deet

Summary

Summary: A compound used as a topical insect repellent that may cause irritation to eyes and mucous membranes, but not to the skin.

Top Publications

  1. Thavara U, Tawatsin A, Chompoosri J, Suwonkerd W, Chansang U, Asavadachanukorn P. Laboratory and field evaluations of the insect repellent 3535 (ethyl butylacetylaminopropionate) and deet against mosquito vectors in Thailand. J Am Mosq Control Assoc. 2001;17:190-5 pubmed
    The insect repellents 3535 (ethyl butylacetylaminopropionate or IR3535) and deet (N,N-diethyl-3-methylbenzamide) were prepared as 20% solutions in absolute ethanol and evaluated for repellency against many mosquito species in Thailand ..
  2. Debboun M, Wagman J. In vitro repellency of N,N-diethyl-3-methylbenzamide and N,N-diethylphenylacetamide analogs against Aedes aegypti and Anopheles stephensi (Diptera: Culicidae). J Med Entomol. 2004;41:430-4 pubmed
    Seventeen analogs of the repellent compounds N,N-diethyl-3-methylbenzamide (DEET) and N,N-diethylphenylacetamide (DEPA) were evaluated in vitro for repellency against laboratory-reared Aedes aegypti (L...
  3. Bohbot J, Dickens J. Odorant receptor modulation: ternary paradigm for mode of action of insect repellents. Neuropharmacology. 2012;62:2086-95 pubmed publisher
    ..Here, we study the effects of the repellents DEET and IR3535, and a novel OR co-receptor (Orco) agonist on odorant-evoked currents in Xenopus oocytes expressing two ..
  4. Xue R, Barnard D, Ali A. Laboratory and field evaluation of insect repellents as larvicides against the mosquitoes Aedes albopictus and Anopheles albimanus. Med Vet Entomol. 2001;15:374-80 pubmed
    Acute toxicity and persistence of three insect repellents, deet and two piperidines (AI3-35765 and AI3-37220), were evaluated against mosquito larvae of Aedes albopictus (Skuse) and Anopheles albimanus Wiedemann (Diptera: Culicidae) in ..
  5. Abou Donia M, Dechkovskaia A, Goldstein L, Abdel Rahman A, Bullman S, Khan W. Co-exposure to pyridostigmine bromide, DEET, and/or permethrin causes sensorimotor deficit and alterations in brain acetylcholinesterase activity. Pharmacol Biochem Behav. 2004;77:253-62 pubmed
    ..in the Persian Gulf War (PGW) were exposed to a combination of chemicals, including pyridostigmine bromide (PB), DEET, and permethrin...
  6. Xue R, Barnard D, Ali A. Laboratory and field evaluation of insect repellents as oviposition deterrents against the mosquito Aedes albopictus. Med Vet Entomol. 2001;15:126-31 pubmed
    ..insect repellents, AI3-35765, AI3-37220 (piperidine compounds), and the standard N,N-diethyl-3-methylbenzamide (deet) to the mosquito Aedes albopictus Skuse (Diptera: Culicidae). Against laboratory-reared Ae...
  7. Pennetier C, Corbel V, Hougard J. Combination of a non-pyrethroid insecticide and a repellent: a new approach for controlling knockdown-resistant mosquitoes. Am J Trop Med Hyg. 2005;72:739-44 pubmed
    ..In that context, the efficacy of a mixture of a repellent (N,N-diethyl toluamide [DEET]) and a non-pyrethroid insecticide (propoxur) was investigated under laboratory conditions against both pyrethroid-..
  8. Park B, Choi W, Kim J, Kim K, Lee S. Monoterpenes from thyme (Thymus vulgaris) as potential mosquito repellents. J Am Mosq Control Assoc. 2005;21:80-3 pubmed
    ..and carvacrol showed significantly greater repellency than a commercial formulation, N,N-diethyl-m-methylbenzamide (deet), whereas thymol showed similar repellency to that of deet...
  9. Stanczyk N, Brookfield J, Ignell R, Logan J, Field L. Behavioral insensitivity to DEET in Aedes aegypti is a genetically determined trait residing in changes in sensillum function. Proc Natl Acad Sci U S A. 2010;107:8575-80 pubmed publisher
    N,N-Diethyl-m-toluamide (DEET) is one of the most effective and commonly used mosquito repellents. However, during laboratory trials a small proportion of mosquitoes are still attracted by human odors despite the presence of DEET...

