan Province.
  62. Kim S, Song J, Jeong J, Seo H. Niclosamide inhibits leaf blight caused by Xanthomonas oryzae in rice. Sci Rep. 2016;6:21209 pubmed publisher
    ..Here, we show that Xoo-induced rice leaf blight is effectively controlled by niclosamide, an oral antihelminthic drug and molluscicide, which also functions as an anti-tumor agent...
  63. Achir I, Zait H, Hamrioui B. [Human infection due to Bertiella sp (cestode: Anoplocephalidae) in a man originating from Yemen in Algeria]. Bull Soc Pathol Exot. 2008;101:107-8 pubmed
    ..Human infection is asymptomatic or can induce minor non specific digestive disturbances and the niclosamide is effective in one single dose...
  64. Xing Y, Li Y, Li H, Qu G, Wang W, Wei J, et al. [Study on preservation of niclosamide in water samples]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2011;23:133-7 pubmed
    To investigate the preservation condition of niclosamide in water samples and establish a high performance liquid chromatography (HPLC) method by solid-phase extraction (SPE) which is used for determination and preservation of ..
  65. Chen W, Chen M, Barak L. Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach. Am J Physiol Gastrointest Liver Physiol. 2010;299:G293-300 pubmed publisher
    ..In particular, we summarize the results of a screen of over 1,200 drug and druglike compounds we recently completed in which niclosamide was identified as a Wnt pathway antagonist.
  66. Huang N, Li B, Li W, Feng X, Xiong M, Li L, et al. [Effect of a novel plant molluscicide "Luo-wei" against Oncomelania hupensis in plateau mountain areas]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2013;25:590-3 pubmed
    ..To evaluate the effect of a novel plant molluscicide, 4%"Luo-wei" (Tea-seed distilled saponins, TDS) against Oncomelania hupensis snails in plateau mountain areas in Yunnan Province...
  67. Liu J, Chen X, Ward T, Mao Y, Bockhorn J, Liu X, et al. Niclosamide inhibits epithelial-mesenchymal transition and tumor growth in lapatinib-resistant human epidermal growth factor receptor 2-positive breast cancer. Int J Biochem Cell Biol. 2016;71:12-23 pubmed publisher
    ..b>Niclosamide, an anti-helminthic agent, has recently been shown to exhibit cytotoxicity to tumor cells with stem-like ..
  68. Wu Y, Gong D, Peng X, Xie H, Han B. [Determination of niclosamide ethanolamine residue in rice and paddy field by high performance liquid chromatography]. Se Pu. 2011;29:1098-102 pubmed
    A high performance liquid chromatographic (HPLC) method was established for the analysis of niclosamide ethanolamine residue in rice and paddy field...
  69. Oliveira Filho E, Geraldino B, Coelho D, De Carvalho R, Paumgartten F. Comparative toxicity of Euphorbia milii latex and synthetic molluscicides to Biomphalaria glabrata embryos. Chemosphere. 2010;81:218-27 pubmed publisher
    ..30 microg L(-1))>niclosamide (NCL; LC(50)=70 microg L(-1))>copper sulphate (CuSO(4); LC(50)=2190 microg L(-1)) > LAT (LC(50)=34030 ..
  70. Li Y, Xing Y, Li H, Qu G, Wang W, Wei J, et al. [Studies on standardization of methods for screening molluscicides in laboratory IV sensitivity of Oncomelania snails from different months to niclosamide]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2012;24:35-9 pubmed
    To understand the sensitivity of Oncomelania snails collected from different months to niclosamide, so as to provide the scientific evidence for the standardization of methods for molluscicide screening and efficacy evaluation in ..
  71. Yang W, de Villiers M. Effect of 4-sulphonato-calix[n]arenes and cyclodextrins on the solubilization of niclosamide, a poorly water soluble anthelmintic. AAPS J. 2005;7:E241-8 pubmed
    ..and combinations of these macromolecules on the aqueous solubility of a poorly water-soluble drug, niclosamide. Complexation between the macromolecules and niclosamide was confirmed by thermal analysis and phase solubility ..
  72. Wu Y, Ning A, Zhou X, Xu J, Li J, Zheng S, et al. [Molluscicidal effect and toxicity of META-Li on Oncomelania snails in the mountain area]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2009;27:285-7 pubmed
    The molluscicidal effect and toxicity of META-Li were evaluated and compared with niclosamide in Yushan county of Jiangxi Province in August 2008...
  73. Ostlind D, Mickle W, Smith S, Cifelli S, Ewanciw D. The Hymenolepis diminuta-golden hamster (Mesocricetus auratus) model for the evaluation of gastrointestinal anticestode activity. J Parasitol. 2004;90:898-9 pubmed
    ..The commercial anticestode compounds, praziquantel, bunamidine, and niclosamide were active against patent infections of Hymenolepis diminuta in golden hamsters (Mesocricetus auratus) when ..
  74. de Villiers M, Mahlatji M, Malan S, van Tonder E, Liebenberg W. Physical transformation of niclosamide solvates in pharmaceutical suspensions determined by DSC and TG analysis. Pharmazie. 2004;59:534-40 pubmed
    This study reports the preparation of four niclosamide solvates and the determination of the stability of the crystal forms in different suspension vehicles by DSC and TG analysis...
  75. Yan X, Yang M, Lou L. [Preliminary test of the effect of niclosamide-impregnated tissue for the prevention of Schistosoma japonicum infection]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2003;21:313 pubmed