amides

Summary

Summary: Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)

Top Publications

  1. Giannetti A, Zheng X, Skelton N, Wang W, Bravo B, Bair K, et al. Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). J Med Chem. 2014;57:770-92 pubmed publisher
    ..0051 ?M, A2780 cell culture IC50 = 0.000?49 ?M) which demonstrated encouraging in vivo efficacy in an HT-1080 mouse xenograft tumor model. ..
  2. Li J, Subramaniam K, Smith D, Qiao J, Li J, Qian Cutrone J, et al. AlMe(3)-promoted formation of amides from acids and amines. Org Lett. 2012;14:214-7 pubmed publisher
    ..amines can be directly coupled with acids through dimethylaluminum amide intermediates to form the corresponding amides. A wide range of amines and acids including less nucleophilic amines, bulky amines, unprotected secondary amino ..
  3. Parving H, Brenner B, McMurray J, de Zeeuw D, Haffner S, Solomon S, et al. Cardiorenal end points in a trial of aliskiren for type 2 diabetes. N Engl J Med. 2012;367:2204-13 pubmed publisher
    ..This study was undertaken to determine whether use of the direct renin inhibitor aliskiren would reduce cardiovascular and renal events in patients with type 2 diabetes and chronic kidney disease, cardiovascular disease, or both...
  4. Angeli F, Reboldi G, Mazzotta G, Poltronieri C, Verdecchia P. Safety and efficacy of aliskiren in the treatment of hypertension: a systematic overview. Expert Opin Drug Saf. 2012;11:659-70 pubmed publisher
    ..Aliskiren's inhibitory effect on angiotensin I generation, through renin blockade, is highly specific and long-lasting (24 hours). This feature differentiates aliskiren from traditional antihypertensive drugs...
  5. Vitorović Todorović M, Erić Nikolić A, Kolundžija B, Hamel E, Ristić S, Juranić I, et al. (E)-4-aryl-4-oxo-2-butenoic acid amides, chalcone-aroylacrylic acid chimeras: design, antiproliferative activity and inhibition of tubulin polymerization. Eur J Med Chem. 2013;62:40-50 pubmed publisher
    Antiproliferative activity of twenty-nine (E)-4-aryl-4-oxo-2-butenoic acid amides against three human tumor cell lines (HeLa, FemX, and K562) is reported...
  6. Carocci A, Catalano A, Bruno C, Lovece A, Roselli M, Cavalluzzi M, et al. N-(Phenoxyalkyl)amides as MT(1) and MT(2) ligands: antioxidant properties and inhibition of Ca(2+)/CaM-dependent kinase II. Bioorg Med Chem. 2013;21:847-51 pubmed publisher
    Recently a series of chiral N-(phenoxyalkyl)amides have been reported as potent MT(1) and MT(2) melatonergic ligands...
  7. Sung H, Ok S, Sohn J, Son Y, Kim J, Lee S, et al. Vasoconstriction potency induced by aminoamide local anesthetics correlates with lipid solubility. J Biomed Biotechnol. 2012;2012:170958 pubmed publisher
    ..001). The potency of the vasoconstriction in the endothelium-denuded aorta induced by local anesthetics is determined primarily by lipid solubility and, in part, by other physicochemical properties including potency and pKa...
  8. Villar Cheda B, Dominguez Meijide A, Joglar B, Rodriguez Perez A, Guerra M, Labandeira Garcia J. Involvement of microglial RhoA/Rho-kinase pathway activation in the dopaminergic neuron death. Role of angiotensin via angiotensin type 1 receptors. Neurobiol Dis. 2012;47:268-79 pubmed publisher
    ..ROCK inhibitors and AT1 receptor antagonists may provide new neuroprotective strategies against the progression of Parkinson's disease...
  9. Tang A, Campbell W, Nithipatikom K. ROCK1 feedback regulation of the upstream small GTPase RhoA. Cell Signal. 2012;24:1375-80 pubmed publisher

More Information

Publications62

  1. Wu J, Song B, Hu D, Yue M, Yang S. Design, synthesis and insecticidal activities of novel pyrazole amides containing hydrazone substructures. Pest Manag Sci. 2012;68:801-10 pubmed publisher
    ..In an effort to discover new molecules with good insecticidal activities, a series of pyrazole amide derivatives containing hydrazone substructures were synthesised and bioassayed...
