indoramin

Summary

Summary: An alpha-1 adrenergic antagonist that is commonly used as an antihypertensive agent.

Top Publications

  1. Bache R, Homans D, Schwartz J, Dai X. Differences in the effects of alpha-1 adrenergic blockade with prazosin and indoramin on coronary blood flow during exercise. J Pharmacol Exp Ther. 1988;245:232-7 pubmed
    This study compared the effects of two selective alpha-1 adrenergic blockers, prazosin and indoramin, on the response of coronary blood flow and myocardial oxygen consumption during treadmill exercise in chronically instrumented dogs...
  2. Pierce D. A review of the clinical pharmacokinetics and metabolism of the alpha 1-adrenoceptor antagonist indoramin. Xenobiotica. 1990;20:1357-67 pubmed
    1. The alpha 1-adrenoceptor antagonist indoramin is rapidly and extensively absorbed after oral administration, but with only low to moderate bioavailability (8-24% median) from the tablet (Baratol)...
  3. Villa A, Hong H, Lee H, Chataigner D, Garnier R. [Not Available]. Therapie. 2012;67:523-7 pubmed publisher
    Authors report a retrospective study of all cases of indoramin-only poisoning notified to the Paris poison Centre from 1986 to 2010. Fifty five cases of indoramin self-poisoning were included: 40 adults and 15 children...
  4. Lloyd S, McMahon A, Muller W, Buckley J, Deane R, Kirk D, et al. Is indoramin an effective alternative to prostatectomy?. Br J Urol. 1992;70:408-11 pubmed
    ..awaiting prostatectomy were assessed (by symptom scores and peak urinary flow rates) prior to treatment, on indoramin 20 mg bd, and 2 months following prostatectomy...
  5. Ishizuka O, Mattiasson A, Steers W, Andersson K. Effects of spinal alpha 1-adrenoceptor antagonism on bladder activity induced by apomorphine in conscious rats with and without bladder outlet obstruction. Neurourol Urodyn. 1997;16:191-200 pubmed
    ..micrograms/kg, induced bladder activity that was abolished or attenuated by the alpha 1-adrenoceptor antagonists indoramin and doxazosin given intrathecally or intra-arterially...
  6. Pertwee R, Hedley D, McQueen A, Gentleman S. The hypothermic response of mice to delta-9-tetrahydrocannabinol is enhanced by chlorpromazine, thioxanthenes, alpha-adrenoceptor antagonists and pentolinium but not by SCH 23390 or sulpiride. Neuropharmacology. 1988;27:149-55 pubmed
    ..c.), piflutixol (23.4 micrograms/kg s.c.), pentolinium (5 mg/kg s.c.), prazosin (0.1875 mg/kg s.c.) and indoramin (6 mg/kg s.c.) but not by SCH 23390 (6 mg/kg s.c.) or sulpiride (40 mg/kg s.c.)...
  7. Pitt J, Craggs M, Henry M, Boulos P. Alpha-1 adrenoceptor blockade: potential new treatment for anal fissures. Dis Colon Rectum. 2000;43:800-3 pubmed
    ..The objective of this study was to determine the effect of alpha-1 adrenoceptor blockade on anal sphincter pressure in patients with and without chronic anal fissures...
  8. Henry P. [Migraine: a disease, not a symptom]. Rev Prat. 2002;52:5-7 pubmed
  9. James M, Jones J. Anti-arrhythmic properties of the alpha-adrenoceptor blocking drug indoramin. Br J Clin Pharmacol. 1991;32:375-8 pubmed
    1. The anti-arrhythmic properties of the alpha-adrenoceptor blocking drug indoramin were compared with the effect of disopyramide and placebo in a randomised, single-blind, cross-over study...

