sulpiride

Summary

Summary: A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)

Top Publications

  1. Mohamed G, Soliman M. Synthesis, spectroscopic and thermal characterization of sulpiride complexes of iron, manganese, copper, cobalt, nickel, and zinc salts. Antibacterial and antifungal activity. Spectrochim Acta A Mol Biomol Spectrosc. 2010;76:341-7 pubmed publisher
    b>Sulpiride (SPR; L) is a substituted benzamide antipsychotic which is reported to be a selective antagonist of central dopamine receptors and claimed to have mood-elevating properties...
  2. Muller Vahl K. [The benzamides tiapride, sulpiride, and amisulpride in treatment for Tourette's syndrome]. Nervenarzt. 2007;78:264, 266-8, 270-1 pubmed
    ..In adults, other dopamine receptor antagonists such as risperidone, pimozide, and sulpiride seem to be more effective than tiapride...
  3. De Leo V, Morgante G, Musacchio M, Faldini E, Delia A, Petraglia F. The safety of veralipride. Expert Opin Drug Saf. 2006;5:695-701 pubmed
    ..An association between adverse effects and mistake of administration has been described. This article discusses available data on the benefits and risks of veralipride therapy for menopausal symptoms...
  4. Parikh T, Bommana M, Squillante E. Efficacy of surface charge in targeting pegylated nanoparticles of sulpiride to the brain. Eur J Pharm Biopharm. 2010;74:442-50 pubmed publisher
    The objective of the study was to formulate sulpiride-loaded nanoparticles (NPs) that can improve bioretention and achieve dose reduction by passively targeting the drug near the site of action...
  5. Stuchlik A, Rehakova L, Rambousek L, Svoboda J, Vales K. Manipulation of D2 receptors with quinpirole and sulpiride affects locomotor activity before spatial behavior of rats in an active place avoidance task. Neurosci Res. 2007;58:133-9 pubmed
    ..D2 receptor agonist quinpirole and antagonist sulpiride were administered intraperitoneally 20min prior to behavioral testing...
  6. Isbister G, Balit C, MacLeod D, Duffull S. Amisulpride overdose is frequently associated with QT prolongation and torsades de pointes. J Clin Psychopharmacol. 2010;30:391-5 pubmed publisher
    ..Amisulpride overdose commonly causes QT prolongation, bradycardia, and hypotension. Torsades de pointes occurred commonly enough to suggest that amisulpride is highly cardiotoxic in overdose...
  7. Naguib I, Abdelkawy M. Development and validation of stability indicating HPLC and HPTLC methods for determination of sulpiride and mebeverine hydrochloride in combination. Eur J Med Chem. 2010;45:3719-25 pubmed publisher
    ..and highly selective stability indicating methods are adopted for simultaneous quantitative determination of sulpiride and mebeverine hydrochloride in presence of their reported impurities and hydrolytic degradates whether in pure ..
  8. Montemurro D, Rossi G. Veralipride-induced acute coronary syndrome unmasking a non-secreting pheochromocytoma. J Endocrinol Invest. 2006;29:650-2 pubmed
    ..Therefore, this is the first case reporting on veralipride unmasking a silent pheochromocytoma...
  9. Lai E, Chang C, Kao Yang Y, Lin S, Lin C. Effectiveness of sulpiride in adult patients with schizophrenia. Schizophr Bull. 2013;39:673-83 pubmed publisher
    The objective of this study is to compare the effectiveness among sulpiride, risperidone, olanzapine, and haloperidol by evaluating the persistence of drug use...

More Information

Publications72

  1. Becker S, Ceko M, Louis Foster M, Elfassy N, Leyton M, Shir Y, et al. Dopamine and pain sensitivity: neither sulpiride nor acute phenylalanine and tyrosine depletion have effects on thermal pain sensations in healthy volunteers. PLoS ONE. 2013;8:e80766 pubmed publisher
    ..ingested, in separate sessions, a placebo and a low dose of the centrally acting D2-receptor antagonist sulpiride, intended to increase synaptic dopamine via predominant pre-synaptic blockade...
  2. McCabe C, Huber A, Harmer C, Cowen P. The D2 antagonist sulpiride modulates the neural processing of both rewarding and aversive stimuli in healthy volunteers. Psychopharmacology (Berl). 2011;217:271-8 pubmed publisher
    ..We have developed a functional magnetic resonance imaging (fMRI) model which permits examination of the neural processing of both rewarding and aversive stimuli...
