acrolein

Summary

Summary: Unsaturated three-carbon aldehyde.

Top Publications

  1. Leung G, Sun W, Zheng L, Brookes S, Tully M, Shi R. Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune encephalomyelitis mouse. Neuroscience. 2011;173:150-5 pubmed publisher
    Oxidative stress is considered a major contributor in the pathology of multiple sclerosis (MS). Acrolein, a highly reactive aldehyde byproduct of lipid peroxidation, is thought to perpetuate oxidative stress...
  2. Kim G, Lee S, Kim T, Jin Y, Park Y, Park C. Melatonin suppresses acrolein-induced IL-8 production in human pulmonary fibroblasts. J Pineal Res. 2012;52:356-64 pubmed publisher
    ..Furthermore, recent studies show that, ?, ?-unsaturated aldehyde acrolein in CS induces the production of interleukin (IL)-8, which is known to be related to bronchitis, rhinitis, ..
  3. Kozekov I, Turesky R, Alas G, Harris C, Harris T, Rizzo C. Formation of deoxyguanosine cross-links from calf thymus DNA treated with acrolein and 4-hydroxy-2-nonenal. Chem Res Toxicol. 2010;23:1701-13 pubmed publisher
    b>Acrolein (AC) and 4-hydroxy-2-nonenal (HNE) are endogenous bis-electrophiles that arise from the oxidation of polyunsaturated fatty acids. AC is also found in high concentrations in cigarette smoke and automobile exhaust...
  4. Alexander N, Blount A, Zhang S, Skinner D, Hicks S, Chestnut M, et al. Cystic fibrosis transmembrane conductance regulator modulation by the tobacco smoke toxin acrolein. Laryngoscope. 2012;122:1193-7 pubmed publisher
    ..The objective of the current study was to evaluate the effects of acrolein exposure (a prominent tobacco smoke toxin) on vectorial Cl(-) transport through the major apical anion channel ..
  5. Baba S, Hoetker J, Merchant M, Klein J, Cai J, Barski O, et al. Role of aldose reductase in the metabolism and detoxification of carnosine-acrolein conjugates. J Biol Chem. 2013;288:28163-79 pubmed publisher
    ..Here we report that conjugates of carnosine with aldehydes such as acrolein are produced during normal metabolism and excreted in the urine of mice and adult human non-smokers as carnosine-..
  6. Chen D, Fang L, Li H, Tang M, Jin C. Cigarette smoke component acrolein modulates chromatin assembly by inhibiting histone acetylation. J Biol Chem. 2013;288:21678-87 pubmed publisher
    ..b>Acrolein (Acr) is an ?,?-unsaturated aldehyde, which is abundant in the environment, especially in cigarette smoke...
  7. Brackman G, Celen S, Hillaert U, Van Calenbergh S, Cos P, Maes L, et al. Structure-activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum sensing and their effect on virulence of Vibrio spp. PLoS ONE. 2011;6:e16084 pubmed publisher
    ..However, little is known about the structure-activity relationship of cinnamaldehyde analogs...
  8. Myers C, Myers J, Kufahl T, Forbes R, Szadkowski A. The effects of acrolein on the thioredoxin system: implications for redox-sensitive signaling. Mol Nutr Food Res. 2011;55:1361-74 pubmed publisher
    The reactive aldehyde acrolein is a ubiquitous environmental pollutant and is also generated endogenously. It is a strong electrophile and reacts rapidly with nucleophiles including thiolates...
  9. Ismahil M, Hamid T, Haberzettl P, Gu Y, Chandrasekar B, Srivastava S, et al. Chronic oral exposure to the aldehyde pollutant acrolein induces dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2011;301:H2050-60 pubmed publisher
    Environmental triggers of dilated cardiomyopathy are poorly understood. Acute exposure to acrolein, a ubiquitous aldehyde pollutant, impairs cardiac function and cardioprotective responses in mice...

More Information

Publications62

  1. Singh M, Dang T, Arseneault M, Ramassamy C. Role of by-products of lipid oxidation in Alzheimer's disease brain: a focus on acrolein. J Alzheimers Dis. 2010;21:741-56 pubmed publisher
    ..formation of a number of aldehydes by-products, including malondialdehyde (MDA), 4-hydroxy-2-nonenal (HNE), and acrolein. The most abundant aldehydes are HNE and MDA while acrolein is the most reactive...
