beta lactams


Summary: Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.

Top Publications

  1. Zapun A, Contreras Martel C, Vernet T. Penicillin-binding proteins and beta-lactam resistance. FEMS Microbiol Rev. 2008;32:361-85 pubmed publisher
  2. Petrella S, Ziental Gelus N, Mayer C, Renard M, Jarlier V, Sougakoff W. Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. Antimicrob Agents Chemother. 2008;52:3725-36 pubmed publisher
  3. Woodford N, Zhang J, Warner M, Kaufmann M, Matos J, MacDonald A, et al. Arrival of Klebsiella pneumoniae producing KPC carbapenemase in the United Kingdom. J Antimicrob Chemother. 2008;62:1261-4 pubmed publisher
    ..KPC-type carbapenemases are increasingly prevalent in parts of the USA and Israel and are an emerging concern in South America, Europe and China. We investigated the UK's first two KPC-producing Klebsiella pneumoniae isolates...
  4. Peirano G, Seki L, Val Passos V, Pinto M, Guerra L, Asensi M. Carbapenem-hydrolysing beta-lactamase KPC-2 in Klebsiella pneumoniae isolated in Rio de Janeiro, Brazil. J Antimicrob Chemother. 2009;63:265-8 pubmed publisher
    ..The aim of this study was to characterize the KPC-type carbapenem-hydrolysing beta-lactamase, extended-spectrum beta-lactamases (ESBLs) and class 1 integrons among nosocomial Klebsiella pneumoniae isolated in Rio de Janeiro, Brazil...
  5. Livermore D, Mushtaq S, Warner M, Miossec C, Woodford N. NXL104 combinations versus Enterobacteriaceae with CTX-M extended-spectrum beta-lactamases and carbapenemases. J Antimicrob Chemother. 2008;62:1053-6 pubmed publisher
    ..We examined whether combinations of oxyimino-cephalosporins with NXL104, a novel non-beta-lactam beta-lactamase inhibitor, overcame these resistances...
  6. Burkhardt O, Brunner M, Schmidt S, Grant M, Tang Y, Derendorf H. Penetration of ertapenem into skeletal muscle and subcutaneous adipose tissue in healthy volunteers measured by in vivo microdialysis. J Antimicrob Chemother. 2006;58:632-6 pubmed
    ..The present microdialysis study was conducted to measure free, protein-unbound ertapenem concentrations in muscle and subcutaneous tissue...
  7. Betriu C, Salso S, Sánchez A, Culebras E, Gomez M, Rodriguez Avial I, et al. Comparative in vitro activity and the inoculum effect of ertapenem against Enterobacteriaceae resistant to extended-spectrum cephalosporins. Int J Antimicrob Agents. 2006;28:1-5 pubmed
    ..The data from this study suggest that this new carbapenem may be useful for treating mixed infections involving Enterobacteriaceae isolates resistant to third-generation cephalosporins...
  8. Sauvage E, Kerff F, Terrak M, Ayala J, Charlier P. The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis. FEMS Microbiol Rev. 2008;32:234-58 pubmed publisher
    ..An overview of the content in PBPs of some bacteria is provided with an emphasis on comparing the biochemical properties of homologous PBPs (orthologues) belonging to different bacteria...
  9. Lodise T, Lomaestro B, Drusano G. Piperacillin-tazobactam for Pseudomonas aeruginosa infection: clinical implications of an extended-infusion dosing strategy. Clin Infect Dis. 2007;44:357-63 pubmed
    ..This study evaluates the clinical implications of extended infusion of piperacillin-tazobactam therapy for critically ill patients with P. aeruginosa infection...

More Information


  1. Chatterjee I, Iredell J, Woods M, Lipman J. The implications of enterococci for the intensive care unit. Crit Care Resusc. 2007;9:69-75 pubmed
    ..To review the evidence of pathogenicity and virulence of Enterococcus spp. in the intensive care unit...
  2. Kress C, Seidler C, Kerp B, Schneider E, Usleber E. Experiences with an identification and quantification program for inhibitor-positive milk samples. Anal Chim Acta. 2007;586:275-9 pubmed
    ..3%), isoxazolyl penicillins (3.2%), and sulfonamides (1.6%). The results indicate that penicillin G is still the predominant antibiotic responsible for violative bulk tank milk samples as detected during regulatory control...
  3. Lipsky B, Sheehan P, Armstrong D, Tice A, Polis A, Abramson M. Clinical predictors of treatment failure for diabetic foot infections: data from a prospective trial. Int Wound J. 2007;4:30-8 pubmed
    ..Increased white blood cell count and severe UT wound grade at baseline, but not other features, were significant independent and additive risk factors for clinical failure in patients treated for a diabetic foot infection...
  4. Hawkey P. Prevalence and clonality of extended-spectrum beta-lactamases in Asia. Clin Microbiol Infect. 2008;14 Suppl 1:159-65 pubmed
    ..The high prevalence of ESBL genes in Asia means that the empirical treatment of serious infections with beta-lactam antibiotics, except carbapenems, is seriously compromised...
