carbenicillin

Summary

Summary: Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.

Top Publications

  1. Trouillet J, Vuagnat A, Combes A, Kassis N, Chastre J, Gibert C. Pseudomonas aeruginosa ventilator-associated pneumonia: comparison of episodes due to piperacillin-resistant versus piperacillin-susceptible organisms. Clin Infect Dis. 2002;34:1047-54 pubmed
    ..Restricted fluoroquinolone use is the sole independent risk factor for PRPA VAP that is open to medical intervention. ..
  2. Spoering A, Lewis K. Biofilms and planktonic cells of Pseudomonas aeruginosa have similar resistance to killing by antimicrobials. J Bacteriol. 2001;183:6746-51 pubmed
    ..b>Carbenicillin appeared to be completely ineffective against both stationary-phase cells and biofilms...
  3. Möker N, Dean C, Tao J. Pseudomonas aeruginosa increases formation of multidrug-tolerant persister cells in response to quorum-sensing signaling molecules. J Bacteriol. 2010;192:1946-55 pubmed publisher
    ..aeruginosa PAO1 or PA14 cultures but not in E. coli or S. aureus cultures. ..
  4. Jeon A, Obregón Henao A, Ackart D, Podell B, Belardinelli J, Jackson M, et al. 2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability. PLoS ONE. 2017;12:e0180925 pubmed publisher
    ..2-AI based small molecules potentiate the antimicrobial activity of ß-lactams by a mechanism that is distinct from specific inhibitors of ß-lactamase activity and therefore may have value as an adjunctive anti-TB treatment...
  5. Ketyi I. Resistance of Escherichia coli to some antibiotics and biocides in the intestinal biofilm of mice. Acta Microbiol Hung. 1991;38:33-41 pubmed
    ..This latency is a requirement for the stabilization of the monoflora. Formaldehyde and carbenicillin were equally effective in the planktonic and in the biofilm mode of growth...
  6. Ozaki K, Inoue A, Atobe H, Takahashi E, Konishi S. Serotypes and antimicrobial susceptibility of Pseudomonas aeruginosa strains isolated from diseased dogs. Nihon Juigaku Zasshi. 1990;52:233-9 pubmed
    ..As a result of antimicrobial susceptibility test, most canine strains were considered to be susceptible to 4 drugs, which were commonly used in both human and veterinary clinics, in contrast to human isolates. ..
  7. Roberts D, Cole P. N-acetylcysteine potentiates the anti-pseudomonas activity of carbenicillin in vitro. J Infect. 1981;3:353-9 pubmed
  8. Kucisec Tepes N. [Pseudomonas aeruginosa--a significant hospital pathogen and resistance to carbapenem]. Acta Med Croatica. 2004;58:313-21 pubmed
    ..The problems in laboratory practice are those of precise determination of the level and phenotype resistance of P. aeruginosa to carbapenems. ..
  9. Aplin R, Baldwin J, Schofield C, Waley S. Use of electrospray mass spectrometry to directly observe an acyl enzyme intermediate in beta-lactamase catalysis. FEBS Lett. 1990;277:212-4 pubmed
    ..In each case the molecular weight difference between the unreacted and the reacted beta-lactamase was consistent with the formation of an acyl enzyme. ..

More Information

Publications62

  1. Sanschagrin F, Bejaoui N, Levesque R. Structure of CARB-4 and AER-1 carbenicillin-hydrolyzing beta-lactamases. Antimicrob Agents Chemother. 1998;42:1966-72 pubmed
    ..The gene was characterized as a variant of group 2c carbenicillin-hydrolyzing beta-lactamases such as PSE-4, PSE-1, and CARB-3...
  2. Knothe H, Dette G. The in-vitro activity of ceftazidime against clinically important pathogens. J Antimicrob Chemother. 1981;8 Suppl B:33-41 pubmed
    ..Ceftazidime shows extremely high activity both against carbenicillin-sensitive and -resistant strains of Pseudomonas aeruginosa...