  2. Zhang X, Li W, Li W, Ren K, Fan C, Chen Y, et al. Protective effects of the aqueous extract of Scutellaria baicalensis against acrolein-induced oxidative stress in cultured human umbilical vein endothelial cells. Pharm Biol. 2011;49:256-61 pubmed publisher
    ..Scutellaria baicalensis Georgi (Labiatae) (SbG), one of the fifty fundamental herbs of Chinese herbology, has been reported to have anti-asthmatic, antifungal, antioxidative, and anti-inflammatory activities...
  3. Wondrak G, Villeneuve N, Lamore S, Bause A, Jiang T, Zhang D. The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells. Molecules. 2010;15:3338-55 pubmed publisher
    ..CA may therefore represent an underappreciated chemopreventive dietary factor targeting colorectal carcinogenesis...
  4. Aldini G, Orioli M, Carini M. Protein modification by acrolein: relevance to pathological conditions and inhibition by aldehyde sequestering agents. Mol Nutr Food Res. 2011;55:1301-19 pubmed publisher
    b>Acrolein (ACR) is a toxic and highly reactive ?,?-unsaturated aldehyde widely distributed in the environment as a common pollutant and generated endogenously mainly by lipoxidation reactions...
  5. Hsu F, Li W, Yu C, Hsieh Y, Yang Y, Liu J, et al. In vivo antioxidant activities of essential oils and their constituents from leaves of the Taiwanese Cinnamomum osmophloeum. J Agric Food Chem. 2012;60:3092-7 pubmed publisher
    ..osmophloeum leaves. Our results showed that the essential oils from C. osmophloeum leaves and their major compounds might have good potential for further development as nutraceuticals or antioxidant remedies...
  6. Zhu Q, Sun Z, Jiang Y, Chen F, Wang M. Acrolein scavengers: reactivity, mechanism and impact on health. Mol Nutr Food Res. 2011;55:1375-90 pubmed publisher
    b>Acrolein (ACR) is an ?,?-unsaturated aldehyde that exists extensively in the environment and (thermally processed) foods. It can also be generated through endogenous metabolism...
  7. Moretto N, Volpi G, Pastore F, Facchinetti F. Acrolein effects in pulmonary cells: relevance to chronic obstructive pulmonary disease. Ann N Y Acad Sci. 2012;1259:39-46 pubmed publisher
    b>Acrolein (2-propenal) is a highly reactive ?,?-unsaturated aldehyde and a respiratory irritant that is ubiquitously present in the environment but that can also be generated endogenously at sites of inflammation...
  8. Grigsby J, Betts B, Vidro Kotchan E, Culbert R, Tsin A. A possible role of acrolein in diabetic retinopathy: involvement of a VEGF/TGF? signaling pathway of the retinal pigment epithelium in hyperglycemia. Curr Eye Res. 2012;37:1045-53 pubmed publisher
    b>Acrolein has been implicated in retinal pigment epithelium (RPE) cell death, and has been associated with diabetic retinopathy...
  9. Bai L, Wang W, Dong Y, Wang W, Huang J, Wang X, et al. Attenuation of mouse somatic and emotional inflammatory pain by hydralazine through scavenging acrolein and inhibiting neuronal activation. Pain Physician. 2012;15:311-26 pubmed
    b>Acrolein signaling is important during spinal cord injury; whether it is involved in somatic and emotional pain is not clear. Hydralazine is a potent antihypertensive drug and can scavenge acrolein efficiently.
  10. Minagawa T, Aizawa N, Igawa Y, Wyndaele J. Inhibitory effects of phosphodiesterase 5 inhibitor, tadalafil, on mechanosensitive bladder afferent nerve activities of the rat, and on acrolein-induced hyperactivity of these nerves. BJU Int. 2012;110:E259-66 pubmed publisher
    ..One of the mechanisms of tadalafil on LUTS is added in the study...
  11. Córdova M, Werner M, Silva M, Ruani A, Pizzolatti M, Santos A. Further antinociceptive effects of myricitrin in chemical models of overt nociception in mice. Neurosci Lett. 2011;495:173-7 pubmed publisher
    ..e. cinnamaldehyde, acidified saline and menthol), probably via inhibition of PKC pathways. Thus, myricitrin could constitute an attractive molecule of interest for the development of new analgesic drugs...
  12. Yang E, Woo S, Choi K, Kwon T. Acrolein sensitizes human renal cancer Caki cells to TRAIL-induced apoptosis via ROS-mediated up-regulation of death receptor-5 (DR5) and down-regulation of Bcl-2. Exp Cell Res. 2011;317:2592-601 pubmed publisher
    ..b>Acrolein is a byproduct of lipid peroxidation, which has been involved in pulmonary, cardiac and neurodegenerative ..
