methicillin

Summary

Summary: One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.

Top Publications

  1. Memmi G, Nair D, Cheung A. Role of ArlRS in autolysis in methicillin-sensitive and methicillin-resistant Staphylococcus aureus strains. J Bacteriol. 2012;194:759-67 pubmed publisher
    ..including ArlRS, a two component regulatory system that has been shown to negatively regulate autolysis in methicillin-sensitive Staphylococcus aureus (MSSA) strains...
  2. Fujimura T, Murakami K. Staphylococcus aureus clinical isolate with high-level methicillin resistance with an lytH mutation caused by IS1182 insertion. Antimicrob Agents Chemother. 2008;52:643-7 pubmed
    ..that deficiency of the lytH gene, whose product is homologous to lytic enzymes, caused the elevation of methicillin resistance in Staphylococcus aureus strain SR17238, a strain of S...
  3. Nannini E, Stryjewski M, Singh K, Rude T, Corey G, Fowler V, et al. Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus. Antimicrob Agents Chemother. 2010;54:2206-8 pubmed publisher
    Using 98 clinical methicillin-susceptible Staphylococcus aureus isolates of known beta-lactamase (Bla) type, we found a pronounced inoculum effect for cephalexin (mostly Bla type A and C strains), a mild inoculum effect for cephalothin (..
  4. Enkhbaatar P, Joncam C, Traber L, Nakano Y, Wang J, Lange M, et al. Novel ovine model of methicillin-resistant Staphylococcus aureus-induced pneumonia and sepsis. Shock. 2008;29:642-9 pubmed
    b>Methicillin-resistant Staphylococcus aureus (MRSA)-related pneumonia and/or sepsis are a frequent serious menace...
  5. Freidlin J, Acharya N, Lietman T, Cevallos V, Whitcher J, Margolis T. Spectrum of eye disease caused by methicillin-resistant Staphylococcus aureus. Am J Ophthalmol. 2007;144:313-5 pubmed
    To compare the clinical features and antibiotic susceptibility of ocular methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA). Cross-sectional study...
  6. Werbick C, Becker K, Mellmann A, Juuti K, von Eiff C, Peters G, et al. Staphylococcal chromosomal cassette mec type I, spa type, and expression of Pls are determinants of reduced cellular invasiveness of methicillin-resistant Staphylococcus aureus isolates. J Infect Dis. 2007;195:1678-85 pubmed
    We have shown previously that pls, which codes for the surface protein Pls of methicillin-resistant Staphylococcus aureus (MRSA), reduces adhesion to immobilized fibronectin, fibrinogen, laminin, and immunoglobulin G as well as invasion ..
  7. Hesje C, Sanfilippo C, Haas W, Morris T. Molecular epidemiology of methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolated from the eye. Curr Eye Res. 2011;36:94-102 pubmed publisher
    b>Methicillin-resistant Staphylococcus aureus (MRSA) strains are commonly classified as hospital-acquired (HA) or community-acquired (CA)...
  8. Chen K, Campbell H, Borrell L, Huard R, Saiman L, Della Latta P. Predictors and outcomes for pregnant women with vaginal-rectal carriage of community-associated methicillin-resistant Staphylococcus aureus. Am J Perinatol. 2007;24:235-40 pubmed
    ..to determine the predictors and outcomes of pregnant women with vaginal-rectal carriage of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA)...
  9. Kristof K, Kocsis E, Szabo D, Kardos S, Cser V, Nagy K, et al. Significance of methicillin-teicoplanin resistant Staphylococcus haemolyticus in bloodstream infections in patients of the Semmelweis University hospitals in Hungary. Eur J Clin Microbiol Infect Dis. 2011;30:691-9 pubmed publisher

More Information

Publications81

  1. Moreira Osório T, Delle Monache F, Domeneghini Chiaradia L, Mascarello A, Regina Stumpf T, Roberto Zanetti C, et al. Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus. Bioorg Med Chem Lett. 2012;22:225-30 pubmed publisher
    ..dihydrochalcones, hydrazones and oxadiazoles were tested against Staphylococcus aureus ATCC 25923 and methicillin-resistant S...
