cefotaxime

Summary

Summary: Semisynthetic broad-spectrum cephalosporin.

Top Publications

  1. Rossolini G, D Andrea M, Mugnaioli C. The spread of CTX-M-type extended-spectrum beta-lactamases. Clin Microbiol Infect. 2008;14 Suppl 1:33-41 pubmed
    ..CTX-M-type ESBLs exhibit powerful activity against cefotaxime and ceftriaxone but generally not against ceftazidime, which has important implications for laboratory detection...
  2. Madec J, Lazizzera C, Châtre P, Meunier D, Martin S, Lepage G, et al. Prevalence of fecal carriage of acquired expanded-spectrum cephalosporin resistance in Enterobacteriaceae strains from cattle in France. J Clin Microbiol. 2008;46:1566-7 pubmed publisher
  3. Sharma R, Choudhary S, Kishore N. Insights into the binding of the drugs diclofenac sodium and cefotaxime sodium to serum albumin: calorimetry and spectroscopy. Eur J Pharm Sci. 2012;46:435-45 pubmed publisher
    ..Binding of a non-steroidal anti-inflammatory drug, diclofenac sodium (DCF) and an antibiotic drug, cefotaxime sodium (CFT) belonging to the family of cephalosporins with bovine serum albumin (BSA) has been examined using a ..
  4. Veldman K, van Tulden P, Kant A, Testerink J, Mevius D. Characteristics of cefotaxime-resistant Escherichia coli from wild birds in the Netherlands. Appl Environ Microbiol. 2013;79:7556-61 pubmed publisher
    ..Cloacal swabs from carcasses of Dutch wild birds obtained in 2010 and 2011 were selectively cultured on media with cefotaxime to screen for the presence of extended-spectrum ?-lactamase (ESBL)/AmpC-producing Escherichia coli...
  5. Jean S, Lee Y, Guo S, Hsueh P. Recurrent infections caused by cefotaxime- and ciprofloxacin-resistant Salmonella enterica serotype choleraesuis treated successfully with imipenem. J Infect. 2005;51:e163-5 pubmed
    ..case of recurrent infection (infective spondilitis, psoas abscess, and bacteraemia) caused by a single strain of cefotaxime- and ciprofloxacin-resistant and bla(CMY-2)-containing Salmonella enterica serotype choleraesuis during a 4-..
  6. Shih H, Lee H, Lee N, Chang C, Wu C, Wang L, et al. Serratia marcescens bacteremia at a medical center in southern Taiwan: high prevalence of cefotaxime resistance. J Microbiol Immunol Infect. 2005;38:350-7 pubmed
    ..By disk susceptibility test, 72 isolates were resistant to cefotaxime (92%) but susceptible to ceftazidime (99%). All isolates were susceptible to meropenem...
  7. Dahyot Fizelier C, Frasca D, Gregoire N, Adier C, Mimoz O, Debaene B, et al. Microdialysis study of cefotaxime cerebral distribution in patients with acute brain injury. Antimicrob Agents Chemother. 2013;57:2738-42 pubmed publisher
    ..The aim of this study was to describe brain distribution of cefotaxime (2 g/8 h) by microdialysis in patients with acute brain injury who were treated for a lung infection...
  8. Fani F, Brotherton M, Leprohon P, Ouellette M. Genomic analysis and reconstruction of cefotaxime resistance in Streptococcus pneumoniae. J Antimicrob Chemother. 2013;68:1718-27 pubmed publisher
    To identify non-penicillin-binding protein (PBP) mutations contributing to resistance to the third-generation cephalosporin cefotaxime in Streptococcus pneumoniae at the genome-wide scale.
  9. Goldwater P. Cefotaxime and ceftriaxone cerebrospinal fluid levels during treatment of bacterial meningitis in children. Int J Antimicrob Agents. 2005;26:408-11 pubmed
    b>Cefotaxime (CTX) and ceftriaxone (CRO) were compared for cerebrospinal fluid (CSF) penetration and antimicrobial efficacy in cases of bacterial meningitis in children...