  2. Morin M, Lu Y, Black D, Arndtsen B. Copper-catalyzed Petasis-type reaction: a general route to ?-substituted amides from imines, acid chlorides, and organoboron reagents. J Org Chem. 2012;77:2013-7 pubmed publisher
    A copper-catalyzed Petasis-type reaction of imines, acid chlorides, and organoboranes to form ?-substituted amides is described...
  3. Zheng X, Bair K, Bauer P, Baumeister T, Bowman K, Buckmelter A, et al. Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett. 2013;23:5488-97 pubmed publisher
    ..The crystal structures of compound 26 and the corresponding PRPP-derived ribose adduct in complex with NAMPT were also obtained. ..
  4. Zheng B, Jia T, Walsh P. Palladium-catalyzed direct intermolecular ?-arylation of amides with aryl chlorides. Org Lett. 2013;15:4190-3 pubmed publisher
    ..Chemoselectivities up to 10:1 in the mono- and diarylation of acetamides were achieved by careful selection of bases, solvents, and stoichiometry. Bis-arylated amides were prepared in up to 95% yield.
  5. Li S, Chen Y, Yang W, Tarng D, Lin C, Yang C, et al. Effect of add-on direct renin inhibitor aliskiren in patients with non-diabetes related chronic kidney disease. BMC Nephrol. 2012;13:89 pubmed publisher
    ..The aim of this study was to evaluate the potential renoprotective effect of add-on direct renin inhibitor in non-DM CKD patients...
  6. Rocha Pereira J, Jochmans D, Dallmeier K, Leyssen P, Nascimento M, Neyts J. Favipiravir (T-705) inhibits in vitro norovirus replication. Biochem Biophys Res Commun. 2012;424:777-80 pubmed publisher
    ..Time-of-drug addition studies reveal that T-705 exerts its activity at a time-point that coincides with onset of viral RNA synthesis, which is in line with the viral polymerase as the presumed target...
  7. Sakai Y, Otsuka T, Ohno D, Murasawa T, Sato N, Mizuno K. Efficacy of aliskiren in Japanese chronic kidney disease patients with hypertension. Ren Fail. 2012;34:442-7 pubmed publisher
    ..This study attempted to provide insight into this mechanism by examining the antihypertensive and renoprotective effects of aliskiren in hypertensive chronic kidney disease (CKD) patients...
  8. Shi Z, Li N, Shi Q, Tang H, Tang Y, Li W, et al. Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors. Bioorg Med Chem Lett. 2013;23:1206-11 pubmed publisher
    Four series of acid amides were synthesized, and through measurement using a fluorogenic substrate assay with human recombinant MMP-1, MMP-2 and MMP-9, compound 3f showed considerable inhibitory activities against MMP-2, MMP-9 and the ..
  9. Horvath U, Dobrzańska L, Strasser C, Bouwer Neé Potgieter W, Jooné G, van Rensburg C, et al. Amides of gold(I) diphosphines prepared from N-heterocyclic sources and their in vitro and in vivo screening for anticancer activity. J Inorg Biochem. 2012;111:80-90 pubmed publisher
  10. Gao Y, Kodadek T. Synthesis and screening of stereochemically diverse combinatorial libraries of peptide tertiary amides. Chem Biol. 2013;20:360-9 pubmed publisher
    ..A model screening experiment and analysis of the hits indicates that the rigidity afforded by the stereocenters is critical for high affinity binding...
  11. Lizakowski S, Tylicki L, Renke M, Rutkowski P, Heleniak Z, Sławińska Morawska M, et al. Aliskiren and perindopril reduce the levels of transforming growth factor-? in patients with non-diabetic kidney disease. Am J Hypertens. 2012;25:636-9 pubmed publisher
  12. Kuchálik J, Granath B, Ljunggren A, Magnuson A, Lundin A, Gupta A. Postoperative pain relief after total hip arthroplasty: a randomized, double-blind comparison between intrathecal morphine and local infiltration analgesia. Br J Anaesth. 2013;111:793-9 pubmed publisher
    ..Postoperative pain after total hip arthroplasty (THA) can delay mobilization. This was assessed after intrathecal morphine (ITM) compared with local infiltration analgesia (LIA) using a non-inferiority design...
