p aminohippuric acid


Summary: The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.

Top Publications

  1. Osei S, Price D, Fisher N, Porter L, Laffel L, Hollenberg N. Hyperglycemia and angiotensin-mediated control of the renal circulation in healthy humans. Hypertension. 1999;33:559-64 pubmed
    ..PRA did not change with hyperglycemia. Enhancement of renal vasodilation during hyperglycemia by captopril without alteration of PRA suggests activation of the intrarenal renin angiotensin system...
  2. Kang A, Duncan J, Cattran D, Floras J, Lai V, Scholey J, et al. Effect of oral contraceptives on the renin angiotensin system and renal function. Am J Physiol Regul Integr Comp Physiol. 2001;280:R807-13 pubmed
    ..We conclude that the RAS is activated in women using OCs. There was no evidence that decreases in renin secretion result in normalization of the RAS as a whole...
  3. Cherney D, Scholey J, Cattran D, Kang A, Zimpelmann J, Kennedy C, et al. The effect of oral contraceptives on the nitric oxide system and renal function. Am J Physiol Renal Physiol. 2007;293:F1539-44 pubmed
    ..04). In summary, these findings suggest that the NO system is upregulated by OC use in young, healthy women. Increased activity of the NO pathway may modulate the hemodynamic effects of RAS activation in OC users...
  4. Petersen J, Christensen S. Superiority of tetraethylammonium to p-aminohippurate as a marker for renal plasma flow during furosemide diuresis. Ren Physiol. 1987;10:102-9 pubmed
    ..A similar effect was observed after administration of probenecid. The results indicate that TEA is a more reliable indicator of RPF than PAH in studies involving accumulation of endogenous or exogenous organic anions...
  5. Vierhapper H, Gasic S, Roden M, Waldhausl W. Increase in skeletal muscle blood flow but not in renal blood flow during euglycemic hyperinsulinemia in man. Horm Metab Res. 1993;25:438-41 pubmed
    ..The observed dissociation of ERPF and ELPF suggests a differential response to insulin in renal vs. leg vasculature which possibly is due to increased peripheral glucose metabolism. ..
  6. Zalups R, Ahmad S. Handling of cysteine S-conjugates of methylmercury in MDCK cells expressing human OAT1. Kidney Int. 2005;68:1684-99 pubmed
  7. Zhang J, Massmann G, Rose J, Figueroa J. Differential effects of clinical doses of antenatal betamethasone on nephron endowment and glomerular filtration rate in adult sheep. Reprod Sci. 2010;17:186-95 pubmed publisher
    ..Our data thus support the conclusion that exposure to glucocorticoids at a time of rapid kidney growth is associated with an elevation in blood pressure that does not appear related solely to the reduction in nephron number. ..
  8. Valentovic M, Ball J, Elliott C, Madan E. Cephaloridine nephrotoxicity in streptozotocin induced diabetic Fischer 344 (F344) rats. Toxicology. 1989;57:193-207 pubmed
    ..05) in the normoglycemic group at 24-72 h. No change in kidney wt, PAH or TEA uptake was observed in the diabetic rats. These data indicate diabetes reduces cephaloridine nephrotoxicity. ..
  9. Gossmann J, Radounikli A, Bernemann A, Schellinski O, Raab H, Bickeböller R, et al. Pathophysiology of cyclosporine-induced nephrotoxicity in humans: a role for nitric oxide?. Kidney Blood Press Res. 2001;24:111-5 pubmed
    ..1 and 0.05). The pathophysiology of CsA-induced acute renal vasoconstriction involves several different mechanisms including a decrease of the vasodilating prostaglandins E2 and 6-keto-prostaglandin F(1 alpha) and possibly nitric oxide. ..

More Information

Publications106 found, 100 shown here

  1. Ida S, Yokota M, Ueoka M, Kiyoi K, Takiguchi Y. Mild to severe lithium-induced nephropathy models and urine N-acetyl-beta-D-glucosaminidase in rats. Methods Find Exp Clin Pharmacol. 2001;23:445-8 pubmed
    ..When the urine NAG level becomes high in a patient taking lithium for bipolar disorder, the physician may need to consider lithium-induced renal insufficiency. ..
  2. Torres A, MacLaughlin M, Quaglia N, Stremmel W. Role of BSP/bilirubin binding protein on p-aminohippurate transport in rat kidney. Mol Cell Biochem. 2003;245:149-56 pubmed
    ..Western blot studies revealed positivity to antiBBBP antibodies in both BBMV and BLMV. So BBBP is also expressed in the kidneys and accounts, at least in part, for the renal tubular transport of PAH. ..