  13. Shi Y, Sun W, McBride J, Cheng J, Shi R. Acrolein induces myelin damage in mammalian spinal cord. J Neurochem. 2011;117:554-64 pubmed publisher
    ..Here, we show that acrolein, a lipid peroxidation product, can cause significant myelin damage in isolated guinea pig spinal cord segments...
  14. Choudhury S, Dyba M, Pan J, Roy R, Chung F. Repair kinetics of acrolein- and (E)-4-hydroxy-2-nonenal-derived DNA adducts in human colon cell extracts. Mutat Res. 2013;751-752:15-23 pubmed publisher
    ..Upon oxidation, PUFAs generate ?,?-unsaturated aldehydes or enals, such as acrolein (Acr) and (E)-4-hydroxy-2-nonenal (HNE), which can form cyclic adducts of deoxyguanosine (Acr-dG and HNE-dG, ..
  15. Saito R, Shimakawa G, Nishi A, Iwamoto T, Sakamoto K, Yamamoto H, et al. Functional analysis of the AKR4C subfamily of Arabidopsis thaliana: model structures, substrate specificity, acrolein toxicity, and responses to light and [CO(2)]. Biosci Biotechnol Biochem. 2013;77:2038-45 pubmed
    ..b>Acrolein, a lipid-derived RC, inactivated the four enzymes to different degrees...
  16. Wang C, Weng T, Wu E, Wu M, Yang R, Liu S. Involvement of interleukin-6-regulated nitric oxide synthase in hemorrhagic cystitis and impaired bladder contractions in young rats induced by acrolein, a urinary metabolite of cyclophosphamide. Toxicol Sci. 2013;131:302-10 pubmed publisher
    ..b>Acrolein is a urinary metabolite from cyclophosphamide and can induce hemorrhagic cystitis...
  17. Wang L, Sun Y, Asahi M, Otsu K. Acrolein, an environmental toxin, induces cardiomyocyte apoptosis via elevated intracellular calcium and free radicals. Cell Biochem Biophys. 2011;61:131-6 pubmed publisher
    b>Acrolein, an unsaturated aldehyde, is an environmental toxin known to inhibit mitochondrial electron transport chain in brain and induce lipid peroxidation and apoptosis...
  18. Saiki R, Park H, Ishii I, Yoshida M, Nishimura K, Toida T, et al. Brain infarction correlates more closely with acrolein than with reactive oxygen species. Biochem Biophys Res Commun. 2011;404:1044-9 pubmed publisher
    ..the major factor responsible for cell damage is reactive oxygen species (ROS), our recent studies have shown that acrolein is more toxic than ROS...
  19. Wheat L, Haberzettl P, Hellmann J, Baba S, Bertke M, Lee J, et al. Acrolein inhalation prevents vascular endothelial growth factor-induced mobilization of Flk-1+/Sca-1+ cells in mice. Arterioscler Thromb Vasc Biol. 2011;31:1598-606 pubmed publisher
    b>Acrolein is a toxic chemical present in tobacco, wood, and coal smoke, as well as automobile exhaust...
  20. Kasiviswanathan R, Minko I, Lloyd R, Copeland W. Translesion synthesis past acrolein-derived DNA adducts by human mitochondrial DNA polymerase ?. J Biol Chem. 2013;288:14247-55 pubmed publisher
    b>Acrolein, a mutagenic aldehyde, is produced endogenously by lipid peroxidation and exogenously by combustion of organic materials, including tobacco products...
  21. Moretto N, Bertolini S, Iadicicco C, Marchini G, Kaur M, Volpi G, et al. Cigarette smoke and its component acrolein augment IL-8/CXCL8 mRNA stability via p38 MAPK/MK2 signaling in human pulmonary cells. Am J Physiol Lung Cell Mol Physiol. 2012;303:L929-38 pubmed publisher
    ..CSE-evoked elevation of IL-8 mRNA was mimicked by its component acrolein. Both CSE and acrolein induced p38 mitogen-activated protein kinase (MAPK) phosphorylation, accompanied by the ..
  22. Ren S, Guo L, Yang J, Liu D, Wang T, Chen L, et al. Doxycycline attenuates acrolein-induced mucin production, in part by inhibiting MMP-9. Eur J Pharmacol. 2011;650:418-23 pubmed publisher
    ..have been found to increase the expression of epidermal growth factor (EGF) receptor, a possible regulator of acrolein-induced mucin expression in the airway epithelium...