  2. Huang S, Rifas Shiman S, Warren D, Fraser V, Climo M, Wong E, et al. Improving methicillin-resistant Staphylococcus aureus surveillance and reporting in intensive care units. J Infect Dis. 2007;195:330-8 pubmed
    Routine culturing of patients in intensive care units (ICUs) for methicillin-resistant Staphylococcus aureus (MRSA) identifies unrecognized carriers and facilitates timely isolation...
  3. Zubeir I, Kanbar T, Alber J, Lammler C, Akineden O, Weiss R, et al. Phenotypic and genotypic characteristics of methicillin/oxacillin-resistant Staphylococcus intermedius isolated from clinical specimens during routine veterinary microbiological examinations. Vet Microbiol. 2007;121:170-6 pubmed
    b>Methicillin/oxacillin resistance of 10 S. intermedius strains was investigated by conventional and molecular methods...
  4. Gomes A, Westh H, de Lencastre H. Origins and evolution of methicillin-resistant Staphylococcus aureus clonal lineages. Antimicrob Agents Chemother. 2006;50:3237-44 pubmed
    Most methicillin-resistant Staphylococcus aureus (MRSA) isolates identified among blood isolates collected in Denmark between 1957 and 1970 belonged to either phage group III or the closely related 83A complex and had a PSTM antibiotype (..
  5. Pape J, Wadlin J, Nachamkin I. Use of BBL CHROMagar MRSA medium for identification of methicillin-resistant Staphylococcus aureus directly from blood cultures. J Clin Microbiol. 2006;44:2575-6 pubmed
    We evaluated the ability of BBL CHROMagar MRSA medium (Becton Dickinson, Sparks, MD) to identify methicillin-resistant Staphylococcus aureus (MRSA) directly upon subculture from positive blood culture bottles...
  6. Bruins M, Juffer P, Wolfhagen M, Ruijs G. Salt tolerance of methicillin-resistant and methicillin-susceptible Staphylococcus aureus. J Clin Microbiol. 2007;45:682-3 pubmed
  7. Kondo Y, Ito T, Ma X, Watanabe S, Kreiswirth B, Etienne J, et al. Combination of multiplex PCRs for staphylococcal cassette chromosome mec type assignment: rapid identification system for mec, ccr, and major differences in junkyard regions. Antimicrob Agents Chemother. 2007;51:264-74 pubmed
    ..in combination with genotyping of the Staphylococcus aureus chromosome, has become essential for defining methicillin-resistant S. aureus (MRSA) clones in epidemiological studies...
  8. Shane A, Hansen N, Stoll B, Bell E, Sanchez P, Shankaran S, et al. Methicillin-resistant and susceptible Staphylococcus aureus bacteremia and meningitis in preterm infants. Pediatrics. 2012;129:e914-22 pubmed publisher
    Data are limited on the impact of methicillin-resistant Staphylococcus aureus (MRSA) on morbidity and mortality among very low birth weight (VLBW) infants with S aureus (SA) bacteremia and/or meningitis (B/M)...
  9. Young B, Golubchik T, Batty E, Fung R, Larner Svensson H, Votintseva A, et al. Evolutionary dynamics of Staphylococcus aureus during progression from carriage to disease. Proc Natl Acad Sci U S A. 2012;109:4550-5 pubmed publisher
    ..accompany the transition from nasal carriage to fatal bloodstream infection in an individual colonized with methicillin-sensitive S. aureus...
  10. Davis M, Baron P, Price L, Williams D, Jeyaseelan S, Hambleton I, et al. Dry collection and culture methods for recovery of methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains from indoor home environments. Appl Environ Microbiol. 2012;78:2474-6 pubmed publisher
    ..Using laboratory experiments and application to homes of asthmatic children in Barbados, we characterize microbiological methods adapted for settings with transportation delays between sampling and initiation of culture. ..
  11. Hanaki K, Sekiguchi J, Shimada K, Sato A, Watari H, Kojima T, et al. Loop-mediated isothermal amplification assays for identification of antiseptic- and methicillin-resistant Staphylococcus aureus. J Microbiol Methods. 2011;84:251-4 pubmed publisher
    A method for rapid identification of antiseptic- and methicillin-resistant Staphylococcus aureus (MRSA) based on 3 loop-mediated isothermal amplification (LAMP) assays was developed. LAMP targeting the femB gene identified S...
