carbapenems

Summary

Summary: A group of beta-lactam antibiotics in which the sulfur atom in the thiazolidine ring of the penicillin molecule is replaced by a carbon atom. THIENAMYCINS are a subgroup of carbapenems which have a sulfur atom as the first constituent of the side chain.

Top Publications

  1. Zilberberg M, Shorr A. Prevalence of multidrug-resistant Pseudomonas aeruginosa and carbapenem-resistant Enterobacteriaceae among specimens from hospitalized patients with pneumonia and bloodstream infections in the United States from 2000 to 2009. J Hosp Med. 2013;8:559-63 pubmed publisher
    ..Carbapenem-resistant Enterobacteriaceae (CRE) have emerged as a pathogen of concern over the past decade...
  2. Girlich D, Poirel L, Nordmann P. Comparison of the SUPERCARBA, CHROMagar KPC, and Brilliance CRE screening media for detection of Enterobacteriaceae with reduced susceptibility to carbapenems. Diagn Microbiol Infect Dis. 2013;75:214-7 pubmed publisher
    ..SUPERCARBA medium was evaluated together with 2 commercially available selective culture media containing carbapenems: CHROMagar KPC (CHROMagar) and Brilliance CRE (Oxoid, Thermofisher Scientific)...
  3. Hussein K, Raz Pasteur A, Finkelstein R, Neuberger A, Shachor Meyouhas Y, Oren I, et al. Impact of carbapenem resistance on the outcome of patients' hospital-acquired bacteraemia caused by Klebsiella pneumoniae. J Hosp Infect. 2013;83:307-13 pubmed publisher
    ..Bloodstream infections (BSIs) caused by these strains have been associated with high rates of treatment failure and mortality...
  4. Falagas M, Tansarli G, Kapaskelis A, Vardakas K. Ertapenem use and antimicrobial resistance to group 2 carbapenems in Gram-negative infections: a systematic review. Expert Rev Anti Infect Ther. 2013;11:69-78 pubmed publisher
    ..of ertapenem use on the resistance of Gram-negative bacteria (in general and in specific species) to group 2 carbapenems. PubMed and Scopus databases were systematically searched...
  5. Liu C, Tang C, Kuo H, Lu C, Chang K, Liou M. The origin of Acinetobacter baumannii TYTH-1: a comparative genomics study. Int J Antimicrob Agents. 2013;41:318-24 pubmed publisher
    ..The global spread of CRAB is now a worldwide public health problem. In Taiwan, the government needs to focus more attention on the importance of identifying and tracing resistant pathogens and issuing notifications of CRAB infections...
  6. Kempf M, Rolain J, Azza S, Diene S, Joly Guillou M, Dubourg G, et al. Investigation of Acinetobacter baumannii resistance to carbapenems in Marseille hospitals, south of France: a transition from an epidemic to an endemic situation. APMIS. 2013;121:64-71 pubmed publisher
    ..These results demonstrate a current evolution in the A. baumannii epidemiology in Marseille with a switch from an epidemic situation to an endemic situation and with several circulating clones...
  7. Falagas M, Tansarli G, Ikawa K, Vardakas K. Clinical outcomes with extended or continuous versus short-term intravenous infusion of carbapenems and piperacillin/tazobactam: a systematic review and meta-analysis. Clin Infect Dis. 2013;56:272-82 pubmed publisher
    We sought to study whether the better pharmacokinetic and pharmacodynamic (PK/PD) properties of carbapenems and piperacillin/tazobactam, when the duration of infusion is longer, were associated with lower mortality...
  8. Prabaker K, Lin M, McNally M, Cherabuddi K, Ahmed S, Norris A, et al. Transfer from high-acuity long-term care facilities is associated with carriage of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae: a multihospital study. Infect Control Hosp Epidemiol. 2012;33:1193-9 pubmed publisher
    ..To determine whether transfer from a long-term care facility (LTCF) is a risk factor for colonization with Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae upon acute care hospital admission...
  9. Hofer B, Dantier C, Gebhardt K, Desarbre E, Schmitt Hoffmann A, Page M. Combined effects of the siderophore monosulfactam BAL30072 and carbapenems on multidrug-resistant Gram-negative bacilli. J Antimicrob Chemother. 2013;68:1120-9 pubmed publisher
    ..monosulfactam antibiotic BAL30072 is stable to most carbapenemases, suggesting that it could be complementary to carbapenems. We have investigated the antimicrobial activity of BAL30072 combined with imipenem, meropenem and doripenem.

More Information

Publications91

  1. Braykov N, Eber M, Klein E, Morgan D, Laxminarayan R. Trends in resistance to carbapenems and third-generation cephalosporins among clinical isolates of Klebsiella pneumoniae in the United States, 1999-2010. Infect Control Hosp Epidemiol. 2013;34:259-68 pubmed publisher
    ..We examined national trends in the proportion of Klebsiella pneumoniae isolates resistant to carbapenems (CRKP) and third-generation cephalosporins (G3CRKP).