  13. Mendenhall M, Russell A, Smee D, Hall J, Skirpstunas R, Furuta Y, et al. Effective oral favipiravir (T-705) therapy initiated after the onset of clinical disease in a model of arenavirus hemorrhagic Fever. PLoS Negl Trop Dis. 2011;5:e1342 pubmed publisher
    ..At present, ribavirin is the only antiviral drug indicated for use in treatment of these diseases, but because of its limited efficacy in advanced cases of disease and its toxicity, safer and more effective antivirals are needed...
  14. Marchais Oberwinkler S, Xu K, Wetzel M, Perspicace E, Negri M, Meyer A, et al. Structural optimization of 2,5-thiophene amides as highly potent and selective 17?-hydroxysteroid dehydrogenase type 2 inhibitors for the treatment of osteoporosis. J Med Chem. 2013;56:167-81 pubmed publisher
    ..SAR studies allowed a first characterization of the human 17?-HSD2 active site, which is predicted to be considerably larger than that of 17?-HSD1...
  15. Xiang Y, Dunetz J, Lovdahl M. Chiral separation of amides using supercritical fluid chromatography. J Chromatogr A. 2013;1293:150-8 pubmed publisher
    ..Comparatively, the IC and OD-H columns showed the best results for this group of amides, yielding baseline separations for eight of nine pairs...
  16. Newberry R, VanVeller B, Guzei I, Raines R. n??* interactions of amides and thioamides: implications for protein stability. J Am Chem Soc. 2013;135:7843-6 pubmed publisher
    Carbonyl-carbonyl interactions between adjacent backbone amides have been implicated in the conformational stability of proteins...
  17. Sarabia F, Vivar García C, García Castro M, García Ruiz C, Martín Gálvez F, Sánchez Ruiz A, et al. A highly stereoselective synthesis of glycidic amides based on a new class of chiral sulfonium salts: applications in asymmetric synthesis. Chemistry. 2012;18:15190-201 pubmed publisher
    ..of the sulfonium salts, reacted smoothly with a broad array of simple and chiral aldehydes to provide trans-epoxy amides in reasonable to very good yields and excellent stereoselectivities (>98%)...
  18. Okumura N, Koizumi N, Ueno M, Sakamoto Y, Takahashi H, Tsuchiya H, et al. ROCK inhibitor converts corneal endothelial cells into a phenotype capable of regenerating in vivo endothelial tissue. Am J Pathol. 2012;181:268-77 pubmed publisher
  19. Liu B, Thacker P, McKinnon J, Yu P. In-depth study of the protein molecular structures of different types of dried distillers grains with solubles and their relationship to digestive characteristics. J Sci Food Agric. 2013;93:1438-48 pubmed publisher
  20. Rivara S, Pala D, Lodola A, Mor M, Lucini V, Dugnani S, et al. MT1-selective melatonin receptor ligands: synthesis, pharmacological evaluation, and molecular dynamics investigation of N-{[(3-O-substituted)anilino]alkyl}amides. ChemMedChem. 2012;7:1954-64 pubmed publisher
    ..N-(Anilinoalkyl)amides are a versatile class of melatonin receptor ligands that include nonselective MT1/MT2 agonists and MT2-selective ..
  21. Montaser R, Paul V, Luesch H. Marine cyanobacterial fatty acid amides acting on cannabinoid receptors. Chembiochem. 2012;13:2676-81 pubmed publisher
    Striking cAMP: certain fatty acid amides from marine cyanobacteria can mimic the endocannabinoids...
  22. Kamer K, Choudhary A, Raines R. Intimate interactions with carbonyl groups: dipole-dipole or n??*?. J Org Chem. 2013;78:2099-103 pubmed publisher
    ..Moreover, we found that structures with a short X(-)···C?O contact display the signatures of an n??* interaction. We conclude that intimate interactions with carbonyl groups do not require a dipole...
  23. Lizakowski S, Tylicki L, Renke M, Rutkowski P, Heleniak Z, Sławińska Morawska M, et al. Effect of aliskiren on proteinuria in non-diabetic chronic kidney disease: a double-blind, crossover, randomised, controlled trial. Int Urol Nephrol. 2012;44:1763-70 pubmed
    ..To evaluate the proteinuria-lowering effect of a renin inhibitor (aliskiren), compared to placebo and to an angiotensin-converting enzyme inhibitor (perindopril), in patients with non-diabetic chronic kidney disease...
