cephaloridine

Summary

Summary: A cephalosporin antibiotic.

Top Publications

  1. Kawai Y, Kohda Y, Kodawara T, Gemba M. Protective effect of a protein kinase inhibitor on cellular injury induced by cephaloridine in the porcine kidney cell line LLC-PK(1). J Toxicol Sci. 2005;30:157-63 pubmed
    ..the effects of a protein kinase C inhibitor and a tyrosine kinase inhibitor on the cellular injury induced by cephaloridine in an established renal epithelial cell line, LLC-PK(1)...
  2. Jung K, Takeda M, Shimoda M, Narikawa S, Tojo A, Kim D, et al. Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci. 2002;70:1861-74 pubmed
    This study was performed to elucidate the possible involvement of organic anion transporter 3 (OAT3) in cephaloridine (CER)-induced nephrotoxicity and compare the substrate specificity between rOAT3 and rat OAT1 (rOAT1) for various ..
  3. Yokozawa T, Owada S. Effect of ginsenoside-Rd in cephaloridine-induced renal disorder. Nephron. 1999;81:200-7 pubmed
    To determine whether ginsenoside-Rd ameliorates the renal injury induced by cephaloridine, the effect of cephaloridine was investigated in rats given ginsenoside-Rd preceding cephaloridine administration and in control rats given no ..
  4. Kunin C, Atuk N. Excretion of cephaloridine and cephalothin in patients with renal impairment. N Engl J Med. 1966;274:654-6 pubmed
    b>Cephaloridine has been shown to possess certain favorable pharmacologic features while retaining the desirable antimicrobial properties of the parent compound, cephalothin...
  5. Morelli B. Zero-crossing derivative spectrophotometry for the determination of mixtures of cephaloridine and cephalothin in pure and dosage forms. J Pharm Sci. 1988;77:615-21 pubmed
    ..with a zero-crossing technique of measurement, has been used for the quantitation of two-component mixtures of cephaloridine and cephalothin Na, which are cephalosporins with closely overlapping spectral bands...
  6. Coira A, Salvado M, Reig R, Chaves J, Segura C. Beta-lactamase activity in mycobacteria other than M. tuberculosis. J Chemother. 1995;7:106-8 pubmed
    ..chelonae, 10 M. fortuitum, 59 M. gordonae, 55 M. kansasii. The spectrum of hydrolysis of the beta-lactamases was screened using an acidimetric method and the characterization was performed by analytical isoelectric focusing. ..
  7. Valentovic M, Ball J, Anestis D. Contribution of acetone and osmotic-diuresis by streptozotocin-induced diabetes in attenuation of cephaloridine nephrotoxicity. Toxicology. 1992;71:245-55 pubmed
    Previous studies have indicated that cephaloridine nephrotoxicity was reduced in streptozotocin (STZ)-induced diabetic rats...
  8. Bennett J, Brodie J, Benner E, Kirby W. Simplified, accurate method for antibiotic assay of clinical specimens. Appl Microbiol. 1966;14:170-7 pubmed
    ..Adaptation of this method to a number of the commonly used antibiotics is described. With this method, it has been possible to test large numbers of clinical specimens in a minimal time, and with accuracy consistently better than 10%...
  9. Tune B, Hsu C. The renal mitochondrial toxicity of cephalosporins: specificity of the effect on anionic substrate uptake. J Pharmacol Exp Ther. 1990;252:65-9 pubmed
    Previous work in this laboratory has demonstrated a reduction by the nephrotoxic beta-lactam antibiotics cephaloridine, cephaloglycin and imipenem of renal mitochondrial uptake of and respiration with the anionic substrate succinate...

More Information

Publications62

  1. Chiusolo A, Defazio R, Zanetti E, Mongillo M, Mori N, Cristofori P, et al. Kidney injury molecule-1 expression in rat proximal tubule after treatment with segment-specific nephrotoxicants: a tool for early screening of potential kidney toxicity. Toxicol Pathol. 2010;38:338-45 pubmed publisher
    ..HCBD, S(3) segment-specific), potassium dichromate (chromate, S(1)-S(2) segment-specific), and cephaloridine (Cph, S(2) segment-specific)...