  2. Correa L, Martino M, Siqueira I, Pasternak J, Gales A, Silva C, et al. A hospital-based matched case-control study to identify clinical outcome and risk factors associated with carbapenem-resistant Klebsiella pneumoniae infection. BMC Infect Dis. 2013;13:80 pubmed publisher
    ..The aim of this study was to describe the epidemiology and clinical outcomes associated with carbapenem-resistant K. pneumoniae and to determine the antimicrobial resistance mechanisms...
  3. Breilh D, Texier Maugein J, Allaouchiche B, Saux M, Boselli E. Carbapenems. J Chemother. 2013;25:1-17 pubmed publisher
    To assess the relative strengths and weaknesses of carbapenems by considering their microbiological, clinical, pharmacokinetics and pharmacokinetic/pharmacodynamic (PK/PD) properties and defining optimal conditions of uses of the new ..
  4. Higgins P, Pérez Llarena F, Zander E, Fernandez A, Bou G, Seifert H. OXA-235, a novel class D ?-lactamase involved in resistance to carbapenems in Acinetobacter baumannii. Antimicrob Agents Chemother. 2013;57:2121-6 pubmed publisher
    ..In addition, the presence of these acquired ?-lactamase genes might result from a transposition-mediated mechanism. This highlights the propensity of A. baumannii to acquire multiple carbapenem resistance determinants...
  5. Jean S, Hsueh P, Lee W, Yu K, Liao C, Chang F, et al. Carbapenem susceptibilities and non-susceptibility concordance to different carbapenems amongst clinically important Gram-negative bacteria isolated from intensive care units in Taiwan: results from the Surveillance of Multicentre Antimicrobial Resis. Int J Antimicrob Agents. 2013;41:457-62 pubmed publisher
    To investigate the in vitro susceptibilities to various carbapenems amongst clinical Gram-negative bacteria isolated from patients in intensive care units of ten major teaching hospitals in Taiwan in 2009, a survey was conducted to ..
  6. Chiu S, Wu T, Chuang Y, Lin J, Fung C, Lu P, et al. National surveillance study on carbapenem non-susceptible Klebsiella pneumoniae in Taiwan: the emergence and rapid dissemination of KPC-2 carbapenemase. PLoS ONE. 2013;8:e69428 pubmed publisher
    ..To establish nationwide data on CnSKP spread and carbapenem-resistance mechanisms, we conducted a national surveillance study in Taiwanese hospitals...
  7. Guzek A, Korzeniewski K, Nitsch Osuch A, Rybicki Z, Prokop E. In vitro sensitivity of Acinetobacter baumannii and Pseudomonas aeruginosa to carbapenems among intensive care unit patients. Adv Exp Med Biol. 2013;788:109-16 pubmed publisher
    ..b>Carbapenems remain a group of antibiotics characterized by the highest effectiveness in treatment of heavy infections of ..
  8. Kim S, Shin J, Shin S, Ko K. Characteristics of carbapenem-resistant Enterobacteriaceae isolates from Korea. Diagn Microbiol Infect Dis. 2013;76:486-90 pubmed publisher
    ..pneumoniae isolates (ST340) was determined. Polymyxin- and tigecycline-resistant CRE isolates were also identified, which limits treatment options for infections causes by these organisms. ..
  9. Routsi C, Pratikaki M, Platsouka E, Sotiropoulou C, Papas V, Pitsiolis T, et al. Risk factors for carbapenem-resistant Gram-negative bacteremia in intensive care unit patients. Intensive Care Med. 2013;39:1253-61 pubmed publisher
    ..Carbapenem-resistant (CR) Gram-negative pathogens have increased substantially. This study was performed to identify the risk factors for development of CR Gram-negative bacteremia (GNB) in intensive care unit (ICU) patients...
  10. Alp E, Percin D, Colakoglu S, Durmaz S, Kürkcü C, Ekincioğlu P, et al. Molecular characterization of carbapenem-resistant Klebsiella pneumoniae in a tertiary university hospital in Turkey. J Hosp Infect. 2013;84:178-80 pubmed publisher
    ..2% produced imipenem. This study adds Turkey to the growing list of countries with NDM-1-producing bacteria and shows that NDM-1 may easily spread worldwide...
  11. Ansaldi F, Canepa P, Bassetti M, Zancolli M, Molinari M, Talamini A, et al. Sequential outbreaks of multidrug-resistant Acinetobacter baumannii in intensive care units of a tertiary referral hospital in Italy: combined molecular approach for epidemiological investigation. J Hosp Infect. 2011;79:134-40 pubmed publisher
    ..A molecular approach allowed the prompt introduction of infection control measures and the evaluation of data in a global epidemiological context. ..
  12. Lin Y, Sheng W, Chen Y, Chang S, Hsia K, Li S. Differences in carbapenem resistance genes among Acinetobacterbaumannii, Acinetobacter genospecies 3 and Acinetobacter genospecies 13TU in Taiwan. Int J Antimicrob Agents. 2010;35:439-43 pubmed publisher
    ..Of the 81 isolates, 40 (49%) were resistant to carbapenems. Most A. baumannii isolates (47/53, 88...
