ceftriaxone

Summary

Summary: A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.

Top Publications

  1. Shimuta K, Unemo M, Nakayama S, Morita Ishihara T, Dorin M, Kawahata T, et al. Antimicrobial resistance and molecular typing of Neisseria gonorrhoeae isolates in Kyoto and Osaka, Japan, 2010 to 2012: intensified surveillance after identification of the first strain (H041) with high-level ceftriaxone resistance. Antimicrob Agents Chemother. 2013;57:5225-32 pubmed publisher
    In 2009, the first high-level ceftriaxone-resistant Neisseria gonorrhoeae strain (H041) was isolated in Kyoto, Japan...
  2. Wu C, Wang J, Lee C, Wu K, Tai W, Lu S, et al. The outcome of prophylactic intravenous cefazolin and ceftriaxone in cirrhotic patients at different clinical stages of disease after endoscopic interventions for acute variceal hemorrhage. PLoS ONE. 2013;8:e61666 pubmed publisher
    Antibiotic prophylaxis with norfloxacin, intravenous ciprofloxacin, or ceftriaxone has been recommended for cirrhotic patients with gastrointestinal hemorrhage but little is known about intravenous cefazolin...
  3. Unemo M, Golparian D, Nicholas R, Ohnishi M, Gallay A, Sednaoui P. High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure. Antimicrob Agents Chemother. 2012;56:1273-80 pubmed publisher
    ..the first Neisseria gonorrhoeae strain (H041) highly resistant to the expanded-spectrum cephalosporins (ESCs) ceftriaxone and cefixime, which are the last remaining options for first-line gonorrhea treatment, was isolated in Japan...
  4. Martin I, Sawatzky P, Allen V, Hoang L, Lefebvre B, Mina N, et al. Emergence and characterization of Neisseria gonorrhoeae isolates with decreased susceptibilities to ceftriaxone and cefixime in Canada: 2001-2010. Sex Transm Dis. 2012;39:316-23 pubmed publisher
    ..gonorrhoeae isolates, and those displaying elevated MICs to cefixime (MIC = 0.25 ?g/mL and 0.5 ?g/mL) and ceftriaxone (MIC = 0.125 ?g/mL and 0.25 ?g/mL) were examined using N...
  5. Ohnishi M, Golparian D, Shimuta K, Saika T, Hoshina S, Iwasaku K, et al. Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone. Antimicrob Agents Chemother. 2011;55:3538-45 pubmed publisher
    ..first Neisseria gonorrhoeae strain (H041) that is highly resistant to the extended-spectrum cephalosporin (ESC) ceftriaxone, the last remaining option for empirical first-line treatment, was isolated...
  6. Wagner R, Johnson S, Cerniglia C, Erickson B. Bovine intestinal bacteria inactivate and degrade ceftiofur and ceftriaxone with multiple beta-lactamases. Antimicrob Agents Chemother. 2011;55:4990-8 pubmed publisher
    ..A subset of ceftiofur degraders also degraded the chemically similar drug ceftriaxone. Most of the species of bacteria that degraded ceftiofur belonged to the genera Bacillus and Bacteroides...
  7. Goodrich G, Kabakov A, Hameed M, Dhamne S, Rosenberg P, Rotenberg A. Ceftriaxone treatment after traumatic brain injury restores expression of the glutamate transporter, GLT-1, reduces regional gliosis, and reduces post-traumatic seizures in the rat. J Neurotrauma. 2013;30:1434-41 pubmed publisher
    ..is depressed in the cortex after TBI, and whether GLT-1 expression after TBI is restored after treatment with ceftriaxone, a well-tolerated ?-lactam antibiotic previously shown to enhance GLT-1 expression in noninjured animals...
  8. Nicholson S, Welte T, File T, Strauss R, Michiels B, Kaul P, et al. A randomised, double-blind trial comparing ceftobiprole medocaril with ceftriaxone with or without linezolid for the treatment of patients with community-acquired pneumonia requiring hospitalisation. Int J Antimicrob Agents. 2012;39:240-6 pubmed publisher
    ..severe enough to require hospitalisation were randomised to ceftobiprole or to an expert-recommended course of ceftriaxone ± linezolid (comparator group)...