  5. DeRyke C, Kuti J, Nicolau D. Pharmacodynamic target attainment of six beta-lactams and two fluoroquinolones against Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, and Klebsiella species collected from United States intensive care units in 2004. Pharmacotherapy. 2007;27:333-42 pubmed
    ..To determine the likelihood that antibiotic regimens achieve bactericidal pharmacodynamic exposures against common nosocomial pathogens...
  6. Namias N, Solomkin J, Jensen E, Tomassini J, Abramson M. Randomized, multicenter, double-blind study of efficacy, safety, and tolerability of intravenous ertapenem versus piperacillin/tazobactam in treatment of complicated intra-abdominal infections in hospitalized adults. Surg Infect (Larchmt). 2007;8:15-28 pubmed
    ..Complicated intra-abdominal infections are a common problem in surgical practice. This study compared the effectiveness of ertapenem (1 g qd) and piperacillin/tazobactam (3.375 g q6h) in the treatment of these infections...
  7. Falagas M, Peppas G, Makris G, Karageorgopoulos D, Matthaiou D. Meta-analysis: ertapenem for complicated intra-abdominal infections. Aliment Pharmacol Ther. 2008;27:919-31 pubmed publisher
    ..Ertapenem is a new member of the carbapenem class of antibiotics, with a favourable pharmacokinetic profile, but a narrower spectrum of antimicrobial activity, compared with older representatives of this class...
  8. Lemaire S, Fuda C, Van Bambeke F, Tulkens P, Mobashery S. Restoration of susceptibility of methicillin-resistant Staphylococcus aureus to beta-lactam antibiotics by acidic pH: role of penicillin-binding protein PBP 2a. J Biol Chem. 2008;283:12769-76 pubmed publisher
  9. Lamar J, Petz M. Development of a receptor-based microplate assay for the detection of beta-lactam antibiotics in different food matrices. Anal Chim Acta. 2007;586:296-303 pubmed
    ..Matrix calibration curves are presented, which show that quantitative analyses are possible...
  10. DeRyke C, Banevicius M, Fan H, Nicolau D. Bactericidal activities of meropenem and ertapenem against extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a neutropenic mouse thigh model. Antimicrob Agents Chemother. 2007;51:1481-6 pubmed
    ..However, for isolates with raised ertapenem MICs of>or=2 microg/ml, meropenem displayed sustained efficacy due to its greater in vitro potency and higher resultant fT>MIC...
  11. Paull D, Abraham C, Scerba M, Alden Danforth E, Lectka T. Bifunctional asymmetric catalysis: cooperative Lewis acid/base systems. Acc Chem Res. 2008;41:655-63 pubmed publisher
    ..To place our results in perspective, many important contributions to this emerging field are highlighted and our own reports are chronicled...
  12. Naas T, Cuzon G, Villegas M, Lartigue M, Quinn J, Nordmann P. Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene. Antimicrob Agents Chemother. 2008;52:1257-63 pubmed publisher
    ..Tn4401 is likely at the origin of carbapenem-hydrolyzing beta-lactamase KPC mobilization to plasmids and its further insertion into various-sized plasmids identified in nonclonally related K. pneumoniae and P. aeruginosa isolates...
  13. Boselli E, Breilh D, Djabarouti S, Bel J, Saux M, Allaouchiche B. Diffusion of ertapenem into bone and synovial tissues. J Antimicrob Chemother. 2007;60:893-6 pubmed
    ..However, no studies concerning its diffusion into bone and synovial tissue are available. Our objective was to quantify ertapenem bone and synovial tissue penetration and to compare our data with the MIC(90)s for causative pathogens...
  14. Tice A, Turpin R, Hoey C, Lipsky B, Wu J, Abramson M. Comparative costs of ertapenem and piperacillin-tazobactam in the treatment of diabetic foot infections. Am J Health Syst Pharm. 2007;64:1080-6 pubmed
    ..To evaluate potential cost savings, trial data were used to determine the clinical outcomes for i.v. ertapenem given once daily and i.v. piperacillin-tazobactam given every six hours daily in treating diabetic foot infections...
  15. Bush K, Jacoby G. Updated functional classification of beta-lactamases. Antimicrob Agents Chemother. 2010;54:969-76 pubmed publisher
  16. Sakata H. [T serotypes distribution and antimicrobial susceptibility of Streptococcus pyogenes in children with pharyngotonsillitis in Asahikawa]. Jpn J Antibiot. 2008;61:359-65 pubmed
    ..008 microg/ml in penicillin G, cefcapene, cefditoren, cefteram, cefdinir and faropenem, and 0.015 microg/ml in amoxicillin. Of 367 isolates, macrolide-resistant (erythromycin > 0.5 micro/ml) strains account for 42 (11.4%). ..