  24. Kundu D, Bhadra S, Mukherjee N, Sreedhar B, Ranu B. Heterogeneous Cu(II) -catalysed solvent-controlled selective N-arylation of cyclic amides and amines with bromo-iodoarenes. Chemistry. 2013;19:15759-68 pubmed publisher
    A selective N-arylation of cyclic amides and amines in DMF and water, respectively, catalysed by Cu(II) /Al2 O3 has been achieved...
  25. Lee K, Park K, Joo C, Kwon H, Jeon J, Jung H, et al. Infrared probing of 4-azidoproline conformations modulated by azido configurations. J Phys Chem B. 2012;116:5097-110 pubmed publisher
    ..These findings suggest that 4-azidoproline can be both a structure-control and -probing element, which enables the infrared tracking of proline roles in protein structure, function, and dynamics...
  26. Song H, Peng J, Yao D, Liu D, Yang Z, Du Y, et al. Metabolic disorders of fatty acids and fatty acid amides associated with human gastric cancer morbidity. Chin Med J (Engl). 2012;125:757-63 pubmed
    ..A change in the metabolism of lipids in tumor cells could lead to the pathogenesis of cancer. In this study, we investigated fatty acid and fatty acid amide metabolic perturbations associated with GC morbidity...
  27. Parving H, Brenner B, McMurray J, de Zeeuw D, Haffner S, Solomon S, et al. Baseline characteristics in the Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE). J Renin Angiotensin Aldosterone Syst. 2012;13:387-93 pubmed publisher
    ..Aliskiren, a novel direct renin inhibitor, which lowers plasma renin activity, may thereby provide greater cardio-renal protection compared with angiotensin converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) alone...
  28. Pettersson M, Johnson D, Subramanyam C, Bales K, am Ende C, Fish B, et al. Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active ?-secretase modulators. Bioorg Med Chem Lett. 2012;22:2906-11 pubmed publisher
    We report the discovery and optimization of a novel series of dihydrobenzofuran amides as ?-secretase modulators (GSMs)...
  29. Surma M, Wei L, Shi J. Rho kinase as a therapeutic target in cardiovascular disease. Future Cardiol. 2011;7:657-71 pubmed publisher
    ..This article, based on recent molecular, cellular and animal studies, focuses on the current understanding of ROCK signaling in cardiovascular diseases and in the pathogenesis of heart failure...
  30. Kong W, Casimiro M, Merino E, Nevado C. Copper-catalyzed one-pot trifluoromethylation/aryl migration/desulfonylation and C(sp2)-N bond formation of conjugated tosyl amides. J Am Chem Soc. 2013;135:14480-3 pubmed publisher
    ..one-pot trifluoromethylation/aryl migration/desulfonylation and C(sp(2))-N bond formation with conjugated tosyl amides as starting materials is presented here...
  31. Gong W, Desaulniers J. Gene-silencing properties of siRNAs that contain internal amide-bond linkages. Bioorg Med Chem Lett. 2012;22:6934-7 pubmed publisher
    ..Biophysical data indicates that melting temperatures of the siRNAs decrease when the modification is located internally...
  32. Wu H, Radomkit S, O Brien J, Hoveyda A. Metal-free catalytic enantioselective C-B bond formation: (pinacolato)boron conjugate additions to ?,?-unsaturated ketones, esters, Weinreb amides, and aldehydes promoted by chiral N-heterocyclic carbenes. J Am Chem Soc. 2012;134:8277-85 pubmed publisher
    ..Acyclic and cyclic ?,?-unsaturated ketones, as well as acyclic esters, Weinreb amides, and aldehydes, can serve as suitable substrates; the desired ?-boryl carbonyls are isolated in up to 94% yield ..
  33. Bechara W, Pelletier G, Charette A. Chemoselective synthesis of ketones and ketimines by addition of organometallic reagents to secondary amides. Nat Chem. 2012;4:228-34 pubmed publisher
    ..this context, we report a general and chemoselective method based on an activation/addition sequence on secondary amides allowing the controlled isolation of structurally diverse ketones and ketimines...