  3. Richards R, Xing J. Brodimoprim synergy against Enterococcus faecalis evaluated in vitro. J Antimicrob Chemother. 1996;38:27-37 pubmed
    Combinations of either brodimoprim or trimethoprim plus either carbenicillin, gentamicin, ciprofloxacin or rifampicin showed synergy at sub-inhibitory concentrations against both Enterococcus faecalis NCTC 5957 and 775...
  4. Azam M, Jan A, Kumar A, Siddiqui K, Mondal A, Haq Q. Study of pandrug and heavy metal resistance among E. coli from anthropogenically influenced Delhi stretch of river Yamuna. Braz J Microbiol. 2018;49:471-480 pubmed publisher
    ..against 21 antibiotics tested, with minimum inhibitory concentration values >256μg/mL for amoxicillin, carbenicillin, aztreonam, ceftazidime and cefotaxime...
  5. El Zahry M, Refaat I, Mohamed H, Rosenberg E, Lendl B. Utility of surface enhanced Raman spectroscopy (SERS) for elucidation and simultaneous determination of some penicillins and penicilloic acid using hydroxylamine silver nanoparticles. Talanta. 2015;144:710-6 pubmed publisher
    Elucidation and quantitative determination of some of commonly used penicillins (ampicillin, penicillin G and carbenicillin) in the presence of their main degradation product (penicilloic acid) were developed...
  6. Yang J, Bi H, Fan W, Zhang M, Wang H, Zhang P. Efficient embryogenic suspension culturing and rapid transformation of a range of elite genotypes of sweet potato (Ipomoea batatas [L.] Lam.). Plant Sci. 2011;181:701-11 pubmed publisher
  7. Abdelrahman Y, Rose L, Belland R. Developmental expression of non-coding RNAs in Chlamydia trachomatis during normal and persistent growth. Nucleic Acids Res. 2011;39:1843-54 pubmed publisher
    ..by northern blotting during (i) the normal developmental cycle, (ii) IFN-?-induced persistence and (iii) carbenicillin-induced persistence...
  8. Boonyalekha P, Meechai A, Tayapiwatana C, Kitidee K, Waraho Zhmayev D. Design and construction of a synthetic E. coli protease inhibitor detecting biomachine. Conf Proc IEEE Eng Med Biol Soc. 2017;2017:3580-3583 pubmed publisher
    ..The device was optimized by varying plating conditions such as incubation temperatures, induction levels, and Carbenicillin concentrations which was used as selection pressure...
  9. Batlle Almodóvar M, Dickinson F, Pérez Monrás M, Tamargo Martínez I, Similis A. [Bacterial meningitis and Pseudomonas aeruginosa: apropos of a case]. Rev Cubana Med Trop. 2005;57:230-2 pubmed
    ..The meningitis caused by Pseudomonas aeruginosa should be taken into consideration because of the severity of the clinical picture and the high mortality and increasing strain resistance. ..
  10. Verbist L, Verhaegen J. Ceftazidime: comparative in-vitro study. J Antimicrob Chemother. 1981;8 Suppl B:67-71 pubmed
    ..Ceftazidime retained its high activity against microorganisms with acquired as well as with natural resistance to other beta-lactam antibiotics. ..
  11. Gao Z, Jayaraj J, Muthukrishnan S, Claflin L, Liang G. Efficient genetic transformation of Sorghum using a visual screening marker. Genome. 2005;48:321-33 pubmed
    ..This report describes the successful use of GFP screening for efficient production of stably transformed sorghum plants without using antibiotics or herbicides as selection agents. ..
  12. Tang W, Luo X, Samuels V. Growth and differentiation of transgenic callus regulated by phytohormones and antibiotics in transformation of loblolly pine. Yi Chuan Xue Bao. 2002;29:166-74 pubmed
    ..Of the phytohormone (BA/IBA) and antibiotics administered, 500 mg/L carbenicillin combined with 2 mg/L BA and 0.5 mg/L IBA (BA/IBA = 4) resulted in a 54...
  13. Yamamoto T, Watanabe M, Matsumoto K, Sawai T. Tn2610, a transposon involved in the spread of the carbenicillin-hydrolyzing beta-lactamase gene. Mol Gen Genet. 1983;189:282-8 pubmed
    We have found a new transposon, Tn2610, on pCS200 in clinical isolates of Escherichia coli, which encodes the carbenicillin-hydrolyzing beta-lactamase gene in combination with the resistance determinants to streptomycin and sulfonamide...