  2. Morin J, Marouillat S, Lendormi C, Monteil C. Comparative impact of cephaloridine on glutathione and related enzymes in LLC-PK1, LLC-RK1, and primary cultures of rat and rabbit proximal tubule cells. Cell Biol Toxicol. 1996;12:275-82 pubmed
    ..This paper reports a comparative study of the response to cephaloridine exposure of two established cell lines from pig (LLC-PK1) and rabbit (LLC-RK1) kidneys and primary cultures of ..
  3. Swann J, Acosta D. Failure of gentamicin to elevate cellular malondialdehyde content or increase generation of intracellular reactive oxygen species in primary cultures of renal cortical epithelial cells. Biochem Pharmacol. 1990;40:1523-6 pubmed
    ..We conclude that lipid peroxidation does not play a role in gentamicin cytotoxicity. ..
  4. Sengupta T, Chatterjee A, Das J. Penicillin binding proteins of Vibrio cholerae. Biochem Biophys Res Commun. 1990;171:1175-81 pubmed
    ..The PBP 4 is the most sensitive target for cephaloridine and aztreonam. Cephaloridine also binds to three other high molecular weight PBPs, 1, 2 and 3...
  5. Blahova J, Kralikova K, Krcmery V, Chmelarova E, Torsová V. Two nosocomial strains of Stenotrophomonas maltophilia transferring antibiotic resistance to Proteus mirabilis P-38 recipient strain. J Chemother. 1998;10:22-4 pubmed
    In this report we describe a specific transfer of carbenicillin and cephaloridine resistance determinants from two different strains of Stenotrophomonas maltophilia: No...
  6. Mele G, Gargano G, Greco P, Tartagni M. Antimicrobial prophylaxis for vaginal hysterectomy: comparison of two regimens. Clin Exp Obstet Gynecol. 1988;15:174-7 pubmed
    ..The results, especially in terms of microbiological characteristics of the local population, are then discussed. ..
  7. Reid A, Simpson I, Harper P, Amyes S. Cephaloridine resistance in gram-negative bacteria isolated in Scotland. J Pharm Pharmacol. 1988;40:571-3 pubmed
    The incidence of cephaloridine resistance (minimum inhibitory concentration, MIC greater than 8 mg L-1) in isolates from urinary tract infections was 45.1% in Glasgow, 22.6% in Dundee and 25.9% in Edinburgh...
  8. Suzuki Y, Sudo J. Changes in glutathione peroxidase system and pyridine nucleotide phosphate levels in kidneys of cephaloridine-administered rats. Jpn J Pharmacol. 1989;51:181-9 pubmed
    To elucidate the nephrotoxic mechanisms of cephaloridine (CER), changes in renal contents of glutathione (GSH), glutathione disulfide (GSSG), reduced and oxidized nicotinamide adenine dinucleotide phosphates (NADPH and NADP) and changes ..
  9. Arizono T, Oga M, Sugioka Y. Increased resistance of bacteria after adherence to polymethyl methacrylate. An in vitro study. Acta Orthop Scand. 1992;63:661-4 pubmed
    ..5 mg per mL of Cephaloridine)...
  10. Zawadzke L, Smith T, Herzberg O. An engineered Staphylococcus aureus PC1 beta-lactamase that hydrolyses third-generation cephalosporins. Protein Eng. 1995;8:1275-85 pubmed
    ..aureus beta-lactamase structure, widening the active site cleft and providing space to accommodate the bulky side-chains of the third-generation cephalosporins. ..
  11. Cruz R, Gumbleton M, Nicholls P. In vitro assessment of cephaloridine nephrotoxicity: comparison of renal cortical slice and renal tubule fragment techniques. J Pharmacol Methods. 1988;19:185-92 pubmed
    ..c. dose of either cephaloridine (100 mg/kg) or normal saline (1 ml/kg) 48 h previously...
  12. Sausen P, Elfarra A, Cooley A. Methimazole protection of rats against chemically induced kidney damage in vivo. J Pharmacol Exp Ther. 1992;260:393-401 pubmed
    Because methimazole has antioxidant properties, the effects of methimazole treatment on cephaloridine, S-(1,2-dichlorovinyl)-L-cysteine (DCVC), 2-bromohydroquinone (2-BHQ) and cis-diaminedichloroplatinum (II) (cisplatin)-induced ..