  3. Chitneni M, Peh K, Darwis D, Abdulkarim M, Abdullah G, Qureshi M. Intestinal permeability studies of sulpiride incorporated into self-microemulsifying drug delivery system (SMEDDS). Pak J Pharm Sci. 2011;24:113-21 pubmed
    The objective of the present study was to determine the intestinal absorption of sulpiride incorporated into SMEDDS by means of single-pass intestinal perfusion method (SPIP) in rat and to compare the effective permeability coefficient ..
  4. Lapirot O, Melin C, Modolo A, Nicolas C, Messaoudi Y, Monconduit L, et al. Tonic and phasic descending dopaminergic controls of nociceptive transmission in the medullary dorsal horn. Pain. 2011;152:1821-31 pubmed publisher
  5. Lopez Gonzalez M, Moliner Peiro F, Alfaro Garcia J, Esteban Ortega F. Sulpiride plus hydroxyzine decrease tinnitus perception. Auris Nasus Larynx. 2007;34:23-7 pubmed
    The aim of the study is to confirm the effectiveness of sulpiride and hydroxyzine in tinnitus patients...
  6. Pakdel R, Rashidy Pour A. Microinjections of the dopamine D2 receptor antagonist sulpiride into the medial prefrontal cortex attenuate glucocorticoid-induced impairment of long-term memory retrieval in rats. Neurobiol Learn Mem. 2007;87:385-90 pubmed
    ..Bilateral microinjections of the DA D2 receptor antagonist sulpiride (10 or 100 ng/0...
  7. Abbas A, Hedlund P, Huang X, Tran T, Meltzer H, Roth B. Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo. Psychopharmacology (Berl). 2009;205:119-28 pubmed publisher
  8. Lee H, Kim K, Park S, Kim E. Cellular mechanism of the QT prolongation induced by sulpiride. Int J Toxicol. 2009;28:207-12 pubmed publisher
    In this study, the authors investigated the electrophysiological effect of sulpiride on cardiac repolarization using conventional microelectrode recording techniques in isolated canine Purkinje fibers and a whole-cell patch clamp ..
  9. Mehta M, Montgomery A, Kitamura Y, Grasby P. Dopamine D2 receptor occupancy levels of acute sulpiride challenges that produce working memory and learning impairments in healthy volunteers. Psychopharmacology (Berl). 2008;196:157-65 pubmed
    ..DA receptor occupancy could clearly contribute to the variance in findings, although this is typically not known...
  10. Pezze M, Dalley J, Robbins T. Remediation of attentional dysfunction in rats with lesions of the medial prefrontal cortex by intra-accumbens administration of the dopamine D(2/3) receptor antagonist sulpiride. Psychopharmacology (Berl). 2009;202:307-13 pubmed publisher
    ..The prefrontal cortex (PFC) and nucleus accumbens (NAC) are key brain loci considered to mediate many of the cognitive deficits associated with schizophrenia and related disorders...
  11. Dong E, Nelson M, Grayson D, Costa E, Guidotti A. Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation. Proc Natl Acad Sci U S A. 2008;105:13614-9 pubmed publisher
    ..Clinically relevant doses of clozapine (CLZ) (3.8 to 15 micromol/kg twice a day s.c. for 3 days) and sulpiride (SULP) (12.5 to 50 micromol/kg twice a day for 3 days) but not clinically relevant doses of haloperidol (HAL) (1...
  12. Dodds C, Clark L, Dove A, Regenthal R, Baumann F, Bullmore E, et al. The dopamine D2 receptor antagonist sulpiride modulates striatal BOLD signal during the manipulation of information in working memory. Psychopharmacology (Berl). 2009;207:35-45 pubmed publisher
    ..Dopamine (DA) plays an important role in working memory. However, the precise functions supported by different DA receptor subtypes in different neural regions remain unclear...
  13. Ho C, Chen H, Chiu N, Shen E, Lue H. Short-term sulpiride treatment of children and adolescents with Tourette syndrome or chronic tic disorder. J Formos Med Assoc. 2009;108:788-93 pubmed publisher
    ..Dopamine-blocking neuroleptics are regarded as the most effective drugs for the treatment of TS. Sulpiride is a selective dopamine D2 antagonist...