  13. Wang J, Zhou J, Qu T, Shen P, Wei Z, Yu Y, et al. Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Chinese hospitals. Int J Antimicrob Agents. 2010;35:486-91 pubmed publisher
    ..were analysed for expression of the chromosomal beta-lactamase (AmpC), the porin important for entry of carbapenems (OprD) and an efflux system (MexAB-OprM) known to extrude some beta-lactams...
  14. Torres M, Blanca M. The complex clinical picture of beta-lactam hypersensitivity: penicillins, cephalosporins, monobactams, carbapenems, and clavams. Med Clin North Am. 2010;94:805-20, xii pubmed publisher
    ..The natural history of IgE-mediated reactions indicates that the count of specific IgE antibodies decreases over time and that results of diagnostic tests can become negative...
  15. Borer A, Saidel Odes L, Eskira S, Nativ R, Riesenberg K, Livshiz Riven I, et al. Risk factors for developing clinical infection with carbapenem-resistant Klebsiella pneumoniae in hospital patients initially only colonized with carbapenem-resistant K pneumoniae. Am J Infect Control. 2012;40:421-5 pubmed publisher
    ..This study examined predictors of carbapenem-resistant Klebsiella pneumoniae (CRKP) colonization and risk factors for the development of CRKP infection in patients initially only colonized with CRKP...
  16. Llarrull L, Testero S, Fisher J, Mobashery S. The future of the ?-lactams. Curr Opin Microbiol. 2010;13:551-7 pubmed publisher
    ..We concisely summarize recent developments with respect to bacterial resistance, the identity of the new ?-lactams, and the emerging non-empirical strategies that will ensure that this incredible class of antibiotics has a future. ..
  17. Nguyen M, Eschenauer G, Bryan M, O Neil K, Furuya E, Della Latta P, et al. Carbapenem-resistant Klebsiella pneumoniae bacteremia: factors correlated with clinical and microbiologic outcomes. Diagn Microbiol Infect Dis. 2010;67:180-4 pubmed publisher
    ..Our data suggest that severity of illness, rapid microbiologic eradication, and source control are crucial factors in the outcomes of patients with CRKP bacteremia. ..
  18. Routsi C, Pratikaki M, Platsouka E, Sotiropoulou C, Nanas S, Markaki V, et al. Carbapenem-resistant versus carbapenem-susceptible Acinetobacter baumannii bacteremia in a Greek intensive care unit: risk factors, clinical features and outcomes. Infection. 2010;38:173-80 pubmed publisher
    ..Although, by univariate analysis, patients with CRAB were more likely to have had exposure to colistin, carbapenems and linezolid, multivariate analysis did not revealed any significant association...
  19. Jernigan M, Press E, Nguyen M, Clancy C, Shields R. The combination of doripenem and colistin is bactericidal and synergistic against colistin-resistant, carbapenemase-producing Klebsiella pneumoniae. Antimicrob Agents Chemother. 2012;56:3395-8 pubmed publisher
    ..All other combinations were inferior. We are currently evaluating the combination of doripenem and colistin as a frontline therapy for KPC infection. ..
  20. Zarrilli R, Giannouli M, Tomasone F, Triassi M, Tsakris A. Carbapenem resistance in Acinetobacter baumannii: the molecular epidemic features of an emerging problem in health care facilities. J Infect Dev Ctries. 2009;3:335-41 pubmed
    ..b>Carbapenems have been widely used to treat serious multidrug-resistant A...
  21. Satlin M, Kubin C, Blumenthal J, Cohen A, Furuya E, Wilson S, et al. Comparative effectiveness of aminoglycosides, polymyxin B, and tigecycline for clearance of carbapenem-resistant Klebsiella pneumoniae from urine. Antimicrob Agents Chemother. 2011;55:5893-9 pubmed publisher
    ..Treatment with an aminoglycoside, when active in vitro, was associated with a significantly higher rate of microbiologic clearance of CRKP bacteriuria than treatment with either polymyxin B or tigecycline...
  22. Yang Q, Wang H, Sun H, Chen H, Xu Y, Chen M. Phenotypic and genotypic characterization of Enterobacteriaceae with decreased susceptibility to carbapenems: results from large hospital-based surveillance studies in China. Antimicrob Agents Chemother. 2010;54:573-7 pubmed publisher
    The resistance mechanism of 49 Enterobacteriaceae isolates with decreased susceptibility to carbapenems collected from 2004 to 2008 at 16 teaching hospitals in China was investigated...
  23. Papp Wallace K, Endimiani A, Taracila M, Bonomo R. Carbapenems: past, present, and future. Antimicrob Agents Chemother. 2011;55:4943-60 pubmed publisher
    ..Among the ?-lactams currently available, carbapenems are unique because they are relatively resistant to hydrolysis by most ?-lactamases, in some cases act as "..
  24. Prates C, Martins A, Superti S, Lopes F, Ramos F, Cantarelli V, et al. Risk factors for 30-day mortality in patients with carbapenem-resistant Acinetobacter baumannii during an outbreak in an intensive care unit. Epidemiol Infect. 2011;139:411-8 pubmed publisher
    ..Patients who received appropriate therapy tended to have lower mortality rates, although therapy was started late and dosage was suboptimal in most cases. ..