More Information

Publications62

  1. Novais A, Canton R, Coque T, Moya A, Baquero F, Galan J. Mutational events in cefotaximase extended-spectrum beta-lactamases of the CTX-M-1 cluster involved in ceftazidime resistance. Antimicrob Agents Chemother. 2008;52:2377-82 pubmed publisher
    CTX-M beta-lactamases, which show a high cefotaxime hydrolytic activity, constitute the most prevalent extended-spectrum beta-lactamase (ESBL) type found among clinical isolates...
  2. Bershtein S, Tawfik D. Ohno's model revisited: measuring the frequency of potentially adaptive mutations under various mutational drifts. Mol Biol Evol. 2008;25:2311-8 pubmed publisher
    ..in the population relieved from selection (Ohno's model) afforded only a narrow window of adaptation to cefotaxime (neofunctionalization)...
  3. Chiang S, Tang H, Chang P, Cheng K, Ko W, Chen C, et al. Synergistic antimicrobial effect of cefotaxime and minocycline on proinflammatory cytokine levels in a murine model of Vibrio vulnificus infection. J Microbiol Immunol Infect. 2007;40:123-33 pubmed
    ..This study aimed to evaluate the antimicrobial effect of cefotaxime and minocycline on proinflammatory cytokine levels in a murine model of V. vulnificus infection.
  4. Lepercq J, Treluyer J, Auger C, Raymond J, Rey E, Schmitz T, et al. Evaluation of cefotaxime and desacetylcefotaxime concentrations in cord blood after intrapartum prophylaxis with cefotaxime. Antimicrob Agents Chemother. 2009;53:2342-5 pubmed publisher
    ..coli. Our aim was to investigate whether a standardized dosage regimen of intrapartum cefotaxime could provide concentrations in the cord blood greater than the cefotaxime MIC(90) for E. coli...
  5. Yong D, Toleman M, Giske C, Cho H, Sundman K, Lee K, et al. Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother. 2009;53:5046-54 pubmed publisher
    ..Compared to VIM-2, NDM-1 displays tighter binding to most cephalosporins, in particular, cefuroxime, cefotaxime, and cephalothin (cefalotin), and also to the penicillins...
  6. Kim D, Neupane G, Jang S, Kim S, Lee B. In vitro efficacy of the combination of ciprofloxacin and cefotaxime against nalidixic acid-resistant Salmonella enterica serotype Typhi. Int J Antimicrob Agents. 2010;36:155-8 pubmed publisher
    ..Typhi (NASST) ATCC 9992 with ciprofloxacin, cefotaxime and azithromycin in various combinations. The combination of ciprofloxacin (0.012-0...
  7. Schneider I, Queenan A, Markovska R, Markova B, Keuleyan E, Bauernfeind A. New variant of CTX-M-type extended-spectrum beta-lactamases, CTX-M-71, with a Gly238Cys substitution in a Klebsiella pneumoniae isolate from Bulgaria. Antimicrob Agents Chemother. 2009;53:4518-21 pubmed publisher
    ..This exchange decreased the hydrolytic activity of the beta-lactamase for cefotaxime, ceftazidime, and cefepime.
  8. Kim S, Hu J, Gautom R, Kim J, Lee B, Boyle D. CTX-M extended-spectrum beta-lactamases, Washington State. Emerg Infect Dis. 2007;13:513-4 pubmed
  9. Weinreich D, Delaney N, DePristo M, Hartl D. Darwinian evolution can follow only very few mutational paths to fitter proteins. Science. 2006;312:111-4 pubmed
    ..This implies that the protein tape of life may be largely reproducible and even predictable. ..
