cyclacillin

Summary

Summary: A cyclohexylamido analog of PENICILLANIC ACID.

Top Publications

  1. Mizen L, Berry V, Woodnutt G. The influence of uptake from the gastrointestinal tract and first-pass effect on oral bioavailability of (Z)-alkyloxyimino penicillins. J Pharm Pharmacol. 1995;47:725-30 pubmed
    ..penicillins were able to pass across the mucosal epithelium although to a lesser extent than amoxycillin and cyclacillin, both of which exhibit excellent oral bioavailability in man and animals...
  2. Irie M, Terada T, Okuda M, Inui K. Efflux properties of basolateral peptide transporter in human intestinal cell line Caco-2. Pflugers Arch. 2004;449:186-94 pubmed
    ..The behaviour of Gly-Sar in Caco-2 cells could be predicted by a mathematical model describing the peptide transporters. ..
  3. Margarit F, Moreno Dalmau J, Obach R, Peraire C, Pla Delfina J. Intestinal absorption kinetics of a series of aminopenicillins and azidocillin. A comparative study in the rat. Eur J Drug Metab Pharmacokinet. 1991;Spec No 3:102-7 pubmed
    Intestinal absorption rate constants of amoxicillin, ampicillin, epicillin, cyclacillin and azidocillin, by means of a static in situ intestinal perfusion method has been estimated...
  4. Ganapathy M, Brandsch M, Prasad P, Ganapathy V, Leibach F. Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. J Biol Chem. 1995;270:25672-7 pubmed
    ..The substrate recognition pattern of PEPT 1 and PEPT 2 was studied with cefadroxil (a cephalosporin) and cyclacillin (a penicillin) as model substrates for the peptide transporters constitutively expressed in Caco-2 cells (PEPT ..
  5. Oh D M -, Sinko P, Amidon G. Characterization of the oral absorption of several aminopenicillins: determination of intrinsic membrane absorption parameters in the rat intestine in situ. Int J Pharm. 1992;85:181-7 pubmed
    ..088 for amoxicillin; and Jmax* = 16.30 +/- 3.40 mM, Km = 14.00 +/- 3.30 mM, Pm* = 0, Pc* = 1.14 +/- 0.05 for cyclacillin. All of the aminopenicillins studied demonstrated saturable absorption kinetics as indicated by their ..
  6. Sabolic I, Asif A, Budach W, Wanke C, Bahn A, Burckhardt G. Gender differences in kidney function. Pflugers Arch. 2007;455:397-429 pubmed
  7. Terada T, Saito H, Mukai M, Inui K. Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. Am J Physiol. 1997;273:F706-11 pubmed
    ..b>Cyclacillin (aminopenicillin) and ceftibuten (anionic cephalosporin without an alpha-amino group) showed potent inhibitory ..