  25. García Sureda L, Doménech Sánchez A, Barbier M, Juan C, Gascó J, Alberti S. OmpK26, a novel porin associated with carbapenem resistance in Klebsiella pneumoniae. Antimicrob Agents Chemother. 2011;55:4742-7 pubmed publisher
    Clinical isolates of Klebsiella pneumoniae resistant to carbapenems are being isolated with increasing frequency. Loss of the expression of the major nonspecific porins OmpK35/36 is a frequent feature in these isolates...
  26. Deshpande P, Rodrigues C, Shetty A, Kapadia F, Hedge A, Soman R. New Delhi Metallo-beta lactamase (NDM-1) in Enterobacteriaceae: treatment options with carbapenems compromised. J Assoc Physicians India. 2010;58:147-9 pubmed
    b>Carbapenems are among the few useful antibiotics against multidrug resistant gram negative bacteria particularly those with extended spectrum beta lactamase...
  27. Chan J, Graves J, Dellit T. Antimicrobial treatment and clinical outcomes of carbapenem-resistant Acinetobacter baumannii ventilator-associated pneumonia. J Intensive Care Med. 2010;25:343-8 pubmed publisher
    ..However, colistin-related nephrotoxicity was much higher than recently reported and decreased susceptibility to tigecycline emerged on therapy demonstrating the limitations of alternative regimens. ..
  28. Harris P, Ferguson J. Antibiotic therapy for inducible AmpC ?-lactamase-producing Gram-negative bacilli: what are the alternatives to carbapenems, quinolones and aminoglycosides?. Int J Antimicrob Agents. 2012;40:297-305 pubmed publisher
    ..drug susceptibilities for ESCPM organisms, encouraging alternative therapy with quinolones, aminoglycosides or carbapenems. However, quinolones and carbapenems present problems with selective pressure for multiresistant organisms, and ..
  29. Nicolau D, Carmeli Y, Crank C, Goff D, Graber C, Lima A, et al. Carbapenem stewardship: does ertapenem affect Pseudomonas susceptibility to other carbapenems? A review of the evidence. Int J Antimicrob Agents. 2012;39:11-5 pubmed publisher
    The group 2 carbapenems (imipenem, meropenem and, more recently, doripenem) have been a mainstay of treatment for patients with serious hospital infections caused by Pseudomonas aeruginosa, Enterobacteriaceae and other difficult-to-treat ..
  30. Ben David D, Masarwa S, Navon Venezia S, Mishali H, Fridental I, Rubinovitch B, et al. Carbapenem-resistant Klebsiella pneumoniae in post-acute-care facilities in Israel. Infect Control Hosp Epidemiol. 2011;32:845-53 pubmed publisher
    ..18; P = .007), and screening within 90 days of the first culture growing CRKP (OR, 2.9; P = .012). We found a large reservoir of CRKP in PACFs. Infection-control policies and antibiotic exposure were associated with patient colonization. ..
  31. Kollef M, Nathwani D, Merchant S, Gast C, Quintana A, Ketter N. Medical resource utilization among patients with ventilator-associated pneumonia: pooled analysis of randomized studies of doripenem versus comparators. Crit Care. 2010;14:R84 pubmed publisher
    ..Differences in antipseudomonal activity may have contributed to these findings. ClinicalTrials.gov number NCT00211003 (study 1) and NCT00211016 (study 2). ..
  32. Fernandez Canigia L, Litterio M, Legaria M, Castello L, Predari S, Di Martino A, et al. First national survey of antibiotic susceptibility of the Bacteroides fragilis group: emerging resistance to carbapenems in Argentina. Antimicrob Agents Chemother. 2012;56:1309-14 pubmed publisher
    ..fragilis species and displaying reduced susceptibility or resistance to carbapenems (MICs ? 4 ?g/ml)...
  33. Perez F, Endimiani A, Ray A, Decker B, Wallace C, Hujer K, et al. Carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae across a hospital system: impact of post-acute care facilities on dissemination. J Antimicrob Chemother. 2010;65:1807-18 pubmed publisher
    Resistance to carbapenems among Acinetobacter baumannii and Klebsiella pneumoniae presents a serious therapeutic and infection control challenge. We describe the epidemiology and genetic basis of carbapenem resistance in A...
  34. Zhang R, Wang X, Cai J, Zhou H, Lv H, Hu Q, et al. Outbreak of Klebsiella pneumoniae carbapenemase 2-producing K. pneumoniae with high qnr prevalence in a Chinese hospital. J Med Microbiol. 2011;60:977-82 pubmed publisher
    ..PFGE analysis indicated that the 40 strains were all closely related. The MICs of carbapenems varied from 16 to >256 µg ml?¹...
  35. Credito K, Kosowska Shick K, Appelbaum P. Mutant prevention concentrations of four carbapenems against gram-negative rods. Antimicrob Agents Chemother. 2010;54:2692-5 pubmed publisher
    We tested the propensities of four carbapenems to select for resistant Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii mutants by determining the mutant prevention concentrations (MPCs) for ..