  12. Matiz C, Tom W, Eichenfield L, Pong A, Friedlander S. Children with atopic dermatitis appear less likely to be infected with community acquired methicillin-resistant Staphylococcus aureus: the San Diego experience. Pediatr Dermatol. 2011;28:6-11 pubmed publisher
    Given the increasing rate of community-acquired methicillin resistant Staphylococcus aureus skin infections in the population, such infections might be concurrently increasing in patients with atopic dermatitis...
  13. Bemis D, Jones R, Videla R, Kania S. Evaluation of cefoxitin disk diffusion breakpoint for detection of methicillin resistance in Staphylococcus pseudintermedius isolates from dogs. J Vet Diagn Invest. 2012;24:964-7 pubmed publisher
    Cefoxitin disk diffusion susceptibility testing is a recommended screening method for the detection of methicillin resistance in human isolates of Staphylococcus aureus and coagulase-negative staphylococci...
  14. Xiong Y, Hady W, Bayer A, Chen L, Kreiswirth B, Yang S. Telavancin in therapy of experimental aortic valve endocarditis in rabbits due to daptomycin-nonsusceptible methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2012;56:5528-33 pubmed publisher
    A number of cases of both methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) strains that have developed daptomycin resistance (DAP-R) have been reported...
  15. Lemaire S, Olivier A, Van Bambeke F, Tulkens P, Appelbaum P, Glupczynski Y. Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics. Antimicrob Agents Chemother. 2008;52:2797-805 pubmed publisher
    Staphylococcus aureus invades eukaryotic cells. When methicillin-resistant S...
  16. Mancao M, Estrada B, Wilson F, Figarola M, Wesenberg R. Methicillin-resistant Staphylococcus aureus hepatic abscess in a patient with sickle-cell disease. Int J Lab Hematol. 2007;29:474-7 pubmed
    We report a case of a 16-year-old female patient with sickle-cell disease with a liver abscess secondary to methicillin-resistant Staphylococcus aureus (MRSA)...
  17. Louie A, Liu W, Kulawy R, Drusano G. In vivo pharmacodynamics of torezolid phosphate (TR-701), a new oxazolidinone antibiotic, against methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains in a mouse thigh infection model. Antimicrob Agents Chemother. 2011;55:3453-60 pubmed publisher
    ..the oxazolidinone TR-700 which demonstrates potent in vitro activity against Gram-positive bacteria, including methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA)...
  18. Jonkam C, Lange M, Traber D, Maybauer D, Maybauer M, Bansal K, et al. Cardiovascular collapse and vascular permeability changes in an ovine model of methicillin-resistant Staphylococcus aureus sepsis. Shock. 2009;32:621-5 pubmed publisher
    b>Methicillin-resistant Staphylococcus aureus (MRSA) infections with severe outcomes such as sepsis and septic shock are progressively increasing in both the community and in hospital settings...
  19. Windahl U, Reimegård E, Holst B, Egenvall A, Fernström L, Fredriksson M, et al. Carriage of methicillin-resistant Staphylococcus pseudintermedius in dogs--a longitudinal study. BMC Vet Res. 2012;8:34 pubmed publisher
    b>Methicillin-resistant S. pseudintermedius strains (MRSP) are reported with increasing frequency in bacterial cultures from dogs...
  20. Unnerstad H, Bengtsson B, Horn af Rantzien M, Borjesson S. Methicillin-resistant Staphylococcus aureus containing mecC in Swedish dairy cows. Acta Vet Scand. 2013;55:6 pubmed publisher
    Hitherto, methicillin-resistant Staphylococcus aureus (MRSA) has not been detected in Swedish cattle...
  21. Hill E, Peetermans W, Vanderschueren S, Claus P, Herregods M, Herijgers P. Methicillin-resistant versus methicillin-sensitive Staphylococcus aureus infective endocarditis. Eur J Clin Microbiol Infect Dis. 2008;27:445-50 pubmed publisher
    The incidence of methicillin-resistant Staphylococcus aureus (MRSA) infective endocarditis (IE) is increasing. This study compared clinical characteristics and mortality in patients with methicillin-sensitive S...