  17. de Andrade J, de Macêdo Farias L, Ferreira J, Bruna Romero O, da Glória de Souza D, de Carvalho M, et al. Sub-Inhibitory Concentration of Piperacillin-Tazobactam May be Related to Virulence Properties of Filamentous Escherichia coli. Curr Microbiol. 2016;72:19-28 pubmed publisher
    ..coli in the murine model of intra-abdominal infection. In other words, the treatment of E. coli with sub-MIC of PTZ suggests a decrease in their virulence. ..
  18. Leavitt A, Chmelnitsky I, Colodner R, Ofek I, Carmeli Y, Navon Venezia S. Ertapenem resistance among extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae isolates. J Clin Microbiol. 2009;47:969-74 pubmed publisher
    ..These rare resistant subpopulations carried multiple ESBL genes, including TEM-30, SHV-44, CTX-M-2, and CTX-M-10, and they lacked OMPK36. The clinical and diagnostic significance of the results should be further studied. ..
  19. Cattoir V, Daurel C. [Update on antimicrobial chemotherapy]. Med Mal Infect. 2010;40:135-54 pubmed publisher
    ..e. ceftobiprole, ceftaroline, dalbavancin, telavancin, oritavancin, iclaprim, and ramoplanin) or available in other countries (i.e. garenoxacin, sitafloxacin, and temocillin). ..
  20. Raup D, Cardinal David B, Holte D, Scheidt K. Cooperative catalysis by carbenes and Lewis acids in a highly stereoselective route to gamma-lactams. Nat Chem. 2010;2:766-71 pubmed publisher
  21. Ahsman M, Wildschut E, Tibboel D, Mathot R. Microanalysis of beta-lactam antibiotics and vancomycin in plasma for pharmacokinetic studies in neonates. Antimicrob Agents Chemother. 2009;53:75-80 pubmed publisher
    ..Using ultra-performance liquid chromatography mass spectrometry, this method allows simple and reliable quantification of multiple antibiotics in 50 microl of plasma for PK studies of neonates. ..
  22. Rodríguez Varón A, Muñoz O, Pulido Arenas J, Amado S, Tobón Trujillo M. Antibiotic-associated diarrhea: Clinical characteristics and the presence of Clostridium difficile. Rev Gastroenterol Mex. 2017;82:129-133 pubmed publisher
    ..The presence of Clostridium difficile in only 13.9% of the cases suggests that other causes of diarrhea in the hospitalized patient should be considered. ..
  23. Kumar G, Biswal S, Nathan S, Ghosh A. Glutamate residues at positions 162nd and 164th influence the beta-lactamase activity of SHV-14 obtained from Klebsiella pneumoniae. FEMS Microbiol Lett. 2017;: pubmed publisher
  24. Davodian E, Sadeghifard N, Ghasemian A, Noorbakhsh S. Presence of blaPER-1 and blaVEB-1 beta-lactamase genes among isolates of Pseudomonas aeruginosa from South West of Iran. J Epidemiol Glob Health. 2016;6:211-3 pubmed publisher
    ..Ten (15.3%) isolates were ESBL-positive, of which 40% (n=4) belonged to males and 60% (n=6) were collected from females. Moreover, two and one isolates harbored blaPER-1 and blaVEB-1 genes, respectively. ..
  25. Lee D, Kim Y, Lee M, Ahn C, Jung W, Je J. Synergistic effects between aminoethyl-chitosans and beta-lactams against methicillin-resistant Staphylococcus aureus (MRSA). Bioorg Med Chem Lett. 2010;20:975-8 pubmed publisher
    ..When AECs and beta-lactams were combined, synergistic effects were observed with fractional inhibitory concentration (FIC) indices of 0.252-0.508, and the MICs of beta-lactams in the presence of AECs were dramatically reduced. ..
  26. Barberán J, Mensa J, Farinas C, Llinares P, Olaechea P, Palomar M, et al. [Recommendations of antimicrobial treatment in patients allergic to beta-lactam antibiotics]. Rev Esp Quimioter. 2008;21:60-82 pubmed
    ..that are as effective and safe as beta-lactams. In this article we have developed a few recommendations for the management of patients with allergy to beta-lactams on the basis of evidence and expert opinion. ..
  27. Hawser S, Bouchillon S, Hoban D, Badal R, Hsueh P, Paterson D. Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. Antimicrob Agents Chemother. 2009;53:3280-4 pubmed publisher
    ..Quinolones achieved 90% inhibition levels only against ESBL-negative K. pneumoniae and ESBL-negative K. oxytoca. A decline in ampicillin-sulbactam activity was noted, with only 34.5% of all Enterobacteriaceae inhibited in this study. ..
  28. Zahradník J, Plačková M, Palyzová A, Maresová H, Kyslíková E, Kyslík P. Draft Genome Sequence of Pantoea agglomerans JM1, a Strain Isolated from Soil Polluted by Industrial Production of Beta-Lactam Antibiotics That Exhibits Valacyclovir-Like Hydrolase Activity. Genome Announc. 2017;5: pubmed publisher
    ..The bacterium exhibited enzymatic activities useful for the biotransformation of beta-lactams. The genome of the strain was assembled and described, and the gene encoding valacyclovir-like hydrolase was identified. ..