  36. Mavroidi A, Miriagou V, Malli E, Stefos A, Dalekos G, Tzouvelekis L, et al. Emergence of Escherichia coli sequence type 410 (ST410) with KPC-2 ?-lactamase. Int J Antimicrob Agents. 2012;39:247-50 pubmed publisher
    ..coli ST410 known to be associated with CTX-M production. Diffusion of bla(KPC-2) in common pathogens such as E. coli is of concern. ..
  37. Lumb J. Carbapenems in the treatment of intra-abdominal infection. Report from the 20th European Congress of Clinical Microbiology and Infectious Diseases. Vienna, Austria, 10-13 April 2010. Future Microbiol. 2010;5:1165-6 pubmed publisher
    ..Surveillance data suggest that carbapenem antibiotics are appropriate choices for the empiric treatment of intra-abdominal infection. ..
  38. Nordmann P, Poirel L, Walsh T, Livermore D. The emerging NDM carbapenemases. Trends Microbiol. 2011;19:588-95 pubmed publisher
    b>Carbapenems were the last ?-lactams retaining near-universal anti-Gram-negative activity, but carbapenemases are spreading, conferring resistance...
  39. Munoz Price L, Hayden M, Lolans K, Won S, Calvert K, Lin M, et al. Successful control of an outbreak of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae at a long-term acute care hospital. Infect Control Hosp Epidemiol. 2010;31:341-7 pubmed publisher
    ..A bundled intervention was successful in preventing horizontal spread of KPC-producing gram-negative rods in a long-term acute care hospital, despite ongoing admission of patients colonized with KPC producers. ..
  40. Pfeifer Y, Cullik A, Witte W. Resistance to cephalosporins and carbapenems in Gram-negative bacterial pathogens. Int J Med Microbiol. 2010;300:371-9 pubmed publisher
    ..Especially the increasing resistance to 3rd and 4th generation cephalosporins and carbapenems is of particular concern...
  41. Gaibani P, Ambretti S, Berlingeri A, Cordovana M, Farruggia P, Panico M, et al. Outbreak of NDM-1-producing Enterobacteriaceae in northern Italy, July to August 2011. Euro Surveill. 2011;16:20027 pubmed
    ..Our findings suggest ongoing spread of this carbapenem-resistance gene in Italy and highlight the need for intensive surveillance...
  42. Livermore D, Mushtaq S, Warner M, Zhang J, Maharjan S, Doumith M, et al. Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates. J Antimicrob Chemother. 2011;66:48-53 pubmed publisher
    ..They included 53 Klebsiella spp., 19 Enterobacter spp., 6 Escherichia coli and 4 others; most were multiresistant. Genes were identified by PCR and sequencing; MICs were measured by CLSI agar dilution...
  43. Shu J, Chia J, Siu L, Kuo A, Huang S, Su L, et al. Interplay between mutational and horizontally acquired resistance mechanisms and its association with carbapenem resistance amongst extensively drug-resistant Pseudomonas aeruginosa (XDR-PA). Int J Antimicrob Agents. 2012;39:217-22 pubmed publisher
    ..contributions to a low to intermediate MIC(50) (minimum inhibitory concentration for 50% of the organisms) for carbapenems. Isolates with reduced OprD expression that simultaneously harboured bla(VIM) exhibited high levels of ..
  44. Borer A, Saidel Odes L, Riesenberg K, Eskira S, Peled N, Nativ R, et al. Attributable mortality rate for carbapenem-resistant Klebsiella pneumoniae bacteremia. Infect Control Hosp Epidemiol. 2009;30:972-6 pubmed publisher
    ..To determine the attributable (direct) mortality and morbidity caused by carbapenem-resistant Klebsiella pneumoniae bacteremia...
  45. Beovic B, Kreft S, Seme K, Cizman M. Does ertepenem alter the susceptibility of Pseudomonas aeruginosa to carbapenems?. J Chemother. 2011;23:216-20 pubmed
    ..There is no evidence that ertapenem alters the P. aeruginosa susceptibility to carbapenems, but the relationship deserves further observation.
  46. Jovcic B, Lepsanovic Z, Suljagić V, Rackov G, Begovic J, Topisirovic L, et al. Emergence of NDM-1 metallo-?-lactamase in Pseudomonas aeruginosa clinical isolates from Serbia. Antimicrob Agents Chemother. 2011;55:3929-31 pubmed publisher
    ..Five additional isolates from different patients clonally related to either MMA83 or MMA533 were found to be NDM-1 positive...
  47. Carretto E, Barbarini D, Dijkshoorn L, van der Reijden T, Brisse S, Passet V, et al. Widespread carbapenem resistant Acinetobacter baumannii clones in Italian hospitals revealed by a multicenter study. Infect Genet Evol. 2011;11:1319-26 pubmed publisher
    Population diversity, susceptibility to antibiotics including carbapenems of 277 Acinetobacter baumannii strains collected in 17 Italian hospitals over a 6-months' period was assessed...