  13. Laska D, Williams P, White S, Thompson C, Hoover D. In vitro correlation of ultrastructural morphology and creatine phosphokinase release in L6 skeletal muscle cells after exposure to parenteral antibiotics. In Vitro Cell Dev Biol. 1990;26:393-8 pubmed
    ..the parenteral antibiotics amphotericin B (AMP), tetracycline-HCl (TET), erythromycin lactobionate (ERY), and cephaloridine (CEP) were characterized by transmission and scanning electron microscopy and compared to cellular release of ..
  14. Drawz S, Bethel C, Doppalapudi V, Sheri A, Pagadala S, Hujer A, et al. Penicillin sulfone inhibitors of class D beta-lactamases. Antimicrob Agents Chemother. 2010;54:1414-24 pubmed publisher
    ..By exploiting conserved structural and mechanistic features, JDB/LN-1-255 is a promising lead compound in the quest for effective inhibitors of OXA-type beta-lactamases. ..
  15. Mukhopadhyay S, Chakrabarti P. Altered permeability and beta-lactam resistance in a mutant of Mycobacterium smegmatis. Antimicrob Agents Chemother. 1997;41:1721-4 pubmed
    ..Mutant M13 was between 7- and 78-fold more resistant than the wild type to cephaloridine, cefoxitin, cefazolin, cefamandole, and cephalothin...
  16. Olivier M, Dutertre Catella H, Thevenin M, Martin C, Warnet J, Claude J. Increased reduced glutathione and glutathione S-transferase activity in chronic cephaloridine nephrotoxicity studies in the rat. Drug Chem Toxicol. 1990;13:209-19 pubmed
    The effect of repeated cephaloridine treatment on renal glutathione and related enzymes has been investigated in young adult male and female Sprague-Dawley rats...
  17. Stahl C, Kubetzko S, Kaps I, Seeber S, Engelhardt H, Niederweis M. MspA provides the main hydrophilic pathway through the cell wall of Mycobacterium smegmatis. Mol Microbiol. 2001;40:451-64 pubmed
    ..Deletion of mspA reduced the cell wall permeability towards cephaloridine and glucose nine- and fourfold respectively...
  18. Fry M, Ngaha E, Plummer D. The protective effects of cephaloridine on rat kidney lysosomes in vitro. Biochem Soc Trans. 1975;3:736-8 pubmed
  19. Muis N, Kamps W, Dankert J. Prevention of infection in children with acute leukaemia. No major difference between total and selective bowel decontamination. Support Care Cancer. 1996;4:200-6 pubmed
    ..TD consisted of colistin sulphate, neomycin, cephaloridine and amphotericin B orally as well as Orabase and sterilized food, while the patients were nursed in a single ..
  20. Hayashi T, Watanabe Y, Kumano K, Kitayama R, Yasuda T, Saikawa I, et al. Protective effect of piperacillin against nephrotoxicity of cephaloridine and gentamicin in animals. Antimicrob Agents Chemother. 1988;32:912-8 pubmed
    The protective effect of piperacillin against the nephrotoxicity of cephaloridine and gentamicin was examined in experimental animals...
  21. Tune B, Hsu C, Fravert D. Mechanisms of the bacterial endotoxin-cephaloridine toxic synergy and the protective effects of saline infusion in the rabbit kidney. J Pharmacol Exp Ther. 1988;244:520-5 pubmed
    ..studied: 1) the effects on mean arterial blood pressure and the clearances of inulin, p-aminohippurate and cephaloridine (Cld) of a 12%-lethal dose of Escherichia coli 0111-B4 LPS (0.05 mg/kg b.wt.i.v...
  22. Tsang W, Ahmed N, Page M. The aminolysis of N-aroyl beta-lactams occurs by a concerted mechanism. Org Biomol Chem. 2007;5:485-93 pubmed
    ..The sensitivity of the Brønsted betanuc and betalg values to the nucleofugality of the amide leaving group and the nucleophilicity of the amine nucleophiles, respectively, indicate coupled bond formation and bond fission processes. ..
  23. Browning M. Effect of verapamil on cephaloridine nephrotoxicity in the rabbit. Toxicol Appl Pharmacol. 1990;103:383-8 pubmed
    b>Cephaloridine produces proximal tubular necrosis in the rabbit kidney. Calcium channel blockers have ameliorated tissue injury due to toxic and ischemic insults...