  29. Chu C, Lowder J. Diagnosis and treatment of urinary tract infections across age groups. Am J Obstet Gynecol. 2018;219:40-51 pubmed publisher
    ..Interpreting the probability of urinary tract infection based on symptoms and testing allows for greater accuracy in diagnosis of urinary tract infection, decreasing overtreatment and encouraging antimicrobial stewardship. ..
  30. Shahcheraghi F, Nikbin V, Feizabadi M. Prevalence of ESBLs genes among multidrug-resistant isolates of Pseudomonas aeruginosa isolated from patients in Tehran. Microb Drug Resist. 2009;15:37-9 pubmed publisher
    ..This is the first report on the existence of bla(VEB), and bla(PER) in Iran. Colistin and polymixin B are highly potent against the imipenem-resistant isolates of P. aeruginosa. ..
  31. Ku Y, Chuang Y, Yu W. In vitro activity of tigecycline against clinical isolates of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae, Serratia marcescens and Enterobacter cloacae. J Microbiol Immunol Infect. 2008;41:332-6 pubmed
    ..38 to 0.75 microg/mL and 0.5 to 1.5 microg/mL, respectively. Tigecycline, a new semisynthetic glycylcycline, may be considered an alternative drug of choice for patients infected with ESBL-producing bacteria. ..
  32. Jakowiecki J, Loska R, Makosza M. Synthesis of alpha-trifluoromethyl-beta-lactams and esters of beta-amino acids via 1,3-dipolar cycloaddition of nitrones to fluoroalkenes. J Org Chem. 2008;73:5436-41 pubmed publisher
  33. Muller A, Huttner B, Huttner A. Therapeutic Drug Monitoring of Beta-Lactams and Other Antibiotics in the Intensive Care Unit: Which Agents, Which Patients and Which Infections?. Drugs. 2018;78:439-451 pubmed publisher
  34. Ahuja V, Schreiber C, Platzek T, Stahlmann R. Investigation of the sensitising and cross-sensitising potential of textile dyes and beta-lactam antibiotics using a biphasic mice local lymph node assay. Arch Toxicol. 2009;83:691-9 pubmed publisher
    ..We conclude that a biphasic, modified protocol of the LLNA is a suitable approach to test for a cross-reactivity potential of two related compounds. ..
  35. Costa D, Vinué L, Poeta P, Coelho A, Matos M, Sáenz Y, et al. Prevalence of extended-spectrum beta-lactamase-producing Escherichia coli isolates in faecal samples of broilers. Vet Microbiol. 2009;138:339-44 pubmed publisher
    ..Amino acid changes in GyrA and ParC proteins were identified in all 18 ciprofloxacin-resistant isolates. The results of this study indicate that the intestinal tract of healthy poultry is a reservoir of ESBL-positive E. coli isolates. ..
  36. Dehoux P, Marvaud J, Abouelleil A, Earl A, Lambert T, Dauga C. Comparative genomics of Clostridium bolteae and Clostridium clostridioforme reveals species-specific genomic properties and numerous putative antibiotic resistance determinants. BMC Genomics. 2016;17:819 pubmed
    ..A few of them were related to antibiotics inactive against Clostridium spp. Some were part of mobile genetic elements suggesting that these commensals of the human microbiota act as reservoir of antimicrobial resistances. ..
  37. Suding P, Jensen E, Abramson M, Itani K, Wilson S. Definitive risk factors for anastomotic leaks in elective open colorectal resection. Arch Surg. 2008;143:907-11; discussion 911-2 pubmed publisher
    ..Significant risk factors for anastomotic leaks include low preoperative serum albumin level, steroid use, male sex, and increased duration of surgery. Appreciation of risk factors provides a rational basis for temporary diversion. ..
  38. Kluge A, Petter R. Acylating drugs: redesigning natural covalent inhibitors. Curr Opin Chem Biol. 2010;14:421-7 pubmed publisher
    ..This review provides a perspective on these two classes of acylating agents and summarizes recent advances in mechanism and structure-based design of acylating drugs. ..
  39. Calzi A, Grignolo S, Caviglia I, Calevo M, Losurdo G, Piaggio G, et al. Resistance to oral antibiotics in 4569 Gram-negative rods isolated from urinary tract infection in children. Eur J Pediatr. 2016;175:1219-1225 pubmed publisher
  40. Osińska A, Korzeniewska E, Harnisz M, Niestępski S. The prevalence and characterization of antibiotic-resistant and virulent Escherichia coli strains in the municipal wastewater system and their environmental fate. Sci Total Environ. 2017;577:367-375 pubmed publisher
    ..Multidrug resistance was determined more frequently in strains isolated from DRW than in isolates from URW samples. Our findings provide valuable inputs for evaluating public health hazards associated with bacterial contamination. ..