  48. Nordmann P, Picazo J, Mutters R, Korten V, Quintana A, Laeuffer J, et al. Comparative activity of carbapenem testing: the COMPACT study. J Antimicrob Chemother. 2011;66:1070-8 pubmed publisher
    ..The COMParative Activity of Carbapenem Testing (COMPACT) study compared the susceptibility of common Gram-negative bacilli causing serious infections in hospitalized patients with doripenem, imipenem and meropenem...
  49. Burckhardt I, Zimmermann S. Using matrix-assisted laser desorption ionization-time of flight mass spectrometry to detect carbapenem resistance within 1 to 2.5 hours. J Clin Microbiol. 2011;49:3321-4 pubmed publisher
    ..This method works for strains carrying NDM-1, VIM-1, VIM-2, KPC-2, and different IMP enzymes...
  50. Esterly J, Griffith M, Qi C, Malczynski M, Postelnick M, Scheetz M. Impact of carbapenem resistance and receipt of active antimicrobial therapy on clinical outcomes of Acinetobacter baumannii bloodstream infections. Antimicrob Agents Chemother. 2011;55:4844-9 pubmed publisher
    ..Inactive therapy was more important than carbapenem susceptibility with respect to outcomes, was a strong predictor of death, and is potentially modifiable...
  51. Zacharczuk K, Piekarska K, Szych J, Zawidzka E, Sulikowska A, Wardak S, et al. Emergence of Klebsiella pneumoniae coproducing KPC-2 and 16S rRNA methylase ArmA in Poland. Antimicrob Agents Chemother. 2011;55:443-6 pubmed publisher
    ..XbaI pulsed-field gel electrophoresis (PFGE) revealed 93.2% similarity of the isolates. All the isolates were resistant to carbapenems and 4,6-disubstituted 2-deoxystreptamines.
  52. Karah N, Giske C, Sundsfjord A, Samuelsen Ø. A diversity of OXA-carbapenemases and class 1 integrons among carbapenem-resistant Acinetobacter baumannii clinical isolates from Sweden belonging to different international clonal lineages. Microb Drug Resist. 2011;17:545-9 pubmed publisher
    ..In conclusion, a variety of clonal lineages, OXA-carbapenemases genes and genetic structures, and class 1 integrons were detected among carbapenem-resistant A. baumannii from Sweden...
  53. Ben David D, Maor Y, Keller N, Regev Yochay G, Tal I, Shachar D, et al. Potential role of active surveillance in the control of a hospital-wide outbreak of carbapenem-resistant Klebsiella pneumoniae infection. Infect Control Hosp Epidemiol. 2010;31:620-6 pubmed publisher
    ..The recent emergence of carbapenem resistance among Enterobacteriaceae is a major threat for hospitalized patients, and effective strategies are needed...
  54. Tsakris A, Voulgari E, Poulou A, Kimouli M, Pournaras S, Ranellou K, et al. In vivo acquisition of a plasmid-mediated bla(KPC-2) gene among clonal isolates of Serratia marcescens. J Clin Microbiol. 2010;48:2546-9 pubmed publisher
    ..to a Greek hospital were infected with Serratia marcescens isolates that exhibited reduced susceptibility to carbapenems and harbored Klebsiella pneumoniae carbapenemase (KPC) enzymes...
  55. Shi D, Wang W, Kuai S, Shao H, Huang M. Identification of bla KPC-2 on different plasmids of three Morganella morganii isolates. Eur J Clin Microbiol Infect Dis. 2012;31:797-803 pubmed publisher
    Three Morganella morganii strains resistant to carbapenems were recovered from the surgical intensive care unit (SICU) in our hospital...
  56. Poirel L, Potron A, Nordmann P. OXA-48-like carbapenemases: the phantom menace. J Antimicrob Chemother. 2012;67:1597-606 pubmed publisher
    ..The enzymes hydrolyse penicillins at a high level and carbapenems at a low level, sparing broad-spectrum cephalosporins, and are not susceptible to ?-lactamase inhibitors...
  57. Vashist J, Tiwari V, Das R, Kapil A, Rajeswari M. Analysis of penicillin-binding proteins (PBPs) in carbapenem resistant Acinetobacter baumannii. Indian J Med Res. 2011;133:332-8 pubmed
    ..In the recent past A. baumannii had developed resistance against ?-lactams, even against carbapenems. Penicillin-binding proteins (PBPs) are crucial for the cell wall biosynthesis during cell proliferation and ..
  58. Adams Haduch J, Onuoha E, Bogdanovich T, Tian G, Marschall J, Urban C, et al. Molecular epidemiology of carbapenem-nonsusceptible Acinetobacter baumannii in the United States. J Clin Microbiol. 2011;49:3849-54 pubmed publisher
    ..S. hospitals constitute part of the global epidemic driven by CC92, but have unique STs other than ST92, which may be spreading by means of patient transfer between health care facilities within the United States...
  59. Lo A, Verrall R, Williams J, Stratton C, Della Latta P, Tang Y. Carbapenem resistance via the blaKPC-2 gene in Enterobacter cloacae blood culture isolate. South Med J. 2010;103:453-4 pubmed publisher
    ..To our knowledge, this is the first report of a nosocomial isolate with carbapenemase-mediated resistance causing infection in a patient from Tennessee...