More Information

Publications79

  1. Tawatsin A, Thavara U, Chansang U, Chavalittumrong P, Boonruad T, Wongsinkongman P, et al. Field evaluation of deet, Repel Care, and three plant based essential oil repellents against mosquitoes, black flies (Diptera: Simuliidae) and land leeches (Arhynchobdellida: Haemadipsidae) in Thailand. J Am Mosq Control Assoc. 2006;22:306-13 pubmed
    Diethyl methyl benzamide, or deet, a commercial plant-based repellent (Repel Care), and essential ils from 3 species of plants (finger root rhizomes, guava leaves, and turmeric rhizomes), steam distillated and formulated as insect ..
  2. Kramer M, Feldlaufer M, Chauhan K. Mosquito biting behavior: statistical power and sources of variation in toxicity and repellent bioassays. J Med Entomol. 2010;47:199-204 pubmed
    ..females exposed to either alphacypermethrin or DEET were compared with the responses of mosquitoes exposed to untreated controls for toxicity and biting (..
  3. Miot H, Batistella R, Batista K, Volpato D, Augusto L, Madeira N, et al. Comparative study of the topical effectiveness of the Andiroba oil (Carapa guianensis) and DEET 50% as repellent for Aedes sp. Rev Inst Med Trop Sao Paulo. 2004;46:253-6 pubmed
    b>DEET (N,N-diethyl-3-methylbenzamide) is nowadays the most effective mosquito repellent available, however, its use can present some topical and systemic side effects...
  4. Osimitz T, Murphy J, Fell L, Page B. Adverse events associated with the use of insect repellents containing N,N-diethyl-m-toluamide (DEET). Regul Toxicol Pharmacol. 2010;56:93-9 pubmed publisher
    b>DEET is the major component of most topically applied insect repellents used in the US...
  5. Pennetier C, Costantini C, Corbel V, Licciardi S, Dabire R, Lapied B, et al. Synergy between repellents and organophosphates on bed nets: efficacy and behavioural response of natural free-flying An. gambiae mosquitoes. PLoS ONE. 2009;4:e7896 pubmed publisher
    ..trials run against free-flying Anopheles gambiae populations comparing the effects of two insect repellents (either DEET or KBR 3023, also known as icaridin) and an organophosphate insecticide at low-doses (pirimiphos-methyl, PM) used ..
  6. Pennetier C, Costantini C, Corbel V, Licciardi S, Dabire R, Lapied B, et al. Mixture for controlling insecticide-resistant malaria vectors. Emerg Infect Dis. 2008;14:1707-14 pubmed publisher
    ..Mixing repellents and organophosphates on bed nets could be used to control insecticide-resistant malaria vectors if residual activity of the mixture is extended and safety is verified. ..
  7. Sfara V, Mougabure Cueto G, Zerba E, Alzogaray R. Adaptation of the repellency response to DEET in Rhodnius prolixus. J Insect Physiol. 2011;57:1431-6 pubmed publisher
    For many years it has been accepted that DEET interferes with the detection of odours from the host instead of having a repellent effect...
  8. Badolo A, Ilboudo Sanogo E, Ouédraogo A, Costantini C. Evaluation of the sensitivity of Aedes aegypti and Anopheles gambiae complex mosquitoes to two insect repellents: DEET and KBR 3023. Trop Med Int Health. 2004;9:330-4 pubmed
    ..vectors of the Anopheles gambiae complex, in comparison with the standard repellent N,N-diethyl-3-methyl-benzamide (DEET)...
  9. Licciardi S, Herve J, Darriet F, Hougard J, Corbel V. Lethal and behavioural effects of three synthetic repellents (DEET, IR3535 and KBR 3023) on Aedes aegypti mosquitoes in laboratory assays. Med Vet Entomol. 2006;20:288-93 pubmed
    The knock-down, mortality and 'irritancy' effects of three synthetic repellents (DEET, IR3535 and KBR 3023) on Aedes aegypti (L) (Diptera: Culicidae) were evaluated in the laboratory in the absence of animal bait...