  3. Fujita T, Brown C, Carlson E, Taylor T, De La Cruz M, Johns S, et al. Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Pharmacogenet Genomics. 2005;15:201-9 pubmed
  4. Jin X, Lok E, Caldwell D, Mueller R, Kapal K, Liston V, et al. Dietary fats altered nephrotoxicity profile of methylmercury in rats. J Appl Toxicol. 2009;29:126-40 pubmed publisher
    ..These results confirmed that kidney tubules are major targets of MeHg nephrotoxicity. Treatment with dietary fats did not prevent, but rather altered the profile of, nephrotoxicity of MeHg in rats. ..
  5. Farthing D, Sica D, Fakhry I, Larus T, Ghosh S, Farthing C, et al. Simple HPLC-UV method for determination of iohexol, iothalamate, p-aminohippuric acid and n-acetyl-p-aminohippuric acid in human plasma and urine with ERPF, GFR and ERPF/GFR ratio determination using colorimetric analysis. J Chromatogr B Analyt Technol Biomed Life Sci. 2005;826:267-72 pubmed
    ..The method was utilized in several different clinical studies evaluating the effect of kidney function from medications (phase IV evaluations) marketed for patients with cardiovascular disease...
  6. Eraly S, Vallon V, Vaughn D, Gangoiti J, Richter K, Nagle M, et al. Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice. J Biol Chem. 2006;281:5072-83 pubmed
    ..We have also demonstrated in xenopus oocytes that some of these compounds interact with OAT1 in vitro. Thus, these latter compounds might represent physiological substrates of OAT1. ..
  7. Uchino H, Tamai I, Yamashita K, Minemoto Y, Sai Y, Yabuuchi H, et al. p-aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1. Biochem Biophys Res Commun. 2000;270:254-9 pubmed
    ..This is the first molecular demonstration of an organic anion transport function for PAH at the renal apical membrane. ..
  8. Hill G, Cihlar T, Oo C, Ho E, Prior K, Wiltshire H, et al. The anti-influenza drug oseltamivir exhibits low potential to induce pharmacokinetic drug interactions via renal secretion-correlation of in vivo and in vitro studies. Drug Metab Dispos. 2002;30:13-9 pubmed
    ..The study results demonstrate that oseltamivir has a low drug-drug interaction potential at the renal tubular level due to inhibition of hOAT1. ..
  9. Kwon O, Hong S, Blouch K. Alteration in renal organic anion transporter 1 after ischemia/reperfusion in cadaveric renal allografts. J Histochem Cytochem. 2007;55:575-84 pubmed
    ..This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials. ..
  10. Gonzalez Alvarez I, Fernández Teruel C, Casabó Alós V, Garrigues T, Polli J, Ruiz Garcia A, et al. In situ kinetic modelling of intestinal efflux in rats: functional characterization of segmental differences and correlation with in vitro results. Biopharm Drug Dispos. 2007;28:229-39 pubmed
    ..The successful application of a model approach to combine absorption data from two different experimental systems holds promise for future efforts to predict absorption results from one system to a second system. ..
  11. Bresler V, Valter S, Jerebtsova M, Isayev Ivanov V, Kazbekov E, Kleiner A, et al. The influence of the lipid bilayer phase state on the p-aminohippurate (PAH) transport and the activity of the alkaline phosphatase in brush-border membrane vesicles from normal and mutant rats. Biochim Biophys Acta. 1989;982:288-94 pubmed
    ..We suppose that mutation in the Campbell strain gives rise to a membrane pleiotropic effect which enables us to understand the mechanism of genetic control of the lipid structure and membrane fluidity...
  12. Jensen R, Berndt W. Epinephrine and norepinephrine enhance p-aminohippurate transport into basolateral membrane vesicles. J Pharmacol Exp Ther. 1988;244:543-9 pubmed
    ..Activation of Na+-K+-adenosine triphosphatase is a possible mechanism whereby adrenergic agonists may exert effects on Na+-coupled transport across the basolateral membrane...
  13. Imaoka T, Kusuhara H, Adachi Akahane S, Hasegawa M, Morita N, Endou H, et al. The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules. J Am Soc Nephrol. 2004;15:2012-22 pubmed
    ..In addition to the kidney, mouse RST was detected in the brain capillaries and the choroid plexus, and it may also play a role in efflux transport of organic anions across the barriers of the central nervous system. ..
  14. Kiguchi M, Sudo J. Comparative study of colorimetric method using diazotization reaction and high-performance liquid chromatographic method in determination of para-aminohippuric acid. J Toxicol Sci. 1987;12:301-7 pubmed
    ..In addition, our HPLC method is considered to be applicable to microassay of PAH, because its sensitivity is more sensitive and minimization of volume system is more easily achieved as compared with the colorimetric method...