  10. Heymans R, Bruisten S, Golparian D, Unemo M, de Vries H, van Dam A. Clonally related Neisseria gonorrhoeae isolates with decreased susceptibility to the extended-spectrum cephalosporin cefotaxime in Amsterdam, the Netherlands. Antimicrob Agents Chemother. 2012;56:1516-22 pubmed publisher
    ..gonorrhoeae isolates were identified with decreased susceptibility to the extended-spectrum cephalosporin (ESC) cefotaxime among visitors of the Amsterdam sexually transmitted infections (STI) clinic, the Netherlands...
  11. Schenk M, Szendro I, Krug J, de Visser J. Quantifying the adaptive potential of an antibiotic resistance enzyme. PLoS Genet. 2012;8:e1002783 pubmed publisher
    ..Here, we study the distribution of mutation effects on cefotaxime (Ctx) resistance and fitness of 48 unique beneficial mutations in the bacterial enzyme TEM-1 ?-lactamase, which ..
  12. Nigam P, Mohan S, Kundu S, Prakash R. Trace analysis of cefotaxime at carbon paste electrode modified with novel Schiff base Zn(II) complex. Talanta. 2009;77:1426-31 pubmed publisher
    b>Cefotaxime a third generation cephalosporin drug estimation in nanomolar concentration range is demonstrated for the first time in aqueous and human blood samples using novel Schiff base octahedral Zn(II) complex...
  13. Garcia Cobos S, Arroyo M, Perez Vazquez M, Aracil B, Lara N, Oteo J, et al. Isolates of ?-lactamase-negative ampicillin-resistant Haemophilus influenzae causing invasive infections in Spain remain susceptible to cefotaxime and imipenem. J Antimicrob Chemother. 2014;69:111-6 pubmed publisher
    ..Our main goal was to determine whether invasive H. influenzae remains susceptible to ?-lactam antibiotics indicated in the treatment of invasive infections...
  14. Liebana E, Batchelor M, Hopkins K, Clifton Hadley F, Teale C, Foster A, et al. Longitudinal farm study of extended-spectrum beta-lactamase-mediated resistance. J Clin Microbiol. 2006;44:1630-4 pubmed
    ..Escherichia coli isolates with resistance to a wide range of beta-lactams (including amoxicillin-clavulanate and cefotaxime) were isolated from scouring calves...
  15. Li J, Ma Y, Hu C, Jin S, Zhang Q, Ding H, et al. Dissemination of cefotaxime-M-producing Escherichia coli isolates in poultry farms, but not swine farms, in China. Foodborne Pathog Dis. 2010;7:1387-92 pubmed publisher
    ..Of 56 ESBL-producing isolates, 54 isolates contained cefotaxime (CTX)-M type ?-lactamases, including bla(CTX-M-14) (n = 24), bla(CTX-M-65) (n = 13), bla(CTX-M-55) (n = 10), bla(..
  16. Oteo J, Navarro C, Cercenado E, Delgado Iribarren A, Wilhelmi I, Orden B, et al. Spread of Escherichia coli strains with high-level cefotaxime and ceftazidime resistance between the community, long-term care facilities, and hospital institutions. J Clin Microbiol. 2006;44:2359-66 pubmed
    A total of 151 Escherichia coli strains resistant to cefotaxime and ceftazidime were isolated during a prospective surveillance study...
  17. Sung W, Lee D. The combination effect of Korean red ginseng saponins with kanamycin and cefotaxime against methicillin-resistant Staphylococcus aureus. Biol Pharm Bull. 2008;31:1614-7 pubmed
    ..To estimate the general combination effects of ginsenosides and commercial antibiotics, such as kanamycin and cefotaxime, on antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) strains that were ..
  18. Fenoll A, Gimenez M, Robledo O, Aguilar L, Tarrago D, Granizo J, et al. Influence of penicillin/amoxicillin non-susceptibility on the activity of third-generation cephalosporins against Streptococcus pneumoniae. Eur J Clin Microbiol Infect Dis. 2008;27:75-80 pubmed
    ..Penicillin-susceptible strains were susceptible to amoxicillin, cefotaxime and ceftriaxone, 99.8% to cefpodoxime and 99.5% to cefdinir, and were inhibited by 0...
