iodohippuric acid


Summary: An iodine-containing compound used in pyelography as a radiopaque medium. If labeled with radioiodine, it can be used for studies of renal function.

Top Publications

  1. Kowalczyk M. [Mean elimination time of the impulse radiotracer (131I-hippurate) as a marker of renal function]. Folia Med Cracov. 1990;31:63-9 pubmed
    ..The enlisted characteristics seem to predispose the proposed method of renal function evaluation for application in screening isotope tests. ..
  2. Pavia J, Ros D, Piera C, Pavia A, Bassa P, Giralt E, et al. Comparative study of the kinetics of the renal tracers 99Tcm-MAG3 and 131I-hippuran. Nucl Med Commun. 1991;12:529-37 pubmed
    ..982) with a ratio of 0.57 between them. The volumes of distribution in litres were 4.1 (MAG) and 7.0 (OIH). One-hour urine excretion was nearly the same for both tracers (MAG: 64%, OIH: 63% of the injected dose). ..
  3. Lear J, Feyerabend A, Gregory C. Two-compartment, two-sample technique for accurate estimation of effective renal plasma flow: theoretical development and comparison with other methods. Radiology. 1989;172:431-6 pubmed
    ..The new two-compartment, two-sample technique yielded estimates of ERPF that more closely agreed with the reference multiple-sample method than either the single-sample or slope-intercept techniques. ..
  4. Areekul S. Renal plasma flow in rhesus monkeys infected with Plasmodium knowlesi. Southeast Asian J Trop Med Public Health. 1987;18:186-92 pubmed
    ..These findings indicated that the renal plasma flow in the infected monkeys was depressed in proportion to the number of P. knowlesi parasites. The mechanism of reduced renal plasma flow was probably due to renal vasoconstriction. ..
  5. Miralbell R, Sancho G, Bieri S, Carrio I, Helg C, Brunet S, et al. Renal insufficiency in patients with hematologic malignancies undergoing total body irradiation and bone marrow transplantation: a prospective assessment. Int J Radiat Oncol Biol Phys. 2004;58:809-16 pubmed
    ..Prostaglandin E(1) use correlated with a significant reduction in ERPF at both 4 and 12-18 months. ..
  6. Lee H, Blaufox M. Technetium-99m MAG-3 clearances after captopril in experimental renovascular hypertension. J Nucl Med. 1989;30:666-71 pubmed
    ..Changes in renal function after Captopril depend on the model of renovascular hypertension and possibly the dose administered. Technetium-99m MAG-3 clearance parallels [131I]orthoiodohippurate in renovascular hypertension. ..
  7. Chen C, Huang S, Yang T, Chang M. Effective renal plasma flow response and atrial natriuretic peptide in patients with uncomplicated acute myocardial infarction. Jpn Heart J. 1993;34:1-10 pubmed
    ..2, 65.6 +/- 20.8, 57.4 +/- 19.2 pg/ml, respectively). It was concluded that, in the presence of uncomplicated acute myocardial infarction, patients may show renal vasodilatation, and that the elevation of ANP may play some role in this. ..
  8. Heckl W, Osterhage H, Frohmuller H. Are antireflux procedures indicated in patients with small pyelonephritic kidneys?. Eur Urol. 1987;13:224-8 pubmed
    ..Urinary tract infection was eliminated in 12 of the 16 cases. It can be concluded that a small pyelonephritic kidney associated with a vesicoureteral reflux should not be removed even if its isotopic clearance is less than 100 ml/min. ..
  9. Koranda P, Lüscher D, Lourens S, Rösler H. Optimal sampling times for OIH-clearance calculations using a two-compartment/two-sample method. Nuklearmedizin. 1995;34:156-60 pubmed
    ..The most reliable results with the Lear method in this patient population were obtained by taking a first sample at approximately 8 min p.i., and a second sample at 32 min p.i. or later. ..

More Information

Publications112 found, 100 shown here

  1. Ozker K, Onsel C, Kabasakal L, Sayman H, Uslu I, Bozluolçay S, et al. Technetium-99m-N,N-ethylenedicysteine--a comparative study of renal scintigraphy with technetium-99m-MAG3 and iodine-131-OIH in patients with obstructive renal disease. J Nucl Med. 1994;35:840-5 pubmed
    ..85 min, respectively. It is concluded that 99mTc-EC has excellent imaging characteristics and similar excretion properties to OIH. The advantages of 99mTc-EC over 99mTc-MAG3 are lower hepatobiliary uptake and simplicity of preparation. ..