  15. Gore D, Dalton J, Gehr T. Colloid infusions reduce glomerular filtration in resuscitated burn victims. J Trauma. 1996;40:356-60 pubmed
    ..Furthermore, this study demonstrates that hormonal regulation of blood volume remains intact after moderate burn injury. ..
  16. Trolliet M, Rudd M, Loscalzo J. Oxidative stress and renal dysfunction in salt-sensitive hypertension. Kidney Blood Press Res. 2001;24:116-23 pubmed
    ..bioavailability may represent a common factor responsible for the vascular and glomerular dysfunction. ..
  17. Kikuchi R, Kusuhara H, Abe T, Endou H, Sugiyama Y. Involvement of multiple transporters in the efflux of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors across the blood-brain barrier. J Pharmacol Exp Ther. 2004;311:1147-53 pubmed
    ..The results of the present study suggest the involvement of multiple transporters, including rOat3 and rOatp2, in the efflux transport of pravastatin and pitavastatin across the BBB, each making a different contribution. ..
  18. Schneider R, Sauvant C, Betz B, Otremba M, Fischer D, Holzinger H, et al. Downregulation of organic anion transporters OAT1 and OAT3 correlates with impaired secretion of para-aminohippurate after ischemic acute renal failure in rats. Am J Physiol Renal Physiol. 2007;292:F1599-605 pubmed
    ..As a result, this may have substantial impact on excretion kinetics and half-life of organic anions. As a consequence, the biological effects of a variety of organic anions may be affected after iARF. ..
  19. Ueo H, Motohashi H, Katsura T, Inui K. Cl- -dependent upregulation of human organic anion transporters: different effects on transport kinetics between hOAT1 and hOAT3. Am J Physiol Renal Physiol. 2007;293:F391-7 pubmed
    ..It was suggested that Cl(-) participates in the trans-location process for hOAT1, and the substrate recognition process for hOAT3. ..
  20. Cirio A, Boivin R. [Renal extraction of para-aminohippurate and inulin from sheep on low-protein diets]. Ann Rech Vet. 1990;21:167-70 pubmed
    ..Thus, the reduction in renal plasma flow (PAH clearance), induced by low protein rations, is not dependent on any change in PAH extraction. This reduction is probably responsible for the simultaneous decrease of glomerular filtration...
  21. Berg U. Differences in decline in GFR with age between males and females. Reference data on clearances of inulin and PAH in potential kidney donors. Nephrol Dial Transplant. 2006;21:2577-82 pubmed
    ..Males showed a significant decrease between 20 and 50 years of age, which was not seen in females. Females seem to be protected in the pre-menopausal period probably by oestrogens. These results confirm clinically those found in rats. ..
  22. Eisner C, Faulhaber Walter R, Wang Y, Leelahavanichkul A, Yuen P, Mizel D, et al. Major contribution of tubular secretion to creatinine clearance in mice. Kidney Int. 2010;77:519-26 pubmed publisher
    ..Hence we show that there is a major secretory contribution to creatinine excretion mediated through the organic anion transport system. This feature adds to problems associated with measuring endogenous creatinine filtration in mice. ..
  23. Furuya K, Durie P, Roberts E, Soldin S, Verjee Z, Yung Jato L, et al. Glycine conjugation of para-aminobenzoic acid (PABA): a quantitative test of liver function. Clin Biochem. 1995;28:531-40 pubmed
    ..To evaluate glycine conjugation of para-aminobenzoic acid (PABA) to the hippurated metabolites, para-aminohippuric acid (PAHA), and para-acetamidohippuric acid (PAAHA) as a quantitative liver function test in patients with liver disease...
  24. Breen C, Sykes D, Fricker G, Miller D. Confocal imaging of organic anion transport in intact rat choroid plexus. Am J Physiol Renal Physiol. 2002;282:F877-85 pubmed
  25. Agarwal R, Vasavada N, Chase S. Liquid chromatography for iothalamate in biological samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2003;785:345-52 pubmed
    ..There was excellent thermal and pH stability of iothalamate. No interference was found with para-amino hippuric acid (PAH) or N-acetyl PAH, which can be simultaneously assayed, if desired. ..
  26. Kobayashi Y, Shibusawa A, Saito H, Ohshiro N, Ohbayashi M, Kohyama N, et al. Isolation and functional characterization of a novel organic solute carrier protein, hOSCP1. J Biol Chem. 2005;280:32332-9 pubmed
    ..Our results suggest that hOSCP1 is a novel polyspecific organic solute carrier protein responsible for drug clearance from the human placenta. ..
  27. Hoskin S, Savary Auzeloux I, Calder A, Zuur G, Lobley G. Effect of feed intake on amino acid transfers across the ovine hindquarters. Br J Nutr. 2003;89:167-79 pubmed
    ..Nutritional or other strategies to enhance AA transport into peripheral tissues are unlikely to increase anabolic responses. ..