  19. Soriano F, Cafini F, Aguilar L, Tarrago D, Alou L, Gimenez M, et al. Breakthrough in penicillin resistance? Streptococcus pneumoniae isolates with penicillin/cefotaxime MICs of 16 mg/L and their genotypic and geographical relatedness. J Antimicrob Chemother. 2008;62:1234-40 pubmed publisher
    ..was determined in triplicate by microdilution (CLSI guidelines), and additionally, MICs of penicillin, cefotaxime and amoxicillin were confirmed in triplicate by agar dilution...
  20. Salverda M, Dellus E, Gorter F, Debets A, van der Oost J, Hoekstra R, et al. Initial mutations direct alternative pathways of protein evolution. PLoS Genet. 2011;7:e1001321 pubmed publisher
    ..the diversity of adaptive pathways among replicate lines during evolution for resistance to a novel antibiotic (cefotaxime)...
  21. Molina Quiroz R, Muñoz Villagrán C, de la Torre E, Tantaleán J, Vásquez C, Pérez Donoso J. Enhancing the antibiotic antibacterial effect by sub lethal tellurite concentrations: tellurite and cefotaxime act synergistically in Escherichia coli. PLoS ONE. 2012;7:e35452 pubmed publisher
    ..and clinical, uropathogenic Escherichia coli, especially with antibiotics disturbing the cell wall (ampicillin, cefotaxime) or protein synthesis (tetracycline, chloramphenicol, gentamicin)...
  22. Cheung T, Chu Y, Tsang G, Ngan J, Hui I, Kam K. Emergence of CTX-M-type beta-lactam resistance in Shigella spp. in Hong Kong. Int J Antimicrob Agents. 2005;25:350-2 pubmed
  23. Mory F, Fougnot S, Rabaud C, Schuhmacher H, Lozniewski A. In vitro activities of cefotaxime, vancomycin, quinupristin/dalfopristin, linezolid and other antibiotics alone and in combination against Propionibacterium acnes isolates from central nervous system infections. J Antimicrob Chemother. 2005;55:265-8 pubmed
    ..vancomycin was the most effective drug and exhibited bactericidal activity after 24 h at 1x and 2 x MIC, whereas cefotaxime and ciprofloxacin were bactericidal after 48 h at 2 x MIC...
  24. Shimamura T, Ibuka A, Fushinobu S, Wakagi T, Ishiguro M, Ishii Y, et al. Acyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillin. J Biol Chem. 2002;277:46601-8 pubmed
    ..We present the acyl-intermediate structures of Toho-1 in complex with cefotaxime (expanded-spectrum cephalosporin), cephalothin (non-expanded-spectrum cephalosporin), and benzylpenicillin at 1...
  25. Krauss J, Hakenbeck R. A mutation in the D,D-carboxypeptidase penicillin-binding protein 3 of Streptococcus pneumoniae contributes to cefotaxime resistance of the laboratory mutant C604. Antimicrob Agents Chemother. 1997;41:936-42 pubmed
    b>Cefotaxime resistance in laboratory mutant C604 of Streptococcus pneumoniae, for which the MIC is 1.5 microg/ml, is independent of alterations in high-molecular-mass penicillin-binding protein (PBP) 1a...
  26. Kim D, Lym Y, Jang S, Han H, Kim Y, Chung C, et al. In vitro efficacy of the combination of ciprofloxacin and cefotaxime against Vibrio vulnificus. Antimicrob Agents Chemother. 2005;49:3489-91 pubmed
    We performed time-kill studies of antimicrobial combinations that included minocycline, cefotaxime, and ciprofloxacin with Vibrio vulnificus ATCC 27562. Cefotaxime-plus-ciprofloxacin combinations acted synergistically against V...