  14. Carretti N, Florio P, Reis F, Comai S, Bertazzo A, Petraglia F. Reduction of serum serotonin precursors after veralipride treatment for postmenopausal hot flushes. Climacteric. 2010;13:141-6 pubmed publisher
    ..To further elucidate this relationship, in the present study we evaluated whether administration of veralipride for relief of hot flushes is able to affect serum levels of the serotonin precursor tryptophan in postmenopausal women...
  15. Rasheed N, Ahmad A, Singh N, Singh P, Mishra V, Banu N, et al. Differential response of A 68930 and sulpiride in stress-induced gastric ulcers in rats. Eur J Pharmacol. 2010;643:121-8 pubmed publisher
    ..receptor agonist (A 68930) and antagonist (SCH 23390), and D(2) receptor agonist (quinpirole) and antagonist (sulpiride) were used to evaluate their effects on acute stress (single immobilization for 150 min) and chronic ..
  16. Walash M, Sharaf el Din M, El Enany N, Eid M, Shalan S. First derivative synchronous fluorescence spectroscopy for the simultaneous determination of sulpiride and mebeverine hydrochloride in their combined tablets and application to real human plasma. J Fluoresc. 2010;20:1275-85 pubmed publisher
    ..derivative synchronous fluorometric method has been developed for the simultaneous analysis of binary mixture of sulpiride (SUL) and mebeverine hydrochloride (MEB)...
  17. Tremolizzo L, Rodriguez Menendez V, DiFrancesco J, Sala G, Galbussera A, Appollonio I, et al. Huntington's disease and HDACi: would sulpiride and valproate be of therapeutic value?. Med Hypotheses. 2007;69:964-5 pubmed
  18. Lopez Gonzalez M, Santiago A, Esteban Ortega F. Sulpiride and melatonin decrease tinnitus perception modulating the auditolimbic dopaminergic pathway. J Otolaryngol. 2007;36:213-9 pubmed
    b>Sulpiride and melatonin decrease dopamine activity. Sulpiride, a D2 antagonist of dopamine receptors, and melatonin, a pineal substance with antidopaminergic action, are administered to tinnitus patients to decrease tinnitus perception.
  19. Abdelal A, El Enany N, Belal F. Simultaneous determination of sulpiride and its alkaline degradation product by second derivative synchronous fluorescence spectroscopy. Talanta. 2009;80:880-8 pubmed publisher
    ..derivative synchronous fluorometric methods were developed for the validated and simultaneous determination of sulpiride (SLP) and its alkaline degradation product (DSLP)...
  20. Raja M, Azzoni A. Tardive dyskinesia after long-term veralipride treatment. J Neuropsychiatry Clin Neurosci. 2005;17:252-3 pubmed
  21. Sechter D, Peuskens J, Fleurot O, Rein W, Lecrubier Y. Amisulpride vs. risperidone in chronic schizophrenia: results of a 6-month double-blind study. Neuropsychopharmacology. 2002;27:1071-81 pubmed
    ..Both treatments were well tolerated and had a similar low incidence of extrapyramidal symptoms; however, amisulpride was associated with less weight gain and endocrine/sexual symptoms. ..
  22. Leucht S, Wagenpfeil S, Hamann J, Kissling W. Amisulpride is an "atypical" antipsychotic associated with low weight gain. Psychopharmacology (Berl). 2004;173:112-5 pubmed
    ..80 kg, 95% CI (0.47-1.16) with n=874. The mean weight gain at study endpoints in 1-year studies was 1.4 kg, 95% CI (0.85-1.90), n=548. Amisulpride is an atypical antipsychotic associated with low weight gain. ..
  23. Ichikawa J, Ishii H, Bonaccorso S, Fowler W, O Laughlin I, Meltzer H. 5-HT(2A) and D(2) receptor blockade increases cortical DA release via 5-HT(1A) receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release. J Neurochem. 2001;76:1521-31 pubmed
    ..M100907 (0.1 mg/kg), a 5-HT(2A) antagonist, significantly increased the ability of both S:(-)-sulpiride (10 mg/kg), a D(2) antagonist devoid of 5-HT(1A) affinity, and R:(+)-8-OH-DPAT (0...