  41. Adrian J, Pinacho D, Granier B, Diserens J, Sanchez Baeza F, Marco M. A multianalyte ELISA for immunochemical screening of sulfonamide, fluoroquinolone and ss-lactam antibiotics in milk samples using class-selective bioreceptors. Anal Bioanal Chem. 2008;391:1703-12 pubmed publisher
    ..The detectability reached in full-fat milk samples is below the European maximum residue limits. The accuracy and reliability of this multiplexed bioanalytical method have been demonstrated by analyzing blind spiked samples. ..
  42. Yamaguchi Y, Hanaki H, Yanagisawa C, Ikeda Dantsuji Y, Hashimoto T, Yazaki H, et al. Characterization of beta-lactam antibiotic-induced vancomycin-resistant MRSA (BIVR) in a patient with septicemia during long-term vancomycin administration. J Infect Chemother. 2009;15:274-8 pubmed publisher
    ..Our results indicate the possibility that long-term VCM therapy is one of the factors that allow BIVR or VCM-low-sensitive MRSA to emerge, and this allows VCM therapy for MRSA to fail. ..
  43. Danilchanka O, Pavlenok M, Niederweis M. Role of porins for uptake of antibiotics by Mycobacterium smegmatis. Antimicrob Agents Chemother. 2008;52:3127-34 pubmed publisher
    ..avium, M. chelonae, and M. fortuitum, which have Msp-like porins, to acquire resistance to fluoroquinolones...
  44. Katayama Y, Murakami Kuroda H, Cui L, Hiramatsu K. Selection of heterogeneous vancomycin-intermediate Staphylococcus aureus by imipenem. Antimicrob Agents Chemother. 2009;53:3190-6 pubmed publisher
    ..We conclude that exposure not only to VAN but also to beta-lactams may select for reduced glycopeptide susceptibility in S. aureus. ..
  45. Wen Q, Yang L, Duan R, Chen Z. Monitoring and evaluation of antibiotic resistance genes in four municipal wastewater treatment plants in Harbin, Northeast China. Environ Pollut. 2016;212:34-40 pubmed publisher
    ..Although all the WWTPs can remove ARGs effectively, ARGs concentrations are still relatively high in the effluent, their further attenuation should be investigated. ..
  46. Shigemura K, Arakawa S, Yamashita M, Yasufuku T, Fujisawa M. Surgical site infections may be reduced by shorter duration of prophylactic antibiotic medication in urological surgeries. Jpn J Infect Dis. 2009;62:440-3 pubmed
    ..The results indicate that this method might reduce the occurrence of SSI in urological surgeries. ..
  47. Nishino K, Hayashi Nishino M, Yamaguchi A. H-NS modulates multidrug resistance of Salmonella enterica serovar Typhimurium by repressing multidrug efflux genes acrEF. Antimicrob Agents Chemother. 2009;53:3541-3 pubmed publisher
    ..In this study, we report that H-NS modulates multidrug resistance through repression of the genes that encode the AcrEF multidrug efflux pump in Salmonella enterica serovar Typhimurium. ..
  48. Edwards S, Clarke M, Wordsworth S, Welton N. Carbapenems versus other beta-lactams in the treatment of hospitalised patients with infection: a mixed treatment comparison. Curr Med Res Opin. 2009;25:251-61 pubmed
    ..This mixed treatment comparison suggests meropenem has substantial advantages over cefepime, ertapenem, imipenem/cilastatin and piperacillin/tazobactam in the treatment of hospitalised patients with infection. ..
  49. Preinerstorfer B, Schiesel S, Lämmerhofer M, Lindner W. Metabolic profiling of intracellular metabolites in fermentation broths from beta-lactam antibiotics production by liquid chromatography-tandem mass spectrometry methods. J Chromatogr A. 2010;1217:312-28 pubmed publisher
    ..Quantitative results obtained with the different methods agreed well, however, for some analytes external calibration was found to be ill-suited due to matrix effects. ..
  50. Liras P, Demain A. Chapter 16. Enzymology of beta-lactam compounds with cephem structure produced by actinomycete. Methods Enzymol. 2009;458:401-29 pubmed publisher
    ..The cefE gene of S. clavuligerus, encoding DAOCS, has been extensively used to expand the penicillin ring in filamentous fungi in vivo using DNA recombinant technology. ..
  51. Onori R, Gaiarsa S, Comandatore F, Pongolini S, Brisse S, Colombo A, et al. Tracking Nosocomial Klebsiella pneumoniae Infections and Outbreaks by Whole-Genome Analysis: Small-Scale Italian Scenario within a Single Hospital. J Clin Microbiol. 2015;53:2861-8 pubmed publisher
    ..Our work demonstrates how the use of combined phenotypic, molecular, and whole-genome sequencing techniques can help to identify quickly and to characterize accurately the spread of MDR pathogens. ..
  52. Kotsakis S, Papagiannitsis C, Tzelepi E, Legakis N, Miriagou V, Tzouvelekis L. GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2010;54:1331-3 pubmed publisher
    ..GES-13 efficiently hydrolyzed broad-spectrum cephalosporins and aztreonam. Imipenem was a potent inhibitor of GES-13 but was not hydrolyzed at measurable rates. ..