  10. Ditzen M, Pellegrino M, Vosshall L. Insect odorant receptors are molecular targets of the insect repellent DEET. Science. 2008;319:1838-42 pubmed publisher
    b>DEET (N,N-diethyl-meta-toluamide) is the world's most widely used topical insect repellent, with broad effectiveness against most insects. Its mechanism of action and molecular target remain unknown...
  11. Pickett J, Birkett M, Logan J. DEET repels ORNery mosquitoes. Proc Natl Acad Sci U S A. 2008;105:13195-6 pubmed publisher
  12. McGready R, Hamilton K, Simpson J, Cho T, Luxemburger C, Edwards R, et al. Safety of the insect repellent N,N-diethyl-M-toluamide (DEET) in pregnancy. Am J Trop Med Hyg. 2001;65:285-9 pubmed
    The safety of daily application of N, N-diethyl-m-toluamide (DEET) (1...
  13. Costantini C, Badolo A, Ilboudo Sanogo E. Field evaluation of the efficacy and persistence of insect repellents DEET, IR3535, and KBR 3023 against Anopheles gambiae complex and other Afrotropical vector mosquitoes. Trans R Soc Trop Med Hyg. 2004;98:644-52 pubmed
    ..vectors of disease to compare their relative efficacy and persistence profiles to those of the 'gold standard' DEET. Collection of >49000 mosquitoes (approximately 95% belonging to the Anopheles gambiae complex) showed that ..
  14. Klun J, Khrimian A, Rowton E, Kramer M, Debboun M. Biting deterrent activity of a deet analog, two DEPA analogs, and SS220 applied topically to human volunteers compared with deet against three species of blood-feeding flies. J Med Entomol. 2006;43:1248-51 pubmed
    An earlier in vitro screening of N,N-diethyl-3-methylbenzamide (Deet) and N,N-diethylphenylacetamide (DEPA) analogs showed that two DEPA analogs, N,N-diethyl(3-bromophenyl) acetamide and N,N-diethyl[(alpha,alpha,alpha-trifluoro-m-tolyl)]..
  15. Bernier U, Furman K, Kline D, Allan S, Barnard D. Comparison of contact and spatial repellency of catnip oil and N,N-diethyl-3-methylbenzamide (deet) against mosquitoes. J Med Entomol. 2005;42:306-11 pubmed
    Nepetalactone, the primary component of catnip oil, was compared with the repellent N,N-diethyl-3-methylbenzamide (deet) for its ability to affect the host-seeking ability of Aedes aegypti (L.)...
  16. Wille T, Thiermann H, Worek F. In vitro kinetic interactions of DEET, pyridostigmine and organophosphorus pesticides with human cholinesterases. Chem Biol Interact. 2011;190:79-83 pubmed publisher
    The simultaneous use of the repellent DEET, pyridostigmine, and organophosphorus pesticides has been assumed as a potential cause for the Gulf War Illness and combinations have been tested in different animal models...
  17. Faulde M, Albiez G, Nehring O. Insecticidal, acaricidal and repellent effects of DEET- and IR3535-impregnated bed nets using a novel long-lasting polymer-coating technique. Parasitol Res. 2010;106:957-65 pubmed publisher
    ..repellent-treated net (LLRTN) has been designed by binding the skin repellents N,N-diethyl-m-toluamide (DEET), or IR3535, onto the fibres of bed net fabric using a new polymer-coating technique...
  18. Costanzo S, Watkinson A, Murby E, Kolpin D, Sandstrom M. Is there a risk associated with the insect repellent DEET (N,N-diethyl-m-toluamide) commonly found in aquatic environments?. Sci Total Environ. 2007;384:214-20 pubmed
    b>DEET (N,N-diethyl-m-toluamide) is the active ingredient of most commercial insect repellents...
  19. Briassoulis G, Narlioglou M, Hatzis T. Toxic encephalopathy associated with use of DEET insect repellents: a case analysis of its toxicity in children. Hum Exp Toxicol. 2001;20:8-14 pubmed
    ..6%) N,N-diethyl-m-toluamide (DEET). A review of the literature revealed 17 reports of DEET-induced encephalopathy in children...
  20. Reeder N, Ganz P, Carlson J, Saunders C. Isolation of a deet-insensitive mutant of Drosophila melanogaster (Diptera: Drosophilidae). J Econ Entomol. 2001;94:1584-8 pubmed
    Despite the widespread use of N,N,-diethyl-3-methylbenzamide (deet) in insect repellent products, nothing is known about the molecular basis for the repellency of deet, we initiated a molecular genetics program to elucidate the molecular ..