  24. Mortimer A, Martin S, Loo H, Peuskens J. A double-blind, randomized comparative trial of amisulpride versus olanzapine for 6 months in the treatment of schizophrenia. Int Clin Psychopharmacol. 2004;19:63-9 pubmed
    ..1% and 3.9 kg) than in the amisulpride group (20.6% and 1.6 kg). The efficacy of amisulpride is not inferior to that of olanzapine in the treatment of acute schizophrenia. The side-effect profile of the two drugs differed. ..
  25. Gschwend M, Arnold P, Ring J, Martin W. Selective and sensitive determination of amisulpride in human plasma by liquid chromatography-tandem mass spectrometry with positive electrospray ionisation and multiple reaction monitoring. J Chromatogr B Analyt Technol Biomed Life Sci. 2006;831:132-9 pubmed
    ..The chemically related drug sulpiride was used as internal standard (ISTD) and a primary calibration function was established in the concentration ..
  26. Peuskens J, Moller H, Puech A. Amisulpride improves depressive symptoms in acute exacerbations of schizophrenia: comparison with haloperidol and risperidone. Eur Neuropsychopharmacol. 2002;12:305-10 pubmed
    ..001). This significant advantage in favour of amisulpride is seen from the 2nd week of treatment. ..
  27. Morgante G, Farina M, Cianci A, La Marca A, Petraglia F, De Leo V. Veralipride administered in combination with raloxifene decreases hot flushes and improves bone density in early postmenopausal women. Gynecol Endocrinol. 2004;18:194-8 pubmed
    ..These protocols could represent a new way to administer raloxifene in early postmenopausal women at high osteoporosis risk with HRT contraindication. ..
  28. Wagner M, Quednow B, Westheide J, Schlaepfer T, Maier W, Kuhn K. Cognitive improvement in schizophrenic patients does not require a serotonergic mechanism: randomized controlled trial of olanzapine vs amisulpride. Neuropsychopharmacology. 2005;30:381-90 pubmed
    ..Importantly, amisulpride was not inferior to olanzapine for any cognitive domain. Combined 5-HT(2A)/D2 receptor blockade is probably not necessary for cognitive improvement by SGAs. ..
  29. Taylor D, McAskill R. Atypical antipsychotics and weight gain--a systematic review. Acta Psychiatr Scand. 2000;101:416-32 pubmed
    ..Ziprasidone appears not to be associated with weight gain. In the absence of more compelling data, these rankings must be considered approximate and preliminary. Longer, more robust trials are needed. ..
  30. Watanabe K, Sawano T, Endo T, Sakata M, Sato J. Studies on intestinal absorption of sulpiride (2): transepithelial transport of sulpiride across the human intestinal cell line Caco-2. Biol Pharm Bull. 2002;25:1345-50 pubmed
    To determine the transport mechanism of sulpiride in an in vitro model of the human intestine, we investigated the transepithelial transport of this agent in Caco-2 cells...
  31. Basta Kaim A, Budziszewska B, Jaworska Feil L, Leskiewicz M, Tetich M, Kubera M, et al. Opposite effects of clozapine and sulpiride on the lipopolysaccharide-induced inhibition of the GR-mediated gene transcription in fibroblast cells. Pol J Pharmacol. 2003;55:1153-8 pubmed
    ..but also to modulate the immunological system, the aim of the present study was to compare the effect of sulpiride and clozapine on GR function under basal culture conditions and during activation by lipopolysaccharide (LPS)...
  32. Liu J, Cao W, Qiu H, Sun X, Yang X, Wang E. Determination of sulpiride by capillary electrophoresis with end-column electrogenerated chemiluminescence detection. Clin Chem. 2002;48:1049-58 pubmed
    ..Ru(bpy)3(2+) ECL (CE-ECL) detection that can be applied to amine-containing clinical species was developed, and the performance of CE-ECL as a quantitative method for determination of sulpiride in human plasma or urine was evaluated.
  33. David V, Durkin T, Cazala P. Differential effects of the dopamine D2/D3 receptor antagonist sulpiride on self-administration of morphine into the ventral tegmental area or the nucleus accumbens. Psychopharmacology (Berl). 2002;160:307-17 pubmed
    ..The involvement of dopamine neurotransmission in opiate reward remains controversial...