More Information

Publications46

  1. Raftery E, Gould B. The effect of placebo on indirect and direct blood pressure measurements. J Hypertens Suppl. 1990;8:S93-100 pubmed
    ..Therefore, clinical trials of antihypertensive drugs using the intra-arterial method do not need a placebo control, whereas a placebo control is essential in all trials using the indirect technique for measuring blood pressure...
  2. Sengupta S, Cooney R, Baj M, Ni Muircheartaigh R, O Donnell L. Prokinetic effect of indoramin, an alpha-adrenergic antagonist, on human gall-bladder. Aliment Pharmacol Ther. 2002;16:1801-3 pubmed
    ..The effects of alpha- and beta-adrenergic agents on gall-bladder motility remain undefined...
  3. Garner J, McFall M, Edwards D. The medical and surgical management of chronic anal fissure. J R Army Med Corps. 2002;148:230-5 pubmed
    ..These new treatments are examined in the context of traditional surgical management of the disease and a future treatment algorithm suggested...
  4. Iacovou J, Dunn M. Indoramin--an effective new drug in the management of bladder outflow obstruction. Br J Urol. 1987;60:526-8 pubmed
    There is a need for symptomatic relief in some patients with bladder outflow obstruction. The alpha blocker indoramin was tested in a prospective, double-blind, placebo-controlled trial. Thirty men were given indoramin or placebo...
  5. Deering A, Riddell J, Harron D, Shanks R. Effect of acute and chronic indoramin administration on baroreflex function and tremor in humans. J Cardiovasc Pharmacol. 1988;11:284-90 pubmed
    ..of reflex tachycardia in response to the hypotensive effect of the selective alpha 1-adrenoceptor antagonist indoramin, including, in animals, membrane-stabilising activity, prolongation of repolarisation time, and reduction in ..
  6. Watson A, Currie I, Jarvis G. A prospective placebo controlled double blind randomised study to investigate the use of indoramin to prevent post-operative voiding disorders after surgical treatment for genuine stress incontinence. Br J Obstet Gynaecol. 1999;106:270-2 pubmed
    A prospective placebo controlled double blind randomised study was undertaken to investigate the use of indoramin an alpha blocker to prevent post-operative voiding disorders after surgical treatment for genuine stress incontinence...
  7. Sengupta S, Modak P, McCauley N, O Donnell L. Prokinetic effect of alpha-adrenergic antagonist, and beta-adrenergic antagonist on gall-bladder motility in humans with gall-stone disease. Eur J Gastroenterol Hepatol. 2007;19:581-3 pubmed
    ..Alpha adrenergic antagonists have been found in previous studies to have a prokinetic effect on gall-bladder motility in normal human patients. Their effects have not, however, been fully elucidated in patients with gall-stone disease...
  8. O Riordan J, Doherty C, Javed M, Brophy D, Hutchinson M, Quinlan D. Do alpha-blockers have a role in lower urinary tract dysfunction in multiple sclerosis?. J Urol. 1995;153:1114-6 pubmed
    ..test the hypothesis that blockade of these receptors using the selective alpha 1-adrenergic receptor antagonist indoramin would improve bladder emptying in patients with multiple sclerosis...
  9. Pupo A, Cavenaghi D, Campos M, Lucena Morais P, Jurkiewicz N, Jurkiewicz A. Effects of indoramin in rat vas deferens and aorta: concomitant alpha1-adrenoceptor and neuronal uptake blockade. Br J Pharmacol. 1999;127:1832-6 pubmed
    1. The actions of the alpha1-adrenoceptor antagonist indoramin have been examined against the contractions induced by noradrenaline in the rat vas deferens and aorta taking into account a putative neuronal uptake blocking activity of ..
  10. Kirsten R, Nelson K, Kirsten D, Heintz B. Clinical pharmacokinetics of vasodilators. Part II. Clin Pharmacokinet. 1998;35:9-36 pubmed
    ..The use of overly aggressive antihypertensive therapy during pregnancy should be avoided so that adequate uteroplacental blood flow is maintained. Methyldopa is the only drug accepted for use during the first trimester of pregnancy...
  11. Villa A, Tran Hong H, Lee H, Chataigner D, Garnier R. Acute indoramin poisoning: a review of 55 cases reported to the Paris Poison Centre from 1986 t o 2010. Therapie. 2012;67:523-7 pubmed publisher
    Authors report a retrospective study of all cases of indoramin-only poisoning notified to the Paris poison Centre from 1986 to 2010. Fifty five cases of indoramin self-poisoning were included: 40 adults and 15 children...
  12. Ishizuka O, Pandita R, Mattiasson A, Steers W, Andersson K. Stimulation of bladder activity by volume, L-dopa and capsaicin in normal conscious rats--effects of spinal alpha 1-adrenoceptor blockade. Naunyn Schmiedebergs Arch Pharmacol. 1997;355:787-93 pubmed