  2. Clorius J, Hupp T, Zuna I, Schmidlin P, Denk S, van Kaick G. The exercise renogram and its interpretation. J Nucl Med. 1997;38:1146-51 pubmed
    ..Exercise renography's only indication is for recognition of pathology unique to hypertension, since other function disturbances were recognized in resting renograms. ..
  3. Lipowska M, Jarkas N, Voll R, Nye J, Klenc J, Goodman M, et al. Re(CO)3([18F]FEDA), a novel 18F PET renal tracer: Radiosynthesis and preclinical evaluation. Nucl Med Biol. 2018;58:42-50 pubmed publisher
    ..These promising in vivo results warrant subsequent evaluation in humans. ..
  4. Gale B, Zhang C, Lee H, Heller S, Blaufox M. The effect of captopril on glucoheptonate uptake in experimental renal artery stenosis. Nucl Med Commun. 1992;13:110-3 pubmed
    ..Moreover, the data support a potential value of glucoheptonate in captopril renography. ..
  5. Zuckier L, Patel Y, Fine E, Koenigsberg M. Fraley's syndrome: case report and update on current diagnostic methods. Urol Radiol. 1988;10:103-6 pubmed
    ..Ultrasound imaging, by monitoring upper-pole dilatation, may provide complementary morphologic information important for long-term follow-up. ..
  6. Bagni B, Bagni I, Orsolon P, Corazzari T. How gender and age affect iodine-131-OIH and technetium-99m-MAG3 clearance. J Nucl Med Technol. 2000;28:156-8 pubmed
  7. Casadevall G, Piera C, Setoain J, Queralt J. Age-dependent enzymuria, proteinuria and changes in renal blood flow and glomerular filtration rate in rats. Mech Ageing Dev. 1995;82:51-60 pubmed
    ..The present findings indicate that urinary markers of renal injury increase with age, whereas GFR and RBF only decrease when expressed as clearance related to body weight. ..
  8. Roca M, Puchal R, Garcia V, Iglesias F, Gomes V, Mora J, et al. [Effective renal plasma flow with I-131-hipuran: evaluation of a method with four extractions]. Rev Esp Med Nucl. 1998;17:265-71 pubmed
    ..i. was the best of them with a correlation factor with the standard equal to 0.997, an EA that ranged from -63 ml/min to 49 ml/min (mean: -4 ml/min) and a SEE of 19.5 ml/min. ..
  9. Fujioka Y, Satake S, Uehara T, Mukai T, Akizawa H, Ogawa K, et al. In vitro system to estimate renal brush border enzyme-mediated cleavage of Peptide linkages for designing radiolabeled antibody fragments of low renal radioactivity levels. Bioconjug Chem. 2005;16:1610-6 pubmed HML by the action of renal brush border enzymes, followed by urinary excretion of the resulting m-iodohippuric acid. In this study, an in vitro system using brush border membrane vesicles (BBMVs) isolated from the rat kidney ..
  10. Taylor A, Corrigan P, Eshima D, Folks R. Prospective validation of a single sample technique to determine technetium-99m-MAG3 clearance. J Nucl Med. 1992;33:1620-2 pubmed
    ..01 with an intercept of -26.6; the standard error of the estimate was 24 ml/min. In conclusion, the current regression equation provides a good estimate of 99mTc-MAG3 clearance. ..
  11. Dormehl I, Van Wyk A, Pilloy W, Maree M, Knoesen O, de Winter R, et al. Using the "integral spleen" method of radiorenogram analysis and a baboon model to compare the diagnostic usefulness of technetium-99m-diethylenetriamine pentaacetic acid to that of various technetium-99m-mercaptoacetyltriglycene formulatio. Am J Physiol Imaging. 1989;4:23-7 pubmed
    ..Inexpensive 99mTc-DTPA in conjunction with modern computer techniques will probably supply most of the answers. ..