  21. Sudakin D, Trevathan W. DEET: a review and update of safety and risk in the general population. J Toxicol Clin Toxicol. 2003;41:831-9 pubmed
    ..has resulted in increased public awareness and utilization of insect repellents containing N,N-diethyl-m-toluamide (DEET) in the prevention of mosquito-borne disease...
  22. Antwi F, Shama L, Peterson R. Risk assessments for the insect repellents DEET and picaridin. Regul Toxicol Pharmacol. 2008;51:31-6 pubmed publisher
    For the use of topical insect repellents, DEET and picaridin, human health risk assessments were conducted for various population subgroups. Acute, subchronic, and chronic dermal exposures were examined...
  23. Carroll S, Loye J. PMD, a registered botanical mosquito repellent with deet-like efficacy. J Am Mosq Control Assoc. 2006;22:507-14 pubmed
    ..citriodora). In April 2005, the U.S. Centers for Disease Control and Prevention (CDC) endorsed two non-deet mosquito repellents, including PMD...
  24. Chen Hussey V, Carneiro I, Keomanila H, Gray R, Bannavong S, Phanalasy S, et al. Can topical insect repellents reduce malaria? A cluster-randomised controlled trial of the insect repellent N,N-diethyl-m-toluamide (DEET) in Lao PDR. PLoS ONE. 2013;8:e70664 pubmed publisher
    ..Topical insect repellents may be able to protect users from outdoor biting, thereby providing additional protection above the current best practice of LLINs...
  25. Corbel V, Stankiewicz M, Pennetier C, Fournier D, Stojan J, Girard E, et al. Evidence for inhibition of cholinesterases in insect and mammalian nervous systems by the insect repellent deet. BMC Biol. 2009;7:47 pubmed publisher
    N,N-Diethyl-3-methylbenzamide (deet) remains the gold standard for insect repellents. About 200 million people use it every year and over 8 billion doses have been applied over the past 50 years...
  26. Hoffmann E, Miller J. Reduction of mosquito (Diptera: Culicidae) attacks on a human subject by combination of wind and vapor-phase DEET repellent. J Med Entomol. 2002;39:935-8 pubmed
    In a Central Michigan wetland setting, air drawn through a DEET-impregnated screen using an electric fan and projected toward a human subject significantly reduced mosquito orientation by 74%, landing by 75%, and probing by 70%, relative ..
  27. Weigel S, Kuhlmann J, Hühnerfuss H. Drugs and personal care products as ubiquitous pollutants: occurrence and distribution of clofibric acid, caffeine and DEET in the North Sea. Sci Total Environ. 2002;295:131-41 pubmed
    ..areas for clofibric acid, diclofenac, ibuprofen, ketoprofen, propyphenazone, caffeine and N,N-diethyl-3-toluamide (DEET)...
  28. Weeks J, Guiney P, Nikiforov A. Assessment of the environmental fate and ecotoxicity of N,N-diethyl-m-toluamide (DEET). Integr Environ Assess Manag. 2012;8:120-34 pubmed publisher
    N,N-diethyl-m-toluamide (DEET) is a key active ingredient in many insect repellents available commercially throughout the world...
  29. Staub D, Debrunner M, Amsler L, Steffen R. Effectiveness of a repellent containing DEET and EBAAP for preventing tick bites. Wilderness Environ Med. 2002;13:12-20 pubmed
    ..repellent spray containing both N,N-diethyl-3-methylbenzamide, previously known as N,N-diethyl-m-toluamide (DEET), and ethyl-butylacetylaminopropionate (EBAAP) against tick bites in a population at risk in Switzerland under real-..
  30. Klun J, Kramer M, Debboun M. Four simple stimuli that induce host-seeking and blood-feeding behaviors in two mosquito species, with a clue to DEET's mode of action. J Vector Ecol. 2013;38:143-53 pubmed publisher
    ..When mosquitoes were exposed to the four stimuli along with N,N-diethyl-3-methylbenzamide (DEET), feeding behavior was greatly suppressed...