  34. Fotaki N, Symillides M, Reppas C. Canine versus in vitro data for predicting input profiles of L-sulpiride after oral administration. Eur J Pharm Sci. 2005;26:324-33 pubmed
    ..was to assess the relative usefulness of canine versus in vitro data sets in the prediction of absorption of L-sulpiride (a low permeability compound) from an immediate and an extended release formulation...
  35. Kaneno S, Fukamauchi F, Komatsu H, Koyama K, Ikawa K. Reversal effect of sulpiride on rotational behaviour of rats with unilateral frontal cortex ablation: an alternative explanation for the pharmacological mechanism of its antidepressant effect. Behav Pharmacol. 2001;12:69-73 pubmed
    The antidepressant effect of sulpiride has been generally explained as the result of its preferential blocking effect on self-inhibitory presynaptic dopamine autoreceptors at low doses. Low dose haloperidol has the same blocking effect...
  36. Farghaly O. Adsorptive stripping voltammetric determination of the antidepressant drug sulpiride. J Pharm Biomed Anal. 2000;23:783-91 pubmed
    The electrochemical behaviour of the antidepressant drug sulpiride (SP) at a hanging mercury drop electrode (HMDE) is investigated. Linear sweep cathodic stripping voltammetry (LSCSV) was used to determine sulpiride in the presence of 0...
  37. Anderson S, Schmidt H, Pierce R. Administration of the D2 dopamine receptor antagonist sulpiride into the shell, but not the core, of the nucleus accumbens attenuates cocaine priming-induced reinstatement of drug seeking. Neuropsychopharmacology. 2006;31:1452-61 pubmed
    ..A range of doses of antagonists selective for D2- (sulpiride, 0.2 or 2.0 microg), D3- (U99194A, 3.9 or 7.8 microg), or D4- (L-750,667, 5...
  38. Masmoudi K, Gras Champel V, Lemaire Hurtel A, Masson H, Munier A, Geslin J, et al. [Extrapyramidal adverse effects of veralipride (Agreal), a drug used to treat hot flushes: a propos of 17 cases]. Rev Med Interne. 2005;26:453-7 pubmed
    ..Extrapyramidal disorders associated with veralipride therapy are rarely reported and often due to a drug misuse...
  39. Baptista T, de Baptista E, Lalonde J, Plamondon J, Kin N, Beaulieu S, et al. Comparative effects of the antipsychotics sulpiride and risperidone in female rats on energy balance, body composition, fat morphology and macronutrient selection. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28:1305-11 pubmed
    Previous studies showed that the antipsychotic drugs (APDs) sulpiride (SUL) and risperidone (RIS) induced body weight gain (BWG), hyperphagia, and increased serum levels of leptin, prolactin and corticosterone in female rats...
  40. Teive H, Sa D. Worsening of Parkinsonism after the use of veralipride for treatment of menopause: case report. Arq Neuropsiquiatr. 2001;59:123-4 pubmed
    ..We emphasize the anti-dopaminergic effect of veralipride...
  41. Markianos M, Hatzimanolis J, Lykouras L. Neuroendocrine responsivities of the pituitary dopamine system in male schizophrenic patients during treatment with clozapine, olanzapine, risperidone, sulpiride, or haloperidol. Eur Arch Psychiatry Clin Neurosci. 2001;251:141-6 pubmed
    ..m. administered haloperidol, since the expected elevations depend mainly on the free remaining D2 receptors in the tuberoinfundibular tract...
  42. Diaz Cabiale Z, Fuxe K, Narvaez J, Finetti S, Antonelli T, Tanganelli S, et al. Neurotensin-induced modulation of dopamine D2 receptors and their function in rat striatum: counteraction by a NTR1-like receptor antagonist. Neuroreport. 2002;13:763-6 pubmed
    ..These data indicate that there exists in the striatum at the prejunctional level an intramembrane antagonistic NT receptor/DA D2 receptor-receptor interaction where NTR1 like receptor activation reduces the DA D2 autoreceptor function...
  43. Baptista T, Lacruz A, Paez X, Hernandez L, Beaulieu S. The antipsychotic drug sulpiride does not affect bodyweight in male rats. Is insulin resistance involved?. Eur J Pharmacol. 2002;447:91-8 pubmed
    ..To explore the mechanisms involved in this sex-dependent effect, we administered the dopamine antagonist sulpiride (20 mg/kg i.p.) or vehicle (0...