  9. Goel N, Wattal C, Kaul D, Khanna V. Emergence of ceftriaxone resistant Shigella. Indian J Pediatr. 2013;80:70-1 pubmed publisher
    ..resulting in poor reliability of first line antibiotics like quinolones, co-trimoxazole and ampicillin. Ceftriaxone has been used as a reserved antibiotic for treatment of MDR Shigella spp...

More Information

Publications62

  1. Farina C, Russello G, Chinello P, Pasticci M, Raglio A, Ravasio V, et al. In vitro activity effects of twelve antibiotics alone and in association against twenty-seven Enterococcus faecalis strains isolated from Italian patients with infective endocarditis: high in vitro synergistic effect of the association ceftriaxone-fo. Chemotherapy. 2011;57:426-33 pubmed publisher
    ..A high synergistic effect was obtained with the association ceftriaxone-fosfomycin [fractional inhibitory concentration (FIC)(50) = 0.34, FIC(90) = 0.78]...
  2. Mimura K, Tomimatsu T, Minato K, Jugder O, Kinugasa Taniguchi Y, Kanagawa T, et al. Ceftriaxone preconditioning confers neuroprotection in neonatal rats through glutamate transporter 1 upregulation. Reprod Sci. 2011;18:1193-201 pubmed publisher
    This study investigated the hypothesis that ceftriaxone preconditioning ameliorates brain damage in neonatal animals through glutamate transporter 1 (GLT-1) upregulation...
  3. Cámara J, Serra J, Ayats J, Bastida T, Carnicer Pont D, Andreu A, et al. Molecular characterization of two high-level ceftriaxone-resistant Neisseria gonorrhoeae isolates detected in Catalonia, Spain. J Antimicrob Chemother. 2012;67:1858-60 pubmed publisher
  4. Unemo M, Golparian D, Limnios A, Whiley D, Ohnishi M, Lahra M, et al. In vitro activity of ertapenem versus ceftriaxone against Neisseria gonorrhoeae isolates with highly diverse ceftriaxone MIC values and effects of ceftriaxone resistance determinants: ertapenem for treatment of gonorrhea?. Antimicrob Agents Chemother. 2012;56:3603-9 pubmed publisher
    ..We investigated the in vitro activity of ertapenem, relative to ceftriaxone, against N. gonorrhoeae isolates and the effects of ESC resistance determinants on ertapenem...
  5. Wei J, Pan X, Pei Z, Wang W, Qiu W, Shi Z, et al. The beta-lactam antibiotic, ceftriaxone, provides neuroprotective potential via anti-excitotoxicity and anti-inflammation response in a rat model of traumatic brain injury. J Trauma Acute Care Surg. 2012;73:654-60 pubmed
    The beta-lactam antibiotic, ceftriaxone (CTX), has been reported to induce neuroprotection in animal models of diverse neurologic diseases...
  6. Psomas K, Brun M, Causse A, Atoui N, Reynes J, Le Moing V. Efficacy of ceftriaxone and doxycycline in the treatment of early syphilis. Med Mal Infect. 2012;42:15-9 pubmed publisher
    ..The time to serological response was similar among those treated with benzathine-penicillin (n=52), ceftriaxone (n=49), or doxycycline (n=15)...
  7. Goire N, Ohnishi M, Limnios A, Lahra M, Lambert S, Nimmo G, et al. Enhanced gonococcal antimicrobial surveillance in the era of ceftriaxone resistance: a real-time PCR assay for direct detection of the Neisseria gonorrhoeae H041 strain. J Antimicrob Chemother. 2012;67:902-5 pubmed publisher
    ..In this study we developed a real-time PCR assay for direct detection of the H041 strain...
  8. Lai P, Huang Y, Wu C, Lai C, Wang P, Chiu T. Ceftriaxone attenuates hypoxic-ischemic brain injury in neonatal rats. J Biomed Sci. 2011;18:69 pubmed publisher
    ..Compounds, such as ceftriaxone, that enhance the expression of GLT1 may exert neuroprotective effect in HIE...