  31. Chen T, Burczynski F, Miller D, Gu X. Percutaneous permeation comparison of repellents picaridin and DEET in concurrent use with sunscreen oxybenzone from commercially available preparations. Pharmazie. 2010;65:835-9 pubmed
    Concurrent application of insect repellent picaridin or DEET with sunscreens has become prevalent due to concerns on West Nile virus and skin cancer...
  32. Manikkam M, Tracey R, Guerrero Bosagna C, Skinner M. Pesticide and insect repellent mixture (permethrin and DEET) induces epigenetic transgenerational inheritance of disease and sperm epimutations. Reprod Toxicol. 2012;34:708-19 pubmed publisher
    ..determine if a "pesticide mixture" (pesticide permethrin and insect repellent N,N-diethyl-meta-toluamide, DEET) promotes epigenetic transgenerational inheritance of disease and associated DNA methylation epimutations in sperm...
  33. Abu Qare A, Suliman H, Abou Donia M. Induction of urinary excretion of 3-nitrotyrosine, a marker of oxidative stress, following administration of pyridostigmine bromide, DEET (N,N-diethyl-m-toluamide) and permethrin, alone and in combination in rats. Toxicol Lett. 2001;121:127-34 pubmed
    ..3-dimethylaminocarbonyloxy-N-methylpyridinum bromide), a single dermal dose of 400 mg/kg N,N-diethyl-m-toluamide (DEET) and a single dermal dose of 1.3 mg/kg permethrin, alone and in combination...
  34. Pennetier C, Corbel V, Boko P, Odjo A, N Guessan R, Lapied B, et al. Synergy between repellents and non-pyrethroid insecticides strongly extends the efficacy of treated nets against Anopheles gambiae. Malar J. 2007;6:38 pubmed
    ..Recently, mixing repellents (DEET) and a non-pyrethroid insecticide (propoxur) was shown to be as effective as deltamethrin, a standard pyrethroid, ..
  35. Durrheim D, Govere J. Malaria outbreak control in an African village by community application of 'deet' mosquito repellent to ankles and feet. Med Vet Entomol. 2002;16:112-5 pubmed
    ..Topical application of insect repellent, 15% deet (N,N-diethyl-3-methylbenzamide), to feet and ankles reduced the overall biting rate of An. arabiensis by 69%...
  36. Koren G, Matsui D, Bailey B. DEET-based insect repellents: safety implications for children and pregnant and lactating women. CMAJ. 2003;169:209-12 pubmed
    ..Repellents containing DEET (N,N-diethyl-m-toluamide, also known as N,N-diethyl-3-methylbenzamide) are the most effective and most widely used...
  37. Waka M, Hopkins R, Glinwood R, Curtis C. The effect of repellents Ocimum forskolei and deet on the response of Anopheles stephensi to host odours. Med Vet Entomol. 2006;20:373-6 pubmed
    ..from human and goat) and to human odour in combination with a repellent plant, Ocimum forskolei (Labiatae), or deet (N, N, diethyl-toluamide) (20%) was tested in a dual-port olfactometer. An...
  38. Abou Donia M, Wilmarth K, Jensen K, Oehme F, Kurt T. Neurotoxicity resulting from coexposure to pyridostigmine bromide, deet, and permethrin: implications of Gulf War chemical exposures. J Toxicol Environ Health. 1996;48:35-56 pubmed
    ..agent pyridostigmine bromide (PB; 3-dimethylaminocarbonyloxy-N-methylpyridinium bromide), the insect repellent DEET (N,N-diethyl-m-toluamide), and the insecticide permethrin (3-(2,2-dichloro-ethenyl)-2,2-..
  39. Abu Qare A, Abou Donia M. Simultaneous determination of malathion, permethrin, DEET (N,N-diethyl-m-toluamide), and their metabolites in rat plasma and urine using high performance liquid chromatography. J Pharm Biomed Anal. 2001;26:291-9 pubmed
    ..of its metabolites m-phenoxybenzyl alcohol and m-phenoxybenzoic acid, the insect repellent N,N-diethyl-m-toluamide (DEET), and its metabolites m-toluamide and m-toluic acid in rat plasma and urine...
  40. Kendrick D. Mosquito repellents and superwarfarin rodenticides--are they really toxic in children?. Curr Opin Pediatr. 2006;18:180-3 pubmed
    ..This review provides information on common mosquito repellents and rodenticides used in households and discusses their toxicity, in order to help pediatricians better advise their patients of their proper use...