  60. Hilliard J, Melton J, Hall L, Abbanat D, Fernandez J, Ward C, et al. Comparative effects of carbapenems on bacterial load and host immune response in a Klebsiella pneumoniae murine pneumonia model. Antimicrob Agents Chemother. 2011;55:836-44 pubmed publisher
  61. Ye J, Huang C, Shie S, Huang P, Su L, Chiu C, et al. Multidrug resistant Acinetobacter baumannii: risk factors for appearance of imipenem resistant strains on patients formerly with susceptible strains. PLoS ONE. 2010;5:e9947 pubmed publisher
    Multidrug resistant Acinetobacter baumannii (MDRAB) is an important nosocomial pathogen usually susceptible to carbapenems; however, growing number of imipenem resistant MDRAB (IR-MDRAB) poses further clinical challenge...
  62. Catel Ferreira M, Coadou G, Molle V, Mugnier P, Nordmann P, Siroy A, et al. Structure-function relationships of CarO, the carbapenem resistance-associated outer membrane protein of Acinetobacter baumannii. J Antimicrob Chemother. 2011;66:2053-6 pubmed publisher
    ..The aim of this study was to determine whether this porin may be a diffusion pathway for carbapenems in A. baumannii.
  63. Somily A, Absar M, Arshad M, Al Aska A, Shakoor Z, Fatani A, et al. Antimicrobial susceptibility patterns of multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii against carbapenems, colistin, and tigecycline. Saudi Med J. 2012;33:750-5 pubmed
    To examine susceptibility of Pseudomonas aeruginosa (P. aeruginosa) and Acinetobacter baumannii (A. baumannii ) against carbapenems along with colistin and tigecycline as alternative therapeutic options.
  64. Walsh T. Emerging carbapenemases: a global perspective. Int J Antimicrob Agents. 2010;36 Suppl 3:S8-14 pubmed publisher
    ..In particular, the media attention given to the NDM-1 metallo-?-lactamase has highlighted the global consequences of human behaviour on spreading antibiotic resistance...
  65. McGann P, Hang J, Clifford R, Yang Y, Kwak Y, Kuschner R, et al. Complete sequence of a novel 178-kilobase plasmid carrying bla(NDM-1) in a Providencia stuartii strain isolated in Afghanistan. Antimicrob Agents Chemother. 2012;56:1673-9 pubmed publisher
    ..The presence of multiple insertion sequences and transposons flanking the region containing the bla(NDM-1) gene further highlights the potential mobility associated with this gene...
  66. Nordmann P, Boulanger A, Poirel L. NDM-4 metallo-?-lactamase with increased carbapenemase activity from Escherichia coli. Antimicrob Agents Chemother. 2012;56:2184-6 pubmed publisher
    A clinical Escherichia coli isolate resistant to all ?-lactams, including carbapenems, expressed a novel metallo-?-lactamase (MBL), NDM-4, differing from NDM-1 by a single amino acid substitution (Met154Leu)...
  67. Chen T, Lee Y, Kuo S, Hsueh P, Chang F, Siu L, et al. Emergence and Distribution of Plasmids Bearing the blaOXA-51-like gene with an upstream ISAba1 in carbapenem-resistant Acinetobacter baumannii isolates in Taiwan. Antimicrob Agents Chemother. 2010;54:4575-81 pubmed publisher
    ..This study demonstrated that the carbapenem resistance-associated plasmids carrying the ISAba1-bla(OXA-51)-like gene are widespread in A. baumannii strains in Taiwan...
  68. Wiener Well Y, Rudensky B, Yinnon A, Kopuit P, Schlesinger Y, Broide E, et al. Carriage rate of carbapenem-resistant Klebsiella pneumoniae in hospitalised patients during a national outbreak. J Hosp Infect. 2010;74:344-9 pubmed publisher
    ..4%. The clonal origin of these isolates suggests that strict adherence to isolation procedure may contain this outbreak...
  69. Hawser S, Bouchillon S, Hoban D, Badal R, Canton R, Baquero F. Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antim. Antimicrob Agents Chemother. 2010;54:3043-6 pubmed publisher
    ..0% versus 6.5%, respectively, for E. coli (P < 0.001) and 20.9% versus 5.3%, respectively, for K. pneumoniae (P < 0.01). Carbapenems were consistently the most active drugs tested.
  70. Markelz A, Mende K, Murray C, Yu X, Zera W, Hospenthal D, et al. Carbapenem susceptibility testing errors using three automated systems, disk diffusion, Etest, and broth microdilution and carbapenem resistance genes in isolates of Acinetobacter baumannii-calcoaceticus complex. Antimicrob Agents Chemother. 2011;55:4707-11 pubmed publisher
    ..8 and 30.8%. International variability in carbapenem breakpoints and the absence of CLSI breakpoints for doripenem present a challenge in susceptibility testing...
  71. Livermore D, Mushtaq S, Morinaka A, Ida T, Maebashi K, Hope R. Activity of carbapenems with ME1071 (disodium 2,3-diethylmaleate) against Enterobacteriaceae and Acinetobacter spp. with carbapenemases, including NDM enzymes. J Antimicrob Chemother. 2013;68:153-8 pubmed publisher
    ME1071 is a maleic acid that inhibits metallo-?-lactamases (MBLs). We examined its ability to potentiate different carbapenems against MBL-producing Enterobacteriaceae in relation to its inhibition kinetics.