    ..t.) or intra-arterial (i.a.) administration of the alpha 1-adrenoceptor antagonist, indoramin. Indoramin is selective for the alpha 1A-adrenoceptor subtype, whereas most clinically used alpha 1-adrenoceptor ..
  13. Pierce D, Abrams S, Franklin R. Pharmacokinetics and systemic availability of the antihypertensive agent indoramin and its metabolite 6-hydroxyindoramin in healthy subjects. Eur J Clin Pharmacol. 1987;32:619-23 pubmed
    We have studied the pharmacokinetics and absolute systemic availability of indoramin (50 mg) given orally in solution or as a tablet with reference to intravenously administered drug (0.15 mg/kg) in 9 healthy volunteers...
  14. Niveditha Y, Bishop N, Boyle R, Stoker J, Mary D. Changes in myocardial ischaemia during isosorbide dinitrate or indoramin therapy in patients with stable angina using relations between the ST segment and heart rate. Int J Cardiol. 1988;19:341-54 pubmed
    The effect of isosorbide dinitrate or indoramin on myocardial ischaemia was examined in patients with stable angina pectoris...
  15. Chow W, Hahn D, Sandhu D, Slaney P, Henshaw R, Das G, et al. Multicentre controlled trial of indoramin in the symptomatic relief of benign prostatic hypertrophy. Br J Urol. 1990;65:36-8 pubmed
    ..benign prostatic hypertrophy were entered into a double-blind, parallel group, multicentre study of 2 doses of indoramin versus placebo. There were 18 withdrawals or exclusions, leaving 121 patients for analysis...
  16. Good A, Unverferth D, Leier C. Hemodynamic responses to different levels of alpha-adrenergic interruption in congestive heart failure. Cardiovasc Drugs Ther. 1988;1:529-34 pubmed
    The effects of prazosin, clonidine, and indoramin on central and regional hemodynamic parameters and left ventricular performance were analyzed in a congestive heart failure population to compare the pharmacodynamic responses to ..
  17. Pierce D, Warrington S, Franklin R. Pharmacokinetics of indoramin and its 6-hydroxylated metabolite after repeated oral dosing. Biopharm Drug Dispos. 1988;9:147-57 pubmed
    The pharmacokinetics of indoramin and its active 6-hydroxylated metabolite have been studied in healthy male volunteers after repeated oral dosing with 37.5 mg twice daily for 2 weeks...
  18. Stott M, Abrams P. Indoramin in the treatment of prostatic bladder outflow obstruction. Br J Urol. 1991;67:499-501 pubmed
    A series of 40 patients took part in a double-blind, placebo-controlled trial of indoramin in prostatic bladder outflow obstruction. Patients were assessed clinically and urodynamically before and after 4 weeks' treatment...
  19. Schabort I, Odendaal H, Pierce D. The pharmacokinetics of oral indoramin during pregnancy. Br J Clin Pharmacol. 1990;29:397-401 pubmed
    1. The pharmacokinetics of indoramin (Baratol; Wyeth) and its active metabolite 6-hydroxyindoramin administered to 13 women as a single 37.5 mg dose of indoramin were compared under pregnant and post-partum conditions. 2...
  20. Berkenboom G, Unger P. Alpha-adrenergic coronary constriction in effort angina. Basic Res Cardiol. 1990;85 Suppl 1:359-69 pubmed
    ..After recovery, either phentolamine (for the first nine patients) or indoramin (for the following nine patients) was directly injected into the most diseased vessel at identical doses (2 mg ..
  21. Grossman P, Stemmler G, Meinhardt E. Paced respiratory sinus arrhythmia as an index of cardiac parasympathetic tone during varying behavioral tasks. Psychophysiology. 1990;27:404-16 pubmed
    ..Furthermore, our findings suggest that cardiac vagal tone is responsive to varying behavioral demands and may interact in different ways with beta-adrenergic mechanisms...
  22. Bennett J, Weich D, Schoeman H. Double-blind study comparing indoramin and propranolol in the treatment of black patients with hypertension. S Afr Med J. 1988;74:619-21 pubmed
    ..randomised study of 50 black hypertensive patients was designed to compare the efficacy and safety of indoramin (Baratol; Wyeth/Ayerst) and propranolol in patients who did not respond to diuretic therapy alone...
  23. GagaƂo I, Szreder Z. The effect of doxazosin, urapidil and indoramin pretreatment on fever produced by E. coli lipopolysaccharide in rabbits. Gen Pharmacol. 1991;22:923-7 pubmed
    1. Thermal responses to i.v. administration of doxazosin (0.75 or 1.50 mg/kg), urapidil (5.0 or 10.0 mg/kg), or indoramin (0.75 or 1...
  24. Medhi B, Rao R, Prakash A, Prakash O, Kaman L, Pandhi P. Recent advances in the pharmacotherapy of chronic anal fissure: an update. Asian J Surg. 2008;31:154-63 pubmed publisher
    ..2% GTN ointment but was associated with fewer side effects. Other drugs that have been tried are lidocaine, the alpha-adrenergic antagonist indoramin, and the potassium channel opener minoxidil.