  27. Gniadkowski M, Schneider I, Pa ucha A, Jungwirth R, Mikiewicz B, Bauernfeind A. Cefotaxime-resistant Enterobacteriaceae isolates from a hospital in Warsaw, Poland: identification of a new CTX-M-3 cefotaxime-hydrolyzing beta-lactamase that is closely related to the CTX-M-1/MEN-1 enzyme. Antimicrob Agents Chemother. 1998;42:827-32 pubmed
    A group of cefotaxime-resistant Citrobacter freundii and Escherichia coli isolates were collected by a clinical laboratory in a hospital in Warsaw, Poland, in July 1996...
  28. Bradford P, Urban C, Jaiswal A, Mariano N, Rasmussen B, Projan S, et al. SHV-7, a novel cefotaxime-hydrolyzing beta-lactamase, identified in Escherichia coli isolates from hospitalized nursing home patients. Antimicrob Agents Chemother. 1995;39:899-905 pubmed
    ..Strains MCQ-2, MCQ-3, and MCQ-4 were also noted to be resistant to cefotaxime. These three strains produced two beta-lactamases with pIs of 5.4 (TEM-1) and 7.6...
  29. Laible G, Hakenbeck R, Sicard M, Joris B, Ghuysen J. Nucleotide sequences of the pbpX genes encoding the penicillin-binding proteins 2x from Streptococcus pneumoniae R6 and a cefotaxime-resistant mutant, C506. Mol Microbiol. 1989;3:1337-48 pubmed
    ..PBP2x is one of the high-Mr PBPs which appears to be altered both in resistant clinical isolates, and in cefotaxime-resistant laboratory mutants...
  30. Woo P, Tam D, Lau S, Fung A, Yuen K. Enterococcus cecorum empyema thoracis successfully treated with cefotaxime. J Clin Microbiol. 2004;42:919-22 pubmed
    ..The patient responded to cefotaxime (MIC, 0.25 microg/ml) treatment and drainage of the empyema. Susceptibility of E...
  31. Negri M, Lipsitch M, Blazquez J, Levin B, Baquero F. Concentration-dependent selection of small phenotypic differences in TEM beta-lactamase-mediated antibiotic resistance. Antimicrob Agents Chemother. 2000;44:2485-91 pubmed
  32. Nukaga M, Kumar S, Nukaga K, Pratt R, Knox J. Hydrolysis of third-generation cephalosporins by class C beta-lactamases. Structures of a transition state analog of cefotoxamine in wild-type and extended spectrum enzymes. J Biol Chem. 2004;279:9344-52 pubmed
    ..freundii enzymes, the ES GC1 beta-lactamase is able to rapidly hydrolyze third-generation cephalosporins such as cefotaxime and ceftazidime...
  33. Kuhn F, Cottagnoud M, Acosta F, Flatz L, Entenza J, Cottagnoud P. Cefotaxime acts synergistically with levofloxacin in experimental meningitis due to penicillin-resistant pneumococci and prevents selection of levofloxacin-resistant mutants in vitro. Antimicrob Agents Chemother. 2003;47:2487-91 pubmed
    b>Cefotaxime, given in two doses (each 100 mg/kg of body weight), produced a good bactericidal activity (-0.47 Deltalog(10) CFU/ml. h) which was comparable to that of levofloxacin (-0.49 Deltalog(10) CFU/ml...
  34. Sabat M, Tarrag R, Navarro F, Mir E, Verg s C, Barb J, et al. Cloning and sequence of the gene encoding a novel cefotaxime-hydrolyzing beta-lactamase (CTX-M-9) from Escherichia coli in Spain. Antimicrob Agents Chemother. 2000;44:1970-3 pubmed
    A new CTX-M-type beta-lactamase (CTX-M-9) has been cloned from a clinical cefotaxime-resistant Escherichia coli strain...