  28. Kwon O, Kwon H, Hong S, Goldinger J. Size selected mRNA induces expression of P-aminohippurate transport in Xenopus oocytes. Proc Soc Exp Biol Med. 1989;192:205-8 pubmed
    ..The uptake of PAH was unaffected by the absence of Na+ or the presence of probenecid. Expression of the transport represents the first step in an effort to clone and identify the gene for PAH transport...
  29. Wolff N, Grünwald B, Friedrich B, Lang F, Godehardt S, Burckhardt G. Cationic amino acids involved in dicarboxylate binding of the flounder renal organic anion transporter. J Am Soc Nephrol. 2001;12:2012-8 pubmed
    ..These data suggest that amino acids K394 and R478 in fROAT are required for dicarboxylate binding and PAH/dicarboxylate exchange. ..
  30. Kolb R, Ghazi A, Barfuss D. Inhibition of basolateral transport and cellular accumulation of cDDP and N-acetyl- L-cysteine-cDDP by TEA and PAH in the renal proximal tubule. Cancer Chemother Pharmacol. 2003;51:132-8 pubmed
    ..It is concluded that a PAH-sensitive organic anion transporter is involved in the accumulation of NAC-cDDP at the basolateral membrane and a TEA-sensitive organic cation transport system is involved in the accumulation of free cDDP. ..
  31. Severin M, Hazelhoff M, Bulacio R, Mamprin M, Brandoni A, Torres A. Impact of the induced organic anion transporter 1 (Oat1) renal expression by furosemide on the pharmacokinetics of organic anions. Nephrology (Carlton). 2017;22:642-648 pubmed publisher
    ..Because of furosemide worldwide use, the data obtained are interesting and useful in terms of translation to clinical practice. ..
  32. Gloff C, Mamelok R, Benet L. Organic anion transport by basal-lateral membranes: effect of PAH and furosemide on each other's transport. Pharmacology. 1988;37:268-76 pubmed
    ..The data suggest that PAH and furosemide are transported by a common carrier-mediated process in the proximal tubule of the rabbit kidney...
  33. Knight R, Bowmer C, Yates M. The diuretic action of 8-cyclopentyl-1,3-dipropylxanthine, a selective A1 adenosine receptor antagonist. Br J Pharmacol. 1993;109:271-7 pubmed
    ..Furthermore, the results provide evidence that production and release of endogenous adenosine modifies renal excretory function via stimulation of the A1 receptor subtype. ..
  34. Zalups R, Aslamkhan A, Ahmad S. Human organic anion transporter 1 mediates cellular uptake of cysteine-S conjugates of inorganic mercury. Kidney Int. 2004;66:251-61 pubmed
    ..Moreover, these data indicate that the organic anion transporter(s) likely play a prominent role in the basolateral transport of mercuric ions by proximal tubular cells and in the nephropathy induced by Hg(2+). ..
  35. Wang J, Nation R, Evans A, Cox S. Renal secretion of the antiviral nucleoside analog AM188 is inhibited by probenecid, p-aminohippuric acid, and cimetidine in the isolated perfused rat kidney. Pharm Res. 2004;21:982-8 pubmed
    ..33 +/- 0.21* when the concentration of nitrobenzylthioinosine was 5 microM. These results suggest that renal tubular secretion of AM188 involves organic anion and cation transport systems. ..
  36. Weiss P, Lorbeer G, Scharf S. Regional aspects and statistical characterisation of the load with semivolatile organic compounds at remote Austrian forest sites. Chemosphere. 2000;40:1159-71 pubmed
    ..Partly, these different patterns were related to significantly higher or lower corresponding absolute concentrations of the sites. ..
  37. Kikuchi R, Kusuhara H, Sugiyama D, Sugiyama Y. Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier. J Pharmacol Exp Ther. 2003;306:51-8 pubmed
    ..These results suggest that rOat3 is responsible for the elimination of PAH and PCG from the brain across the BBB. ..
  38. Ruiz Jimenez J, Mata Granados J, Luque de Castro M. On-line automatic SPE-CE coupling for the determination of biological markers in urine. Electrophoresis. 2007;28:789-98 pubmed
    ..The accuracy of the method and potential matrix effects were studied by using spiked samples and recoveries between 96.00 and 103.07 % were obtained. The proposed method was applied to samples from healthy young students. ..
  39. Groves C, Nowak G, Morales M. Ochratoxin A secretion in primary cultures of rabbit renal proximal tubule cells. J Am Soc Nephrol. 1999;10:13-20 pubmed
  40. Edwards R, Stack E, Trizna W. Transport of [3H]losartan across isolated perfused rabbit proximal tubule. J Pharmacol Exp Ther. 1999;290:38-42 pubmed
    ..These results demonstrate that losartan and probably other nonpeptide angiotensin II receptor antagonists are secreted by an organic anion transporter that is similar to, if not identical with, the classic PAH transporter...