  41. Fradin M, Day J. Comparative efficacy of insect repellents against mosquito bites. N Engl J Med. 2002;347:13-8 pubmed
    ..We sought to determine which products available in the United States provide reliable and prolonged complete protection from mosquito bites...
  42. Kitchen L, Lawrence K, Coleman R. The role of the United States military in the development of vector control products, including insect repellents, insecticides, and bed nets. J Vector Ecol. 2009;34:50-61 pubmed publisher
    ..of many of the most effective PPM and vector control products available today, including the topical repellent DEET and the repellent/insecticide permethrin, which is applied to clothing and bed nets...
  43. Rowland M, Downey G, Rab A, Freeman T, Mohammad N, Rehman H, et al. DEET mosquito repellent provides personal protection against malaria: a household randomized trial in an Afghan refugee camp in Pakistan. Trop Med Int Health. 2004;9:335-42 pubmed
    Synthetic repellents based on di-ethyl 3-methyl benzamide (DEET) are a popular method of obtaining protection from mosquitoes and yet clear evidence for a protective effect against malaria has hitherto never been convincingly demonstrated...
  44. Tikar S, Yadav R, Mendki M, Rao A, Sukumaran D, Parashar B. Oviposition deterrent activity of three mosquito repellents diethyl phenyl acetamide (DEPA), diethyl m toluamide (DEET), and diethyl benzamide (DEB) on Aedes aegypti, Aedes albopictus, and Culex quinquefasciatus. Parasitol Res. 2014;113:101-6 pubmed publisher
    ..mosquito repellents namely diethyl phenyl acetamide (DEPA), diethyl benzamide (DEB) along with diethyl toluamide (DEET) was studied in the laboratory against Aedes aegypti, A. albopictus, and Culex quinquefasciatus mosquitoes...
  45. Frances S, Cooper R, Popat S, Beebe N. Field evaluation of repellents containing deet and AI3-37220 against Anopheles koliensis in Papua New Guinea. J Am Mosq Control Assoc. 2001;17:42-4 pubmed
    ..AI3-37220) was compared with 2 formulations of diethylmethylbenzamide (deet) for its effectiveness in protecting 4 humans against the bites of Anopheles koliensis mosquitoes at a village in ..
  46. Rowland M, Freeman T, Downey G, Hadi A, Saeed M. DEET mosquito repellent sold through social marketing provides personal protection against malaria in an area of all-night mosquito biting and partial coverage of insecticide-treated nets: a case-control study of effectiveness. Trop Med Int Health. 2004;9:343-50 pubmed
    b>DEET (diethyl-3-methylbenzamide), the widely used mosquito repellent, has the potential to prevent malarial infection but hitherto there has been no study demonstrating this possibility during normal everyday use...
  47. Kasichayanula S, House J, Wang T, Gu X. Percutaneous characterization of the insect repellent DEET and the sunscreen oxybenzone from topical skin application. Toxicol Appl Pharmacol. 2007;223:187-94 pubmed
    The synergistic percutaneous enhancement between insect repellent DEET and sunscreen oxybenzone has been proven in our laboratory using a series of in vitro diffusion studies...
  48. Katz T, Miller J, Hebert A. Insect repellents: historical perspectives and new developments. J Am Acad Dermatol. 2008;58:865-71 pubmed publisher
    ..Active ingredients of currently available IRs include N,N-diethyl-3-methylbenzamide (DEET), botanicals, citronella, and, the newest agent, picaridin...
  49. Carroll J, Benante J, Klun J, White C, Debboun M, Pound J, et al. Twelve-hour duration testing of cream formulations of three repellents against Amblyomma americanum. Med Vet Entomol. 2008;22:144-51 pubmed publisher
    The repellent efficacies of the U.S. military repellent 33% N,N-diethyl-3-methylbenzamide (deet), 10% and 20% (1S, 2'S) 2-methylpiperidinyl-3-cyclohexene-1-carboxamide (SS220) and 10% and 20% 1-methyl-propyl-2-(hydroxyethyl)-1-..
  50. Frances S, Mackenzie D, Klun J, Debboun M. Laboratory and field evaluation of SS220 and deet against mosquitoes in Queensland, Australia. J Am Mosq Control Assoc. 2009;25:174-8 pubmed
    Laboratory and field efficacy trials comparing deet (N,N-diethyl-3-methylbenzamide) and SS220 [(IS, 2'S)-2-methylpiperindinyl-3-cyclohexen-1-carboxamide] against mosquitoes in Queensland, Australia, were conducted...