  53. Raymond J, Cohen R. [Bacteriology of cutaneous infections of the child]. Arch Pediatr. 2008;15 Suppl 2:S59-61 pubmed publisher
    ..In France, the incidence of methicillin resistant community acquired S. aureus strains is currently low, around 6 %, but the risk of a rapid increase is real...
  54. Oueslati S, Smaoui H, Joubert G, Dabernat H, Kechrid A. [Beta lactam resistance and molecular markers of 157 Haemophilus influenzae isolates from infants in Tunis]. Can J Microbiol. 2009;55:515-9 pubmed publisher
    ..All H. influenzae strains, including noncapsulated strains and serotype-b encapsulated strains, had a high level of heterogeneity, with diversity indices of respectively 0.67 and 0.94...
  55. Papagiannitsis C, Tzouvelekis L, Miriagou V. Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter. Antimicrob Agents Chemother. 2009;53:277-80 pubmed publisher
    ..Hybrid 2 was stronger than hybrid 1. Coupling P2 with the strong promoter and with hybrid 1 caused a measurable increase in GES-1 expression...
  56. Sauvage E, Powell A, Heilemann J, Josephine H, Charlier P, Davies C, et al. Crystal structures of complexes of bacterial DD-peptidases with peptidoglycan-mimetic ligands: the substrate specificity puzzle. J Mol Biol. 2008;381:383-93 pubmed publisher
    ..This striking deficiency may represent a sophisticated defense mechanism against low-molecular-mass substrate-analogue inhibitors/antibiotics; its discovery should focus new inhibitor design...
  57. Ridella M, Bagdure S, Nugent K, Cevik C. Kounis syndrome following beta-lactam antibiotic use: review of literature. Inflamm Allergy Drug Targets. 2009;8:11-6 pubmed
    ..Patients with anaphylaxis can have acute coronary syndromes secondary to allergic mediator effects on coronary vessels. Information about these cases is restricted to isolated case reports...
  58. Chung H, Yao Z, Goehring N, Kishony R, Beckwith J, Kahne D. Rapid beta-lactam-induced lysis requires successful assembly of the cell division machinery. Proc Natl Acad Sci U S A. 2009;106:21872-7 pubmed publisher
    ..One seemingly paradoxical implication of our results is that beta-lactam therapy may be improved by promoting active cell division. ..
  59. Moriyama B, Henning S, Childs R, Holland S, Anderson V, Morris J, et al. High-dose continuous infusion beta-lactam antibiotics for the treatment of resistant Pseudomonas aeruginosa infections in immunocompromised patients. Ann Pharmacother. 2010;44:929-35 pubmed publisher
    ..aeruginosa infections in 3 chronically immunocompromised patients. Continuous infusion beta-lactam antibiotics are a potentially useful treatment strategy for resistant P. aeruginosa infections in immunocompromised patients. ..
  60. Robin F, Aggoune Khinache N, Delmas J, Naim M, Bonnet R. Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. Antimicrob Agents Chemother. 2010;54:466-70 pubmed publisher
    ..VIM-19 is the first carbapenemase enzyme identified from an isolate from Algeria. These results confirm the emergence of VIM-4-like enzymes in members of the family Enterobacteriaceae from Mediterranean countries...
  61. Staub I, Sieber S. Beta-lactam probes as selective chemical-proteomic tools for the identification and functional characterization of resistance associated enzymes in MRSA. J Am Chem Soc. 2009;131:6271-6 pubmed publisher
  62. McWhinney B, Wallis S, Hillister T, Roberts J, Lipman J, Ungerer J. Analysis of 12 beta-lactam antibiotics in human plasma by HPLC with ultraviolet detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878:2039-43 pubmed publisher
    ..Validation has demonstrated the method to be linear, accurate and precise. The method has been used in a pathology laboratory for therapeutic drug monitoring (TDM) of beta-lactams in critically ill patients...
  63. Delattre I, Musuamba F, Verbeeck R, Dugernier T, Spapen H, Laterre P, et al. Empirical models for dosage optimization of four beta-lactams in critically ill septic patients based on therapeutic drug monitoring of amikacin. Clin Biochem. 2010;43:589-98 pubmed publisher
    ..The study aims to develop empirical models able to predict the pharmacokinetics (PK) of four beta-lactams using the amikacin (AMK) therapeutic drug monitoring (TDM), in order to optimize their dosage regimens...
  64. Abrahamian F, DeBlieux P, Emerman C, Kollef M, Kupersmith E, Leeper K, et al. Health care-associated pneumonia: identification and initial management in the ED. Am J Emerg Med. 2008;26:1-11 pubmed publisher
    ..The aim of this article is to create awareness of the entity known as HCAP and to provide knowledge of its identification and initial management in the emergency department...