  9. Macaluso A, Bernabucci M, Trabucco A, Ciolli L, Troisi F, Baldini R, et al. Analgesic effect of a single preoperative dose of the antibiotic ceftriaxone in humans. J Pain. 2013;14:604-12 pubmed publisher
    Repeated injections of the antibiotic ceftriaxone cause analgesia in rodents by upregulating the glutamate transporter, GLT-1. No evidence is available in humans...
  10. Molyneux E, Nizami S, Saha S, Huu K, Azam M, Bhutta Z, et al. 5 versus 10 days of treatment with ceftriaxone for bacterial meningitis in children: a double-blind randomised equivalence study. Lancet. 2011;377:1837-45 pubmed publisher
    ..We aimed to compare the efficacy of 5 and 10 days of parenteral ceftriaxone for the treatment of bacterial meningitis in children...
  11. Read P, Limnios E, McNulty A, Whiley D, Lahra M. One confirmed and one suspected case of pharyngeal gonorrhoea treatment failure following 500mg ceftriaxone in Sydney, Australia. Sex Health. 2013;10:460-2 pubmed publisher
    ..We report the cases of two homosexual men, both treated for pharyngeal NG with 500mg intramuscular ceftriaxone, in whom a test of cure 1 week after treatment showed persisting infection...
  12. Croisier Bertin D, Piroth L, Charles P, Larribeau A, Biek D, Ge Y, et al. Ceftaroline versus ceftriaxone in a highly penicillin-resistant pneumococcal pneumonia rabbit model using simulated human dosing. Antimicrob Agents Chemother. 2011;55:3557-63 pubmed publisher
    ..This study investigated the in vivo efficacy of a 48-hour simulated human dose regimen of CPT compared with ceftriaxone (CRO) against isolates of S...
  13. Berry J, Shefner J, Conwit R, Schoenfeld D, Keroack M, Felsenstein D, et al. Design and initial results of a multi-phase randomized trial of ceftriaxone in amyotrophic lateral sclerosis. PLoS ONE. 2013;8:e61177 pubmed publisher
    b>Ceftriaxone increases expression of the astrocytic glutamate transporter, EAAT2, which might protect from glutamate-mediated excitotoxicity...
  14. Endt K, Maier L, Käppeli R, Barthel M, Misselwitz B, Kremer M, et al. Peroral ciprofloxacin therapy impairs the generation of a protective immune response in a mouse model for Salmonella enterica serovar Typhimurium diarrhea, while parenteral ceftriaxone therapy does not. Antimicrob Agents Chemother. 2012;56:2295-304 pubmed publisher
    ..os treatment with ciprofloxacin (15 mg/kg of body weight intragastrically 2 times/day, 5 days) or parenteral ceftriaxone (50 mg/kg intraperitoneally, 5 days), two common drugs used in human patients...
  15. Medina Presentado J, Paciel López D, Berro Castiglioni M, Gerez J. Ceftriaxone and ciprofloxacin restriction in an intensive care unit: less incidence of Acinetobacter spp. and improved susceptibility of Pseudomonas aeruginosa. Rev Panam Salud Publica. 2011;30:603-9 pubmed
    To determine whether restricting the use of ceftriaxone and ciprofloxacin could significantly reduce colonization and infection with resistant Gram-negative bacilli (r-GNB)...
  16. Boggs S, Cunnion K, Raafat R. Ceftriaxone-induced hemolysis in a child with Lyme arthritis: a case for antimicrobial stewardship. Pediatrics. 2011;128:e1289-92 pubmed publisher
    ..We report here the case of a young girl treated with intravenous ceftriaxone who subsequently developed drug-induced autoimmune hemolytic anemia and renal failure...
  17. Hu W, Chen H, Zhang R, Huang C, Shen C. The expression levels of outer membrane proteins STM1530 and OmpD, which are influenced by the CpxAR and BaeSR two-component systems, play important roles in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. Antimicrob Agents Chemother. 2011;55:3829-37 pubmed publisher
    ..STM1530, and AcrD protein levels and significant decreases in OmpC and OmpD protein levels are present when the ceftriaxone-resistant Salmonella enterica serovar Typhimurium R200 strain is compared with the ceftriaxone-susceptible ..