  41. Chatsudthipong V, Jutabha P. Effect of steviol on para-aminohippurate transport by isolated perfused rabbit renal proximal tubule. J Pharmacol Exp Ther. 2001;298:1120-7 pubmed
    ..The present study clearly showed that steviol can have a direct inhibitory effect on renal tubular transport by competitive binding with organic anion transporter...
  42. Bahn A, Knabe M, Hagos Y, Rödiger M, Godehardt S, Graber Neufeld D, et al. Interaction of the metal chelator 2,3-dimercapto-1-propanesulfonate with the rabbit multispecific organic anion transporter 1 (rbOAT1). Mol Pharmacol. 2002;62:1128-36 pubmed
    ..In summary, rbOAT1 mediates basolateral uptake of DMPS into proximal tubule cells, implicating this process in the detoxification process of heavy metals in the kidneys...
  43. Itagaki S, Chiba M, Shimamoto S, Sugawara M, Kobayashi M, Miyazaki K, et al. Characterization of secretory intestinal transport of phenolsulfonphthalein. Drug Metab Pharmacokinet. 2005;20:72-8 pubmed
    ..These results suggest that PSP is secreted into the intestinal lumen by Mrp2-like transporter and that two Mrp2 substrates, PSP and pravastatin, are likely to be transported by different transport systems at the mucosal membrane...
  44. Matsuo Y, Yano I, Habu Y, Katsura T, Hashimoto Y, Inui K. Transport of levofloxacin in the OK kidney epithelial cell line: interaction with p-aminohippurate transport. Pharm Res. 2001;18:573-8 pubmed
    ..To evaluate the mechanism of renal transport of quinolone antibacterial drugs, we examined the interaction of levofloxacin with p-aminohippurate (PAH) transport systems and the transport of levofloxacin in renal epithelial cells...
  45. Grassl S. Facilitated diffusion of urate in avian brush-border membrane vesicles. Am J Physiol Cell Physiol. 2002;283:C1155-62 pubmed
    ..These observations suggest a uniporter-mediated facilitated diffusion of urate as a pathway for passive efflux across the brush border membrane of urate-secreting proximal tubule cells...
  46. Ohtsuki S, Asaba H, Takanaga H, Deguchi T, Hosoya K, Otagiri M, et al. Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain. J Neurochem. 2002;83:57-66 pubmed
    ..Therefore, inhibition of the brain-to-blood transport involving OAT3 would occur in uremia and lead to the accumulation of neurotransmitter metabolites and drugs in the brain...
  47. Perrin N, Torbjörnsdotter T, Jaremko G, Berg U. The course of diabetic glomerulopathy in patients with type I diabetes: a 6-year follow-up with serial biopsies. Kidney Int. 2006;69:699-705 pubmed
    ..In conclusion, the morphological parameters deteriorated in the normoalbuminuric patients and in those with complications, but were unchanged in the small antihypertensive-treated group with improved metabolic control...
  48. Jin M, Han H. Interaction of zalcitabine with human organic anion transporter 1. Pharmazie. 2006;61:491-2 pubmed
    ..Those results suggest that hOATI contributes at least in part to the cellular uptake of zalcitabine across the basolateral membrane of proximal tubular cells...
  49. Cristofori P, Zanetti E, Fregona D, Piaia A, Trevisan A. Renal proximal tubule segment-specific nephrotoxicity: an overview on biomarkers and histopathology. Toxicol Pathol. 2007;35:270-5 pubmed
  50. Han P, Shaw P, Kirkpatrick C. Determination of para-aminohippuric acid (PAH) in human plasma and urine by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009;877:3215-20 pubmed publisher
  51. Preuss H, Razavi M, Slemmer D, Zein M. Colorimetry of p-aminohippurate in the presence of sulfamethoxazole. Clin Chem. 1988;34:422-3 pubmed
    ..We found that isoamyl acetate removes sulfamethoxazole from the samples without influencing PAH. The extraction is simple, inexpensive, and reproducible...
  52. Burckhardt B, Wolff N, Burckhardt G. Electrophysiologic characterization of an organic anion transporter cloned from winter flounder kidney (fROAT). J Am Soc Nephrol. 2000;11:9-17 pubmed
    ..Substrate-dependent currents provide a tool to elucidate the structure/function relationship of the renal organic anion transporter...
  53. Magri P, Auletta M, Andreucci M, Somma G, Musone D, Fiorillo M, et al. Sodium retention in preascitic stage of cirrhosis. Semin Nephrol. 2001;21:317-22 pubmed
    ..Our findings also show in this phase of the disease a preserved adaptation of RProx and RAS, thus suggesting that the observed tubular Na+ reabsorption derangement is probably related to abnormal ANP behavior...