  35. Ko W, Lee H, Chuang Y, Ten S, Su C, Wu J. In vitro and in vivo combinations of cefotaxime and minocycline against Aeromonas hydrophila. Antimicrob Agents Chemother. 2001;45:1281-3 pubmed
    The activities of cefotaxime and minocycline against Aeromonas hydrophila were investigated. Cefotaxime (4 times the MIC) plus minocycline (0...
  36. Bonnet R, Dutour C, Sampaio J, Chanal C, Sirot D, Labia R, et al. Novel cefotaximase (CTX-M-16) with increased catalytic efficiency due to substitution Asp-240-->Gly. Antimicrob Agents Chemother. 2001;45:2269-75 pubmed
    ..The CTX-M-16-producing E. coli transformant exhibited the same level of resistance to cefotaxime (MIC, 16 microg/ml) but had a higher MIC of ceftazidime (MIC, 8 versus 1 microg/ml) than the CTX-M-9-producing ..
  37. Muller M, Haag O, Burgdorff T, Georgopoulos A, Weninger W, Jansen B, et al. Characterization of peripheral-compartment kinetics of antibiotics by in vivo microdialysis in humans. Antimicrob Agents Chemother. 1996;40:2703-9 pubmed
    ..This novel information may be useful for the rational development of dosage schedules and may improve predictions regarding therapeutic outcome. ..
  38. Cheung T, Chu Y, Chu M, Ma C, Yung R, Kam K. Plasmid-mediated resistance to ciprofloxacin and cefotaxime in clinical isolates of Salmonella enterica serotype Enteritidis in Hong Kong. J Antimicrob Chemother. 2005;56:586-9 pubmed
    To characterize the genetic determinants involved in the reduced susceptibility to ciprofloxacin and cefotaxime in Salmonella enterica serotype Enteritidis clinical isolates obtained from four patients in summer 2003 in Hong Kong...
  39. Orencia M, Yoon J, Ness J, Stemmer W, Stevens R. Predicting the emergence of antibiotic resistance by directed evolution and structural analysis. Nat Struct Biol. 2001;8:238-42 pubmed publisher
    ..coli-based directed evolution technique with cefotaxime selection...
  40. Braga P, Ricci D. Atomic force microscopy: application to investigation of Escherichia coli morphology before and after exposure to cefodizime. Antimicrob Agents Chemother. 1998;42:18-22 pubmed
  41. Kon M, Kurazono T, Ohshima M, Yamaguchi M, Morita K, Watanabe N, et al. [Cefotaxime-resistant shiga toxin-producing Escherichia coli O26 : H11 isolated from a patient with diarrhea]. Kansenshogaku Zasshi. 2005;79:161-8 pubmed
    A shiga toxin-producing Escherichia coli (STEC) O26 strain resistant to cefotaxime (CTX) and cefpodoxime (but not ceftazidime) was isolated from the faecal sample of a 17-year-old outpatient with diarrhea...
  42. Stemmer W. Rapid evolution of a protein in vitro by DNA shuffling. Nature. 1994;370:389-91 pubmed
    ..non-essential mutations, were each followed by selection on increasing concentrations of the antibiotic cefotaxime. We report here that selected mutants had a minimum inhibitory concentration of 640 micrograms ml-1, a 32,000-..
  43. Oliver A, P rez D az J, Coque T, Baquero F, Cant n R. Nucleotide sequence and characterization of a novel cefotaxime-hydrolyzing beta-lactamase (CTX-M-10) isolated in Spain. Antimicrob Agents Chemother. 2001;45:616-20 pubmed publisher
    A cefotaxime-resistant, ceftazidime-susceptible Escherichia coli isolate was obtained from a patient with sepsis in 1997, from which a beta-lactamase with a pI of 8.1 was cloned...
  44. Hayes R, Bentzien J, Ary M, Hwang M, Jacinto J, Vielmetter J, et al. Combining computational and experimental screening for rapid optimization of protein properties. Proc Natl Acad Sci U S A. 2002;99:15926-31 pubmed
    ..then constructed and experimentally screened to select for variants with improved resistance to the antibiotic cefotaxime. In a single round, we obtained variants exhibiting a 1,280-fold increase in resistance...