  18. McKinnell J, Kunz D, Chamot E, Patel M, Shirley R, Moser S, et al. Association between vancomycin-resistant Enterococci bacteremia and ceftriaxone usage. Infect Control Hosp Epidemiol. 2012;33:718-24 pubmed publisher
    ..Animal investigations suggest that ceftriaxone may be associated with VRE proliferation...
  19. Wieland B, Marcantoni J, Bommarito K, Warren D, Marschall J. A retrospective comparison of ceftriaxone versus oxacillin for osteoarticular infections due to methicillin-susceptible Staphylococcus aureus. Clin Infect Dis. 2012;54:585-90 pubmed publisher
    ..b>Ceftriaxone can be dosed once daily and is less expensive for outpatient therapy than oxacillin...
  20. Carannante A, Prignano G, Cusini M, Matteelli A, Dal Conte I, Ghisetti V, et al. Cefixime and ceftriaxone susceptibility of Neisseria gonorrhoeae in Italy from 2006 to 2010. Clin Microbiol Infect. 2012;18:558-64 pubmed publisher
    ..12 mg/L) and CLSI 2008 (MIC R >0.25 mg/L) criteria. All isolates showed full susceptibility to ceftriaxone, whereas those with a MIC for cefixime ?0.125 mg/L were on the increase from 2008 through 2010...
  21. Davies T, Flamm R, Lynch A. Activity of ceftobiprole against Streptococcus pneumoniae isolates exhibiting high-level resistance to ceftriaxone. Int J Antimicrob Agents. 2012;39:534-8 pubmed publisher
    ..the US Today (TRUST) 2008 surveillance data showed that 6% of Streptococcus pneumoniae were non-susceptible to ceftriaxone [minimum inhibitory concentration (MIC) ? 2 ?g/mL] and that 8% of the ceftriaxone-non-susceptible isolates ..
  22. Yuan L, Yin Y, Dai X, Pearline R, Xiang Z, Unemo M, et al. Resistance to azithromycin of Neisseria gonorrhoeae isolates from 2 cities in China. Sex Transm Dis. 2011;38:764-8 pubmed publisher
    ..Minimum inhibitory concentration (MIC) of azithromycin, tetracycline, ciprofloxacin, spectinomycin and ceftriaxone was determined using the agar dilution method...
  23. Hajdu S, Lassnigg A, Graninger W, Hirschl A, Presterl E. Effects of vancomycin, daptomycin, fosfomycin, tigecycline, and ceftriaxone on Staphylococcus epidermidis biofilms. J Orthop Res. 2009;27:1361-5 pubmed publisher
    ..In the following work, we investigated the effects of vancomycin, daptomycin, fosfomycin, tigecycline, and ceftriaxone on biofilms formed by Staphylococcus epidermidis isolates causative for implant infection and catheter-..
  24. Grandgirard D, Oberson K, Bühlmann A, Gäumann R, Leib S. Attenuation of cerebrospinal fluid inflammation by the nonbacteriolytic antibiotic daptomycin versus that by ceftriaxone in experimental pneumococcal meningitis. Antimicrob Agents Chemother. 2010;54:1323-6 pubmed publisher
    ..assessed in an infant rat pneumococcal meningitis model for the nonbacteriolytic antibiotic daptomycin versus ceftriaxone. Daptomycin led to lower CSF concentrations of interleukin 1beta (IL-1beta), IL-10, IL-18, monocyte ..
  25. Thone Reineke C, Neumann C, Namsolleck P, Schmerbach K, Krikov M, Schefe J, et al. The beta-lactam antibiotic, ceftriaxone, dramatically improves survival, increases glutamate uptake and induces neurotrophins in stroke. J Hypertens. 2008;26:2426-35 pubmed publisher
    b>Ceftriaxone has been reported to reduce neuronal damage in amyotrophic lateral sclerosis and in an in-vitro model of neuronal ischaemia through increased expression and activity of the glutamate transporter, GLT1...