  72. Romanelli R, Jesus L, Clemente W, Lima S, Rezende E, Coutinho R, et al. Outbreak of resistant Acinetobacter baumannii- measures and proposal for prevention and control. Braz J Infect Dis. 2009;13:341-7 pubmed publisher
    ..Carbapenem and third-generation cephalosporin use displayed a tendency to be risk factors. Risk factors must be focused on infection control and prevention measures considering A. baumanni dissemination...
  73. Sánchez Romero I, Asensio A, Oteo J, Muñoz Algarra M, Isidoro B, Vindel A, et al. Nosocomial outbreak of VIM-1-producing Klebsiella pneumoniae isolates of multilocus sequence type 15: molecular basis, clinical risk factors, and outcome. Antimicrob Agents Chemother. 2012;56:420-7 pubmed publisher
    ..A high rate of associated mortality and great difficulty in controlling the spread of this clone, without permanent behavioral changes in the personnel, were observed...
  74. Hamidian M, Hall R. AbaR4 replaces AbaR3 in a carbapenem-resistant Acinetobacter baumannii isolate belonging to global clone 1 from an Australian hospital. J Antimicrob Chemother. 2011;66:2484-91 pubmed publisher
    ..To explore the diversity of genomic resistance islands in multiply antibiotic-resistant Acinetobacter baumannii isolates in global clone 1 (GC1) from Australian hospitals...
  75. Shields R, Kwak E, Potoski B, Doi Y, Adams Haduch J, Silviera F, et al. High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective trea. Diagn Microbiol Infect Dis. 2011;70:246-52 pubmed publisher
    ..Subsequently, 80% (4/5) of transplant patients were treated successfully with carbepenem-colistin regimens...
  76. Carrër A, Poirel L, Yilmaz M, Akan O, Feriha C, Cuzon G, et al. Spread of OXA-48-encoding plasmid in Turkey and beyond. Antimicrob Agents Chemother. 2010;54:1369-73 pubmed publisher
    ..That gene was located within either transposon Tn1999 or transposon Tn1999.2, which was always inserted within the same gene. This work highlights the current plasmid-mediated dissemination of the OXA-48 carbapenemase worldwide...
  77. Neonakis I, Samonis G, Messaritakis H, Baritaki S, Georgiladakis A, Maraki S, et al. Resistance status and evolution trends of Klebsiella pneumoniae isolates in a university hospital in Greece: ineffectiveness of carbapenems and increasing resistance to colistin. Chemotherapy. 2010;56:448-52 pubmed publisher
    ..Due to its increased non-susceptibility rates, Klebsiella pneumoniae has emerged as one of the most problematic pathogens...
  78. Fu Y, Zhou J, Zhou H, Yang Q, Wei Z, Yu Y, et al. Wide dissemination of OXA-23-producing carbapenem-resistant Acinetobacter baumannii clonal complex 22 in multiple cities of China. J Antimicrob Chemother. 2010;65:644-50 pubmed publisher
    ..In this study, multilocus sequence typing (MLST) was used to describe the genetic backgrounds of carbapenem-resistant Acinetobacter baumannii (CRAB) and carbapenem-susceptible A. baumannii (CSAB) from multiple cities of China...
  79. Chen S, Hu F, Liu Y, Zhu D, Wang H, Zhang Y. Detection and spread of carbapenem-resistant Citrobacter freundii in a teaching hospital in China. Am J Infect Control. 2011;39:e55-60 pubmed publisher
    ..We examined the detection and spread of carbapenem-resistant Citrobacter freundii in Huashan Hospital, Shanghai, China between 2005 and 2008...
  80. Dubée V, Triboulet S, Mainardi J, Etheve Quelquejeu M, Gutmann L, Marie A, et al. Inactivation of Mycobacterium tuberculosis l,d-transpeptidase LdtMt? by carbapenems and cephalosporins. Antimicrob Agents Chemother. 2012;56:4189-95 pubmed publisher
    ..b>Carbapenems inactivate these l,d-transpeptidases, and meropenem combined with clavulanic acid is bactericidal against ..
  81. Canton R, Akova M, Carmeli Y, Giske C, Glupczynski Y, Gniadkowski M, et al. Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. Clin Microbiol Infect. 2012;18:413-31 pubmed publisher
    ..Although their hydrolysis spectrum may vary, they hydrolyse most ?-lactams, including carbapenems. They are mostly of the KPC, VIM, NDM and OXA-48 types...
  82. Mammeri H, Guillon H, Eb F, Nordmann P. Phenotypic and biochemical comparison of the carbapenem-hydrolyzing activities of five plasmid-borne AmpC ?-lactamases. Antimicrob Agents Chemother. 2010;54:4556-60 pubmed publisher
    ..Therefore, CMY-2-type, ACT-1-type, and DHA-1-type ?-lactamases may promote the emergence of carbapenem resistance in porin-deficient clinical isolates...