  24. Faouzi M, Dine T, Luyckx M, Gressier B, Brunet C, Goudaliez F, et al. Stability and compatibility studies of cefaloridine, cefuroxime and ceftazidime with PVC infusion bags. Pharmazie. 1994;49:425-7 pubmed
    ..The results show the stability of drugs during 24 h at room temperature and 7 d storage at +4 degrees C to be satisfactory, irrespective of the infusion solution (5% glucose or 0.9% NaCl). ..
  25. Kohda Y, Gemba M. Cephaloridine induces translocation of protein kinase C delta into mitochondria and enhances mitochondrial generation of free radicals in the kidney cortex of rats causing renal dysfunction. J Pharmacol Sci. 2005;98:49-57 pubmed
    ..the enhancement of free radical generation in mitochondria isolated from the kidney cortex of rats exposed to cephaloridine (CER) is probably mediated by the activation of protein kinase C (PKC)...
  26. Sanchez L, Puig M, Fusté C, Loren J, Vinas M. Outer membrane permeability of non-typable Haemophilus influenzae. J Antimicrob Chemother. 1996;37:341-4 pubmed
    The permeability to cephaloridine was studied in five Haemophilus influenzae strains (four non-typable and one type b) using the Zimmermann and Rosselet method. The beta-lactamase activity was due to a plasmid-encoded TEM-1 enzyme...
  27. Hirouchi Y, Naganuma H, Kawahara Y, Okada R, Kamiya A, Inui K, et al. Protective effect of N-acyl amino acids (NAAs) on cephaloridine (CER) nephrotoxicity in rabbits. Jpn J Pharmacol. 1993;63:487-93 pubmed
    The protective effect of N-acyl amino acids (NAAs) against cephaloridine (CER)-induced nephrotoxicity was studied in rabbits. A large single intravenous dose of CER (more than 100 mg/kg) induced severe proximal tubular necrosis...
  28. Nakamura K, Ito K, Kato Y, Sugaya T, Kubo Y, Tsuji A. L-type fatty acid binding protein transgenic mouse as a novel tool to explore cytotoxicity to renal proximal tubules. Drug Metab Pharmacokinet. 2008;23:271-8 pubmed
    ..of human L-FABP transgenic (Tg) mice as a tool to explore nephrotoxicity, employing two model drugs, cephaloridine and cisplatin, which are taken up by renal tubules via organic anion and cation transporters, respectively...
  29. Dela Vega A, Delcour A. Polyamines decrease Escherichia coli outer membrane permeability. J Bacteriol. 1996;178:3715-21 pubmed
    ..In both cases, inhibition was observed. Measurements of the rate of permeation of cephaloridine and of chemotaxis in swarm plates and capillary assays were used to determine the concentration dependence of ..
  30. Blahova J, Kralikova K, Krcmery V, Schafer V, Torsová V. Transferable resistance to specific antibiotics in nosocomial strains of Pseudomonas aeruginosa from two teaching hospitals. J Chemother. 1996;8:420-4 pubmed
    We describe the transfer of resistance to kanamycin, carbenicillin and cephaloridine to a recipient strain of Escherichia coli K-12 No. 3110 from three strains of Pseudomonas aeruginosa out of 146 strains tested in 1995. The P...
  31. Guitton J, Conjard A, Eid A, Martin M, Boghossian M, Delage H, et al. Identification of novel targets of cephaloridine in rabbit renal proximal tubules synthesizing glutamine from alanine. Arch Toxicol. 2005;79:587-94 pubmed
    b>Cephaloridine, which accumulates in the renal proximal tubule, is a model compound used for studying the toxicity of antibiotics towards this nephron segment...
  32. Kramer W, Cojocel C, Mayer D. Specific alterations of rat renal microsomal proteins induced by cephaloridine. Biochem Pharmacol. 1988;37:4135-40 pubmed
    In order to elucidate the molecular mechanisms of cephaloridine (CPH) nephrotoxicity, the effect of cephaloridine treatment on the protein composition of different subcellular fractions from rat kidney cortex was investigated...