  26. Ahmed E, Mirghani O, Gerais A, Adam I. Ceftriaxone versus ampicillin/cloxacillin as antibiotic prophylaxis in elective caesarean section. East Mediterr Health J. 2004;10:277-88 pubmed
    We carried out a prospective, randomized, controlled clinical trial to evaluate the clinical efficacy of ceftriaxone and ampicillin/cloxacillin prophylaxis in decreasing the frequency of post-caesarean section infection-related morbidity...
  27. Yrjänäinen H, Hytönen J, Song X, Oksi J, Hartiala K, Viljanen M. Anti-tumor necrosis factor-alpha treatment activates Borrelia burgdorferi spirochetes 4 weeks after ceftriaxone treatment in C3H/He mice. J Infect Dis. 2007;195:1489-96 pubmed
    The effect of anti-tumor necrosis factor (TNF)-alpha treatment in Borrelia burgdorferi-infected and ceftriaxone-treated C3H/He mice was evaluated.
  28. Merrigan M, Sambol S, Johnson S, Gerding D. New approach to the management of Clostridium difficile infection: colonisation with non-toxigenic C. difficile during daily ampicillin or ceftriaxone administration. Int J Antimicrob Agents. 2009;33 Suppl 1:S46-50 pubmed publisher
    ..difficile to colonise hamsters during administration of an antibiotic to which the organisms are resistant - ceftriaxone - and an antibiotic to which they are susceptible - ampicillin - and to determine if non-toxigenic colonisation ..
  29. Dubray C, Ibrahim S, Abdelmutalib M, Guerin P, Dantoine F, Belanger F, et al. Treatment of severe malnutrition with 2-day intramuscular ceftriaxone vs 5-day amoxicillin. Ann Trop Paediatr. 2008;28:13-22 pubmed publisher
    ..unblinded, superiority-controlled trial was conducted, comparing once daily intramuscular injection with ceftriaxone for 2 days with oral amoxicillin twice daily for 5 days in children aged 6-59 months with SAM...
  30. Rothstein J, Patel S, Regan M, Haenggeli C, Huang Y, Bergles D, et al. Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature. 2005;433:73-7 pubmed
    ..When delivered to animals, the beta-lactam ceftriaxone increased both brain expression of GLT1 and its biochemical and functional activity...
  31. Whiley D, Goire N, Lambert S, Ray S, Limnios E, Nissen M, et al. Reduced susceptibility to ceftriaxone in Neisseria gonorrhoeae is associated with mutations G542S, P551S and P551L in the gonococcal penicillin-binding protein 2. J Antimicrob Chemother. 2010;65:1615-8 pubmed publisher
    ..In this study, we examined an association between reduced susceptibility to ceftriaxone and additional mutations in gonococcal PBP2. N...
  32. Fernandez J, Ruiz del Arbol L, Gomez C, Durandez R, Serradilla R, Guarner C, et al. Norfloxacin vs ceftriaxone in the prophylaxis of infections in patients with advanced cirrhosis and hemorrhage. Gastroenterology. 2006;131:1049-56; quiz 1285 pubmed
    ..This randomized controlled trial was aimed to compare oral norfloxacin vs intravenous ceftriaxone in the prophylaxis of bacterial infection in cirrhotic patients with gastrointestinal bleeding...
  33. Walter T, Lebouche B, Miailhes P, Cotte L, Roure C, Schlienger I, et al. Symptomatic relapse of neurologic syphilis after benzathine penicillin G therapy for primary or secondary syphilis in HIV-infected patients. Clin Infect Dis. 2006;43:787-90 pubmed
    ..Because HIV infection may alter the natural history and response of neurologic syphilis to treatment, scrupulous follow-up and repeated cycles of therapy are warranted...
  34. File T, Low D, Eckburg P, Talbot G, Friedland H, Lee J, et al. FOCUS 1: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia. J Antimicrob Chemother. 2011;66 Suppl 3:iii19-32 pubmed publisher
    ..CI) ? -10%] in clinical cure rates achieved with ceftaroline fosamil compared with those achieved with ceftriaxone in the clinically evaluable (CE) and modified intent-to-treat efficacy (MITTE) populations...