  34. Furlan A, Colombo F, Kover A, Issaly N, Tintori C, Angeli L, et al. Identification of new aminoacid amides containing the imidazo[2,1-b]benzothiazol-2-ylphenyl moiety as inhibitors of tumorigenesis by oncogenic Met signaling. Eur J Med Chem. 2012;47:239-54 pubmed publisher
  35. Das S, Addis D, Junge K, Beller M. Zinc-catalyzed chemoselective reduction of tertiary and secondary amides to amines. Chemistry. 2011;17:12186-92 pubmed publisher
    General and convenient procedures for the catalytic hydrosilylation of secondary and tertiary amides under mild conditions have been developed...
  36. Xia Q, Liu X, Zhang Y, Chen C, Chen W. Copper-catalyzed N-methylation of amides and O-methylation of carboxylic acids by using peroxides as the methylating reagents. Org Lett. 2013;15:3326-9 pubmed publisher
    The copper-catalyzed N-methylation of amides and O-methylation of carboxylic acids by using peroxides as the methylating reagent are described. Various amides and carboxylic acids were methylated affording N-substituted amides and esters...
  37. Kanyiva K, Kuninobu Y, Kanai M. Palladium-catalyzed direct C-H silylation and germanylation of benzamides and carboxamides. Org Lett. 2014;16:1968-71 pubmed publisher
    ..The bidentate directing group is readily removed and recovered by the reaction with a hydrazine, with concominant generation of an acyl hydrazide. ..
  38. Zhao C, Sun Q, Hart Cooper W, DiPasquale A, Toste F, Bergman R, et al. Chiral amide directed assembly of a diastereo- and enantiopure supramolecular host and its application to enantioselective catalysis of neutral substrates. J Am Chem Soc. 2013;135:18802-5 pubmed publisher
    ..This new assembly also exhibits high stability toward oxidation or a low pH environment and is a more robust and efficient catalyst for asymmetric organic transformations of neutral substrates. ..
  39. Lim C, Choi J, Lee B, Oh K, Yi K. Synthesis and structure-activity relationship of naphtho[1,2-b]furan-2-carboxamide derivatives as melanin concentrating hormone receptor 1 antagonists. Chem Pharm Bull (Tokyo). 2013;61:1239-47 pubmed
    ..This substance also displays good metabolic stability and it does not significantly inhibit cytochrome P450 (CYP450) enzymes. However, 10b has unacceptable oral bioavailability...
  40. Zhang J, Xiao H, Shen J, Wang N, Zhang Y. Different roles of ?-arrestin and the PKA pathway in mitochondrial ROS production induced by acute ?-adrenergic receptor stimulation in neonatal mouse cardiomyocytes. Biochem Biophys Res Commun. 2017;489:393-398 pubmed publisher
    ..Upon acute ?-AR stimulation in NMCMs, the classical cAMP/PKA pathway is responsible for faster mitochondrial ROS production, whereas ?-arrestin1 signaling is responsible for slower mitochondrial ROS production. ..
  41. Xu X, Zhao L, Zhu J, Wang M. Catalytic Asymmetric Tandem Reaction of Tertiary Enamides: Expeditious Synthesis of Pyrrolo[2,1-a]isoquinoline Alkaloid Derivatives. Angew Chem Int Ed Engl. 2016;55:3799-803 pubmed publisher
    ..The cyclization products, which are difficult to obtain by other synthetic means, are structural motifs found in many bioactive alkaloids. ..
  42. Moraes F, Alvarenga E, Amorim K, Demuner A, Pereira Flores M. Novel platensimycin derivatives with herbicidal activity. Pest Manag Sci. 2016;72:580-4 pubmed publisher
    ..Lumisantonin and five novel amides have been evaluated against two monocotyledons and three dicotyledons...
  43. Yamaguchi R, Yamamoto T, Sakamoto A, Ishimaru Y, Narahara S, Sugiuchi H, et al. Substance P enhances tissue factor release from granulocyte-macrophage colony-stimulating factor-dependent macrophages via the p22phox/β-arrestin 2/Rho A signaling pathway. Blood Cells Mol Dis. 2016;57:85-90 pubmed publisher
    ..In other experiments, visceral adipocytes derived from cryopreserved preadipocytes were found to produce SP. In conclusion, SP enhances the release of TF from macrophages via the p22phox/β-arrestin 2/Rho A signaling pathway. ..