  33. Chaudhary R, Srivastava A. Disposition and dosage regimen of cephaloridine in calves. Vet Res Commun. 1989;13:325-9 pubmed
    The disposition and dosage regimen of cephaloridine were investigated in healthy calves following a single intramuscular administration of 10 mg/kg...
  34. Shimmin L, Vanderwel D, Harkness R, Currie B, Galloway C, Ishiguro E. Temperature-sensitive beta-lactam-tolerant mutants of Escherichia coli. J Gen Microbiol. 1984;130:1315-23 pubmed
    ..The mutations in five isolates were localized to the 56 to 61 min region of the E. coli linkage map and to the 44 to 51 min region in the case of two other isolates. ..
  35. Nagashima K, Kusaka H, Sato K, Karasawa A. Effects of KW-3902, a novel adenosine A1-receptor antagonist, on cephaloridine-induced acute renal failure in rats. Jpn J Pharmacol. 1994;64:9-17 pubmed
    ..8-(noradamantan-3-yl)-1,3-dipropylxanthine), a selective and potent adenosine A1-receptor antagonist, against cephaloridine (CER)-induced acute renal failure (ARF) in rats...
  36. Tune B, Hsu C. Toxicity of cephalosporins to fatty acid metabolism in rabbit renal cortical mitochondria. Biochem Pharmacol. 1995;49:727-34 pubmed
    Cephaloglycin (Cgl) and cephaloridine (Cld) are acutely toxic to the proximal renal tubule, in part because of their cellular uptake by a contraluminal anionic secretory carrier and in part through their intracellular attack on the ..
  37. Goldstein R, Smith P, Tarloff J, Contardi L, Rush G, Hook J. Biochemical mechanisms of cephaloridine nephrotoxicity. Life Sci. 1988;42:1809-16 pubmed
    Large doses of the cephalosporin antibiotic, cephaloridine, produce acute proximal tubular necrosis in humans and in laboratory animals...
  38. Inage F, Kato M, Yoshida M, Akahane K, Takayama S. Lack of nephrotoxic effects of the new quinolone antibacterial agent levofloxacin in rabbits. Arzneimittelforschung. 1992;43:395-7 pubmed
    ..Although reduced body weight gain was observed in the 120 mg/kg, DR-3355 induced no change in function and morphology of the kidneys at both doses. ..
  39. Valentovic M, Jeffrey W, Ball J, Bailly D, Morenas M, Kinder J. Comparative studies of in vitro renal cephaloridine toxicity between normoglycemic and diabetic rats. J Appl Toxicol. 1992;12:19-24 pubmed
    This study investigated if the attenuation in cephaloridine toxicity associated with streptozotocin (STZ)-induced diabetes can be attributed to a direct cellular effect...
  40. Snyder D, McIntosh T. The lipopolysaccharide barrier: correlation of antibiotic susceptibility with antibiotic permeability and fluorescent probe binding kinetics. Biochemistry. 2000;39:11777-87 pubmed
    ..Therefore, we argue that the barrier provided by LPS is primarily due to its tight hydrocarbon chain packing (Snyder et al., (1999) Biochemistry 38, 10758-10767) rather than to its polysaccharide headgroup. ..
  41. Furuno T, Kanno T, Arita K, Asami M, Utsumi T, Doi Y, et al. Roles of long chain fatty acids and carnitine in mitochondrial membrane permeability transition. Biochem Pharmacol. 2001;62:1037-46 pubmed
    ..c release of isolated mitochondria. This suppression was inhibited by cephaloridine, an inhibitor of carnitine uptake into mitochondria...
  42. Cojocel C, Thomson M. Protective effect of resveratrol against 6-hydroxydopamine-induced impairment of renal p-aminohippurate transport. Arch Toxicol. 2004;78:525-32 pubmed
    ..Cisplatin and cephaloridine (CPH), known nephrotoxins, were used as positive controls...
  43. Tsai T, Kao H, Chen C. Measurement and pharmacokinetic analysis of unbound cephaloridine in rat blood by on-line microdialysis and microbore liquid chromatography. Biomed Chromatogr. 2001;15:79-82 pubmed
    A technique involving rapid sampling of cephaloridine in rat blood was achieved using a combination of microdialysis and sensitive microbore liquid chromatography...