  12. Lee V, Allard J, Foster J, Sheahan K, Franklin P. Functional oncocytoma of the kidney: evaluation by dual tracer scintigraphy. J Nucl Med. 1987;28:1911-4 pubmed
    ..We offer an explanation for such exceptional scintigraphic finding, which may potentially enable us to make a pre-operative diagnosis of renal oncocytoma in the future. ..
  13. Hutchings M, Hesse B, Grønvall J, Olsen N. Renal 131I-hippuran extraction in man: effects of dopamine. Br J Clin Pharmacol. 2002;54:675-7 pubmed
    ..002). Dopamine induced increases in renal blood flow are largely under-estimated when measurements are not corrected for incomplete extraction of 131I-hippuran. ..
  14. Anderson R, Bueschen A, Lloyd L, Dubovsky E, Burns J. Short-term and long-term changes in renal function after donor nephrectomy. J Urol. 1991;145:11-3 pubmed
    ..4 ml. per minute at 10 years. This result is similar to the decrease seen in the normal population. According to our results, renal donation by living related persons does not lead to long-term decrease in renal function. ..
  15. Kengen R, Meijer S, Van Zanten A, Beekhuis H, Kosterink J, Albertus Piers D. Iodine-131 Hippuran for the estimation of renal plasma flow: requirements for radiochemical purity. Eur J Nucl Med. 1995;22:678-81 pubmed
    ..The 131I-iodide concentration in plasma relative to the 131I-Hippuran concentration will be higher in patients with high ERPF values.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  16. O Malley J, Ziessman H, Chantarapitak N. Tc-99m MAG3 as an alternative to Tc-99m DTPA and I-131 Hippuran for renal transplant evaluation. Clin Nucl Med. 1993;18:22-9 pubmed
    ..In conclusion, Tc-99m MAG3 is superior to I-131 Hippuran for evaluation of renal transplant function. Tc-99m is the agent of choice for evaluation of renal transplant blood flow and function. ..
  17. Fine E, Li Y, Blaufox M. Parenchymal mean transit time analysis of 99mTc-DTPA captopril renography. J Nucl Med. 2000;41:1627-31 pubmed
  18. Piepenburg R, Melchior S, Steinert H, Hohenfellner R, Hahn K. [Quantitative nuclear medicine kidney diagnosis with kidney tubule traversing radioisotopes]. Urologe A. 1993;32:81-93 pubmed
    ..In addition, they allow answers to highly specific clinical and scientific questions in nephrology and urology. ..
  19. Barthez P, Chew D, DiBartola S. Simplified methods for estimation of 99mTc-pentetate and 131I-orthoiodohippurate plasma clearance in dogs and cats. J Vet Intern Med. 2001;15:200-8 pubmed
  20. De Sadeleer C. Reassessment of the reproducibility of Technetium-99m mercaptoacetyltriglycine clearance. Nucl Med Rev Cent East Eur. 2005;8:15-20 pubmed
    ..8, 47.7 and 57.7 ml/min/1.73 m2 between tests 1 and 2, tests 1 and 3, and tests 2 and 3. Whether such a large variability is acceptable in clinical practice depends solely on what the clinician is expecting. ..
  21. Trejtnar F, Laznicek M, Laznickova A. Comparison of 99mTc-mercaptoacetyltriglycine and [131I]-o-iodohippurate elimination in perfused rat kidney. Nucl Med Biol. 2003;30:45-9 pubmed
    ..47. Both compounds were bound to proteins in the perfusate to a considerable extent. An analysis of renal handling showed that contribution of tubular secretion to the total excretion was 95% for OIH, and 97% for (99m)Tc-MAG3. ..
  22. Taylor A, Lipowska M, Marzilli L. (99m)Tc(CO)3(NTA): a (99m)Tc renal tracer with pharmacokinetic properties comparable to those of (131)I-OIH in healthy volunteers. J Nucl Med. 2010;51:391-6 pubmed publisher
    ..Preliminary results in healthy volunteers suggest that the pharmacokinetic behavior of (99m)Tc(CO)(3)(NTA) is comparable to that of (131)I-OIH. ..
  23. Gellert S, Devaux S, Schönberger B, May G. Donor age and graft function. Pediatr Nephrol. 1996;10:716-9 pubmed
    ..We conclude that graft survival and function in children with either a pediatric or an adult graft may not differ because graft function adapts to the requirement of the recipient. ..