  22. Kadlec K, Schwarz S. Identification of the novel dfrK-carrying transposon Tn559 in a porcine methicillin-susceptible Staphylococcus aureus ST398 strain. Antimicrob Agents Chemother. 2010;54:3475-7 pubmed publisher
    ..to be part of the novel Tn554-related transposon Tn559 integrated in the chromosomal radC gene of a porcine methicillin-susceptible Staphylococcus aureus ST398 strain...
  23. Tsai H, Chao P, Sy C, Lee S, Chen Y, Wann S, et al. Community-associated methicillin-resistant Staphylococcus aureus infective endocarditis with Panton-Valentine leukocidin gene in an injection drug user with HIV infection. Intern Med. 2008;47:1485-9 pubmed
    Reports of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) isolates carrying Panton-Valentine leukocidin (PVL) gene that causes infective endocarditis in injection drug users (IDUs) with human immunodeficiency ..
  24. Kilic A, Basustaoglu A. Double triplex real-time PCR assay for simultaneous detection of Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus hominis, and Staphylococcus haemolyticus and determination of their methicillin resistance directly from positive blood. Res Microbiol. 2011;162:1060-6 pubmed publisher
    ..aureus, Staphylococcus epidermidis, Staphylococcus hominis, Staphylococcus haemolyticus and their methicillin resistance in a single reaction directly from Gram-positive cocci-in-clusters (GPCs)-positive blood culture ..
  25. Fukaya Y, Kurita A, Tsuruga H, Naito A, Nakaya S, Sato M, et al. Antibiotic effects of WP-0405, a thermo-setting ofloxacin gel, on methicillin-resistant Staphylococcus aureus keratitis in rabbits. J Ocul Pharmacol Ther. 2006;22:258-66 pubmed
    ..3% ofloxacin-containing ophthalmic gel) and ofloxacin (a conventional 0.3% ofloxacin solution) on methicillin-resistant Staphylococcus aureus (MRSA) keratitis were compared in a rabbit model...
  26. Havaei S, Vidovic S, Tahmineh N, Mohammad K, Mohsen K, Starnino S, et al. Epidemic methicillin-susceptible Staphylococcus aureus lineages are the main cause of infections at an Iranian university hospital. J Clin Microbiol. 2011;49:3990-3 pubmed publisher
    The majority of Staphylococcus aureus infections from Isfahan, Iran, were caused by epidemic methicillin-susceptible S. aureus (MSSA) lineages, sequence type 8 (ST8), ST22, ST30, and ST6. The predominant methicillin-resistant S...
  27. Ben Slama K, Gharsa H, Klibi N, Jouini A, Lozano C, Gómez Sanz E, et al. Nasal carriage of Staphylococcus aureus in healthy humans with different levels of contact with animals in Tunisia: genetic lineages, methicillin resistance, and virulence factors. Eur J Clin Microbiol Infect Dis. 2011;30:499-508 pubmed publisher
    ..b>Methicillin-resistant Staphylococcus aureus (MRSA) was detected in one of these 423 samples (0...
  28. Lee Y, Kim C, Kim M, Yong D, Lee K, Chong Y. [Detection of mecA in strains with oxacillin and cefoxitin disk tests for detection of methicillin-resistant Staphylococcus]. Korean J Lab Med. 2007;27:276-80 pubmed
    ..Institute (CLSI) recommends the use of cefoxitin disks instead of long-used oxacillin disks for screening methicillin-resistant isolates of staphylococci...
  29. Fenner L, Widmer A, Frei R. Molecular epidemiology of invasive methicillin-susceptible Staphylococcus aureus strains circulating at a Swiss University Hospital. Eur J Clin Microbiol Infect Dis. 2008;27:623-6 pubmed publisher
    In contrast to methicillin-resistant Staphylococcus aureus, little is known of the distribution of spa types among methicillin-susceptible S. aureus (MSSA)...