  44. Vaiva G, Thomas P, Llorca P, Dupont S, Cottencin O, Devos P, et al. SPECT imaging, clinical features, and cognition before and after low doses of amisulpride in schizophrenic patients with the deficit syndrome. Psychiatry Res. 2002;115:37-48 pubmed
    ..The psychometric and cerebral perfusion changes were no different in the two groups...
  45. Baptista T, Araujo de Baptista E, Ying Kin N, Beaulieu S, Walker D, Joober R, et al. Comparative effects of the antipsychotics sulpiride or risperidone in rats. I: bodyweight, food intake, body composition, hormones and glucose tolerance. Brain Res. 2002;957:144-51 pubmed
    ..The currently available animal model of AP-induced bodyweight gain (BWG) in rats is based on administration of sulpiride (SUL). However, this model has important limitations...
  46. Baluom M, Friedman M, Rubinstein A. Improved intestinal absorption of sulpiride in rats with synchronized oral delivery systems. J Control Release. 2001;70:139-47 pubmed
    The goals of this study were to examine whether formulations, capable of releasing sulpiride (SP) in synchrony with the p-Glycoprotein (P-gp) inhibitors, verapamil (Ver) or quinidine (Qn) can increase SP relative bioavailability and to ..
  47. Cassel J, Lazaris A, Birthelmer A, Jackisch R. Spatial reference- (not working- or procedural-) memory performance of aged rats in the water maze predicts the magnitude of sulpiride-induced facilitation of acetylcholine release by striatal slices. Neurobiol Aging. 2007;28:1270-85 pubmed
    ..in the presence of oxotremorine, physostigmine, atropine+physostigmine, quinpirole, nomifensine or sulpiride. Aged rats exhibited reduced accumulation of [(3)H]choline (-30%) and weaker transmitter release...
  48. Srebrnik A, Shachar E, Brenner S. Suspected induction of a pyoderma gangrenosum-like eruption due to sulpiride treatment. Cutis. 2001;67:253-6 pubmed
    A case of a pyoderma gangrenosum (PG)-like eruption due to the antipsychotic drug sulpiride, a form of risperidone, is described...
  49. Lecrubier Y, Azorin M, Bottai T, Dalery J, Garreau G, Lemperiere T, et al. Consensus on the Practical Use of Amisulpride, an Atypical Antipsychotic, in the Treatment of Schizophrenia. Neuropsychobiology. 2001;44:41-6 pubmed
    ..The French experience emphasizes the central role of amisulpride as a first-line treatment of schizophrenia...
  50. Leucht S, Pitschel Walz G, Engel R, Kissling W. Amisulpride, an unusual "atypical" antipsychotic: a meta-analysis of randomized controlled trials. Am J Psychiatry. 2002;159:180-90 pubmed
    ..The purpose of this article was to compare the atypical profile of amisulpride with that of the 5-HT(2)/D(2) antagonists...
  51. Muller M, Wetzel H, Benkert O. Differential effects of high-dose amisulpride versus flupentixol on latent dimensions of depressive and negative symptomatology in acute schizophrenia: an evaluation using confirmatory factor analysis. Int Clin Psychopharmacol. 2002;17:249-61 pubmed
    ..CFA-based analyses appear to be suitable for psychotropic drug evaluation when more refined and data-related information on drug efficacy profiles are required...
  52. Abbate F, Coetzee A, Casini A, Ciattini S, Scozzafava A, Supuran C. Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride. Bioorg Med Chem Lett. 2004;14:337-41 pubmed
    The X-ray crystal structure for the adduct of human carbonic anhydrase (hCA) II with sulpiride, a sulfonamide derivative clinically used as antipsychotic drug, has been resolved at a resolution of 1.6 A...
  53. Mehta M, Manes F, Magnolfi G, Sahakian B, Robbins T. Impaired set-shifting and dissociable effects on tests of spatial working memory following the dopamine D2 receptor antagonist sulpiride in human volunteers. Psychopharmacology (Berl). 2004;176:331-42 pubmed
    ..These include working memory and set-shifting deficits. Theories of DA function have predicted that distraction or impaired switching may be important determinants of such deficits...