  24. de Vries P, Navis G, de Jong P, de Zeeuw D. Can continuous intraperitoneal infusion of 125I-iothalamate and 131I-hippuran be used for measurement of GFR in conscious rats?. Ren Fail. 1998;20:249-55 pubmed
    ..Thus intraperitoneal infusion of renal function tracers cannot replace intra-arterial infusion. ..
  25. Nielsen S, Poulsen E, Marqversen J, Nielsen L, Bacher T, Rehling M. Clearance and renal extraction of technetium-99m-L,L-ethylenedicysteine, I-131-ortho-iodohippurate and I-125-iothalamate in pigs. Clin Physiol. 1999;19:338-43 pubmed
    ..We conclude that 99mTc-EC is not a suitable tracer for measuring renal function by the single-injection plasma clearance technique in pigs. This is due to a decreasing renal extraction and a significant hepatic clearance. ..
  26. Ammari B, Hotze A, Biltz H, Grunwald F, Kuster W, Biersack H, et al. [Nuclear medicine kidney diagnosis in progressive systemic scleroderma]. Hautarzt. 1991;42:627-30 pubmed
    ..Hippurate clearance is thus a sensitive method of functional renal evaluation in PSS. ..
  27. Zmbova B, Djokic D, Bogdanova V, Tadzer I, Ajdinovic B, Rastovac M. Synthesis of p-aminohippuric acid analog and its labeling by technetium-99m. Int J Rad Appl Instrum A. 1989;40:225-34 pubmed
    ..However, it has slightly slower urinary elimination compared to hippuran, which it makes possible to use PAHIDA as a replacement of hippuran to a certain extent...
  28. el Maghraby T, van Eck Smit B, de Fijter J, Pauwels E. Quantitative scintigraphic parameters for the assessment of renal transplant patients. Eur J Radiol. 1998;28:256-69 pubmed
    ..In addition, no universal agreement on the use of certain quantitation parameters in transplant patients has been reached. ..
  29. Erbslöh Möller B, Dumas A, Roth D, Sfakianakis G, Bourgoignie J. Furosemide-131I-hippuran renography after angiotensin-converting enzyme inhibition for the diagnosis of renovascular hypertension. Am J Med. 1991;90:23-9 pubmed
    ..Furosemide-131I-hippuran renography with ACE inhibition is highly predictive in identifying patients with RVH. ..
  30. Prvulovich E, Bomanji J, Waddington W, Rudrasingham P, Verbruggen A, Ell P. Clinical evaluation of technetium-99m-L,L-ethylenedicysteine in patients with chronic renal failure. J Nucl Med. 1997;38:809-14 pubmed
    ..These features together with its ease of preparation make 99mTc-L,L-EC an attractive alternative to 99mTc-MAG3 in patients with chronic renal failure. ..
  31. Mann S, Pickering T, Sos T, Uzzo R, Sarkar S, Friend K, et al. Captopril renography in the diagnosis of renal artery stenosis: accuracy and limitations. Am J Med. 1991;90:30-40 pubmed
    ..If renograms are obtained both before and after captopril administration, the presence of captopril-induced change is a highly specific finding for the detection of renal artery stenosis, but the sensitivity of this finding is low. ..
  32. Wafelman A, Hoefnagel C, Maessen H, Maes R, Beijnen J. Renal excretion of iodine-131 labelled meta-iodobenzylguanidine and metabolites after therapeutic doses in patients suffering from different neural crest-derived tumours. Eur J Nucl Med. 1997;24:544-52 pubmed
    ..Except for two adult patients, who showed excretion of 14%-18% of [131I]meta-iodohippuric acid ([131I]MIHA), the cumulatively excreted radioactivity consisted of >85% [131I]MIBG, with 6% of the dose ..
  33. Shapiro B, Gonin J, Tuscan M, Wiggins R, Campbell D, Juni J. Demonstration by iodine-131-hippurate renography of a marked sensitivity of some transplanted kidneys to volume contraction. Am J Physiol Imaging. 1989;4:1-3 pubmed
    ..These findings demonstrate a greater sensitivity to dehydration of some transplanted kidneys when compared to normal kidneys. ..