  23. Shi R, Rickett T, Sun W. Acrolein-mediated injury in nervous system trauma and diseases. Mol Nutr Food Res. 2011;55:1320-31 pubmed publisher
    b>Acrolein, an ?,?-unsaturated aldehyde, is a ubiquitous pollutant that is also produced endogenously through lipid peroxidation...
  24. Volpi G, Facchinetti F, Moretto N, Civelli M, Patacchini R. Cigarette smoke and ?,?-unsaturated aldehydes elicit VEGF release through the p38 MAPK pathway in human airway smooth muscle cells and lung fibroblasts. Br J Pharmacol. 2011;163:649-61 pubmed publisher
    ..The aim of this study was to investigate whether acute exposure to cigarette smoke extract altered VEGF production in lung parenchymal cells...
  25. Srivastava S, Sithu S, Vladykovskaya E, Haberzettl P, Hoetker D, Siddiqui M, et al. Oral exposure to acrolein exacerbates atherosclerosis in apoE-null mice. Atherosclerosis. 2011;215:301-8 pubmed publisher
    b>Acrolein is a dietary aldehyde that is present in high concentrations in alcoholic beverages and foods including cheese, donuts and coffee...
  26. Nakamura M, Tomitori H, Suzuki T, Sakamoto A, Terui Y, Saiki R, et al. Inactivation of GAPDH as one mechanism of acrolein toxicity. Biochem Biophys Res Commun. 2013;430:1265-71 pubmed publisher
    We have recently reported that acrolein is more toxic than reactive oxygen species. Thus, the mechanism of cell toxicity by acrolein was studied using mouse mammary carcinoma FM3A cells...
  27. Choi J, Hwang Y, Han E, Kim H, Park B, Lee H, et al. Inhibition of acrolein-stimulated MUC5AC expression by Platycodon grandiflorum root-derived saponin in A549 cells. Food Chem Toxicol. 2011;49:2157-66 pubmed publisher
    ..In this study, we investigated the inhibition of acrolein-induced expression of mucin 5, subtypes A and C (MUC5AC) by Changkil saponin (CKS) in A549 cells...
  28. Dang T, Arseneault M, Zarkovic N, Waeg G, Ramassamy C. Molecular regulations induced by acrolein in neuroblastoma SK-N-SH cells: relevance to Alzheimer's disease. J Alzheimers Dis. 2010;21:1197-216 pubmed
    b>Acrolein is the most reactive aldehyde among the by-products of lipid peroxidation. Growing evidence indicates that acrolein may play an important role in the pathogenesis of Alzheimer's disease (AD)...
  29. Spiess P, Deng B, Hondal R, Matthews D, van Der Vliet A. Proteomic profiling of acrolein adducts in human lung epithelial cells. J Proteomics. 2011;74:2380-94 pubmed publisher
    b>Acrolein (2,3-propenal) is a major indoor and outdoor air pollutant originating largely from tobacco smoke or organic combustion...
  30. Huang Y, Jin M, Pi R, Zhang J, Ouyang Y, Chao X, et al. Acrolein induces Alzheimer's disease-like pathologies in vitro and in vivo. Toxicol Lett. 2013;217:184-91 pubmed publisher
    The pathologic mechanisms of Alzheimer's disease (AD) have not been fully uncovered. Acrolein, a ubiquitous dietary pollutant and by-product of oxidative stress, can induce cytotoxicity in neurons, which might play an important role in ..
  31. Mohammad M, Avila D, Zhang J, Barve S, Arteel G, McClain C, et al. Acrolein cytotoxicity in hepatocytes involves endoplasmic reticulum stress, mitochondrial dysfunction and oxidative stress. Toxicol Appl Pharmacol. 2012;265:73-82 pubmed publisher
    b>Acrolein is a common environmental, food and water pollutant and a major component of cigarette smoke. Also, it is produced endogenously via lipid peroxidation and cellular metabolism of certain amino acids and drugs...
  32. Wang H, Weng M, Chen W, Yobin M, Pan J, Chung F, et al. Effect of CpG methylation at different sequence context on acrolein- and BPDE-DNA binding and mutagenesis. Carcinogenesis. 2013;34:220-7 pubmed publisher
    b>Acrolein (Acr), an ?,?-unsaturated aldehyde, is abundant in tobacco smoke and cooking and exhaust fumes. Acr induces mutagenic ?- and ?- hydroxy-1,N(2)-cyclic propano-deoxyguanosine adducts in normal human bronchial epithelial cells...