  44. Wiesmann T, Piechowiak K, Duderstadt S, Haupt D, Schmitt J, Eschbach D, et al. Continuous adductor canal block versus continuous femoral nerve block after total knee arthroplasty for mobilisation capability and pain treatment: a randomised and blinded clinical trial. Arch Orthop Trauma Surg. 2016;136:397-406 pubmed publisher
    ..Moreover, no difference was observed concerning analgesia quality. ..
  45. Cai Y, Sarotti A, Gündisch D, Kondratyuk T, Pezzuto J, Turkson J, et al. Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities. Bioorg Med Chem Lett. 2017;27:4630-4634 pubmed publisher
    ..The absolute configuration (AC) of compound 1 was determined by comparison of its optical rotation with those reported in literature. Compound 2 showed inhibition against NF-?B with an IC50 value of 36?M. ..
  46. Tian X, Zhang S, Zheng L. First Novozym 435 lipase-catalyzed Morita-Baylis-Hillman reaction in the presence of amides. Enzyme Microb Technol. 2016;84:32-40 pubmed publisher
    The first Novozym 435 lipase-catalyzed Morita-Baylis-Hillman (MBH) reaction with amides as co-catalyst was realized. Results showed that neither Novozym 435 nor amide can independently catalyze the reaction...
  47. Aman W, Lee J, Kim M, Yang S, Jung H, Hah J. Discovery of highly selective CRAF inhibitors, 3-carboxamido-2H-indazole-6-arylamide: In silico FBLD design, synthesis and evaluation. Bioorg Med Chem Lett. 2016;26:1188-92 pubmed publisher
    ..6 nM, which shows greater than 270-fold selectivity over BRAF kinase (9.45 μM). ..
  48. Hwang E, Lee T, Lee W, Shim W, Yeo E, Kim S, et al. A novel synthetic Piper amide derivative NED-180 inhibits hyperpigmentation by activating the PI3K and ERK pathways and by regulating Ca2+ influx via TRPM1 channels. Pigment Cell Melanoma Res. 2016;29:81-91 pubmed publisher
    Piper amides have a characteristic, unsaturated amide group and exhibit diverse biological activities, including proliferation and differentiation of melanocytes, although the molecular mechanisms underlying its antimelanogenesis effect ..
  49. da Silva C, Fraceto L, Franz Montan M, Couto V, Casadei B, Cereda C, et al. Development of egg PC/cholesterol/?-tocopherol liposomes with ionic gradients to deliver ropivacaine. J Liposome Res. 2016;26:1-10 pubmed publisher
    ..Studies with RVC encapsulated in liposomes and complexed in cyclodextrins have shown good results, but in order to use RVC for lengthy procedures and during the postoperative period, a still more prolonged anesthetic effect is required...
  50. Dickens A, Vainio S, Marjamaki P, Johansson J, Lehtiniemi P, Rokka J, et al. Detection of microglial activation in an acute model of neuroinflammation using PET and radiotracers 11C-(R)-PK11195 and 18F-GE-180. J Nucl Med. 2014;55:466-72 pubmed publisher
    ..Using immunohistochemistry, we also explore the ability of the TSPO ligands to detect activated microglial cells and astrocytes...
  51. Zhou C, Avins J, Klauser P, Brandsen B, Lee Y, Silverman S. DNA-Catalyzed Amide Hydrolysis. J Am Chem Soc. 2016;138:2106-9 pubmed publisher
    ..The results also suggest the longer-term feasibility of deoxyribozymes as artificial proteases. ..
  52. Gibson C, Srivastava K, Sprigg N, Bath P, Bayraktutan U. Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions. J Neurochem. 2014;129:816-26 pubmed publisher
  53. Leven M, Knaab T, Held J, Duffy S, Meister S, Fischli C, et al. 3-Hydroxy-N'-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally. J Med Chem. 2017;60:6036-6044 pubmed publisher
    ..Particularly, derivatives with a 1,3-dihalo-6-trifluoromethylphenanthrene moiety showed outstanding in vivo properties and demonstrated in part curative activity in the Plasmodium berghei mouse model when administered perorally...