  54. Schlosser R, Grunder G, Anghelescu I, Hillert A, Ewald Gründer S, Hiemke C, et al. Long-term effects of the substituted benzamide derivative amisulpride on baseline and stimulated prolactin levels. Neuropsychobiology. 2002;46:33-40 pubmed
    ..However, the findings indicate also that treatment with amisulpride at clinically effective doses can be achieved at significantly lower prolactin levels during the long-term maintenance phase than during the prior acute phase...
  55. Passetti F, Levita L, Robbins T. Sulpiride alleviates the attentional impairments of rats with medial prefrontal cortex lesions. Behav Brain Res. 2003;138:59-69 pubmed
    ..of rats with mPFC lesions were alleviated by systemic administration of the dopamine D2 receptor antagonist sulpiride. In contrast, rats with PRL-IL damage were not affected and control rats were impaired by sulpiride...
  56. Engleman E, McBride W, Li T, Lumeng L, Murphy J. Ethanol drinking experience attenuates (-)sulpiride-induced increases in extracellular dopamine levels in the nucleus accumbens of alcohol-preferring (P) rats. Alcohol Clin Exp Res. 2003;27:424-31 pubmed
    ..This study examines the effects of local application of the DA D(2) receptor antagonist (-)sulpiride (SUL) on ethanol drinking of alcohol-preferring (P) rats, and extracellular DA levels in the nucleus accumbens (..
  57. Hwang T, Lee S, Sun H, Lin H, Tsai S, Lee Y, et al. Amisulpride versus risperidone in the treatment of schizophrenic patients: a double-blind pilot study in Taiwan. J Formos Med Assoc. 2003;102:30-6 pubmed
    ..There have been no controlled studies comparing amisulpride to risperidone in Asian patients. The purpose of this study was to compare the efficacy and safety of amisulpride with that of risperidone in Taiwanese schizophrenic patients...
  58. Honey G, Suckling J, Zelaya F, Long C, Routledge C, Jackson S, et al. Dopaminergic drug effects on physiological connectivity in a human cortico-striato-thalamic system. Brain. 2003;126:1767-81 pubmed
    ..of physiological connectivity between CST regions following treatment with drugs which served both to decrease (sulpiride) and increase (methylphenidate) dopaminergic transmission, as well as non-dopaminergic treatments (diazepam and ..
  59. Mortimer A. How do we choose between atypical antipsychotics? The advantages of amisulpride. Int J Neuropsychopharmacol. 2004;7 Suppl 1:S21-5 pubmed
    ..In two clinical trials, the AMIRIS and SOLIANOL studies, amisulpride demonstrated clear advantages over some other atypical antipsychotics with respect to negative symptoms, depressive symptoms and weight gain...
  60. Schmitz Y, Lee C, Schmauss C, Gonon F, Sulzer D. Amphetamine distorts stimulation-dependent dopamine overflow: effects on D2 autoreceptors, transporters, and synaptic vesicle stores. J Neurosci. 2001;21:5916-24 pubmed
    ..We used the D2 receptor antagonist sulpiride and mice lacking the D2 receptor to address this issue...
  61. O Tuathaigh C, Moran P. The effect of sulpiride on amphetamine-induced disruption of overshadowing in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28:1249-53 pubmed
    ..In the present study, we examined the ability of the selective DA D2 receptor antagonist sulpiride to reverse amphetamine-induced disruption of overshadowing, in the conditioned emotional response (CER) ..
  62. Mehta M, Hinton E, Montgomery A, Bantick R, Grasby P. Sulpiride and mnemonic function: effects of a dopamine D2 receptor antagonist on working memory, emotional memory and long-term memory in healthy volunteers. J Psychopharmacol. 2005;19:29-38 pubmed
    ..We have therefore tested the effects of the dopamine D2 receptor antagonist sulpiride (400 mg) on WM and learning tasks, including those using auditory, spatial or non-spatial stimuli...
  63. Zayed S. Simultaneous determination of mebeverine hydrochloride and sulpiride using the first derivatives of ratio spectra and chemometric methods. Anal Sci. 2005;21:985-9 pubmed
    Two methods are described for the simultaneous determination of mebeverine hydrochloride (MB) and sulpiride (SU) in their combinations...