  54. Woods L, Weeks D, Rasch R. Hypertension after neonatal uninephrectomy in rats precedes glomerular damage. Hypertension. 2001;38:337-42 pubmed
    ..Hypertension is present earlier in life than signs of glomerular disease, which suggests that hypertension is a major contributor to rather than primarily resulting from onset of renal disease...
  55. El Kadi S, McLeod K, Elam N, Kitts S, Taylor C, Harmon D, et al. Nutrient net absorption across the portal-drained viscera of forage-fed beef steers: Quantitative assessment and application to a nutritional prediction model. J Anim Sci. 2008;86:2277-87 pubmed publisher
  56. Bakhiya N, Arlt V, Bahn A, Burckhardt G, Phillips D, Glatt H. Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy. Toxicology. 2009;264:74-9 pubmed publisher
    ..Our study indicates that OATs can mediate the uptake of AA into proximal tubule cells and thereby participate in kidney cell damage by this toxin...
  57. Ullrich K, Rumrich G, Kloss S. Contraluminal para-aminohippurate (PAH) transport in the proximal tubule of the rat kidney. IV. Specificity: mono- and polysubstituted benzene analogs. Pflugers Arch. 1988;413:134-46 pubmed
    ..The sulfate transporter interacts with molecules which have neighbouring electronegative charge accumulation...
  58. Korsatko W, Sadjak A, Gall P, Supanz S. [Development of combined inulin/p-aminohippuric acid (PAH) slow release implantation tablets for clearance determination in awake rats]. Pharmazie. 1987;42:324-7 pubmed
    ..The advantage of the method is that it can be used for renal clearance tests in small conscious animals, able to move freely within their cages without serious handling stress...
  59. Kuhn U, Lupp A, Kostka E, Kuhl A, Balogh A, Stein G, et al. Is there a beneficial effect of the calcium channel blocker diltiazem on cyclosporine A nephrotoxicity in rats?. Exp Toxicol Pathol. 1998;50:484-90 pubmed
    ..In general no significant differences were to be observed concerning lipid peroxidation and stimulated H2O2 formation. Altogether evident protective effects of diltiazem on CsA nephrotoxicity in rats could not be proven...
  60. Fisher N, Price D, Litchfield W, Williams G, Hollenberg N. Renal response to captopril reflects state of local renin system in healthy humans. Kidney Int. 1999;56:635-41 pubmed
    ..In this study we tested the hypothesis that variation in the renal vasodilator response to ACE inhibition in healthy humans reflected the variation in angiotensin-mediated renal vasoconstriction provoked by a low-salt diet...
  61. Le Floc h N, Mézière N, Seve B. Whole blood and plasma amino acid transfers across the portal drained viscera and liver of the pig. Reprod Nutr Dev. 1999;39:433-42 pubmed
    ..These data show that the contribution of plasma and whole blood to amino acid transport can be different between amino acids and between individual tissues...
  62. Mayer P, Vaes W, Hermens J. Absorption of hydrophobic compounds into the poly(dimethylsiloxane) coating of solid-phase microextraction fibers: high partition coefficients and fluorescence microscopy images. Anal Chem. 2000;72:459-64 pubmed
  63. Tanaka K, Zhou F, Kuze K, You G. Cysteine residues in the organic anion transporter mOAT1. Biochem J. 2004;380:283-7 pubmed
  64. Bleasby K, Hall L, Perry J, Mohrenweiser H, Pritchard J. Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). J Pharmacol Exp Ther. 2005;314:923-31 pubmed
  65. Uchida Y, Inazu M, Takeda H, Yamada T, Tajima H, Matsumiya T. Expression and functional characterization of choline transporter in human keratinocytes. J Pharmacol Sci. 2009;109:102-9 pubmed
    ..The present biochemical and pharmacological data suggest that CTL1a is functionally expressed in human keratinocytes and is responsible for the uptake of choline and organic cations in these cells...
  66. Schwartz L, Gewertz B, Bissell M. Chemical assay of p-aminohippuric acid simplified by use of dimethylaminocinnamaldehyde in ethanol. Clin Chem. 1988;34:165 pubmed
    ..This results in deeper and more stable color development. We have used this method successfully to determine effective renal plasma flow in a clinical study of this variable in pregnant women...
  67. Nagai J, Takano M, Hirozane K, Yasuhara M, Inui K. Specificity of p-aminohippurate transport system in the OK kidney epithelial cell line. J Pharmacol Exp Ther. 1995;274:1161-6 pubmed
    ..These findings suggest that the PAH transport system in OK cells has a substrate specificity similar to that in rat renal proximal tubules, which is involved in the active secretion of various organic anions including drugs...