  34. Miserez A. [The value of combined computer-aided perfusion scintigraphy and renography in renal transplant patients with oliguria/anuria]. Nuklearmedizin. 1989;28:100-12 pubmed
    ..001). As a non-invasive examination which can also be carried out in emergency cases, combined computer-aided perfusion scintigraphy and renography should become part of standard diagnostic procedures for oligo/anuric graft recipients. ..
  35. Fukuchi M, Ishimura J, Komatani A, Kera M, Sasaki Y, Oriuchi N, et al. [A phase III multi-center clinical trial on 123I-orthoiodohippurate (123I-OIH)]. Hinyokika Kiyo. 1990;36:371-82 pubmed
    ..These results suggest that 123I-OIH is superior to 131I-OIH and equal or superior to 99mTc-DTPA as a radiopharmaceutical for gamma camera-renography. ..
  36. Thomsen H, Hvid Jacobsen K, Meyhoff H, Nielsen S. Combination of DMSA-scintigraphy and hippuran renography in unilateral obstructive nephropathy. Improved prediction of recovery after intervention. Acta Radiol. 1987;28:653-5 pubmed
    ..Use of the two radiopharmaceuticals, thus, may have great impact on the clinical decision, since in case of a difference some function may be saved by immediate intervention. ..
  37. Mortensen J, Christiansen P, Harving N, Taagehøj Jensen F, Djurhuus J. Pyeloureteral dynamics. Pelvic pressure and kidney function in partial long-term ureteric obstruction. Scand J Urol Nephrol. 1989;23:25-9 pubmed
    ..This clearly indicates, that the pelvic pressure at normal urine flow rate is an important factor in the pathogenesis of obstructive nephropathy. ..
  38. Stoffel M, Jamar F, Van Nerom C, Verbruggen A, Mourad M, Leners N, et al. Evaluation of technetium-99m-L,L-EC in renal transplant recipients: a comparative study with technetium-99m-MAG3 and iodine-125-OIH. J Nucl Med. 1994;35:1951-8 pubmed
    ..This tracer is safe and suitable for both imaging and quantitative measurement of the renal tubular function. Technetium-99m-L,L-EC represents an excellent alternative to 99mTc-MAG3. ..
  39. Misra M, Das B, Gambhir S, Mittal B, Sewatkar A, Ghosh S, et al. Clinical evaluation of Tc-99m cystine. A new renal radiopharmaceutical. Clin Nucl Med. 1994;19:446-51 pubmed
    ..The clearance values also have been compared with I-131 OIH clearance. The results show that Tc-99m cystine has good radiopharmaceutical characteristics suitable for evaluation of both renal function as well as morphology. ..
  40. Indovina A. [Mean renal transit time of I-123 orthoiodohippurate in normotensive and hypertensive subjects]. Clin Ter. 1996;147:47-50 pubmed
    ..The author explains this observation saying that in the tested hypertensive subjects the turnover of the I-123-orthoiodohippurate is increased. ..
  41. Barceló Oliver M, Garcia Raso A, Terron A, Molins E, Prieto M, Moreno V, et al. Synthesis and mass spectroscopy kinetics of a novel ternary copper(II) complex with cytotoxic activity against cancer cells. J Inorg Biochem. 2007;101:649-59 pubmed
    The X-ray structure of the [Cu(I-hip)(phen)2](+).(I-hip-).(H2O)7 complex (1) (where I-hipH is referred to o-iodohippuric acid and phen is 1,10-phenanthroline) and its binary synthetic intermediate [Cu(I-hip)2(H2O)3]...
  42. Kotzerke J, Burchert W, Wiese H, von Smekal U, Hundeshagen H. Limitations of clearance determination using the single sample distribution volume method. An error analysis on the basis of compartment models. Eur J Nucl Med. 1992;19:19-24 pubmed
    ..Whilst it can be used preferably in healthy, normal-weight adults, it is not applicable, without error, under all other circumstances...
  43. de Zeeuw D, Jonker G, Hovinga T, Beekhuis H, Piers D, Huisman R, et al. The mechanism and diagnostic value of angiotensin I converting enzyme inhibition renography. Am J Hypertens. 1991;4:741S-744S pubmed
    ..In conclusion, in an ideal setting as obtained in animal experiments, ACE inhibition improves the sensitivity of renographic studies to 100%. However, its value in the clinical setting needs more standardization...