  35. Anderson R, Steel H, Cockeran R, Von Gottberg A, de Gouveia L, Klugman K, et al. Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitro. J Antimicrob Chemother. 2007;60:1155-8 pubmed
    To compare the effects of subinhibitory concentrations of amoxicillin, ceftriaxone, azithromycin, clarithromycin, erythromycin, telithromycin, clindamycin, ciprofloxacin, moxifloxacin, tobramycin and doxycycline on pneumolysin production ..
  36. Böttcher T, Ren H, Goiny M, Gerber J, Lykkesfeldt J, Kuhnt U, et al. Clindamycin is neuroprotective in experimental Streptococcus pneumoniae meningitis compared with ceftriaxone. J Neurochem. 2004;91:1450-60 pubmed
    In animal models of Streptococcus pneumoniae meningitis, rifampin is neuroprotective in comparison to ceftriaxone. So far it is not clear whether this can be generalized for other protein synthesis-inhibiting antimicrobial agents...
  37. Pereira C, Petrilli A, Carlesse F, Luisi F, da Silva K, de Martino Lee M. Cefepime monotherapy is as effective as ceftriaxone plus amikacin in pediatric patients with cancer and high-risk febrile neutropenia in a randomized comparison. J Microbiol Immunol Infect. 2009;42:141-7 pubmed
    ..The aim of this study was to compare the efficacy and safety of cefepime (CFP) monotherapy with ceftriaxone plus amikacin (CFT+AK) in children and adolescents with febrile neutropenia (FN)...
  38. Huang I, Chiu C, Wang M, Wu C, Hsieh K, Chiou C. Outbreak of dysentery associated with ceftriaxone-resistant Shigella sonnei: First report of plasmid-mediated CMY-2-type AmpC beta-lactamase resistance in S. sonnei. J Clin Microbiol. 2005;43:2608-12 pubmed
    ..report of plasmid-encoded CMY-2-type AmpC beta-lactamase identified among Shigella sonnei isolates resistant to ceftriaxone and obtained after an outbreak of bacillary dysentery in Taiwan...
  39. Gargollo P, Barnewolt C, Diamond D. Pediatric ceftriaxone nephrolithiasis. J Urol. 2005;173:577-8 pubmed
  40. Sun H, Tseng S, Hsueh P, Hung C, Hsieh S, Teng L, et al. Occurrence of ceftriaxone resistance in ciprofloxacin-resistant Salmonella enterica serotype Choleraesuis isolates causing recurrent infection. Clin Infect Dis. 2005;40:208-9 pubmed
  41. Frei C, Jaso T, Mortensen E, Restrepo M, Raut M, Oramasionwu C, et al. Medical resource utilization among community-acquired pneumonia patients initially treated with levofloxacin 750 mg daily versus ceftriaxone 1000 mg plus azithromycin 500 mg daily: a US-based study. Curr Med Res Opin. 2009;25:859-68 pubmed
    ..of intravenous antibiotic therapy (LOIV) for patients who received initial levofloxacin 750 mg daily versus ceftriaxone 1000 mg plus azithromycin 500 mg daily ('combination therapy')...
  42. Kapur G, Valentini R, Mattoo T, Warrier I, Imam A. Ceftriaxone induced hemolysis complicated by acute renal failure. Pediatr Blood Cancer. 2008;50:139-42 pubmed
    ..Of these cases, 20% have been attributed to ceftriaxone. The clinical presentation of ceftriaxone-induced HA is usually abrupt with sudden onset of pallor, tachypnea, ..
  43. Monfort L, Caro V, Devaux Z, Delannoy A, Brisse S, Sednaoui P. First neisseria gonorrhoeae genotyping analysis in france: identification of a strain cluster with reduced susceptibility to Ceftriaxone. J Clin Microbiol. 2009;47:3540-5 pubmed publisher
    ..in many countries, comprised isolates (14/16) resistant to ciprofloxacin and with reduced susceptibility to ceftriaxone. Thus, the surveillance of resistance to antibiotics is a priority in order to adapt treatment and decrease the ..