  14. Paul G, Joly Guillou M, Bergogne Berezin E, Nevot P, Philippon A. Novel carbenicillin-hydrolyzing beta-lactamase (CARB-5) from Acinetobacter calcoaceticus var. anitratus. FEMS Microbiol Lett. 1989;50:45-50 pubmed
    ..This enzyme was periplasmic with a characteristic substrate profile of a carbenicillin-hydrolyzing enzyme...
  15. Cox C. Ofloxacin in the management of complicated urinary tract infections, including prostatitis. Am J Med. 1989;87:61S-68S pubmed
    ..Compared with carbenicillin and trimethoprim/sulfamethoxazole in separate studies of complicated urinary tract infection, ofloxacin ..
  16. Jia C, Chen B, Su Y. [Preliminary study on multi-resistant gene location of 20 strains of Pseudomonas aeruginosa]. Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1995;11:330-1 pubmed
    ..In 30% the bacteria remained resistant to antibiotics after plasmids were removed. Two explanations were postulated. (1) plasmids were not removed completely; (2) resistance gene was encoded by the chromosomes. ..
  17. Uchida H, Yamashita H, Anai T, Muranaka T, Ohyama K. Agrobacterium-mediated transformation of Euphorbia tirucalli callus. Biosci Biotechnol Biochem. 2010;74:851-3 pubmed
    ..with Agrobacterium, washed with distilled water, sterilized with distilled water containing 100 mg/l of carbenicillin, selected on solidified B5 medium containing 13 mg/l of G418 and 100 mg/l of carbenicillin, and then on ..
  18. Stead R, Hodson M, Batten J. Inhaled ceftazidime compared with gentamicin and carbenicillin in older patients with cystic fibrosis infected with Pseudomonas aeruginosa. Br J Dis Chest. 1987;81:272-9 pubmed
    ..cross-over study was undertaken to compare nebulized (1) ceftazidime with (2) a combination of gentamicin and carbenicillin, and (3) saline, each given for 4 months, in patients with cystic fibrosis infected with Pseudomonas ..
  19. Lu Y, Love N, Grady C. Microscopic methods for distinguishing among three cell types in TOL plasmid-carrying Pseudomonas putida cultures. FEMS Microbiol Lett. 1999;173:195-201 pubmed
    ..X0 cells can be quantified in a background of 3500 X+ or X- cells using carbenicillin agarose miniplates...
  20. Itoh T, Nakashima K, Tsuda Y, Yamada H. Stereoselective binding of carbenicillin epimers to human serum albumin. Chirality. 1996;8:201-6 pubmed
    Binding of carbenicillin (CBPC) epimers to human serum albumin (HSA) was found to be stereoselective. Epimer-epimer interaction was also observed in the binding to HSA...
  21. Barthelemy M, Peduzzi J, Rowlands D, Paul G, Moreau G, Labia R. Val-237 for Ala substitution in the TEM-2 beta-lactamase dramatically alters the catalytic efficiencies towards carbenicillin and ticarcillin. FEMS Microbiol Lett. 1994;117:333-9 pubmed
    The mutant 554 of TEM-2 beta-lactamase was selected for a decrease in the resistance to carbenicillin of an Escherichia coli K12 carrier...
  22. Mao W, Warren M, Black D, Satou T, Murata T, Nishino T, et al. On the mechanism of substrate specificity by resistance nodulation division (RND)-type multidrug resistance pumps: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition. Mol Microbiol. 2002;46:889-901 pubmed
    ..These mutations enabled the pump to extrude the normally non-transported beta-lactam antibiotic carbenicillin. All amino acid substitutions were mapped to the large periplasmic loops (LPLs) of the RND proper, MexD...
  23. Kalasinsky K, Kalasinsky V. Infrared and Raman microspectroscopy of foreign materials in tissue specimens. Spectrochim Acta A Mol Biomol Spectrosc. 2005;61:1707-13 pubmed
    ..in an implant case, polyethylene terephthalate (PET) and polyacrylonitrile (PAN) in a pilonidal cyst, and carbenicillin in a skin biopsy...