  44. Prenen J, de Klerk J, van het Schip A, van Rijk P. Technetium-99m-MAG3 versus iodine-123-OIH: renal clearance and distribution volume as measured by a constant infusion technique. J Nucl Med. 1991;32:2057-60 pubmed
    ..4 and 70.2% for MAG3 and OIH, respectively. This investigation revealed some significant differences in the normal values of the renal clearance and distribution volume of MAG3 compared with other studies...
  45. Cleator G, Klapper P, Lewis A, Sharma H, Smith A. Measurement of renal blood flow by 131I-labelled sodium iodohippurate imaging in a rat model of herpes encephalitis. Acta Radiol. 1990;31:538-9 pubmed
    ..Our data suggest that kidney function is not compromised in this animal model of encephalitis. The results are discussed in the context of the development of a non-invasive protocol for the in vivo diagnosis of herpes encephalitis...
  46. Ishii K, Tadokoro K, Nishimaki H, Nakazawa K, Matsubayashi T, Ishibashi A, et al. [Clinical evaluation of renoscintigraphy using 123I-orthoiodohippurate--comparison with 131I-OIH and measurement of the effective renal blood flow]. Nihon Igaku Hoshasen Gakkai Zasshi. 1990;50:68-75 pubmed
    ..It is concluded that 123I-OIH is a useful radiopharmaceutical for renal examination, and it should replace 131I-OIH...
  47. McAfee J, Thomas F, Subramanian G, Roskopf M, Hellwig B. Evaluation of cyclosporine nephrotoxicity in rats with various renal radioactive agents. J Nucl Med. 1988;29:1577-81 pubmed
    ..This conclusion is consistent with previous studies which showed a parallel decline in glomerular filtration rate (GFR) and effective renal plasma flow in acute CyA toxicity probably due primarily to vasoconstriction...
  48. Carlsen O, Nathan E. Glomerular filtration rate in adults estimated from 123iodine-hippuran and 99mtechnetium-diethylenetriaminepenta-acetic acid gamma camera renography. Clin Physiol. 1988;8:399-406 pubmed
    ..73 m2, respectively. The corresponding SD in TDGR were about 7 and 11 ml/min/1.73 m2. These standard deviations are sufficiently small for many clinical purposes and the method requires no blood samples or urine collections...
  49. Puchal R, Pavia J, Gonzalez A, Ros D. Optimal filtering values in renogram deconvolution. Phys Med Biol. 1988;33:831-45 pubmed
    ..The study was carried out simulating the input and output curves which would be obtained when using hippuran and DTPA as tracers...
  50. Apperloo A, de Zeeuw D, Donker A, de Jong P. Precision of glomerular filtration rate determinations for long-term slope calculations is improved by simultaneous infusion of 125I-iothalamate and 131I-hippuran. J Am Soc Nephrol. 1996;7:567-72 pubmed
    ..It is concluded that the precision of GFR measurements is improved by using correction for inaccurate urine collection with concomitant 131I-hippuran clearance...
  51. Yenrudi S, Laohapaibul A, Kittidiwit W, Suteparuk S, Futrakul N. A correlation between renal morphology and renal circulation in pediatric nephrotic syndrome. Ren Fail. 2001;23:85-90 pubmed
    ..In respect to the glomerular study, the incidence of glomerulosclerosis increased as the renal perfusion decreased, however, the correlation did not reach a statistical significance...
  52. Yabuki M. [Change of joint synovial clearance speed in experimental arthritis]. Ryumachi. 1991;31:4-13 pubmed
  53. Hupp T, Clorius J, Allenberg J. Renovascular hypertension: predicting surgical cure with exercise renography. J Vasc Surg. 1991;14:200-7 pubmed
    ..In comparison, blood pressure values were little influenced by therapy in patients with an abnormal response, where 17 of 19 patients continued to have hypertensive disease after therapy.(ABSTRACT TRUNCATED AT 250 WORDS)..