  30. Blomquist P. Methicillin-resistant Staphylococcus aureus infections of the eye and orbit (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc. 2006;104:322-45 pubmed
    To ascertain if methicillin-resistant Staphylococcus aureus (MRSA) ophthalmic infections are increasing...
  31. Orscheln R, Hunstad D, Fritz S, Loughman J, Mitchell K, Storch E, et al. contribution of genetically restricted, methicillin-susceptible strains to the ongoing epidemic of community-acquired Staphylococcus aureus infections. Clin Infect Dis. 2009;49:536-42 pubmed publisher
    ..worldwide epidemic of community-acquired Staphylococcus aureus infections, attention has focused on the role of methicillin-resistant strains. We characterize methicillin-susceptible strains that also contribute to this epidemic...
  32. Hughes D, Frei C, Maxwell P, Green K, Patterson J, Crawford G, et al. Continuous versus intermittent infusion of oxacillin for treatment of infective endocarditis caused by methicillin-susceptible Staphylococcus aureus. Antimicrob Agents Chemother. 2009;53:2014-9 pubmed publisher
    ..outcomes between CI oxacillin and intermittent-infusion (II) oxacillin in the treatment of IE caused by methicillin-susceptible Staphylococcus aureus (MSSA)...
  33. Wardyn S, Forshey B, Smith T. High prevalence of Panton-Valentine leukocidin among methicillin-sensitive Staphylococcus aureus colonization isolates in rural Iowa. Microb Drug Resist. 2012;18:427-33 pubmed publisher
    ..Nasal and throat swabs were collected and plated onto selective media to isolate methicillin-susceptible and methicillin-resistant S...
  34. Pawlak J, Johnson L, Bonilla H, Saravolatz L, Fakih M, Fugelli A, et al. In vitro activities of LTX-109, a synthetic antimicrobial peptide, against methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, daptomycin-nonsusceptible, and linezolid-nonsusceptible Staphylococcus aureus. Antimicrob Agents Chemother. 2012;56:4478-82 pubmed publisher
    LTX-109 and eight other antimicrobial agents were evaluated against 155 methicillin-resistant Staphylococcus aureus (MRSA) isolates, including strains resistant to vancomycin and strains with decreased susceptibility to daptomycin and ..
  35. Skiest D, Brown K, Cooper T, Hoffman Roberts H, Mussa H, Elliott A. Prospective comparison of methicillin-susceptible and methicillin-resistant community-associated Staphylococcus aureus infections in hospitalized patients. J Infect. 2007;54:427-34 pubmed
    We sought to determine the proportion of community-associated Staphylococcus aureus infections due to methicillin-resistant S. aureus (CA-MRSA) at a large county hospital...
  36. Mostofsky E, Lipsitch M, Regev Yochay G. Is methicillin-resistant Staphylococcus aureus replacing methicillin-susceptible S. aureus?. J Antimicrob Chemother. 2011;66:2199-214 pubmed publisher
    Despite extensive research on the emergence of and treatments for methicillin-resistant Staphylococcus aureus (MRSA), prior studies have not rigorously evaluated the impact of methicillin resistance on the overall incidence of S...
  37. Boyle Vavra S, Yin S, Jo D, Montgomery C, Daum R. VraT/YvqF is required for methicillin resistance and activation of the VraSR regulon in Staphylococcus aureus. Antimicrob Agents Chemother. 2013;57:83-95 pubmed publisher
    Staphylococcus aureus infections caused by strains that are resistant to all forms of penicillin, so-called methicillin-resistant S. aureus (MRSA) strains, have become common...
  38. van Duijkeren E, Catry B, Greko C, Moreno M, Pomba M, Pyörälä S, et al. Review on methicillin-resistant Staphylococcus pseudintermedius. J Antimicrob Chemother. 2011;66:2705-14 pubmed publisher
    ..Since 2006 there has been a significant emergence of methicillin-resistant S. pseudintermedius (MRSP) mainly due to clonal spread...
  39. Chang Y, Chen W, Hsieh P, Chen D, Lee M, Shih H, et al. In vitro activities of daptomycin-, vancomycin-, and teicoplanin-loaded polymethylmethacrylate against methicillin-susceptible, methicillin-resistant, and vancomycin-intermediate strains of Staphylococcus aureus. Antimicrob Agents Chemother. 2011;55:5480-4 pubmed publisher
    ..of polymethylmethacrylate (PMMA) bone cements loaded with daptomycin, vancomycin, and teicoplanin against methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-..