  33. Wang H, Hu Y, Tong D, Huang J, Gu L, Wu X, et al. Effect of carcinogenic acrolein on DNA repair and mutagenic susceptibility. J Biol Chem. 2012;287:12379-86 pubmed publisher
    b>Acrolein (Acr), a ubiquitous environmental contaminant, is a human carcinogen. Acr can react with DNA to form mutagenic ?- and ?-hydroxy-1, N(2)-cyclic propano-2'-deoxyguanosine adducts (?-OH-Acr-dG and ?-OH-Acr-dG)...
  34. Shiramizu M, Toste F. On the Diels-Alder approach to solely biomass-derived polyethylene terephthalate (PET): conversion of 2,5-dimethylfuran and acrolein into p-xylene. Chemistry. 2011;17:12452-7 pubmed publisher
    ..Specifically, 2,5-dimethylfuran (derived from lignocellulosic biomass through 5-(hydroxymethyl)furfural) and acrolein (produced from glycerol, a side product of biodiesel production) were converted into the key intermediate p-..
  35. Ahmed M, Langer H, Abed M, Voelkl J, Lang F. The uremic toxin acrolein promotes suicidal erythrocyte death. Kidney Blood Press Res. 2013;37:158-67 pubmed publisher
    ..Erythrocytes could be sensitized to cytosolic Ca(2+) by ceramide. In end stage renal disease, eryptosis may possibly be stimulated by uremic toxins. The present study explored, whether the uremic toxin acrolein could trigger eryptosis.
  36. Zhang S, Balbo S, Wang M, Hecht S. Analysis of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human leukocyte DNA from smokers and nonsmokers. Chem Res Toxicol. 2011;24:119-24 pubmed publisher
    Cigarette smoking is a major source of human exposure to acrolein, a widespread environmental pollutant and toxicant that is also formed endogenously through metabolism of amino acids and polyamines and lipid peroxidation...
  37. Aizawa N, Igawa Y, Nishizawa O, Wyndaele J. Effects of nitric oxide on the primary bladder afferent activities of the rat with and without intravesical acrolein treatment. Eur Urol. 2011;59:264-71 pubmed publisher
    It has been suggested that nitric oxide (NO) affects the afferent pathways innervating the bladder. In addition, acrolein, a metabolite of cyclophosphamide, causes bladder hypersensitivity in rats.
  38. Ouyang X, Tran Q, Goodwin S, Wible R, Sutter C, Sutter T. Yap1 activation by H2O2 or thiol-reactive chemicals elicits distinct adaptive gene responses. Free Radic Biol Med. 2011;50:1-13 pubmed publisher
    ..N-ethylmaleimide (NEM) showed no cross-protection against each other, whereas another thiol-reactive chemical, acrolein, elicited Yap1-dependent cross-protection against NEM, but not H(2)O(2)...
  39. Liu Z, Sun L, Zhu L, Jia X, Li X, Jia H, et al. Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction. J Neurochem. 2007;103:2690-700 pubmed publisher
    ..In the present study, we investigated the protective effects of HTS on acrolein-induced toxicity in human retinal pigment epithelial cell line, ARPE-19, a cellular model of smoking- and age-..
  40. Tully M, Shi R. New insights in the pathogenesis of multiple sclerosis--role of acrolein in neuronal and myelin damage. Int J Mol Sci. 2013;14:20037-47 pubmed publisher
    ..b>Acrolein, a toxic ?-unsaturated aldehyde capable of initiating and perpetuating oxidative stress, has been suggested as a ..
  41. Cheah E, Burcham P, Mann T, Henry P. Acrolein relaxes mouse isolated tracheal smooth muscle via a TRPA1-dependent mechanism. Biochem Pharmacol. 2014;89:148-56 pubmed publisher
    ..sensory C-fibres express TRPA1 channels which have recently been identified as a key chemosensory receptor for acrolein, a toxic and highly prevalent component of smoke...
  42. Huang J, Zhao L, Liu Y, Cao W, Wu X. Enantioselective intermolecular formal [3 + 3] cycloaddition of 2,3-disubstituted indoles with acrolein. Org Lett. 2013;15:4338-41 pubmed publisher
    ..highly substituted hydrocarbazoles has been realized by an organocatalyzed formal [3 + 3] cycloaddition between acrolein and 2,3-disubstituted indoles...