  68. Radin M, Swayne D, Gigliotti A, Hoepf T. Renal function and organic anion and cation transport during dehydration and/or food restriction in chickens. J Comp Physiol B. 1996;166:138-43 pubmed
    ..Enhanced transport of organic anions in the presence of decreased glomerular filtration rate and effective renal plasma flow during dehydration may promote precipitation of urates and nephrosis in chickens...
  69. Schwerdt G, Gekle M, Freudinger R, Mildenberger S, Silbernagl S. Apical-to-basolateral transepithelial transport of Ochratoxin A by two subtypes of Madin-Darby canine kidney cells. Biochim Biophys Acta. 1997;1324:191-9 pubmed
    ..Thus, reabsorption of OTA in the collecting duct contributes to the observed long half life of OTA in the mammalian body...
  70. Willis L, Evan A, Connors B, Blomgren P, Fineberg N, Lingeman J. Relationship between kidney size, renal injury, and renal impairment induced by shock wave lithotripsy. J Am Soc Nephrol. 1999;10:1753-62 pubmed
    ..The injury induced by SWL affected a larger fraction of small kidneys than large ones, and the renal vasoconstriction induced by SWL was greatest in small kidneys...
  71. Leier I, Hummel Eisenbeiss J, Cui Y, Keppler D. ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2. Kidney Int. 2000;57:1636-42 pubmed
    ..This ATP-dependent export pump for anionic conjugates and additional amphiphilic anions was cloned recently and localized to the apical membrane of proximal tubules in human and rat kidney...
  72. Kohda Y, Gemba M. Modulation by cyclic AMP and phorbol myristate acetate of cephaloridine-induced injury in rat renal cortical slices. Jpn J Pharmacol. 2001;85:54-9 pubmed
    ..This enhancement by PMA of CER-induced injury was blocked by H-7, a PKC inhibitor. These results indicated that intracellular signaling pathways of cAMP and PKC modulate free radical-mediated nephrotoxicity induced by CER...
  73. Feng B, Shu Y, Giacomini K. Role of aromatic transmembrane residues of the organic anion transporter, rOAT3, in substrate recognition. Biochemistry. 2002;41:8941-7 pubmed
    ..Aromatic residues in this pocket may interact directly with substrates of rOAT3 through hydrogen bonds and pi-pi interactions...
  74. Schnabolk G, Youngblood G, Sweet D. Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20). Am J Physiol Renal Physiol. 2006;291:F314-21 pubmed
    ..These data demonstrate for the first time that the novel murine gene Oat6 (Slc22a20) encodes a functional organic anion transporter and mOat6 is indeed the newest member of the OAT gene family...
  75. Rush G, Heim R, Ponsler G, Engelhardt J. Cephaloridine-induced renal pathological and biochemical changes in female rabbits and isolated proximal tubules in suspension. Toxicol Pathol. 1992;20:155-68 pubmed
    ..These data demonstrate that isolated proximal tubules in vitro are a reasonable model for Cld nephrotoxicity in vivo. Cld-induced mitochondrial alterations leading to ATP depletion and cell injury were not observed in this study...
  76. Jakobson A. Transport of p-aminohippuric acid (3H-PAH), inulin and dextran out of the cranial cavity: a methodological study using intraventricular injection and sample combustion. Pharmacol Toxicol. 1987;61:228-35 pubmed
  77. Cloutier M. p-aminohippurate transport in the airways: role of Na+ and HCO3-. Am J Physiol. 1989;257:C1108-12 pubmed
    ..We conclude that PAH transport in canine tracheal epithelium occurs by a HCO3(-)-PAH exchange process located on the luminal membrane. PAH transport is not Na+ dependent but is inhibited by both DIDS and SITS...
  78. Izuno H, Kobayashi Y, Sanada Y, Nihei D, Suzuki M, Kohyama N, et al. Rat organic solute carrier protein 1 (rOscp1) mediated the transport of organic solutes in Xenopus laevis oocytes: isolation and pharmacological characterization of rOscp1. Life Sci. 2007;81:1183-92 pubmed
    ..Thus, the present results indicate that a newly isolated cDNA clone, rOscp1, is a polyspecific organic solute carrier protein with some differences in substrate specificity compared with human and mouse OSCP1...
  79. Choi M, Kim H, Han Y, Song I, Shim C. Involvement of Mrp2/MRP2 in the species different excretion route of benzylpenicillin between rat and human. Xenobiotica. 2009;39:171-81 pubmed publisher
  80. Pruijm M, Wuerzner G, Maillard M, Bovet P, Renaud C, Bochud M, et al. Glomerular hyperfiltration and increased proximal sodium reabsorption in subjects with type 2 diabetes or impaired fasting glucose in a population of the African region. Nephrol Dial Transplant. 2010;25:2225-31 pubmed publisher
    ..These findings provide further insight on the elevated incidence of nephropathy reported among African diabetic individuals...