  40. van der Mee Marquet N, Epinette C, Loyau J, Arnault L, Domelier A, Losfelt B, et al. Staphylococcus aureus strains isolated from bloodstream infections changed significantly in 2006. J Clin Microbiol. 2007;45:851-7 pubmed
    ..This was largely due to an increase in BSI involving methicillin-sensitive S. aureus (MSSA) strains and nonmultiresistant methicillin-resistant S. aureus (NORSA) strains...
  41. Hallin M, Deplano A, Denis O, De Mendonca R, De Ryck R, Struelens M. Validation of pulsed-field gel electrophoresis and spa typing for long-term, nationwide epidemiological surveillance studies of Staphylococcus aureus infections. J Clin Microbiol. 2007;45:127-33 pubmed
    ..fragments has been used by the Belgian Reference Laboratory for Staphylococci for national hospital surveys of methicillin-resistant Staphylococcus aureus since 1992...
  42. Lloyd Smith E, Hull M, Hawkins D, Champagne S, Kerr T, Romney M. Screening for methicillin-resistant Staphylococcus aureus (MRSA) in community-recruited injection drug users: are throat swabs necessary?. Epidemiol Infect. 2012;140:1721-4 pubmed publisher
    ..Thirty-seven (20%) were positive for MRSA: most (34, 92%) were carriers in the nares; while only three (8%) were carriers detected by throat swabs alone. The majority (29, 78%) of MRSA isolates were PVL positive. ..
  43. Shore A, Rossney A, O Connell B, Herra C, Sullivan D, Humphreys H, et al. Detection of staphylococcal cassette chromosome mec-associated DNA segments in multiresistant methicillin-susceptible Staphylococcus aureus (MSSA) and identification of Staphylococcus epidermidis ccrAB4 in both methicillin-resistant S. aureus and MSS. Antimicrob Agents Chemother. 2008;52:4407-19 pubmed publisher
    b>Methicillin-susceptible Staphylococcus aureus (MSSA) can arise from methicillin-resistant S. aureus (MRSA) following partial or complete excision of staphylococcal cassette chromosome mec (SCCmec)...
  44. Clouse F, Hovde L, Rotschafer J. In vitro evaluation of the activities of telavancin, cefazolin, and vancomycin against methicillin-susceptible and methicillin-resistant Staphylococcus aureus in peritoneal dialysate. Antimicrob Agents Chemother. 2007;51:4521-4 pubmed
    ..The results showed that telavancin exhibited statistically significantly better kill (P < 0.05) against both methicillin-susceptible and methicillin-resistant Staphylococcus aureus.
  45. Morrow B, Abbanat D, Baum E, Crespo Carbone S, Davies T, He W, et al. Antistaphylococcal activities of the new fluoroquinolone JNJ-Q2. Antimicrob Agents Chemother. 2011;55:5512-21 pubmed publisher
    ..fluoroquinolone JNJ-Q2 displays in vitro activity against Gram-negative and Gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA) and ciprofloxacin-resistant MRSA isolates...
  46. Al Nakib M, Réglier Poupet H, Longo M, Adam J, Raymond J, Zambardi G, et al. Methicillin-resistant Staphylococcus aureus expressing low-level methicillin resistance may not be detected by the VITEK2® system. Diagn Microbiol Infect Dis. 2012;72:193-5 pubmed publisher
    Low-level methicillin-resistant Staphylococcus aureus may be difficult to detect with the VITEK® 2 system (VK2). Here, we suggest that S...
  47. Oliveira A, D Azevedo P, de Sousa L, Viana Niero C, Francisco W, Lottenberg C, et al. Laboratory detection methods for methicillin resistance in coagulase negative Staphylococcus isolated from ophthalmic infections. Arq Bras Oftalmol. 2007;70:667-75 pubmed
    ..We believe it is important to have available methods that accurately detect methicillin resistance of the less commonly encountered species, chiefly because of their increasing importance as ..