  25. Muller C, Worthington M, Thandroyen F. Antiarrhythmic and metabolic effects of indoramin during acute regional ischemia and reperfusion in isolated rat heart. J Cardiovasc Pharmacol. 1990;15:408-13 pubmed
    ..The potential antiarrhythmic properties of indoramin, an alpha 1-antagonist, were assessed in the isolated perfused rat heart during regional ischemia and during ..
  26. Acheson A, Scholefield J. Pharmacological advancements in the treatment of chronic anal fissure. Expert Opin Pharmacother. 2005;6:2475-81 pubmed
    ..This review looks at those pharmacological agents used commonly in the treatment of chronic anal fissures and explores alternative therapies that may be of benefit in the future...
  27. Gupta P. Current treatment options for fissure-in-ano. J Med Liban. 2004;52:33-8 pubmed
    ..While acute fissures could be managed with medical therapy alone, chronic fissures do need some form of manipulation to relieve internal sphincter spasm...
  28. Anthony J, Rees A, Davey D. Indoramin in the treatment of pregnancy hypertension. A placebo-controlled trial comparing the efficacy of indoramin with alpha-methyldopa. S Afr Med J. 1990;78:458-61 pubmed
    A placebo-controlled trial was used to assess the antihypertensive efficacy of indoramin in the management of pregnancy hypertension. Sixty patients were recruited into the study and only 17 attained satisfactory blood pressure control...
  29. Taddei S, Salvetti A, Pedrinelli R. Further evidence for the existence of alpha 2-mediated adrenergic vasoconstriction in human vessels. Eur J Clin Pharmacol. 1988;34:407-10 pubmed
    ..vasculature, the effect of selective alpha 1- and alpha 2-agonists (methoxamine and B-HT 933) and antagonists (indoramin and Yohimbine) was studied in fourteen patients with mild, uncomplicated, essential hypertension...
  30. Warren J, Dollery C. The usefulness of alpha-adrenoceptor blockade in the treatment of hypertension. J Hypertens Suppl. 1988;6:S43-9 pubmed
    ..Although many new drugs are being developed, little information is available yet on the long-term outcome of therapy with this class of drugs for patients with hypertension...
  31. Pierce D, Smith S, Franklin R. The pharmacokinetics of indoramin and 6-hydroxyindoramin in poor and extensive hydroxylators of debrisoquine. Eur J Clin Pharmacol. 1987;33:59-65 pubmed
    ..metabolisers (PM) and seven extensive metabolisers (EM), of debrisoquine, all healthy volunteers, received 50 mg indoramin orally following an overnight fast...
  32. Pierce D, Abrams S, Franklin R. Intra- and inter-subject variation in the pharmacokinetics of indoramin and its 6-hydroxylated metabolite. Eur J Clin Pharmacol. 1988;35:195-8 pubmed
    Intra- and inter-subject variation in the kinetics of indoramin and its active metabolite 6-hydroxyindoramin have been studied in 5 young, healthy, male volunteers administered a single oral dose of the drug on 5 separate occasions...
  33. Clifford G, Farmer R. Medical therapy for benign prostatic hyperplasia: a review of the literature. Eur Urol. 2000;38:2-19 pubmed
    ..trials investigating the six alpha-adrenergic receptor antagonists (alpha-blockers), prazosin, alfuzosin, indoramin, terazosin, doxazosin, and tamsulosin, that benefit patients by relaxing prostatic smooth muscle, and the anti-..
  34. Hussain M, Marshall I. Alpha(1)-adrenoceptor subtypes mediating contractions of the rat mesenteric artery. Eur J Pharmacol. 2000;395:69-76 pubmed
    ..The results with both agonists and antagonists are consistent with contractions of the rat mesenteric artery being mediated via the alpha(1D)- and possibly alpha(1B)-adrenoceptor...
  35. Abrams S, Pierce D, Johnston A, Hedges A, Franklin R, Turner P. Pharmacokinetic interaction between indoramin and ethanol. Hum Toxicol. 1989;8:237-41 pubmed
    1. The effect of ethanol consumption (0.5 g/kg) on the pharmacokinetics of the alpha adrenoceptor antagonist indoramin, administered orally (50 mg) or intravenously (0.175 mg/kg) has been investigated in young volunteers...
  36. Hussain M, Marshall I. Characterization of alpha1-adrenoceptor subtypes mediating contractions to phenylephrine in rat thoracic aorta, mesenteric artery and pulmonary artery. Br J Pharmacol. 1997;122:849-58 pubmed
    ..9), WB4101 (pA2 9.6), 5-methylurapidil (pA2 8.1), benoxathian (pA2 9.2) and indoramin (pA2 7.4)...
  37. Nasher A, Qirbi A, Ghafoor M, Catterall A, Thompson A, Ramsay J, et al. Khat chewing and bladder neck dysfunction. A randomized controlled trial of alpha 1-adrenergic blockade. Br J Urol. 1995;75:597-8 pubmed
    To assess whether the effect of chewing khat leaves (Catha edulis) on the urodynamics of healthy males is altered by the selective alpha 1-adrenergic blocking agent indoramin in a prospective randomized double-blind controlled trial.