  43. Klafke J, da Silva M, Trevisan G, Rossato M, da Silva C, Guerra G, et al. Involvement of the glutamatergic system in the nociception induced intrathecally for a TRPA1 agonist in rats. Neuroscience. 2012;222:136-46 pubmed publisher
    ..Then the modulation of spinal TRPA1 might be a valuable target in painful conditions associated with central pain hypersensitivity...
  44. Kitaguchi Y, Taraseviciene Stewart L, Hanaoka M, Natarajan R, Kraskauskas D, Voelkel N. Acrolein induces endoplasmic reticulum stress and causes airspace enlargement. PLoS ONE. 2012;7:e38038 pubmed publisher
    Given the relative abundance and toxic potential of acrolein in inhaled cigarette smoke, it is surprising how little is known about the pulmonary and systemic effects of acrolein...
  45. Bein K, Leikauf G. Acrolein - a pulmonary hazard. Mol Nutr Food Res. 2011;55:1342-60 pubmed publisher
    b>Acrolein is a respiratory irritant that can be generated during cooking and is in environmental tobacco smoke...
  46. Abraham K, Andres S, Palavinskas R, Berg K, Appel K, Lampen A. Toxicology and risk assessment of acrolein in food. Mol Nutr Food Res. 2011;55:1277-90 pubmed publisher
    b>Acrolein is an ?,?-unsaturated aldehyde formed by thermal treatment of animal and vegetable fats, carbohydrates and amino acids. In addition it is generated endogenously...
  47. Hristova M, Spiess P, Kasahara D, Randall M, Deng B, van Der Vliet A. The tobacco smoke component, acrolein, suppresses innate macrophage responses by direct alkylation of c-Jun N-terminal kinase. Am J Respir Cell Mol Biol. 2012;46:23-33 pubmed publisher
    ..innate immune system is often compromised by tobacco smoke exposure, and previous studies have indicated that acrolein, a reactive electrophile in tobacco smoke, may contribute to the immunosuppressive effects of smoking...
  48. Tang M, Wang H, Hu Y, Chen W, Akao M, Feng Z, et al. Acrolein induced DNA damage, mutagenicity and effect on DNA repair. Mol Nutr Food Res. 2011;55:1291-300 pubmed publisher
    b>Acrolein (Acr) is a ubiquitous environmental contaminant; it also can be generated endogenously by lipid peroxidation...
  49. Plaisier C, Cok A, Scott J, Opejin A, Bushhouse K, Salie M, et al. Effects of cinnamaldehyde on the glucose transport activity of GLUT1. Biochimie. 2011;93:339-44 pubmed publisher
    ..This dual activity of cinnamaldehyde on the transport activity of GLUT1 suggests that cinnamaldehyde is not a major contributor to the anti-diabetic properties of cinnamon...
  50. Li L, Jiang L, Geng C, Cao J, Zhong L. The role of oxidative stress in acrolein-induced DNA damage in HepG2 cells. Free Radic Res. 2008;42:354-61 pubmed publisher
    This study evaluated the role of oxidative stress in acrolein-induced DNA damage, using HepG2 cells...
  51. Beretta G, Arlandini E, Artali R, Anton J, Maffei Facino R. Acrolein sequestering ability of the endogenous tripeptide glycyl-histidyl-lysine (GHK): characterization of conjugation products by ESI-MSn and theoretical calculations. J Pharm Biomed Anal. 2008;47:596-602 pubmed publisher
    b>Acrolein (ACR) is a well-known carbonyl toxin produced by lipid peroxidation of polyunsaturated fatty acids, which is involved in several life-threatening pathologies such as Alzheimer disease, arteriosclerosis, diabetes, and nephropathy...
  52. Hazari M, Rowan W, Winsett D, Ledbetter A, Haykal Coates N, Watkinson W, et al. Potentiation of pulmonary reflex response to capsaicin 24h following whole-body acrolein exposure is mediated by TRPV1. Respir Physiol Neurobiol. 2008;160:160-71 pubmed
    ..While acrolein has been shown to stimulate C-fibers, the persistence of acrolein effects and the role of C-fibers in these ..
  53. Moon E, Lee M, Wang A, Lee J, Kim H, Kim H, et al. Delayed occurrence of H-ras12V-induced hepatocellular carcinoma with long-term treatment with cinnamaldehydes. Eur J Pharmacol. 2006;530:270-5 pubmed
    ..Data suggest that the delayed hepatic tumor development observed with BCA could be mediated by a long-term immunostimulating effect on T cells...