  54. Frøkiaer J, Jensen F, Djurhuus J, Christiansen P, Harving N, Mortensen J. The impact of unilateral ureteral obstruction on pelvic and parenchymal transit times in the pig kidney. Eur J Nucl Med. 1990;16:349-52 pubmed
    ..The study suggests that interpretation of the obstructed renogram will encounter analysis of both parenchymal and pelvic transit times in cases where renal function is moderately reduced...
  55. Hofmann W, Gabriel R, Rumohr T. [Diagnostic value of radioisotope clearance in patients with a single kidney]. Z Urol Nephrol. 1990;83:61-5 pubmed
    ..In the present study of dynamic radioisotope investigations in patients with solitar kidney could be verified...
  56. Zietse R, Blankestijn P, Pos B, Balk A, Derkx F, Weimar W, et al. Optimising glomerular filtration rate and effective renal plasma flow measurements using a simple pharmacokinetic model. Clin Nephrol. 1995;43:29-34 pubmed
    ..In these patients, GFR should be measured using a method that is not dependent on urine collection. Also, the estimation of GFR by means of Cockcrofts equation seems to underestimate GFR in diabetic subjects...
  57. Russell C, Dubovsky E. Comparison of single-injection multisample renal clearance methods with and without urine collection. J Nucl Med. 1995;36:603-6 pubmed
    ..In this study, we compare urine-based and urine-free methods for the tubular agents 99mTc-MAG3 and 131I-OIH...
  58. Turpin S, Lambert R, Milot A, Taillefer R, Leveille J, Lefebvre B. A physiologic approach to renal scintigraphy. Application to evaluation of hypertension. Clin Nucl Med. 1995;20:206-10 pubmed
    ..6-2.0 ml/g/minute, GFR = 0.25-0.4 ml/g/minute, and filtration fraction (i.e., GFR/ERPF = 0.15-0.20) on the affected side...
  59. Komai S, Toyama H, Takeuchi A, Yokoyama K, Koga S. [Quantitative analysis of individual renal function using 99mTc-DMSA scintigram--comparison with 131I-OIH renogram]. Kaku Igaku. 1995;32:427-33 pubmed
    ..In conclusion, quantitative analysis of individual renal function using DMSA uptake ratio is considered to be useful to evaluate the renal functional reserve...
  60. Boubaker A, Meyrat B, Frey P, Bischof Delaloye A. Unilateral urinary flow impairment at the pelviureteral junction: outcome of renal function with respect to therapeutic strategy. Urology. 2003;61:1224-8; discussion 1228-9 pubmed
    ..To evaluate the renal function outcome in children with unilateral hydronephrosis and urinary flow impairment at the pelviureteral junction with respect to the therapeutic strategy...
  61. Blaufox M, Dubovsky E, Hilson A, Taylor A, De Zeeuw R. Report of the Working Party Group on Determining the Radionuclide of Choice. Am J Hypertens. 1991;4:747S-748S pubmed
    ..Considerations of cost, ease of use, reliability, dosage, and the effects of different protocols were all examined...
  62. Russell C, Dubovsky E, Scott J. Simplified methods for renal clearance in children: scaling for patient size. J Nucl Med. 1991;32:1821-5 pubmed
    ..Inclusion of pediatric data improves the fit and permits development of generic methods that work with both adults and children...
  63. Shirasaka K. [Clinical study of nephrotoxicity following cis-diamminedichloroplatinum (II) (CDDP) combination chemotherapy assessed by 131I-OIH renogram]. Nihon Igaku Hoshasen Gakkai Zasshi. 1990;50:1580-9 pubmed
    ..131I-OIH or 123I-OIH renogram in delayed phase is useful for detection of renal dysfunction by CDDP administration...
  64. Kremer Hovinga T, de Jong P, Piers D, Beekhuis H, van der Hem G, de Zeeuw D. Diagnostic use of angiotensin converting enzyme inhibitors in radioisotope evaluation of unilateral renal artery stenosis. J Nucl Med. 1989;30:605-14 pubmed
    ..Despite a large drop in blood pressure after ACE inhibition little adverse reactions were seen and overall renal function was fairly well maintained, the exceptions noted in patients with initially a more impaired renal function...