  48. Elizur A, Orscheln R, Ferkol T, Atkinson J, Dunne W, Buller R, et al. Panton-Valentine Leukocidin-positive methicillin-resistant Staphylococcus aureus lung infection in patients with cystic fibrosis. Chest. 2007;131:1718-25 pubmed
    Panton-Valentine Leukocidin-expressing (PVL+) methicillin-resistant Staphylococcus aureus (MRSA) is an emerging pathogen worldwide causing fatal necrotizing pneumonias in otherwise healthy individuals but has not been described in ..
  49. Davis S, Perri M, Donabedian S, Manierski C, Singh A, Vager D, et al. Epidemiology and outcomes of community-associated methicillin-resistant Staphylococcus aureus infection. J Clin Microbiol. 2007;45:1705-11 pubmed
    Over a 2-year period (2003 to 2005) patients with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and community-acquired methicillin-susceptible Staphylococcus aureus (CA-MSSA) infections were prospectively ..
  50. Marks L, Clementi E, Hakansson A. Sensitization of Staphylococcus aureus to methicillin and other antibiotics in vitro and in vivo in the presence of HAMLET. PLoS ONE. 2013;8:e63158 pubmed publisher
    ..HAMLET acts as an antimicrobial adjuvant that can increase the activity of a broad spectrum of antibiotics (methicillin, vancomycin, gentamicin and erythromycin) against multi-drug resistant Staphylococcus aureus, to a degree where ..
  51. Yadegar A, Sattari M, Mozafari N, Goudarzi G. Prevalence of the genes encoding aminoglycoside-modifying enzymes and methicillin resistance among clinical isolates of Staphylococcus aureus in Tehran, Iran. Microb Drug Resist. 2009;15:109-13 pubmed publisher
    ..encoding the most clinically prevalent aminoglycoside-modifying enzymes, and simultaneous detection of the methicillin resistance gene, mecA, in Staphylococcus aureus isolates. A total of 100 S...
  52. Nickerson E, Wuthiekanun V, Kumar V, Amornchai P, Wongdeethai N, Chheng K, et al. Emergence of community-associated methicillin-resistant Staphylococcus aureus carriage in children in Cambodia. Am J Trop Med Hyg. 2011;84:313-7 pubmed publisher
    We previously described the first reported isolation of methicillin-resistant Staphylococcus aureus (MRSA) (a case series of pediatric community-associated MRSA infections) in Cambodia...
  53. Noto M, Archer G. A subset of Staphylococcus aureus strains harboring staphylococcal cassette chromosome mec (SCCmec) type IV is deficient in CcrAB-mediated SCCmec excision. Antimicrob Agents Chemother. 2006;50:2782-8 pubmed publisher
    ..mobile in the environment, and this mobility may be partially responsible for the rise in community-associated methicillin-resistant staphylococcal infections...
  54. Catena V, Baiocchi M, Lentini P, Badolati L, Baccarin M, Del Monte D, et al. Necrotizing pneumonia caused by Panton-Valentine leukocidin-producing methicillin-susceptible Staphylococcus aureus (MSSA). Infez Med. 2012;20:205-10 pubmed
    ..This report documents a confirmed case of necrotizing pneumonia due to methicillin-susceptible S. aureus (MSSA) harbouring Panton-Valentine leukocidin genes...
  55. De Neeling A, van den Broek M, Spalburg E, van Santen Verheuvel M, Dam Deisz W, Boshuizen H, et al. High prevalence of methicillin resistant Staphylococcus aureus in pigs. Vet Microbiol. 2007;122:366-72 pubmed
    Recently methicillin resistant Staphylococcus aureus (MRSA) was isolated from pigs and pig farmers in The Netherlands...
  56. Breurec S, Fall C, Pouillot R, Boisier P, Brisse S, Diene Sarr F, et al. Epidemiology of methicillin-susceptible Staphylococcus aureus lineages in five major African towns: high prevalence of Panton-Valentine leukocidin genes. Clin Microbiol Infect. 2011;17:633-9 pubmed publisher
    The epidemiology of methicillin-susceptible Staphylococcus aureus (MSSA) in Africa is poorly documented. From January 2007 to March 2008, 555 S...