  51. Buka R. Sunscreens and insect repellents. Curr Opin Pediatr. 2004;16:378-84 pubmed
  52. Kline D, Bernier U, Posey K, Barnard D. Olfactometric evaluation of spatial repellents for Aedes aegypti. J Med Entomol. 2003;40:463-7 pubmed
    The spatial repellency responses of Aedes aegypti (L.) to deet, dehydrolinalool and linalool were evaluated using a dual port olfactometer...
  53. Pellegrino M, Steinbach N, Stensmyr M, Hansson B, Vosshall L. A natural polymorphism alters odour and DEET sensitivity in an insect odorant receptor. Nature. 2011;478:511-4 pubmed publisher
    ..Insect repellents containing DEET (N,N-diethyl-meta-toluamide) are highly effective, but the mechanism by which this chemical wards off biting ..
  54. Xue R, Ali A, Barnard D. Effects of forced egg-retention in Aedes albopictus on adult survival and reproduction following application of DEET as an oviposition deterrent. J Vector Ecol. 2005;30:45-8 pubmed
    The insect repellent DEET (0.1% concentration), used as a mosquito oviposition deterrent in the laboratory, influenced the retention and maintenance of mature eggs by caged gravid female Aedes albopictus Skuse...
  55. Syed Z, Leal W. Mosquitoes smell and avoid the insect repellent DEET. Proc Natl Acad Sci U S A. 2008;105:13598-603 pubmed publisher
    The insect repellent DEET is effective against a variety of medically important pests, but its mode of action still draws considerable debate...
  56. Moore S, Davies C, Hill N, Cameron M. Are mosquitoes diverted from repellent-using individuals to non-users? Results of a field study in Bolivia. Trop Med Int Health. 2007;12:532-9 pubmed
    ..Each of the six volunteer-pairs sat >20 m apart from other pairs. Volunteers were allocated di-ethyl toluamide (DEET) or mineral oil in ethanol control...
  57. Shelomi M, Matern L, Dinstell J, Harris D, Kimsey R. DEET (N,N-diethyl-meta-toluamide) induced delay of blowfly landing and oviposition rates on treated pig carrion (Sus scrofa L.). J Forensic Sci. 2012;57:1507-11 pubmed publisher
    The question of whether the insect repellent N,N-Diethyl-meta-toluamide (DEET) affected fly attraction, oviposition, and larval development was investigated; in part, to determine whether the common habit of wearing DEET as a repellent ..
  58. Qualls W, Day J, Xue R, Bowers D. Altered behavioral responses of Sindbis virus-infected Aedes aegypti (Diptera: Culicidae) to DEET and non-DEET based insect repellents. Acta Trop. 2012;122:284-90 pubmed publisher
    ..dissemination of Sindbis virus (SINV) were observed after exposure to repellents with the active ingredients (AI) DEET, picaridin, 2-undecanone (2-U), and oil of lemon eucalyptus. Dissemination of SINV significantly decreased (P<0...
  59. Abramson C, Giray T, Mixson T, Nolf S, Wells H, Kence A, et al. Proboscis conditioning experiments with honeybees, Apis mellifera caucasica, with butyric acid and DEET mixture as conditioned and unconditioned stimuli. J Insect Sci. 2010;10:122 pubmed publisher
    Three experiments are described investigating whether olfactory repellents DEET and butyric acid can support the classical conditioning of proboscis extension in the honeybee, Apis mellifera caucasica (Hymenoptera: Apidae)...
  60. Deparis X, Frere B, Lamizana M, N Guessan R, Leroux F, Lefevre P, et al. Efficacy of permethrin-treated uniforms in combination with DEET topical repellent for protection of French military troops in Côte d'Ivoire. J Med Entomol. 2004;41:914-21 pubmed
    ..permethrin preimpregnated battlefield uniforms (BFUs) and the application on the skin of a topical repellent (50% DEET)...