  65. Russell C, Dubovsky E, Scott J. Estimation of ERPF in adults from plasma clearance of 131I-hippuran using a single injection and one or two blood samples. Int J Rad Appl Instrum B. 1989;16:381-3 pubmed
    ..Since the one-sample method is satisfactory for most clinical purposes, the two-sample method is recommended only when special accuracy is needed...
  66. Nakashima R, Tomiguchi S, Kojima A, Takaki Y, Tsuji A, Takahashi M. Measurement of effective renal plasma flow (ERPF) with 123I-orthoiodohippurate (I-123-OIH). Radiat Med. 1996;14:147-50 pubmed
    ..816). In conclusion, attenuation correction for renal uptake is an important technique for estimating ERPF using I-123-OIH renal scintigraphy...
  67. Fine E. Interventions in renal scintirenography. Semin Nucl Med. 1999;29:128-45 pubmed
    ..Finally, further investigations of exercise renography in essential hypertension have deepened the plausibility of a renal role in the etiology of perhaps 50% of affected individuals...
  68. Nortier J, Wautrecht J, Delcour C, Schoutens A, Dereume J. Role of the captopril test in renovascular hypertension: a case report. Angiology. 1992;43:939-45 pubmed
    ..The results of renographic studies obtained in this clinical case underline the role of the captopril radionuclide test in detection and follow-up after treatment of renovascular hypertension...
  69. Sfakianakis G, Bourgoignie J. Renographic diagnosis of renovascular hypertension with angiotensin converting enzyme inhibition and furosemide. Am J Hypertens. 1991;4:706S-710S pubmed
    ..We look forward to the future development of this technique...
  70. Fukuchi M, Ishimura J, Yamashita M, Ishihara K, Matsui R, Kanegawa K, et al. [Clinical evaluation of 123I-orthoiodohippurate (123I-OIH) for diagnosis of renal function: dose finding study]. Hinyokika Kiyo. 1990;36:197-205 pubmed
    ..abstract truncated at 250 words)..
  71. Fletcher D, Braslis K, Shulkes A, Hardy K. Calcitonin gene related peptide: vasodilator in ovine hepatic and renal vasculature. Clin Exp Pharmacol Physiol. 1990;17:467-76 pubmed
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    ..To differentiate acute tubular necrosis from acute rejection when it occurs in the early posttransplant period is difficult. Renal scintigraphy offers a noninvasive means for renal blood flow (RBF) and renal function assessment...
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    ..His creatinine was 1.6 mg/dl on admission but demonstrated appropriate renal function on subsequent noncaptopril renal scintigraphy...
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    ..When the RKFs are asymmetric to a greater extent, the correction should be performed for each study separately. The proposed method includes a small systematic error due to the inherent limitations of nuclear medicine equipment...
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    ..Extrarenal clearance of 99mTc-MAG3 is relatively smaller than extrarenal clearance of 51Cr-EDTA. Thus, plasma clearance of 99mTc-MAG3 can be used as a measure of renal tubular function...
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    ..Quantitative radionuclide studies of the kidneys provide comprehensive, reproducible, and objective assessments of renal function...
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    ..73 m2 (range 144.4 to 746.5 ml/min/1.73 m2) and highly correlated with RPFPAH (r = 0.883, p less than 0.0001). This technique permits prolonged studies of renal plasma flow under steady-state conditions without constant infusion...
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    ..Absolute ERPF value was higher with MAG3, but the correlation index (r = 0.98) allowed a simple correction factor to be introduced. In conclusion, MAG3 appears to be a good alternative to OIH...
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    ..This article evaluates the clinical usefulness of 99mTc-ethylenedicysteine (EC) in patients with various renal disorders. In addition, extraction ratios of 99mTc-EC in five volunteers were also determined...
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    ..The objective of this study was to compare renogram parameters of [(18)F]PFH with o-[(125)I]iodohippurate ([(125)I]OIH) as a surrogate for the renal imaging gold standard (131)I-OIH and with a clinically used agent [(99m)Tc]MAG3...
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    ..These data differ from reports from other centers, perhaps due to differences in renography methods, criteria for interpretation of renography, and/or patient selection criteria...
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    ..005) and need for hemodialysis (p = 0.007). We recommend this grading system as a simple and accurate method to interpret orthoiodohippurate renal scans in the evaluation and followup of renal allograft recipients...
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