  57. von Ah U, Wirz D, Daniels A. Rapid differentiation of methicillin-susceptible Staphylococcus aureus from methicillin-resistant S. aureus and MIC determinations by isothermal microcalorimetry. J Clin Microbiol. 2008;46:2083-7 pubmed publisher
    In this study, the use of isothermal microcalorimetry (IMC) for differentiation between methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) and MIC determination was evaluated...
  58. Kwon N, Park K, Jung W, Youn H, Lee Y, Kim S, et al. Characteristics of methicillin resistant Staphylococcus aureus isolated from chicken meat and hospitalized dogs in Korea and their epidemiological relatedness. Vet Microbiol. 2006;117:304-12 pubmed
    b>Methicillin resistant Staphylococcus aureus (MRSA) is one of the most important pathogens in human and veterinary hospitals. The isolation of MRSA from animals and foodstuffs has been reported with an increased incidence...
  59. Leblanc L, Pepin J, Toulouse K, Ouellette M, Coulombe M, Corriveau M, et al. Fluoroquinolones and risk for methicillin-resistant Staphylococcus aureus, Canada. Emerg Infect Dis. 2006;12:1398-405 pubmed
    ..To determine the role of antimicrobial drugs in facilitating healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) colonization and infection and to compare this role with their effects ..
  60. Sakoulas G, Rose W, Rybak M, Pillai S, Alder J, Moellering R, et al. Evaluation of endocarditis caused by methicillin-susceptible Staphylococcus aureus developing nonsusceptibility to daptomycin. J Clin Microbiol. 2008;46:220-4 pubmed
    We examined sequential methicillin-susceptible Staphylococcus aureus isolates from a patient with mitral valve endocarditis recovered during persistent bacteremia on standard therapy and relapse after treatment with daptomycin...
  61. Thati V, Shivannavar C, Gaddad S. Vancomycin resistance among methicillin resistant Staphylococcus aureus isolates from intensive care units of tertiary care hospitals in Hyderabad. Indian J Med Res. 2011;134:704-8 pubmed publisher
    Multidrug resistant methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of nosocomial and community acquired infections and is on the rise...
  62. Chen C, Su L, Lin T, Huang Y. Molecular analysis of repeated methicillin-resistant Staphylococcus aureus infections in children. PLoS ONE. 2010;5:e14431 pubmed publisher
    b>Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen that causes severe morbidity and mortality in hospitalized patients...
  63. Kaltsas A, Guh A, Mediavilla J, Varshney A, Robiou N, Gialanellia P, et al. Frequency of panton-valentine leukocidin-producing methicillin-sensitive Staphylococcus strains in patients with complicated skin and soft tissue infection in bronx, new york. J Clin Microbiol. 2011;49:2992-5 pubmed publisher
    lukF-PV was present in 36% of skin and soft tissue infection (SSTI)-derived methicillin-susceptible Staphylococcus aureus (MSSA) strains and comprised six distinct clones, which contained fewer enterotoxin genes than strains without lukF-..
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    ..0.014 in 2010). ST398 BSI isolates differed from the pig-borne multiresistant clone: 17/18 BSI isolates were methicillin susceptible and none was of t011, t034 or t108 pig-borne spa-types...
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    Various types of the staphylococcal cassette chromosome mec (SCCmec) are known to confer methicillin resistance on the human pathogen Staphylococcus aureus. Such cassettes are not always stably maintained...
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    The epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) infections, in particular with Panton-Valentine leukocidin (PVL)-positive strains, has not been well characterized in children and young adults with HIV infection...
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    b>Methicillin-resistant Staphylococcus aureus (MRSA) remains a major human pathogen...
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    We report 2 outbreaks of Panton-Valentine leukocidin-positive, doxycycline-resistant, methicillin-susceptible Staphylococcus aureus infections in French soldiers operating in Côte d'Ivoire...
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    ..arcA was also detected in selected methicillin-susceptible USA300 and methicillin-resistant USA100 isolates...
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    b>Methicillin-resistant Staphylococcus aureus (MRSA) USA300 is a predominant cause of community-acquired (CA) infection in the United States...