  45. Dutta B, Debnath S, Mandal T, Chakraborty A. Modification of pharmacokinetics of cefotaxime in uranyl nitrate-induced renal damage in black bengal goats. J Vet Sci. 2004;5:1-3 pubmed
    Pharmacokinetics of cefotaxime (50 mg/kg, i.m.) were studied in both healthy and kidney damaged female black Bengal goats. Uranyl nitrate (0...
  46. Smith A, Feldman C, Massidda O, McCarthy K, Ndiweni D, Klugman K. Altered PBP 2A and its role in the development of penicillin, cefotaxime, and ceftriaxone resistance in a clinical isolate of Streptococcus pneumoniae. Antimicrob Agents Chemother. 2005;49:2002-7 pubmed publisher
    ..Notably, compared to isolates 1 and 2, isolate 3 showed a decrease in penicillin, cefotaxime, and ceftriaxone resistance...
  47. Wang R, Jia Z, Fan J, Ma J, Hua X, Zhang Q, et al. Separation and determination of cefotaxime enantiomers in injections by capillary zone electrophoresis. Pharmazie. 2009;64:156-60 pubmed
    b>Cefotaxime enantiomers have specific effects on Gram-negative bacteria...
  48. Cafini F, Aguilar L, Alou L, Gimenez M, Sevillano D, Torrico M, et al. Cidal activity of oral third-generation cephalosporins against Streptococcus pneumoniae in relation to cefotaxime intrinsic activity. Eur J Clin Microbiol Infect Dis. 2008;27:679-83 pubmed publisher
    ..within 12 h of four oral third-generation cephalosporins against ten Streptococcus pneumoniae strains exhibiting cefotaxime minimum inhibitory concentrations (MICs) from 0.03 to 2 microg/ml...
  49. Tena D, Gonzalez Praetorius A, Pérez Pomata M, Bisquert J. [Rapidly progressive myonecrosis by Aeromonas veronii biotype sobria]. An Med Interna. 2006;23:540-2 pubmed
    ..was not favourable and surgical amputation of left leg was performed in spite of antibiotic treatment with cefotaxime and tobramicin...
  50. Shrestha B, Tada T, Miyoshi Akiyama T, Shimada K, Ohara H, Kirikae T, et al. Identification of a novel NDM variant, NDM-13, from a multidrug-resistant Escherichia coli clinical isolate in Nepal. Antimicrob Agents Chemother. 2015;59:5847-50 pubmed publisher
    ..However, NDM-13 displayed significantly higher k cat/Km ratios for cefotaxime. The genetic environment of bla NDM-13 was determined to be tnpA-IS30-bla NDM-13-ble MBL-trpF-dsbC-cutA-groES-..
  51. Li D, Liu Q, Song X, Zhang J, Xu C, Yang X. [Biological and molecular characteristics of a cat-borne Bartonella clarridgeiae]. Wei Sheng Wu Xue Bao. 2009;49:429-37 pubmed
    ..The strain was susceptible to Cefotaxime sodium, Rifampin, Ciprofloxacin and other four antibiotics...
  52. Sinha A, Kempley S, Price E, Sharma B, Livermore D. Early onset Morganella morganii sepsis in a newborn infant with emergence of cephalosporin resistance caused by depression of AMPC beta-lactamase production. Pediatr Infect Dis J. 2006;25:376-7 pubmed
    A preterm infant with early onset Morganella morganii sepsis was treated with cefotaxime and gentamicin after confirmation of antimicrobial susceptibility...
  53. Pérez Llarena F, Cartelle M, Mallo S, Beceiro A, Perez A, Villanueva R, et al. Structure-function studies of arginine at position 276 in CTX-M beta-lactamases. J Antimicrob Chemother. 2008;61:792-7 pubmed publisher
    ..We also investigated the role of Arg276 in cefotaxime hydrolysis...