  44. Hori R, Shimakura M, Aramata Y, Kizawa K, Nozawa I, Takahata M, et al. [Nephrotoxicity of piperacillin combined with furosemide in rats]. Jpn J Antibiot. 2000;53:582-91 pubmed
    ..These changes were comparable to those in rats receiving furosemide alone. The rats receiving cephaloridine (1600 mg/kg) showed elevation of urinary protein, BUN and creatinine concentrations, and showed moderate ..
  45. Suzuki Y, Sudo J. Lipid peroxidation and generations of oxygen radicals induced by cephaloridine in renal cortical microsomes of rats. Jpn J Pharmacol. 1990;52:233-43 pubmed
    To investigate whether oxygen radicals would be generated by cephaloridine (CER) in the renal cortical microsomes obtained from rats and whether the microsomal lipid peroxidation would be promoted by CER, the microsomes were incubated ..
  46. Khamdang S, Takeda M, Babu E, Noshiro R, Onozato M, Tojo A, et al. Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics. Eur J Pharmacol. 2003;465:1-7 pubmed
    ..via organic anion transporters (OATs) and OAT can mediate nephrotoxicity by cephalosporins, particularly by cephaloridine. The purpose of this study was to elucidate the interaction of human-OAT2 and rat-OAT2 with cephalosporin ..
  47. Stratton C, Kernodle D, Eades S, Weeks L. Evaluation of cefotaxime alone and in combination with desacetylcefotaxime against strains of Staphylococcus aureus that produce variants of staphylococcal beta-lactamase. Diagn Microbiol Infect Dis. 1989;12:57-65 pubmed
    ..These observations may explain the previously demonstrated clinical efficacy of CTX used alone for the treatment of serious infections caused by S. aureus. ..
  48. Powell J, Young K. Lysis of Escherichia coli by beta-lactams which bind penicillin-binding proteins 1a and 1b: inhibition by heat shock proteins. J Bacteriol. 1991;173:4021-6 pubmed
    ..At 30 degrees C, expression of HSPs produced cells that were resistant to lysis by cephaloridine and cefsulodin, antibiotics that bind penicillin-binding proteins (PBPs) 1a and 1b...
  49. Suzuki H, Inoue T, Matsushita T, Kobayashi K, Horii I, Hirabayashi Y, et al. In vitro gene expression analysis of nephrotoxic drugs in rat primary renal cortical tubular cells. J Appl Toxicol. 2008;28:237-48 pubmed publisher
    ..Four direct toxicants, cisplatin (CDDP), its less nephrotoxic analogue carboplatin (CBDCA), cephaloridine and gentamicin, were grouped together in a hierarchical clustering...
  50. Tzouvelekis L, Tzelepi E, Mentis A, Vatopoulos A, Tsakris A. Imipenem resistance in Enterobacter aerogenes is associated with derepression of chromosomal cephalosporinases and impaired permeability. FEMS Microbiol Lett. 1992;74:195-9 pubmed
    ..mutants lacked a major 43-kDa outer membrane protein and displayed decreased permeability to cephaloridine. Introduction of a plasmid coding for the regulatory ampD gene abolished beta-lactamase production and ..
  51. Rush G, Heim R, Ponsler G, Engelhardt J. Cephaloridine-induced renal pathological and biochemical changes in female rabbits and isolated proximal tubules in suspension. Toxicol Pathol. 1992;20:155-68 pubmed
    b>Cephaloridine (Cld) is a nephrotoxic cephalosporin antibiotic. The intracellular biochemical changes that occur leading to Cld-induced nephrotoxicity may involve lipid peroxidation and/or mitochondrial injury...
  52. Yamada T. [Studies on the mechanisms of renal damages induced by nephrotoxic compounds]. Nihon Hoigaku Zasshi. 1995;49:447-57 pubmed
    ..renal damage induced by six nephrotoxic compounds: mercuric chloride (MC), glycerol (GL), maleic acid (MA), cephaloridine (CER), gentamicin (GM) and cisplatin (CDDP) in rats...
  53. Tune B. Effects of L-carnitine on the renal tubular transport of cephaloridine. Biochem Pharmacol. 1995;50:562-4 pubmed
    It has been demonstrated recently that cephaloridine (Cld) inhibits the tubular reabsorption of filtered carnitine (Carn) in the rabbit kidney...