  61. Abou Donia M, Suliman H, Khan W, Abdel Rahman A. Testicular germ-cell apoptosis in stressed rats following combined exposure to pyridostigmine bromide, N,N-diethyl m-toluamide (DEET), and permethrin. J Toxicol Environ Health A. 2003;66:57-73 pubmed
    ..treatment against nerve agents during the Persian Gulf War; the insect repellent N,N-diethyl m-toluamide (DEET, 40 mg/kg/d in ethanol, dermal); and the insecticide permethrin (0...
  62. Lee Y, Kim S, Montell C. Avoiding DEET through insect gustatory receptors. Neuron. 2010;67:555-61 pubmed publisher
    b>DEET is the most widely used insect repellent worldwide. In Drosophila olfactory receptor neurons (ORNs), DEET is detected through a mechanism employing the olfactory receptor, OR83b...
  63. Moore S, Lenglet A, Hill N. Field evaluation of three plant-based insect repellents against malaria vectors in Vaca Diez Province, the Bolivian Amazon. J Am Mosq Control Assoc. 2002;18:107-10 pubmed
    ..based, 1 neem based, and 1 containing several repellent essential oils) were tested in comparison with 15% deet in human landing catches in Bolivia...
  64. Frances S, Waterson D, Beebe N, Cooper R. Field evaluation of repellent formulations containing deet and picaridin against mosquitoes in Northern Territory, Australia. J Med Entomol. 2004;41:414-7 pubmed
    ..of repellent formulations containing picaridin (1-methyl-propyl 2-(2-hydroxyethyl)-1-piperidinecarboxylate) or deet (N,N,-diethyl-3-methylbenzamide) against mosquitoes in Northern Territory, Australia, was evaluated...
  65. Klun J, Strickman D, Rowton E, Williams J, Kramer M, Roberts D, et al. Comparative resistance of Anopheles albimanus and Aedes aegypti to N,N-diethyl-3-methylbenzamide (Deet) and 2-methylpiperidinyl-3-cyclohexen-1-carboxamide (AI3-37220) in laboratory human-volunteer repellent assays. J Med Entomol. 2004;41:418-22 pubmed
    The insect repellents N,N-diethyl-3-methylbenzamide (Deet) and the racemate and 1S,2'S stereoisomer of 2-methylpiperidinyl-3-cyclohexene-1-carboxamide (AI3-37220) were tested against Anopheles albimanus Wiedemann and Aedes aegypti (L...
  66. Schofield S, Tepper M, Gadawski R. Laboratory and field evaluation of the impact of exercise on the performance of regular and polymer-based deet repellents. J Med Entomol. 2007;44:1026-31 pubmed
    ..Two products containing the active ingredient N,N-diethyl-3-methylbenzamide (deet) were tested; one product was a polymer-based cream (3M Ultrathon Insect Repellent) and the other product was an ..
  67. Krajick K. Medical entomology. Keeping the bugs at bay. Science. 2006;313:36-8 pubmed
  68. Quednow K, Püttmann W. Temporal concentration changes of DEET, TCEP, terbutryn, and nonylphenols in freshwater streams of Hesse, Germany: possible influence of mandatory regulations and voluntary environmental agreements. Environ Sci Pollut Res Int. 2009;16:630-40 pubmed publisher
    ..NP), 2-(t-butylamino)-4-(ethylamino)-6-(methylthio)-s-triazine (terbutryn), and N,N-diethyl-m-toluamide (DEET)) are subject to differing regulations...
  69. Das P, Cao Y, Rose R, Cherrington N, Hodgson E. Enzyme induction and cytotoxicity in human hepatocytes by chlorpyrifos and N,N-diethyl-m-toluamide (DEET). Drug Metabol Drug Interact. 2008;23:237-60 pubmed
    ..The present study was designed to examine chlorpyrifos and DEET mediated induction of CYP isoforms and also to characterize their potential cytotoxic effects on primary human ..
  70. Abdel Rahman A, Abou Donia S, El Masry E, Shetty A, ABOU DONIA M. Stress and combined exposure to low doses of pyridostigmine bromide, DEET, and permethrin produce neurochemical and neuropathological alterations in cerebral cortex, hippocampus, and cerebellum. J Toxicol Environ Health A. 2004;67:163-92 pubmed
    Exposure to a combination of stress and low doses of the chemicals pyridostigmine bromide (PB), DEET, and permethrin in adult rats, a model of Gulf War exposure, produces blood-brain barrier (BBB) disruption and neuronal cell death in the ..