  24. Itoh T, Koyano S, Nakaura H, Tsuda Y, Yamada H. Lack of renal secretion of carbenicillin in rats: poor affinity to the organic anion transporter at renal brush border membrane. Biopharm Drug Dispos. 1998;19:251-8 pubmed
    The renal secretion of carbenicillin (CBPC) was studied in rats. The results obtained in the in vivo study indicated very poor renal secretion of CBPC in rats, which was entirely different from those observed in humans and rabbits...
  25. Soussy C, Le Van Thoi J, Duval J. [Sensitivity to clavulanic acid of Escherichia coli isolated at the Henri Mondor hospital in 1986 according to phenotypes of beta-lactam antibiotic resistance]. Pathol Biol (Paris). 1988;36:442-5 pubmed
    Susceptibility to Augmentin (AUG) was studied as a function of resistance phenotypes toward amoxicillin (AMX), carbenicillin (CAR), cephalothin (CFT) and cefotaxime (CTX) for 1817 strains of Escherichia coli isolated at Henri-Mondor ..
  26. Kelly N, Falkiner F, Keane C, Murphy M, Fitzgerald M. The in-vitro activity of three anti-pseudomonal cephalosporins against isolates from patients with cystic fibrosis. J Antimicrob Chemother. 1981;8 Suppl B:175-8 pubmed
    ..These results were compared with the MICs of gentamicin and carbenicillin. Ceftazidime was the most active of the cephalosporins against Ps...
  27. Kumar R, Surendran P, Thampuran N. Analysis of antimicrobial resistance and plasmid profiles in Salmonella serovars associated with tropical seafood of India. Foodborne Pathog Dis. 2009;6:621-5 pubmed publisher
    ..susceptibility studies highlighted a comparatively high resistance in Salmonella isolates to sulfamethizol and carbenicillin, and moderate resistance to nalidixic acid and oxytetracycline...
  28. Liu X, Li Y, Guo Y, Zeng Z, Li B, Wood T, et al. Physiological Function of Rac Prophage During Biofilm Formation and Regulation of Rac Excision in Escherichia coli K-12. Sci Rep. 2015;5:16074 pubmed publisher
    ..coli K-12 leads to a functional change of TtcA, which results in reduced fitness in the presence of carbenicillin. Additionally, we demonstrate that YdaQ (renamed as XisR) is the excisionase of rac in E...
  29. Frost I, Smith W, Mitri S, Millán Á, Davit Y, Osborne J, et al. Cooperation, competition and antibiotic resistance in bacterial colonies. ISME J. 2018;12:1582-1593 pubmed publisher
    ..In contrast, selection for extracellular resistance to carbenicillin is weak in colonies, and high doses of antibiotic are required to select for resistance...
  30. Wang Q, Xu G, Li J. [Assay of R-plasmid and antibiotic resistance spectrum in 286 strains of gram-negative bacteria]. Zhonghua Liu Xing Bing Xue Za Zhi. 1994;15:357-9 pubmed
    ..Their major antibiotic resistance spectrum is: Ampicillin, Carbenicillin, Chloramphemicol, Gentamicin, Furbenicillin...
  31. Lawung R, Danielsson B, Prachayasittikul V, Bulow L. Calorimetric analysis of cephalosporins using an immobilized TEM-1 beta-lactamase on Ni2+ chelating sepharose fast flow. Anal Biochem. 2001;296:57-62 pubmed
    ..Moreover, Michaelis constants of the TEM-1 beta-lactamase were markedly increased upon immobilization for all substrates, especially carbenicillin, cephaloridine, and cefoperazone.
  32. Rao A, Ranganathan A. Interaction studies on proteins encoded by the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Mol Genet Genomics. 2004;272:571-9 pubmed
    ..Based on the present findings, a revised model for the processing of polyketides during the synthesis of PDIM is presented. ..