  44. Frye J, Fedorka Cray P, Jackson C, Rose M. Analysis of Salmonella enterica with reduced susceptibility to the third-generation cephalosporin ceftriaxone isolated from U.S. cattle during 2000-2004. Microb Drug Resist. 2008;14:251-8 pubmed publisher
    ..susceptibility (minimum inhibitory concentration [MIC] >32 microg/ml) to the third-generation cephalosporin ceftriaxone. The majority of these were serotypes Newport (58) and Agona (14), some of which were genetically ..
  45. Biner B, Oner N, Celtik C, Bostancioglu M, Tuncbilek N, Guzel A, et al. Ceftriaxone-associated biliary pseudolithiasis in children. J Clin Ultrasound. 2006;34:217-22 pubmed
    b>Ceftriaxone is known to induce reversible precipitations, known as pseudolithiasis, in the gallbladder and urinary tract. The aim of this study was to investigate the incidence and predisposing factors that contribute to this side effect...
  46. Sánchez E, Such J, Chiva M, Soriano G, Llovet T, Merce J, et al. Development of an experimental model of induced bacterial peritonitis in cirrhotic rats with or without ascites. Am J Gastroenterol. 2007;102:1230-6 pubmed
    ..A subgroup of nonascitic animals received ceftriaxone 4 h after E. coli inoculation. Mortality of rats was evaluated 24 h after bacterial inoculation...
  47. Larsson C, Lundqvist J, Bergstrom S. Residual brain infection in murine relapsing fever borreliosis can be successfully treated with ceftriaxone. Microb Pathog. 2008;44:262-4 pubmed
    ..harboring residual Borrelia duttonii brain infection with the bacteriocidal, cell wall inhibiting antibiotic ceftriaxone, bacteria were cleared from the brain...
  48. Hota S, Barhwal K, Ray K, Singh S, Ilavazhagan G. Ceftriaxone rescues hippocampal neurons from excitotoxicity and enhances memory retrieval in chronic hypobaric hypoxia. Neurobiol Learn Mem. 2008;89:522-32 pubmed publisher
    ..Considering previous reports on upregulation of the expression of Glial Glutamate Transporter on ceftriaxone administration, the therapeutic potential of ceftriaxone in ameliorating hypobaric hypoxia induced memory ..
  49. Anderson R, Steel H, Cockeran R, Smith A, Von Gottberg A, de Gouveia L, et al. Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae. J Antimicrob Chemother. 2007;59:224-9 pubmed
    To investigate the effects of clarithromycin (0.01-0.5 mg/L) alone or in combination with ceftriaxone (0.1 and 0...
  50. Shen Y, Hwang K, Niu C. Complicated parapneumonic effusion and empyema in children. J Microbiol Immunol Infect. 2006;39:483-8 pubmed
  51. Wallace K, Lopez J, Shaffery J, Wells A, Paul I, Bennett W. Interleukin-10/Ceftriaxone prevents E. coli-induced delays in sensorimotor task learning and spatial memory in neonatal and adult Sprague-Dawley rats. Brain Res Bull. 2010;81:141-8 pubmed publisher
    ..Both interleukin-10 (IL-10) and Ceftriaxone have been shown to decrease immune system activation and increase memory capacity, respectively...
  52. Bellesi M, Melone M, Gubbini A, Battistacci S, Conti F. GLT-1 upregulation impairs prepulse inhibition of the startle reflex in adult rats. Glia. 2009;57:703-13 pubmed publisher
    ..To do this, we studied PPI in rats treated with ceftriaxone (200 mg/kg/day for 8 days), an antibiotic that selectively enhances GLT-1 expression and activity...
  53. Schuettpelz L, Behrens D, Goldsmith M, Druley T. Severe ceftriaxone-induced hemolysis complicated by diffuse cerebral ischemia in a child with sickle cell disease. J Pediatr Hematol Oncol. 2009;31:870-2 pubmed publisher
    b>Ceftriaxone-induced hemolytic anemia is a rare and often fatal phenomenon. We report here the case of a 6-year-old female with sickle cell disease who survived a brisk and profound hemolytic reaction, resulting in hemoglobin of 0...