  65. Randall L, Kirchner M, Teale C, Coldham N, Liebana E, Clifton Hadley F. Evaluation of CHROMagar CTX, a novel medium for isolating CTX-M-ESBL-positive Enterobacteriaceae while inhibiting AmpC-producing strains. J Antimicrob Chemother. 2009;63:302-8 pubmed publisher
    ..The aim of this study was to evaluate CHROMagar CTX (CHROMagar France), a novel agar for the selective isolation of Enterobacteriaceae expressing the bla(CTX-M) gene in the presence of enteric bacteria expressing AmpC enzymes...
  66. Roberts J, Webb S, Paterson D, Ho K, Lipman J. A systematic review on clinical benefits of continuous administration of beta-lactam antibiotics. Crit Care Med. 2009;37:2071-8 pubmed publisher
    ..We systematically reviewed the literature to determine whether any clinical benefits exist for administration of beta-lactam antibiotics by extended or continuous infusion...
  67. Zhao S, Blickenstaff K, Glenn A, Ayers S, Friedman S, Abbott J, et al. beta-Lactam resistance in salmonella strains isolated from retail meats in the United States by the National Antimicrobial Resistance Monitoring System between 2002 and 2006. Appl Environ Microbiol. 2009;75:7624-30 pubmed publisher
  68. Sorlozano A, Carrasco C, Cabeza J, Villegas E, Gutierrez J. Antimicrobial development in the era of emerging resistance. Mini Rev Med Chem. 2009;9:938-55 pubmed
    ..Moreover, all of them would be useful for skin and soft tissue infections...
  69. Kawai F, Clarke T, Roper D, Han G, Hwang K, Unzai S, et al. Crystal structures of penicillin-binding proteins 4 and 5 from Haemophilus influenzae. J Mol Biol. 2010;396:634-45 pubmed publisher
    ..The ready inhibition of PBP4 by beta-lactams compared to PBP5 also appears to be related to the weaker interactions holding key residues in a catalytically competent position...
  70. Badarau A, Page M. Loss of enzyme activity during turnover of the Bacillus cereus beta-lactamase catalysed hydrolysis of beta-lactams due to loss of zinc ion. J Biol Inorg Chem. 2008;13:919-28 pubmed publisher
  71. Erac B, Tasli H, Ermertcan S, Cilli F, Limoncu M. [In vitro activity of linezolid/ertapenem combination in resistant gram-positive bacteria]. Mikrobiyol Bul. 2009;43:45-51 pubmed
    ..Although these results support the use of linezolid/ertapenem combination in infections caused by resistant gram-positive strains, further in vitro and in vivo studies are necessary...
  72. Brink A, Richards G, Schillack V, Kiem S, Schentag J. Pharmacokinetics of once-daily dosing of ertapenem in critically ill patients with severe sepsis. Int J Antimicrob Agents. 2009;33:432-6 pubmed publisher
    ..This raises the question as to whether ertapenem is an appropriate agent for initial use in critically ill patients with severe sepsis...
  73. Jacquin O, Balbeur D, Damblon C, Marchot P, De Pauw E, Roberts G, et al. Positively cooperative binding of zinc ions to Bacillus cereus 569/H/9 beta-lactamase II suggests that the binuclear enzyme is the only relevant form for catalysis. J Mol Biol. 2009;392:1278-91 pubmed publisher
  74. Jacoby G. AmpC beta-lactamases. Clin Microbiol Rev. 2009;22:161-82, Table of Contents pubmed publisher
  75. Long D, Aggen J, Christensen B, Judice J, Hegde S, Kaniga K, et al. A multivalent approach to drug discovery for novel antibiotics. J Antibiot (Tokyo). 2008;61:595-602 pubmed publisher
    ..Compound 8e demonstrated excellent bactericidal activity against MRSA (ATCC 33591) and initial evidence supports a multivalent mechanism of action for this important new class of antibiotic...
  76. Tsakris A, Kristo I, Poulou A, Themeli Digalaki K, Ikonomidis A, Petropoulou D, et al. Evaluation of boronic acid disk tests for differentiating KPC-possessing Klebsiella pneumoniae isolates in the clinical laboratory. J Clin Microbiol. 2009;47:362-7 pubmed publisher
    ..3%). These practical and simple boronic acid disk tests promise to be very helpful for the accurate differentiation of KPC-possessing K. pneumoniae isolates, even in regions where different broad-spectrum beta-lactamases are widespread...
  77. Okamura M, Terada T, Katsura T, Inui K. Inhibitory effect of zinc on the absorption of beta-lactam antibiotic ceftibuten via the peptide transporters in rats. Drug Metab Pharmacokinet. 2008;23:464-8 pubmed
    ..The in situ loop technique revealed 50% inhibition of ceftibuten absorption by zinc. In conclusion, zinc inhibits the transport activity of PEPT1 in vivo as well in vitro...