  33. Kaminski C, Timsit J, Dubois Y, Zahar J, Garrouste Orgeas M, Vesin A, et al. Impact of ureido/carboxypenicillin resistance on the prognosis of ventilator-associated pneumonia due to Pseudomonas aeruginosa. Crit Care. 2011;15:R112 pubmed publisher
  34. Kotsuji F, Hosokawa K, Takeuchi Y, Kamitani N, Tominaga T. Management of an infected urachal cyst during pregnancy. Asia Oceania J Obstet Gynaecol. 1994;20:355-9 pubmed
    ..The diagnosis and management of the infected urachal cyst complicating the pregnancy is discussed. ..
  35. Ariano R, Kassum D, Meatherall R, Patrick W. Lack of in vitro inactivation of tobramycin by imipenem/cilastatin. Ann Pharmacother. 1992;26:1075-7 pubmed
    ..Aliquots of tobramycin 10 micrograms/mL and carbenicillin 200 micrograms/mL were analyzed in the same manner, as a positive control...
  36. Palillo E, Salleh M. The patterns and transmissibility of antibiotic resistance among clinical strains of Pseudomonas aeruginosa. Microbiol Immunol. 1992;36:1195-200 pubmed
    ..predominantly pyocin-type 10 clinical strains of Pseudomonas aeruginosa were analyzed for resistance to carbenicillin, cefoperazone, cefotaxime, ceftazidime, gentamicin, amikacin and netilmicin...
  37. Jain M. Drug delivery through soft contact lenses. Br J Ophthalmol. 1988;72:150-4 pubmed
    ..were conducted on 466 patients waiting for senile cataract surgery and receiving chloromycetin, gentamicin, or carbenicillin subconjunctivally and through New Sauflon 70 and New Sauflon 85 lenses...
  38. Griggs D, Peake L, Johnson M, Ghori S, Mott A, Piddock L. Beta-lactamase-mediated beta-lactam resistance in Campylobacter species: prevalence of Cj0299 (bla OXA-61) and evidence for a novel beta-Lactamase in C. jejuni. Antimicrob Agents Chemother. 2009;53:3357-64 pubmed publisher
    ..all isolates were resistant to piperacillin (MICs >or= 256 microg/ml), and most were resistant to carbenicillin, cloxacillin, and cephalosporins...
  39. Duan F, Feng X, Jin Y, Liu D, Yang X, Zhou G, et al. Metal-carbenicillin framework-based nanoantibiotics with enhanced penetration and highly efficient inhibition of MRSA. Biomaterials. 2017;144:155-165 pubmed publisher
    ..construction of ?-lactam antibiotics and ?-lactamase inhibitors co-delivery of nanoantibiotics based on metal-carbenicillin framework-coated mesoporous silica nanoparticles (MSN) to overcome MRSA...
  40. Lee K, Lee K, Go J, Ryu J, Ryu J, Yoon S. The ferrichrome receptor A as a new target for Pseudomonas aeruginosa virulence attenuation. FEMS Microbiol Lett. 2016;363: pubmed publisher
    ..5000 mutants, a fiuA gene mutant was verified to form very defective biofilms in the presence of sub-MIC carbenicillin. The fiuA gene encodes ferrichrome receptor A, involved in the iron acquisition process...
  41. Hatch D, Overturf G. Delayed cerebrospinal fluid sterilization in infants with Hemophilus influenzae type b meningitis. J Infect Dis. 1989;160:711-5 pubmed
    ..Despite the in vitro antimicrobial susceptibility of H. influenzae type b to ceftizoxime and ceftazidime, delayed CSF sterilization may occur in infants receiving these antibiotics for bacterial meningitis...
  42. Tejedor Junco M, Gonzalez Martin M, Lupiola P, Gonzalez Lama Z. Type I beta-lactamases of Enterobacter cloacae and resistance to beta-lactam antibiotics. Folia Microbiol (Praha). 1998;43:683-6 pubmed
    ..Imipenem would therefore be the appropriate choice for therapy of infections caused by stably derepressed mutants of Enterobacter sp. producing type-I beta-lactamases. ..