  81. Sadjak A, Supanz S, Korsatko W, Erhart U, Muhry F. The suitability of a combined inulin/PAH retard tablet for measuring renal functions in the conscious rat. Agents Actions. 1988;24:210-4 pubmed
    ..o. The feasibility of the technique was checked by monitoring the behaviour of renal function after administration of a permanent adrenaline application, which we used as a well defined noxa...
  82. Lin J, Lin T. Renal handling of drugs in renal failure. I: Differential effects of uranyl nitrate- and glycerol-induced acute renal failure on renal excretion of TEAB and PAH in rats. J Pharmacol Exp Ther. 1988;246:896-901 pubmed
    ..This discrepancy may be due to the selective competitive inhibition of PAH secretion by the accumulation of naturally occurring organic acids.(ABSTRACT TRUNCATED AT 250 WORDS)..
  83. Kapiotis S, Jilma B, Szalay T, Dirnberger E, Wagner O, Eichler H, et al. Evidence against an effect of endothelin-1 on blood coagulation, fibrinolysis, and endothelial cell integrity in healthy men. Arterioscler Thromb Vasc Biol. 1997;17:2861-7 pubmed
    ..In contrast to previous reports from preclinical experiments, ET-1 does not appear to affect coagulation or fibrinolysis, nor does this peptide induce relevant endothelial cell perturbations in humans...
  84. Zalups R. Basolateral uptake of inorganic mercury in the kidney. Toxicol Appl Pharmacol. 1998;151:192-9 pubmed
    ..On the basis of the present findings, one is led to believe that mercuric conjugates of GSH and cysteine are taken up at the basolateral membrane following exposure to inorganic forms of mercury...
  85. Groves C, Morales M. Chlorotrifluoroethylcysteine interaction with rabbit proximal tubule cell basolateral membrane organic anion transport and apical membrane amino acid transport. J Pharmacol Exp Ther. 1999;291:555-61 pubmed
  86. Aas E, Baussant T, Balk L, Liewenborg B, Andersen O. PAH metabolites in bile, cytochrome P4501A and DNA adducts as environmental risk parameters for chronic oil exposure: a laboratory experiment with Atlantic cod. Aquat Toxicol. 2000;51:241-58 pubmed
    ..These dose-response data may serve as useful contributions when assessing environmental risk with regard to marine oil pollution...
  87. Guidi E, Minetti E, Cozzi M. Acute and long-term effects of ACE inhibition on renal haemodynamics in glomerular and interstitial nephropathies. J Renin Angiotensin Aldosterone Syst. 2002;3:40-5 pubmed
    ..This study investigates whether the acute and chronic effects of ACE inhibition on renal and glomerular haemodynamics are similar in glomerular and interstitial nephropathies...
  88. Iwakiri T, Okumura M, Hidaka M, Kumagai Y, Ichihara E, Kawano Y, et al. Inhibition of carrier-mediated uptake of epirubicin reduces cytotoxicity in primary culture of rat hepatocytes. J Appl Toxicol. 2008;28:329-36 pubmed
  89. Li M, Chung S, Hong S, Goldinger J. Effects of methylguanidine on sodium and organic ion transport. Nephron. 1992;60:349-53 pubmed
    ..These results are not consistent with the hypothesis that MG is a potential uremic toxin that causes the natriuresis and other toxic effects. However, long-term toxic effects of MG on the kidney were not assessed in the present study...
  90. Shimada H, Moewes B, Burckhardt G. Indirect coupling to Na+ of p-aminohippuric acid uptake into rat renal basolateral membrane vesicles. Am J Physiol. 1987;253:F795-801 pubmed
    ..We propose that dicarboxylates are cotransported with Na+ into the cell and subsequently exchange for extracellular PAH at the basolateral membrane. PAH uptake is thereby indirectly coupled to Na+ via the Na+/dicarboxylate cotransporter...
  91. Fleck C, Pertsch J. Epidermal growth factor (EGF) increases the renal amino acid transport capacity in amino acid loaded rats. Amino Acids. 1998;15:307-20 pubmed
    ..775 +/- 32 mg/100 g b.wt.). EGF can improve the renal tubular transport capacity, but, compared to well-known stimulators of renal transport like dexamethasone or triiodothyronine, its effect is only of a moderate degree...
  92. Fleck C, Pertsch J. Influence of epidermal growth factor (EGF) on renal transport of PAH and amino acids in amino acid loaded rats. Exp Toxicol Pathol. 1999;51:315-20 pubmed
    ..wt.). A simultaneous PAH load reduced amino acid reabsorption as a sign of overloading of renal tubular transport capacity, but in EGF pretreated animals the amino acid excretion was only slightly increased under these conditions...