  78. Dracea O, Iordache C, Bucur M, Bleotu C, Banu O, Ungureanu C, et al. Investigation of the influence of different physico-chemical parameters upon the susceptibility of planktonic and adherent Escherichia coli cells to beta-lactams and quinolones. Roum Arch Microbiol Immunol. 2009;68:50-4 pubmed
  79. Nicola G, Tomberg J, Pratt R, Nicholas R, Davies C. Crystal structures of covalent complexes of ?-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity. Biochemistry. 2010;49:8094-104 pubmed publisher
    ..Because the ring nitrogen occupies a similar position in all three complexes, this supports the hypothesis that deacylation is blocked by the continued presence of the leaving group after opening of the ?-lactam ring...
  80. Shah N, Osmon D, Fadel H, Patel R, Kohner P, Steckelberg J, et al. Laboratory and clinical characteristics of Staphylococcus lugdunensis prosthetic joint infections. J Clin Microbiol. 2010;48:1600-3 pubmed publisher
    ..The majority of the isolates lacked mecA. Episodes treated with a parenteral beta-lactam antibiotic appear to have a more favorable outcome than those treated with parenteral vancomycin...
  81. Suarez C, Gudiol F. [Beta-lactam antibiotics]. Enferm Infecc Microbiol Clin. 2009;27:116-29 pubmed publisher
  82. Svetitsky S, Leibovici L, Paul M. Comparative efficacy and safety of vancomycin versus teicoplanin: systematic review and meta-analysis. Antimicrob Agents Chemother. 2009;53:4069-79 pubmed publisher
    ..44; 95% CI, 0.32 to 0.61), and red man syndrome were significantly less frequent with teicoplanin. Teicoplanin is not inferior to vancomycin with regard to efficacy and is associated with a lower adverse event rate than vancomycin...
  83. Boutoille D, Jacqueline C, Le Mabecque V, Potel G, Caillon J. In vivo impact of the MexAB-OprM efflux system on beta-lactam efficacy in an experimental model of Pseudomonas aeruginosa infection. Int J Antimicrob Agents. 2009;33:417-20 pubmed publisher
    ..In the most difficult-to-treat infections due to P. aeruginosa exhibiting the efflux system MexAB-OprM, CFZ at high doses and by continuous infusion should be preferred to TIC and PIP/TAZ...
  84. Hu Z, Zhao W. Identification of plasmid- and integron-borne blaIMP-1 and blaIMP-10 in clinical isolates of Serratia marcescens. J Med Microbiol. 2009;58:217-21 pubmed publisher
  85. Aizpurua J, Palomo C, Fratila R, Ferrón P, Benito A, Gomez Bengoa E, et al. Mechanistic insights on the magnesium(II) ion-activated reduction of methyl benzoylformate with chelated NADH peptide beta-lactam models. J Org Chem. 2009;74:6691-702 pubmed publisher
  86. Tattevin P, Basuino L, Chambers H. Subinhibitory fluoroquinolone exposure selects for reduced beta-lactam susceptibility in methicillin-resistant Staphylococcus aureus and alterations in the SOS-mediated response. Res Microbiol. 2009;160:187-92 pubmed publisher
    ..In conclusion, sublethal exposure to FQ alters the SOS response in CA-MRSA and selects in a non-lethal manner for stable mutants with enhanced expression of methicillin resistance...
  87. Danilchanka O, Mailaender C, Niederweis M. Identification of a novel multidrug efflux pump of Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2008;52:2503-11 pubmed publisher
    ..Both effects were abrogated in the presence of the efflux pump inhibitor reserpine. These results demonstrate that Rv0194 is a novel multidrug efflux pump of M. tuberculosis...
  88. Van Bambeke F, Tulkens P. [Pharmacodynamics of antibiotics in CSF: principles and consequences (predictive factors of efficacy)]. Med Mal Infect. 2009;39:483-92 pubmed publisher
    ..Other molecules in clinical development are being evaluated for this indication...
  89. Kantiani L, Farré M, Sibum M, Postigo C, Lopez de Alda M, Barcelo D. Fully automated analysis of beta-lactams in bovine milk by online solid phase extraction-liquid chromatography-electrospray-tandem mass spectrometry. Anal Chem. 2009;81:4285-95 pubmed publisher
    ..Because of all these characteristics, the proposed method is applicable and could be deemed necessary within the field of food control and safety...
  90. Gil Navarro M, Muñoz Corte R, Herrero Romero M, Santos Rubio M, Cordero Matía E, Bautista Paloma J. [Work of a multidisciplinary team in the control of the prescription of ertapenem]. Farm Hosp. 2009;33:48-52 pubmed
    ..To determine the effectiveness of the intervention of a multidiscipline antimicrobial control group in the correct prescription of Ertapenem...
  91. Bazan J, Martin S, Kaye K. Newer beta-lactam antibiotics: doripenem, ceftobiprole, ceftaroline, and cefepime. Infect Dis Clin North Am. 2009;23:983-96, ix pubmed publisher
    ..The article also reviews recent data suggesting increased overall mortality with Cefepime (Maxipime) use compared with other beta-lactam antibiotics and the potential risk for neurotoxicity in the setting of renal failure...