  43. Naidong W, Dzerk A, Lee J. Development and validation of an LC method for the quantitation of carbenicillin in human serum. J Pharm Biomed Anal. 1994;12:845-50 pubmed
    An LC method for the quantitation of carbenicillin in human serum has been developed and validated. After protein precipitation with acetonitrile and evaporation, the residue was taken up by citric acid at pH 1.9...
  44. Bondaruk J, Curcio Vonlanthen V, Schneider C. Basic aspects related to penicillin-allergy skin testing: on the variability of the hapten-paratope interaction. Allergy. 1995;50:671-6 pubmed
    ..responses were characterized by ELISA and by ELISA inhibition using ampicillin, benzylpenicillin, and carbenicillin peptidic conjugates for coating and for inhibition...
  45. Feng J, Weitner M, Shi W, Zhang S, Sullivan D, Zhang Y. Identification of Additional Anti-Persister Activity against Borrelia burgdorferi from an FDA Drug Library. Antibiotics (Basel). 2015;4:397-410 pubmed publisher
    ..SV), thiostrepton, quinolone drugs (sarafloxacin, clinafloxacin, tosufloxacin), and cell wall inhibitors carbenicillin, tazobactam, aztreonam; antifungal agents such as fluconazole, mepartricin, bifonazole, climbazole, ..
  46. Rodante F, Vecchio S, Tomassetti M. Kinetic analysis of thermal decomposition for penicillin sodium salts: model-fitting and model-free methods. J Pharm Biomed Anal. 2002;29:1031-43 pubmed
    ..The failure in the model-fitting method did not allow calculating shelf life and half-life times. ..
  47. Blahova J, Kralikova K, Krcmery V, Chmelarova E, Torsová V. Two nosocomial strains of Stenotrophomonas maltophilia transferring antibiotic resistance to Proteus mirabilis P-38 recipient strain. J Chemother. 1998;10:22-4 pubmed
    In this report we describe a specific transfer of carbenicillin and cephaloridine resistance determinants from two different strains of Stenotrophomonas maltophilia: No...
  48. Vranes J, Schonwald S, Zagar Z. [Relation between P-fimbriae and resistance to amoxicillin, carbenicillin and tetracycline in uropathogenic strains of Escherichia coli]. Lijec Vjesn. 1994;116:178-81 pubmed
    ..P-fimbriated strains were more frequently resistant to tetracycline and carbenicillin than strains in which P-fimbriae were not detected, and they all were resistant to amoxicillin, in contrast ..
  49. Belal F, Rizk M, Eid M. Polarographic determination of some penicillins through nitrosation. J Pharm Biomed Anal. 1998;17:275-82 pubmed
    ..DPP were used for the determination of three penicillins, namely, ampicillin, benzylpenicillin and carbenicillin, in pure form and in their dosage forms...
  50. Lan M, Liu W, Ge J, Wu J, Wang H, Zhang W, et al. A polythiophene-derived ratiometric fluorescent sensor for highly sensitive determination of carbenicillin in aqueous solution. Chem Commun (Camb). 2012;48:6818-20 pubmed publisher
    A new ratiometric fluorescent sensor based on a quaternized quinine substituted 3-phenylpolythiophene derivative (PTQ1) was designed and developed for facile and reliable detection of carbenicillin with high sensitivity and selectivity.
  51. Daniels T, Mills N, Whitaker P. Nebuliser systems for drug delivery in cystic fibrosis. Cochrane Database Syst Rev. 2013;:CD007639 pubmed publisher
  52. Isaac Márquez A, Lezama Dávila C, Eslava Campos C, Navarro Ocaña A, Cravioto Quintana A. Serotypes of Vibrio cholerae non-O1 isolated from water supplies for human consumption in Campeche, México and their antibiotic susceptibility pattern. Mem Inst Oswaldo Cruz. 1998;93:17-22 pubmed
    ..60% and 53.8% of all studied strains of V. cholerae non-O1 proved to be resistant to ampicillin and carbenicillin. 3.1%, 7.7% and 6...
  53. Bej A, Perlin M, Atlas R. Model suicide vector for containment of genetically engineered microorganisms. Appl Environ Microbiol. 1988;54:2472-7 pubmed
    ..The vector plasmid also codes for carbenicillin resistance...